index,Instruction,molecule,added_group
101639,Please add a amide to the molecule CC(C)(CNC(=O)N[C@H]1CCN(CC(F)(F)F)C1)NS(C)(=O)=O.,CC(C)(CNC(=O)N[C@H]1CCN(CC(F)(F)F)C1)NS(C)(=O)=O,amide
224282,Please add a amide to the molecule O=C(COc1cccc(I)c1)N(c1ccccc1)[C@@H]1CCS(=O)(=O)C1.,O=C(COc1cccc(I)c1)N(c1ccccc1)[C@@H]1CCS(=O)(=O)C1,amide
222794,Add a benzene ring to the molecule Cc1ccc2nc(N3C(=O)C([O-])=C(C(=O)c4ccncc4)[C@H]3c3ccccc3)sc2c1.,Cc1ccc2nc(N3C(=O)C([O-])=C(C(=O)c4ccncc4)[C@H]3c3ccccc3)sc2c1,benzene ring
45537,Add a benzene ring to the molecule Cc1cnc(S(=O)(=O)Cc2noc3c2CCCC3)nc1.,Cc1cnc(S(=O)(=O)Cc2noc3c2CCCC3)nc1,benzene ring
6906,Please add a nitro to the molecule CC(C)(C)OC(=O)N1CCC[C@H](C(=O)N[C@H]2CCS(=O)(=O)C2)C1.,CC(C)(C)OC(=O)N1CCC[C@H](C(=O)N[C@H]2CCS(=O)(=O)C2)C1,nitro
132678,Please add a carboxyl to the molecule O=C(c1cccc(O)c1)N1CC[NH+]([C@H]2CCC[C@H](C3CC3)C2)CC1.,O=C(c1cccc(O)c1)N1CC[NH+]([C@H]2CCC[C@H](C3CC3)C2)CC1,carboxyl
35178,Please add a benzene ring to the molecule Cc1nnc2n1CCC[C@H]2NC(=O)Nc1cnn(CC[NH+]2CCCCC2)c1.,Cc1nnc2n1CCC[C@H]2NC(=O)Nc1cnn(CC[NH+]2CCCCC2)c1,benzene ring
102437,Add a hydroxyl to the molecule Cc1coc(-c2cccc(NC(=O)C(=O)N[C@H]3CC[C@H]([NH+](C)C)C3)c2)n1.,Cc1coc(-c2cccc(NC(=O)C(=O)N[C@H]3CC[C@H]([NH+](C)C)C3)c2)n1,hydroxyl
180042,Please add a benzene ring to the molecule C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)/C=C/c1cccc([N+](=O)[O-])c1.,C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)/C=C/c1cccc([N+](=O)[O-])c1,benzene ring
144193,Add a amide to the molecule CSCC[C@H]1[NH+]=C(c2ccccc2)N(C2CC2)C1=[NH2+].,CSCC[C@H]1[NH+]=C(c2ccccc2)N(C2CC2)C1=[NH2+],amide
56939,Please add a carboxyl to the molecule CC[NH2+][C@H](CC)c1ccccc1OCc1ccncc1.,CC[NH2+][C@H](CC)c1ccccc1OCc1ccncc1,carboxyl
105820,Modify the molecule CCCCCC(=O)N1CCO[C@H](C(N)=S)C1 by adding a aldehyde.,CCCCCC(=O)N1CCO[C@H](C(N)=S)C1,aldehyde
222213,Please add a amine to the molecule CCCN/C([O-])=C(\C#N)C(=O)Cn1c(=O)n(CC)c2ccccc21.,CCCN/C([O-])=C(\C#N)C(=O)Cn1c(=O)n(CC)c2ccccc21,amine
227562,Please add a amine to the molecule C[C@H](NCCc1nc2c(F)cccc2n1C)c1ccc(F)cn1.,C[C@H](NCCc1nc2c(F)cccc2n1C)c1ccc(F)cn1,amine
79183,Modify the molecule CN(C)c1ccc(NC(=O)CSc2nnc(C(F)(F)F)n2-c2ccccc2)cc1 by adding a amide.,CN(C)c1ccc(NC(=O)CSc2nnc(C(F)(F)F)n2-c2ccccc2)cc1,amide
33778,Please add a hydroxyl to the molecule Cc1n[nH]c(COc2ccccc2)c1CO.,Cc1n[nH]c(COc2ccccc2)c1CO,hydroxyl
141553,Modify the molecule CCC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@H]1S[C@@H](C)CC by adding a halo.,CCC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@H]1S[C@@H](C)CC,halo
211941,Modify the molecule Cc1ccc(CCN(Cc2cncs2)CC(F)(F)F)cc1 by adding a benzene ring.,Cc1ccc(CCN(Cc2cncs2)CC(F)(F)F)cc1,benzene ring
135463,Modify the molecule CC(=O)Nc1ccc(-c2nc3cc(Cl)c([N+](=O)[O-])cc3[nH]2)cc1 by adding a benzene ring.,CC(=O)Nc1ccc(-c2nc3cc(Cl)c([N+](=O)[O-])cc3[nH]2)cc1,benzene ring
83309,Please add a amide to the molecule CCC[NH+](CCC)CC(=O)Nc1ccc(C)c(C)c1.,CCC[NH+](CCC)CC(=O)Nc1ccc(C)c(C)c1,amide
79088,Add a amide to the molecule NC(=O)COc1ccc(CN2CCO[C@H](C(F)(F)F)C2)cc1Cl.,NC(=O)COc1ccc(CN2CCO[C@H](C(F)(F)F)C2)cc1Cl,amide
228434,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1N1CCN(C(=O)CC2CCCC2)CC1 by adding a benzene ring.,Cc1nn(-c2ccccc2)c(C)c1N1CCN(C(=O)CC2CCCC2)CC1,benzene ring
206143,Modify the molecule CCn1nc(C(C)C)cc1C(=O)N1CSC[C@H]1C(=O)[O-] by adding a benzene ring.,CCn1nc(C(C)C)cc1C(=O)N1CSC[C@H]1C(=O)[O-],benzene ring
145187,Add a nitro to the molecule CCOC(=O)C(=O)NC[C@@H]1CCCO1.,CCOC(=O)C(=O)NC[C@@H]1CCCO1,nitro
66687,Modify the molecule Cc1ccc(C)c(CS(=O)(=O)Cc2cc(=O)n3cccc(C)c3n2)c1 by adding a nitro.,Cc1ccc(C)c(CS(=O)(=O)Cc2cc(=O)n3cccc(C)c3n2)c1,nitro
41737,Add a carboxyl to the molecule O=C(c1ccnc(OC2CCC2)c1)N1CCOc2cc(F)ccc21.,O=C(c1ccnc(OC2CCC2)c1)N1CCOc2cc(F)ccc21,carboxyl
74084,Add a benzene ring to the molecule COc1ccccc1NC(=O)C1=C(C)Nc2nnnn2[C@@H]1c1cc(Cl)ccc1OC(F)F.,COc1ccccc1NC(=O)C1=C(C)Nc2nnnn2[C@@H]1c1cc(Cl)ccc1OC(F)F,benzene ring
25315,Modify the molecule Cc1cc2ncn(C(=O)[C@H]3CC(=O)N(c4ccc(C)c(Cl)c4)C3)c2cc1C by adding a hydroxyl.,Cc1cc2ncn(C(=O)[C@H]3CC(=O)N(c4ccc(C)c(Cl)c4)C3)c2cc1C,hydroxyl
242609,Please add a thiol to the molecule CCS(=O)(=O)N1CCC(NS(=O)(=O)c2c(C)c(Cl)cc(C)c2Cl)CC1.,CCS(=O)(=O)N1CCC(NS(=O)(=O)c2c(C)c(Cl)cc(C)c2Cl)CC1,thiol
241907,Modify the molecule Cc1c(C)c2ccc(OCC(=O)Nc3ccc(F)cc3F)cc2oc1=O by adding a nitro.,Cc1c(C)c2ccc(OCC(=O)Nc3ccc(F)cc3F)cc2oc1=O,nitro
152956,Add a hydroxyl to the molecule Brc1cc(-c2ccccc2)c(C2CC2)s1.,Brc1cc(-c2ccccc2)c(C2CC2)s1,hydroxyl
123020,Please add a nitro to the molecule Cc1nc2sccc2c(=O)n1NC(=O)c1cccc2ncccc12.,Cc1nc2sccc2c(=O)n1NC(=O)c1cccc2ncccc12,nitro
202776,Please add a hydroxyl to the molecule CN(C)C(=O)CN(C)C(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1.,CN(C)C(=O)CN(C)C(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1,hydroxyl
106040,Add a amide to the molecule O=C(Nc1cccc(OC(F)F)c1)N[C@@H]1CC[NH+](Cc2ccccc2)C[C@H]1CO.,O=C(Nc1cccc(OC(F)F)c1)N[C@@H]1CC[NH+](Cc2ccccc2)C[C@H]1CO,amide
147646,Add a halo to the molecule COc1ccc(N(C(=O)Nc2cccc([N+](=O)[O-])c2)[C@@H](C)C2CC2)cc1.,COc1ccc(N(C(=O)Nc2cccc([N+](=O)[O-])c2)[C@@H](C)C2CC2)cc1,halo
199779,Add a benzene ring to the molecule C[NH+](C)CCNc1cc(-c2ccc3ncnc(N)c3c2)c2cc[nH]c2n1.,C[NH+](C)CCNc1cc(-c2ccc3ncnc(N)c3c2)c2cc[nH]c2n1,benzene ring
78569,Add a benzene ring to the molecule Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1.,Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1,benzene ring
79988,Modify the molecule COc1ccc(NC(C)=O)cc1NC(=O)CCC1CCCCC1 by adding a hydroxyl.,COc1ccc(NC(C)=O)cc1NC(=O)CCC1CCCCC1,hydroxyl
104536,Add a hydroxyl to the molecule CO[C@@H](CNC(=O)C[C@@H](O)c1ccc(Cl)cc1)C(C)(C)C.,CO[C@@H](CNC(=O)C[C@@H](O)c1ccc(Cl)cc1)C(C)(C)C,hydroxyl
177480,Please add a amide to the molecule COc1ccc(CC(=O)NCC#CCOc2cccc3ccccc23)cc1.,COc1ccc(CC(=O)NCC#CCOc2cccc3ccccc23)cc1,amide
91943,Please add a amide to the molecule Cc1ncsc1CCS(=O)(=O)c1nccn1-c1cccc(F)c1.,Cc1ncsc1CCS(=O)(=O)c1nccn1-c1cccc(F)c1,amide
85559,Please add a hydroxyl to the molecule CCOc1ccccc1NS(=O)(=O)c1ccc(C)c(C)c1.,CCOc1ccccc1NS(=O)(=O)c1ccc(C)c(C)c1,hydroxyl
223596,Modify the molecule Cn1ncc(Cl)c1C(=O)N1CCCCC[C@H]1c1cc(-c2cccs2)on1 by adding a amine.,Cn1ncc(Cl)c1C(=O)N1CCCCC[C@H]1c1cc(-c2cccs2)on1,amine
94153,Please add a hydroxyl to the molecule CN(c1nc(Cl)ncc1F)C1CCOCC1.,CN(c1nc(Cl)ncc1F)C1CCOCC1,hydroxyl
176341,Add a halo to the molecule COCc1nn2c(ncc3c(=O)n(Cc4ccccc4)ccc32)c1-c1ccc(F)cc1.,COCc1nn2c(ncc3c(=O)n(Cc4ccccc4)ccc32)c1-c1ccc(F)cc1,halo
137172,Modify the molecule O=C(COc1ccc2cc(-c3cc(F)cc(F)c3)c(=O)oc2c1)Nc1cccnc1 by adding a nitro.,O=C(COc1ccc2cc(-c3cc(F)cc(F)c3)c(=O)oc2c1)Nc1cccnc1,nitro
35201,Modify the molecule O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1 by adding a benzene ring.,O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1,benzene ring
31986,Add a hydroxyl to the molecule [NH3+][C@H]1CCC[C@@H]1CNC(=O)CC12CC3CC(CC(C3)C1)C2.,[NH3+][C@H]1CCC[C@@H]1CNC(=O)CC12CC3CC(CC(C3)C1)C2,hydroxyl
45656,Modify the molecule CCCS(=O)(=O)N1CCC[C@H]1C(=O)NCC[NH+]1CCCCC1 by adding a aldehyde.,CCCS(=O)(=O)N1CCC[C@H]1C(=O)NCC[NH+]1CCCCC1,aldehyde
171261,Add a benzene ring to the molecule CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1.,CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1,benzene ring
76256,Modify the molecule O=C(Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](c1ccccc1)C1CC1 by adding a carboxyl.,O=C(Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](c1ccccc1)C1CC1,carboxyl
209948,Modify the molecule CCN(C(=O)c1cc(C)n(-c2ccccc2)n1)c1cccc(F)c1 by adding a amine.,CCN(C(=O)c1cc(C)n(-c2ccccc2)n1)c1cccc(F)c1,amine
135184,Modify the molecule Cc1cc(O[C@H](C)C(=O)Nc2cnn(C)c2)ccc1C(C)C by adding a halo.,Cc1cc(O[C@H](C)C(=O)Nc2cnn(C)c2)ccc1C(C)C,halo
171049,Please add a hydroxyl to the molecule COC(=O)c1cc(O)n(-c2cc(Cl)cc(Cl)c2)n1.,COC(=O)c1cc(O)n(-c2cc(Cl)cc(Cl)c2)n1,hydroxyl
145151,Please add a aldehyde to the molecule O=C(c1ccc2[nH]cnc2c1)N1CCn2c1nc1ccccc12.,O=C(c1ccc2[nH]cnc2c1)N1CCn2c1nc1ccccc12,aldehyde
169661,Please add a amine to the molecule Cc1ccc(/C=C/C(=O)NC[C@H](C2CC2)[NH+](C)C)cc1.,Cc1ccc(/C=C/C(=O)NC[C@H](C2CC2)[NH+](C)C)cc1,amine
146572,Please add a benzene ring to the molecule O=C(NCCc1ccccn1)Nc1nccs1.,O=C(NCCc1ccccn1)Nc1nccs1,benzene ring
239467,Modify the molecule CCCn1c(=O)n(CC(=O)Nc2ncc(C)s2)c2ccccc21 by adding a amine.,CCCn1c(=O)n(CC(=O)Nc2ncc(C)s2)c2ccccc21,amine
16973,Modify the molecule Cc1n[nH]c(C(=O)N(C)CC(=O)[O-])n1 by adding a carboxyl.,Cc1n[nH]c(C(=O)N(C)CC(=O)[O-])n1,carboxyl
21642,Modify the molecule C[C@H](NCc1cccc(N(C)C)[nH+]1)c1ccc(S(=O)(=O)N(C)C)cc1 by adding a hydroxyl.,C[C@H](NCc1cccc(N(C)C)[nH+]1)c1ccc(S(=O)(=O)N(C)C)cc1,hydroxyl
115574,Add a carboxyl to the molecule CSC[C@H](C)N(C)C(=O)Nc1ccccc1C(=O)N1CCC(C)CC1.,CSC[C@H](C)N(C)C(=O)Nc1ccccc1C(=O)N1CCC(C)CC1,carboxyl
173196,Please add a nitro to the molecule CCOC(=O)c1cccc(-n2nnc3c(sc4nc(C)cc(COC)c43)c2=O)c1.,CCOC(=O)c1cccc(-n2nnc3c(sc4nc(C)cc(COC)c43)c2=O)c1,nitro
59020,Please add a amide to the molecule CCCC(=O)/N=c1\sc2cc(OC)ccc2n1CCSC.,CCCC(=O)/N=c1\sc2cc(OC)ccc2n1CCSC,amide
192067,Add a amide to the molecule Cc1cc(N(C)C(=O)c2ccc(F)cc2O)ccc1Br.,Cc1cc(N(C)C(=O)c2ccc(F)cc2O)ccc1Br,amide
24258,Add a amine to the molecule CC[C@@](C)(NS(=O)(=O)c1ccc(F)c(F)c1)C(=O)[O-].,CC[C@@](C)(NS(=O)(=O)c1ccc(F)c(F)c1)C(=O)[O-],amine
191561,Modify the molecule COc1cccc(C(=O)Nc2ccc3c(c2)C(=[N+]2CCOCC2)Nc2cc(Cl)ccc2O3)c1 by adding a hydroxyl.,COc1cccc(C(=O)Nc2ccc3c(c2)C(=[N+]2CCOCC2)Nc2cc(Cl)ccc2O3)c1,hydroxyl
142648,Modify the molecule N#Cc1ccc(OCCNC(=O)NCCc2cccc(O)c2)cc1 by adding a hydroxyl.,N#Cc1ccc(OCCNC(=O)NCCc2cccc(O)c2)cc1,hydroxyl
49104,Add a benzene ring to the molecule CC1=C(C(=O)OC(C)C)[C@@H](C)N=C1C(=O)Nc1ccc2c(c1)NC(=O)[C@@H](C)O2.,CC1=C(C(=O)OC(C)C)[C@@H](C)N=C1C(=O)Nc1ccc2c(c1)NC(=O)[C@@H](C)O2,benzene ring
237523,Modify the molecule O=C(CSC1=NC(=O)C2=C3CCCC[C@H]3SC2=N1)Nc1nnc(C2CC2)s1 by adding a nitro.,O=C(CSC1=NC(=O)C2=C3CCCC[C@H]3SC2=N1)Nc1nnc(C2CC2)s1,nitro
15671,Please add a nitrile to the molecule CCN(CC)C(=O)N1CCc2cc(OC)c(OC)cc2[C@H]1c1cc2cc(C)cc(C)c2[nH]c1=O.,CCN(CC)C(=O)N1CCc2cc(OC)c(OC)cc2[C@H]1c1cc2cc(C)cc(C)c2[nH]c1=O,nitrile
187296,Please add a aldehyde to the molecule Cc1cccc(OC[C@@H](O)CN2CCN(Cc3[nH+]ccn3C)CC2)c1.,Cc1cccc(OC[C@@H](O)CN2CCN(Cc3[nH+]ccn3C)CC2)c1,aldehyde
186833,Modify the molecule Cc1cc(C(=O)NC2CC[NH+](Cc3cnc4cnccn34)CC2)c(C)o1 by adding a nitro.,Cc1cc(C(=O)NC2CC[NH+](Cc3cnc4cnccn34)CC2)c(C)o1,nitro
229818,Add a nitro to the molecule CCOC(=O)N/N=C(\C)c1cccc(NC(=O)C2CCCCC2)c1.,CCOC(=O)N/N=C(\C)c1cccc(NC(=O)C2CCCCC2)c1,nitro
3225,Please add a amide to the molecule CC1(C)CN(CC(=O)N2CCCC2)c2ccc(S(=O)(=O)Nc3ccc4c(c3)OCCO4)cc21.,CC1(C)CN(CC(=O)N2CCCC2)c2ccc(S(=O)(=O)Nc3ccc4c(c3)OCCO4)cc21,amide
193803,Please add a hydroxyl to the molecule CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2ccc(-c3cc[nH]n3)cc2)C1.,CC(C)(C)OC(=O)N1CC[C@H](C(=O)Nc2ccc(-c3cc[nH]n3)cc2)C1,hydroxyl
236109,Add a carboxyl to the molecule Cc1n[nH]c(C)c1C[C@H](C)C(=O)N[C@@H](C)c1ccc(-c2cccnc2)cc1.,Cc1n[nH]c(C)c1C[C@H](C)C(=O)N[C@@H](C)c1ccc(-c2cccnc2)cc1,carboxyl
81826,Add a halo to the molecule CN(C[C@H](O)C1CC1)C(=O)c1ccc(NC2CC2)c([N+](=O)[O-])c1.,CN(C[C@H](O)C1CC1)C(=O)c1ccc(NC2CC2)c([N+](=O)[O-])c1,halo
11924,Please add a hydroxyl to the molecule CCCc1nc(CO/N=C(/N)c2cccs2)no1.,CCCc1nc(CO/N=C(/N)c2cccs2)no1,hydroxyl
143232,Modify the molecule CC(C)[NH+]1CCCC[C@H]1CCn1cnc2ccccc2c1=O by adding a benzene ring.,CC(C)[NH+]1CCCC[C@H]1CCn1cnc2ccccc2c1=O,benzene ring
191277,Modify the molecule O=C1OCC[C@H]1N1CCC(C(=O)N2CCCCC2)CC1 by adding a nitro.,O=C1OCC[C@H]1N1CCC(C(=O)N2CCCCC2)CC1,nitro
111356,Please add a hydroxyl to the molecule O=C(CCc1nc(-c2ccncc2)no1)N[C@@H]1CCS(=O)(=O)C1.,O=C(CCc1nc(-c2ccncc2)no1)N[C@@H]1CCS(=O)(=O)C1,hydroxyl
173100,Please add a nitro to the molecule COc1cccc(NC(=O)CSc2nccnc2N2CCN(c3ccccc3)CC2)c1.,COc1cccc(NC(=O)CSc2nccnc2N2CCN(c3ccccc3)CC2)c1,nitro
233647,Modify the molecule C[C@H](c1ccc(F)cc1)N(C)C(=O)Cc1csc(-c2ccccn2)n1 by adding a benzene ring.,C[C@H](c1ccc(F)cc1)N(C)C(=O)Cc1csc(-c2ccccn2)n1,benzene ring
23416,Add a amine to the molecule Cc1cc2c(c(=O)n1CC[NH+](C)C)[C@@]1(C(=O)N(CC(C)C)c3ccccc31)C(C#N)=C(N)O2.,Cc1cc2c(c(=O)n1CC[NH+](C)C)[C@@]1(C(=O)N(CC(C)C)c3ccccc31)C(C#N)=C(N)O2,amine
160633,Please add a amine to the molecule C[C@@H](C(=O)Nc1cccc(C#N)c1)N1CCN(S(C)(=O)=O)CC1.,C[C@@H](C(=O)Nc1cccc(C#N)c1)N1CCN(S(C)(=O)=O)CC1,amine
169706,Add a amide to the molecule COc1ccc(C)cc1NC(=O)c1oc2c(c1C)/C(=N/NC(=O)c1ccc(C)cc1)CCC2.,COc1ccc(C)cc1NC(=O)c1oc2c(c1C)/C(=N/NC(=O)c1ccc(C)cc1)CCC2,amide
65337,Add a benzene ring to the molecule O=C(Nc1cccc([N+](=O)[O-])c1)C(=O)N1CCO[C@@H](c2cccc(F)c2)C1.,O=C(Nc1cccc([N+](=O)[O-])c1)C(=O)N1CCO[C@@H](c2cccc(F)c2)C1,benzene ring
29726,Modify the molecule CC(C)NC(=O)N1CCC[NH+](Cc2ccccn2)CC1 by adding a nitro.,CC(C)NC(=O)N1CCC[NH+](Cc2ccccn2)CC1,nitro
86202,Add a halo to the molecule CC(=O)Nc1cccc(C(=O)N(C)[C@@H](C)c2ccc(F)cc2)c1.,CC(=O)Nc1cccc(C(=O)N(C)[C@@H](C)c2ccc(F)cc2)c1,halo
58015,Add a amine to the molecule CCOC(=O)c1sc(NC(=O)c2cc3ccc(OC)cc3[nH]2)nc1C.,CCOC(=O)c1sc(NC(=O)c2cc3ccc(OC)cc3[nH]2)nc1C,amine
24185,Modify the molecule O=C(NCc1ccc2c(c1)OCO2)N1CCC(n2cccc2)CC1 by adding a benzene ring.,O=C(NCc1ccc2c(c1)OCO2)N1CCC(n2cccc2)CC1,benzene ring
128137,Add a hydroxyl to the molecule Cc1c(C(=O)N2CCC[C@]3(CC=CCC3)C2)cnn1-c1ccccn1.,Cc1c(C(=O)N2CCC[C@]3(CC=CCC3)C2)cnn1-c1ccccn1,hydroxyl
23148,Modify the molecule O=C(Nc1ccccc1)c1nnc([C@H]2CCCN(C(=O)Nc3ccc(F)cc3)C2)s1 by adding a amide.,O=C(Nc1ccccc1)c1nnc([C@H]2CCCN(C(=O)Nc3ccc(F)cc3)C2)s1,amide
97646,Modify the molecule CC(C)Nc1cc(-n2ccnc2)ncn1 by adding a halo.,CC(C)Nc1cc(-n2ccnc2)ncn1,halo
191090,Please add a benzene ring to the molecule CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1.,CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1,benzene ring
13006,Please add a benzene ring to the molecule Cc1ccc(N2CC[C@H](NC(=O)N3CCC([C@H](C)O)CC3)C2=O)cc1.,Cc1ccc(N2CC[C@H](NC(=O)N3CCC([C@H](C)O)CC3)C2=O)cc1,benzene ring
155850,Please add a carboxyl to the molecule CCN(CC(C)(C)O)C(=O)Nc1cccc([C@H](C)[NH3+])c1.,CCN(CC(C)(C)O)C(=O)Nc1cccc([C@H](C)[NH3+])c1,carboxyl
17685,Please add a carboxyl to the molecule COCC[NH+]1CCCN(C(=O)c2ccccc2)CC1.,COCC[NH+]1CCCN(C(=O)c2ccccc2)CC1,carboxyl
194509,Add a benzene ring to the molecule CC[C@@H]1CCC[C@@](Cc2ccccn2)(C(=O)[O-])C1.,CC[C@@H]1CCC[C@@](Cc2ccccn2)(C(=O)[O-])C1,benzene ring
223807,Please add a benzene ring to the molecule COc1ccc2nc(Cl)c([C@@H]3CC(c4ccco4)=NN3S(=O)(=O)c3ccccc3)cc2c1.,COc1ccc2nc(Cl)c([C@@H]3CC(c4ccco4)=NN3S(=O)(=O)c3ccccc3)cc2c1,benzene ring
89147,Modify the molecule Cc1ccc2oc3c(c(=O)c2c1)[C@H](c1ccc(Cl)c(Cl)c1)N(CC[NH+](C)C)C3=O by adding a halo.,Cc1ccc2oc3c(c(=O)c2c1)[C@H](c1ccc(Cl)c(Cl)c1)N(CC[NH+](C)C)C3=O,halo
71231,Please add a benzene ring to the molecule Cc1noc(-c2ccnc(N[C@H](C)Cc3c(C)noc3C)c2)n1.,Cc1noc(-c2ccnc(N[C@H](C)Cc3c(C)noc3C)c2)n1,benzene ring
166765,Modify the molecule CCCOc1ccc([C@H]2[C@H]3CN(C(C)C)CC=C3C(C#N)=C(N)C2(C#N)C#N)cc1OCC by adding a hydroxyl.,CCCOc1ccc([C@H]2[C@H]3CN(C(C)C)CC=C3C(C#N)=C(N)C2(C#N)C#N)cc1OCC,hydroxyl
142243,Please add a benzene ring to the molecule O=C(NCc1ccc(F)cc1)Nc1ccc(Br)cc1.,O=C(NCc1ccc(F)cc1)Nc1ccc(Br)cc1,benzene ring
54852,Add a amide to the molecule C[NH+](C1CCCC1)[C@H]1CCCC(C)(C)[C@H]1O.,C[NH+](C1CCCC1)[C@H]1CCCC(C)(C)[C@H]1O,amide
78235,Please add a carboxyl to the molecule Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N.,Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N,carboxyl
23312,Modify the molecule CC(C)[C@H](N[C@H](C)C(=O)NC(N)=O)c1ccccc1 by adding a amine.,CC(C)[C@H](N[C@H](C)C(=O)NC(N)=O)c1ccccc1,amine
221252,Please add a benzene ring to the molecule Cc1ccc(NC(=O)CN(C)C(=O)CSc2nc(C(F)(F)F)nc3ccccc23)cc1.,Cc1ccc(NC(=O)CN(C)C(=O)CSc2nc(C(F)(F)F)nc3ccccc23)cc1,benzene ring
83808,Modify the molecule Cc1ccc(NC(=O)C(C)(C)c2cccc(Cl)c2)cc1C(=O)N(C)C by adding a amide.,Cc1ccc(NC(=O)C(C)(C)c2cccc(Cl)c2)cc1C(=O)N(C)C,amide
140638,Modify the molecule O=S(=O)(c1c[nH]c2ncccc12)N1CCN([C@@H]2CCCC[C@H]2O)CC1 by adding a hydroxyl.,O=S(=O)(c1c[nH]c2ncccc12)N1CCN([C@@H]2CCCC[C@H]2O)CC1,hydroxyl
58880,Please add a nitro to the molecule CO[C@@H](C)c1cccc(NC(=O)c2cc(S(=O)(=O)N(C)C)c(C)o2)c1.,CO[C@@H](C)c1cccc(NC(=O)c2cc(S(=O)(=O)N(C)C)c(C)o2)c1,nitro
151721,Add a amide to the molecule COc1ccccc1[C@H]1C(C#N)=C(N)Oc2cc3c(cc21)OCO3.,COc1ccccc1[C@H]1C(C#N)=C(N)Oc2cc3c(cc21)OCO3,amide
223249,Modify the molecule O=c1cc(CSCc2coc(-c3ccc(F)cc3)n2)nc2sccn12 by adding a benzene ring.,O=c1cc(CSCc2coc(-c3ccc(F)cc3)n2)nc2sccn12,benzene ring
85182,Please add a amide to the molecule CN(CCc1ccccn1)c1ncc(-c2ccncc2)c(-c2cccs2)n1.,CN(CCc1ccccn1)c1ncc(-c2ccncc2)c(-c2cccs2)n1,amide
237439,Please add a hydroxyl to the molecule COc1cc(C=C2C(=O)OC3(CCCC3)OC2=O)cc(Br)c1OC(C)=O.,COc1cc(C=C2C(=O)OC3(CCCC3)OC2=O)cc(Br)c1OC(C)=O,hydroxyl
208543,Please add a carboxyl to the molecule CCC[NH+](C)C[C@H]1CCN(C(=O)Cc2ccc(F)cc2)C1.,CCC[NH+](C)C[C@H]1CCN(C(=O)Cc2ccc(F)cc2)C1,carboxyl
133028,Modify the molecule CCn1c(SCC(=O)c2ccc3ccccc3c2)nnc1-c1cccs1 by adding a hydroxyl.,CCn1c(SCC(=O)c2ccc3ccccc3c2)nnc1-c1cccs1,hydroxyl
196390,Please add a aldehyde to the molecule CC(C)CO[C@@H](C)c1noc(C[NH+](C)[C@@H]2CCS(=O)(=O)C2)n1.,CC(C)CO[C@@H](C)c1noc(C[NH+](C)[C@@H]2CCS(=O)(=O)C2)n1,aldehyde
64473,Add a hydroxyl to the molecule C[NH2+][C@@H](C)c1ccccc1O[C@H](C)C(=O)N(C)C.,C[NH2+][C@@H](C)c1ccccc1O[C@H](C)C(=O)N(C)C,hydroxyl
153410,Add a benzene ring to the molecule O=C(C[C@@H]1OCCc2ccsc21)N1CCN(CCO)CC1.,O=C(C[C@@H]1OCCc2ccsc21)N1CCN(CCO)CC1,benzene ring
75603,Please add a thiol to the molecule C[C@@H](Nc1ncccc1[N+](=O)[O-])C(=O)NC1CCCC1.,C[C@@H](Nc1ncccc1[N+](=O)[O-])C(=O)NC1CCCC1,thiol
90556,Please add a halo to the molecule O=C([O-])COc1ccc(-c2cc3cc(Br)ccc3oc2=O)cc1.,O=C([O-])COc1ccc(-c2cc3cc(Br)ccc3oc2=O)cc1,halo
45610,Modify the molecule Cc1n[nH]c2ncc(NC(=O)NCc3ccnc(OCC4CC4)c3)cc12 by adding a benzene ring.,Cc1n[nH]c2ncc(NC(=O)NCc3ccnc(OCC4CC4)c3)cc12,benzene ring
46850,Modify the molecule O=C(Nc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1c1cccnc1 by adding a aldehyde.,O=C(Nc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1c1cccnc1,aldehyde
189993,Please add a halo to the molecule CCOc1ccc([C@@H]([NH3+])c2cc(F)cc(F)c2)c(Br)c1.,CCOc1ccc([C@@H]([NH3+])c2cc(F)cc(F)c2)c(Br)c1,halo
107420,Modify the molecule Cc1[nH]c(C(=O)N2CCC[C@H]2c2nc3ccccc3[nH]2)c(C)c1C(=O)OC(C)C by adding a hydroxyl.,Cc1[nH]c(C(=O)N2CCC[C@H]2c2nc3ccccc3[nH]2)c(C)c1C(=O)OC(C)C,hydroxyl
84529,Modify the molecule COc1ccc(F)cc1NC(=O)C(=O)N1CCC[NH+](Cc2ccccc2)CC1 by adding a hydroxyl.,COc1ccc(F)cc1NC(=O)C(=O)N1CCC[NH+](Cc2ccccc2)CC1,hydroxyl
239921,Add a hydroxyl to the molecule C[C@H](O)C[NH+](Cc1cc2ccccc2[nH]c1=O)C1CCCCC1.,C[C@H](O)C[NH+](Cc1cc2ccccc2[nH]c1=O)C1CCCCC1,hydroxyl
214658,Add a halo to the molecule CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1.,CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1,halo
54349,Modify the molecule Cc1cc2nc(/C(C#N)=C/C=C/c3ccccc3)[nH]c2cc1C by adding a amide.,Cc1cc2nc(/C(C#N)=C/C=C/c3ccccc3)[nH]c2cc1C,amide
93660,Modify the molecule CCOC(=O)[C@H](C)N(C)CC1=Cc2ccccc2OC1 by adding a benzene ring.,CCOC(=O)[C@H](C)N(C)CC1=Cc2ccccc2OC1,benzene ring
117467,Please add a benzene ring to the molecule O=C(Nc1nc2cc3c(cc2s1)OCO3)c1ccc([N+](=O)[O-])s1.,O=C(Nc1nc2cc3c(cc2s1)OCO3)c1ccc([N+](=O)[O-])s1,benzene ring
144088,Add a carboxyl to the molecule Cc1cnn([C@H](C)C2CC2)c1NC(=O)c1ccc(-c2ncn[nH]2)cc1.,Cc1cnn([C@H](C)C2CC2)c1NC(=O)c1ccc(-c2ncn[nH]2)cc1,carboxyl
22085,Modify the molecule CC1(C)NC(=O)N(CC(=O)NCCc2cn3ccccc3[nH+]2)C1=O by adding a benzene ring.,CC1(C)NC(=O)N(CC(=O)NCCc2cn3ccccc3[nH+]2)C1=O,benzene ring
170908,Add a benzene ring to the molecule COc1ccc(C(=O)N[C@@H]2CCSc3ccccc32)cc1S(=O)(=O)N1CCCC[C@@H]1C.,COc1ccc(C(=O)N[C@@H]2CCSc3ccccc32)cc1S(=O)(=O)N1CCCC[C@@H]1C,benzene ring
22940,Add a aldehyde to the molecule COc1ccc(F)cc1NC(=O)Nc1cnn(CCO)c1.,COc1ccc(F)cc1NC(=O)Nc1cnn(CCO)c1,aldehyde
122184,Add a benzene ring to the molecule O=C(/C=C\c1cccs1)Nc1ccc(-c2cc[nH]n2)cc1.,O=C(/C=C\c1cccs1)Nc1ccc(-c2cc[nH]n2)cc1,benzene ring
175955,Please add a benzene ring to the molecule CC(C)NC(=O)[C@H](C)Sc1c(Cl)cccc1Cl.,CC(C)NC(=O)[C@H](C)Sc1c(Cl)cccc1Cl,benzene ring
221778,Please add a benzene ring to the molecule CCOc1cc([C@@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)ccc1OCC[NH+]1CCOCC1.,CCOc1cc([C@@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)ccc1OCC[NH+]1CCOCC1,benzene ring
96328,Please add a amide to the molecule Cn1cc(N2CC[C@@H](Nc3ccc(CO)cc3)C2=O)cn1.,Cn1cc(N2CC[C@@H](Nc3ccc(CO)cc3)C2=O)cn1,amide
191117,Add a hydroxyl to the molecule COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O.,COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O,hydroxyl
219807,Add a hydroxyl to the molecule COC(=O)[C@@H](c1cccc(C#N)c1)N(C)Cc1ccccc1.,COC(=O)[C@@H](c1cccc(C#N)c1)N(C)Cc1ccccc1,hydroxyl
189338,Please add a benzene ring to the molecule CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)Nc2nc3c(s2)CCCC3)c1.,CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)Nc2nc3c(s2)CCCC3)c1,benzene ring
57571,Add a hydroxyl to the molecule CCOC(=O)NCCC(=O)N1CCC[C@H]2CCCC[C@H]21.,CCOC(=O)NCCC(=O)N1CCC[C@H]2CCCC[C@H]21,hydroxyl
153800,Modify the molecule Cc1cc(C)c(O)c(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)c1 by adding a carboxyl.,Cc1cc(C)c(O)c(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)c1,carboxyl
96324,Please add a halo to the molecule CC[C@H](C)C(=O)N1CCC[C@@H](C(=O)N[C@@H](C)c2ccc(C)c(F)c2)C1.,CC[C@H](C)C(=O)N1CCC[C@@H](C(=O)N[C@@H](C)c2ccc(C)c(F)c2)C1,halo
113751,Modify the molecule c1cc(-c2nc(CN3CCCC4(C3)OCCO4)no2)cs1 by adding a amide.,c1cc(-c2nc(CN3CCCC4(C3)OCCO4)no2)cs1,amide
73638,Modify the molecule Cn1ncc2c(N3CCCC3)nc(N3CCN(c4ccccc4)CC3)nc21 by adding a hydroxyl.,Cn1ncc2c(N3CCCC3)nc(N3CCN(c4ccccc4)CC3)nc21,hydroxyl
201027,Add a benzene ring to the molecule CCN(Cc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(Br)cc1Cl.,CCN(Cc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(Br)cc1Cl,benzene ring
185648,Modify the molecule COc1ccccc1CC(C)(C)C(=O)NC[C@@H](C)c1cccs1 by adding a hydroxyl.,COc1ccccc1CC(C)(C)C(=O)NC[C@@H](C)c1cccs1,hydroxyl
231090,Please add a halo to the molecule CCC[NH2+][C@H](C1C[C@@H](C)C[C@H](C)C1)[C@]1(C)CCCO1.,CCC[NH2+][C@H](C1C[C@@H](C)C[C@H](C)C1)[C@]1(C)CCCO1,halo
156385,Add a benzene ring to the molecule Cc1nc2ccccc2nc1S[C@H](C(N)=O)c1ccccc1.,Cc1nc2ccccc2nc1S[C@H](C(N)=O)c1ccccc1,benzene ring
167481,Please add a thiol to the molecule CC[C@@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1)C(=O)NC[C@@H]1CCCO1.,CC[C@@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1)C(=O)NC[C@@H]1CCCO1,thiol
69193,Please add a benzene ring to the molecule O=C(NC[C@H]1CCN(c2ccccc2)C1)C(=O)Nc1cc(F)cc(F)c1.,O=C(NC[C@H]1CCN(c2ccccc2)C1)C(=O)Nc1cc(F)cc(F)c1,benzene ring
176264,Please add a aldehyde to the molecule Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1cccc(C2OCCO2)c1.,Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1cccc(C2OCCO2)c1,aldehyde
64017,Please add a halo to the molecule CNC(=O)c1ccc(CN(C)C(=O)c2ccncc2F)cc1.,CNC(=O)c1ccc(CN(C)C(=O)c2ccncc2F)cc1,halo
4248,Modify the molecule CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1 by adding a nitro.,CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1,nitro
224666,Modify the molecule CCCOC[C@H]1O[C@H]2OC(C)(C)O[C@@H]2[C@H]2OC(C)(C)O[C@@H]21 by adding a hydroxyl.,CCCOC[C@H]1O[C@H]2OC(C)(C)O[C@@H]2[C@H]2OC(C)(C)O[C@@H]21,hydroxyl
11338,Add a nitro to the molecule N#Cc1ccc(Sc2nnc3ccccn23)cc1[N+](=O)[O-].,N#Cc1ccc(Sc2nnc3ccccn23)cc1[N+](=O)[O-],nitro
215716,Add a hydroxyl to the molecule Cc1cc(NC(=O)C(=O)N[C@H](C)CCC2CCCC2)c2ncccc2c1.,Cc1cc(NC(=O)C(=O)N[C@H](C)CCC2CCCC2)c2ncccc2c1,hydroxyl
77155,Add a carboxyl to the molecule CCCOc1ccccc1C(=O)N1C[C@@H]([NH+](C)C)[C@H](c2ccc(OC)cc2)C1.,CCCOc1ccccc1C(=O)N1C[C@@H]([NH+](C)C)[C@H](c2ccc(OC)cc2)C1,carboxyl
15794,Modify the molecule O=C(NC1CCCCC1)c1nc(N2CCCCCC2)c2oc3ccccc3c2n1 by adding a amine.,O=C(NC1CCCCC1)c1nc(N2CCCCCC2)c2oc3ccccc3c2n1,amine
109215,Please add a halo to the molecule N/C(CCCCNC(=O)N[C@@H]1CCOC1)=N/O.,N/C(CCCCNC(=O)N[C@@H]1CCOC1)=N/O,halo
248005,Please add a halo to the molecule NC(=O)c1ccc(/C=C/C(=O)N2CCN(Cc3ccccc3)CC2)cc1.,NC(=O)c1ccc(/C=C/C(=O)N2CCN(Cc3ccccc3)CC2)cc1,halo
532,Please add a hydroxyl to the molecule CN(CC1CCCC1)C(=O)C(=O)Nc1cccc(SC(F)F)c1.,CN(CC1CCCC1)C(=O)C(=O)Nc1cccc(SC(F)F)c1,hydroxyl
162903,Please add a amide to the molecule CC1=C[C@@H](C(=O)N2CC[C@]3(CCCN(Cc4cccc(F)c4F)C3=O)C2)N=N1.,CC1=C[C@@H](C(=O)N2CC[C@]3(CCCN(Cc4cccc(F)c4F)C3=O)C2)N=N1,amide
72034,Add a hydroxyl to the molecule Cc1cccc(O[C@@H](C)CNC(=O)[C@@H]2CCCN2C(N)=O)c1.,Cc1cccc(O[C@@H](C)CNC(=O)[C@@H]2CCCN2C(N)=O)c1,hydroxyl
242115,Modify the molecule CN(CC(=O)N1CCC2(CC1)OCCO2)c1ccc2ccccc2c1 by adding a benzene ring.,CN(CC(=O)N1CCC2(CC1)OCCO2)c1ccc2ccccc2c1,benzene ring
37944,Add a benzene ring to the molecule COc1ccc(C[NH2+]C[C@@H](O)c2ccc(OC)cc2)cc1.,COc1ccc(C[NH2+]C[C@@H](O)c2ccc(OC)cc2)cc1,benzene ring
208396,Add a nitro to the molecule O=S(=O)(C[C@H](Br)C(F)(F)F)c1cccc(F)c1.,O=S(=O)(C[C@H](Br)C(F)(F)F)c1cccc(F)c1,nitro
148108,Please add a aldehyde to the molecule COc1ccc(/C(C)=N\NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc1.,COc1ccc(/C(C)=N\NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc1,aldehyde
67926,Modify the molecule COCc1ccc(CNC(=O)c2ccc(CS(C)(=O)=O)cc2)cc1 by adding a benzene ring.,COCc1ccc(CNC(=O)c2ccc(CS(C)(=O)=O)cc2)cc1,benzene ring
14814,Please add a nitro to the molecule Cc1cc(CN2C[C@@H](C(N)=O)O[C@H](C)C2)c(C)n1C1CC1.,Cc1cc(CN2C[C@@H](C(N)=O)O[C@H](C)C2)c(C)n1C1CC1,nitro
102172,Please add a benzene ring to the molecule O=C(NCc1cn2ccsc2n1)c1cc(COc2ccc3c(c2)OCO3)[nH]n1.,O=C(NCc1cn2ccsc2n1)c1cc(COc2ccc3c(c2)OCO3)[nH]n1,benzene ring
183683,Modify the molecule O=c1c2c3nc4ccccc4nc3n(-c3cccc(C(F)(F)F)c3)c2ncn1C[C@@H]1CCCO1 by adding a amide.,O=c1c2c3nc4ccccc4nc3n(-c3cccc(C(F)(F)F)c3)c2ncn1C[C@@H]1CCCO1,amide
177400,Modify the molecule COC(=O)CN(C(C)C)S(=O)(=O)c1cc(N)c(Cl)cc1C by adding a benzene ring.,COC(=O)CN(C(C)C)S(=O)(=O)c1cc(N)c(Cl)cc1C,benzene ring
228852,Modify the molecule N#Cc1ccc(OC(F)F)c(NC(=O)c2cc3ccccc3oc2=O)c1 by adding a carboxyl.,N#Cc1ccc(OC(F)F)c(NC(=O)c2cc3ccccc3oc2=O)c1,carboxyl
212440,Please add a carboxyl to the molecule CCOCc1ccc(CNC(=O)C[NH+]2CCCC2)cc1.,CCOCc1ccc(CNC(=O)C[NH+]2CCCC2)cc1,carboxyl
100430,Add a benzene ring to the molecule CC[C@@](C)([NH3+])c1nc(C)c(-c2ccco2)[nH]1.,CC[C@@](C)([NH3+])c1nc(C)c(-c2ccco2)[nH]1,benzene ring
179009,Add a halo to the molecule COc1ccc(Cl)cc1-n1c(C)cc(/C=C2\C(=O)NC(=S)N(c3cccc(F)c3)C2=O)c1C.,COc1ccc(Cl)cc1-n1c(C)cc(/C=C2\C(=O)NC(=S)N(c3cccc(F)c3)C2=O)c1C,halo
113873,Modify the molecule CCc1ccc(C(C)(C)CNC(=O)/C=C/c2cncc(C(=O)NC)c2)cc1 by adding a benzene ring.,CCc1ccc(C(C)(C)CNC(=O)/C=C/c2cncc(C(=O)NC)c2)cc1,benzene ring
90881,Please add a carboxyl to the molecule CC(=O)Nc1cc(Cl)ccc1NC(=O)[C@H]1Cc2cc(C)c(C)cc2O1.,CC(=O)Nc1cc(Cl)ccc1NC(=O)[C@H]1Cc2cc(C)c(C)cc2O1,carboxyl
99974,Please add a hydroxyl to the molecule Cn1cc(S[C@@H]2CCC[C@]([NH2+]C3CC3)(C(=O)[O-])C2)cn1.,Cn1cc(S[C@@H]2CCC[C@]([NH2+]C3CC3)(C(=O)[O-])C2)cn1,hydroxyl
228407,Please add a hydroxyl to the molecule O=C(c1ccc(COc2ccc3ccccc3c2)o1)N1CCS(=O)(=O)CC1.,O=C(c1ccc(COc2ccc3ccccc3c2)o1)N1CCS(=O)(=O)CC1,hydroxyl
57048,Please add a halo to the molecule C[C@H](NC(=O)N[C@@H]1C[C@@H]1C1CCCCC1)c1nc(C(C)(C)C)no1.,C[C@H](NC(=O)N[C@@H]1C[C@@H]1C1CCCCC1)c1nc(C(C)(C)C)no1,halo
113382,Add a amide to the molecule Cc1c(O[C@@H](C)C(=O)NCCCN2CCCC2=O)ccc2c3c(c(=O)oc12)CCCC3.,Cc1c(O[C@@H](C)C(=O)NCCCN2CCCC2=O)ccc2c3c(c(=O)oc12)CCCC3,amide
48340,Add a benzene ring to the molecule Cc1c(C(=O)NCC2(C)CCCC2)cnn1-c1ccc([O-])nn1.,Cc1c(C(=O)NCC2(C)CCCC2)cnn1-c1ccc([O-])nn1,benzene ring
139169,Modify the molecule Cc1nc2cc(NC=C(C#N)C#N)ccc2n1-c1ccccc1 by adding a nitro.,Cc1nc2cc(NC=C(C#N)C#N)ccc2n1-c1ccccc1,nitro
76637,Add a nitrile to the molecule Cc1c(C(=O)CSc2nc3ncccn3n2)sc2ccccc12.,Cc1c(C(=O)CSc2nc3ncccn3n2)sc2ccccc12,nitrile
151957,Please add a benzene ring to the molecule C=C(C)C[C@@H]([NH2+]CC)c1ccc(OC)c(OC)c1.,C=C(C)C[C@@H]([NH2+]CC)c1ccc(OC)c(OC)c1,benzene ring
106266,Please add a nitro to the molecule CC(=O)c1cnc(NC[C@@H]2OCCc3ccccc32)nc1C.,CC(=O)c1cnc(NC[C@@H]2OCCc3ccccc32)nc1C,nitro
146018,Please add a nitro to the molecule N#C/C(=C/c1c[nH]nc1-c1cccc([N+](=O)[O-])c1)c1ccccc1.,N#C/C(=C/c1c[nH]nc1-c1cccc([N+](=O)[O-])c1)c1ccccc1,nitro
242690,Modify the molecule Cc1ccccc1CC[C@H]1CCCN(c2nccs2)C1 by adding a benzene ring.,Cc1ccccc1CC[C@H]1CCCN(c2nccs2)C1,benzene ring
87744,Modify the molecule Cc1c(F)cccc1NC(=O)N(C)C1CCCCCC1 by adding a amine.,Cc1c(F)cccc1NC(=O)N(C)C1CCCCCC1,amine
185729,Add a amine to the molecule C[C@@H](NC(=O)N1CCC(c2ccn[nH]2)CC1)[C@@H]1COc2ccccc21.,C[C@@H](NC(=O)N1CCC(c2ccn[nH]2)CC1)[C@@H]1COc2ccccc21,amine
168926,Modify the molecule CC(C)c1ccc(C(=O)N2CCC[C@@H](C(=O)[O-])C2)cc1 by adding a amine.,CC(C)c1ccc(C(=O)N2CCC[C@@H](C(=O)[O-])C2)cc1,amine
73144,Add a benzene ring to the molecule COC(=O)[C@H](C)N(Cc1ccccc1)C(=O)c1ccc(Cl)c(OC)c1.,COC(=O)[C@H](C)N(Cc1ccccc1)C(=O)c1ccc(Cl)c(OC)c1,benzene ring
9220,Please add a benzene ring to the molecule CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1.,CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1,benzene ring
229760,Please add a nitro to the molecule O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1ccc2noc(-c3ccccc3)c2c1.,O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1ccc2noc(-c3ccccc3)c2c1,nitro
175482,Modify the molecule COc1ccc(OC)c(CN2CCOc3c(cc(-c4ccc(C)s4)cc3OC)C2)c1 by adding a benzene ring.,COc1ccc(OC)c(CN2CCOc3c(cc(-c4ccc(C)s4)cc3OC)C2)c1,benzene ring
212481,Please add a hydroxyl to the molecule CSc1ccnc(-c2nc([O-])c3cc(F)c(F)cc3n2)c1.,CSc1ccnc(-c2nc([O-])c3cc(F)c(F)cc3n2)c1,hydroxyl
49796,Add a benzene ring to the molecule Cc1ccc(Cn2c([O-])c(C(N)=O)c3snnc3c2=O)cc1.,Cc1ccc(Cn2c([O-])c(C(N)=O)c3snnc3c2=O)cc1,benzene ring
31495,Modify the molecule COc1ccc(C(=O)N2C[C@@H](C[NH+]3CCCC3)C[C@@H](CO)C2)cc1 by adding a benzene ring.,COc1ccc(C(=O)N2C[C@@H](C[NH+]3CCCC3)C[C@@H](CO)C2)cc1,benzene ring
193395,Please add a hydroxyl to the molecule CC1(C)C[C@@H]([NH2+]Cc2cccc3c2OCO3)C(C)(C)O1.,CC1(C)C[C@@H]([NH2+]Cc2cccc3c2OCO3)C(C)(C)O1,hydroxyl
169056,Modify the molecule N#Cc1ccc(CNCc2ncc(-c3ccccc3)s2)c(F)c1 by adding a halo.,N#Cc1ccc(CNCc2ncc(-c3ccccc3)s2)c(F)c1,halo
28230,Add a hydroxyl to the molecule Cc1ccccc1[C@@H]1CN(C(=O)C(C)(C)C#N)[C@@H](C)CO1.,Cc1ccccc1[C@@H]1CN(C(=O)C(C)(C)C#N)[C@@H](C)CO1,hydroxyl
85799,Add a hydroxyl to the molecule CCSC[C@@H](C)N(C)c1ccc(S(C)(=O)=O)cc1[N+](=O)[O-].,CCSC[C@@H](C)N(C)c1ccc(S(C)(=O)=O)cc1[N+](=O)[O-],hydroxyl
1760,Please add a hydroxyl to the molecule COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N32)c(OC)c1.,COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CCO)CC(=O)N32)c(OC)c1,hydroxyl
99306,Modify the molecule Cc1ccc(NC(=O)[C@@H]2C(=O)C[C@](C)(O)[C@@H](C(=O)Nc3ccc(C)cc3C)[C@H]2c2ccncc2)c(C)c1 by adding a benzene ring.,Cc1ccc(NC(=O)[C@@H]2C(=O)C[C@](C)(O)[C@@H](C(=O)Nc3ccc(C)cc3C)[C@H]2c2ccncc2)c(C)c1,benzene ring
188090,Modify the molecule Cn1cccc1C(=O)C(=O)NCc1ccco1 by adding a benzene ring.,Cn1cccc1C(=O)C(=O)NCc1ccco1,benzene ring
43260,Add a benzene ring to the molecule CCCNC(=O)c1ccc(NC(=O)C(=O)N[C@H]2CC=CCC2)cc1Cl.,CCCNC(=O)c1ccc(NC(=O)C(=O)N[C@H]2CC=CCC2)cc1Cl,benzene ring
100838,Add a hydroxyl to the molecule CC(C)c1cccc(NS(=O)(=O)c2ccc3c(c2)NC(=O)CO3)c1.,CC(C)c1cccc(NS(=O)(=O)c2ccc3c(c2)NC(=O)CO3)c1,hydroxyl
53848,Modify the molecule [NH3+]CCn1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2CO)nn1 by adding a amine.,[NH3+]CCn1cc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2CO)nn1,amine
192097,Add a amide to the molecule O=C(Cn1cnc2ccccc2c1=O)N(Cc1ccccc1)Cc1ccco1.,O=C(Cn1cnc2ccccc2c1=O)N(Cc1ccccc1)Cc1ccco1,amide
8783,Add a benzene ring to the molecule O=C(CN(C[C@@H]1CCCO1)C(=O)c1cc2c(s1)CCCC2)N1CCCC1.,O=C(CN(C[C@@H]1CCCO1)C(=O)c1cc2c(s1)CCCC2)N1CCCC1,benzene ring
148068,Please add a benzene ring to the molecule CCC[C@@H]1CN(C(=O)c2ccc(CC)o2)CCO1.,CCC[C@@H]1CN(C(=O)c2ccc(CC)o2)CCO1,benzene ring
117356,Please add a amide to the molecule CC(C)C[NH2+]Cc1ncnn1[C@H]1CCOC2(CCCC2)C1.,CC(C)C[NH2+]Cc1ncnn1[C@H]1CCOC2(CCCC2)C1,amide
96532,Add a aldehyde to the molecule CC(C)C[NH+]1CCN(CCc2nc(-c3ccccc3)no2)CC1.,CC(C)C[NH+]1CCN(CCc2nc(-c3ccccc3)no2)CC1,aldehyde
28864,Add a amide to the molecule C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C.,C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C,amide
159290,Please add a amide to the molecule Cc1cc(C)c(C)c(S(=O)(=O)N2CCN(C(=O)Cc3cn4ccsc4n3)CC2)c1C.,Cc1cc(C)c(C)c(S(=O)(=O)N2CCN(C(=O)Cc3cn4ccsc4n3)CC2)c1C,amide
110757,Please add a hydroxyl to the molecule Cn1cccc1[C@H]1CC(c2ccccc2Cl)=NN1C(=O)C[NH+](C)Cc1ccccc1.,Cn1cccc1[C@H]1CC(c2ccccc2Cl)=NN1C(=O)C[NH+](C)Cc1ccccc1,hydroxyl
61784,Modify the molecule CC[NH+]1CCC[C@H]1CN(C)Cc1nnsc1NC by adding a halo.,CC[NH+]1CCC[C@H]1CN(C)Cc1nnsc1NC,halo
22587,Add a amide to the molecule Cc1cccc(C(=O)NCCc2csc(C(C)C)n2)c1[N+](=O)[O-].,Cc1cccc(C(=O)NCCc2csc(C(C)C)n2)c1[N+](=O)[O-],amide
143137,Add a nitro to the molecule C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccn1.,C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccn1,nitro
56110,Add a halo to the molecule COCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCCCC1.,COCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCCCC1,halo
78108,Modify the molecule Cc1cnc(Cl)nc1Sc1nc(N)cc(=O)[nH]1 by adding a hydroxyl.,Cc1cnc(Cl)nc1Sc1nc(N)cc(=O)[nH]1,hydroxyl
40788,Add a hydroxyl to the molecule Cc1ccc(C)c(NC(=O)Cc2csc(NC(=O)OCC(C)C)n2)c1.,Cc1ccc(C)c(NC(=O)Cc2csc(NC(=O)OCC(C)C)n2)c1,hydroxyl
126129,Please add a hydroxyl to the molecule C[C@@H](SCc1nc(N)nc(N(C)C)n1)C(=O)N(C)C.,C[C@@H](SCc1nc(N)nc(N(C)C)n1)C(=O)N(C)C,hydroxyl
119071,Add a benzene ring to the molecule CC[C@@H](NC(=O)c1ccccc1OC1CCN(S(C)(=O)=O)CC1)c1ccc(F)cc1.,CC[C@@H](NC(=O)c1ccccc1OC1CCN(S(C)(=O)=O)CC1)c1ccc(F)cc1,benzene ring
49821,Add a halo to the molecule C=C1c2ccccc2C=Cc2ccccc21.,C=C1c2ccccc2C=Cc2ccccc21,halo
95909,Please add a amine to the molecule CCN[C@@]1(C(=O)OC)CC[C@@H]([NH+]2CCC(OC)CC2)C1.,CCN[C@@]1(C(=O)OC)CC[C@@H]([NH+]2CCC(OC)CC2)C1,amine
29006,Modify the molecule Cc1onc(-c2c(F)cccc2Cl)c1C(=O)NCc1ccnc(OCc2ccccc2)c1 by adding a amide.,Cc1onc(-c2c(F)cccc2Cl)c1C(=O)NCc1ccnc(OCc2ccccc2)c1,amide
247135,Please add a hydroxyl to the molecule CCc1nn2c(=O)cc(COC(=O)CSc3ccc(C)cc3)nc2s1.,CCc1nn2c(=O)cc(COC(=O)CSc3ccc(C)cc3)nc2s1,hydroxyl
37312,Please add a hydroxyl to the molecule O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F.,O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F,hydroxyl
161004,Add a hydroxyl to the molecule NC(=O)c1cc(NC(=O)NC[C@@H](CCO)c2ccccc2)ccc1F.,NC(=O)c1cc(NC(=O)NC[C@@H](CCO)c2ccccc2)ccc1F,hydroxyl
76351,Modify the molecule Cc1nc(NC(=O)[C@@H](C)Sc2ccccn2)sc1C by adding a amide.,Cc1nc(NC(=O)[C@@H](C)Sc2ccccn2)sc1C,amide
27571,Modify the molecule C[C@@H]1CC[C@](O)(Cc2nc(-c3ccccc3)cs2)C1 by adding a aldehyde.,C[C@@H]1CC[C@](O)(Cc2nc(-c3ccccc3)cs2)C1,aldehyde
187824,Add a amide to the molecule CC(C)CNC(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C.,CC(C)CNC(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C,amide
69049,Add a aldehyde to the molecule CC(C)[C@H](C[NH3+])Nc1ncc(Cl)cc1F.,CC(C)[C@H](C[NH3+])Nc1ncc(Cl)cc1F,aldehyde
166369,Please add a benzene ring to the molecule C=CCOc1ccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)cc1.,C=CCOc1ccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)cc1,benzene ring
143901,Add a hydroxyl to the molecule COCCN(C)C(=O)Nc1cccc(COc2cccc(F)c2)c1.,COCCN(C)C(=O)Nc1cccc(COc2cccc(F)c2)c1,hydroxyl
156003,Modify the molecule CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)cc1 by adding a amide.,CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)cc1,amide
185892,Please add a benzene ring to the molecule COc1ccc2c(CC(=O)Nc3cc(Cl)ccc3Cl)coc2c1.,COc1ccc2c(CC(=O)Nc3cc(Cl)ccc3Cl)coc2c1,benzene ring
12672,Please add a amide to the molecule C[C@H]1CC=CC[C@H]1COC(=O)C(C)(C)S(=O)(=O)c1ccc(Br)cc1.,C[C@H]1CC=CC[C@H]1COC(=O)C(C)(C)S(=O)(=O)c1ccc(Br)cc1,amide
101113,Please add a amine to the molecule C[C@H]1C[C@@H]([NH2+]CCCc2ccc(Cl)cc2)CN1C.,C[C@H]1C[C@@H]([NH2+]CCCc2ccc(Cl)cc2)CN1C,amine
15765,Please add a benzene ring to the molecule CC[C@@H]1c2ccccc2CCN1C(=O)CN(C)S(=O)(=O)c1ccccc1.,CC[C@@H]1c2ccccc2CCN1C(=O)CN(C)S(=O)(=O)c1ccccc1,benzene ring
24862,Add a nitrile to the molecule CN(C(=O)[C@H]1CSCN1C(=O)[C@@H]1CCC(=O)N1)C1CCCCC1.,CN(C(=O)[C@H]1CSCN1C(=O)[C@@H]1CCC(=O)N1)C1CCCCC1,nitrile
86395,Please add a nitro to the molecule Cc1ccc([C@@H]2c3ccccc3CCN2C(=O)c2ccccc2F)cc1.,Cc1ccc([C@@H]2c3ccccc3CCN2C(=O)c2ccccc2F)cc1,nitro
194270,Add a aldehyde to the molecule CCSc1cncc(NC2CC(C)(C)[NH2+]C(C)(C)C2)n1.,CCSc1cncc(NC2CC(C)(C)[NH2+]C(C)(C)C2)n1,aldehyde
108823,Add a carboxyl to the molecule CCC[C@@H](C)Nc1nc2cc([N+](=O)[O-])ccc2[nH]1.,CCC[C@@H](C)Nc1nc2cc([N+](=O)[O-])ccc2[nH]1,carboxyl
42375,Modify the molecule COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC by adding a amide.,COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC,amide
171550,Please add a hydroxyl to the molecule CCOC(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1.,CCOC(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1,hydroxyl
193661,Please add a amide to the molecule CN(C(=O)c1ccc[nH]c1=O)[C@@H]1CCc2ccccc2C1.,CN(C(=O)c1ccc[nH]c1=O)[C@@H]1CCc2ccccc2C1,amide
877,Please add a nitro to the molecule CO[C@H](c1ccc(Cl)cc1)[C@@H](C)NC(=O)C(=O)Nc1ccccc1C.,CO[C@H](c1ccc(Cl)cc1)[C@@H](C)NC(=O)C(=O)Nc1ccccc1C,nitro
181062,Please add a amine to the molecule [NH3+]C1CCN(Cc2cc(Cl)ccn2)CC1.,[NH3+]C1CCN(Cc2cc(Cl)ccn2)CC1,amine
111372,Add a benzene ring to the molecule CC[C@H]1C[NH+](CCC(=O)NC(C)C)CCS1.,CC[C@H]1C[NH+](CCC(=O)NC(C)C)CCS1,benzene ring
175186,Please add a aldehyde to the molecule CCn1cc(C)c(C(=O)[O-])c1CC(=O)NCc1cccc(C)c1.,CCn1cc(C)c(C(=O)[O-])c1CC(=O)NCc1cccc(C)c1,aldehyde
165209,Please add a carboxyl to the molecule C[C@@H]1C[NH+](CCCCCO)C[C@H]1C.,C[C@@H]1C[NH+](CCCCCO)C[C@H]1C,carboxyl
153754,Modify the molecule O=C(N[C@@H]1CCc2cc(F)ccc21)c1cnc([C@@H]2CCCO2)s1 by adding a aldehyde.,O=C(N[C@@H]1CCc2cc(F)ccc21)c1cnc([C@@H]2CCCO2)s1,aldehyde
247165,Add a amide to the molecule C[NH+](C)CCNS(=O)(=O)C1=CN=C([C@H]2NN[C@H](c3ccc(F)cc3)O2)C1.,C[NH+](C)CCNS(=O)(=O)C1=CN=C([C@H]2NN[C@H](c3ccc(F)cc3)O2)C1,amide
70918,Modify the molecule Cc1cc(Br)ccc1NC(=O)CNC(=O)Nc1ccccc1 by adding a carboxyl.,Cc1cc(Br)ccc1NC(=O)CNC(=O)Nc1ccccc1,carboxyl
246002,Add a amide to the molecule CCC[NH+]1CCC(NC(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)CC1.,CCC[NH+]1CCC(NC(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)CC1,amide
26167,Modify the molecule CC(C)[C@@H]1N=N[C@H](NC(=O)CSC2[NH+]=c3ccccc3=[NH+]2)S1 by adding a nitro.,CC(C)[C@@H]1N=N[C@H](NC(=O)CSC2[NH+]=c3ccccc3=[NH+]2)S1,nitro
82181,Add a nitro to the molecule CC(C)CNC(=O)C1([NH2+]CCn2cccn2)CCCC1.,CC(C)CNC(=O)C1([NH2+]CCn2cccn2)CCCC1,nitro
171855,Please add a hydroxyl to the molecule C[C@@H](NC(=O)N1C[C@H]2CCCC[C@@H]2C1)c1ccc(S(C)(=O)=O)c(F)c1.,C[C@@H](NC(=O)N1C[C@H]2CCCC[C@@H]2C1)c1ccc(S(C)(=O)=O)c(F)c1,hydroxyl
51464,Modify the molecule CCS[C@H]1CCCCN(C(=O)[C@H](C)NC(=O)C(C)(C)C)C1 by adding a amide.,CCS[C@H]1CCCCN(C(=O)[C@H](C)NC(=O)C(C)(C)C)C1,amide
54736,Please add a aldehyde to the molecule CCCC(=O)N1CCC[C@@H](c2nc(Nc3ccccc3)cc(-c3cccnc3)n2)C1.,CCCC(=O)N1CCC[C@@H](c2nc(Nc3ccccc3)cc(-c3cccnc3)n2)C1,aldehyde
172207,Modify the molecule COc1ccc(/C=N/NC(=O)COc2ccccc2OC)cc1Br by adding a nitro.,COc1ccc(/C=N/NC(=O)COc2ccccc2OC)cc1Br,nitro
50094,Add a amine to the molecule COCc1c(C(=O)NCc2c(C)cc(C)[nH]c2=O)oc2ccccc12.,COCc1c(C(=O)NCc2c(C)cc(C)[nH]c2=O)oc2ccccc12,amine
51096,Please add a aldehyde to the molecule O=C(c1ccccc1Cl)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1.,O=C(c1ccccc1Cl)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1,aldehyde
177027,Please add a hydroxyl to the molecule C[C@@H](c1ccc(-n2cncn2)cc1)N(C)C(=O)CSCc1nc2ccccc2s1.,C[C@@H](c1ccc(-n2cncn2)cc1)N(C)C(=O)CSCc1nc2ccccc2s1,hydroxyl
122626,Please add a amide to the molecule C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1.,C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1,amide
240756,Modify the molecule Cc1cc(C)nc(N2CCC[C@H]([NH3+])C2)n1 by adding a hydroxyl.,Cc1cc(C)nc(N2CCC[C@H]([NH3+])C2)n1,hydroxyl
137862,Please add a nitro to the molecule Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C.,Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C,nitro
185395,Please add a benzene ring to the molecule C[C@@H]1C[C@H](Sc2nnc(N3CCCC3)n2Cc2ccco2)C(=O)O1.,C[C@@H]1C[C@H](Sc2nnc(N3CCCC3)n2Cc2ccco2)C(=O)O1,benzene ring
187407,Please add a hydroxyl to the molecule O=C(Oc1ccc2nccnc2c1)c1ccccc1-n1cccn1.,O=C(Oc1ccc2nccnc2c1)c1ccccc1-n1cccn1,hydroxyl
199075,Please add a amide to the molecule Cn1ncc(N2CC[C@@H](CNC(=O)c3c[nH]c(-c4ccccc4)n3)C2)cc1=O.,Cn1ncc(N2CC[C@@H](CNC(=O)c3c[nH]c(-c4ccccc4)n3)C2)cc1=O,amide
25743,Modify the molecule Cc1ccc2c(c1)-c1c(c(C(=O)Nc3ccc(F)cc3F)nn1C)CS2 by adding a hydroxyl.,Cc1ccc2c(c1)-c1c(c(C(=O)Nc3ccc(F)cc3F)nn1C)CS2,hydroxyl
9585,Modify the molecule COc1ccc(-c2ncc(C(=O)Nc3cc(OC)ccc3F)s2)cc1 by adding a carboxyl.,COc1ccc(-c2ncc(C(=O)Nc3cc(OC)ccc3F)s2)cc1,carboxyl
240042,Modify the molecule Cc1c(NC(=O)N(C)CC(=O)Nc2ccccc2)cccc1[N+](=O)[O-] by adding a benzene ring.,Cc1c(NC(=O)N(C)CC(=O)Nc2ccccc2)cccc1[N+](=O)[O-],benzene ring
231868,Add a hydroxyl to the molecule C[C@H]1CCCC[C@H]1NC(=O)CNC(=O)c1ccc(Br)o1.,C[C@H]1CCCC[C@H]1NC(=O)CNC(=O)c1ccc(Br)o1,hydroxyl
91876,Please add a halo to the molecule CCOc1ccc(Br)cc1C(=O)Nc1cccc(OC[C@H]2CCCO2)c1.,CCOc1ccc(Br)cc1C(=O)Nc1cccc(OC[C@H]2CCCO2)c1,halo
246683,Add a nitro to the molecule CCNC(=O)[C@H]1CCCN(C(=O)N[C@H](C)c2cc(C)sc2C)C1.,CCNC(=O)[C@H]1CCCN(C(=O)N[C@H](C)c2cc(C)sc2C)C1,nitro
149316,Please add a hydroxyl to the molecule O=C(NC1CCCC1)[C@H]1CCCN(c2nnc(N3CCCCC3=O)s2)C1.,O=C(NC1CCCC1)[C@H]1CCCN(c2nnc(N3CCCCC3=O)s2)C1,hydroxyl
150691,Modify the molecule Cc1cccc2sc(NC(=O)CN(C)c3nc4ccccc4s3)nc12 by adding a halo.,Cc1cccc2sc(NC(=O)CN(C)c3nc4ccccc4s3)nc12,halo
124624,Modify the molecule Cc1ncc(S(=O)(=O)Nc2[nH]nc(C)c2C)s1 by adding a amine.,Cc1ncc(S(=O)(=O)Nc2[nH]nc(C)c2C)s1,amine
117868,Add a carboxyl to the molecule C[NH2+]Cc1ccccc1OCc1cccc(C)c1.,C[NH2+]Cc1ccccc1OCc1cccc(C)c1,carboxyl
203210,Add a carboxyl to the molecule Cc1cc(C)n(Cc2ccc(C(=O)N3C[C@@H](C)OC[C@@H]3C)cc2)n1.,Cc1cc(C)n(Cc2ccc(C(=O)N3C[C@@H](C)OC[C@@H]3C)cc2)n1,carboxyl
136427,Modify the molecule Cc1cc(C)nc(N/C(=[NH+]\C(=O)NC23CC4CC(CC(C4)C2)C3)N2CCN(c3cccc[nH+]3)CC2)n1 by adding a halo.,Cc1cc(C)nc(N/C(=[NH+]\C(=O)NC23CC4CC(CC(C4)C2)C3)N2CCN(c3cccc[nH+]3)CC2)n1,halo
204735,Modify the molecule Cc1ccc(SCC[NH+]2CCC(CS(N)(=O)=O)CC2)cc1C by adding a benzene ring.,Cc1ccc(SCC[NH+]2CCC(CS(N)(=O)=O)CC2)cc1C,benzene ring
247404,Modify the molecule CCS(=O)(=O)N1CCCc2cc([N-]S(=O)(=O)c3cccc([N+](=O)[O-])c3)ccc21 by adding a aldehyde.,CCS(=O)(=O)N1CCCc2cc([N-]S(=O)(=O)c3cccc([N+](=O)[O-])c3)ccc21,aldehyde
963,Add a hydroxyl to the molecule Cc1cccc(C(C)C)c1NC(=O)[C@@H](C)Sc1nnc(-c2cccs2)n1N.,Cc1cccc(C(C)C)c1NC(=O)[C@@H](C)Sc1nnc(-c2cccs2)n1N,hydroxyl
169088,Add a amine to the molecule Cc1cn2c(CN(C)C(=O)CO[C@@H]3CCCC[C@@H]3C)c(C)nc2s1.,Cc1cn2c(CN(C)C(=O)CO[C@@H]3CCCC[C@@H]3C)c(C)nc2s1,amine
199378,Modify the molecule O=C(N/N=C/c1ccc([N+](=O)[O-])cc1)C(=O)Nc1cccc(F)c1 by adding a benzene ring.,O=C(N/N=C/c1ccc([N+](=O)[O-])cc1)C(=O)Nc1cccc(F)c1,benzene ring
142246,Add a halo to the molecule CCN(C[C@H]1CCOC1)C(=O)NCCCc1cccc(Br)c1.,CCN(C[C@H]1CCOC1)C(=O)NCCCc1cccc(Br)c1,halo
127240,Modify the molecule COc1ccc(CNC(=O)[C@H]2CCCN(S(=O)(=O)N3CCCCCC3)C2)cc1 by adding a carboxyl.,COc1ccc(CNC(=O)[C@H]2CCCN(S(=O)(=O)N3CCCCCC3)C2)cc1,carboxyl
127021,Add a carboxyl to the molecule O=C(CCC(=O)c1ccccc1)NC[C@H]1CCS(=O)(=O)C1.,O=C(CCC(=O)c1ccccc1)NC[C@H]1CCS(=O)(=O)C1,carboxyl
105682,Add a benzene ring to the molecule CCc1nnc(/N=C(\[O-])[C@H](C)[NH+]2CCc3ccccc3C2)s1.,CCc1nnc(/N=C(\[O-])[C@H](C)[NH+]2CCc3ccccc3C2)s1,benzene ring
67145,Modify the molecule COC[C@H](C)OC(=O)c1ncoc1C(C)C by adding a hydroxyl.,COC[C@H](C)OC(=O)c1ncoc1C(C)C,hydroxyl
134902,Modify the molecule Cc1cc([N+](=O)[O-])ccc1S(=O)(=O)Oc1ccccc1C(F)(F)F by adding a benzene ring.,Cc1cc([N+](=O)[O-])ccc1S(=O)(=O)Oc1ccccc1C(F)(F)F,benzene ring
126124,Please add a hydroxyl to the molecule Cc1ccc2[nH+]c3c(n2c1)[C@H](c1ccc(O)cc1Cl)CC(=O)NC3.,Cc1ccc2[nH+]c3c(n2c1)[C@H](c1ccc(O)cc1Cl)CC(=O)NC3,hydroxyl
171095,Modify the molecule CC(=O)N1CCCc2cc(NC(=O)NCC(C)(C)c3ccncc3)ccc21 by adding a aldehyde.,CC(=O)N1CCCc2cc(NC(=O)NCC(C)(C)c3ccncc3)ccc21,aldehyde
37608,Modify the molecule C[C@H]1C[C@@H]1C(=O)N1CCN(Cc2cnc[nH]2)CC1 by adding a amine.,C[C@H]1C[C@@H]1C(=O)N1CCN(Cc2cnc[nH]2)CC1,amine
67563,Modify the molecule COc1ccc(-c2csc(CN3CCN(C(=O)C4(c5cccs5)CCCC4)CC3)n2)cc1 by adding a hydroxyl.,COc1ccc(-c2csc(CN3CCN(C(=O)C4(c5cccs5)CCCC4)CC3)n2)cc1,hydroxyl
59821,Please add a hydroxyl to the molecule CCN(CC)c1cc(C2CC[NH+](C[C@H]3CC=CCC3)CC2)nc(-c2cnccn2)n1.,CCN(CC)c1cc(C2CC[NH+](C[C@H]3CC=CCC3)CC2)nc(-c2cnccn2)n1,hydroxyl
196247,Add a aldehyde to the molecule C[C@H]1OCC[C@H]1C(=O)Nc1ccsc1C(=O)[O-].,C[C@H]1OCC[C@H]1C(=O)Nc1ccsc1C(=O)[O-],aldehyde
70144,Modify the molecule CCOC(=O)c1ccccn1 by adding a carboxyl.,CCOC(=O)c1ccccn1,carboxyl
98237,Please add a hydroxyl to the molecule COc1ccc(Cl)cc1/N=C1/S[C@@H](CC(=O)Nc2ccc(C)cc2)C(=O)N1C.,COc1ccc(Cl)cc1/N=C1/S[C@@H](CC(=O)Nc2ccc(C)cc2)C(=O)N1C,hydroxyl
206468,Add a amine to the molecule CC(C)[C@@](C)(C#N)NC(=O)CN1CCCSc2ccccc21.,CC(C)[C@@](C)(C#N)NC(=O)CN1CCCSc2ccccc21,amine
192933,Please add a benzene ring to the molecule O=C(CCn1cnnn1)N1CCCN(c2ccccc2)CC1.,O=C(CCn1cnnn1)N1CCCN(c2ccccc2)CC1,benzene ring
176700,Please add a halo to the molecule C[C@H]1CCCC[NH+]1CC(=O)N1N=C(c2ccc(F)cc2)C[C@H]1c1ccccc1Cl.,C[C@H]1CCCC[NH+]1CC(=O)N1N=C(c2ccc(F)cc2)C[C@H]1c1ccccc1Cl,halo
34243,Add a nitro to the molecule Cc1ccc(C(=O)Nc2ccc(N3CCN(C(=O)c4ccco4)CC3)c(Cl)c2)c(C)c1.,Cc1ccc(C(=O)Nc2ccc(N3CCN(C(=O)c4ccco4)CC3)c(Cl)c2)c(C)c1,nitro
175288,Please add a benzene ring to the molecule CCOc1ccccc1NC(=O)/C(C#N)=C\c1ccc(F)c(C)c1.,CCOc1ccccc1NC(=O)/C(C#N)=C\c1ccc(F)c(C)c1,benzene ring
10636,Please add a aldehyde to the molecule COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccccc4Br)CC3)N=N2)cc1.,COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccccc4Br)CC3)N=N2)cc1,aldehyde
224724,Please add a carboxyl to the molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1.,CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,carboxyl
170318,Modify the molecule Cc1c(/C=N/N=C2\CC[C@@H]3[C@H]4CCc5cc(O)ccc5[C@@H]4CC[C@]23C)cnn1C by adding a aldehyde.,Cc1c(/C=N/N=C2\CC[C@@H]3[C@H]4CCc5cc(O)ccc5[C@@H]4CC[C@]23C)cnn1C,aldehyde
248586,Please add a amine to the molecule CCNC(=O)NC(=O)C[NH+](C)CCOc1ccccc1.,CCNC(=O)NC(=O)C[NH+](C)CCOc1ccccc1,amine
196170,Add a amide to the molecule CC(C)CC1(C(=O)N(C)[C@H](C)CC[NH3+])CCCC1.,CC(C)CC1(C(=O)N(C)[C@H](C)CC[NH3+])CCCC1,amide
228837,Please add a amide to the molecule C[C@@H]1CN(c2nc3ccc(F)cn3n2)CC[NH2+]1.,C[C@@H]1CN(c2nc3ccc(F)cn3n2)CC[NH2+]1,amide
148455,Please add a halo to the molecule COc1cc(C(N)=[NH2+])ccc1OCc1nc(C)c(C)s1.,COc1cc(C(N)=[NH2+])ccc1OCc1nc(C)c(C)s1,halo
211619,Modify the molecule C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O by adding a carboxyl.,C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O,carboxyl
116263,Modify the molecule N=C1NC(=O)/C(=C/c2cc(Cl)ccc2O)S1 by adding a carboxyl.,N=C1NC(=O)/C(=C/c2cc(Cl)ccc2O)S1,carboxyl
188091,Add a hydroxyl to the molecule CN1C(=O)NC(=O)[C@@]12CCC[NH2+]C2.,CN1C(=O)NC(=O)[C@@]12CCC[NH2+]C2,hydroxyl
12710,Add a benzene ring to the molecule C[C@@H](SCc1ccccc1)C(=O)Nc1ccc(OC2CC[NH+](C)CC2)cc1.,C[C@@H](SCc1ccccc1)C(=O)Nc1ccc(OC2CC[NH+](C)CC2)cc1,benzene ring
16849,Add a amide to the molecule CNc1cc(Br)cc(F)c1N.,CNc1cc(Br)cc(F)c1N,amide
221136,Add a hydroxyl to the molecule CCC(CC)(NC(=O)N(C)C1CC[NH2+]CC1)C(=O)[O-].,CCC(CC)(NC(=O)N(C)C1CC[NH2+]CC1)C(=O)[O-],hydroxyl
173424,Add a amine to the molecule C[C@@H](C(=O)[O-])N1C(=O)/C(=C/c2ccc(F)cc2)SC1=S.,C[C@@H](C(=O)[O-])N1C(=O)/C(=C/c2ccc(F)cc2)SC1=S,amine
76932,Please add a amide to the molecule Cc1cc(C[NH2+]Cc2cccnc2N2CC[NH+](C)CC2)ccc1F.,Cc1cc(C[NH2+]Cc2cccnc2N2CC[NH+](C)CC2)ccc1F,amide
37295,Add a amine to the molecule CCC[NH2+][C@@H](C)c1ccnc(N(C)[C@@H]2CCSC2)c1.,CCC[NH2+][C@@H](C)c1ccnc(N(C)[C@@H]2CCSC2)c1,amine
186309,Modify the molecule C[C@@H](Cn1nnnc1C1C(C)(C)C1(C)C)C(=O)[O-] by adding a amine.,C[C@@H](Cn1nnnc1C1C(C)(C)C1(C)C)C(=O)[O-],amine
92822,Add a carboxyl to the molecule Cc1ccc([C@@H]2CCCCCN2S(C)(=O)=O)cc1.,Cc1ccc([C@@H]2CCCCCN2S(C)(=O)=O)cc1,carboxyl
193211,Add a hydroxyl to the molecule CC[NH2+]Cc1ccccc1S(=O)(=O)NC1C(C)(C)C1(C)C.,CC[NH2+]Cc1ccccc1S(=O)(=O)NC1C(C)(C)C1(C)C,hydroxyl
52423,Please add a amide to the molecule O=[S@@](Cc1cc(Cl)c2c(c1)OCCO2)c1cccc(F)c1.,O=[S@@](Cc1cc(Cl)c2c(c1)OCCO2)c1cccc(F)c1,amide
42722,Modify the molecule CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21 by adding a nitro.,CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21,nitro
51118,Modify the molecule CCN(CC)c1ccc([C@H]2Nc3c(C(=O)N(C)C)cccc3[C@H]3C=CC[C@H]32)cc1 by adding a benzene ring.,CCN(CC)c1ccc([C@H]2Nc3c(C(=O)N(C)C)cccc3[C@H]3C=CC[C@H]32)cc1,benzene ring
197850,Modify the molecule N#Cc1cn(C2CC2)c(=O)n(Cc2ncc(-c3cccs3)o2)c1=O by adding a amide.,N#Cc1cn(C2CC2)c(=O)n(Cc2ncc(-c3cccs3)o2)c1=O,amide
168548,Modify the molecule C[C@@]([NH3+])(CCCSC1COC1)C(N)=O by adding a amide.,C[C@@]([NH3+])(CCCSC1COC1)C(N)=O,amide
34400,Add a benzene ring to the molecule Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12.,Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12,benzene ring
111568,Modify the molecule NC(=O)c1cccc(N2CC(n3cc(C(=O)[O-])nn3)C2)n1 by adding a halo.,NC(=O)c1cccc(N2CC(n3cc(C(=O)[O-])nn3)C2)n1,halo
244024,Add a amide to the molecule Fc1ccc(C(F)(F)F)cc1C[NH2+]C[C@@H]1CCCN(c2ncccn2)C1.,Fc1ccc(C(F)(F)F)cc1C[NH2+]C[C@@H]1CCCN(c2ncccn2)C1,amide
107761,Modify the molecule C[C@H](CCl)CS(=O)(=O)[N-]c1cccc(-n2ccnc2)c1 by adding a amine.,C[C@H](CCl)CS(=O)(=O)[N-]c1cccc(-n2ccnc2)c1,amine
64808,Add a hydroxyl to the molecule CC(=O)c1ccc(N2CCN(C(=O)[C@H]3CCCN(S(=O)(=O)c4cccc5nonc45)C3)CC2)cc1.,CC(=O)c1ccc(N2CCN(C(=O)[C@H]3CCCN(S(=O)(=O)c4cccc5nonc45)C3)CC2)cc1,hydroxyl
136346,Modify the molecule CC(=O)c1cccc(OCC(=O)Nc2nn(-c3ccccc3Cl)cc2C)c1 by adding a carboxyl.,CC(=O)c1cccc(OCC(=O)Nc2nn(-c3ccccc3Cl)cc2C)c1,carboxyl
139884,Please add a nitro to the molecule C[C@H](Nc1ccc(NC(=O)[C@H]2CCO[C@@H]2C)cc1Cl)c1ccccc1.,C[C@H](Nc1ccc(NC(=O)[C@H]2CCO[C@@H]2C)cc1Cl)c1ccccc1,nitro
82810,Modify the molecule O=C(N/N=C/c1ccc(N2CCOCC2)o1)c1cccc([N+](=O)[O-])c1 by adding a hydroxyl.,O=C(N/N=C/c1ccc(N2CCOCC2)o1)c1cccc([N+](=O)[O-])c1,hydroxyl
106706,Modify the molecule C[C@@H](Cc1cccs1)N(C)c1ncc(C(=O)[O-])s1 by adding a hydroxyl.,C[C@@H](Cc1cccs1)N(C)c1ncc(C(=O)[O-])s1,hydroxyl
93876,Add a carboxyl to the molecule CCCCN1CC(=O)N2[C@@H](c3cc(OC)c(OC)c(OC)c3)[C@@H]3[NH+]=c4ccccc4=C3C[C@@H]2C1=O.,CCCCN1CC(=O)N2[C@@H](c3cc(OC)c(OC)c(OC)c3)[C@@H]3[NH+]=c4ccccc4=C3C[C@@H]2C1=O,carboxyl
217883,Please add a hydroxyl to the molecule NS(=O)(=O)c1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)cc1.,NS(=O)(=O)c1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)cc1,hydroxyl
240079,Modify the molecule CCC[NH+]1CCCC[C@@H]1C(=O)N[C@@H](C)c1cccc(C#N)c1 by adding a aldehyde.,CCC[NH+]1CCCC[C@@H]1C(=O)N[C@@H](C)c1cccc(C#N)c1,aldehyde
82973,Please add a benzene ring to the molecule Cc1cc(C)cc(OC[C@@H]2N=[NH+]C(=S)N2NC(=O)Cc2ccccc2)c1.,Cc1cc(C)cc(OC[C@@H]2N=[NH+]C(=S)N2NC(=O)Cc2ccccc2)c1,benzene ring
146448,Modify the molecule CCC[NH+](C)C[C@@H]1CCN(Cc2c(C)nn(C)c2OC)C1 by adding a hydroxyl.,CCC[NH+](C)C[C@@H]1CCN(Cc2c(C)nn(C)c2OC)C1,hydroxyl
201489,Add a hydroxyl to the molecule CC(C)(C)CC(=O)N1CCC([NH2+]C[C@](C)(O)CN2CCOCC2)CC1.,CC(C)(C)CC(=O)N1CCC([NH2+]C[C@](C)(O)CN2CCOCC2)CC1,hydroxyl
69041,Modify the molecule COc1ccc(C(=O)Nc2nn(C(C)(C)C)cc2C#N)cc1-n1c(C)ccc1C by adding a amide.,COc1ccc(C(=O)Nc2nn(C(C)(C)C)cc2C#N)cc1-n1c(C)ccc1C,amide
135194,Add a carboxyl to the molecule CC(C)N(C)c1cccc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)c1.,CC(C)N(C)c1cccc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)c1,carboxyl
133460,Please add a halo to the molecule Cc1cccc(C)c1C(=O)NCC(C)(C)c1ccncc1.,Cc1cccc(C)c1C(=O)NCC(C)(C)c1ccncc1,halo
22932,Modify the molecule C[C@H](c1nc(=O)c2ccccc2[nH]1)[NH+]1CCN(c2ncccn2)CC1 by adding a hydroxyl.,C[C@H](c1nc(=O)c2ccccc2[nH]1)[NH+]1CCN(c2ncccn2)CC1,hydroxyl
136438,Please add a aldehyde to the molecule C[C@@H](CO)NC(=O)Nc1cccc(Br)c1.,C[C@@H](CO)NC(=O)Nc1cccc(Br)c1,aldehyde
134299,Add a amide to the molecule O=C(NCCC1=CCCCC1)[C@@H]1CCCC2=c3ccccc3=[NH+][C@H]21.,O=C(NCCC1=CCCCC1)[C@@H]1CCCC2=c3ccccc3=[NH+][C@H]21,amide
89295,Modify the molecule O=C(c1cccc(NCc2ncc(-c3ccccc3)o2)c1)N1CCOCC1 by adding a amide.,O=C(c1cccc(NCc2ncc(-c3ccccc3)o2)c1)N1CCOCC1,amide
16830,Please add a amine to the molecule CCOC(=O)N[C@@H]1CC2(CCCCC2)Oc2ccccc21.,CCOC(=O)N[C@@H]1CC2(CCCCC2)Oc2ccccc21,amine
82695,Modify the molecule Cc1ccccc1O[C@H](C)CNC(=O)NC[C@@H]1CCC[C@H](O)C1 by adding a hydroxyl.,Cc1ccccc1O[C@H](C)CNC(=O)NC[C@@H]1CCC[C@H](O)C1,hydroxyl
81035,Modify the molecule COc1cccc2ccc(C[NH+]3C[C@@H]4CC[C@@](O)(c5ccc(C)cn5)[C@H]4C3)nc12 by adding a amide.,COc1cccc2ccc(C[NH+]3C[C@@H]4CC[C@@](O)(c5ccc(C)cn5)[C@H]4C3)nc12,amide
220639,Modify the molecule CCc1cc(C(=O)N2CCO[C@@H](CC(=O)[O-])C2)sc1C by adding a amide.,CCc1cc(C(=O)N2CCO[C@@H](CC(=O)[O-])C2)sc1C,amide
77875,Add a aldehyde to the molecule COc1ccc(-c2csc3ncnc(NCc4ccccc4)c23)cc1.,COc1ccc(-c2csc3ncnc(NCc4ccccc4)c23)cc1,aldehyde
154032,Add a hydroxyl to the molecule CCCn1c(C)nn(CN2CCN(CC(F)(F)C(F)F)CC2)c1=S.,CCCn1c(C)nn(CN2CCN(CC(F)(F)C(F)F)CC2)c1=S,hydroxyl
9361,Modify the molecule CC[C@@H](C)NC(=O)Nc1ccccc1Br by adding a carboxyl.,CC[C@@H](C)NC(=O)Nc1ccccc1Br,carboxyl
88805,Modify the molecule Cc1cccc([C@@H](C)[S@](=O)Cc2cc(Cl)c3c(c2)OCCO3)c1 by adding a amide.,Cc1cccc([C@@H](C)[S@](=O)Cc2cc(Cl)c3c(c2)OCCO3)c1,amide
133396,Please add a hydroxyl to the molecule Cc1cc(NC(=O)[C@@H]2C[C@H]2c2ccccc2F)no1.,Cc1cc(NC(=O)[C@@H]2C[C@H]2c2ccccc2F)no1,hydroxyl
181421,Please add a benzene ring to the molecule CC1=C(C(=O)Nc2ccccc2)[C@H](c2c(C)cc(C)cc2C)NC(=O)N1.,CC1=C(C(=O)Nc2ccccc2)[C@H](c2c(C)cc(C)cc2C)NC(=O)N1,benzene ring
182092,Add a hydroxyl to the molecule C[C@H]([NH2+][C@@H]1CCCN(c2ccc(C#N)cc2F)C1)c1cccnc1.,C[C@H]([NH2+][C@@H]1CCCN(c2ccc(C#N)cc2F)C1)c1cccnc1,hydroxyl
140448,Add a carboxyl to the molecule COC(=O)[C@H](C)Sc1nnc(-c2ccco2)n1-c1cccc(Cl)c1.,COC(=O)[C@H](C)Sc1nnc(-c2ccco2)n1-c1cccc(Cl)c1,carboxyl
222280,Please add a benzene ring to the molecule CNC(=O)[C@H](C)CN(C)C(=O)CNC(=O)c1ccccc1C.,CNC(=O)[C@H](C)CN(C)C(=O)CNC(=O)c1ccccc1C,benzene ring
101628,Modify the molecule COC(C[C@@](C)(O)C[C@@H]1CCCN(S(C)(=O)=O)C1)OC by adding a amide.,COC(C[C@@](C)(O)C[C@@H]1CCCN(S(C)(=O)=O)C1)OC,amide
172996,Add a amide to the molecule COc1ccc(Br)c(C(=O)NCCc2ccc(C(F)(F)F)cc2)c1.,COc1ccc(Br)c(C(=O)NCCc2ccc(C(F)(F)F)cc2)c1,amide
47301,Please add a carboxyl to the molecule Cc1cc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)ccc1C(N)=O.,Cc1cc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)ccc1C(N)=O,carboxyl
67338,Modify the molecule CCN([C@@H](C)C(=O)Nc1ccc(C)cc1)S(=O)(=O)c1ccccc1Cl by adding a nitro.,CCN([C@@H](C)C(=O)Nc1ccc(C)cc1)S(=O)(=O)c1ccccc1Cl,nitro
33837,Please add a hydroxyl to the molecule Cc1cc(C(=O)N2CCN(Cc3ccccn3)CC2)c2c(=O)[nH]n(C)c2n1.,Cc1cc(C(=O)N2CCN(Cc3ccccn3)CC2)c2c(=O)[nH]n(C)c2n1,hydroxyl
32995,Add a hydroxyl to the molecule C[C@H]1C[C@H](NC(=O)COc2ccccc2C#N)CN1c1ccccc1.,C[C@H]1C[C@H](NC(=O)COc2ccccc2C#N)CN1c1ccccc1,hydroxyl
184388,Modify the molecule Cc1ccc(C(=O)N(CC2CC2)C(C)C)c(NN)c1 by adding a carboxyl.,Cc1ccc(C(=O)N(CC2CC2)C(C)C)c(NN)c1,carboxyl
59741,Please add a benzene ring to the molecule NNc1ncc(Br)cc1C(F)(F)F.,NNc1ncc(Br)cc1C(F)(F)F,benzene ring
223922,Add a carboxyl to the molecule COc1ccccc1-n1c(-c2ccc(F)cc2)coc1=O.,COc1ccccc1-n1c(-c2ccc(F)cc2)coc1=O,carboxyl
190963,Add a halo to the molecule Cc1cc(C)cc(Oc2ccc(NC(=O)N(C)CCC#N)cc2)c1.,Cc1cc(C)cc(Oc2ccc(NC(=O)N(C)CCC#N)cc2)c1,halo
110500,Modify the molecule O=C(NCCc1c[nH]c2ccccc12)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1 by adding a nitro.,O=C(NCCc1c[nH]c2ccccc12)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1,nitro
96348,Please add a benzene ring to the molecule O=C1OC(c2ccc3c(c2)OCO3)=N/C1=C\c1cccc(NC(=O)C(F)(F)F)c1.,O=C1OC(c2ccc3c(c2)OCO3)=N/C1=C\c1cccc(NC(=O)C(F)(F)F)c1,benzene ring
188441,Modify the molecule O=C(C[NH+]1CC[C@H](c2cc[nH]n2)C1)N1CCCC1 by adding a carboxyl.,O=C(C[NH+]1CC[C@H](c2cc[nH]n2)C1)N1CCCC1,carboxyl
154342,Modify the molecule NC(=O)c1ccsc1NC(=O)CN1C(=O)N[C@]2(CCOc3ccccc32)C1=O by adding a aldehyde.,NC(=O)c1ccsc1NC(=O)CN1C(=O)N[C@]2(CCOc3ccccc32)C1=O,aldehyde
25058,Please add a benzene ring to the molecule CNC(=O)Cc1ccc(NC(=O)C(=O)NCc2ccc(C)cc2)cc1.,CNC(=O)Cc1ccc(NC(=O)C(=O)NCc2ccc(C)cc2)cc1,benzene ring
31562,Modify the molecule CNc1nc(CNc2cc(C)[nH+]c3ccc(F)cc23)cs1 by adding a hydroxyl.,CNc1nc(CNc2cc(C)[nH+]c3ccc(F)cc23)cs1,hydroxyl
114773,Please add a benzene ring to the molecule C[C@@H]1CCCC[NH+]1CCNC(=O)c1nnc(C(=O)Nc2ccc(F)cc2)s1.,C[C@@H]1CCCC[NH+]1CCNC(=O)c1nnc(C(=O)Nc2ccc(F)cc2)s1,benzene ring
104842,Please add a hydroxyl to the molecule COc1cccc(C(=O)N[C@H](C)c2nc3ccccc3n2Cc2ccccc2)c1.,COc1cccc(C(=O)N[C@H](C)c2nc3ccccc3n2Cc2ccccc2)c1,hydroxyl
230230,Add a carboxyl to the molecule C[C@@H]1CCCN(C(=O)CCCNc2ccc([N+](=O)[O-])cc2)CC1.,C[C@@H]1CCCN(C(=O)CCCNc2ccc([N+](=O)[O-])cc2)CC1,carboxyl
131697,Please add a benzene ring to the molecule Cc1ccc(F)c(NC(=O)CCCNS(=O)(=O)c2ccc3c(c2)OCCO3)c1.,Cc1ccc(F)c(NC(=O)CCCNS(=O)(=O)c2ccc3c(c2)OCCO3)c1,benzene ring
168717,Modify the molecule O=C(Nc1cccc(NC2CCCC2)c1)c1ncncc1Cl by adding a amine.,O=C(Nc1cccc(NC2CCCC2)c1)c1ncncc1Cl,amine
112880,Please add a benzene ring to the molecule O=S(=O)([O-])c1cccc(/N=N\c2ccc3c(O)cccc3c2O)c1.,O=S(=O)([O-])c1cccc(/N=N\c2ccc3c(O)cccc3c2O)c1,benzene ring
171768,Modify the molecule Cc1cccc(Cn2nccc2NC(=O)COc2ccc(Br)cc2C=O)c1 by adding a benzene ring.,Cc1cccc(Cn2nccc2NC(=O)COc2ccc(Br)cc2C=O)c1,benzene ring
223135,Add a amide to the molecule CCOC(=O)c1cncc(-c2sccc2C(=O)[O-])c1.,CCOC(=O)c1cncc(-c2sccc2C(=O)[O-])c1,amide
85631,Add a hydroxyl to the molecule O=C([C@H]1SCCc2ccccc21)N1CCSc2ncccc21.,O=C([C@H]1SCCc2ccccc21)N1CCSc2ncccc21,hydroxyl
183250,Modify the molecule O=C([O-])c1cc(N2CC[NH2+]CC2)[nH+]c2ccccc12 by adding a hydroxyl.,O=C([O-])c1cc(N2CC[NH2+]CC2)[nH+]c2ccccc12,hydroxyl
195938,Add a hydroxyl to the molecule O=C1C[C@@H](C(=O)N2CC[C@@H](Nc3ccccc3)C2)CN1CC1CC1.,O=C1C[C@@H](C(=O)N2CC[C@@H](Nc3ccccc3)C2)CN1CC1CC1,hydroxyl
50999,Modify the molecule CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)C(C)(C)C by adding a thiol.,CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)C(C)(C)C,thiol
160833,Please add a carboxyl to the molecule COc1cc(OC)c(NC(=O)[C@@H]2CS[C@]3(c4cccs4)CCC(=O)N23)cc1Cl.,COc1cc(OC)c(NC(=O)[C@@H]2CS[C@]3(c4cccs4)CCC(=O)N23)cc1Cl,carboxyl
87066,Add a amide to the molecule COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1.,COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1,amide
179345,Please add a benzene ring to the molecule CC(C)N(C[C@H](C)O)C(=O)Nc1cccc(-c2ncon2)c1.,CC(C)N(C[C@H](C)O)C(=O)Nc1cccc(-c2ncon2)c1,benzene ring
57970,Modify the molecule C[C@@H](CNC(=O)NCc1cccc(C[NH+](C)C)c1)[NH+]1CCc2ccccc2C1 by adding a amide.,C[C@@H](CNC(=O)NCc1cccc(C[NH+](C)C)c1)[NH+]1CCc2ccccc2C1,amide
12284,Please add a amide to the molecule COc1ccc(NC(=O)Cn2nnc(C(=O)Nc3cccc(C)c3C)c2C)c(OC)c1.,COc1ccc(NC(=O)Cn2nnc(C(=O)Nc3cccc(C)c3C)c2C)c(OC)c1,amide
202553,Add a hydroxyl to the molecule CO[C@@]1(C)C[C@H](OC(=O)c2cnc3c(C)cccn3c2=O)C1(C)C.,CO[C@@]1(C)C[C@H](OC(=O)c2cnc3c(C)cccn3c2=O)C1(C)C,hydroxyl
74576,Please add a benzene ring to the molecule CCc1nc(CNC(=O)NCC2(Sc3ccccc3)CC2)cs1.,CCc1nc(CNC(=O)NCC2(Sc3ccccc3)CC2)cs1,benzene ring
70585,Add a hydroxyl to the molecule CNc1oc(-c2ccccc2Cl)nc1S(=O)(=O)c1ccc(F)cc1.,CNc1oc(-c2ccccc2Cl)nc1S(=O)(=O)c1ccc(F)cc1,hydroxyl
128378,Modify the molecule C[C@H]1CCC[C@@](C[NH3+])(N(C)CCS(C)(=O)=O)CC1 by adding a carboxyl.,C[C@H]1CCC[C@@](C[NH3+])(N(C)CCS(C)(=O)=O)CC1,carboxyl
91216,Modify the molecule COC(=O)[C@@H]1C[C@@H](C(=O)[O-])[C@@H](c2cccc(F)c2F)[NH+]1C by adding a benzene ring.,COC(=O)[C@@H]1C[C@@H](C(=O)[O-])[C@@H](c2cccc(F)c2F)[NH+]1C,benzene ring
200670,Add a amide to the molecule Cc1[nH]c2ccccc2c1CC(=O)N(Cc1cccnc1)C[C@@H]1CCCO1.,Cc1[nH]c2ccccc2c1CC(=O)N(Cc1cccnc1)C[C@@H]1CCCO1,amide
65571,Please add a nitro to the molecule CCn1cc(CN2CCO[C@@H](c3cc(F)c(Cl)cc3Cl)C2)cn1.,CCn1cc(CN2CCO[C@@H](c3cc(F)c(Cl)cc3Cl)C2)cn1,nitro
219819,Modify the molecule CNC(=O)Cc1ccc(NC(=O)c2sc(C3CCCC3)nc2C)cc1 by adding a amide.,CNC(=O)Cc1ccc(NC(=O)c2sc(C3CCCC3)nc2C)cc1,amide
238196,Add a amine to the molecule Cc1cc(=O)[nH]c(SCCOc2cccc(C(F)(F)F)c2)n1.,Cc1cc(=O)[nH]c(SCCOc2cccc(C(F)(F)F)c2)n1,amine
218613,Please add a carboxyl to the molecule Cc1cnc2c(c1)[nH]c(=S)n2[C@H](C)Cc1ccc(C)s1.,Cc1cnc2c(c1)[nH]c(=S)n2[C@H](C)Cc1ccc(C)s1,carboxyl
176159,Add a hydroxyl to the molecule CCOc1ccc(C2=NC(=O)[C@H]3SC(=S)N(C)C3=N2)cc1OCC.,CCOc1ccc(C2=NC(=O)[C@H]3SC(=S)N(C)C3=N2)cc1OCC,hydroxyl
69250,Please add a hydroxyl to the molecule Cn1ccc(NC(=O)N2CCC(c3ccc(F)cc3)CC2)n1.,Cn1ccc(NC(=O)N2CCC(c3ccc(F)cc3)CC2)n1,hydroxyl
233141,Please add a halo to the molecule O=C([C@@H]1CN(C(=O)Cc2cccs2)c2ccccc2O1)N1CCCCC1.,O=C([C@@H]1CN(C(=O)Cc2cccs2)c2ccccc2O1)N1CCCCC1,halo
177894,Please add a benzene ring to the molecule COc1cccc(NC(=O)c2ccc(C)c(NC(=O)c3ccccc3)c2)c1.,COc1cccc(NC(=O)c2ccc(C)c(NC(=O)c3ccccc3)c2)c1,benzene ring
83833,Add a amine to the molecule Cc1nc2ccc(C(=O)N(C3CC3)[C@@H]3CC([O-])=NC3=O)cc2nc1C.,Cc1nc2ccc(C(=O)N(C3CC3)[C@@H]3CC([O-])=NC3=O)cc2nc1C,amine
129431,Add a amine to the molecule CNc1cc[nH+]c(N(C)Cc2ccc(C[NH+](C)C)cc2)n1.,CNc1cc[nH+]c(N(C)Cc2ccc(C[NH+](C)C)cc2)n1,amine
36262,Modify the molecule CCN(C(=O)CNC(=O)NC1CCCCC1)c1cc(C)ccc1C by adding a halo.,CCN(C(=O)CNC(=O)NC1CCCCC1)c1cc(C)ccc1C,halo
32329,Add a benzene ring to the molecule COc1cc(OC)c(-c2cnc(CNN(C)C)s2)cc1OC.,COc1cc(OC)c(-c2cnc(CNN(C)C)s2)cc1OC,benzene ring
141741,Modify the molecule C[C@@]12CCC[C@@H]3C(=O)C(Cl)(Cl)C(=O)N(c4ccccc41)[C@@H]32 by adding a hydroxyl.,C[C@@]12CCC[C@@H]3C(=O)C(Cl)(Cl)C(=O)N(c4ccccc41)[C@@H]32,hydroxyl
227859,Add a halo to the molecule C[C@@H](C(=O)c1ccccc1)[C@]1(O)C(=O)Nc2ccc(Cl)cc21.,C[C@@H](C(=O)c1ccccc1)[C@]1(O)C(=O)Nc2ccc(Cl)cc21,halo
184142,Modify the molecule CCNC(=S)NN=C1CCC(C(C)(C)C)CC1 by adding a carboxyl.,CCNC(=S)NN=C1CCC(C(C)(C)C)CC1,carboxyl
117541,Please add a benzene ring to the molecule CN(CCOCC1CC1)C(=O)C1(c2ccccc2)CCC1.,CN(CCOCC1CC1)C(=O)C1(c2ccccc2)CCC1,benzene ring
32515,Add a nitro to the molecule COC(=O)Cc1c(C)c2c(O)cc(O)cc2oc1=O.,COC(=O)Cc1c(C)c2c(O)cc(O)cc2oc1=O,nitro
75370,Modify the molecule CCOC(=O)[C@]1([NH2+]C(C)C)CC[C@@H](n2cc[nH+]c2C)C1 by adding a hydroxyl.,CCOC(=O)[C@]1([NH2+]C(C)C)CC[C@@H](n2cc[nH+]c2C)C1,hydroxyl
73455,Please add a benzene ring to the molecule COc1ccc(N2CCN(c3ncnc4c5cc(OC)ccc5n(C)c34)C[C@H]2C)cc1.,COc1ccc(N2CCN(c3ncnc4c5cc(OC)ccc5n(C)c34)C[C@H]2C)cc1,benzene ring
148012,Add a halo to the molecule CC(C)(C)C[C@@](C)(O)C(C)(C)C.,CC(C)(C)C[C@@](C)(O)C(C)(C)C,halo
45497,Please add a carboxyl to the molecule CC[NH+](CC)c1ccc(CN2CCS(=O)(=O)[C@H](C)[C@@H]2C)cc1.,CC[NH+](CC)c1ccc(CN2CCS(=O)(=O)[C@H](C)[C@@H]2C)cc1,carboxyl
35552,Add a thiol to the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)C[C@H]2OCCc3ccsc32)C1.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)C[C@H]2OCCc3ccsc32)C1,thiol
202495,Add a nitro to the molecule CCOc1ccccc1NC(=O)Nc1nnc(Cc2ccccc2)o1.,CCOc1ccccc1NC(=O)Nc1nnc(Cc2ccccc2)o1,nitro
234899,Please add a benzene ring to the molecule CN1C[C@H](c2cc(=O)n3nc(-c4cccc(Cl)c4)cc3[nH]2)CC1=O.,CN1C[C@H](c2cc(=O)n3nc(-c4cccc(Cl)c4)cc3[nH]2)CC1=O,benzene ring
217294,Add a aldehyde to the molecule CCn1nc(COc2ccc(C=O)nc2)c2ccccc21.,CCn1nc(COc2ccc(C=O)nc2)c2ccccc21,aldehyde
33413,Modify the molecule CC1CCC(C[NH3+])([C@@](C)(O)c2ccc(F)cc2)CC1 by adding a hydroxyl.,CC1CCC(C[NH3+])([C@@](C)(O)c2ccc(F)cc2)CC1,hydroxyl
218758,Add a benzene ring to the molecule Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1.,Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1,benzene ring
29628,Modify the molecule COc1cc(C[NH+]2CCC[C@@H](C(=O)NN)C2)ccc1OC(C)C by adding a hydroxyl.,COc1cc(C[NH+]2CCC[C@@H](C(=O)NN)C2)ccc1OC(C)C,hydroxyl
164782,Modify the molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)N[C@H](c3cccc(F)c3)c3nccn3C)ccc21 by adding a halo.,CCn1c(=O)c(=O)[nH]c2cc(C(=O)N[C@H](c3cccc(F)c3)c3nccn3C)ccc21,halo
106404,Modify the molecule COc1ccc(NC(C)=O)cc1NC(=O)[C@@H](C)N1CCc2cc(C)ccc21 by adding a hydroxyl.,COc1ccc(NC(C)=O)cc1NC(=O)[C@@H](C)N1CCc2cc(C)ccc21,hydroxyl
241831,Please add a hydroxyl to the molecule Cc1cc2cc3c(cc2n2c(SCC(=O)Nc4nc(C(C)(C)C)cs4)nnc12)OCCO3.,Cc1cc2cc3c(cc2n2c(SCC(=O)Nc4nc(C(C)(C)C)cs4)nnc12)OCCO3,hydroxyl
136392,Modify the molecule C[C@H](C(=O)N1CCOCC1)N1CCN(CC(=O)Nc2cc(F)cc(F)c2)CC1 by adding a nitro.,C[C@H](C(=O)N1CCOCC1)N1CCN(CC(=O)Nc2cc(F)cc(F)c2)CC1,nitro
127234,Modify the molecule FC(F)(F)c1ccc2c(n1)CCN(Cc1ccccc1)C2 by adding a hydroxyl.,FC(F)(F)c1ccc2c(n1)CCN(Cc1ccccc1)C2,hydroxyl
172201,Modify the molecule COCCNc1ccc(C#N)c([N+](=O)[O-])c1 by adding a hydroxyl.,COCCNc1ccc(C#N)c([N+](=O)[O-])c1,hydroxyl
56991,Add a amine to the molecule O=C(c1ccccc1I)N1CCC[C@H]2CCCC[C@@H]21.,O=C(c1ccccc1I)N1CCC[C@H]2CCCC[C@@H]21,amine
37865,Please add a benzene ring to the molecule CCCc1cc(NC(=O)[C@H](C)CCC)n(C)n1.,CCCc1cc(NC(=O)[C@H](C)CCC)n(C)n1,benzene ring
148541,Modify the molecule COC(=O)c1ccc(C(=O)NC[C@H](C)Oc2ccccc2C)s1 by adding a hydroxyl.,COC(=O)c1ccc(C(=O)NC[C@H](C)Oc2ccccc2C)s1,hydroxyl
187292,Modify the molecule C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3 by adding a benzene ring.,C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3,benzene ring
188102,Please add a nitro to the molecule CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1.,CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1,nitro
236067,Add a amide to the molecule CC[NH+]1CCC[C@@H]1CNC(=O)c1ccc(N2CCCCCC2)nc1.,CC[NH+]1CCC[C@@H]1CNC(=O)c1ccc(N2CCCCCC2)nc1,amide
196350,Please add a aldehyde to the molecule c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1.,c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1,aldehyde
224255,Modify the molecule COc1ccc2nc(C(=O)NCC[C@H](O)c3ccccc3)ccc2c1 by adding a benzene ring.,COc1ccc2nc(C(=O)NCC[C@H](O)c3ccccc3)ccc2c1,benzene ring
58744,Modify the molecule CCC(=O)N1CCN(Cc2nc3cc(NC(=O)c4ccc([N+](=O)[O-])cc4)ccc3n2CC)CC1 by adding a amide.,CCC(=O)N1CCN(Cc2nc3cc(NC(=O)c4ccc([N+](=O)[O-])cc4)ccc3n2CC)CC1,amide
133027,Please add a amide to the molecule CC(C)CSCCC[NH+](C)[C@@H]1CCSC1.,CC(C)CSCCC[NH+](C)[C@@H]1CCSC1,amide
213656,Add a benzene ring to the molecule Cc1nn(-c2ccc(F)cc2)c(C)c1C(=O)NC[C@@H](CC(C)C)[NH+](C)C.,Cc1nn(-c2ccc(F)cc2)c(C)c1C(=O)NC[C@@H](CC(C)C)[NH+](C)C,benzene ring
238606,Modify the molecule CC(C)c1ccc(OCC(=O)Nc2c(F)cc(F)cc2F)cc1 by adding a benzene ring.,CC(C)c1ccc(OCC(=O)Nc2c(F)cc(F)cc2F)cc1,benzene ring
212961,Add a hydroxyl to the molecule Cc1c(C#N)c(NC(=O)CSc2nccn2C)n(C2CCCC2)c1C.,Cc1c(C#N)c(NC(=O)CSc2nccn2C)n(C2CCCC2)c1C,hydroxyl
98713,Please add a aldehyde to the molecule C[C@H]1C[C@@H]([NH3+])CN(c2[nH+]c3ccccc3n2C)C1.,C[C@H]1C[C@@H]([NH3+])CN(c2[nH+]c3ccccc3n2C)C1,aldehyde
32272,Add a nitrile to the molecule Cc1nn(C)c(Cl)c1S(=O)(=O)N1[C@H]2CC[C@@H]1c1cnc(N3CCOCC3)nc1C2.,Cc1nn(C)c(Cl)c1S(=O)(=O)N1[C@H]2CC[C@@H]1c1cnc(N3CCOCC3)nc1C2,nitrile
234534,Add a amine to the molecule O=C([O-])[C@H]1CCC(=O)N(CCc2ccccc2F)[C@@H]1c1cccs1.,O=C([O-])[C@H]1CCC(=O)N(CCc2ccccc2F)[C@@H]1c1cccs1,amine
114232,Add a benzene ring to the molecule Cc1cc(C#N)ccc1S(=O)(=O)NCCc1cn2cccc(C)c2n1.,Cc1cc(C#N)ccc1S(=O)(=O)NCCc1cn2cccc(C)c2n1,benzene ring
205952,Modify the molecule Cc1csc(CN2CC[C@@H](C[NH+]3CCCCC3)C2)n1 by adding a benzene ring.,Cc1csc(CN2CC[C@@H](C[NH+]3CCCCC3)C2)n1,benzene ring
99165,Please add a benzene ring to the molecule CNC(=O)CN(C)C(=O)c1ccc(C#N)c(C)n1.,CNC(=O)CN(C)C(=O)c1ccc(C#N)c(C)n1,benzene ring
113797,Please add a aldehyde to the molecule C[C@@H](C(=O)NCc1ccc(F)cc1)[S@@](=O)Cc1ccc(F)cc1.,C[C@@H](C(=O)NCc1ccc(F)cc1)[S@@](=O)Cc1ccc(F)cc1,aldehyde
196182,Please add a amide to the molecule C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1.,C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1,amide
139640,Add a aldehyde to the molecule O=C(COc1ccc(Br)cc1)N1CCOC[C@@H]1C1CC1.,O=C(COc1ccc(Br)cc1)N1CCOC[C@@H]1C1CC1,aldehyde
54520,Add a hydroxyl to the molecule CC[C@@]1(c2ccc(Cl)cc2)NC(=O)N(CN(C)Cc2c(C)noc2C)C1=O.,CC[C@@]1(c2ccc(Cl)cc2)NC(=O)N(CN(C)Cc2c(C)noc2C)C1=O,hydroxyl
131969,Modify the molecule C=CCO[C@H](F)C(=O)OCC by adding a hydroxyl.,C=CCO[C@H](F)C(=O)OCC,hydroxyl
122625,Please add a nitrile to the molecule O=C(Nc1cccnc1Cl)c1cc2ccccc2s1.,O=C(Nc1cccnc1Cl)c1cc2ccccc2s1,nitrile
28079,Please add a aldehyde to the molecule Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCC[C@H](C)C2)n1.,Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCC[C@H](C)C2)n1,aldehyde
224491,Add a hydroxyl to the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NCC1(O)CCCCC1.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NCC1(O)CCCCC1,hydroxyl
49868,Please add a aldehyde to the molecule Fc1cccc(C/[NH+]=C2\NC[C@@H](c3ccccc3)S2)c1.,Fc1cccc(C/[NH+]=C2\NC[C@@H](c3ccccc3)S2)c1,aldehyde
236801,Modify the molecule C=CCC[C@@H](NC(=O)C=C1CCSCC1)c1ccccc1 by adding a nitro.,C=CCC[C@@H](NC(=O)C=C1CCSCC1)c1ccccc1,nitro
77163,Modify the molecule CCc1c(C(=O)NCC(=O)[O-])nnn1-c1ccc(Cl)cc1 by adding a amine.,CCc1c(C(=O)NCC(=O)[O-])nnn1-c1ccc(Cl)cc1,amine
236201,Add a hydroxyl to the molecule O=[N+]([O-])c1cccc(Cn2nnc(-c3ccccc3)n2)c1.,O=[N+]([O-])c1cccc(Cn2nnc(-c3ccccc3)n2)c1,hydroxyl
131017,Please add a hydroxyl to the molecule CCc1nc2sc([C@H](c3cccc(OC)c3)N3CC[NH+](Cc4ccccc4)CC3)c(O)n2n1.,CCc1nc2sc([C@H](c3cccc(OC)c3)N3CC[NH+](Cc4ccccc4)CC3)c(O)n2n1,hydroxyl
225868,Modify the molecule COc1ccc(OC)c(-c2csc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)n2)c1 by adding a hydroxyl.,COc1ccc(OC)c(-c2csc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)n2)c1,hydroxyl
70569,Add a nitro to the molecule CCCOc1ccc(CNC(=O)c2cn(C)nc2CC)cc1.,CCCOc1ccc(CNC(=O)c2cn(C)nc2CC)cc1,nitro
181707,Modify the molecule CC(C)n1cc(NC(=O)N[C@H](C)C(=O)NCc2ccco2)cn1 by adding a thiol.,CC(C)n1cc(NC(=O)N[C@H](C)C(=O)NCc2ccco2)cn1,thiol
198781,Modify the molecule Cc1cccc(C=O)c1OS(=O)(=O)c1ccc(Cl)cc1C#N by adding a nitro.,Cc1cccc(C=O)c1OS(=O)(=O)c1ccc(Cl)cc1C#N,nitro
27550,Modify the molecule CC[C@H]1CCCN(C(=O)/C=C/c2ccc(NC(C)=O)cc2)C1 by adding a carboxyl.,CC[C@H]1CCCN(C(=O)/C=C/c2ccc(NC(C)=O)cc2)C1,carboxyl
215161,Add a hydroxyl to the molecule C[C@@H](O)CC(=O)N/N=C1\C(=O)N(CC[NH+]2CCCCC2)c2ccccc21.,C[C@@H](O)CC(=O)N/N=C1\C(=O)N(CC[NH+]2CCCCC2)c2ccccc21,hydroxyl
55322,Modify the molecule CCC(=O)Nc1ccc(N[C@@H](C)C(=O)Nc2c(C)cccc2CC)cc1 by adding a hydroxyl.,CCC(=O)Nc1ccc(N[C@@H](C)C(=O)Nc2c(C)cccc2CC)cc1,hydroxyl
156353,Add a nitro to the molecule Cc1ccc2cccc(NC(=O)c3ccc(-c4cccc([N+](=O)[O-])c4)o3)c2n1.,Cc1ccc2cccc(NC(=O)c3ccc(-c4cccc([N+](=O)[O-])c4)o3)c2n1,nitro
222765,Modify the molecule O=C(Nc1ccc2[nH]ncc2c1)c1ccc([N+](=O)[O-])cc1F by adding a hydroxyl.,O=C(Nc1ccc2[nH]ncc2c1)c1ccc([N+](=O)[O-])cc1F,hydroxyl
2849,Modify the molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 by adding a hydroxyl.,CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21,hydroxyl
42182,Add a benzene ring to the molecule C[C@@H]1C[C@H]([NH2+]CCOc2ccccc2)CS1.,C[C@@H]1C[C@H]([NH2+]CCOc2ccccc2)CS1,benzene ring
200860,Modify the molecule Cc1ccc(Br)cc1[C@H]([NH3+])c1ccc(Br)o1 by adding a aldehyde.,Cc1ccc(Br)cc1[C@H]([NH3+])c1ccc(Br)o1,aldehyde
68558,Add a hydroxyl to the molecule CC(=O)N1CCc2cc(S(=O)(=O)Nc3cc(C)cc(C)c3)ccc21.,CC(=O)N1CCc2cc(S(=O)(=O)Nc3cc(C)cc(C)c3)ccc21,hydroxyl
229074,Add a amine to the molecule C[C@H]1CN(c2ccc(N[C@H](C(N)=O)c3ccccc3)cc2F)C[C@@H](C)O1.,C[C@H]1CN(c2ccc(N[C@H](C(N)=O)c3ccccc3)cc2F)C[C@@H](C)O1,amine
93924,Modify the molecule C[NH+]1CCN(C(=O)Nc2cccc3ccccc23)[C@@H](c2ccccc2)C1 by adding a nitrile.,C[NH+]1CCN(C(=O)Nc2cccc3ccccc23)[C@@H](c2ccccc2)C1,nitrile
166503,Please add a halo to the molecule Cc1cccc(C)c1-n1c(=S)[nH]c2sc3c(c2c1=O)CCN(Cc1ccccc1)C3.,Cc1cccc(C)c1-n1c(=S)[nH]c2sc3c(c2c1=O)CCN(Cc1ccccc1)C3,halo
32179,Add a aldehyde to the molecule CCC[NH+](CCC(C)C)CC1CC[NH2+]CC1.,CCC[NH+](CCC(C)C)CC1CC[NH2+]CC1,aldehyde
43695,Please add a hydroxyl to the molecule COc1ccc(N[C@@H](C)[C@H](C)O)cc1Cl.,COc1ccc(N[C@@H](C)[C@H](C)O)cc1Cl,hydroxyl
39647,Modify the molecule O=C(CN1CCN(Cc2ccccn2)CC1)Nc1nc(-c2ccco2)cs1 by adding a nitro.,O=C(CN1CCN(Cc2ccccn2)CC1)Nc1nc(-c2ccco2)cs1,nitro
118871,Modify the molecule CN(Cc1ccc(Br)cc1)C(=O)[C@@H](O)c1ccccc1 by adding a benzene ring.,CN(Cc1ccc(Br)cc1)C(=O)[C@@H](O)c1ccccc1,benzene ring
248148,Please add a benzene ring to the molecule C=CCC[C@H](C)OC(=O)/C=C/c1ccco1.,C=CCC[C@H](C)OC(=O)/C=C/c1ccco1,benzene ring
84398,Add a hydroxyl to the molecule COc1ccc(C(=O)N(C)Cc2cc(C)on2)cc1.,COc1ccc(C(=O)N(C)Cc2cc(C)on2)cc1,hydroxyl
166945,Please add a halo to the molecule COc1ccc(CCNC(=O)Cn2nc(-c3ccc(C)c(C)c3)ccc2=O)cc1.,COc1ccc(CCNC(=O)Cn2nc(-c3ccc(C)c(C)c3)ccc2=O)cc1,halo
104559,Modify the molecule C[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)CC[NH+]1Cc1cncs1 by adding a aldehyde.,C[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)CC[NH+]1Cc1cncs1,aldehyde
242930,Add a hydroxyl to the molecule Cc1nn(C(F)F)c(C)c1CC(=O)N[C@@H](Cc1ccccc1)C1CC1.,Cc1nn(C(F)F)c(C)c1CC(=O)N[C@@H](Cc1ccccc1)C1CC1,hydroxyl
162484,Please add a hydroxyl to the molecule COC[C@@H](O)CN(C)C(=O)c1cc(C)n(-c2ccc(OC)cc2)n1.,COC[C@@H](O)CN(C)C(=O)c1cc(C)n(-c2ccc(OC)cc2)n1,hydroxyl
93078,Add a nitro to the molecule CCOc1ccccc1[C@@H]1C[C@@H]1[C@@H](C)O.,CCOc1ccccc1[C@@H]1C[C@@H]1[C@@H](C)O,nitro
1186,Modify the molecule Cc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)N(C)Cc2cccc(Cl)c2)cc1 by adding a nitro.,Cc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)N(C)Cc2cccc(Cl)c2)cc1,nitro
60286,Add a halo to the molecule C[NH2+][C@H](CN1CCOCC1=O)c1ccc(C)c(C)c1.,C[NH2+][C@H](CN1CCOCC1=O)c1ccc(C)c(C)c1,halo
11940,Modify the molecule N#CCCN1CCN(c2ccc(NS(=O)(=O)c3ccccc3Cl)cc2C(=O)[O-])CC1 by adding a amide.,N#CCCN1CCN(c2ccc(NS(=O)(=O)c3ccccc3Cl)cc2C(=O)[O-])CC1,amide
102096,Please add a nitro to the molecule CC[C@H](C)Sc1ccc(NC(=O)N(C)CC[NH+](C)C)c(C)c1.,CC[C@H](C)Sc1ccc(NC(=O)N(C)CC[NH+](C)C)c(C)c1,nitro
200823,Please add a amide to the molecule CCCCCN(C)C(=O)[C@@](C)(N)C(F)(F)F.,CCCCCN(C)C(=O)[C@@](C)(N)C(F)(F)F,amide
171536,Modify the molecule O=C1CCC(=O)N1C(=O)C(F)(F)F by adding a amide.,O=C1CCC(=O)N1C(=O)C(F)(F)F,amide
60259,Add a thiol to the molecule C[C@H](NC(=O)C(=O)Nc1ccc(N(C)C)cc1)c1ccccc1Cl.,C[C@H](NC(=O)C(=O)Nc1ccc(N(C)C)cc1)c1ccccc1Cl,thiol
248484,Please add a benzene ring to the molecule COc1ccc(C(=O)C2=C([O-])C(=O)N(C[C@@H]3CCCO3)[C@H]2c2sccc2C)cc1.,COc1ccc(C(=O)C2=C([O-])C(=O)N(C[C@@H]3CCCO3)[C@H]2c2sccc2C)cc1,benzene ring
139530,Add a amine to the molecule C[C@@]1(c2ccccc2)NC(=O)N(CC(=O)Nc2ccc(Cl)cc2)C1=O.,C[C@@]1(c2ccccc2)NC(=O)N(CC(=O)Nc2ccc(Cl)cc2)C1=O,amine
204942,Modify the molecule Cc1cc(CN(C)C(=O)c2cn(C)nc2C(C)(C)C)no1 by adding a nitro.,Cc1cc(CN(C)C(=O)c2cn(C)nc2C(C)(C)C)no1,nitro
213257,Modify the molecule C#CCN(CC#C)CC(=O)N[C@@H](C)C(=O)N(C)C by adding a benzene ring.,C#CCN(CC#C)CC(=O)N[C@@H](C)C(=O)N(C)C,benzene ring
160125,Please add a halo to the molecule Cc1cccc(C)c1NC(=O)CSCc1ccon1.,Cc1cccc(C)c1NC(=O)CSCc1ccon1,halo
243012,Please add a hydroxyl to the molecule C=CCNC(=O)c1cc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)ccc1F.,C=CCNC(=O)c1cc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)ccc1F,hydroxyl
32777,Modify the molecule CN(C)/C=C(/C(=O)C(F)(F)F)c1ncc(C(F)(F)F)cc1Cl by adding a hydroxyl.,CN(C)/C=C(/C(=O)C(F)(F)F)c1ncc(C(F)(F)F)cc1Cl,hydroxyl
233584,Please add a hydroxyl to the molecule Cc1nnc(NCCCc2c(C)noc2C)s1.,Cc1nnc(NCCCc2c(C)noc2C)s1,hydroxyl
177523,Add a carboxyl to the molecule O=C(NC[C@H]1CCN(c2ccccc2)C1)[C@H]1CC=CCC1.,O=C(NC[C@H]1CCN(c2ccccc2)C1)[C@H]1CC=CCC1,carboxyl
177568,Please add a amide to the molecule O=C(CCSC1=[NH+]CCN1)N1CCOCC1.,O=C(CCSC1=[NH+]CCN1)N1CCOCC1,amide
32212,Please add a benzene ring to the molecule Cc1cccc(C(=O)NCC(=O)NCCc2ccc(F)cc2C)c1.,Cc1cccc(C(=O)NCC(=O)NCCc2ccc(F)cc2C)c1,benzene ring
163767,Modify the molecule N#Cc1ccc(NC[C@H](O)c2c(F)cccc2F)c(C(F)(F)F)c1 by adding a amide.,N#Cc1ccc(NC[C@H](O)c2c(F)cccc2F)c(C(F)(F)F)c1,amide
115459,Please add a amide to the molecule Cc1ccc(/C=C2\SC(=O)N(CCNC(=O)c3ccc(C)s3)C2=O)cc1.,Cc1ccc(/C=C2\SC(=O)N(CCNC(=O)c3ccc(C)s3)C2=O)cc1,amide
60203,Add a aldehyde to the molecule COc1cc(C[NH+](CCO)Cc2cccnc2)c(Br)cc1O.,COc1cc(C[NH+](CCO)Cc2cccnc2)c(Br)cc1O,aldehyde
79150,Modify the molecule Cc1ccc(NC(=O)[C@@H](C)[NH+](C)CCC(C)C)c(C)c1 by adding a benzene ring.,Cc1ccc(NC(=O)[C@@H](C)[NH+](C)CCC(C)C)c(C)c1,benzene ring
142414,Modify the molecule C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1 by adding a amide.,C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1,amide
104910,Please add a hydroxyl to the molecule Cc1cc(NC(=O)C[NH+](C)[C@H](C)C(=O)Nc2ccccc2C#N)no1.,Cc1cc(NC(=O)C[NH+](C)[C@H](C)C(=O)Nc2ccccc2C#N)no1,hydroxyl
152379,Modify the molecule O=C(Nc1ccc2c(c1)CN(C(=O)C1CC1)CC2)[C@H]1CC(=O)N(c2ccc(Cl)cc2)C1 by adding a halo.,O=C(Nc1ccc2c(c1)CN(C(=O)C1CC1)CC2)[C@H]1CC(=O)N(c2ccc(Cl)cc2)C1,halo
86611,Add a halo to the molecule CNc1snc(C)c1-c1nnc2cc(C)ncn12.,CNc1snc(C)c1-c1nnc2cc(C)ncn12,halo
136229,Please add a carboxyl to the molecule CN(C(=O)/C=C/c1ccnc(Cl)c1)c1cccc2ncccc12.,CN(C(=O)/C=C/c1ccnc(Cl)c1)c1cccc2ncccc12,carboxyl
174677,Modify the molecule COc1cc(CC(C)=O)cc(OC)c1OC by adding a hydroxyl.,COc1cc(CC(C)=O)cc(OC)c1OC,hydroxyl
9082,Modify the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)N1CC(C(=O)[O-])C1 by adding a thiol.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)N1CC(C(=O)[O-])C1,thiol
149043,Modify the molecule C[C@H](c1cccc2ccccc12)N(C)CC(C)(C)C[NH3+] by adding a amide.,C[C@H](c1cccc2ccccc12)N(C)CC(C)(C)C[NH3+],amide
45165,Modify the molecule CC[NH+](CC(=O)N1CCC[C@H](C(C)(C)C(=O)OC)C1)C1CC1 by adding a amide.,CC[NH+](CC(=O)N1CCC[C@H](C(C)(C)C(=O)OC)C1)C1CC1,amide
174465,Please add a nitro to the molecule CCOc1cc(/C=C/C(=O)N2CCC[C@@H](CNC(C)=O)C2)cc(Cl)c1OC.,CCOc1cc(/C=C/C(=O)N2CCC[C@@H](CNC(C)=O)C2)cc(Cl)c1OC,nitro
206039,Modify the molecule CN1CCO[C@H](C(=O)NCC(C)(C)[NH+]2CCCCC2)C1 by adding a thiol.,CN1CCO[C@H](C(=O)NCC(C)(C)[NH+]2CCCCC2)C1,thiol
181483,Modify the molecule CC[NH+]1CCc2c(sc3c2C(O)=N[C@H](/C=C\c2ccc([N+](=O)[O-])cc2)N3)C1 by adding a benzene ring.,CC[NH+]1CCc2c(sc3c2C(O)=N[C@H](/C=C\c2ccc([N+](=O)[O-])cc2)N3)C1,benzene ring
155887,Add a carboxyl to the molecule Cc1cn2c([nH+]1)CC[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)s1)C2.,Cc1cn2c([nH+]1)CC[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)s1)C2,carboxyl
185298,Add a hydroxyl to the molecule COC(=O)c1cc(C(=O)N2CCN(c3ccccc3)CC2)cc([N+](=O)[O-])c1.,COC(=O)c1cc(C(=O)N2CCN(c3ccccc3)CC2)cc([N+](=O)[O-])c1,hydroxyl
202174,Add a hydroxyl to the molecule CC[C@@H](C)c1ccc(NC(=O)c2ccc(C)nc2)cc1.,CC[C@@H](C)c1ccc(NC(=O)c2ccc(C)nc2)cc1,hydroxyl
224986,Please add a hydroxyl to the molecule CCc1ncc(S(=O)(=O)N2CCCCC[C@H]2CC(C)=O)[nH]1.,CCc1ncc(S(=O)(=O)N2CCCCC[C@H]2CC(C)=O)[nH]1,hydroxyl
235152,Add a carboxyl to the molecule COc1ccc(CCNC(=O)N[C@H](C)c2ccc(F)c(Cl)c2)cc1OC.,COc1ccc(CCNC(=O)N[C@H](C)c2ccc(F)c(Cl)c2)cc1OC,carboxyl
64015,Please add a amine to the molecule COC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)N(C(=O)c2cccs2)C2CC2)c1C.,COC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)N(C(=O)c2cccs2)C2CC2)c1C,amine
33550,Add a halo to the molecule C[C@H]1C[C@H](C)CN(S(=O)(=O)c2cccc(C(=O)NCCOc3ccccc3)c2)C1.,C[C@H]1C[C@H](C)CN(S(=O)(=O)c2cccc(C(=O)NCCOc3ccccc3)c2)C1,halo
171508,Modify the molecule Cc1ccc([C@@H]2C[C@H](c3ccccc3)n3ncnc3N2C(=O)c2ccccc2[N+](=O)[O-])cc1 by adding a aldehyde.,Cc1ccc([C@@H]2C[C@H](c3ccccc3)n3ncnc3N2C(=O)c2ccccc2[N+](=O)[O-])cc1,aldehyde
79230,Please add a amine to the molecule CCn1cc(/C=C2/Oc3c(ccc4c3CN([C@@H]3CCS(=O)(=O)C3)CO4)C2=O)c2ccccc21.,CCn1cc(/C=C2/Oc3c(ccc4c3CN([C@@H]3CCS(=O)(=O)C3)CO4)C2=O)c2ccccc21,amine
60482,Modify the molecule C[C@@H](NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1)c1ccccc1-n1cccn1 by adding a amide.,C[C@@H](NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1)c1ccccc1-n1cccn1,amide
77980,Please add a benzene ring to the molecule CCOC(=O)[C@@H]1CC(C)(C)C(=O)N1C(=O)OC(C)(C)C.,CCOC(=O)[C@@H]1CC(C)(C)C(=O)N1C(=O)OC(C)(C)C,benzene ring
53946,Add a amide to the molecule Cc1c(NC(=O)[C@H]2CN(C)CCO2)cccc1[N+](=O)[O-].,Cc1c(NC(=O)[C@H]2CN(C)CCO2)cccc1[N+](=O)[O-],amide
244425,Add a amine to the molecule CC[C@@H]([NH2+]Cc1cc(F)ccc1F)c1ccc(OC)cc1.,CC[C@@H]([NH2+]Cc1cc(F)ccc1F)c1ccc(OC)cc1,amine
118482,Please add a amide to the molecule CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C.,CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C,amide
199065,Add a amide to the molecule C[NH+](CCNS(C)(=O)=O)C1CCC(c2ccc(O)cc2)CC1.,C[NH+](CCNS(C)(=O)=O)C1CCC(c2ccc(O)cc2)CC1,amide
102659,Modify the molecule C[NH+](Cc1cc(C(C)(C)C)n[nH]1)Cc1ncc[nH]1 by adding a amide.,C[NH+](Cc1cc(C(C)(C)C)n[nH]1)Cc1ncc[nH]1,amide
120645,Please add a amine to the molecule CC[C@@H](C)c1nc(Cl)nn1-c1ccc(OC)cc1.,CC[C@@H](C)c1nc(Cl)nn1-c1ccc(OC)cc1,amine
150758,Add a carboxyl to the molecule COC(=O)c1[nH]c(C)c(C(=O)Nc2ccc3c(C)n[nH]c3c2)c1C.,COC(=O)c1[nH]c(C)c(C(=O)Nc2ccc3c(C)n[nH]c3c2)c1C,carboxyl
31996,Modify the molecule C[NH2+][C@H](C)c1cc(F)ccc1O[C@H](C)C(=O)NC1CC1 by adding a benzene ring.,C[NH2+][C@H](C)c1cc(F)ccc1O[C@H](C)C(=O)NC1CC1,benzene ring
121671,Modify the molecule CC[C@@H](C)C1=CC(=O)CCC1 by adding a hydroxyl.,CC[C@@H](C)C1=CC(=O)CCC1,hydroxyl
6949,Please add a benzene ring to the molecule C=C(C)C[C@@H]([NH2+]CC)c1ccc(F)c(C)c1.,C=C(C)C[C@@H]([NH2+]CC)c1ccc(F)c(C)c1,benzene ring
240526,Modify the molecule O=C(Nc1ccc(O)cc1)[C@H]1CC=CC[C@H]1C(=O)[O-] by adding a amine.,O=C(Nc1ccc(O)cc1)[C@H]1CC=CC[C@H]1C(=O)[O-],amine
175582,Modify the molecule CS[C@@H](C)c1cccc(NC(=O)c2cn(C)nc2-c2ccccc2)c1 by adding a carboxyl.,CS[C@@H](C)c1cccc(NC(=O)c2cn(C)nc2-c2ccccc2)c1,carboxyl
129750,Modify the molecule CCC[NH+](C1CC1)[C@H]1CCC[C@@H]1C#N by adding a nitro.,CCC[NH+](C1CC1)[C@H]1CCC[C@@H]1C#N,nitro
242308,Modify the molecule Cc1ccnc(-c2n[nH]c(CO)n2)c1 by adding a halo.,Cc1ccnc(-c2n[nH]c(CO)n2)c1,halo
166233,Modify the molecule COc1ccc2c(c1)=C(CCNS(=O)(=O)c1cc(C)c(OC)cc1C)[C@H](C)[NH+]=2 by adding a halo.,COc1ccc2c(c1)=C(CCNS(=O)(=O)c1cc(C)c(OC)cc1C)[C@H](C)[NH+]=2,halo
175184,Modify the molecule CC(C)c1ccc(C(=O)NCc2cnn(C)c2N)cc1 by adding a amine.,CC(C)c1ccc(C(=O)NCc2cnn(C)c2N)cc1,amine
191918,Modify the molecule COc1ccc(O[C@H](C)CNC(=O)c2cccc(-c3nnc(C)o3)c2)cc1 by adding a amine.,COc1ccc(O[C@H](C)CNC(=O)c2cccc(-c3nnc(C)o3)c2)cc1,amine
225615,Please add a halo to the molecule NS(=O)(=O)c1ccc(CCNC(=O)Cn2c3ccccc3c(=O)c3ccccc32)cc1.,NS(=O)(=O)c1ccc(CCNC(=O)Cn2c3ccccc3c(=O)c3ccccc32)cc1,halo
67891,Please add a amine to the molecule C/C(=C/CCCl)c1ccc(F)cc1F.,C/C(=C/CCCl)c1ccc(F)cc1F,amine
27119,Add a nitro to the molecule CC(C)C(=O)N[C@@H]1CCC[NH+](CCS(=O)(=O)c2ccc(C#N)cc2)C1.,CC(C)C(=O)N[C@@H]1CCC[NH+](CCS(=O)(=O)c2ccc(C#N)cc2)C1,nitro
183960,Modify the molecule O=C(Nc1ccc([N+](=O)[O-])cc1)N1CCCCC[C@H]1c1ccncc1 by adding a amide.,O=C(Nc1ccc([N+](=O)[O-])cc1)N1CCCCC[C@H]1c1ccncc1,amide
58779,Add a halo to the molecule Fc1ccc(Nc2ccnc(Cl)n2)cc1.,Fc1ccc(Nc2ccnc(Cl)n2)cc1,halo
239772,Modify the molecule CC(C)[C@H]([NH2+]CC1CCC(C(=O)[O-])CC1)c1ccccc1 by adding a hydroxyl.,CC(C)[C@H]([NH2+]CC1CCC(C(=O)[O-])CC1)c1ccccc1,hydroxyl
81308,Add a benzene ring to the molecule COc1cccc(CNC(=O)[C@@H](C)C2CCN(C(=O)c3cc4ccc(OC)cc4[nH]3)CC2)c1.,COc1cccc(CNC(=O)[C@@H](C)C2CCN(C(=O)c3cc4ccc(OC)cc4[nH]3)CC2)c1,benzene ring
150033,Modify the molecule CCc1nnc(NC(=O)C(C)(C)Nc2ccc([N+](=O)[O-])cc2)s1 by adding a benzene ring.,CCc1nnc(NC(=O)C(C)(C)Nc2ccc([N+](=O)[O-])cc2)s1,benzene ring
77472,Add a amide to the molecule CC/C(=C/C(=O)[C@H](Cc1ccc(Cl)cc1Cl)C(=O)[O-])N(C)C.,CC/C(=C/C(=O)[C@H](Cc1ccc(Cl)cc1Cl)C(=O)[O-])N(C)C,amide
20839,Modify the molecule O=C([C@H]1COc2ccccc2O1)N1CCC(Cn2ccc3cccnc32)CC1 by adding a hydroxyl.,O=C([C@H]1COc2ccccc2O1)N1CCC(Cn2ccc3cccnc32)CC1,hydroxyl
1363,Modify the molecule NC(=O)[C@]1([NH2+]C2CC2)CC[C@H](Oc2cc(F)cc(F)c2)C1 by adding a nitro.,NC(=O)[C@]1([NH2+]C2CC2)CC[C@H](Oc2cc(F)cc(F)c2)C1,nitro
80627,Please add a benzene ring to the molecule COc1ccc([C@H](NC(=O)N2C[C@H]3CC=CC[C@H]3C2)C2CCOCC2)cc1.,COc1ccc([C@H](NC(=O)N2C[C@H]3CC=CC[C@H]3C2)C2CCOCC2)cc1,benzene ring
157102,Add a aldehyde to the molecule COCC[NH2+]CC(=O)N[C@H]1CCC[C@H]1n1cc[nH+]c1.,COCC[NH2+]CC(=O)N[C@H]1CCC[C@H]1n1cc[nH+]c1,aldehyde
8146,Add a nitro to the molecule COC(=O)c1sccc1NC(=O)C[NH+](C)[C@H](C)C1CC1.,COC(=O)c1sccc1NC(=O)C[NH+](C)[C@H](C)C1CC1,nitro
172323,Add a hydroxyl to the molecule CCN1c2ccccc2C2=C([C@@H](c3cccc(F)c3)C(C#N)=C(N)O2)S1(=O)=O.,CCN1c2ccccc2C2=C([C@@H](c3cccc(F)c3)C(C#N)=C(N)O2)S1(=O)=O,hydroxyl
71335,Please add a benzene ring to the molecule COc1ccc(C(=O)OCc2nncn2C2CC2)cc1-c1ccccc1.,COc1ccc(C(=O)OCc2nncn2C2CC2)cc1-c1ccccc1,benzene ring
211063,Modify the molecule CC[NH+]1CCC[C@@H](n2c([C@@H](C)Cl)nc3cnccc32)C1 by adding a amide.,CC[NH+]1CCC[C@@H](n2c([C@@H](C)Cl)nc3cnccc32)C1,amide
45629,Modify the molecule COc1cccc(C[C@]2(c3ccc(C)cc3)NC(N)=NC2=O)c1 by adding a halo.,COc1cccc(C[C@]2(c3ccc(C)cc3)NC(N)=NC2=O)c1,halo
45149,Please add a amide to the molecule [NH3+][C@H]1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C[C@@H]1C(=O)[O-].,[NH3+][C@H]1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C[C@@H]1C(=O)[O-],amide
245925,Please add a benzene ring to the molecule Cc1cccc(C(C)(C)O)c1N.,Cc1cccc(C(C)(C)O)c1N,benzene ring
10016,Modify the molecule C/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccccc1O by adding a hydroxyl.,C/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccccc1O,hydroxyl
7213,Please add a benzene ring to the molecule COc1ccc(CN(C)C(=O)C[NH2+]C(C)C)cc1OC.,COc1ccc(CN(C)C(=O)C[NH2+]C(C)C)cc1OC,benzene ring
123318,Please add a nitro to the molecule COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1.,COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1,nitro
82310,Modify the molecule Cc1ccc(CN2CCN([C@H](C)C(=O)N3CCOCC3)CC2)cc1[N+](=O)[O-] by adding a hydroxyl.,Cc1ccc(CN2CCN([C@H](C)C(=O)N3CCOCC3)CC2)cc1[N+](=O)[O-],hydroxyl
70137,Add a amide to the molecule CCC(=O)Nc1cccc(NC(=O)c2ccc(Cl)cc2)c1C.,CCC(=O)Nc1cccc(NC(=O)c2ccc(Cl)cc2)c1C,amide
80269,Add a amide to the molecule CC(C)N(CC(=O)[O-])C(=O)C[C@@H]1CCCCO1.,CC(C)N(CC(=O)[O-])C(=O)C[C@@H]1CCCCO1,amide
244166,Add a hydroxyl to the molecule O=C([O-])CNC(=O)NCc1ccc(Cl)cc1.,O=C([O-])CNC(=O)NCc1ccc(Cl)cc1,hydroxyl
1063,Modify the molecule C[C@H](NC(=O)c1cc(-c2ccco2)[nH]n1)c1ccc(Cl)s1 by adding a amide.,C[C@H](NC(=O)c1cc(-c2ccco2)[nH]n1)c1ccc(Cl)s1,amide
208656,Modify the molecule O=C(Cc1ccccc1F)NNC(=O)NCCc1ccccc1Cl by adding a amide.,O=C(Cc1ccccc1F)NNC(=O)NCCc1ccccc1Cl,amide
206552,Modify the molecule COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1 by adding a amide.,COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1,amide
94083,Modify the molecule Cc1ccc(Nc2nn[nH]c2C(=O)NCc2cc(F)cc(F)c2)cc1C by adding a benzene ring.,Cc1ccc(Nc2nn[nH]c2C(=O)NCc2cc(F)cc(F)c2)cc1C,benzene ring
248777,Modify the molecule CC(C)NC(=O)CC[NH+]1CCc2ccccc2C1 by adding a benzene ring.,CC(C)NC(=O)CC[NH+]1CCc2ccccc2C1,benzene ring
75041,Modify the molecule CC(C)(CC[NH3+])CCC(=O)NC[C@@]1(C)CCCO1 by adding a halo.,CC(C)(CC[NH3+])CCC(=O)NC[C@@]1(C)CCCO1,halo
143399,Add a benzene ring to the molecule CSc1ccc(Cl)c(C(=O)NCc2ccc3c(c2)=C2CCCC[C@H]2[NH+]=3)c1.,CSc1ccc(Cl)c(C(=O)NCc2ccc3c(c2)=C2CCCC[C@H]2[NH+]=3)c1,benzene ring
243687,Add a hydroxyl to the molecule COc1cc(C(=O)N[C@@H](c2nc3ccccc3[nH]2)C(C)C)cc(OC)c1Br.,COc1cc(C(=O)N[C@@H](c2nc3ccccc3[nH]2)C(C)C)cc(OC)c1Br,hydroxyl
37476,Modify the molecule CCc1nc(C(=O)Nc2cc(NC(C)=O)ccc2F)n[nH]1 by adding a hydroxyl.,CCc1nc(C(=O)Nc2cc(NC(C)=O)ccc2F)n[nH]1,hydroxyl
62923,Please add a hydroxyl to the molecule C=CCOc1ccccc1/C=C/C[NH2+]CC.,C=CCOc1ccccc1/C=C/C[NH2+]CC,hydroxyl
168568,Modify the molecule Nc1nc(CSc2ncc(Cl)cc2Cl)nc(Nc2ccccc2)n1 by adding a halo.,Nc1nc(CSc2ncc(Cl)cc2Cl)nc(Nc2ccccc2)n1,halo
206834,Please add a benzene ring to the molecule CC1(C)CCC[C@]1(O)[C@@H]1CCO[C@]2(CCSC2)C1.,CC1(C)CCC[C@]1(O)[C@@H]1CCO[C@]2(CCSC2)C1,benzene ring
240380,Add a amide to the molecule Cc1cc(NC(=O)N2CCN([C@H](C)C(F)(F)F)CC2)ccc1N(C)C.,Cc1cc(NC(=O)N2CCN([C@H](C)C(F)(F)F)CC2)ccc1N(C)C,amide
90045,Please add a nitrile to the molecule CCc1cccc(N[C@H](C)C(=O)Nc2cccc(C(C)=O)c2)c1.,CCc1cccc(N[C@H](C)C(=O)Nc2cccc(C(C)=O)c2)c1,nitrile
62842,Please add a amine to the molecule CC[NH+](CC)CCNC(=O)c1ccc(NC(=O)N2CC[C@H](C)[C@H](O)C2)cc1.,CC[NH+](CC)CCNC(=O)c1ccc(NC(=O)N2CC[C@H](C)[C@H](O)C2)cc1,amine
218075,Add a thiol to the molecule O[C@@H](Cc1ccc(F)cc1)[C@@H]1CCO[C@]2(CCOC2)C1.,O[C@@H](Cc1ccc(F)cc1)[C@@H]1CCO[C@]2(CCOC2)C1,thiol
109715,Add a benzene ring to the molecule Cc1ccn2c(=O)c(C(=O)Nc3ccc4c(c3)OCO4)cnc2c1.,Cc1ccn2c(=O)c(C(=O)Nc3ccc4c(c3)OCO4)cnc2c1,benzene ring
96302,Please add a benzene ring to the molecule C=CCn1nns/c1=N/CC(=O)Nc1cccc(C(F)(F)F)c1.,C=CCn1nns/c1=N/CC(=O)Nc1cccc(C(F)(F)F)c1,benzene ring
193593,Please add a amine to the molecule C[C@@H](O)[C@H](O)C1=N[C@H]2C(=O)N=C([NH-])NC2=[NH+]C1.,C[C@@H](O)[C@H](O)C1=N[C@H]2C(=O)N=C([NH-])NC2=[NH+]C1,amine
22577,Please add a hydroxyl to the molecule CCCCCNC(=O)[C@H](C)Oc1ccc(C#N)c(F)c1.,CCCCCNC(=O)[C@H](C)Oc1ccc(C#N)c(F)c1,hydroxyl
22590,Add a amine to the molecule Cc1ccc(C2=NS(=O)(=O)N(C)C(C(=O)N3CCN(Cc4ccccc4)CC3)=C2)cc1.,Cc1ccc(C2=NS(=O)(=O)N(C)C(C(=O)N3CCN(Cc4ccccc4)CC3)=C2)cc1,amine
116153,Please add a benzene ring to the molecule CCOC(=O)[C@@H](C)Sc1nc(C)c(C(C)=O)cc1C#N.,CCOC(=O)[C@@H](C)Sc1nc(C)c(C(C)=O)cc1C#N,benzene ring
163480,Add a thiol to the molecule Cc1ccc(CCC(=O)OC[C@@H]2CCCN2C(N)=O)o1.,Cc1ccc(CCC(=O)OC[C@@H]2CCCN2C(N)=O)o1,thiol
53191,Please add a hydroxyl to the molecule COc1ccc(CNC(=O)CSCc2nsnc2C)cc1.,COc1ccc(CNC(=O)CSCc2nsnc2C)cc1,hydroxyl
157791,Please add a benzene ring to the molecule C[C@H]1CCC[NH+]([C@@H]2CCC[C@H](O)C2)C1.,C[C@H]1CCC[NH+]([C@@H]2CCC[C@H](O)C2)C1,benzene ring
5277,Modify the molecule CC(=O)N[C@H](CC(=O)N(C)[C@H]1CCc2ccccc2C1)c1ccccc1 by adding a benzene ring.,CC(=O)N[C@H](CC(=O)N(C)[C@H]1CCc2ccccc2C1)c1ccccc1,benzene ring
168472,Please add a amine to the molecule Nc1cc(F)ccc1-c1nc2cc(Cl)ccc2[nH]1.,Nc1cc(F)ccc1-c1nc2cc(Cl)ccc2[nH]1,amine
107925,Please add a carboxyl to the molecule C[C@@H](NC(=O)CN1CCN(c2ccc(O)cc2)CC1)c1ccccc1Cl.,C[C@@H](NC(=O)CN1CCN(c2ccc(O)cc2)CC1)c1ccccc1Cl,carboxyl
101033,Please add a benzene ring to the molecule Cc1ccc(NC(=O)c2sc(-n3nc(C)c(Cl)c3C)nc2C)cc1C.,Cc1ccc(NC(=O)c2sc(-n3nc(C)c(Cl)c3C)nc2C)cc1C,benzene ring
109476,Modify the molecule Cn1/c(=N/C(=O)Cc2ccc3c(c2)OCO3)sc2cc3c(cc21)OCCO3 by adding a benzene ring.,Cn1/c(=N/C(=O)Cc2ccc3c(c2)OCO3)sc2cc3c(cc21)OCCO3,benzene ring
6934,Add a carboxyl to the molecule O=S(=O)(NC[C@@H]1C[NH+]2CCN1CC2)c1ccc(C(F)(F)F)cc1.,O=S(=O)(NC[C@@H]1C[NH+]2CCN1CC2)c1ccc(C(F)(F)F)cc1,carboxyl
115579,Modify the molecule COc1ccc(OC)c(N2C[C@H](C(=O)N(C)C)CC2=O)c1 by adding a benzene ring.,COc1ccc(OC)c(N2C[C@H](C(=O)N(C)C)CC2=O)c1,benzene ring
28409,Add a amine to the molecule Cn1ncc2c1N=C(O)C[C@H]2c1cc(Cl)ccc1F.,Cn1ncc2c1N=C(O)C[C@H]2c1cc(Cl)ccc1F,amine
38199,Modify the molecule Cc1oc(-c2cccs2)nc1C[NH+](C)CC(=O)[O-] by adding a carboxyl.,Cc1oc(-c2cccs2)nc1C[NH+](C)CC(=O)[O-],carboxyl
13322,Add a aldehyde to the molecule C[C@@H]1CC[NH+](CCCN2C(=O)NC(C)(C)C2=O)[C@H](C)C1.,C[C@@H]1CC[NH+](CCCN2C(=O)NC(C)(C)C2=O)[C@H](C)C1,aldehyde
103051,Add a benzene ring to the molecule Cc1ccc(C)c(/N=C/c2ccc(Cl)c([N+](=O)[O-])c2)c1.,Cc1ccc(C)c(/N=C/c2ccc(Cl)c([N+](=O)[O-])c2)c1,benzene ring
196060,Modify the molecule CC[NH2+][C@@H]1CCC[C@@H]1c1cscc1Br by adding a aldehyde.,CC[NH2+][C@@H]1CCC[C@@H]1c1cscc1Br,aldehyde
50013,Please add a amide to the molecule NS(=O)(=O)c1cscc1Br.,NS(=O)(=O)c1cscc1Br,amide
105714,Modify the molecule COc1cc2c(cc1OC)[C@@H](C(=O)Nc1cccc(C)n1)[C@H](c1cccs1)N(C)C2=O by adding a benzene ring.,COc1cc2c(cc1OC)[C@@H](C(=O)Nc1cccc(C)n1)[C@H](c1cccs1)N(C)C2=O,benzene ring
39029,Modify the molecule CCc1noc(CC)c1CNC(=O)Nc1cccc(-n2nnnc2C)c1 by adding a nitro.,CCc1noc(CC)c1CNC(=O)Nc1cccc(-n2nnnc2C)c1,nitro
65843,Modify the molecule O=C(NO[C@H]1CCCCO1)c1cc([N+](=O)[O-])ccc1Cl by adding a amide.,O=C(NO[C@H]1CCCCO1)c1cc([N+](=O)[O-])ccc1Cl,amide
20095,Modify the molecule C[C@@H](OC(=O)[C@H]1CCCc2[nH]ncc21)c1ccc(Cl)s1 by adding a amide.,C[C@@H](OC(=O)[C@H]1CCCc2[nH]ncc21)c1ccc(Cl)s1,amide
202547,Please add a benzene ring to the molecule COC(=O)C1=C(NC(=O)c2ccc(OC)cc2)CCS1.,COC(=O)C1=C(NC(=O)c2ccc(OC)cc2)CCS1,benzene ring
82781,Please add a hydroxyl to the molecule COc1cccc(C[NH+]2CC[C@@H](C)[C@@H](n3ccnc3)C2)c1OC(C)C.,COc1cccc(C[NH+]2CC[C@@H](C)[C@@H](n3ccnc3)C2)c1OC(C)C,hydroxyl
215180,Modify the molecule Cc1ccc([C@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N(C4CCCC4)CC(=O)N23)cc1 by adding a benzene ring.,Cc1ccc([C@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N(C4CCCC4)CC(=O)N23)cc1,benzene ring
186737,Add a amide to the molecule CCC[NH2+][C@@H](Cc1ccccn1)c1ccc(CC)o1.,CCC[NH2+][C@@H](Cc1ccccn1)c1ccc(CC)o1,amide
80559,Modify the molecule O=C(/C=C/c1ccc(OC(F)F)cc1OC(F)F)N1CCOCC1 by adding a carboxyl.,O=C(/C=C/c1ccc(OC(F)F)cc1OC(F)F)N1CCOCC1,carboxyl
65560,Add a hydroxyl to the molecule Cc1ccc(C(=O)N2C[C@@H](C)C[C@H](C)C2)cn1.,Cc1ccc(C(=O)N2C[C@@H](C)C[C@H](C)C2)cn1,hydroxyl
150256,Modify the molecule CC(C)[C@H]1CC[C@H](C)C[C@@H]1OC(=O)C[N+](C)(C)CCO by adding a carboxyl.,CC(C)[C@H]1CC[C@H](C)C[C@@H]1OC(=O)C[N+](C)(C)CCO,carboxyl
7681,Modify the molecule COc1ccc(Br)cc1CSc1cc(N)ccc1Cl by adding a aldehyde.,COc1ccc(Br)cc1CSc1cc(N)ccc1Cl,aldehyde
33291,Add a benzene ring to the molecule CCc1nn(C)c2c1nc(CCl)n2Cc1ccc(C)cc1.,CCc1nn(C)c2c1nc(CCl)n2Cc1ccc(C)cc1,benzene ring
118656,Add a benzene ring to the molecule COc1cc(OC)c(-c2cc(C(=O)[O-])c3c(-c4ccc(Cl)cc4)[nH]nc3n2)cc1OC.,COc1cc(OC)c(-c2cc(C(=O)[O-])c3c(-c4ccc(Cl)cc4)[nH]nc3n2)cc1OC,benzene ring
190054,Add a amide to the molecule CC[C@@H](CS(=O)(=O)c1ccccc1)[NH2+][C@@H](C)c1ccc2c(c1)OCO2.,CC[C@@H](CS(=O)(=O)c1ccccc1)[NH2+][C@@H](C)c1ccc2c(c1)OCO2,amide
41309,Please add a amide to the molecule Cc1cc(C[NH+](C)Cc2nc(-c3cccnc3)no2)ccc1-n1cncn1.,Cc1cc(C[NH+](C)Cc2nc(-c3cccnc3)no2)ccc1-n1cncn1,amide
11995,Please add a hydroxyl to the molecule c1ccc2[nH]c(SC[C@@H]3CC[NH2+]C3)nc2c1.,c1ccc2[nH]c(SC[C@@H]3CC[NH2+]C3)nc2c1,hydroxyl
158040,Modify the molecule Cc1csc(NC(=O)c2ccc(N3C(=O)[C@H](C)CS3(=O)=O)cc2Cl)n1 by adding a hydroxyl.,Cc1csc(NC(=O)c2ccc(N3C(=O)[C@H](C)CS3(=O)=O)cc2Cl)n1,hydroxyl
39915,Add a hydroxyl to the molecule c1cn2c(CN3CC[C@H](C[NH+]4CCCCC4)C3)cnc2cn1.,c1cn2c(CN3CC[C@H](C[NH+]4CCCCC4)C3)cnc2cn1,hydroxyl
197629,Modify the molecule COC(=O)c1c(C)[nH]c(C(=O)[C@@H](C)Sc2nnc3cc(C)c4ccccc4n23)c1C by adding a benzene ring.,COC(=O)c1c(C)[nH]c(C(=O)[C@@H](C)Sc2nnc3cc(C)c4ccccc4n23)c1C,benzene ring
132229,Modify the molecule O=C([O-])[C@@H]1CC[C@@H](CN2C(=O)CC3(CCCC3)CC2=O)O1 by adding a hydroxyl.,O=C([O-])[C@@H]1CC[C@@H](CN2C(=O)CC3(CCCC3)CC2=O)O1,hydroxyl
216702,Please add a hydroxyl to the molecule Cc1cc(F)ccc1CCN1CCC([NH3+])CC1.,Cc1cc(F)ccc1CCN1CCC([NH3+])CC1,hydroxyl
46394,Modify the molecule Cc1noc(-c2cccnc2N2CCC[C@@H](NC(=O)C(C)C)C2)n1 by adding a amide.,Cc1noc(-c2cccnc2N2CCC[C@@H](NC(=O)C(C)C)C2)n1,amide
21208,Please add a benzene ring to the molecule CCC[C@H]1[C@H](C)CCC[NH+]1Cc1ncc(C)o1.,CCC[C@H]1[C@H](C)CCC[NH+]1Cc1ncc(C)o1,benzene ring
109704,Please add a benzene ring to the molecule CC(C)[NH+](Cc1csc(-c2cnn(C)c2)n1)C1CCOCC1.,CC(C)[NH+](Cc1csc(-c2cnn(C)c2)n1)C1CCOCC1,benzene ring
24524,Modify the molecule CCCn1/c(=N/C(=O)[C@@H]2COc3ccccc3O2)sc2cc(OC)ccc21 by adding a amide.,CCCn1/c(=N/C(=O)[C@@H]2COc3ccccc3O2)sc2cc(OC)ccc21,amide
158493,Add a amine to the molecule COc1ccccc1NC(=O)c1cc(C)n(Cc2ccccn2)c1C.,COc1ccccc1NC(=O)c1cc(C)n(Cc2ccccn2)c1C,amine
86581,Add a benzene ring to the molecule CC(C)(C)OC(=O)NC[C@H]1CCC[NH+]1CC(=O)Nc1sccc1C#N.,CC(C)(C)OC(=O)NC[C@H]1CCC[NH+]1CC(=O)Nc1sccc1C#N,benzene ring
44289,Add a carboxyl to the molecule CCOc1ccccc1/C=C/C(=O)Oc1ccc(Br)cc1.,CCOc1ccccc1/C=C/C(=O)Oc1ccc(Br)cc1,carboxyl
193689,Modify the molecule C[NH+]1CCN(C(=O)CN2CCC[C@@H]([NH+]3CCCCCC3)C2)CC1 by adding a benzene ring.,C[NH+]1CCN(C(=O)CN2CCC[C@@H]([NH+]3CCCCCC3)C2)CC1,benzene ring
87469,Modify the molecule Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1 by adding a nitro.,Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1,nitro
249239,Add a nitro to the molecule Cc1ccc(C(C)C)c(OCC(=O)N/N=C/c2ccco2)c1.,Cc1ccc(C(C)C)c(OCC(=O)N/N=C/c2ccco2)c1,nitro
8538,Modify the molecule COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1 by adding a benzene ring.,COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1,benzene ring
162999,Modify the molecule CC(=O)Oc1ccccc1C(=O)Nc1ccc(Cl)cc1Cl by adding a amide.,CC(=O)Oc1ccccc1C(=O)Nc1ccc(Cl)cc1Cl,amide
241741,Add a benzene ring to the molecule CCc1nc(C)nc(N2CCN(C(=O)c3cccc(OC)c3)CC2)c1Cc1ccc(Cl)cc1.,CCc1nc(C)nc(N2CCN(C(=O)c3cccc(OC)c3)CC2)c1Cc1ccc(Cl)cc1,benzene ring
15607,Add a benzene ring to the molecule Cc1ccc(NC(=O)c2noc3c2CCCCC3)c(Cl)c1.,Cc1ccc(NC(=O)c2noc3c2CCCCC3)c(Cl)c1,benzene ring
21028,Please add a aldehyde to the molecule Cc1c(CCC(=O)Nc2cccc(-c3ccc4c(c3)CCO4)c2)cnn1C.,Cc1c(CCC(=O)Nc2cccc(-c3ccc4c(c3)CCO4)c2)cnn1C,aldehyde
206984,Add a hydroxyl to the molecule CN(C)c1ncccc1N(C)C(=O)[C@H]1CC(c2c(F)cccc2F)=NO1.,CN(C)c1ncccc1N(C)C(=O)[C@H]1CC(c2c(F)cccc2F)=NO1,hydroxyl
53761,Modify the molecule CC(C)Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(C#N)o3)CC2)cc1 by adding a hydroxyl.,CC(C)Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(C#N)o3)CC2)cc1,hydroxyl
160374,Modify the molecule C[C@@H](CNc1ncccc1C#N)Oc1ccccc1 by adding a carboxyl.,C[C@@H](CNc1ncccc1C#N)Oc1ccccc1,carboxyl
70308,Add a nitro to the molecule C[C@](O)(CNC(=O)Nc1ccccc1S(C)(=O)=O)c1ccc(F)cc1.,C[C@](O)(CNC(=O)Nc1ccccc1S(C)(=O)=O)c1ccc(F)cc1,nitro
28934,Add a amide to the molecule CN(Cc1[nH+]ccn1C)C(=O)[C@@H]1CC(=O)Nc2ccccc21.,CN(Cc1[nH+]ccn1C)C(=O)[C@@H]1CC(=O)Nc2ccccc21,amide
18887,Add a carboxyl to the molecule CC[C@H](NC(=O)N1CCC[C@@H]1c1ccccc1C)C(=O)N1CCOCC1.,CC[C@H](NC(=O)N1CCC[C@@H]1c1ccccc1C)C(=O)N1CCOCC1,carboxyl
169295,Add a halo to the molecule Fc1ccccc1C/[NH+]=C1\NCC[NH2+]C12CCCCC2.,Fc1ccccc1C/[NH+]=C1\NCC[NH2+]C12CCCCC2,halo
126572,Please add a hydroxyl to the molecule COc1cccc2c(C)c(C(=O)N[C@@H](C)C(=O)N3CCOCC3)oc12.,COc1cccc2c(C)c(C(=O)N[C@@H](C)C(=O)N3CCOCC3)oc12,hydroxyl
36119,Modify the molecule CC(C)CC1=NN=C2CCN(C(=O)c3ccc4ncsc4c3)C[C@H]21 by adding a hydroxyl.,CC(C)CC1=NN=C2CCN(C(=O)c3ccc4ncsc4c3)C[C@H]21,hydroxyl
4420,Modify the molecule Cc1cc(F)ccc1/C=C1\SC(=S)N([C@H](C)[C@H]2CCCO2)C1=O by adding a halo.,Cc1cc(F)ccc1/C=C1\SC(=S)N([C@H](C)[C@H]2CCCO2)C1=O,halo
181350,Please add a benzene ring to the molecule CCc1nc(C)c([C@H](C)NC[C@@H](OC)c2ccc(F)cc2)s1.,CCc1nc(C)c([C@H](C)NC[C@@H](OC)c2ccc(F)cc2)s1,benzene ring
10048,Modify the molecule C[C@@H](Oc1ccccc1C#N)C(=O)N1CCC[C@@H](C(F)(F)F)C1 by adding a carboxyl.,C[C@@H](Oc1ccccc1C#N)C(=O)N1CCC[C@@H](C(F)(F)F)C1,carboxyl
168638,Add a benzene ring to the molecule CCc1nn(C)c(CC)c1CNC(=O)[C@H]1CCO[C@H]1C.,CCc1nn(C)c(CC)c1CNC(=O)[C@H]1CCO[C@H]1C,benzene ring
11599,Please add a amide to the molecule CC(C)CC(=O)Nc1ccc2c(c1)[C@@H]1C=CC[C@H]1[C@H](c1ccccc1O)N2.,CC(C)CC(=O)Nc1ccc2c(c1)[C@@H]1C=CC[C@H]1[C@H](c1ccccc1O)N2,amide
118762,Add a benzene ring to the molecule Cc1ccc(-c2nc(C(=O)N[C@@H](C)c3nnc4ccccn34)cs2)cc1.,Cc1ccc(-c2nc(C(=O)N[C@@H](C)c3nnc4ccccn34)cs2)cc1,benzene ring
61168,Modify the molecule CC(=O)N1CCc2cc(S(=O)(=O)NC3CC[NH+](Cc4ccccc4)CC3)ccc21 by adding a benzene ring.,CC(=O)N1CCc2cc(S(=O)(=O)NC3CC[NH+](Cc4ccccc4)CC3)ccc21,benzene ring
24458,Please add a aldehyde to the molecule O=C(c1cc(N2CCC(c3nc4ccccc4s3)CC2)ccc1[N+](=O)[O-])N1CCCC1.,O=C(c1cc(N2CCC(c3nc4ccccc4s3)CC2)ccc1[N+](=O)[O-])N1CCCC1,aldehyde
127005,Add a hydroxyl to the molecule CN(CCOCC1CC1)C(=O)[C@@H]1CCCCN1S(C)(=O)=O.,CN(CCOCC1CC1)C(=O)[C@@H]1CCCCN1S(C)(=O)=O,hydroxyl
147267,Add a hydroxyl to the molecule CN(C)C(=O)[C@@]1(C)CCCN(c2ncccn2)C1.,CN(C)C(=O)[C@@]1(C)CCCN(c2ncccn2)C1,hydroxyl
212616,Please add a carboxyl to the molecule CCc1nnc(NC(=O)c2ccccc2NC(=O)c2ccc(C)c([N+](=O)[O-])c2)s1.,CCc1nnc(NC(=O)c2ccccc2NC(=O)c2ccc(C)c([N+](=O)[O-])c2)s1,carboxyl
27008,Add a benzene ring to the molecule O=C(C1CC[NH+](Cc2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1.,O=C(C1CC[NH+](Cc2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1,benzene ring
237476,Please add a benzene ring to the molecule CCN1CCN(C2=NC(=O)/C(=C/c3ccc(N(C)C)cc3)S2)CC1.,CCN1CCN(C2=NC(=O)/C(=C/c3ccc(N(C)C)cc3)S2)CC1,benzene ring
127598,Add a hydroxyl to the molecule CN(CCNC(=O)c1cnc(-c2ccncc2)nc1)S(C)(=O)=O.,CN(CCNC(=O)c1cnc(-c2ccncc2)nc1)S(C)(=O)=O,hydroxyl
20375,Add a hydroxyl to the molecule O=C([C@@H]1NCCc2[nH]c[nH+]c21)N1CCSCC1.,O=C([C@@H]1NCCc2[nH]c[nH+]c21)N1CCSCC1,hydroxyl
159556,Modify the molecule O=C(Nc1ccccc1F)O/N=C/c1ccncc1 by adding a hydroxyl.,O=C(Nc1ccccc1F)O/N=C/c1ccncc1,hydroxyl
106828,Add a benzene ring to the molecule COc1cc(CNC(=O)CNC(=O)C(C)(C)C)ccn1.,COc1cc(CNC(=O)CNC(=O)C(C)(C)C)ccn1,benzene ring
75107,Modify the molecule COC(=O)[C@@H]1C(=O)C2=C(C[C@@H]1C)NC(C)=C(C(=O)OC1CCCC1)[C@@H]2c1coc2ccccc2c1=O by adding a benzene ring.,COC(=O)[C@@H]1C(=O)C2=C(C[C@@H]1C)NC(C)=C(C(=O)OC1CCCC1)[C@@H]2c1coc2ccccc2c1=O,benzene ring
44382,Add a benzene ring to the molecule CN(CCS(C)(=O)=O)C(=O)Nc1ccccc1F.,CN(CCS(C)(=O)=O)C(=O)Nc1ccccc1F,benzene ring
194265,Modify the molecule COc1ccc(NC(=O)c2cccc(NC3=N[C@H]4CS(=O)(=O)C[C@@H]4S3)c2)cc1OC by adding a amide.,COc1ccc(NC(=O)c2cccc(NC3=N[C@H]4CS(=O)(=O)C[C@@H]4S3)c2)cc1OC,amide
54296,Modify the molecule CCOCc1ccccc1CNC(=O)NCc1nccc2ccccc12 by adding a carboxyl.,CCOCc1ccccc1CNC(=O)NCc1nccc2ccccc12,carboxyl
145455,Modify the molecule O=C(NC[C@H]1COc2ccccc2O1)Nc1ccc2c(c1)OCO2 by adding a benzene ring.,O=C(NC[C@H]1COc2ccccc2O1)Nc1ccc2c(c1)OCO2,benzene ring
199697,Please add a nitrile to the molecule C[C@H]1CC(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])C[C@H](C)O1.,C[C@H]1CC(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])C[C@H](C)O1,nitrile
122429,Modify the molecule O=C(Nc1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H]2CC(=O)N(c3ccccc3)C2)CC1 by adding a benzene ring.,O=C(Nc1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H]2CC(=O)N(c3ccccc3)C2)CC1,benzene ring
5273,Please add a halo to the molecule COC(=O)C[C@H](NC(=O)Nc1cc(F)ccc1F)c1ccc(OC)cc1.,COC(=O)C[C@H](NC(=O)Nc1cc(F)ccc1F)c1ccc(OC)cc1,halo
247074,Modify the molecule Cc1ccc(NC(=O)CCN2C(=O)/C(=C/c3ccccc3O)SC2=S)cc1 by adding a amine.,Cc1ccc(NC(=O)CCN2C(=O)/C(=C/c3ccccc3O)SC2=S)cc1,amine
198453,Please add a hydroxyl to the molecule Cc1cccc(O[C@@H](C)C(=O)N/N=C/c2ccc3c(c2)OCO3)c1.,Cc1cccc(O[C@@H](C)C(=O)N/N=C/c2ccc3c(c2)OCO3)c1,hydroxyl
132743,Modify the molecule Cc1ccc2ncc(C(=O)N3C[C@@H]4OCCN(C)[C@@H]4C3)n2c1 by adding a aldehyde.,Cc1ccc2ncc(C(=O)N3C[C@@H]4OCCN(C)[C@@H]4C3)n2c1,aldehyde
43455,Modify the molecule O=C(/C=C/c1ccccc1)Nc1ccc(S(=O)(=O)NC[C@H]2CCCO2)cc1 by adding a benzene ring.,O=C(/C=C/c1ccccc1)Nc1ccc(S(=O)(=O)NC[C@H]2CCCO2)cc1,benzene ring
21704,Please add a carboxyl to the molecule COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1.,COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1,carboxyl
197609,Add a aldehyde to the molecule CC(C)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1cc2ccncc2cn1.,CC(C)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1cc2ccncc2cn1,aldehyde
222563,Please add a amine to the molecule CC(=O)c1ccnc(Oc2cccc(Br)c2)c1.,CC(=O)c1ccnc(Oc2cccc(Br)c2)c1,amine
185355,Add a hydroxyl to the molecule COc1cc(C)ccc1NC(=O)c1cccc(OCc2cscn2)c1.,COc1cc(C)ccc1NC(=O)c1cccc(OCc2cscn2)c1,hydroxyl
91081,Please add a benzene ring to the molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3cccc(-c4ccccn4)c3)CC2)C1.,C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3cccc(-c4ccccn4)c3)CC2)C1,benzene ring
171196,Please add a aldehyde to the molecule CN1CC(=O)N(CC(=O)N[C@@H]2CCc3[nH+]ccn3C2)C1=O.,CN1CC(=O)N(CC(=O)N[C@@H]2CCc3[nH+]ccn3C2)C1=O,aldehyde
186701,Add a nitro to the molecule COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1.,COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1,nitro
110340,Modify the molecule CC[NH2+]C[C@H](Cc1cccc(F)c1F)c1cccc(C)c1 by adding a hydroxyl.,CC[NH2+]C[C@H](Cc1cccc(F)c1F)c1cccc(C)c1,hydroxyl
96351,Modify the molecule c1cc([C@@H]2C[C@H]2C[NH2+]C2CC2)ccc1C1CC1 by adding a amide.,c1cc([C@@H]2C[C@H]2C[NH2+]C2CC2)ccc1C1CC1,amide
149742,Modify the molecule C[C@H](NC(=O)N[C@H](C)C[C@@H](O)c1ccco1)c1ccc(Cl)s1 by adding a hydroxyl.,C[C@H](NC(=O)N[C@H](C)C[C@@H](O)c1ccco1)c1ccc(Cl)s1,hydroxyl
133521,Modify the molecule Cc1noc(C)c1C(=O)O[C@@H](C(=O)Nc1ccc(Cl)cc1C(F)(F)F)c1ccccc1 by adding a benzene ring.,Cc1noc(C)c1C(=O)O[C@@H](C(=O)Nc1ccc(Cl)cc1C(F)(F)F)c1ccccc1,benzene ring
26278,Add a benzene ring to the molecule C[C@@H](Nc1ncc(Br)cn1)c1cc2ccccc2o1.,C[C@@H](Nc1ncc(Br)cn1)c1cc2ccccc2o1,benzene ring
159369,Add a aldehyde to the molecule Cc1ccnc(NNC(=O)[C@H]2CCOc3ccccc32)c1.,Cc1ccnc(NNC(=O)[C@H]2CCOc3ccccc32)c1,aldehyde
157537,Please add a halo to the molecule C[C@H]1CC[C@@H]([NH+]2CCC[C@H](Cn3ccnn3)C2)C1.,C[C@H]1CC[C@@H]([NH+]2CCC[C@H](Cn3ccnn3)C2)C1,halo
170133,Please add a hydroxyl to the molecule CCN(Cc1cccs1)C(=O)NCC(C)(C)[NH+](C)C.,CCN(Cc1cccs1)C(=O)NCC(C)(C)[NH+](C)C,hydroxyl
49617,Add a hydroxyl to the molecule C[C@@H](C(=O)Nc1cccc(Cl)c1)[C@@H]1Sc2ccccc2NC1=O.,C[C@@H](C(=O)Nc1cccc(Cl)c1)[C@@H]1Sc2ccccc2NC1=O,hydroxyl
80483,Please add a hydroxyl to the molecule CCCCCN(C)S(N)(=O)=O.,CCCCCN(C)S(N)(=O)=O,hydroxyl
132190,Modify the molecule O=S(=O)(Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1)c1ccccc1 by adding a hydroxyl.,O=S(=O)(Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1)c1ccccc1,hydroxyl
16645,Please add a amide to the molecule CC1(C)[C@@H]([NH2+]Cc2cccnc2N2CCC[C@H](C(N)=O)C2)[C@@]2(C)CC[C@@H]1C2.,CC1(C)[C@@H]([NH2+]Cc2cccnc2N2CCC[C@H](C(N)=O)C2)[C@@]2(C)CC[C@@H]1C2,amide
93311,Please add a hydroxyl to the molecule CCOc1ccccc1OCCOc1ccccc1C#N.,CCOc1ccccc1OCCOc1ccccc1C#N,hydroxyl
124833,Add a benzene ring to the molecule CCc1nc2n(n1)CCC[C@@H]2NC(=O)NC[C@H]1CCO[C@@H]1C(C)(C)C.,CCc1nc2n(n1)CCC[C@@H]2NC(=O)NC[C@H]1CCO[C@@H]1C(C)(C)C,benzene ring
141798,Add a benzene ring to the molecule Cc1ncsc1CCC(=O)N1CCc2c([nH]c3ccccc23)[C@H]1C(C)(C)C.,Cc1ncsc1CCC(=O)N1CCc2c([nH]c3ccccc23)[C@H]1C(C)(C)C,benzene ring
225808,Modify the molecule Clc1ccccc1C[NH2+][C@@H]1CCO[C@@]2(CCOC2)C1 by adding a benzene ring.,Clc1ccccc1C[NH2+][C@@H]1CCO[C@@]2(CCOC2)C1,benzene ring
105617,Add a hydroxyl to the molecule ON(/C(=N\c1ccccc1)c1ccccc1Cl)c1ccccc1.,ON(/C(=N\c1ccccc1)c1ccccc1Cl)c1ccccc1,hydroxyl
71142,Please add a amine to the molecule C/[N+]([O-])=C\c1cccc(Br)c1.,C/[N+]([O-])=C\c1cccc(Br)c1,amine
60470,Modify the molecule CCC[C@@H]1CNc2c(C)[nH+]n(C)c2N1 by adding a benzene ring.,CCC[C@@H]1CNc2c(C)[nH+]n(C)c2N1,benzene ring
187485,Add a benzene ring to the molecule O=C(NCC[C@H]1C[C@H]2CC[C@@H]1C2)c1cccc(CN2C(=O)CNC2=O)c1.,O=C(NCC[C@H]1C[C@H]2CC[C@@H]1C2)c1cccc(CN2C(=O)CNC2=O)c1,benzene ring
178012,Add a benzene ring to the molecule Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc3c(c2)OCCO3)n1.,Cc1cccc(NC(=O)c2cc3ccccc3o/c2=[NH+]\c2ccc3c(c2)OCCO3)n1,benzene ring
132592,Add a benzene ring to the molecule O=C([O-])c1cc(SCCn2cccn2)cs1.,O=C([O-])c1cc(SCCn2cccn2)cs1,benzene ring
36327,Add a aldehyde to the molecule C/C(Nc1ccc(C(=O)[O-])c(O)c1)=C1/C(=O)O[C@H](C)C1=O.,C/C(Nc1ccc(C(=O)[O-])c(O)c1)=C1/C(=O)O[C@H](C)C1=O,aldehyde
182034,Modify the molecule Cn1c(SCc2noc(-c3ccccc3)n2)nc2ccsc2c1=O by adding a amine.,Cn1c(SCc2noc(-c3ccccc3)n2)nc2ccsc2c1=O,amine
145936,Add a amide to the molecule Cc1ccc(C)c([N-]S(=O)(=O)c2c(F)cccc2[N+](=O)[O-])c1.,Cc1ccc(C)c([N-]S(=O)(=O)c2c(F)cccc2[N+](=O)[O-])c1,amide
205281,Add a amide to the molecule CC[C@H](C)NC(=O)CN1CCN(C(=O)c2ccncc2Cl)CC1.,CC[C@H](C)NC(=O)CN1CCN(C(=O)c2ccncc2Cl)CC1,amide
174451,Add a hydroxyl to the molecule O=c1cc(CSc2cccc(Br)c2)nc2ccccn12.,O=c1cc(CSc2cccc(Br)c2)nc2ccccn12,hydroxyl
77907,Modify the molecule Cc1ccc2cccc(NC(=O)C(=O)NC[C@@H](C)C#N)c2n1 by adding a hydroxyl.,Cc1ccc2cccc(NC(=O)C(=O)NC[C@@H](C)C#N)c2n1,hydroxyl
98561,Modify the molecule C[C@@H]([NH2+][C@@H]1CCCc2sccc21)[C@H](OC1CCOCC1)c1ccccc1 by adding a benzene ring.,C[C@@H]([NH2+][C@@H]1CCCc2sccc21)[C@H](OC1CCOCC1)c1ccccc1,benzene ring
37190,Modify the molecule Cc1cccc(NC(=S)NNC(=O)[C@@H](C)NC(=O)c2ccccc2)c1C by adding a amide.,Cc1cccc(NC(=S)NNC(=O)[C@@H](C)NC(=O)c2ccccc2)c1C,amide
43372,Modify the molecule CCN(C(=O)[C@H](C)[S@@](=O)Cc1ccc(F)cc1F)c1ccccc1 by adding a carboxyl.,CCN(C(=O)[C@H](C)[S@@](=O)Cc1ccc(F)cc1F)c1ccccc1,carboxyl
79107,Modify the molecule O=C(CSc1nncs1)NC1CC[NH+](CC2CCCCC2)CC1 by adding a aldehyde.,O=C(CSc1nncs1)NC1CC[NH+](CC2CCCCC2)CC1,aldehyde
69141,Please add a aldehyde to the molecule COc1ccccc1CNC(=O)N[C@H]1CCCOc2ccccc21.,COc1ccccc1CNC(=O)N[C@H]1CCCOc2ccccc21,aldehyde
139209,Modify the molecule CCN(C(=O)c1cc(S(=O)(=O)N(C)C)c(C)o1)c1cc(C)ccc1C by adding a benzene ring.,CCN(C(=O)c1cc(S(=O)(=O)N(C)C)c(C)o1)c1cc(C)ccc1C,benzene ring
148559,Please add a benzene ring to the molecule C[C@@H]1CCc2c(sc3ncnc(NCCC4[NH+]=c5ccccc5=[NH+]4)c23)C1.,C[C@@H]1CCc2c(sc3ncnc(NCCC4[NH+]=c5ccccc5=[NH+]4)c23)C1,benzene ring
56499,Add a amide to the molecule C#CC[C@@H](C)OC(=O)c1cc(C)oc1C.,C#CC[C@@H](C)OC(=O)c1cc(C)oc1C,amide
36319,Add a hydroxyl to the molecule COCCOc1ccccc1CN1CCNC(=O)C[C@@H]1c1ccccc1.,COCCOc1ccccc1CN1CCNC(=O)C[C@@H]1c1ccccc1,hydroxyl
25319,Add a carboxyl to the molecule COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C.,COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C,carboxyl
195906,Modify the molecule CC(C)N(C[C@@H]1CCC(=O)N1)C(=O)c1cc(Cl)c[nH]c1=O by adding a halo.,CC(C)N(C[C@@H]1CCC(=O)N1)C(=O)c1cc(Cl)c[nH]c1=O,halo
91551,Add a halo to the molecule Cc1cc(C)n(-c2ccc(C(=O)Nc3ccccn3)nn2)n1.,Cc1cc(C)n(-c2ccc(C(=O)Nc3ccccn3)nn2)n1,halo
194748,Modify the molecule C[C@@H](CCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 by adding a amide.,C[C@@H](CCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1,amide
166378,Add a amide to the molecule C[S@@](=O)c1ccc(C(=O)N(Cc2ccco2)CC(F)(F)F)cc1.,C[S@@](=O)c1ccc(C(=O)N(Cc2ccco2)CC(F)(F)F)cc1,amide
129148,Please add a benzene ring to the molecule C[C@@H](NC(=S)NNC(=O)c1ccc2c(c1)CCCC2)C1CC1.,C[C@@H](NC(=S)NNC(=O)c1ccc2c(c1)CCCC2)C1CC1,benzene ring
163941,Modify the molecule CCOC[C@H]1CCCN(C(=O)c2csc(COC)n2)C1 by adding a aldehyde.,CCOC[C@H]1CCCN(C(=O)c2csc(COC)n2)C1,aldehyde
243823,Please add a nitrile to the molecule NC(=O)CSc1nnc(-c2ccco2)n1Cc1ccco1.,NC(=O)CSc1nnc(-c2ccco2)n1Cc1ccco1,nitrile
220496,Please add a aldehyde to the molecule CS(=O)(=O)N1CCCn2nc(CNc3ncccn3)cc2C1.,CS(=O)(=O)N1CCCn2nc(CNc3ncccn3)cc2C1,aldehyde
225766,Add a benzene ring to the molecule CC[C@H](CSC)N(C)C(=O)c1cccc(C)c1F.,CC[C@H](CSC)N(C)C(=O)c1cccc(C)c1F,benzene ring
84218,Modify the molecule COc1ccc([C@@H](O)[C@H](C)[NH2+][C@H](C)CC(=O)N2CCOCC2)cc1 by adding a hydroxyl.,COc1ccc([C@@H](O)[C@H](C)[NH2+][C@H](C)CC(=O)N2CCOCC2)cc1,hydroxyl
31086,Add a carboxyl to the molecule C[C@@H]1CCCC[C@H]1NC(=O)CN1CCO[C@H](CC(=O)[O-])C1.,C[C@@H]1CCCC[C@H]1NC(=O)CN1CCO[C@H](CC(=O)[O-])C1,carboxyl
75040,Modify the molecule CC(C)N(C)C(=O)/C=C/c1cn(-c2ccccc2)nc1-c1cccnc1 by adding a benzene ring.,CC(C)N(C)C(=O)/C=C/c1cn(-c2ccccc2)nc1-c1cccnc1,benzene ring
103507,Modify the molecule CN(C)c1cccc(CNC(=O)NC2CC[NH+](C[C@H]3CCOC3)CC2)c1 by adding a halo.,CN(C)c1cccc(CNC(=O)NC2CC[NH+](C[C@H]3CCOC3)CC2)c1,halo
227053,Modify the molecule Cc1ccc(C[NH+](CC(=O)NCC(=O)N2CCCC2)C(C)C)s1 by adding a hydroxyl.,Cc1ccc(C[NH+](CC(=O)NCC(=O)N2CCCC2)C(C)C)s1,hydroxyl
93556,Please add a amide to the molecule COC(=O)NCCOC(=O)c1ccc(C(F)(F)F)nc1.,COC(=O)NCCOC(=O)c1ccc(C(F)(F)F)nc1,amide
125609,Add a amine to the molecule CCCO[C@@H]1CCC[NH+](CC2(CS)CCCCC2)C1.,CCCO[C@@H]1CCC[NH+](CC2(CS)CCCCC2)C1,amine
91738,Modify the molecule CC(=O)Nc1ccc(S(=O)(=O)N2CCOc3ccc(C(=O)NCc4ccccc4F)cc3C2)cc1 by adding a hydroxyl.,CC(=O)Nc1ccc(S(=O)(=O)N2CCOc3ccc(C(=O)NCc4ccccc4F)cc3C2)cc1,hydroxyl
103409,Add a benzene ring to the molecule [NH3+]C[C@H]1CCCC[C@H]1N1C(=O)CCCC1=O.,[NH3+]C[C@H]1CCCC[C@H]1N1C(=O)CCCC1=O,benzene ring
176641,Modify the molecule CCOc1ccccc1C(=O)N[C@@H](C)c1ccccc1Br by adding a hydroxyl.,CCOc1ccccc1C(=O)N[C@@H](C)c1ccccc1Br,hydroxyl
98349,Add a amide to the molecule CC[C@@H](OC(=O)c1ccc(F)nc1)c1cccc([N+](=O)[O-])c1.,CC[C@@H](OC(=O)c1ccc(F)nc1)c1cccc([N+](=O)[O-])c1,amide
55295,Add a halo to the molecule CCOc1ccc(C(=O)CN2C(=O)N[C@@]3(CCCC[C@@H]3C)C2=O)cc1.,CCOc1ccc(C(=O)CN2C(=O)N[C@@]3(CCCC[C@@H]3C)C2=O)cc1,halo
51548,Modify the molecule CN(C)c1ccccc1NC(=O)NC[C@@H](O)c1c(F)cccc1F by adding a nitro.,CN(C)c1ccccc1NC(=O)NC[C@@H](O)c1c(F)cccc1F,nitro
6493,Add a benzene ring to the molecule C#CCOC(=O)C1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1.,C#CCOC(=O)C1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1,benzene ring
185609,Modify the molecule COc1ccc(CCCC(=O)N2C[C@@H](C(N)=O)CC[C@H]2C)cc1F by adding a benzene ring.,COc1ccc(CCCC(=O)N2C[C@@H](C(N)=O)CC[C@H]2C)cc1F,benzene ring
193822,Add a hydroxyl to the molecule O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1.,O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1,hydroxyl
210402,Modify the molecule CN(C)C(=O)[C@H]([NH3+])Cc1ccccc1 by adding a amide.,CN(C)C(=O)[C@H]([NH3+])Cc1ccccc1,amide
226788,Add a benzene ring to the molecule CCn1nc(C(=O)N[C@@H](c2cccs2)C(C)C)c2ccccc2c1=O.,CCn1nc(C(=O)N[C@@H](c2cccs2)C(C)C)c2ccccc2c1=O,benzene ring
80928,Modify the molecule CC(C)S(=O)(=O)Cc1ccc(NC(=O)N2CCC(Cc3[nH+]ccn3C)CC2)cc1 by adding a halo.,CC(C)S(=O)(=O)Cc1ccc(NC(=O)N2CCC(Cc3[nH+]ccn3C)CC2)cc1,halo
221610,Add a carboxyl to the molecule COc1ccc(CNC(=O)C(=O)Nc2ccc(C(C)C)cc2)cc1OC.,COc1ccc(CNC(=O)C(=O)Nc2ccc(C(C)C)cc2)cc1OC,carboxyl
82716,Please add a amine to the molecule Cc1sc(N2CCCCC2)[s+]c1SCC(=O)[O-].,Cc1sc(N2CCCCC2)[s+]c1SCC(=O)[O-],amine
107764,Add a amide to the molecule COc1ccc([C@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)c(OCc2ccccc2)c1.,COc1ccc([C@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)c(OCc2ccccc2)c1,amide
118723,Add a thiol to the molecule CO[C@H](C)c1noc(CC[C@@H](C)CC[NH3+])n1.,CO[C@H](C)c1noc(CC[C@@H](C)CC[NH3+])n1,thiol
248212,Add a benzene ring to the molecule CC[NH+](CC)C[C@H]1CCN(C(=O)c2ccc(Br)c(F)c2)C1.,CC[NH+](CC)C[C@H]1CCN(C(=O)c2ccc(Br)c(F)c2)C1,benzene ring
75377,Modify the molecule Cc1ccccc1C1(CNC(=O)NCCc2ccccn2)CC1 by adding a hydroxyl.,Cc1ccccc1C1(CNC(=O)NCCc2ccccn2)CC1,hydroxyl
71485,Modify the molecule C[C@@H](Cn1cc[nH+]c1)NC(=O)N1CCO[C@@H](c2ccc(F)cc2)C1 by adding a benzene ring.,C[C@@H](Cn1cc[nH+]c1)NC(=O)N1CCO[C@@H](c2ccc(F)cc2)C1,benzene ring
191061,Please add a benzene ring to the molecule Cc1[nH]ncc1C(=O)N[C@H](C)c1nc(-c2ccc(Cl)cc2)no1.,Cc1[nH]ncc1C(=O)N[C@H](C)c1nc(-c2ccc(Cl)cc2)no1,benzene ring
194572,Modify the molecule Cc1ccc(N2CCC[C@@H]([NH+]3CCC(CN4CCOCC4)CC3)C2=O)cc1 by adding a hydroxyl.,Cc1ccc(N2CCC[C@@H]([NH+]3CCC(CN4CCOCC4)CC3)C2=O)cc1,hydroxyl
242576,Please add a benzene ring to the molecule CC[C@@H](C)CN(CC)[C@@H](C[NH3+])c1cccc(Cl)c1Cl.,CC[C@@H](C)CN(CC)[C@@H](C[NH3+])c1cccc(Cl)c1Cl,benzene ring
212680,Modify the molecule CN(C(=O)c1ccc(-n2cncn2)cc1)c1cc(Cl)cc(Cl)c1 by adding a benzene ring.,CN(C(=O)c1ccc(-n2cncn2)cc1)c1cc(Cl)cc(Cl)c1,benzene ring
76572,Please add a nitro to the molecule C[C@H](NC(=O)CCc1ncc(-c2c(F)cccc2F)o1)C1CC1.,C[C@H](NC(=O)CCc1ncc(-c2c(F)cccc2F)o1)C1CC1,nitro
77972,Add a aldehyde to the molecule NC(=O)[C@H]1CCN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)c2ccccc21.,NC(=O)[C@H]1CCN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)c2ccccc21,aldehyde
164629,Add a nitro to the molecule Cc1n[nH]cc1CNC1(c2ccc(F)cc2F)CCOCC1.,Cc1n[nH]cc1CNC1(c2ccc(F)cc2F)CCOCC1,nitro
182474,Modify the molecule Nc1nc(C[NH+]2CCCCCCC2)nc2ccccc12 by adding a benzene ring.,Nc1nc(C[NH+]2CCCCCCC2)nc2ccccc12,benzene ring
140312,Add a nitro to the molecule O=C(CS(=O)(=O)Cc1cccc(Br)c1)N[C@H](c1ccccc1)c1ccc(F)cc1.,O=C(CS(=O)(=O)Cc1cccc(Br)c1)N[C@H](c1ccccc1)c1ccc(F)cc1,nitro
105773,Modify the molecule N#CCCNC(=O)[C@H]1C[C@H](O)C[NH2+]1 by adding a benzene ring.,N#CCCNC(=O)[C@H]1C[C@H](O)C[NH2+]1,benzene ring
59700,Please add a benzene ring to the molecule CC(C)(C)C1=C[C@@H]([C@H]2CC(=O)NC[C@H]3N=C4C=CC=CN4[C@H]23)N=N1.,CC(C)(C)C1=C[C@@H]([C@H]2CC(=O)NC[C@H]3N=C4C=CC=CN4[C@H]23)N=N1,benzene ring
115764,Add a nitro to the molecule Cc1cc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)on1.,Cc1cc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)on1,nitro
236337,Please add a amine to the molecule CCCCn1nc(C)c2c(C(=O)N[C@@H](C)c3cnn(C)c3C)cc(C3CC3)nc21.,CCCCn1nc(C)c2c(C(=O)N[C@@H](C)c3cnn(C)c3C)cc(C3CC3)nc21,amine
162924,Please add a amide to the molecule Cc1ccc(N2C(=O)c3oc4ccc(F)cc4c(=O)c3[C@@H]2c2cccc(OCCC(C)C)c2)nc1.,Cc1ccc(N2C(=O)c3oc4ccc(F)cc4c(=O)c3[C@@H]2c2cccc(OCCC(C)C)c2)nc1,amide
138794,Add a hydroxyl to the molecule O=C(CCN1C(=O)/C(=C/c2ccccc2F)SC1=S)N[C@@H]1CSC[C@@H]1O.,O=C(CCN1C(=O)/C(=C/c2ccccc2F)SC1=S)N[C@@H]1CSC[C@@H]1O,hydroxyl
179763,Modify the molecule Cc1nn2c(c1-c1ccccc1)NC1=C(C(=O)C[C@H](C)C1)[C@@H]2c1ccccc1[N+](=O)[O-] by adding a amide.,Cc1nn2c(c1-c1ccccc1)NC1=C(C(=O)C[C@H](C)C1)[C@@H]2c1ccccc1[N+](=O)[O-],amide
201446,Add a amide to the molecule COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(C)cc3C)n[nH]2)CC1.,COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(C)cc3C)n[nH]2)CC1,amide
204592,Please add a amine to the molecule CCN1CC2(CCC1=O)CC[NH+](Cc1nc(C(F)(F)F)no1)CC2.,CCN1CC2(CCC1=O)CC[NH+](Cc1nc(C(F)(F)F)no1)CC2,amine
98069,Modify the molecule N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1 by adding a carboxyl.,N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1,carboxyl
31210,Modify the molecule CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1 by adding a halo.,CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1,halo
78932,Please add a halo to the molecule CCn1c(C(=O)NC(C)(C)c2ncc(C)s2)cc2ccccc21.,CCn1c(C(=O)NC(C)(C)c2ncc(C)s2)cc2ccccc21,halo
13910,Add a hydroxyl to the molecule Cc1n[nH]c(C)c1CCC(=O)N(C)Cc1csc2ccccc12.,Cc1n[nH]c(C)c1CCC(=O)N(C)Cc1csc2ccccc12,hydroxyl
60059,Modify the molecule Cc1ccc([C@H]([NH3+])c2n[nH]c(COc3ccc(C(C)(C)C)cc3)n2)cc1 by adding a nitrile.,Cc1ccc([C@H]([NH3+])c2n[nH]c(COc3ccc(C(C)(C)C)cc3)n2)cc1,nitrile
151492,Modify the molecule NC(=O)N1CCC([NH+]2CCC[C@@H]2c2cccc3c2OCCO3)CC1 by adding a amine.,NC(=O)N1CCC([NH+]2CCC[C@@H]2c2cccc3c2OCCO3)CC1,amine
128954,Modify the molecule O=C(c1cc(Cl)cc([N+](=O)[O-])c1)N1CCOC[C@@H]1CCO by adding a aldehyde.,O=C(c1cc(Cl)cc([N+](=O)[O-])c1)N1CCOC[C@@H]1CCO,aldehyde
153449,Please add a halo to the molecule Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F.,Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F,halo
191806,Please add a amine to the molecule C[C@H]1SCCC[C@@]1(C[NH3+])N1CC[NH+](CC2CC2)CC1.,C[C@H]1SCCC[C@@]1(C[NH3+])N1CC[NH+](CC2CC2)CC1,amine
154084,Please add a nitro to the molecule O=C(c1ccc(-c2nnco2)cc1)N1CCC[C@H]1c1nc2ccccc2s1.,O=C(c1ccc(-c2nnco2)cc1)N1CCC[C@H]1c1nc2ccccc2s1,nitro
60821,Modify the molecule O=C(CCN1C(=O)c2ccccc2C1=O)Nc1cc(Cl)ccc1Oc1ccccc1 by adding a amide.,O=C(CCN1C(=O)c2ccccc2C1=O)Nc1cc(Cl)ccc1Oc1ccccc1,amide
161566,Please add a carboxyl to the molecule C[C@@H]1C[NH2+][C@H](c2cc(F)cc(F)c2)CS1.,C[C@@H]1C[NH2+][C@H](c2cc(F)cc(F)c2)CS1,carboxyl
216795,Add a amide to the molecule Fc1cc(NC(=S)NC2CC2)ccc1N1CCCC1.,Fc1cc(NC(=S)NC2CC2)ccc1N1CCCC1,amide
202193,Modify the molecule Cc1cc(/C=C2\C(=O)N(Cc3ccco3)C(=O)N=C2[O-])c(C)n1-c1ccc(Cl)c(C(=O)[O-])c1 by adding a nitro.,Cc1cc(/C=C2\C(=O)N(Cc3ccco3)C(=O)N=C2[O-])c(C)n1-c1ccc(Cl)c(C(=O)[O-])c1,nitro
58683,Please add a benzene ring to the molecule CS(=O)(=O)c1cccc(NCCc2ccc(F)cc2)c1[N+](=O)[O-].,CS(=O)(=O)c1cccc(NCCc2ccc(F)cc2)c1[N+](=O)[O-],benzene ring
187072,Add a hydroxyl to the molecule CC[NH+](CC)CCN1C(N)=[NH+]C[C@@]12CC[C@H](C)[C@H](C)C2.,CC[NH+](CC)CCN1C(N)=[NH+]C[C@@]12CC[C@H](C)[C@H](C)C2,hydroxyl
242620,Modify the molecule COc1cccc(-c2nnc(CCC(=O)N3CCC(Cc4ccccc4)CC3)c([O-])n2)c1 by adding a benzene ring.,COc1cccc(-c2nnc(CCC(=O)N3CCC(Cc4ccccc4)CC3)c([O-])n2)c1,benzene ring
182546,Please add a benzene ring to the molecule C[C@@H](c1ccccc1)N(C)C(=O)CC1(O)CCCCC1.,C[C@@H](c1ccccc1)N(C)C(=O)CC1(O)CCCCC1,benzene ring
126543,Modify the molecule CC1(C)NC(=O)N(CC[NH+]2CCC(C(=O)N3CCCC3)CC2)C1=O by adding a amine.,CC1(C)NC(=O)N(CC[NH+]2CCC(C(=O)N3CCCC3)CC2)C1=O,amine
30307,Modify the molecule Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)nnn1-c1ccc(C(C)C)cc1 by adding a halo.,Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)nnn1-c1ccc(C(C)C)cc1,halo
112736,Add a benzene ring to the molecule O=C(CSc1nnnn1Cc1cccs1)c1c[nH]c(C(=O)N2CCCC2)c1.,O=C(CSc1nnnn1Cc1cccs1)c1c[nH]c(C(=O)N2CCCC2)c1,benzene ring
132204,Modify the molecule CN1C[C@H](C(=O)N2CCNC(=O)C2)CC1=O by adding a hydroxyl.,CN1C[C@H](C(=O)N2CCNC(=O)C2)CC1=O,hydroxyl
230977,Modify the molecule O=C(NC[C@H](c1ccc(C(F)(F)F)cc1)N1CCOCC1)[C@@H]1COc2ccccc21 by adding a thiol.,O=C(NC[C@H](c1ccc(C(F)(F)F)cc1)N1CCOCC1)[C@@H]1COc2ccccc21,thiol
138465,Modify the molecule CC(C)(C)C[C@@H]1CCCN1C(=O)NCc1ccc(CN2CCCC2=O)cc1 by adding a hydroxyl.,CC(C)(C)C[C@@H]1CCCN1C(=O)NCc1ccc(CN2CCCC2=O)cc1,hydroxyl
133722,Add a halo to the molecule Cc1cccnc1[C@@H]([NH2+][C@@H](C)c1ccc(F)cn1)C(C)C.,Cc1cccnc1[C@@H]([NH2+][C@@H](C)c1ccc(F)cn1)C(C)C,halo
98390,Please add a amide to the molecule Cc1ccccc1CNC(=O)NC1CCC(Oc2ccc(C#N)cn2)CC1.,Cc1ccccc1CNC(=O)NC1CCC(Oc2ccc(C#N)cn2)CC1,amide
2556,Modify the molecule CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] by adding a benzene ring.,CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-],benzene ring
141082,Modify the molecule COc1ccc(NC(=O)CC[C@@H]2CCCN(C(=O)c3sccc3C)C2)cc1Cl by adding a halo.,COc1ccc(NC(=O)CC[C@@H]2CCCN(C(=O)c3sccc3C)C2)cc1Cl,halo
134701,Please add a amide to the molecule Nc1c(C(=O)NCCc2ccccc2)nnn1-c1ccc(F)cc1.,Nc1c(C(=O)NCCc2ccccc2)nnn1-c1ccc(F)cc1,amide
125670,Modify the molecule CC(=O)Nc1ccc(C)c(NC(=O)Cc2ccc[nH]2)c1 by adding a amine.,CC(=O)Nc1ccc(C)c(NC(=O)Cc2ccc[nH]2)c1,amine
109364,Please add a aldehyde to the molecule C#CCn1/c(=N/C(=O)CCC)sc2cc(OC)c(OC)cc21.,C#CCn1/c(=N/C(=O)CCC)sc2cc(OC)c(OC)cc21,aldehyde
182329,Please add a halo to the molecule O=C(c1cc(Br)ccc1Cl)N1CCC(Cn2cc[nH+]c2)CC1.,O=C(c1cc(Br)ccc1Cl)N1CCC(Cn2cc[nH+]c2)CC1,halo
20919,Please add a hydroxyl to the molecule Cc1ccc(NC(=O)CSCc2cc(=O)n3nc(C4CCCCC4)sc3n2)cc1.,Cc1ccc(NC(=O)CSCc2cc(=O)n3nc(C4CCCCC4)sc3n2)cc1,hydroxyl
105204,Add a carboxyl to the molecule CCOC(=O)[C@@H]1[C@@H]2C(=O)N(c3ccccc3Cl)C[C@]23C=C[C@H]1O3.,CCOC(=O)[C@@H]1[C@@H]2C(=O)N(c3ccccc3Cl)C[C@]23C=C[C@H]1O3,carboxyl
100866,Modify the molecule COc1cc([C@H](C)[C@@H](C)Br)ccc1Cl by adding a amide.,COc1cc([C@H](C)[C@@H](C)Br)ccc1Cl,amide
70439,Modify the molecule O=S(=O)(NCCCn1ccnc1)c1cnn(-c2ccccc2)c1 by adding a benzene ring.,O=S(=O)(NCCCn1ccnc1)c1cnn(-c2ccccc2)c1,benzene ring
97490,Please add a hydroxyl to the molecule C[C@@H]1[NH2+]CC[C@H]1C(=O)N1CCC[C@@H]1c1ccncc1.,C[C@@H]1[NH2+]CC[C@H]1C(=O)N1CCC[C@@H]1c1ccncc1,hydroxyl
230046,Modify the molecule C[C@H](C[NH3+])Sc1ccncc1 by adding a benzene ring.,C[C@H](C[NH3+])Sc1ccncc1,benzene ring
220671,Add a amide to the molecule CCS(=O)(=O)CCN(C)C(=O)/C=C/c1nc2ccccc2o1.,CCS(=O)(=O)CCN(C)C(=O)/C=C/c1nc2ccccc2o1,amide
121160,Please add a aldehyde to the molecule Cc1cccc(C(N)=O)c1NCc1cn2cccc(C)c2[nH+]1.,Cc1cccc(C(N)=O)c1NCc1cn2cccc(C)c2[nH+]1,aldehyde
53615,Modify the molecule CCCN(C)c1c(C[NH2+]CC)c(C)nn1C by adding a nitro.,CCCN(C)c1c(C[NH2+]CC)c(C)nn1C,nitro
193339,Please add a carboxyl to the molecule [O-]c1nc(SCC2[NH+]=c3ccccc3=[NH+]2)nc2nc[nH]c12.,[O-]c1nc(SCC2[NH+]=c3ccccc3=[NH+]2)nc2nc[nH]c12,carboxyl
144828,Add a amide to the molecule O=C1N[C@@H](O)c2cc(Br)ccc21.,O=C1N[C@@H](O)c2cc(Br)ccc21,amide
221552,Please add a hydroxyl to the molecule C[C@H](NC(=O)NCC1CC[NH+](C)CC1)c1cccc(-n2ccnc2)c1.,C[C@H](NC(=O)NCC1CC[NH+](C)CC1)c1cccc(-n2ccnc2)c1,hydroxyl
154490,Please add a hydroxyl to the molecule O=C(NC[C@@H](O)COc1ccc(F)cc1)NC[C@H]1Cc2ccccc2O1.,O=C(NC[C@@H](O)COc1ccc(F)cc1)NC[C@H]1Cc2ccccc2O1,hydroxyl
176805,Please add a amide to the molecule COc1ccc(Cn2nnnc2[C@@H](c2cc3cccc(C)c3[nH]c2=O)N2CCOCC2)cc1.,COc1ccc(Cn2nnnc2[C@@H](c2cc3cccc(C)c3[nH]c2=O)N2CCOCC2)cc1,amide
128213,Please add a carboxyl to the molecule CC[NH2+][C@H](c1ccc(SC)cc1)c1ccc(OC)c(Br)c1.,CC[NH2+][C@H](c1ccc(SC)cc1)c1ccc(OC)c(Br)c1,carboxyl
115239,Please add a amide to the molecule CCNS(=O)(=O)[C@H]1CC[NH+](CC(=O)Nc2cc(C)on2)C1.,CCNS(=O)(=O)[C@H]1CC[NH+](CC(=O)Nc2cc(C)on2)C1,amide
142156,Modify the molecule O=C(CCC1=c2ccccc2=[NH+][C@@H]1c1ccc(F)cc1)N1CCN(c2ccccc2O)CC1 by adding a carboxyl.,O=C(CCC1=c2ccccc2=[NH+][C@@H]1c1ccc(F)cc1)N1CCN(c2ccccc2O)CC1,carboxyl
193461,Add a benzene ring to the molecule COc1ccc(-c2cn3nc(SCC(=O)Nc4ccc5c(c4)OCCO5)ccc3n2)cc1.,COc1ccc(-c2cn3nc(SCC(=O)Nc4ccc5c(c4)OCCO5)ccc3n2)cc1,benzene ring
135434,Add a carboxyl to the molecule C[C@H](OC(=O)c1ccc(Br)cc1F)[C@H]1CCOC1.,C[C@H](OC(=O)c1ccc(Br)cc1F)[C@H]1CCOC1,carboxyl
8957,Modify the molecule C[C@H](O)[C@@H](C)SCC(=O)Nc1ccc(OC(F)(F)F)cc1 by adding a carboxyl.,C[C@H](O)[C@@H](C)SCC(=O)Nc1ccc(OC(F)(F)F)cc1,carboxyl
21660,Please add a nitro to the molecule [NH3+]C[C@H]1CCC[C@@H]1NC(=O)C[C@H]1CCCCO1.,[NH3+]C[C@H]1CCC[C@@H]1NC(=O)C[C@H]1CCCCO1,nitro
222489,Modify the molecule CCCCCN(Cc1ccc(Cl)cc1)S(C)(=O)=O by adding a amide.,CCCCCN(Cc1ccc(Cl)cc1)S(C)(=O)=O,amide
151945,Please add a hydroxyl to the molecule C[C@H](NC(=O)c1ccco1)C(=O)Nc1ccc(C(N)=O)c(Cl)c1.,C[C@H](NC(=O)c1ccco1)C(=O)Nc1ccc(C(N)=O)c(Cl)c1,hydroxyl
174193,Please add a hydroxyl to the molecule Cc1ccc(OCc2nc(CC(=O)N3C[C@@H](C)CC[C@@H]3C)cs2)cc1.,Cc1ccc(OCc2nc(CC(=O)N3C[C@@H](C)CC[C@@H]3C)cs2)cc1,hydroxyl
175910,Add a hydroxyl to the molecule C/C(=N\Nc1cccc([N+](=O)[O-])c1)c1ccc(O)cc1.,C/C(=N\Nc1cccc([N+](=O)[O-])c1)c1ccc(O)cc1,hydroxyl
116551,Please add a amide to the molecule Cc1n[nH]c(-c2ccc(C(=O)NCC(=O)N3CCCC3)cc2)n1.,Cc1n[nH]c(-c2ccc(C(=O)NCC(=O)N3CCCC3)cc2)n1,amide
55827,Add a amine to the molecule CC(C)[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NCCc1cn2ccccc2n1.,CC(C)[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NCCc1cn2ccccc2n1,amine
107721,Please add a amine to the molecule CC(C)c1ccc(CNc2cnn(-c3ccccc3S(C)(=O)=O)c2)cc1.,CC(C)c1ccc(CNc2cnn(-c3ccccc3S(C)(=O)=O)c2)cc1,amine
105336,Add a benzene ring to the molecule Cc1cscc1-c1noc(-c2cc(Cl)cc(Cl)c2N)n1.,Cc1cscc1-c1noc(-c2cc(Cl)cc(Cl)c2N)n1,benzene ring
4604,Add a hydroxyl to the molecule COc1ccc(CNC(=O)Cn2ncc3c(C)n(Cc4ccccc4F)c(C)c3c2=O)cc1.,COc1ccc(CNC(=O)Cn2ncc3c(C)n(Cc4ccccc4F)c(C)c3c2=O)cc1,hydroxyl
43607,Add a benzene ring to the molecule CC[NH+]1CCN([C@H](C)CNC(=O)c2ccc(F)cc2Br)CC1.,CC[NH+]1CCN([C@H](C)CNC(=O)c2ccc(F)cc2Br)CC1,benzene ring
199772,Add a aldehyde to the molecule C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(OC(F)F)c2)C1.,C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(OC(F)F)c2)C1,aldehyde
68583,Please add a aldehyde to the molecule Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O.,Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O,aldehyde
94876,Please add a amine to the molecule O=C(CCc1csc2nc(-c3ccccc3)cn12)Nc1ccc(Cl)cc1.,O=C(CCc1csc2nc(-c3ccccc3)cn12)Nc1ccc(Cl)cc1,amine
214527,Modify the molecule NC(=O)COc1cccc([C@@H]2CC(=O)N[C@@H]3[C@H]2C([O-])=Nc2nc4ccccc4n23)c1 by adding a amide.,NC(=O)COc1cccc([C@@H]2CC(=O)N[C@@H]3[C@H]2C([O-])=Nc2nc4ccccc4n23)c1,amide
212286,Please add a benzene ring to the molecule Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12.,Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12,benzene ring
130258,Please add a benzene ring to the molecule C[C@@H]1CCc2c(sc3nc(CN(C)CCS(C)(=O)=O)nc(N)c23)C1.,C[C@@H]1CCc2c(sc3nc(CN(C)CCS(C)(=O)=O)nc(N)c23)C1,benzene ring
119483,Modify the molecule CC(C)NC(=O)N1CCc2nc(NC(=O)NC3CCCC3)sc2C1 by adding a nitro.,CC(C)NC(=O)N1CCc2nc(NC(=O)NC3CCCC3)sc2C1,nitro
113617,Add a halo to the molecule CNC(=O)NCC(=O)N1CCC[C@H]1Cc1ccc(C)cc1.,CNC(=O)NCC(=O)N1CCC[C@H]1Cc1ccc(C)cc1,halo
47202,Add a hydroxyl to the molecule O=C(COc1ccc(F)cc1)NCc1ccc(N2CCOCC2)c(F)c1.,O=C(COc1ccc(F)cc1)NCc1ccc(N2CCOCC2)c(F)c1,hydroxyl
129999,Please add a aldehyde to the molecule Cc1sc2ncn(CC(=O)Nc3nc(-c4ccc(Br)cc4)cs3)c(=O)c2c1C.,Cc1sc2ncn(CC(=O)Nc3nc(-c4ccc(Br)cc4)cs3)c(=O)c2c1C,aldehyde
191487,Please add a amine to the molecule CCc1noc(C)c1C(=O)N(C)C1(C(=O)OC)CCCCC1.,CCc1noc(C)c1C(=O)N(C)C1(C(=O)OC)CCCCC1,amine
196524,Please add a hydroxyl to the molecule Cc1nn(C2CCCCC2)c(C)c1C[C@@H](C)C[NH2+]C1CC1.,Cc1nn(C2CCCCC2)c(C)c1C[C@@H](C)C[NH2+]C1CC1,hydroxyl
156267,Modify the molecule C=CCN1C(=O)[C@@H](CC(=O)Nc2ccc(Cl)cc2)S/C1=N\c1ccc(F)cc1 by adding a nitro.,C=CCN1C(=O)[C@@H](CC(=O)Nc2ccc(Cl)cc2)S/C1=N\c1ccc(F)cc1,nitro
130753,Modify the molecule COc1cccc(CC(=O)NCc2ccc[nH+]c2N(C)C)c1 by adding a hydroxyl.,COc1cccc(CC(=O)NCc2ccc[nH+]c2N(C)C)c1,hydroxyl
13868,Modify the molecule COc1cn(-c2ccccc2)nc1C(=O)N(C)[C@@H](C)c1ccc(F)cc1 by adding a hydroxyl.,COc1cn(-c2ccccc2)nc1C(=O)N(C)[C@@H](C)c1ccc(F)cc1,hydroxyl
208706,Modify the molecule C[NH2+][C@H](C)c1cccn1CCn1cccn1 by adding a amide.,C[NH2+][C@H](C)c1cccn1CCn1cccn1,amide
167048,Please add a hydroxyl to the molecule C[NH2+][C@@H](C1CC1)C1(N2CCOCC2)CCCC1.,C[NH2+][C@@H](C1CC1)C1(N2CCOCC2)CCCC1,hydroxyl
38862,Modify the molecule CC1=NN(C(=O)[C@@H](CC(C)C)NC(=O)c2ccccc2)[C@@](C)(O)C1 by adding a aldehyde.,CC1=NN(C(=O)[C@@H](CC(C)C)NC(=O)c2ccccc2)[C@@](C)(O)C1,aldehyde
41658,Add a hydroxyl to the molecule CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1.,CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1,hydroxyl
153703,Please add a hydroxyl to the molecule CC[C@H](C(=O)Nc1ccc2[nH]nc(C(=O)OC)c2c1)c1ccccc1.,CC[C@H](C(=O)Nc1ccc2[nH]nc(C(=O)OC)c2c1)c1ccccc1,hydroxyl
193304,Please add a amide to the molecule C[C@@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)NC[C@@H](C)c1cccs1.,C[C@@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)NC[C@@H](C)c1cccs1,amide
148351,Please add a hydroxyl to the molecule Cc1c(C(=O)NCC2CCN(c3cc[nH+]cc3)CC2)cnn1C(C)C.,Cc1c(C(=O)NCC2CCN(c3cc[nH+]cc3)CC2)cnn1C(C)C,hydroxyl
227219,Modify the molecule CC[C@H](C)C[NH+](C)C[C@@H]1CCCC(C)(C)C1=O by adding a carboxyl.,CC[C@H](C)C[NH+](C)C[C@@H]1CCCC(C)(C)C1=O,carboxyl
202184,Modify the molecule O=C(NCCOc1cccc(C(F)(F)F)c1)N[C@H]1CCC[C@@H]1CO by adding a benzene ring.,O=C(NCCOc1cccc(C(F)(F)F)c1)N[C@H]1CCC[C@@H]1CO,benzene ring
143477,Modify the molecule CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O by adding a amide.,CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O,amide
195561,Add a hydroxyl to the molecule CS[C@H]1CC[C@@H](NC(=O)c2cc3ccccc3oc2=O)C1.,CS[C@H]1CC[C@@H](NC(=O)c2cc3ccccc3oc2=O)C1,hydroxyl
135595,Add a hydroxyl to the molecule C=CCn1c(=O)c2c(nc(N/N=C/c3cccc(OC)c3)n2C)n(C)c1=O.,C=CCn1c(=O)c2c(nc(N/N=C/c3cccc(OC)c3)n2C)n(C)c1=O,hydroxyl
63076,Modify the molecule CC(C)(C)OC(=O)NCc1ccccc1[C@@H]1CCC[NH2+]C1 by adding a hydroxyl.,CC(C)(C)OC(=O)NCc1ccccc1[C@@H]1CCC[NH2+]C1,hydroxyl
38063,Modify the molecule Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1 by adding a benzene ring.,Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1,benzene ring
96317,Modify the molecule Cc1cc(Br)ccc1C(=O)Nc1ccc2c(c1)COC2 by adding a amide.,Cc1cc(Br)ccc1C(=O)Nc1ccc2c(c1)COC2,amide
46155,Please add a hydroxyl to the molecule Cc1ccc([C@H](C[NH3+])CCOc2ccccc2)cc1.,Cc1ccc([C@H](C[NH3+])CCOc2ccccc2)cc1,hydroxyl
153530,Add a benzene ring to the molecule COC(=O)CNC(=O)C1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1.,COC(=O)CNC(=O)C1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1,benzene ring
30498,Add a hydroxyl to the molecule COc1cccc(N2CCN(C(=O)C3CCN(c4ncnc5c4oc4ccccc45)CC3)CC2)c1.,COc1cccc(N2CCN(C(=O)C3CCN(c4ncnc5c4oc4ccccc45)CC3)CC2)c1,hydroxyl
65481,Add a amine to the molecule C[C@H]1CC[C@@H](C)C[NH+]1Cc1nnc(-c2ccc(C#N)cc2)o1.,C[C@H]1CC[C@@H](C)C[NH+]1Cc1nnc(-c2ccc(C#N)cc2)o1,amine
167467,Please add a benzene ring to the molecule Cc1ccc([C@H](NC(=O)Cn2cc(C(C)C)nn2)c2ccncc2)cc1C.,Cc1ccc([C@H](NC(=O)Cn2cc(C(C)C)nn2)c2ccncc2)cc1C,benzene ring
200228,Add a benzene ring to the molecule COC[C@H]1CCCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)C1.,COC[C@H]1CCCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)C1,benzene ring
49991,Modify the molecule Cc1ccc(CSCCNC(=O)NNC(=O)c2cccnc2)cc1 by adding a amide.,Cc1ccc(CSCCNC(=O)NNC(=O)c2cccnc2)cc1,amide
198408,Please add a benzene ring to the molecule CO[C@H]1CCC[C@@H](OC(=O)CCn2cnc3ccccc3c2=O)C1.,CO[C@H]1CCC[C@@H](OC(=O)CCn2cnc3ccccc3c2=O)C1,benzene ring
120136,Add a hydroxyl to the molecule CCOc1ccc([C@@H](C)NC(=O)Cn2ccnc2)cc1OC.,CCOc1ccc([C@@H](C)NC(=O)Cn2ccnc2)cc1OC,hydroxyl
50928,Modify the molecule Cc1c(N)cccc1S(=O)(=O)N[C@H]1CCC[C@@H](C)C1 by adding a hydroxyl.,Cc1c(N)cccc1S(=O)(=O)N[C@H]1CCC[C@@H](C)C1,hydroxyl
135948,Please add a halo to the molecule C[NH2+][C@H](C(C)C)[C@H]1CCO[C@H](C(C)C)C1.,C[NH2+][C@H](C(C)C)[C@H]1CCO[C@H](C(C)C)C1,halo
145363,Add a amide to the molecule Cc1cc2nc(Nc3nc4c(c(=O)[nH]3)CCCC4)nc(C)c2cc1C.,Cc1cc2nc(Nc3nc4c(c(=O)[nH]3)CCCC4)nc(C)c2cc1C,amide
193704,Modify the molecule CCCOC[C@@H]1CCN(C(=O)Cn2c(C)cc(=O)c3ccccc32)C1 by adding a aldehyde.,CCCOC[C@@H]1CCN(C(=O)Cn2c(C)cc(=O)c3ccccc32)C1,aldehyde
162189,Please add a hydroxyl to the molecule CNC(=O)COc1ccccc1CN1CCO[C@@H]2CC[C@@H](OC)C[C@@H]21.,CNC(=O)COc1ccccc1CN1CCO[C@@H]2CC[C@@H](OC)C[C@@H]21,hydroxyl
186528,Add a carboxyl to the molecule CC(C)c1ccc2c(c1)[C@]1(NC(=O)[C@H]3COCCN31)C(=O)N2.,CC(C)c1ccc2c(c1)[C@]1(NC(=O)[C@H]3COCCN31)C(=O)N2,carboxyl
201754,Modify the molecule COc1ccc(C[NH+](C)Cc2cccn2C)cc1C by adding a hydroxyl.,COc1ccc(C[NH+](C)Cc2cccn2C)cc1C,hydroxyl
51630,Please add a amide to the molecule CCOc1cc(F)ccc1NC(=O)c1cc(OC)cc(OC)c1.,CCOc1cc(F)ccc1NC(=O)c1cc(OC)cc(OC)c1,amide
139084,Please add a halo to the molecule O=C(NC[C@@H]1CCCS1(=O)=O)N[C@H](CO)c1ccc(Cl)cc1.,O=C(NC[C@@H]1CCCS1(=O)=O)N[C@H](CO)c1ccc(Cl)cc1,halo
130142,Modify the molecule O=C(Cc1csc(N2CCCC2=O)n1)N[C@@H]1CC[NH+]2CCCC[C@H]12 by adding a amide.,O=C(Cc1csc(N2CCCC2=O)n1)N[C@@H]1CC[NH+]2CCCC[C@H]12,amide
240506,Add a aldehyde to the molecule COc1ccccc1NC(=O)COc1ccc2ccccc2c1C=O.,COc1ccccc1NC(=O)COc1ccc2ccccc2c1C=O,aldehyde
76460,Modify the molecule Cc1cc(NC[C@@H](O)COc2ccc(F)c(F)c2)n2c(nc3ccccc32)c1C#N by adding a benzene ring.,Cc1cc(NC[C@@H](O)COc2ccc(F)c(F)c2)n2c(nc3ccccc32)c1C#N,benzene ring
159294,Please add a amide to the molecule C[C@@H]1CC[C@@]1(C[NH3+])c1cccc(Cl)c1.,C[C@@H]1CC[C@@]1(C[NH3+])c1cccc(Cl)c1,amide
141805,Modify the molecule Cc1ccc([C@H](CNC(=O)C(=O)Nc2cccc([N+](=O)[O-])c2)N2CC[NH+](C)CC2)cc1 by adding a thiol.,Cc1ccc([C@H](CNC(=O)C(=O)Nc2cccc([N+](=O)[O-])c2)N2CC[NH+](C)CC2)cc1,thiol
190755,Modify the molecule CNc1cc(C[NH+]2[C@@H](C)CCC[C@H]2C)ccc1[N+](=O)[O-] by adding a amide.,CNc1cc(C[NH+]2[C@@H](C)CCC[C@H]2C)ccc1[N+](=O)[O-],amide
196130,Please add a benzene ring to the molecule C[NH2+][C@H](C)c1ccc(N2CCC[C@H](C(N)=O)C2)c(F)c1.,C[NH2+][C@H](C)c1ccc(N2CCC[C@H](C(N)=O)C2)c(F)c1,benzene ring
234249,Modify the molecule CC(=O)NCc1ccc(S(=O)(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)s1 by adding a nitro.,CC(=O)NCc1ccc(S(=O)(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)s1,nitro
182244,Add a benzene ring to the molecule CCn1nc(C)c(NCc2cnc(-c3ccccn3)s2)c1C.,CCn1nc(C)c(NCc2cnc(-c3ccccn3)s2)c1C,benzene ring
42607,Please add a hydroxyl to the molecule C[NH+](C)C1(C(=O)Cc2ccc(C(C)(C)C)cc2)CCCC1.,C[NH+](C)C1(C(=O)Cc2ccc(C(C)(C)C)cc2)CCCC1,hydroxyl
2572,Modify the molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 by adding a amine.,CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1,amine
37108,Add a amide to the molecule O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1.,O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1,amide
37254,Add a benzene ring to the molecule C[C@@H](c1ccccc1F)N(C)C(=O)NC1CC1.,C[C@@H](c1ccccc1F)N(C)C(=O)NC1CC1,benzene ring
32740,Modify the molecule Cc1nc(CCCN2CCN(C3=[NH+]C[C@H](C)S3)CC2)cs1 by adding a hydroxyl.,Cc1nc(CCCN2CCN(C3=[NH+]C[C@H](C)S3)CC2)cs1,hydroxyl
235880,Add a nitro to the molecule CC(=O)Cc1nsc(NC(=O)c2ccccc2Br)n1.,CC(=O)Cc1nsc(NC(=O)c2ccccc2Br)n1,nitro
11028,Add a amide to the molecule CC(C)C(=O)Nc1ccccc1-c1ccccc1.,CC(C)C(=O)Nc1ccccc1-c1ccccc1,amide
88462,Modify the molecule Cc1ccc(Nc2ccc([N+](=O)[O-])ccc2=O)cc1 by adding a amide.,Cc1ccc(Nc2ccc([N+](=O)[O-])ccc2=O)cc1,amide
118272,Please add a aldehyde to the molecule COC[C@@H](C)Cc1nc(C[NH2+]C(C)C)no1.,COC[C@@H](C)Cc1nc(C[NH2+]C(C)C)no1,aldehyde
63372,Please add a thiol to the molecule CCC[C@]1(C)CN(Cc2ccccc2)CO1.,CCC[C@]1(C)CN(Cc2ccccc2)CO1,thiol
159954,Modify the molecule Cc1nc(C[NH2+]C/C=C/c2ccc(C#N)cc2)sc1C by adding a hydroxyl.,Cc1nc(C[NH2+]C/C=C/c2ccc(C#N)cc2)sc1C,hydroxyl
233046,Add a benzene ring to the molecule CS(=O)(=O)CCNc1nc(C[NH+]2CCCC2)nc2sc3c(c12)CCCC3.,CS(=O)(=O)CCNc1nc(C[NH+]2CCCC2)nc2sc3c(c12)CCCC3,benzene ring
185371,Modify the molecule C[C@@H]1CCC[C@@](O)([C@]2(C[NH3+])CCOC2)CC1 by adding a carboxyl.,C[C@@H]1CCC[C@@](O)([C@]2(C[NH3+])CCOC2)CC1,carboxyl
163922,Add a amine to the molecule O=C(CNC(=O)Cc1n[nH]c2c(Cl)cccc12)NCC1CCCCC1.,O=C(CNC(=O)Cc1n[nH]c2c(Cl)cccc12)NCC1CCCCC1,amine
123904,Please add a benzene ring to the molecule CC/C=C(/C)C(=O)N1C[C@@H](C)O[C@H](C)C1.,CC/C=C(/C)C(=O)N1C[C@@H](C)O[C@H](C)C1,benzene ring
98412,Modify the molecule CNC(=O)c1cc(S(=O)(=O)Nc2cc(C)ccc2O)cs1 by adding a benzene ring.,CNC(=O)c1cc(S(=O)(=O)Nc2cc(C)ccc2O)cs1,benzene ring
211901,Add a thiol to the molecule CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1.,CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1,thiol
170860,Modify the molecule Cc1ccc2sc(N3CC[NH+](CCNC(=O)c4ccc(Br)cc4)CC3)nc2c1C by adding a aldehyde.,Cc1ccc2sc(N3CC[NH+](CCNC(=O)c4ccc(Br)cc4)CC3)nc2c1C,aldehyde
191719,Add a amine to the molecule CS(=O)(=O)c1ccc([C@H](O)CN(Cc2ccccc2)C2CC2)cc1.,CS(=O)(=O)c1ccc([C@H](O)CN(Cc2ccccc2)C2CC2)cc1,amine
162282,Modify the molecule O=C(c1n[nH]c2ccc([N+](=O)[O-])cc12)N1CCC[C@@H]2CCCC[C@@H]21 by adding a benzene ring.,O=C(c1n[nH]c2ccc([N+](=O)[O-])cc12)N1CCC[C@@H]2CCCC[C@@H]21,benzene ring
17123,Modify the molecule Cc1noc(C)c1COc1cc2ccccc2cc1C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1 by adding a amide.,Cc1noc(C)c1COc1cc2ccccc2cc1C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1,amide
202679,Add a aldehyde to the molecule Cc1ccc(F)c(OCCCCCS)c1.,Cc1ccc(F)c(OCCCCCS)c1,aldehyde
77552,Add a hydroxyl to the molecule CC(C)[C@@H](NC(=O)[C@H]1C=C[C@@H]([NH3+])C1)c1cccs1.,CC(C)[C@@H](NC(=O)[C@H]1C=C[C@@H]([NH3+])C1)c1cccs1,hydroxyl
21019,Please add a amide to the molecule NC(=O)[C@H]1CCC[NH+](CCCNC(=O)Nc2cccc([N+](=O)[O-])c2)C1.,NC(=O)[C@H]1CCC[NH+](CCCNC(=O)Nc2cccc([N+](=O)[O-])c2)C1,amide
220581,Please add a amine to the molecule CCOc1cc(OC)ccc1C(=O)CN1C(=O)c2ccccc2O[C@@H](C)C1=O.,CCOc1cc(OC)ccc1C(=O)CN1C(=O)c2ccccc2O[C@@H](C)C1=O,amine
156415,Please add a hydroxyl to the molecule CC(=O)N[C@H]1C(=O)N(Cc2ccccc2Cl)c2ccccc21.,CC(=O)N[C@H]1C(=O)N(Cc2ccccc2Cl)c2ccccc21,hydroxyl
20536,Add a nitro to the molecule COc1cccc([C@H]2Nc3c(C(=O)N4CCOCC4)cccc3[C@@H]3C=CC[C@@H]23)c1O.,COc1cccc([C@H]2Nc3c(C(=O)N4CCOCC4)cccc3[C@@H]3C=CC[C@@H]23)c1O,nitro
101949,Please add a benzene ring to the molecule CC(=O)Nc1ccc(-c2csc(NC(=O)[C@H]3[C@H](C=C(C)C)C3(C)C)n2)cc1.,CC(=O)Nc1ccc(-c2csc(NC(=O)[C@H]3[C@H](C=C(C)C)C3(C)C)n2)cc1,benzene ring
191736,Add a benzene ring to the molecule O=c1ccc2cc(S(=O)(=O)NCCc3ccccc3)ccc2[nH]1.,O=c1ccc2cc(S(=O)(=O)NCCc3ccccc3)ccc2[nH]1,benzene ring
33833,Add a hydroxyl to the molecule [O-]c1c([C@@H](c2ccccc2)[NH+]2CCC(Cc3ccccc3)CC2)sc2ncnn12.,[O-]c1c([C@@H](c2ccccc2)[NH+]2CCC(Cc3ccccc3)CC2)sc2ncnn12,hydroxyl
54233,Please add a nitro to the molecule CNC(=O)c1ccc(CNC(=O)Cc2ccc(NC(=O)C3CC3)cc2)cc1.,CNC(=O)c1ccc(CNC(=O)Cc2ccc(NC(=O)C3CC3)cc2)cc1,nitro
7233,Add a hydroxyl to the molecule CN(Cc1cnn(C)c1)C(=O)C(=O)Nc1ccccc1Br.,CN(Cc1cnn(C)c1)C(=O)C(=O)Nc1ccccc1Br,hydroxyl
141040,Modify the molecule CCOCc1nc(N2CCOCC2)sc1C(=O)NCc1ccccc1 by adding a halo.,CCOCc1nc(N2CCOCC2)sc1C(=O)NCc1ccccc1,halo
58907,Modify the molecule CCOC(=O)C[NH+]1CCCN(Cc2cccs2)CC1 by adding a benzene ring.,CCOC(=O)C[NH+]1CCCN(Cc2cccs2)CC1,benzene ring
223688,Please add a amide to the molecule CC[C@H]1CN(c2ccc3nnnn3n2)[C@@H](CC)C[NH2+]1.,CC[C@H]1CN(c2ccc3nnnn3n2)[C@@H](CC)C[NH2+]1,amide
55222,Please add a aldehyde to the molecule Cn1c(CCN2CCOCC2)nc2cc(NC(=O)c3cccc([N+](=O)[O-])c3)ccc21.,Cn1c(CCN2CCOCC2)nc2cc(NC(=O)c3cccc([N+](=O)[O-])c3)ccc21,aldehyde
51696,Add a carboxyl to the molecule CN(C)c1n[nH]c(=O)c2ccccc12.,CN(C)c1n[nH]c(=O)c2ccccc12,carboxyl
245370,Add a benzene ring to the molecule CO[C@@H](CNC(=O)CC[C@@H]1CCCO1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)CC[C@@H]1CCCO1)c1ccc(F)cc1,benzene ring
61670,Add a amide to the molecule C/C(=C\C(=O)c1cccnc1)Nc1ccc(C)c(C)c1.,C/C(=C\C(=O)c1cccnc1)Nc1ccc(C)c(C)c1,amide
176954,Add a hydroxyl to the molecule Cn1cc([C@H]2CN(C(=O)Nc3ccnn3Cc3ccccn3)CCO2)cn1.,Cn1cc([C@H]2CN(C(=O)Nc3ccnn3Cc3ccccn3)CCO2)cn1,hydroxyl
33579,Please add a benzene ring to the molecule CCCc1ncc(C[NH+]2CCC3(CC2)CN(S(C)(=O)=O)Cc2ccccc2O3)cn1.,CCCc1ncc(C[NH+]2CCC3(CC2)CN(S(C)(=O)=O)Cc2ccccc2O3)cn1,benzene ring
191785,Add a benzene ring to the molecule Cc1c(C(=O)N2CC[C@@H](OCCC(C)C)C2)cnn1-c1ccncc1.,Cc1c(C(=O)N2CC[C@@H](OCCC(C)C)C2)cnn1-c1ccncc1,benzene ring
152365,Modify the molecule C[NH+](C)[C@@H]1CCC[C@@H](NC(=O)c2occc2Br)C1 by adding a amine.,C[NH+](C)[C@@H]1CCC[C@@H](NC(=O)c2occc2Br)C1,amine
155637,Add a amide to the molecule CCc1cccc(NC(=S)N(C)C)c1.,CCc1cccc(NC(=S)N(C)C)c1,amide
137420,Add a hydroxyl to the molecule Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1.,Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1,hydroxyl
19760,Add a benzene ring to the molecule C[C@H](NC(=O)N(C)[C@@H]1CCc2ccccc21)c1cccc(S(N)(=O)=O)c1.,C[C@H](NC(=O)N(C)[C@@H]1CCc2ccccc21)c1cccc(S(N)(=O)=O)c1,benzene ring
159918,Add a carboxyl to the molecule COc1cccc(CNC(=O)c2cc(S(=O)(=O)NC3CC3)ccc2Br)c1.,COc1cccc(CNC(=O)c2cc(S(=O)(=O)NC3CC3)ccc2Br)c1,carboxyl
187386,Modify the molecule COc1ccc(-c2ncc(C(=O)N3CC[C@@H](C(N)=O)C3)s2)cc1 by adding a halo.,COc1ccc(-c2ncc(C(=O)N3CC[C@@H](C(N)=O)C3)s2)cc1,halo
19594,Add a hydroxyl to the molecule Cc1csc(C2(NC(=O)CC3(O)CCCC3)CCCC2)n1.,Cc1csc(C2(NC(=O)CC3(O)CCCC3)CCCC2)n1,hydroxyl
156561,Modify the molecule CCC[NH+](C)C[C@@H]1CCN(C(=O)N[C@@H](CC)c2ccc3c(c2)OCCO3)C1 by adding a hydroxyl.,CCC[NH+](C)C[C@@H]1CCN(C(=O)N[C@@H](CC)c2ccc3c(c2)OCCO3)C1,hydroxyl
108316,Please add a benzene ring to the molecule CCC[NH+](C(C)C)[C@H](C)[C@H]([NH3+])c1ccc(C)cc1.,CCC[NH+](C(C)C)[C@H](C)[C@H]([NH3+])c1ccc(C)cc1,benzene ring
60651,Modify the molecule CC(C)C[C@@H](NS(C)(=O)=O)C(=O)N1CC[C@H](C(=O)[O-])[C@H]1C by adding a benzene ring.,CC(C)C[C@@H](NS(C)(=O)=O)C(=O)N1CC[C@H](C(=O)[O-])[C@H]1C,benzene ring
228965,Please add a aldehyde to the molecule Cc1cc(NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)n2ncnc2n1.,Cc1cc(NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)n2ncnc2n1,aldehyde
119325,Please add a hydroxyl to the molecule C[C@H]1CC(C(=O)N(CC[NH+](C)C)Cc2ccc(C#N)cc2)C[C@H](C)O1.,C[C@H]1CC(C(=O)N(CC[NH+](C)C)Cc2ccc(C#N)cc2)C[C@H](C)O1,hydroxyl
248862,Add a hydroxyl to the molecule CC1(C)O[C@H]2O[C@H]([C@H](O)c3cc(O)c4c(c3O)C(=O)c3ccccc3C4=O)[C@@](C)(O)[C@H]2O1.,CC1(C)O[C@H]2O[C@H]([C@H](O)c3cc(O)c4c(c3O)C(=O)c3ccccc3C4=O)[C@@](C)(O)[C@H]2O1,hydroxyl
101798,Modify the molecule N#Cc1ccccc1NC(=O)C(=O)NC[C@]1(O)CCOc2ccccc21 by adding a hydroxyl.,N#Cc1ccccc1NC(=O)C(=O)NC[C@]1(O)CCOc2ccccc21,hydroxyl
122752,Please add a nitrile to the molecule O=C(N[C@@H](c1ccc2c(c1)CCCC2)c1cccs1)c1ncccn1.,O=C(N[C@@H](c1ccc2c(c1)CCCC2)c1cccs1)c1ncccn1,nitrile
132206,Add a amine to the molecule Cc1cc(N)n(Cc2ccccn2)[nH+]1.,Cc1cc(N)n(Cc2ccccn2)[nH+]1,amine
199568,Modify the molecule Cc1ccc(NCC(=O)NNC(=O)c2ncccc2C(F)(F)F)c(C)c1 by adding a carboxyl.,Cc1ccc(NCC(=O)NNC(=O)c2ncccc2C(F)(F)F)c(C)c1,carboxyl
101374,Please add a hydroxyl to the molecule Cc1cc2oc(=O)cc(CN3C(=O)N[C@](C)(c4ccc5c(c4)CCC5)C3=O)c2cc1C.,Cc1cc2oc(=O)cc(CN3C(=O)N[C@](C)(c4ccc5c(c4)CCC5)C3=O)c2cc1C,hydroxyl
47442,Please add a hydroxyl to the molecule Cc1cc(C)cc(OCCNC(=O)CCN2C(=O)c3ccccc3C2=O)c1.,Cc1cc(C)cc(OCCNC(=O)CCN2C(=O)c3ccccc3C2=O)c1,hydroxyl
73371,Please add a benzene ring to the molecule CCC(C)(C)[C@@H]1CCC[NH+]1CCCc1nnc(C)o1.,CCC(C)(C)[C@@H]1CCC[NH+]1CCCc1nnc(C)o1,benzene ring
212632,Modify the molecule CC[C@@H]1CCC[C@@](C#N)([C@](C)(O)Cc2ccccc2)C1 by adding a hydroxyl.,CC[C@@H]1CCC[C@@](C#N)([C@](C)(O)Cc2ccccc2)C1,hydroxyl
228033,Modify the molecule CC[C@H](C)N1C(=O)[C@@H]2[C@H](CC(N)=O)N[C@@]3(C(=O)Nc4ccccc43)[C@@H]2C1=O by adding a nitro.,CC[C@H](C)N1C(=O)[C@@H]2[C@H](CC(N)=O)N[C@@]3(C(=O)Nc4ccccc43)[C@@H]2C1=O,nitro
216382,Please add a hydroxyl to the molecule CC(C)COc1ccc([C@@H]2CC(=O)N(c3ccccc3)c3c2sc(=O)n3C)cc1.,CC(C)COc1ccc([C@@H]2CC(=O)N(c3ccccc3)c3c2sc(=O)n3C)cc1,hydroxyl
89641,Add a amine to the molecule CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O.,CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O,amine
63874,Please add a amide to the molecule CN1c2cc(F)ccc2C(=O)NC12CCN(C(=O)NC1CCCCC1)CC2.,CN1c2cc(F)ccc2C(=O)NC12CCN(C(=O)NC1CCCCC1)CC2,amide
100611,Modify the molecule CN(CC1CC1)C(=O)CSc1nncc2c1[nH]c1ccc(F)cc12 by adding a amine.,CN(CC1CC1)C(=O)CSc1nncc2c1[nH]c1ccc(F)cc12,amine
153323,Modify the molecule OCCN1CCN(c2cc(-c3cncc(-c4cccs4)c3)nc(-c3ccccc3)n2)CC1 by adding a thiol.,OCCN1CCN(c2cc(-c3cncc(-c4cccs4)c3)nc(-c3ccccc3)n2)CC1,thiol
16409,Modify the molecule C/C=C(/C)C(=O)N1CC[NH+](C)Cc2ccccc21 by adding a aldehyde.,C/C=C(/C)C(=O)N1CC[NH+](C)Cc2ccccc21,aldehyde
76882,Please add a aldehyde to the molecule O=C(/C=C/c1cnc2ccccc2n1)NCc1ccc(S(=O)(=O)N2CCCC2)cc1.,O=C(/C=C/c1cnc2ccccc2n1)NCc1ccc(S(=O)(=O)N2CCCC2)cc1,aldehyde
48069,Add a halo to the molecule C[C@@H](c1ccccc1)[NH+]1CC[C@@H](N[C@H](C)CCCO)C1.,C[C@@H](c1ccccc1)[NH+]1CC[C@@H](N[C@H](C)CCCO)C1,halo
229393,Please add a aldehyde to the molecule c1ccc2c(c1)C[C@H](C[NH2+]CCC1CCCCC1)S2.,c1ccc2c(c1)C[C@H](C[NH2+]CCC1CCCCC1)S2,aldehyde
130797,Modify the molecule CCC(=O)N1CCc2cc(Br)ccc21 by adding a benzene ring.,CCC(=O)N1CCc2cc(Br)ccc21,benzene ring
1877,Modify the molecule CC(C)n1ccc(C(=O)NCC2(O)CCSCC2)n1 by adding a benzene ring.,CC(C)n1ccc(C(=O)NCC2(O)CCSCC2)n1,benzene ring
170767,Add a aldehyde to the molecule CCC[C@@]1(CO)CCCN(C(=O)c2coc(CN3CCOCC3)c2)C1.,CCC[C@@]1(CO)CCCN(C(=O)c2coc(CN3CCOCC3)c2)C1,aldehyde
34324,Modify the molecule c1cnc(N2CC[NH+]3CCCC[C@@H]3C2)c(C[NH2+]C2CC2)c1 by adding a amide.,c1cnc(N2CC[NH+]3CCCC[C@@H]3C2)c(C[NH2+]C2CC2)c1,amide
137544,Please add a carboxyl to the molecule Cc1ccnc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)n1.,Cc1ccnc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)n1,carboxyl
142902,Modify the molecule Cc1ccc(N2CCC[C@@H](NC(=O)COCC3CC3)C2)cc1 by adding a hydroxyl.,Cc1ccc(N2CCC[C@@H](NC(=O)COCC3CC3)C2)cc1,hydroxyl
38176,Modify the molecule O=C(NCc1ccc(F)cc1)c1nc2cc(Cl)ccn2c1F by adding a amide.,O=C(NCc1ccc(F)cc1)c1nc2cc(Cl)ccn2c1F,amide
21166,Modify the molecule CCOC(=O)c1ccc(CN2C[C@H]3[C@@H](C2)OCCN3Cc2ccccc2)o1 by adding a hydroxyl.,CCOC(=O)c1ccc(CN2C[C@H]3[C@@H](C2)OCCN3Cc2ccccc2)o1,hydroxyl
235435,Add a benzene ring to the molecule N/C(Cc1cccs1)=N\OC(=O)COc1ccc(Br)cc1.,N/C(Cc1cccs1)=N\OC(=O)COc1ccc(Br)cc1,benzene ring
121513,Add a benzene ring to the molecule CCOC(=O)[C@H]1NCCc2ccccc21.,CCOC(=O)[C@H]1NCCc2ccccc21,benzene ring
58204,Modify the molecule Cc1ccc(N2CCOC2=O)cc1NC(=O)c1oc2ccccc2c1C by adding a hydroxyl.,Cc1ccc(N2CCOC2=O)cc1NC(=O)c1oc2ccccc2c1C,hydroxyl
156677,Add a aldehyde to the molecule O=C(CSc1nnc(NC(=O)c2cccs2)s1)Nc1cccc2ccccc12.,O=C(CSc1nnc(NC(=O)c2cccs2)s1)Nc1cccc2ccccc12,aldehyde
68672,Add a hydroxyl to the molecule C[C@@H]1C[C@H]([NH3+])CN(CCCC(C)(C)C#N)C1.,C[C@@H]1C[C@H]([NH3+])CN(CCCC(C)(C)C#N)C1,hydroxyl
11623,Please add a amide to the molecule C[C@@H]1CN(C(=O)[C@@H](C)C(N)=S)C[C@@H]1C.,C[C@@H]1CN(C(=O)[C@@H](C)C(N)=S)C[C@@H]1C,amide
185687,Please add a benzene ring to the molecule [NH3+]C[C@H]1CCCC[C@H]1[NH+]1CCCCC1.,[NH3+]C[C@H]1CCCC[C@H]1[NH+]1CCCCC1,benzene ring
162427,Modify the molecule CC(C)[C@@H](NC(=O)c1ccccc1)C1([N+](=O)[O-])CCCCC1 by adding a hydroxyl.,CC(C)[C@@H](NC(=O)c1ccccc1)C1([N+](=O)[O-])CCCCC1,hydroxyl
90019,Modify the molecule Cc1nc(C)n(C[C@H](C)C(=O)N2CCN([C@H](c3ccccc3)c3[nH+]ccn3C)CC2)n1 by adding a carboxyl.,Cc1nc(C)n(C[C@H](C)C(=O)N2CCN([C@H](c3ccccc3)c3[nH+]ccn3C)CC2)n1,carboxyl
190500,Please add a amine to the molecule O=C(CCCc1nc(-c2ccc(Cl)cc2)no1)Nc1ccc([N+](=O)[O-])cc1.,O=C(CCCc1nc(-c2ccc(Cl)cc2)no1)Nc1ccc([N+](=O)[O-])cc1,amine
85178,Modify the molecule Oc1cccc(-c2c(-c3ccccc3)ncn2Cc2ccc3nonc3c2)c1 by adding a amide.,Oc1cccc(-c2c(-c3ccccc3)ncn2Cc2ccc3nonc3c2)c1,amide
149045,Please add a aldehyde to the molecule COc1ccc(-c2ccc3nnc(SCc4cccc(F)c4)n3n2)cc1.,COc1ccc(-c2ccc3nnc(SCc4cccc(F)c4)n3n2)cc1,aldehyde
29026,Add a benzene ring to the molecule Cc1ncsc1C(=O)N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccc(F)cc1.,Cc1ncsc1C(=O)N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccc(F)cc1,benzene ring
245647,Modify the molecule Cc1ccc(C)c(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)c1 by adding a hydroxyl.,Cc1ccc(C)c(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)c1,hydroxyl
113404,Please add a aldehyde to the molecule CC[C@H](C)C(=O)N1CCCC[C@H]1CC.,CC[C@H](C)C(=O)N1CCCC[C@H]1CC,aldehyde
18457,Add a amide to the molecule CCOC(=O)c1cc(Br)c(C)c(Br)c1.,CCOC(=O)c1cc(Br)c(C)c(Br)c1,amide
54940,Add a benzene ring to the molecule COc1ccc(F)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1F.,COc1ccc(F)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1F,benzene ring
135158,Modify the molecule O=C(NNS(=O)(=O)c1cc(Cl)ccc1Cl)c1ccc(Br)cc1 by adding a hydroxyl.,O=C(NNS(=O)(=O)c1cc(Cl)ccc1Cl)c1ccc(Br)cc1,hydroxyl
127842,Add a thiol to the molecule CN(C(=O)Cc1cccc(OCc2cccnc2)c1)C1CCCCC1.,CN(C(=O)Cc1cccc(OCc2cccnc2)c1)C1CCCCC1,thiol
71529,Add a nitro to the molecule CC[C@H](NC(=O)CCCc1cc(F)ccc1F)[C@H]1CCCO1.,CC[C@H](NC(=O)CCCc1cc(F)ccc1F)[C@H]1CCCO1,nitro
177643,Add a hydroxyl to the molecule COC[C@H](C)NC(=O)Cn1cccc2cc(C(F)F)nc1-2.,COC[C@H](C)NC(=O)Cn1cccc2cc(C(F)F)nc1-2,hydroxyl
123891,Add a carboxyl to the molecule COc1ccc(CN2C(=O)C[C@@H](C(=O)Nc3ccccc3OC)S/C2=N\c2ccc(F)cc2)cc1.,COc1ccc(CN2C(=O)C[C@@H](C(=O)Nc3ccccc3OC)S/C2=N\c2ccc(F)cc2)cc1,carboxyl
56122,Modify the molecule CO[C@H]1CCCC[C@H]1NC(=O)NCCC(=O)NCc1ccncc1 by adding a carboxyl.,CO[C@H]1CCCC[C@H]1NC(=O)NCCC(=O)NCc1ccncc1,carboxyl
238342,Modify the molecule CC(=O)c1c(C)[nH]c(C(=O)N2CCC(OCc3ccccc3C)CC2)c1C(C)C by adding a amine.,CC(=O)c1c(C)[nH]c(C(=O)N2CCC(OCc3ccccc3C)CC2)c1C(C)C,amine
203358,Please add a hydroxyl to the molecule Cc1ccc(C(=O)NCC(=O)N2CCC3(CC2)OC[C@@H](C)O3)cc1C.,Cc1ccc(C(=O)NCC(=O)N2CCC3(CC2)OC[C@@H](C)O3)cc1C,hydroxyl
92890,Add a nitrile to the molecule CNC(=O)NC(=O)CCSc1csc(C(=O)[O-])c1.,CNC(=O)NC(=O)CCSc1csc(C(=O)[O-])c1,nitrile
22296,Add a hydroxyl to the molecule CCn1ccc(C(=O)N2C[C@H]3CC[C@@H]2CN(C(=O)c2ccccc2)C3)cc1=O.,CCn1ccc(C(=O)N2C[C@H]3CC[C@@H]2CN(C(=O)c2ccccc2)C3)cc1=O,hydroxyl
142698,Add a nitro to the molecule C[C@@H](OC(=O)c1ccccc1)C(=O)Nc1cccc(S(N)(=O)=O)c1.,C[C@@H](OC(=O)c1ccccc1)C(=O)Nc1cccc(S(N)(=O)=O)c1,nitro
186599,Modify the molecule C[C@H]1CC[C@H](c2nc(=O)c(-c3ccc(Cl)cc3)c([O-])[nH]2)C1 by adding a benzene ring.,C[C@H]1CC[C@H](c2nc(=O)c(-c3ccc(Cl)cc3)c([O-])[nH]2)C1,benzene ring
27750,Add a hydroxyl to the molecule O=C(CCCCl)N(Cc1ccsc1)CC(F)(F)F.,O=C(CCCCl)N(Cc1ccsc1)CC(F)(F)F,hydroxyl
77360,Add a amine to the molecule CN(C(=O)c1ccc([N+](=O)[O-])cc1)[C@@H]1CCN(c2ccccc2)C1=O.,CN(C(=O)c1ccc([N+](=O)[O-])cc1)[C@@H]1CCN(c2ccccc2)C1=O,amine
64781,Add a carboxyl to the molecule CCCn1c(C)nnc1S[C@@H](C(=O)N1CCCC[C@H]1C)C(C)C.,CCCn1c(C)nnc1S[C@@H](C(=O)N1CCCC[C@H]1C)C(C)C,carboxyl
242796,Modify the molecule O=C(Nc1sccc1C(=O)[O-])c1cc2c(F)cccc2s1 by adding a benzene ring.,O=C(Nc1sccc1C(=O)[O-])c1cc2c(F)cccc2s1,benzene ring
116034,Add a benzene ring to the molecule COC[C@]1(Br)C=CC=CC1.,COC[C@]1(Br)C=CC=CC1,benzene ring
100804,Modify the molecule CCc1ccc(Oc2cc(NN)ncn2)cc1 by adding a amide.,CCc1ccc(Oc2cc(NN)ncn2)cc1,amide
213382,Add a benzene ring to the molecule O=C(CNC(=O)c1ccc2c(c1)CCC2)NC[C@@H]1CCC[C@@H](O)C1.,O=C(CNC(=O)c1ccc2c(c1)CCC2)NC[C@@H]1CCC[C@@H](O)C1,benzene ring
35747,Add a hydroxyl to the molecule COC(=O)[C@@H](C)Oc1ccc2c(-c3cc4ccc(OC)cc4oc3=O)cc(=O)oc2c1.,COC(=O)[C@@H](C)Oc1ccc2c(-c3cc4ccc(OC)cc4oc3=O)cc(=O)oc2c1,hydroxyl
33756,Please add a halo to the molecule CC(C)C[NH+](C)[C@H](C)C(=O)Nc1ccc(F)cc1N.,CC(C)C[NH+](C)[C@H](C)C(=O)Nc1ccc(F)cc1N,halo
239133,Modify the molecule CCOCCNC(=O)N1CCN(C(=O)c2ccc(CC)cc2)CC1 by adding a benzene ring.,CCOCCNC(=O)N1CCN(C(=O)c2ccc(CC)cc2)CC1,benzene ring
69053,Please add a hydroxyl to the molecule COc1ccccc1CC(=O)NCc1nccc2ccccc12.,COc1ccccc1CC(=O)NCc1nccc2ccccc12,hydroxyl
140323,Please add a hydroxyl to the molecule C[C@](N)(C(=O)NC[C@@H](O)CO)C(F)(F)F.,C[C@](N)(C(=O)NC[C@@H](O)CO)C(F)(F)F,hydroxyl
153586,Add a hydroxyl to the molecule Cc1c2c(cc3c1O/C(=C\c1c(F)cccc1Cl)C3=O)CN(C1CC1)CO2.,Cc1c2c(cc3c1O/C(=C\c1c(F)cccc1Cl)C3=O)CN(C1CC1)CO2,hydroxyl
72243,Add a halo to the molecule COc1cccc(CNC(=O)/C=C/c2ccc(Cl)c(Cl)c2)c1.,COc1cccc(CNC(=O)/C=C/c2ccc(Cl)c(Cl)c2)c1,halo
147018,Add a amide to the molecule C[C@@H]1CCC(=O)N(Cc2cccc(Cl)n2)CC1.,C[C@@H]1CCC(=O)N(Cc2cccc(Cl)n2)CC1,amide
16345,Please add a benzene ring to the molecule COc1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)NC(=O)CO4)CC2)cc1OC.,COc1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)NC(=O)CO4)CC2)cc1OC,benzene ring
25726,Add a carboxyl to the molecule Cc1ccc(N/C([S-])=[NH+]/Cc2ccccc2)cc1[N+](=O)[O-].,Cc1ccc(N/C([S-])=[NH+]/Cc2ccccc2)cc1[N+](=O)[O-],carboxyl
143025,Modify the molecule CC[C@H]1CN(C(=O)c2cc(COc3cccc(C(C)=O)c3)[nH]n2)CC[NH2+]1 by adding a aldehyde.,CC[C@H]1CN(C(=O)c2cc(COc3cccc(C(C)=O)c3)[nH]n2)CC[NH2+]1,aldehyde
183279,Please add a hydroxyl to the molecule COC[C@H]1CC[C@H](Cl)[C@@H]1C.,COC[C@H]1CC[C@H](Cl)[C@@H]1C,hydroxyl
97486,Add a aldehyde to the molecule CCC([NH3+])(CC)C(=O)Nc1cc([N+](=O)[O-])c(F)cc1F.,CCC([NH3+])(CC)C(=O)Nc1cc([N+](=O)[O-])c(F)cc1F,aldehyde
53993,Modify the molecule CCS[C@H]1CCCC[C@H]1NC(=O)Nc1cnccc1C by adding a hydroxyl.,CCS[C@H]1CCCC[C@H]1NC(=O)Nc1cnccc1C,hydroxyl
140178,Add a amide to the molecule CC(C)(C)c1ccc(/C(=N\O)N[C@H](O)C(Cl)(Cl)Cl)cc1.,CC(C)(C)c1ccc(/C(=N\O)N[C@H](O)C(Cl)(Cl)Cl)cc1,amide
231321,Add a amide to the molecule O=C(NCc1ccc(C(=O)Nc2cccnc2)cc1)c1cc2sccn2c1.,O=C(NCc1ccc(C(=O)Nc2cccnc2)cc1)c1cc2sccn2c1,amide
212430,Modify the molecule O=C([O-])/C=C/C(=O)Nc1ccc2[nH]ncc2c1 by adding a hydroxyl.,O=C([O-])/C=C/C(=O)Nc1ccc2[nH]ncc2c1,hydroxyl
62317,Please add a benzene ring to the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+]2CCc3n[nH]cc3C2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+]2CCc3n[nH]cc3C2)C1,benzene ring
213703,Modify the molecule C[NH+](C)[C@H]1CC[C@H](NC(=O)c2ccc(S[C@@H]3CCOC3=O)cc2)C1 by adding a hydroxyl.,C[NH+](C)[C@H]1CC[C@H](NC(=O)c2ccc(S[C@@H]3CCOC3=O)cc2)C1,hydroxyl
178153,Modify the molecule CSCCN(C)C(=O)c1ccc(-n2ccnn2)cc1 by adding a hydroxyl.,CSCCN(C)C(=O)c1ccc(-n2ccnn2)cc1,hydroxyl
217433,Add a amine to the molecule C[C@@H]1C[C@H](NC(=O)Cc2ccccc2O)CC[NH+]1C.,C[C@@H]1C[C@H](NC(=O)Cc2ccccc2O)CC[NH+]1C,amine
87596,Add a benzene ring to the molecule O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1.,O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1,benzene ring
201537,Modify the molecule COC(=O)c1ccc(Oc2ncnc(NC3CCCCCC3)c2[N+](=O)[O-])cc1 by adding a aldehyde.,COC(=O)c1ccc(Oc2ncnc(NC3CCCCCC3)c2[N+](=O)[O-])cc1,aldehyde
206569,Add a hydroxyl to the molecule Fc1ccccc1[C@@H]1CN(Cc2cnn3c2NCCC3)CCO1.,Fc1ccccc1[C@@H]1CN(Cc2cnn3c2NCCC3)CCO1,hydroxyl
68700,Please add a hydroxyl to the molecule O=C(N[C@@H]1CCCSC1)N1CCOC[C@@H]1C1CC1.,O=C(N[C@@H]1CCCSC1)N1CCOC[C@@H]1C1CC1,hydroxyl
98355,Add a carboxyl to the molecule CN(Cc1ccccc1N1CCOCC1)C(=O)c1scnc1C1CC1.,CN(Cc1ccccc1N1CCOCC1)C(=O)c1scnc1C1CC1,carboxyl
215847,Modify the molecule CNc1cc(C(=O)N(C)[C@H](C)c2ccc([S@@](C)=O)cc2)cc(Cl)n1 by adding a hydroxyl.,CNc1cc(C(=O)N(C)[C@H](C)c2ccc([S@@](C)=O)cc2)cc(Cl)n1,hydroxyl
22959,Please add a amine to the molecule CCCS(=O)(=O)N1CCC2(CC1)CC(=O)N(C/C=C/c1ccccc1)C2.,CCCS(=O)(=O)N1CCC2(CC1)CC(=O)N(C/C=C/c1ccccc1)C2,amine
97566,Modify the molecule Cc1nc(C(=O)N2CCC[C@@H](CCc3c(F)cccc3F)C2)cs1 by adding a hydroxyl.,Cc1nc(C(=O)N2CCC[C@@H](CCc3c(F)cccc3F)C2)cs1,hydroxyl
136855,Please add a halo to the molecule CCOc1cc2c(cc1NC(=O)c1cc(C(C)C)no1)O[C@@H](C)C2.,CCOc1cc2c(cc1NC(=O)c1cc(C(C)C)no1)O[C@@H](C)C2,halo
7068,Modify the molecule COC[C@H](C)[NH+]1CCN(CC(=O)NCc2ccc(C)c(F)c2)CC1 by adding a hydroxyl.,COC[C@H](C)[NH+]1CCN(CC(=O)NCc2ccc(C)c(F)c2)CC1,hydroxyl
29930,Add a amide to the molecule C[C@@]1(c2cccc(NC(=O)CN3C(=O)CCOc4ccccc43)c2)NC(=O)NC1=O.,C[C@@]1(c2cccc(NC(=O)CN3C(=O)CCOc4ccccc43)c2)NC(=O)NC1=O,amide
168858,Please add a aldehyde to the molecule CS[C@@H]1CC[C@@H](NC(=O)CNC(=O)c2cc(-c3ccccc3)on2)C1.,CS[C@@H]1CC[C@@H](NC(=O)CNC(=O)c2cc(-c3ccccc3)on2)C1,aldehyde
57778,Modify the molecule Cc1ccc(C[NH+](CCCC#N)Cc2ccco2)s1 by adding a nitro.,Cc1ccc(C[NH+](CCCC#N)Cc2ccco2)s1,nitro
140382,Add a halo to the molecule CCSc1nnc2c(n1)O[C@H](c1c(OC)cc(OC)cc1OC)Nc1ccccc1-2.,CCSc1nnc2c(n1)O[C@H](c1c(OC)cc(OC)cc1OC)Nc1ccccc1-2,halo
21917,Please add a hydroxyl to the molecule C[C@H]1C[C@@H](c2cccc(F)c2)N(CCc2cnn(C)c2)C1.,C[C@H]1C[C@@H](c2cccc(F)c2)N(CCc2cnn(C)c2)C1,hydroxyl
48670,Add a amide to the molecule O=C(c1cncc(-c2ccsc2)c1)N1CCC2(CC1)OCc1ccccc12.,O=C(c1cncc(-c2ccsc2)c1)N1CCC2(CC1)OCc1ccccc12,amide
49701,Please add a hydroxyl to the molecule O=C([O-])CCN1C(=O)/C(=C2/C(=O)N(Cc3ccccc3)c3ccccc32)SC1=S.,O=C([O-])CCN1C(=O)/C(=C2/C(=O)N(Cc3ccccc3)c3ccccc32)SC1=S,hydroxyl
215241,Add a amide to the molecule Cc1cccc(N2CCN(C(=O)CCS(=O)(=O)c3cc4c5c(c3)CCN5C(=O)CC4)CC2)c1C.,Cc1cccc(N2CCN(C(=O)CCS(=O)(=O)c3cc4c5c(c3)CCN5C(=O)CC4)CC2)c1C,amide
193061,Please add a hydroxyl to the molecule c1ccc(-n2ncc3c(NC4CCCCCC4)ncnc32)cc1.,c1ccc(-n2ncc3c(NC4CCCCCC4)ncnc32)cc1,hydroxyl
28016,Modify the molecule CCS(=O)(=O)CCN(C)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1 by adding a benzene ring.,CCS(=O)(=O)CCN(C)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1,benzene ring
64336,Modify the molecule C[C@@H](Sc1nnnn1C)C(=O)Nc1ccc(N(C)C)cc1 by adding a hydroxyl.,C[C@@H](Sc1nnnn1C)C(=O)Nc1ccc(N(C)C)cc1,hydroxyl
109460,Please add a benzene ring to the molecule CC[C@H](Cc1ccc(C)cc1)NC(=O)NCC(=O)NC1CC1.,CC[C@H](Cc1ccc(C)cc1)NC(=O)NCC(=O)NC1CC1,benzene ring
197461,Add a benzene ring to the molecule COc1cc(C)c(CSc2ccccc2N)cc1OC.,COc1cc(C)c(CSc2ccccc2N)cc1OC,benzene ring
45592,Please add a nitrile to the molecule COCC[NH+]1CCC[C@H]1CNS(=O)(=O)c1cc(C)c(C)s1.,COCC[NH+]1CCC[C@H]1CNS(=O)(=O)c1cc(C)c(C)s1,nitrile
242478,Modify the molecule C[C@]1(c2ccco2)NC(=O)N(CC(F)(F)F)C1=O by adding a hydroxyl.,C[C@]1(c2ccco2)NC(=O)N(CC(F)(F)F)C1=O,hydroxyl
182344,Please add a aldehyde to the molecule O=C(CCC(=O)N1CCOCC1)OCc1ncc(-c2ccc(F)cc2)o1.,O=C(CCC(=O)N1CCOCC1)OCc1ncc(-c2ccc(F)cc2)o1,aldehyde
180836,Modify the molecule CCCC[NH+]1CCCC[C@H]1CNC(=O)N(C)C[C@@H](C)O by adding a amine.,CCCC[NH+]1CCCC[C@H]1CNC(=O)N(C)C[C@@H](C)O,amine
16992,Add a hydroxyl to the molecule Cc1cc(=O)[nH]c(SCC(=O)Nc2ncc(Cc3ccc(F)cc3)s2)n1.,Cc1cc(=O)[nH]c(SCC(=O)Nc2ncc(Cc3ccc(F)cc3)s2)n1,hydroxyl
96705,Please add a benzene ring to the molecule CC[C@H](Br)C1CCCC1.,CC[C@H](Br)C1CCCC1,benzene ring
173768,Please add a amide to the molecule CC[C@@H](C(=O)Nc1ccccc1Cl)n1nc(-c2ccccc2)cc(NC(C)=O)c1=O.,CC[C@@H](C(=O)Nc1ccccc1Cl)n1nc(-c2ccccc2)cc(NC(C)=O)c1=O,amide
152797,Add a carboxyl to the molecule CNC(=O)c1cccc(NC(=O)C(=O)N2C[C@H]3CC=CC[C@H]3C2)c1C.,CNC(=O)c1cccc(NC(=O)C(=O)N2C[C@H]3CC=CC[C@H]3C2)c1C,carboxyl
2521,Please add a nitro to the molecule CN(Cc1nccn1Cc1ccccc1)C(=O)[C@@H]1C[C@H]1c1cccc(F)c1.,CN(Cc1nccn1Cc1ccccc1)C(=O)[C@@H]1C[C@H]1c1cccc(F)c1,nitro
102691,Please add a halo to the molecule O=C(NOCc1ccccc1)C1CCN(S(=O)(=O)c2ccccc2F)CC1.,O=C(NOCc1ccccc1)C1CCN(S(=O)(=O)c2ccccc2F)CC1,halo
49486,Please add a hydroxyl to the molecule O=C([O-])[C@H]1[C@H]2CC[C@H](C2)[C@H]1NC/C(Cl)=C/Cl.,O=C([O-])[C@H]1[C@H]2CC[C@H](C2)[C@H]1NC/C(Cl)=C/Cl,hydroxyl
94156,Please add a halo to the molecule C[C@H](NC(=O)[C@H]1CCC[NH+](C)C1)c1nnnn1-c1ccccc1.,C[C@H](NC(=O)[C@H]1CCC[NH+](C)C1)c1nnnn1-c1ccccc1,halo
175221,Modify the molecule CC(=O)Nc1ccc(Cl)c(C(=O)N[C@@H]2CCCc3ccc(F)cc32)c1 by adding a thiol.,CC(=O)Nc1ccc(Cl)c(C(=O)N[C@@H]2CCCc3ccc(F)cc32)c1,thiol
26642,Please add a amine to the molecule O=C(c1cn(Cc2ccccc2)nc1-c1cccnc1)N1CCN(c2ccccc2O)CC1.,O=C(c1cn(Cc2ccccc2)nc1-c1cccnc1)N1CCN(c2ccccc2O)CC1,amine
30790,Modify the molecule Cc1ccc(CC(=O)N2CCN(CC(C)(C)O)CC2)cn1 by adding a halo.,Cc1ccc(CC(=O)N2CCN(CC(C)(C)O)CC2)cn1,halo
52701,Please add a nitro to the molecule Cc1ccc([N+](=O)[O-])c(N2CC[C@H](C(N)=O)C2)c1.,Cc1ccc([N+](=O)[O-])c(N2CC[C@H](C(N)=O)C2)c1,nitro
188624,Add a hydroxyl to the molecule O=C(Nc1cc(-c2ccco2)ccc1F)c1ccc(Cn2cccn2)cc1.,O=C(Nc1cc(-c2ccco2)ccc1F)c1ccc(Cn2cccn2)cc1,hydroxyl
201898,Modify the molecule CC(C)CNC(=O)[C@@H](C)[S@](=O)Cc1ncoc1C(C)C by adding a benzene ring.,CC(C)CNC(=O)[C@@H](C)[S@](=O)Cc1ncoc1C(C)C,benzene ring
131337,Add a hydroxyl to the molecule COc1ccc(/C=C/CBr)cc1Br.,COc1ccc(/C=C/CBr)cc1Br,hydroxyl
47226,Modify the molecule F[C@H]1CCCC[C@@H]1Br by adding a carboxyl.,F[C@H]1CCCC[C@@H]1Br,carboxyl
143284,Please add a nitro to the molecule Cc1ccc(CNC(=O)C(=O)Nc2ccccc2OC[C@@H]2CCCCO2)c(C)c1.,Cc1ccc(CNC(=O)C(=O)Nc2ccccc2OC[C@@H]2CCCCO2)c(C)c1,nitro
20159,Modify the molecule O=C1C[C@@H](c2cccs2)[C@@H](c2ccccc2)C(=O)N1 by adding a nitro.,O=C1C[C@@H](c2cccs2)[C@@H](c2ccccc2)C(=O)N1,nitro
114859,Please add a hydroxyl to the molecule C=CCn1c(=O)c2c(nc3n2CCCN3c2ccccc2)n(C)c1=O.,C=CCn1c(=O)c2c(nc3n2CCCN3c2ccccc2)n(C)c1=O,hydroxyl
67694,Add a hydroxyl to the molecule O=C([O-])[C@H]1Cc2c([nH]c3ccccc23)[C@H](c2c[nH]c3ccccc23)[NH2+]1.,O=C([O-])[C@H]1Cc2c([nH]c3ccccc23)[C@H](c2c[nH]c3ccccc23)[NH2+]1,hydroxyl
18332,Modify the molecule Cc1cc(NC(=O)c2ccccc2-c2nc(-c3ccccc3)no2)no1 by adding a aldehyde.,Cc1cc(NC(=O)c2ccccc2-c2nc(-c3ccccc3)no2)no1,aldehyde
46125,Please add a amide to the molecule O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccccc1.,O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccccc1,amide
5802,Modify the molecule CC(C)N1C(=O)NC(=O)/C(=C/c2cc([N+](=O)[O-])ccc2N2CC[NH2+]CC2)C1=O by adding a amide.,CC(C)N1C(=O)NC(=O)/C(=C/c2cc([N+](=O)[O-])ccc2N2CC[NH2+]CC2)C1=O,amide
54240,Please add a carboxyl to the molecule Cn1ncnc1CCNC(=O)c1ccc(Oc2ccc(F)cc2F)cc1.,Cn1ncnc1CCNC(=O)c1ccc(Oc2ccc(F)cc2F)cc1,carboxyl
224749,Add a benzene ring to the molecule C[C@H]1CCC[C@@H]([NH+]2CCN(Cc3ccccn3)CC2)C1.,C[C@H]1CCC[C@@H]([NH+]2CCN(Cc3ccccn3)CC2)C1,benzene ring
86846,Modify the molecule C[C@H]1CCC[C@H](NC(=O)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)[C@@H]1C by adding a halo.,C[C@H]1CCC[C@H](NC(=O)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)[C@@H]1C,halo
166494,Please add a aldehyde to the molecule CCOc1ncccc1C(=O)Nc1cc(C(C)(C)C)nn1C.,CCOc1ncccc1C(=O)Nc1cc(C(C)(C)C)nn1C,aldehyde
98034,Please add a hydroxyl to the molecule CC(C)(C(=O)OCCNc1cccnn1)c1ccc(Br)cc1.,CC(C)(C(=O)OCCNc1cccnn1)c1ccc(Br)cc1,hydroxyl
136432,Please add a benzene ring to the molecule O=C(c1ccccc1O)N1CCN(Cc2ccc(Cl)o2)CC1.,O=C(c1ccccc1O)N1CCN(Cc2ccc(Cl)o2)CC1,benzene ring
22518,Please add a aldehyde to the molecule CNC(=O)c1scc(-c2ccc(F)cc2)c1-n1cccc1.,CNC(=O)c1scc(-c2ccc(F)cc2)c1-n1cccc1,aldehyde
75359,Modify the molecule COc1ccccc1NC(=O)CSc1nc2ccccc2n1CC(=O)N1C[C@@H](C)C[C@H](C)C1 by adding a benzene ring.,COc1ccccc1NC(=O)CSc1nc2ccccc2n1CC(=O)N1C[C@@H](C)C[C@H](C)C1,benzene ring
112187,Modify the molecule CC(C)c1cc(C(=O)N(Cc2ccccc2C(F)(F)F)C2CC2)nn1C by adding a hydroxyl.,CC(C)c1cc(C(=O)N(Cc2ccccc2C(F)(F)F)C2CC2)nn1C,hydroxyl
84898,Modify the molecule C[C@@H](NC(=O)Cc1ccc2c(c1)CCCC2)C(=O)N1CCOCC1 by adding a halo.,C[C@@H](NC(=O)Cc1ccc2c(c1)CCCC2)C(=O)N1CCOCC1,halo
155472,Add a carboxyl to the molecule C[C@H](c1ccc(F)c(F)c1)N(C)C(=O)N[C@H]1CCc2c(O)cccc21.,C[C@H](c1ccc(F)c(F)c1)N(C)C(=O)N[C@H]1CCc2c(O)cccc21,carboxyl
177033,Add a benzene ring to the molecule CCC[NH2+][C@@H](C1CC1)[C@@H]1CCOC2(CCOCC2)C1.,CCC[NH2+][C@@H](C1CC1)[C@@H]1CCOC2(CCOCC2)C1,benzene ring
18370,Please add a hydroxyl to the molecule O[C@@H](c1ccccc1)C1(C[NH2+]C2CCN(c3cccc[nH+]3)CC2)CC1.,O[C@@H](c1ccccc1)C1(C[NH2+]C2CCN(c3cccc[nH+]3)CC2)CC1,hydroxyl
129138,Please add a benzene ring to the molecule COc1ccc(C[C@H](C)CNC(=O)Nc2c[nH]nc2-c2ccccn2)cc1.,COc1ccc(C[C@H](C)CNC(=O)Nc2c[nH]nc2-c2ccccn2)cc1,benzene ring
193410,Please add a aldehyde to the molecule O=C(NCCc1cn2ccccc2n1)NCc1ccnc(OC2CCC2)c1.,O=C(NCCc1cn2ccccc2n1)NCc1ccnc(OC2CCC2)c1,aldehyde
103590,Add a hydroxyl to the molecule O=S(=O)(CCCF)/N=C([O-])/C=C/c1ccc(N2CCOCC2)cc1.,O=S(=O)(CCCF)/N=C([O-])/C=C/c1ccc(N2CCOCC2)cc1,hydroxyl
191159,Add a halo to the molecule O=C(CN1CCOCC1)N1CCC[C@@H](c2nnc(-c3nccc4ccccc34)o2)C1.,O=C(CN1CCOCC1)N1CCC[C@@H](c2nnc(-c3nccc4ccccc34)o2)C1,halo
3730,Add a amine to the molecule COc1cccc(CSCc2csc(-c3ccco3)n2)c1.,COc1cccc(CSCc2csc(-c3ccco3)n2)c1,amine
215468,Modify the molecule O=S(=O)(NC[C@](O)(c1ccco1)C1CC1)c1cccc(C(F)(F)F)c1 by adding a benzene ring.,O=S(=O)(NC[C@](O)(c1ccco1)C1CC1)c1cccc(C(F)(F)F)c1,benzene ring
215312,Please add a hydroxyl to the molecule C[NH+](CCCCN1C(=O)c2ccccc2C1=O)[C@@H]1CCc2ccccc21.,C[NH+](CCCCN1C(=O)c2ccccc2C1=O)[C@@H]1CCc2ccccc21,hydroxyl
137308,Please add a benzene ring to the molecule O=C(C1=c2ccccc2=[NH+]C1)[C@@H](S[C@@H]1NN=NN1C1CCCC1)c1ccccc1.,O=C(C1=c2ccccc2=[NH+]C1)[C@@H](S[C@@H]1NN=NN1C1CCCC1)c1ccccc1,benzene ring
143631,Modify the molecule C[C@@H](c1ccccc1)[NH+]1CC[C@H](N2CCc3cc(S(N)(=O)=O)ccc32)C1 by adding a aldehyde.,C[C@@H](c1ccccc1)[NH+]1CC[C@H](N2CCc3cc(S(N)(=O)=O)ccc32)C1,aldehyde
28523,Add a amine to the molecule COc1cc([C@@H]2N[C@H](C(=O)[O-])CS2)ccc1OC(=O)c1ccccc1.,COc1cc([C@@H]2N[C@H](C(=O)[O-])CS2)ccc1OC(=O)c1ccccc1,amine
35732,Add a hydroxyl to the molecule CC1(C)C[C@H]([NH2+]C[C@@H]2CCC[C@@H]2NS(C)(=O)=O)C(C)(C)O1.,CC1(C)C[C@H]([NH2+]C[C@@H]2CCC[C@@H]2NS(C)(=O)=O)C(C)(C)O1,hydroxyl
136882,Modify the molecule COc1ccc2c(c1)[C@@]1(SCCN1C(=O)C1CCCC1)C(=O)N2Cc1ccccc1Cl by adding a carboxyl.,COc1ccc2c(c1)[C@@]1(SCCN1C(=O)C1CCCC1)C(=O)N2Cc1ccccc1Cl,carboxyl
231531,Add a amine to the molecule C[C@@H](CC(=O)c1ccccc1F)C(=O)N[C@@H]1CC(=O)N(c2ccccc2)C1.,C[C@@H](CC(=O)c1ccccc1F)C(=O)N[C@@H]1CC(=O)N(c2ccccc2)C1,amine
63622,Please add a nitro to the molecule CC(=O)[C@H]1[C@H](c2cccc(OCc3ccccc3)c2)NC(=O)N[C@]1(O)C(F)(F)F.,CC(=O)[C@H]1[C@H](c2cccc(OCc3ccccc3)c2)NC(=O)N[C@]1(O)C(F)(F)F,nitro
156602,Add a amide to the molecule COc1ccc(OC)c(C(=O)/C=C/c2ccccc2OC(=O)N2CCOCC2)c1.,COc1ccc(OC)c(C(=O)/C=C/c2ccccc2OC(=O)N2CCOCC2)c1,amide
99480,Please add a nitro to the molecule CCCNc1ncc(CN2C[C@@H]3CCC[NH+]3C[C@@H]2C)s1.,CCCNc1ncc(CN2C[C@@H]3CCC[NH+]3C[C@@H]2C)s1,nitro
89834,Add a carboxyl to the molecule Cc1nn(CN2C[C@H](C)O[C@@H](C)C2)c(=S)n1Cc1ccccc1.,Cc1nn(CN2C[C@H](C)O[C@@H](C)C2)c(=S)n1Cc1ccccc1,carboxyl
203856,Please add a amide to the molecule N#CCOc1ccc(C(=O)/C=C/c2cnc(-c3ccccc3)s2)cc1.,N#CCOc1ccc(C(=O)/C=C/c2cnc(-c3ccccc3)s2)cc1,amide
62035,Please add a halo to the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)[NH+](C)Cc1ccc(F)c(F)c1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)[NH+](C)Cc1ccc(F)c(F)c1,halo
169030,Add a benzene ring to the molecule CCOC(=O)C1(C)CC[NH+]([C@@H](C)c2ccccn2)CC1.,CCOC(=O)C1(C)CC[NH+]([C@@H](C)c2ccccn2)CC1,benzene ring
204921,Please add a halo to the molecule O=C(C[C@@H](c1ccc(Cl)cc1)C1C(=O)NC(=S)NC1=O)c1ccc(Cl)cc1.,O=C(C[C@@H](c1ccc(Cl)cc1)C1C(=O)NC(=S)NC1=O)c1ccc(Cl)cc1,halo
135856,Please add a carboxyl to the molecule O=C(C[C@H]1OC(=O)c2ccccc21)NC[C@@H]1CCCN(c2ncccn2)C1.,O=C(C[C@H]1OC(=O)c2ccccc21)NC[C@@H]1CCCN(c2ncccn2)C1,carboxyl
76696,Add a benzene ring to the molecule O=C(c1cccc(Cn2cccn2)c1)N1CCO[C@H](C(F)(F)F)C1.,O=C(c1cccc(Cn2cccn2)c1)N1CCO[C@H](C(F)(F)F)C1,benzene ring
191019,Add a hydroxyl to the molecule Cc1n[nH]c(C(=O)N2CCN(S(C)(=O)=O)CC2)n1.,Cc1n[nH]c(C(=O)N2CCN(S(C)(=O)=O)CC2)n1,hydroxyl
148581,Add a benzene ring to the molecule O=C(OCc1nc(C2CC2)cs1)C1(c2ccccc2)CCOCC1.,O=C(OCc1nc(C2CC2)cs1)C1(c2ccccc2)CCOCC1,benzene ring
80785,Add a aldehyde to the molecule Cc1ccc(N(C)[C@@H](C)Cc2cccs2)c(N)c1.,Cc1ccc(N(C)[C@@H](C)Cc2cccs2)c(N)c1,aldehyde
245602,Please add a hydroxyl to the molecule CSCC[C@H](NC(=O)c1ccccc1Cl)C(=O)Nc1ccc(F)c(F)c1.,CSCC[C@H](NC(=O)c1ccccc1Cl)C(=O)Nc1ccc(F)c(F)c1,hydroxyl
76287,Add a aldehyde to the molecule COc1ccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2C(=O)Cc2cccs2)cc1.,COc1ccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2C(=O)Cc2cccs2)cc1,aldehyde
235029,Add a hydroxyl to the molecule Cc1cccc2nnc(N3CCC[C@@H](C(=O)NCc4cccs4)C3)n12.,Cc1cccc2nnc(N3CCC[C@@H](C(=O)NCc4cccs4)C3)n12,hydroxyl
199577,Modify the molecule Cc1ccc(Cc2nc(C(=O)Nc3ccc([N+](=O)[O-])c(C)n3)cs2)cc1 by adding a benzene ring.,Cc1ccc(Cc2nc(C(=O)Nc3ccc([N+](=O)[O-])c(C)n3)cs2)cc1,benzene ring
114026,Modify the molecule CC[C@@H](O)CC[NH2+][C@H](c1ccccc1)C(C)C by adding a amide.,CC[C@@H](O)CC[NH2+][C@H](c1ccccc1)C(C)C,amide
17707,Modify the molecule CCOC(=O)Nc1ccc(S(=O)(=O)N2CCCC[C@H]2C)cc1 by adding a amide.,CCOC(=O)Nc1ccc(S(=O)(=O)N2CCCC[C@H]2C)cc1,amide
117933,Please add a hydroxyl to the molecule Cc1cc2n(n1)CCN(Cc1ncccc1C(=O)[O-])C2.,Cc1cc2n(n1)CCN(Cc1ncccc1C(=O)[O-])C2,hydroxyl
193986,Add a amide to the molecule Cn1cc(C(=O)Nc2cccc(N3CCOC3=O)c2)c(C(C)(C)C)n1.,Cn1cc(C(=O)Nc2cccc(N3CCOC3=O)c2)c(C(C)(C)C)n1,amide
159840,Modify the molecule CC[C@H](NS(=O)(=O)CCC1CC1)c1ccccc1O by adding a benzene ring.,CC[C@H](NS(=O)(=O)CCC1CC1)c1ccccc1O,benzene ring
20238,Please add a hydroxyl to the molecule COc1ccccc1CC(=O)Nc1cc(C)ccc1NC(=O)C1CCCCC1.,COc1ccccc1CC(=O)Nc1cc(C)ccc1NC(=O)C1CCCCC1,hydroxyl
26347,Please add a carboxyl to the molecule Cc1ccc(C)c(C(=O)NNC(=O)[C@@H]2CCS(=O)(=O)C2)c1.,Cc1ccc(C)c(C(=O)NNC(=O)[C@@H]2CCS(=O)(=O)C2)c1,carboxyl
5459,Please add a halo to the molecule CNS(=O)(=O)c1cccc([C@H](C)NC(=O)Nc2ccc(C)c(F)c2)c1.,CNS(=O)(=O)c1cccc([C@H](C)NC(=O)Nc2ccc(C)c(F)c2)c1,halo
175376,Modify the molecule Cn1ccnc1[C@H](NC(=O)COc1ccc2ccccc2c1)c1ccc(F)cc1 by adding a thiol.,Cn1ccnc1[C@H](NC(=O)COc1ccc2ccccc2c1)c1ccc(F)cc1,thiol
24801,Modify the molecule O=C([O-])COCC(=O)/N=C1\S[C@@H]2CS(=O)(=O)C[C@H]2N1c1ccc(Cl)cc1 by adding a benzene ring.,O=C([O-])COCC(=O)/N=C1\S[C@@H]2CS(=O)(=O)C[C@H]2N1c1ccc(Cl)cc1,benzene ring
58618,Please add a benzene ring to the molecule O=C1CCC(=O)N1C[C@H](O)Cn1c2ccccc2c2ccccc21.,O=C1CCC(=O)N1C[C@H](O)Cn1c2ccccc2c2ccccc21,benzene ring
195151,Add a amine to the molecule CCc1cc(N2CCOCC2)nc(-c2ccc([N+](=O)[O-])cc2)n1.,CCc1cc(N2CCOCC2)nc(-c2ccc([N+](=O)[O-])cc2)n1,amine
29161,Modify the molecule CCOC(=O)c1cc(C(=O)Nc2nc(C)cs2)cc([N+](=O)[O-])c1 by adding a amide.,CCOC(=O)c1cc(C(=O)Nc2nc(C)cs2)cc([N+](=O)[O-])c1,amide
214037,Modify the molecule C[C@@H](c1nc2sc3c(c2c(=O)[nH]1)CC[C@@H](C)C3)[NH+]1CCC(C(=O)Nc2ccccc2O)CC1 by adding a hydroxyl.,C[C@@H](c1nc2sc3c(c2c(=O)[nH]1)CC[C@@H](C)C3)[NH+]1CCC(C(=O)Nc2ccccc2O)CC1,hydroxyl
22470,Modify the molecule Cc1ccc(N2C[C@@H](C(=O)NCC3CCN(C(=O)c4ccccn4)CC3)CC2=O)cc1 by adding a aldehyde.,Cc1ccc(N2C[C@@H](C(=O)NCC3CCN(C(=O)c4ccccn4)CC3)CC2=O)cc1,aldehyde
69355,Add a hydroxyl to the molecule CCN(CC)C(=O)c1ccc(NC(=O)[C@H]2CCC(=O)O2)cc1Cl.,CCN(CC)C(=O)c1ccc(NC(=O)[C@H]2CCC(=O)O2)cc1Cl,hydroxyl
27333,Add a halo to the molecule CC[C@@H]1CCC[C@H](NC(=O)C(=O)Nc2cc(COC)ncn2)C1.,CC[C@@H]1CCC[C@H](NC(=O)C(=O)Nc2cc(COC)ncn2)C1,halo
86737,Modify the molecule O=C(NCCc1nnc(-c2ccccc2)o1)N[C@H]1CCCC[C@@H]1O by adding a benzene ring.,O=C(NCCc1nnc(-c2ccccc2)o1)N[C@H]1CCCC[C@@H]1O,benzene ring
230736,Add a benzene ring to the molecule O=c1[nH]c(Cc2ccc(Br)cc2)nc2ccccc12.,O=c1[nH]c(Cc2ccc(Br)cc2)nc2ccccc12,benzene ring
37304,Please add a hydroxyl to the molecule Cc1cc(C[NH+](C)C(C)(C)CO)c(OC(F)F)cc1C.,Cc1cc(C[NH+](C)C(C)(C)CO)c(OC(F)F)cc1C,hydroxyl
84802,Please add a amide to the molecule CCOC(=O)[C@@H]1CC[C@H](NC(=O)c2cccc(-c3ccoc3)c2)C1.,CCOC(=O)[C@@H]1CC[C@H](NC(=O)c2cccc(-c3ccoc3)c2)C1,amide
44697,Please add a nitro to the molecule CCOC(=O)N1CC[N+](=C(N)Nc2nc(C)cc(C)n2)CC1.,CCOC(=O)N1CC[N+](=C(N)Nc2nc(C)cc(C)n2)CC1,nitro
156730,Modify the molecule CC[C@@H](C)CN(CC)C(=O)N[C@@H](c1ccc(Cl)cc1)c1ncon1 by adding a nitrile.,CC[C@@H](C)CN(CC)C(=O)N[C@@H](c1ccc(Cl)cc1)c1ncon1,nitrile
166881,Add a amide to the molecule Cc1ccc2[nH]c(=O)c([C@H](c3nnnn3C3CCCC3)[NH+]3CCN(c4ccccc4F)CC3)cc2c1.,Cc1ccc2[nH]c(=O)c([C@H](c3nnnn3C3CCCC3)[NH+]3CCN(c4ccccc4F)CC3)cc2c1,amide
167144,Modify the molecule COC(=O)CCNC(=O)Cc1ccc2ccccc2c1 by adding a hydroxyl.,COC(=O)CCNC(=O)Cc1ccc2ccccc2c1,hydroxyl
32925,Please add a nitro to the molecule CC(C)c1nn(C)cc1C[NH2+]CCCn1cnc2ccccc21.,CC(C)c1nn(C)cc1C[NH2+]CCCn1cnc2ccccc21,nitro
178775,Please add a aldehyde to the molecule COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1.,COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1,aldehyde
127331,Add a hydroxyl to the molecule Cc1cc(NC(=O)c2cccn(CC(=O)Nc3nc4c(s3)C[C@H](C)CC4)c2=O)no1.,Cc1cc(NC(=O)c2cccn(CC(=O)Nc3nc4c(s3)C[C@H](C)CC4)c2=O)no1,hydroxyl
3555,Please add a amine to the molecule Cc1ccc(NC(=O)C2(c3ccc(F)cc3)CC2)cc1S(C)(=O)=O.,Cc1ccc(NC(=O)C2(c3ccc(F)cc3)CC2)cc1S(C)(=O)=O,amine
57117,Modify the molecule c1ccc(-c2ccc(Cc3nn4c(-c5cccnc5)nnc4s3)cc2)cc1 by adding a amine.,c1ccc(-c2ccc(Cc3nn4c(-c5cccnc5)nnc4s3)cc2)cc1,amine
42475,Please add a amide to the molecule CC(C)c1nc([C@H](C)[NH2+][C@@H]2CC(=O)N(Cc3ccccc3)[C@H]2C)cs1.,CC(C)c1nc([C@H](C)[NH2+][C@@H]2CC(=O)N(Cc3ccccc3)[C@H]2C)cs1,amide
36951,Please add a hydroxyl to the molecule CC[C@H]1CCC[C@@H]([C@@H](Cc2ccccc2F)C(=O)[O-])C1.,CC[C@H]1CCC[C@@H]([C@@H](Cc2ccccc2F)C(=O)[O-])C1,hydroxyl
3650,Please add a benzene ring to the molecule CNC(=O)c1ccc(CN(C)C(=O)c2cc(OC)ccc2O)cc1.,CNC(=O)c1ccc(CN(C)C(=O)c2cc(OC)ccc2O)cc1,benzene ring
207015,Add a hydroxyl to the molecule COc1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccc3oc(C)nc3c2)C1.,COc1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccc3oc(C)nc3c2)C1,hydroxyl
231341,Please add a amide to the molecule C=CCNC(=O)[C@@]1(C#N)O[C@H]1c1ccccc1.,C=CCNC(=O)[C@@]1(C#N)O[C@H]1c1ccccc1,amide
57718,Please add a hydroxyl to the molecule O=C(N[C@H]1CCS(=O)(=O)C1)c1ccc(-n2cncn2)cc1.,O=C(N[C@H]1CCS(=O)(=O)C1)c1ccc(-n2cncn2)cc1,hydroxyl
10399,Please add a hydroxyl to the molecule CCc1nc2c(s1)[C@H](NCc1cccc(OCC(F)F)c1)CCC2.,CCc1nc2c(s1)[C@H](NCc1cccc(OCC(F)F)c1)CCC2,hydroxyl
42042,Please add a carboxyl to the molecule C[C@H]1[C@@H](C)N(C(=O)N[C@@H]2CCc3cc(Cl)ccc32)CCS1(=O)=O.,C[C@H]1[C@@H](C)N(C(=O)N[C@@H]2CCc3cc(Cl)ccc32)CCS1(=O)=O,carboxyl
35630,Modify the molecule COC(=O)c1ccc(C)c(NC(=O)c2cc(Cl)ccc2F)c1 by adding a benzene ring.,COC(=O)c1ccc(C)c(NC(=O)c2cc(Cl)ccc2F)c1,benzene ring
116837,Add a hydroxyl to the molecule Cc1nc(CNC(=O)c2ccc(C(C)(C)C)cc2)n[nH]1.,Cc1nc(CNC(=O)c2ccc(C(C)(C)C)cc2)n[nH]1,hydroxyl
102979,Add a carboxyl to the molecule Cc1ccc(C)c(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3[C@H]2CCS(=O)(=O)C2)c1.,Cc1ccc(C)c(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3[C@H]2CCS(=O)(=O)C2)c1,carboxyl
78823,Add a amide to the molecule C[C@H](NC(=O)CNC(=O)c1cccs1)c1ccc(-c2cncnc2)cc1.,C[C@H](NC(=O)CNC(=O)c1cccs1)c1ccc(-c2cncnc2)cc1,amide
163564,Please add a amine to the molecule C=CCn1c(=O)c2ccccc2n2c(SCC(=O)N(C)Cc3c(F)cccc3Cl)nnc12.,C=CCn1c(=O)c2ccccc2n2c(SCC(=O)N(C)Cc3c(F)cccc3Cl)nnc12,amine
39469,Please add a hydroxyl to the molecule COc1ccc(N2C(=O)c3ccc(C(=O)N4CCN(C=O)CC4)cc3C2=O)cc1.,COc1ccc(N2C(=O)c3ccc(C(=O)N4CCN(C=O)CC4)cc3C2=O)cc1,hydroxyl
163524,Add a thiol to the molecule Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1.,Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1,thiol
163875,Modify the molecule CC(C)[NH2+][C@@]1(CO)CCC[C@H]1CCO[C@@H]1CCOC1 by adding a benzene ring.,CC(C)[NH2+][C@@]1(CO)CCC[C@H]1CCO[C@@H]1CCOC1,benzene ring
193150,Add a hydroxyl to the molecule COc1ccc(NC(=O)CCN2C(=O)/C(=C/c3ccccc3O)SC2=S)cc1.,COc1ccc(NC(=O)CCN2C(=O)/C(=C/c3ccccc3O)SC2=S)cc1,hydroxyl
142942,Add a halo to the molecule C[C@@H](O)C[C@@H]1CCC[NH+]1Cc1ccc([S@](C)=O)cc1.,C[C@@H](O)C[C@@H]1CCC[NH+]1Cc1ccc([S@](C)=O)cc1,halo
143488,Add a halo to the molecule Cc1ccccc1-c1ccc(C[NH+]2CCN(C3CC[NH+](C)CC3)[C@@H](CCO)C2)cc1.,Cc1ccccc1-c1ccc(C[NH+]2CCN(C3CC[NH+](C)CC3)[C@@H](CCO)C2)cc1,halo
94029,Add a amide to the molecule C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)OCc1cnn(C)c1.,C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)OCc1cnn(C)c1,amide
224062,Modify the molecule O=C(NC[C@@H](O)c1ccc(F)cc1)N[C@H]1CC(=O)N(C2CC2)C1 by adding a aldehyde.,O=C(NC[C@@H](O)c1ccc(F)cc1)N[C@H]1CC(=O)N(C2CC2)C1,aldehyde
225638,Add a halo to the molecule COc1ccc(NC(=O)C(=O)NCCSc2ccc(Cl)cc2)cc1Cl.,COc1ccc(NC(=O)C(=O)NCCSc2ccc(Cl)cc2)cc1Cl,halo
214963,Add a hydroxyl to the molecule Cn1cnc(S(=O)(=O)N[C@@H]2CCc3cc(Cl)ccc32)c1.,Cn1cnc(S(=O)(=O)N[C@@H]2CCc3cc(Cl)ccc32)c1,hydroxyl
96189,Modify the molecule O=C(COc1ccccc1)N[C@H](Cc1ccccc1)C(=O)N1CCCC1 by adding a hydroxyl.,O=C(COc1ccccc1)N[C@H](Cc1ccccc1)C(=O)N1CCCC1,hydroxyl
75921,Modify the molecule CCCC[NH+](C)[C@H](C)C(=O)NC(=O)Nc1ccc(C)cc1C by adding a hydroxyl.,CCCC[NH+](C)[C@H](C)C(=O)NC(=O)Nc1ccc(C)cc1C,hydroxyl
8441,Add a hydroxyl to the molecule CCc1nn(C)cc1C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl.,CCc1nn(C)cc1C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl,hydroxyl
217002,Please add a aldehyde to the molecule COCCN(C(=O)N1CC[C@H](C(=O)[O-])[C@H]1C)[C@@H](C)COC.,COCCN(C(=O)N1CC[C@H](C(=O)[O-])[C@H]1C)[C@@H](C)COC,aldehyde
49000,Add a hydroxyl to the molecule CCc1ncc(C[NH+]2CCC[C@H]2CN2Cc3ccccc3OC[C@@H]2C[NH+](C)C)cn1.,CCc1ncc(C[NH+]2CCC[C@H]2CN2Cc3ccccc3OC[C@@H]2C[NH+](C)C)cn1,hydroxyl
21686,Modify the molecule O=C(C[NH+]1CCN(Cc2nc(-c3ccc(Cl)cc3)no2)CC1)Nc1cccc(F)c1 by adding a benzene ring.,O=C(C[NH+]1CCN(Cc2nc(-c3ccc(Cl)cc3)no2)CC1)Nc1cccc(F)c1,benzene ring
51661,Add a halo to the molecule O=C(Nc1cnc(-c2ccccc2)s1)c1ccc(-n2ccnc2)cc1.,O=C(Nc1cnc(-c2ccccc2)s1)c1ccc(-n2ccnc2)cc1,halo
235965,Modify the molecule Cc1nc2ccc(NC(=O)C(=O)N3CCO[C@H](c4ccccc4F)C3)cc2o1 by adding a hydroxyl.,Cc1nc2ccc(NC(=O)C(=O)N3CCO[C@H](c4ccccc4F)C3)cc2o1,hydroxyl
7098,Please add a carboxyl to the molecule CN(CC[C@H]1CCCCO1)C(=O)[C@H]1C=C(Cn2ccc3ccccc32)N=N1.,CN(CC[C@H]1CCCCO1)C(=O)[C@H]1C=C(Cn2ccc3ccccc32)N=N1,carboxyl
9343,Modify the molecule CCS(=O)(=O)CCn1ccc(N[C@@H](C)c2cccc(Cl)c2)n1 by adding a hydroxyl.,CCS(=O)(=O)CCn1ccc(N[C@@H](C)c2cccc(Cl)c2)n1,hydroxyl
23430,Add a benzene ring to the molecule C[C@H]1CCC[C@H](NC(=O)NCCC[NH+](C)CC(F)(F)F)C1.,C[C@H]1CCC[C@H](NC(=O)NCCC[NH+](C)CC(F)(F)F)C1,benzene ring
165520,Modify the molecule CC(C)Oc1ccc(NC(=O)c2cccs2)cc1 by adding a benzene ring.,CC(C)Oc1ccc(NC(=O)c2cccs2)cc1,benzene ring
47991,Please add a nitro to the molecule CN1C(=O)[C@@]2(c3ccccc31)[C@H]1C[C@@H](C(C)(C)C)CC=C1C(C#N)=C(N)C2(C#N)C#N.,CN1C(=O)[C@@]2(c3ccccc31)[C@H]1C[C@@H](C(C)(C)C)CC=C1C(C#N)=C(N)C2(C#N)C#N,nitro
224268,Please add a carboxyl to the molecule C[NH2+][C@@H](C1CCCCC1)[C@H]1CCOC2(CCSCC2)C1.,C[NH2+][C@@H](C1CCCCC1)[C@H]1CCOC2(CCSCC2)C1,carboxyl
224783,Modify the molecule C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)CC1 by adding a benzene ring.,C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3[nH]c(=O)[nH]c3c2)CC1,benzene ring
94579,Add a amide to the molecule COc1ccc(C[C@H]2S/C(=N/N=C/c3ccc(OC(C)C)cc3)NC2=O)cc1.,COc1ccc(C[C@H]2S/C(=N/N=C/c3ccc(OC(C)C)cc3)NC2=O)cc1,amide
9126,Please add a benzene ring to the molecule C[NH2+]C[C@H]1C[C@H]1c1cccs1.,C[NH2+]C[C@H]1C[C@H]1c1cccs1,benzene ring
17749,Add a benzene ring to the molecule CC[NH+](CC)[C@@H](C)CNC(=O)c1cccc(OC)n1.,CC[NH+](CC)[C@@H](C)CNC(=O)c1cccc(OC)n1,benzene ring
66824,Add a amide to the molecule O=C(C[S@](=O)Cc1ccccc1)N1CCc2sccc2C1.,O=C(C[S@](=O)Cc1ccccc1)N1CCc2sccc2C1,amide
81113,Please add a benzene ring to the molecule O=C(Cc1n[nH]c(=O)c2ccccc12)NCc1cn(-c2ccccc2)nc1-c1ccc(F)cc1.,O=C(Cc1n[nH]c(=O)c2ccccc12)NCc1cn(-c2ccccc2)nc1-c1ccc(F)cc1,benzene ring
3119,Modify the molecule CC(=O)N[C@H]1C(=O)N=C(SCC(=O)Nc2cccc3ccccc23)NC1=O by adding a nitro.,CC(=O)N[C@H]1C(=O)N=C(SCC(=O)Nc2cccc3ccccc23)NC1=O,nitro
240301,Please add a hydroxyl to the molecule CCc1cc2c(CN3CCC[C@@H]3c3ccc(OC)cc3)cc(=O)oc2cc1O.,CCc1cc2c(CN3CCC[C@@H]3c3ccc(OC)cc3)cc(=O)oc2cc1O,hydroxyl
154859,Please add a benzene ring to the molecule NC(=S)Cc1ccc(S(=O)(=O)NCc2cscn2)cc1.,NC(=S)Cc1ccc(S(=O)(=O)NCc2cscn2)cc1,benzene ring
167470,Please add a halo to the molecule CCC[NH2+]C1CC(C(=O)[O-])C1.,CCC[NH2+]C1CC(C(=O)[O-])C1,halo
153194,Modify the molecule CC(C)N1CC[C@H](NC(=O)N(C)Cc2nc(C(F)(F)F)cs2)C1=O by adding a amine.,CC(C)N1CC[C@H](NC(=O)N(C)Cc2nc(C(F)(F)F)cs2)C1=O,amine
247584,Add a halo to the molecule Cc1ccc(-c2nc(NC(=O)c3nccn4ccnc34)sc2C)cc1.,Cc1ccc(-c2nc(NC(=O)c3nccn4ccnc34)sc2C)cc1,halo
28615,Please add a amide to the molecule Cn1ccs/c1=N\C(=O)C1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1.,Cn1ccs/c1=N\C(=O)C1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1,amide
187219,Please add a hydroxyl to the molecule Cn1ncnc1/N=C(\[O-])N1CCCC[C@@H]1c1nc(-c2ccccc2)no1.,Cn1ncnc1/N=C(\[O-])N1CCCC[C@@H]1c1nc(-c2ccccc2)no1,hydroxyl
85910,Modify the molecule CC1(C)C[C@H]2C[C@](C)(CN2c2cncc(/C(N)=[NH+]\NC(=S)N3CCCC3)n2)C1 by adding a carboxyl.,CC1(C)C[C@H]2C[C@](C)(CN2c2cncc(/C(N)=[NH+]\NC(=S)N3CCCC3)n2)C1,carboxyl
81486,Add a hydroxyl to the molecule CC[C@@H](NC(=O)[C@H]1CCO[C@@H]1C)c1ccc(OC(F)F)cc1.,CC[C@@H](NC(=O)[C@H]1CCO[C@@H]1C)c1ccc(OC(F)F)cc1,hydroxyl
207898,Modify the molecule C[C@H]1CCC[C@H](NC(=O)C(=O)Nc2cccc(C(=O)N3CCCC3)c2)[C@@H]1C by adding a amide.,C[C@H]1CCC[C@H](NC(=O)C(=O)Nc2cccc(C(=O)N3CCCC3)c2)[C@@H]1C,amide
127230,Add a hydroxyl to the molecule Cc1ccc(-c2nc(C#N)c(NC[C@H](c3ccccc3)[NH+](C)C)o2)cc1.,Cc1ccc(-c2nc(C#N)c(NC[C@H](c3ccccc3)[NH+](C)C)o2)cc1,hydroxyl
201567,Modify the molecule C[C@@H](C(=O)Nc1ccc(F)c(F)c1)N1CCS(=O)(=O)CC1 by adding a nitro.,C[C@@H](C(=O)Nc1ccc(F)c(F)c1)N1CCS(=O)(=O)CC1,nitro
226856,Add a benzene ring to the molecule CC[NH2+][C@@]1(CO)CCC[C@@H]([NH+](CC(C)C)C(C)C)C1.,CC[NH2+][C@@]1(CO)CCC[C@@H]([NH+](CC(C)C)C(C)C)C1,benzene ring
104150,Modify the molecule CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1 by adding a aldehyde.,CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1,aldehyde
166344,Modify the molecule Cc1cc(OCC(=O)Nc2sccc2C(=O)[O-])ccc1Cl by adding a halo.,Cc1cc(OCC(=O)Nc2sccc2C(=O)[O-])ccc1Cl,halo
190968,Please add a hydroxyl to the molecule C=CCn1c(=O)oc2ccc(C(=O)N3CCN(c4cccc[nH+]4)CC3)cc21.,C=CCn1c(=O)oc2ccc(C(=O)N3CCN(c4cccc[nH+]4)CC3)cc21,hydroxyl
159167,Please add a carboxyl to the molecule CC[C@@H]([NH2+][C@@H]1CCCCC1(C)C)c1ccc2c(c1)CCO2.,CC[C@@H]([NH2+][C@@H]1CCCCC1(C)C)c1ccc2c(c1)CCO2,carboxyl
162349,Please add a amide to the molecule O=C(CCC1CCCC1)Nc1c(C(=O)Nc2ccc([N+](=O)[O-])cc2)oc2ccccc12.,O=C(CCC1CCCC1)Nc1c(C(=O)Nc2ccc([N+](=O)[O-])cc2)oc2ccccc12,amide
49283,Add a hydroxyl to the molecule CC[NH+]1CCN([C@@H]2CC[NH+](Cc3ccco3)C2)CC1.,CC[NH+]1CCN([C@@H]2CC[NH+](Cc3ccco3)C2)CC1,hydroxyl
71787,Modify the molecule Cc1noc(C)c1[C@H](C)[NH2+][C@H](C)c1nccs1 by adding a carboxyl.,Cc1noc(C)c1[C@H](C)[NH2+][C@H](C)c1nccs1,carboxyl
231307,Please add a hydroxyl to the molecule O=C(/C=C/c1c(Cl)nc2sccn12)NCCc1cc(F)cc2c1OCOC2.,O=C(/C=C/c1c(Cl)nc2sccn12)NCCc1cc(F)cc2c1OCOC2,hydroxyl
57390,Modify the molecule CCN(CCC#N)C(=O)Cn1nnc(-c2ccsc2)n1 by adding a hydroxyl.,CCN(CCC#N)C(=O)Cn1nnc(-c2ccsc2)n1,hydroxyl
176054,Please add a carboxyl to the molecule COCc1cc(C)nc(SCC(=O)c2ccc(Cl)cc2Cl)c1C#N.,COCc1cc(C)nc(SCC(=O)c2ccc(Cl)cc2Cl)c1C#N,carboxyl
203783,Add a aldehyde to the molecule COc1ccc2c(c1)[C@](O)([C@@H]1CC[C@H](C)[C@@H](C)C1)CC2.,COc1ccc2c(c1)[C@](O)([C@@H]1CC[C@H](C)[C@@H](C)C1)CC2,aldehyde
112769,Modify the molecule O=C(Nc1ccc(CC(=O)N2CCCCC2)cc1)c1ccc(N2CCCOC2=O)cc1 by adding a halo.,O=C(Nc1ccc(CC(=O)N2CCCCC2)cc1)c1ccc(N2CCCOC2=O)cc1,halo
38565,Modify the molecule C[C@@H](C(=O)N(C)[C@H](C)c1cccnc1)n1c([S-])nnc1-c1cccs1 by adding a hydroxyl.,C[C@@H](C(=O)N(C)[C@H](C)c1cccnc1)n1c([S-])nnc1-c1cccs1,hydroxyl
159834,Add a halo to the molecule COc1ccccc1CN1CCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H]2C1.,COc1ccccc1CN1CCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H]2C1,halo
242564,Modify the molecule O=C(CSc1nnc(N2CCCC2)s1)NC[C@@H]1CCCO1 by adding a amide.,O=C(CSc1nnc(N2CCCC2)s1)NC[C@@H]1CCCO1,amide
76447,Modify the molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)C(=O)Nc1ccc2[nH]ncc2c1 by adding a benzene ring.,CC(C)C[C@@H](C[NH+](C)C)NC(=O)C(=O)Nc1ccc2[nH]ncc2c1,benzene ring
172733,Add a benzene ring to the molecule O=C(C1=NC=C(c2csc(NC[C@H]3CCCO3)n2)C1)N1CCCC1.,O=C(C1=NC=C(c2csc(NC[C@H]3CCCO3)n2)C1)N1CCCC1,benzene ring
188860,Please add a carboxyl to the molecule CC[NH+](C)C[C@@H]1CCN(C(=O)Nc2ccc3c(c2)CCO3)C1.,CC[NH+](C)C[C@@H]1CCN(C(=O)Nc2ccc3c(c2)CCO3)C1,carboxyl
25007,Add a halo to the molecule CC[NH2+][C@H]1[C@@H](C[NH+]2CC[C@H](COC)C2)CCC1(C)C.,CC[NH2+][C@H]1[C@@H](C[NH+]2CC[C@H](COC)C2)CCC1(C)C,halo
69722,Please add a thiol to the molecule COc1ccc(Cl)cc1C(=O)Nc1ccc(N2CCOCC2)cc1.,COc1ccc(Cl)cc1C(=O)Nc1ccc(N2CCOCC2)cc1,thiol
169047,Please add a carboxyl to the molecule COCCOc1ccccc1C=O.,COCCOc1ccccc1C=O,carboxyl
50669,Add a halo to the molecule COC(=O)c1ccsc1NC(=O)[C@@H](C)c1ccsc1.,COC(=O)c1ccsc1NC(=O)[C@@H](C)c1ccsc1,halo
212377,Please add a benzene ring to the molecule O=C(NC[C@@H](CCO)c1ccccc1)[C@@H]1C[C@@]12CCCc1ccccc12.,O=C(NC[C@@H](CCO)c1ccccc1)[C@@H]1C[C@@]12CCCc1ccccc12,benzene ring
192674,Add a hydroxyl to the molecule CCn1c(SCC(=O)Nc2cccc(Cl)c2)nnc1-c1cn(C)nc1OC.,CCn1c(SCC(=O)Nc2cccc(Cl)c2)nnc1-c1cn(C)nc1OC,hydroxyl
170632,Add a hydroxyl to the molecule CCN([C@@H](C)c1ccc(F)cc1)S(=O)(=O)c1cn(C)c(C)n1.,CCN([C@@H](C)c1ccc(F)cc1)S(=O)(=O)c1cn(C)c(C)n1,hydroxyl
234064,Please add a benzene ring to the molecule Cc1cc(S(C)(=O)=O)c(C)c(S(=O)(=O)N2CCO[C@H](C)C2)c1.,Cc1cc(S(C)(=O)=O)c(C)c(S(=O)(=O)N2CCO[C@H](C)C2)c1,benzene ring
28993,Modify the molecule Cc1ccc(N(CCC#N)C(=O)CSC2=N[C@H](C)CS2)cc1C by adding a aldehyde.,Cc1ccc(N(CCC#N)C(=O)CSC2=N[C@H](C)CS2)cc1C,aldehyde
44317,Add a benzene ring to the molecule C[C@@H]1CSCCN1C(=O)Cl.,C[C@@H]1CSCCN1C(=O)Cl,benzene ring
40213,Add a amide to the molecule CCc1ncc2c(n1)C[NH+](CCCS(=O)(=O)c1ccccc1)CC2.,CCc1ncc2c(n1)C[NH+](CCCS(=O)(=O)c1ccccc1)CC2,amide
236198,Add a halo to the molecule Cc1cc(C)n(CCNC(=O)CCSc2ccccc2)n1.,Cc1cc(C)n(CCNC(=O)CCSc2ccccc2)n1,halo
77475,Please add a aldehyde to the molecule COc1ccc([C@@H]2C[C@H](C)[NH+](Cc3cnc(-c4cccnc4)s3)C2)cc1.,COc1ccc([C@@H]2C[C@H](C)[NH+](Cc3cnc(-c4cccnc4)s3)C2)cc1,aldehyde
106928,Modify the molecule CC[C@H](C(=O)N(C)Cc1nc(-c2ccncc2)no1)n1cccn1 by adding a carboxyl.,CC[C@H](C(=O)N(C)Cc1nc(-c2ccncc2)no1)n1cccn1,carboxyl
104221,Add a benzene ring to the molecule CC(C)c1cnc(CN2C[C@@H](c3ccc(F)cc3)C[C@H]2C)o1.,CC(C)c1cnc(CN2C[C@@H](c3ccc(F)cc3)C[C@H]2C)o1,benzene ring
182498,Add a amide to the molecule CC[NH+](CCNC(=O)C(=O)Nc1cccc(F)c1C)C1CC1.,CC[NH+](CCNC(=O)C(=O)Nc1cccc(F)c1C)C1CC1,amide
77363,Please add a nitrile to the molecule CSC[C@@H](C)NC(=O)Nc1ccc(C)c(F)c1.,CSC[C@@H](C)NC(=O)Nc1ccc(C)c(F)c1,nitrile
28576,Add a aldehyde to the molecule CC1(C)C(=O)[C@]2(C(=O)N3CCN(C(=O)[C@@]45CC[C@@H](C4)C(C)(C)C5=O)CC3)CC[C@H]1C2.,CC1(C)C(=O)[C@]2(C(=O)N3CCN(C(=O)[C@@]45CC[C@@H](C4)C(C)(C)C5=O)CC3)CC[C@H]1C2,aldehyde
151383,Please add a amide to the molecule C[C@@H](Nc1ccc(C(N)=O)nn1)c1ccc(F)c(F)c1.,C[C@@H](Nc1ccc(C(N)=O)nn1)c1ccc(F)c(F)c1,amide
152842,Please add a benzene ring to the molecule Cc1cc(NC(=O)CCN2CCN(C(=O)[C@H]3COc4ccccc4O3)CC2)no1.,Cc1cc(NC(=O)CCN2CCN(C(=O)[C@H]3COc4ccccc4O3)CC2)no1,benzene ring
99152,Please add a carboxyl to the molecule O=C(NCC[NH+]1CCCC1)c1cccc([C@@H]2CCCN(C(=O)Nc3ccc(Cl)cc3)C2)c1.,O=C(NCC[NH+]1CCCC1)c1cccc([C@@H]2CCCN(C(=O)Nc3ccc(Cl)cc3)C2)c1,carboxyl
185032,Add a benzene ring to the molecule O=C(Nc1cccc(NC(=O)c2cccnc2Cl)c1)c1ccccc1.,O=C(Nc1cccc(NC(=O)c2cccnc2Cl)c1)c1ccccc1,benzene ring
51242,Modify the molecule CSc1ccc(C)c(/C([O-])=N/S(=O)(=O)CCCF)c1 by adding a hydroxyl.,CSc1ccc(C)c(/C([O-])=N/S(=O)(=O)CCCF)c1,hydroxyl
148202,Modify the molecule CC(C)[NH2+][C@](C)(C[NH+]1CCC(C)(C)C1)C(=O)[O-] by adding a hydroxyl.,CC(C)[NH2+][C@](C)(C[NH+]1CCC(C)(C)C1)C(=O)[O-],hydroxyl
237422,Modify the molecule Cc1ccc([C@H](C)NC(=O)CNc2ccc(F)c(C(=O)N(C)C)c2)cc1C by adding a benzene ring.,Cc1ccc([C@H](C)NC(=O)CNc2ccc(F)c(C(=O)N(C)C)c2)cc1C,benzene ring
67017,Please add a aldehyde to the molecule CC(C)N1C(N)=[NH+]C[C@]1(C)c1ccccc1OC(F)F.,CC(C)N1C(N)=[NH+]C[C@]1(C)c1ccccc1OC(F)F,aldehyde
168670,Please add a thiol to the molecule C[NH2+][C@H]1CC(C)(C)c2c(C)cc(Cl)c(C)c21.,C[NH2+][C@H]1CC(C)(C)c2c(C)cc(Cl)c(C)c21,thiol
144844,Please add a hydroxyl to the molecule CSc1ccc(NC(=O)[C@H](C)[NH+]2CCC(N3CCO[C@H](C)C3)CC2)cc1.,CSc1ccc(NC(=O)[C@H](C)[NH+]2CCC(N3CCO[C@H](C)C3)CC2)cc1,hydroxyl
193285,Add a amide to the molecule COc1ccc(N2CCC[C@H](C(=O)Nc3ccc(Cn4cncn4)cc3)C2)nn1.,COc1ccc(N2CCC[C@H](C(=O)Nc3ccc(Cn4cncn4)cc3)C2)nn1,amide
86273,Please add a amine to the molecule O=C(CCSc1ccc2c(c1)OCCCO2)NCc1ccccc1.,O=C(CCSc1ccc2c(c1)OCCCO2)NCc1ccccc1,amine
233894,Modify the molecule CC[C@H](C)n1ncc(C(=O)N2CCC(c3nc(C)no3)CC2)c1C1CC1 by adding a hydroxyl.,CC[C@H](C)n1ncc(C(=O)N2CCC(c3nc(C)no3)CC2)c1C1CC1,hydroxyl
18677,Please add a carboxyl to the molecule COc1ccc(-c2[nH+]c([C@H]3CC(=O)N(CC(C)C)C3)[nH]c2C)cc1.,COc1ccc(-c2[nH+]c([C@H]3CC(=O)N(CC(C)C)C3)[nH]c2C)cc1,carboxyl
137439,Add a amide to the molecule CC1CCN(S(=O)(=O)c2ccc(N3C[C@@H](C(=O)Nc4ccc(F)cc4)CC3=O)cc2)CC1.,CC1CCN(S(=O)(=O)c2ccc(N3C[C@@H](C(=O)Nc4ccc(F)cc4)CC3=O)cc2)CC1,amide
152864,Modify the molecule CC[C@@H](NCc1cnc(C(C)(C)C)s1)c1nc(C(F)(F)F)cs1 by adding a benzene ring.,CC[C@@H](NCc1cnc(C(C)(C)C)s1)c1nc(C(F)(F)F)cs1,benzene ring
28060,Add a nitro to the molecule Cc1ccc(C(=O)c2ccccc2C(=O)OCC(=O)NC(=O)NC(C)(C)C)cc1.,Cc1ccc(C(=O)c2ccccc2C(=O)OCC(=O)NC(=O)NC(C)(C)C)cc1,nitro
83271,Add a amine to the molecule CCC[C@@H](NC(=O)[C@@H]1CCN(C(C)=O)C1)C(=O)OC.,CCC[C@@H](NC(=O)[C@@H]1CCN(C(C)=O)C1)C(=O)OC,amine
228024,Please add a nitrile to the molecule Cc1ccc(N2C[C@@H](C(=O)N3CCC(c4nc(-c5ccc(F)cc5)no4)CC3)CC2=O)cc1C.,Cc1ccc(N2C[C@@H](C(=O)N3CCC(c4nc(-c5ccc(F)cc5)no4)CC3)CC2=O)cc1C,nitrile
125918,Please add a nitro to the molecule Cc1ccc2[nH]c(CSCC(=O)Nc3ccc(F)cc3)cc(=O)c2c1.,Cc1ccc2[nH]c(CSCC(=O)Nc3ccc(F)cc3)cc(=O)c2c1,nitro
189074,Add a hydroxyl to the molecule CC[C@@H](C)NC(=O)c1cccc(-c2ccc(N3CCOCC3)[nH+]c2)c1.,CC[C@@H](C)NC(=O)c1cccc(-c2ccc(N3CCOCC3)[nH+]c2)c1,hydroxyl
24104,Modify the molecule O=C(CC[NH+]1CC=C(c2ccc(O)cc2)CC1)Nc1cc(Cl)ccc1Cl by adding a nitro.,O=C(CC[NH+]1CC=C(c2ccc(O)cc2)CC1)Nc1cc(Cl)ccc1Cl,nitro
7271,Please add a hydroxyl to the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(-n3nccn3)cc2)C1.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(-n3nccn3)cc2)C1,hydroxyl
163306,Modify the molecule CC[NH2+][C@@H](C)c1cc(F)ccc1Sc1cccc(F)c1 by adding a amide.,CC[NH2+][C@@H](C)c1cc(F)ccc1Sc1cccc(F)c1,amide
10109,Add a halo to the molecule C[C@@H](Cc1nc2ccccc2s1)NCc1ncn(C)n1.,C[C@@H](Cc1nc2ccccc2s1)NCc1ncn(C)n1,halo
27017,Please add a amide to the molecule O=[N+]([O-])c1ccc(N2CCOCC2)c(/C=N/n2cnnc2SCc2ccccc2)c1.,O=[N+]([O-])c1ccc(N2CCOCC2)c(/C=N/n2cnnc2SCc2ccccc2)c1,amide
232330,Modify the molecule COc1c(C)cnc(C[C@]2(C[NH3+])CCC(C)(C)[C@H]2O)c1C by adding a halo.,COc1c(C)cnc(C[C@]2(C[NH3+])CCC(C)(C)[C@H]2O)c1C,halo
218425,Please add a benzene ring to the molecule CCn1nc(C)c(C[NH+]2C[C@H]3[C@@H](C2)OC(=O)N3CCc2ccccn2)c1C.,CCn1nc(C)c(C[NH+]2C[C@H]3[C@@H](C2)OC(=O)N3CCc2ccccn2)c1C,benzene ring
179762,Add a carboxyl to the molecule Cc1ccccc1[C@@H]([NH2+]CC(C)(C)NS(C)(=O)=O)C1CC1.,Cc1ccccc1[C@@H]([NH2+]CC(C)(C)NS(C)(=O)=O)C1CC1,carboxyl
236791,Please add a nitro to the molecule Cc1nnc(C[NH+]2CCC3(CC2)CC(=O)N(Cc2c(C)noc2C)C3)o1.,Cc1nnc(C[NH+]2CCC3(CC2)CC(=O)N(Cc2c(C)noc2C)C3)o1,nitro
59259,Add a hydroxyl to the molecule COc1cccc(-c2cc(C[NH2+][C@@H]3CCOC4(CCOCC4)C3)on2)c1.,COc1cccc(-c2cc(C[NH2+][C@@H]3CCOC4(CCOCC4)C3)on2)c1,hydroxyl
111143,Modify the molecule CCOC(=O)C1(C)CCN(C(=O)c2[nH]nc(C3CC3)c2Cl)CC1 by adding a hydroxyl.,CCOC(=O)C1(C)CCN(C(=O)c2[nH]nc(C3CC3)c2Cl)CC1,hydroxyl
145008,Add a amide to the molecule Cc1nn(CCCC(=O)NCc2ccccc2)c(=O)c2cc3occc3n12.,Cc1nn(CCCC(=O)NCc2ccccc2)c(=O)c2cc3occc3n12,amide
196774,Add a hydroxyl to the molecule COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O.,COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O,hydroxyl
148621,Add a benzene ring to the molecule CC1(C)CCSC[C@@]1(O)c1cccc2ccccc12.,CC1(C)CCSC[C@@]1(O)c1cccc2ccccc12,benzene ring
226696,Add a amide to the molecule C[C@@H](NC(=O)C[C@H]1CCc2ccccc21)c1noc(Cc2ccccc2)n1.,C[C@@H](NC(=O)C[C@H]1CCc2ccccc21)c1noc(Cc2ccccc2)n1,amide
127667,Modify the molecule COc1ccccc1C(=O)N[C@H]1CCS(=O)(=O)C1 by adding a amide.,COc1ccccc1C(=O)N[C@H]1CCS(=O)(=O)C1,amide
43596,Modify the molecule Cc1ccc(SCc2n[nH]c3c2[C@H](c2cccs2)C(C#N)=C(N)O3)cc1 by adding a benzene ring.,Cc1ccc(SCc2n[nH]c3c2[C@H](c2cccs2)C(C#N)=C(N)O3)cc1,benzene ring
135761,Please add a hydroxyl to the molecule C[C@H](NC[C@H]1CCCc2ccccc21)c1ccc(S(N)(=O)=O)cc1.,C[C@H](NC[C@H]1CCCc2ccccc21)c1ccc(S(N)(=O)=O)cc1,hydroxyl
89406,Add a hydroxyl to the molecule COc1cccc(-c2cc(C(=O)N3CCC[C@@H]3c3cc(C(C)C)no3)on2)c1.,COc1cccc(-c2cc(C(=O)N3CCC[C@@H]3c3cc(C(C)C)no3)on2)c1,hydroxyl
41590,Modify the molecule CN(C(=O)c1ccccc1NC(=O)[C@@H]1CCCS1)C1CCCCC1 by adding a halo.,CN(C(=O)c1ccccc1NC(=O)[C@@H]1CCCS1)C1CCCCC1,halo
8533,Modify the molecule Cc1ccc2nc(C)c(C)c(C(=O)NCC[NH+]3CCC(CO)CC3)c2c1 by adding a halo.,Cc1ccc2nc(C)c(C)c(C(=O)NCC[NH+]3CCC(CO)CC3)c2c1,halo
130654,Modify the molecule COc1ccccc1OC(=O)COc1ccc(Cl)cc1Cl by adding a benzene ring.,COc1ccccc1OC(=O)COc1ccc(Cl)cc1Cl,benzene ring
164928,Modify the molecule CCN(CC)c1ncc(CN2CCO[C@@H]3CCCC[C@@H]32)s1 by adding a amine.,CCN(CC)c1ncc(CN2CCO[C@@H]3CCCC[C@@H]32)s1,amine
58280,Modify the molecule CC[NH+](CC)[C@H](CNC(=O)Nc1cccnc1)c1ccsc1 by adding a aldehyde.,CC[NH+](CC)[C@H](CNC(=O)Nc1cccnc1)c1ccsc1,aldehyde
165516,Modify the molecule C[C@@H](NC(=O)Nc1cccc(N2CCCCCC2)c1)C(=O)NC(C)(C)C by adding a carboxyl.,C[C@@H](NC(=O)Nc1cccc(N2CCCCCC2)c1)C(=O)NC(C)(C)C,carboxyl
146903,Add a hydroxyl to the molecule O=C1C[C@@H](c2ccccc2F)c2c(n[nH]c2-c2ccccc2)N1.,O=C1C[C@@H](c2ccccc2F)c2c(n[nH]c2-c2ccccc2)N1,hydroxyl
196938,Modify the molecule COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O by adding a carboxyl.,COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O,carboxyl
199301,Add a benzene ring to the molecule C[C@@H](OC(=O)Cc1csc(N2CCNC2=O)n1)c1nccs1.,C[C@@H](OC(=O)Cc1csc(N2CCNC2=O)n1)c1nccs1,benzene ring
199914,Please add a hydroxyl to the molecule O=C(COc1ccc(Oc2ccccc2)cc1)NNC(=O)c1cccnc1.,O=C(COc1ccc(Oc2ccccc2)cc1)NNC(=O)c1cccnc1,hydroxyl
164405,Please add a amide to the molecule Cc1ccc(C)c(NC(=O)CCNc2nccc(N3CCC(O)CC3)n2)c1.,Cc1ccc(C)c(NC(=O)CCNc2nccc(N3CCC(O)CC3)n2)c1,amide
62376,Modify the molecule Cc1noc(-c2ccc(C(=O)Nc3cccn(C)c3=O)cc2)n1 by adding a hydroxyl.,Cc1noc(-c2ccc(C(=O)Nc3cccn(C)c3=O)cc2)n1,hydroxyl
121104,Add a amide to the molecule CNC(=S)n1nnc2cc(Cl)ccc21.,CNC(=S)n1nnc2cc(Cl)ccc21,amide
240489,Modify the molecule C[C@@]1(NC(=O)c2ccc([N+](=O)[O-])o2)CCS(=O)(=O)C1 by adding a benzene ring.,C[C@@]1(NC(=O)c2ccc([N+](=O)[O-])o2)CCS(=O)(=O)C1,benzene ring
68760,Please add a hydroxyl to the molecule CC(C)c1ccc(NC(=O)C(=O)NC[C@]2(O)CCc3ccccc32)cc1.,CC(C)c1ccc(NC(=O)C(=O)NC[C@]2(O)CCc3ccccc32)cc1,hydroxyl
230298,Modify the molecule C[C@@H](CNC(=O)N1CCC(NS(C)(=O)=O)CC1)[NH+]1CCC[C@@H](C)C1 by adding a benzene ring.,C[C@@H](CNC(=O)N1CCC(NS(C)(=O)=O)CC1)[NH+]1CCC[C@@H](C)C1,benzene ring
5865,Modify the molecule Oc1cccc(C[NH+](Cc2c[nH]nc2-c2cccnc2)CC2CC2)c1 by adding a hydroxyl.,Oc1cccc(C[NH+](Cc2c[nH]nc2-c2cccnc2)CC2CC2)c1,hydroxyl
114002,Please add a benzene ring to the molecule CCOC(=O)N1CCC(Nc2nc(-c3c[nH]c4ccccc34)cs2)CC1.,CCOC(=O)N1CCC(Nc2nc(-c3c[nH]c4ccccc34)cs2)CC1,benzene ring
36835,Modify the molecule C(#CCN1CCCC1)C=C(c1ccccc1)c1ccccc1 by adding a benzene ring.,C(#CCN1CCCC1)C=C(c1ccccc1)c1ccccc1,benzene ring
126356,Add a carboxyl to the molecule Cc1nn(C)cc1[C@@H](C)NC(=O)NCC1(C)Cc2ccccc2C1.,Cc1nn(C)cc1[C@@H](C)NC(=O)NCC1(C)Cc2ccccc2C1,carboxyl
25031,Please add a hydroxyl to the molecule CC[C@@H]1CCC[C@H](NS(=O)(=O)c2c[nH]c3ncccc23)C1.,CC[C@@H]1CCC[C@H](NS(=O)(=O)c2c[nH]c3ncccc23)C1,hydroxyl
143991,Add a benzene ring to the molecule O=C(/C=C/c1ccc2c(c1)OCO2)NCC#CCOc1ccccc1F.,O=C(/C=C/c1ccc2c(c1)OCO2)NCC#CCOc1ccccc1F,benzene ring
237197,Add a benzene ring to the molecule CSC[C@H]1CCN(S(=O)(=O)c2c(C)sc3ccccc23)C1.,CSC[C@H]1CCN(S(=O)(=O)c2c(C)sc3ccccc23)C1,benzene ring
205773,Modify the molecule CCC[C@H]1C[C@H]1NC(=O)c1ccnc(F)c1 by adding a amine.,CCC[C@H]1C[C@H]1NC(=O)c1ccnc(F)c1,amine
159401,Modify the molecule CN(CC1CC[NH+](C[C@@H](O)c2ccccc2)CC1)C(=O)C[C@H]1C=CCC1 by adding a benzene ring.,CN(CC1CC[NH+](C[C@@H](O)c2ccccc2)CC1)C(=O)C[C@H]1C=CCC1,benzene ring
95176,Please add a hydroxyl to the molecule Cc1n[nH]c(C)c1C[C@@H](C)C(=O)N(Cc1ccccc1)[C@H](C)c1ccccn1.,Cc1n[nH]c(C)c1C[C@@H](C)C(=O)N(Cc1ccccc1)[C@H](C)c1ccccn1,hydroxyl
125112,Add a amide to the molecule CCn1cc(CC(=O)N[C@H](CO)c2ccco2)c2ccccc21.,CCn1cc(CC(=O)N[C@H](CO)c2ccco2)c2ccccc21,amide
3560,Please add a halo to the molecule CC[C@@H](C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1CCCc1ccccc1.,CC[C@@H](C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1CCCc1ccccc1,halo
232546,Please add a carboxyl to the molecule CN(Cc1cc(Br)ccc1F)C(=O)C[C@@H](O)c1ccccc1.,CN(Cc1cc(Br)ccc1F)C(=O)C[C@@H](O)c1ccccc1,carboxyl
158200,Please add a amide to the molecule Cc1ccc2ncc(C(=O)N[C@H]3CCO[C@@]4(CCSC4)C3)n2c1.,Cc1ccc2ncc(C(=O)N[C@H]3CCO[C@@]4(CCSC4)C3)n2c1,amide
51132,Modify the molecule COc1ccccc1C[C@@H](C)CC(=O)N1CCC[C@@H](n2cncn2)C1 by adding a benzene ring.,COc1ccccc1C[C@@H](C)CC(=O)N1CCC[C@@H](n2cncn2)C1,benzene ring
84263,Please add a hydroxyl to the molecule CCOc1ccc(COc2ccccc2OC)nc1.,CCOc1ccc(COc2ccccc2OC)nc1,hydroxyl
151570,Modify the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)OCc1cccnc1 by adding a benzene ring.,Cc1nc2c(cnn2C(C)C)cc1C(=O)OCc1cccnc1,benzene ring
107063,Modify the molecule CCOC(=O)c1cc(-c2ccc(C)c(C)c2)n(-c2ccc(C(=O)N3CCCCC3)cc2)n1 by adding a hydroxyl.,CCOC(=O)c1cc(-c2ccc(C)c(C)c2)n(-c2ccc(C(=O)N3CCCCC3)cc2)n1,hydroxyl
63785,Please add a aldehyde to the molecule N#Cc1ccc(C(=O)N[C@@H](CO)c2ccccc2F)[n-]1.,N#Cc1ccc(C(=O)N[C@@H](CO)c2ccccc2F)[n-]1,aldehyde
156744,Please add a hydroxyl to the molecule COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1.,COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1,hydroxyl
226107,Modify the molecule CC[C@H](C)NC(=O)CN(C)S(=O)(=O)c1ccc2ccccc2c1 by adding a amide.,CC[C@H](C)NC(=O)CN(C)S(=O)(=O)c1ccc2ccccc2c1,amide
2539,Please add a carboxyl to the molecule C=C(C)Cn1ccc(-c2ccsc2)n1.,C=C(C)Cn1ccc(-c2ccsc2)n1,carboxyl
14427,Please add a aldehyde to the molecule Cc1nccn1-c1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1.,Cc1nccn1-c1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1,aldehyde
53284,Modify the molecule CCC(=O)Nc1ccc(S(=O)(=O)NC2CCC(C)CC2)cc1 by adding a hydroxyl.,CCC(=O)Nc1ccc(S(=O)(=O)NC2CCC(C)CC2)cc1,hydroxyl
196152,Add a hydroxyl to the molecule Cc1nc(C[NH+]2CCN(Cc3cc(C)n(-c4nccs4)c3C)CC2)no1.,Cc1nc(C[NH+]2CCN(Cc3cc(C)n(-c4nccs4)c3C)CC2)no1,hydroxyl
78154,Modify the molecule CCN(C)C(=O)[C@H]1CSCN1C(=O)c1ccc(F)c(F)c1F by adding a hydroxyl.,CCN(C)C(=O)[C@H]1CSCN1C(=O)c1ccc(F)c(F)c1F,hydroxyl
44954,Modify the molecule Cc1nn(C)c(N2CCN(C(=O)[C@H]3CCCO3)CC2)c1[N+](=O)[O-] by adding a hydroxyl.,Cc1nn(C)c(N2CCN(C(=O)[C@H]3CCCO3)CC2)c1[N+](=O)[O-],hydroxyl
68426,Add a amine to the molecule Cc1ccc(C)c(NC(=O)C(=O)NCC2CCN(c3ncccn3)CC2)c1.,Cc1ccc(C)c(NC(=O)C(=O)NCC2CCN(c3ncccn3)CC2)c1,amine
221567,Please add a nitrile to the molecule C#CCC[C@H](O)[C@](C)(CC)[NH+]1CCCC1.,C#CCC[C@H](O)[C@](C)(CC)[NH+]1CCCC1,nitrile
54595,Add a hydroxyl to the molecule Cc1cc(NC(=O)C[NH+](C)C[C@@H]2CCCO2)no1.,Cc1cc(NC(=O)C[NH+](C)C[C@@H]2CCCO2)no1,hydroxyl
202541,Please add a halo to the molecule Cc1ccc(NC(=O)NC(=O)COc2ccc3c4c(c(=O)oc3c2)CCC4)c(C)c1.,Cc1ccc(NC(=O)NC(=O)COc2ccc3c4c(c(=O)oc3c2)CCC4)c(C)c1,halo
2037,Please add a aldehyde to the molecule CC(C)C[C@@H]1C(=N)NC(=O)N1CC1CC1.,CC(C)C[C@@H]1C(=N)NC(=O)N1CC1CC1,aldehyde
194537,Modify the molecule Cc1ccc(C(=O)N2C[C@H](C)C[C@@H](C)C2)cc1NC(=O)c1cccnc1 by adding a halo.,Cc1ccc(C(=O)N2C[C@H](C)C[C@@H](C)C2)cc1NC(=O)c1cccnc1,halo
210600,Add a hydroxyl to the molecule C[NH+](CC(=O)N[C@@](C)(C#N)C1CC1)Cc1ccc(F)c(F)c1.,C[NH+](CC(=O)N[C@@](C)(C#N)C1CC1)Cc1ccc(F)c(F)c1,hydroxyl
156434,Add a amide to the molecule CCOC(=O)C1=C(NC(=O)NC(=O)c2ccccc2)c2ccccc2CC12CCCCC2.,CCOC(=O)C1=C(NC(=O)NC(=O)c2ccccc2)c2ccccc2CC12CCCCC2,amide
100788,Modify the molecule CCOC(=O)c1csc(-c2ccccc2Cl)n1 by adding a amine.,CCOC(=O)c1csc(-c2ccccc2Cl)n1,amine
59392,Modify the molecule C[C@@H](Cc1ccccc1)[NH2+][C@H]1CCOC2(CCCCC2)C1 by adding a hydroxyl.,C[C@@H](Cc1ccccc1)[NH2+][C@H]1CCOC2(CCCCC2)C1,hydroxyl
38855,Add a hydroxyl to the molecule Cc1ccc(-n2c(C)cc(/C=N\NC(=O)CN3CCOCC3)c2C)cc1[N+](=O)[O-].,Cc1ccc(-n2c(C)cc(/C=N\NC(=O)CN3CCOCC3)c2C)cc1[N+](=O)[O-],hydroxyl
155342,Add a benzene ring to the molecule C[C@@H]1CC(=O)CC[C@@H]1C(=O)N[C@@H](c1cccc(C(F)(F)F)c1)C1CC1.,C[C@@H]1CC(=O)CC[C@@H]1C(=O)N[C@@H](c1cccc(C(F)(F)F)c1)C1CC1,benzene ring
214672,Add a benzene ring to the molecule Cc1cn(CC(=O)Nc2cccc(-c3ccc(=O)[nH]n3)c2)c2ccccc12.,Cc1cn(CC(=O)Nc2cccc(-c3ccc(=O)[nH]n3)c2)c2ccccc12,benzene ring
53930,Add a benzene ring to the molecule CSc1ccc(/C=N/NC(=O)CCCc2ccccc2)cc1.,CSc1ccc(/C=N/NC(=O)CCCc2ccccc2)cc1,benzene ring
57866,Add a aldehyde to the molecule COC(=O)c1ccc(CN(C)C(=O)C[NH+]2CCS[C@H](C(C)C)C2)cc1.,COC(=O)c1ccc(CN(C)C(=O)C[NH+]2CCS[C@H](C(C)C)C2)cc1,aldehyde
95800,Modify the molecule CS(=O)(=O)CC(=O)N[C@@H]1CC[NH2+]C1 by adding a benzene ring.,CS(=O)(=O)CC(=O)N[C@@H]1CC[NH2+]C1,benzene ring
20299,Please add a nitro to the molecule c1ccc(OCc2nc(CNc3cnn(-c4ncccn4)c3)cs2)cc1.,c1ccc(OCc2nc(CNc3cnn(-c4ncccn4)c3)cs2)cc1,nitro
199158,Modify the molecule CC(C)Sc1nnc2ccc(-c3cccnc3)nn12 by adding a amine.,CC(C)Sc1nnc2ccc(-c3cccnc3)nn12,amine
150784,Please add a amide to the molecule CCCCC(=O)c1cc(C)c(C)cc1C.,CCCCC(=O)c1cc(C)c(C)cc1C,amide
49788,Please add a amide to the molecule C[C@]1(C(=O)c2ccc3ccccc3c2)CCCO1.,C[C@]1(C(=O)c2ccc3ccccc3c2)CCCO1,amide
21115,Please add a hydroxyl to the molecule CC[NH2+][C@H](C)c1cccc(OCC[NH+](C)C)c1.,CC[NH2+][C@H](C)c1cccc(OCC[NH+](C)C)c1,hydroxyl
21909,Modify the molecule O=C(Nc1ccc2c(c1)COC2)[C@@H]1CSc2ccccc21 by adding a amide.,O=C(Nc1ccc2c(c1)COC2)[C@@H]1CSc2ccccc21,amide
191881,Add a benzene ring to the molecule COc1ccccc1[C@]1(CC(=O)N2C[C@@]3(C)C[C@@H]2CC(C)(C)C3)CC(=O)N(C2CCCC2)C1=O.,COc1ccccc1[C@]1(CC(=O)N2C[C@@]3(C)C[C@@H]2CC(C)(C)C3)CC(=O)N(C2CCCC2)C1=O,benzene ring
79710,Modify the molecule Cc1ccc(S(=O)(=O)c2cc3c(cc2NC(=O)COc2ccc(F)cc2)n(C)c(=O)n3C)cc1 by adding a aldehyde.,Cc1ccc(S(=O)(=O)c2cc3c(cc2NC(=O)COc2ccc(F)cc2)n(C)c(=O)n3C)cc1,aldehyde
198852,Add a carboxyl to the molecule CCOc1c(CN2C[C@H]3CCC[NH+]3C[C@@H]2C)c(C)nn1CC(C)C.,CCOc1c(CN2C[C@H]3CCC[NH+]3C[C@@H]2C)c(C)nn1CC(C)C,carboxyl
137925,Please add a hydroxyl to the molecule Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1.,Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1,hydroxyl
38216,Modify the molecule COc1nc(N2CCN(C(=O)C3CCC3)CC2)ncc1Br by adding a amine.,COc1nc(N2CCN(C(=O)C3CCC3)CC2)ncc1Br,amine
54475,Add a amide to the molecule CC[C@H](CC(=O)NNC(=O)[C@@H]1CCS(=O)(=O)C1)c1ccc(C)cc1.,CC[C@H](CC(=O)NNC(=O)[C@@H]1CCS(=O)(=O)C1)c1ccc(C)cc1,amide
168526,Please add a carboxyl to the molecule COc1ccc([C@H]2Oc3ccccc3C3=Nc4ncnn4[C@@H](c4ccccc4F)[C@H]32)cc1OC.,COc1ccc([C@H]2Oc3ccccc3C3=Nc4ncnn4[C@@H](c4ccccc4F)[C@H]32)cc1OC,carboxyl
182054,Please add a benzene ring to the molecule CC[C@H](C(=O)N1CC[C@@H](O)C1)c1cccc(C(F)(F)F)c1.,CC[C@H](C(=O)N1CC[C@@H](O)C1)c1cccc(C(F)(F)F)c1,benzene ring
134161,Modify the molecule O=c1ccc2ccc(OC3CC[NH2+]CC3)cc2o1 by adding a amide.,O=c1ccc2ccc(OC3CC[NH2+]CC3)cc2o1,amide
108855,Add a benzene ring to the molecule Fc1nc(F)c(F)c(NCc2nncn2C2CC2)c1F.,Fc1nc(F)c(F)c(NCc2nncn2C2CC2)c1F,benzene ring
20774,Add a benzene ring to the molecule CC[NH2+][C@@H](C[C@@H]1CCCO1)[C@@H]1CCC[C@H](S(C)(=O)=O)C1.,CC[NH2+][C@@H](C[C@@H]1CCCO1)[C@@H]1CCC[C@H](S(C)(=O)=O)C1,benzene ring
107746,Modify the molecule COc1cc(/C=C2/C(=O)NN(c3ccccc3)C2=O)c(Br)c(Br)c1[O-] by adding a amide.,COc1cc(/C=C2/C(=O)NN(c3ccccc3)C2=O)c(Br)c(Br)c1[O-],amide
143463,Modify the molecule CC[C@@H]1CCC[NH+]1[C@@H]1CCc2ccc(OC)cc2[C@@H]1O by adding a halo.,CC[C@@H]1CCC[NH+]1[C@@H]1CCc2ccc(OC)cc2[C@@H]1O,halo
204637,Modify the molecule O=C(Nc1cc(Cl)ccc1Cl)[C@H]1Cc2ccccc2O/C1=N\O by adding a halo.,O=C(Nc1cc(Cl)ccc1Cl)[C@H]1Cc2ccccc2O/C1=N\O,halo
86448,Please add a benzene ring to the molecule O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1.,O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1,benzene ring
56626,Add a hydroxyl to the molecule C[C@@H](CNCc1c(F)cccc1Cl)[NH+]1CCCC1.,C[C@@H](CNCc1c(F)cccc1Cl)[NH+]1CCCC1,hydroxyl
217310,Add a amine to the molecule COc1cc([C@@H]2C(C#N)=C(N)Oc3c2oc(CO)cc3=O)c(OC)c2c1OCO2.,COc1cc([C@@H]2C(C#N)=C(N)Oc3c2oc(CO)cc3=O)c(OC)c2c1OCO2,amine
206981,Add a carboxyl to the molecule N#CCc1noc2cc([N+](=O)[O-])ccc12.,N#CCc1noc2cc([N+](=O)[O-])ccc12,carboxyl
164481,Modify the molecule CN1C(=O)/C(=N\Nc2ccc(Cl)cc2Cl)c2ccccc21 by adding a benzene ring.,CN1C(=O)/C(=N\Nc2ccc(Cl)cc2Cl)c2ccccc21,benzene ring
52483,Add a hydroxyl to the molecule CC(=O)c1ccc(NC(=O)CCNC(=O)N(C)Cc2ccccc2)cc1C.,CC(=O)c1ccc(NC(=O)CCNC(=O)N(C)Cc2ccccc2)cc1C,hydroxyl
236245,Add a carboxyl to the molecule CCC(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc3[C@@H]2CC(=O)NC2CCCCC2)cc1.,CCC(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc3[C@@H]2CC(=O)NC2CCCCC2)cc1,carboxyl
232622,Please add a benzene ring to the molecule CCN(CC)C(=O)CCC(=O)Nc1cccc(-n2nc(C)cc2C)c1.,CCN(CC)C(=O)CCC(=O)Nc1cccc(-n2nc(C)cc2C)c1,benzene ring
29994,Modify the molecule CCc1cc(=O)[nH]c(-c2ccc(N[C@@H]3CCN(C(=O)OC)C3)nc2)n1 by adding a aldehyde.,CCc1cc(=O)[nH]c(-c2ccc(N[C@@H]3CCN(C(=O)OC)C3)nc2)n1,aldehyde
105866,Please add a hydroxyl to the molecule O=C(Nc1ccc(N2CCCCC2)cc1)c1csc(-c2ncccn2)n1.,O=C(Nc1ccc(N2CCCCC2)cc1)c1csc(-c2ncccn2)n1,hydroxyl
34851,Add a benzene ring to the molecule Cc1cccc(NC(=O)CSC2=C(C#N)[C@@H](c3ccco3)C3=C([O-])CCCC3=N2)c1.,Cc1cccc(NC(=O)CSC2=C(C#N)[C@@H](c3ccco3)C3=C([O-])CCCC3=N2)c1,benzene ring
27406,Modify the molecule C[C@@H]1CC[C@@H](C)[NH+]1CCN1CCN(Cc2cc(O)ccc2[N+](=O)[O-])CC1 by adding a benzene ring.,C[C@@H]1CC[C@@H](C)[NH+]1CCN1CCN(Cc2cc(O)ccc2[N+](=O)[O-])CC1,benzene ring
116508,Please add a hydroxyl to the molecule C[C@@]1(c2cc(F)ccc2F)NC(=O)N(CC(=O)C2=NC=CC2)C1=O.,C[C@@]1(c2cc(F)ccc2F)NC(=O)N(CC(=O)C2=NC=CC2)C1=O,hydroxyl
103229,Modify the molecule CCSc1cncc(N(C)C[C@H](C)O)n1 by adding a aldehyde.,CCSc1cncc(N(C)C[C@H](C)O)n1,aldehyde
215409,Modify the molecule Cc1ccc(NC(=O)Cn2cc(I)c(=O)c(I)c2)cc1 by adding a aldehyde.,Cc1ccc(NC(=O)Cn2cc(I)c(=O)c(I)c2)cc1,aldehyde
58897,Modify the molecule C[C@H]1CN(C(=O)c2ccc(CNC(=O)[C@@H](C)[NH+]3CCCCCC3)cc2)C[C@H](C)O1 by adding a amide.,C[C@H]1CN(C(=O)c2ccc(CNC(=O)[C@@H](C)[NH+]3CCCCCC3)cc2)C[C@H](C)O1,amide
171888,Modify the molecule CCOc1cc2c(cc1NC(=O)c1cnn(C(C)C)c1C)O[C@H](C)C2 by adding a hydroxyl.,CCOc1cc2c(cc1NC(=O)c1cnn(C(C)C)c1C)O[C@H](C)C2,hydroxyl
15122,Add a benzene ring to the molecule COc1ccccc1-n1nc(C(C)C)nc1CCc1cccnc1.,COc1ccccc1-n1nc(C(C)C)nc1CCc1cccnc1,benzene ring
87190,Modify the molecule CC[C@](C)([NH3+])C(=O)Nc1cc(Cl)cc(Br)c1OC by adding a benzene ring.,CC[C@](C)([NH3+])C(=O)Nc1cc(Cl)cc(Br)c1OC,benzene ring
18645,Add a amide to the molecule Cc1cc(N2CCCCC2)cc(=O)o1.,Cc1cc(N2CCCCC2)cc(=O)o1,amide
249196,Add a amine to the molecule Cc1nn(-c2ccccc2)cc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1.,Cc1nn(-c2ccccc2)cc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1,amine
180882,Please add a hydroxyl to the molecule CN(C)c1nc(N)nc(COC(=O)c2cc3ccccc3c(=O)[nH]2)n1.,CN(C)c1nc(N)nc(COC(=O)c2cc3ccccc3c(=O)[nH]2)n1,hydroxyl
70100,Modify the molecule CN(Cc1ccccc1O)C(=O)CSCc1cccnc1 by adding a carboxyl.,CN(Cc1ccccc1O)C(=O)CSCc1cccnc1,carboxyl
117240,Modify the molecule CCOc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nn2cnnc2)cc1 by adding a carboxyl.,CCOc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nn2cnnc2)cc1,carboxyl
99325,Modify the molecule Cc1nsc(N(C)C(=O)[C@@H]2CC(=O)N(C)C2)c1C(=O)[O-] by adding a hydroxyl.,Cc1nsc(N(C)C(=O)[C@@H]2CC(=O)N(C)C2)c1C(=O)[O-],hydroxyl
189041,Please add a amide to the molecule CCCNC(=O)c1cc(=O)n(CC(=O)Nc2ccc(C)c(C)c2)c2ccccc12.,CCCNC(=O)c1cc(=O)n(CC(=O)Nc2ccc(C)c(C)c2)c2ccccc12,amide
214489,Modify the molecule COC(=O)c1cccc(CC(=O)Nc2cc(C(C)C)n[nH]2)c1 by adding a amide.,COC(=O)c1cccc(CC(=O)Nc2cc(C(C)C)n[nH]2)c1,amide
15850,Add a hydroxyl to the molecule CN(C[C@H]1CCC[NH+]1C)C(=O)N1CCCCC[C@@H]1C(=O)[O-].,CN(C[C@H]1CCC[NH+]1C)C(=O)N1CCCCC[C@@H]1C(=O)[O-],hydroxyl
94414,Please add a amide to the molecule Cn1c(-n2ncc(N(CCO)Cc3ccccc3)c(Cl)c2=O)nc2ccccc21.,Cn1c(-n2ncc(N(CCO)Cc3ccccc3)c(Cl)c2=O)nc2ccccc21,amide
199348,Modify the molecule O=C([O-])C[C@@H]1CN(C[C@H]2CCOC2)CCO1 by adding a aldehyde.,O=C([O-])C[C@@H]1CN(C[C@H]2CCOC2)CCO1,aldehyde
237233,Add a hydroxyl to the molecule O=C(/C=C/c1c(Cl)cccc1Cl)N1CCC[C@H](c2[nH]cc[nH+]2)C1.,O=C(/C=C/c1c(Cl)cccc1Cl)N1CCC[C@H](c2[nH]cc[nH+]2)C1,hydroxyl
85314,Modify the molecule C[C@@H](Nc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)NC(=O)NC1CC1 by adding a benzene ring.,C[C@@H](Nc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)NC(=O)NC1CC1,benzene ring
215970,Please add a amine to the molecule COC(=O)[C@@]1(F)CCN(C(=O)Cc2cccc(O)c2)C1.,COC(=O)[C@@]1(F)CCN(C(=O)Cc2cccc(O)c2)C1,amine
70103,Add a carboxyl to the molecule COCCn1cc(Nc2nn3c(C(F)(F)F)nnc3c(C)c2C)cn1.,COCCn1cc(Nc2nn3c(C(F)(F)F)nnc3c(C)c2C)cn1,carboxyl
209697,Modify the molecule CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O by adding a benzene ring.,CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O,benzene ring
164378,Please add a benzene ring to the molecule Cc1sc(NC(=O)C2CC2)c(C(=O)N2CC[C@H](Nc3ccccc3)C2)c1C.,Cc1sc(NC(=O)C2CC2)c(C(=O)N2CC[C@H](Nc3ccccc3)C2)c1C,benzene ring
20446,Modify the molecule Cc1ccccc1[C@H]1CN(C(=O)NCc2cccc(OCC(F)F)n2)CCO1 by adding a hydroxyl.,Cc1ccccc1[C@H]1CN(C(=O)NCc2cccc(OCC(F)F)n2)CCO1,hydroxyl
131820,Add a carboxyl to the molecule COc1ccc(C[NH2+][C@@H](C)CO)c(OC)c1.,COc1ccc(C[NH2+][C@@H](C)CO)c(OC)c1,carboxyl
65907,Modify the molecule C[C@H]1C[C@@H](C)CN(S(=O)(=O)N(CCC#N)Cc2ccccn2)C1 by adding a hydroxyl.,C[C@H]1C[C@@H](C)CN(S(=O)(=O)N(CCC#N)Cc2ccccn2)C1,hydroxyl
32808,Add a amide to the molecule COc1ccc(NC(=O)CC[NH+]2CCN(c3nccs3)CC2)cc1.,COc1ccc(NC(=O)CC[NH+]2CCN(c3nccs3)CC2)cc1,amide
230428,Modify the molecule CN(C)C(=O)[C@@H]1CC[C@@H](CNc2ccc(C#N)cc2C(F)(F)F)O1 by adding a benzene ring.,CN(C)C(=O)[C@@H]1CC[C@@H](CNc2ccc(C#N)cc2C(F)(F)F)O1,benzene ring
102956,Add a nitro to the molecule O=C([O-])CNS(=O)(=O)c1ccc2[nH]c(=O)cnc2c1.,O=C([O-])CNS(=O)(=O)c1ccc2[nH]c(=O)cnc2c1,nitro
5528,Add a benzene ring to the molecule [NH3+][C@H](c1ccc(Cl)cn1)[C@H]1CCc2cccnc21.,[NH3+][C@H](c1ccc(Cl)cn1)[C@H]1CCc2cccnc21,benzene ring
23547,Modify the molecule C[C@H]1C[NH2+]CC[C@H]1NC(=O)c1c(F)cccc1F by adding a amide.,C[C@H]1C[NH2+]CC[C@H]1NC(=O)c1c(F)cccc1F,amide
169563,Add a halo to the molecule Cc1csc([C@H](C)NC(=O)N[C@H](C)c2oc3ccc(F)cc3c2C)n1.,Cc1csc([C@H](C)NC(=O)N[C@H](C)c2oc3ccc(F)cc3c2C)n1,halo
94436,Please add a benzene ring to the molecule Oc1cc(Br)c(O)cc1Br.,Oc1cc(Br)c(O)cc1Br,benzene ring
171848,Please add a hydroxyl to the molecule Cc1nnnn1/C(=C\c1ccccc1)C(=O)N[C@H]1CC[NH+]2CCCC[C@H]12.,Cc1nnnn1/C(=C\c1ccccc1)C(=O)N[C@H]1CC[NH+]2CCCC[C@H]12,hydroxyl
94211,Please add a hydroxyl to the molecule CN(C)C(=O)CCN1C(=O)c2ccccc2C1=O.,CN(C)C(=O)CCN1C(=O)c2ccccc2C1=O,hydroxyl
156452,Please add a hydroxyl to the molecule CC(C)(C)C1CCC(C#N)CC1.,CC(C)(C)C1CCC(C#N)CC1,hydroxyl
11769,Modify the molecule O=c1c2ccccc2nc(SCc2cccnc2)n1C1CCCCC1 by adding a aldehyde.,O=c1c2ccccc2nc(SCc2cccnc2)n1C1CCCCC1,aldehyde
131273,Add a carboxyl to the molecule O=C(N[C@@H]1CC[NH2+]C2(CCC2)C1)[C@@H]1CSc2ccccc21.,O=C(N[C@@H]1CC[NH2+]C2(CCC2)C1)[C@@H]1CSc2ccccc21,carboxyl
136441,Please add a hydroxyl to the molecule O=C([O-])[C@@]1([C@@H]2CCO[C@@]3(CCOC3)C2)CCOC1.,O=C([O-])[C@@]1([C@@H]2CCO[C@@]3(CCOC3)C2)CCOC1,hydroxyl
9007,Add a aldehyde to the molecule Nc1ccccc1OCC(=O)c1ccc2c(c1)OCO2.,Nc1ccccc1OCC(=O)c1ccc2c(c1)OCO2,aldehyde
174240,Add a amide to the molecule C[NH+](C)Cc1ccc(C(=O)N2CCC[C@@H]3CCCC[C@@H]32)cc1.,C[NH+](C)Cc1ccc(C(=O)N2CCC[C@@H]3CCCC[C@@H]32)cc1,amide
243248,Please add a halo to the molecule Cc1cc(NC(=O)[C@H](C)SCC(=O)Nc2ccccc2-c2nc3ccccc3s2)no1.,Cc1cc(NC(=O)[C@H](C)SCC(=O)Nc2ccccc2-c2nc3ccccc3s2)no1,halo
43130,Modify the molecule C[C@@H]1CN(S(=O)(=O)c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)C[C@@H](C)O1 by adding a carboxyl.,C[C@@H]1CN(S(=O)(=O)c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)C[C@@H](C)O1,carboxyl
4107,Please add a hydroxyl to the molecule Cc1nc(C[C@H](N)c2ccc3nccnc3c2)sc1C.,Cc1nc(C[C@H](N)c2ccc3nccnc3c2)sc1C,hydroxyl
118030,Modify the molecule Cc1ccc(S(=O)(=O)N(C)Cc2[nH+]ccn2C)cc1[N+](=O)[O-] by adding a hydroxyl.,Cc1ccc(S(=O)(=O)N(C)Cc2[nH+]ccn2C)cc1[N+](=O)[O-],hydroxyl
59852,Modify the molecule C[C@H](NC(=O)N[C@H](C)c1ccc2c(c1)OCCO2)c1nc(C(C)(C)C)no1 by adding a amide.,C[C@H](NC(=O)N[C@H](C)c1ccc2c(c1)OCCO2)c1nc(C(C)(C)C)no1,amide
120603,Modify the molecule CCONC(=O)C1CCCCC1 by adding a halo.,CCONC(=O)C1CCCCC1,halo
129748,Modify the molecule CC(C)[C@H](/N=C1\C(=O)C(=O)[C@H]1N1CCCC1)C(=O)[O-] by adding a benzene ring.,CC(C)[C@H](/N=C1\C(=O)C(=O)[C@H]1N1CCCC1)C(=O)[O-],benzene ring
28578,Add a halo to the molecule CC1CCC(N(C)C(=O)CCCn2cncn2)CC1.,CC1CCC(N(C)C(=O)CCCn2cncn2)CC1,halo
36328,Modify the molecule COc1ccc(NC(=O)C2CC2)cc1-n1cnnn1 by adding a amide.,COc1ccc(NC(=O)C2CC2)cc1-n1cnnn1,amide
132072,Modify the molecule O=C(Nc1ccccc1[N+](=O)[O-])c1cccc(S(=O)(=O)Nc2ccc(F)cc2)c1 by adding a amide.,O=C(Nc1ccccc1[N+](=O)[O-])c1cccc(S(=O)(=O)Nc2ccc(F)cc2)c1,amide
27073,Modify the molecule C[C@H](Oc1ccc(C#N)cc1)C(=O)Nc1ccccc1-c1ncc[nH]1 by adding a amide.,C[C@H](Oc1ccc(C#N)cc1)C(=O)Nc1ccccc1-c1ncc[nH]1,amide
42410,Please add a aldehyde to the molecule COc1cccc(C(=O)N[C@@H](c2ccco2)c2c(O)ccc3ccccc23)c1.,COc1cccc(C(=O)N[C@@H](c2ccco2)c2c(O)ccc3ccccc23)c1,aldehyde
16416,Please add a carboxyl to the molecule CCc1ccc(C(=O)Nc2cc(-c3nn4cnnc4s3)ccc2OC)cc1.,CCc1ccc(C(=O)Nc2cc(-c3nn4cnnc4s3)ccc2OC)cc1,carboxyl
97496,Modify the molecule CCCCCCO[C@@H]1CCCC(C)(C)[C@H]1[NH2+]C by adding a hydroxyl.,CCCCCCO[C@@H]1CCCC(C)(C)[C@H]1[NH2+]C,hydroxyl
78874,Modify the molecule C[C@H](CNC(=O)c1cccc(C[NH+](C)C)c1)Oc1ccc(Cl)cc1 by adding a hydroxyl.,C[C@H](CNC(=O)c1cccc(C[NH+](C)C)c1)Oc1ccc(Cl)cc1,hydroxyl
100527,Modify the molecule CCc1ccc([C@@H](C)C(=O)NN2C(=O)N[C@](C)(c3ccccc3)C2=O)cc1 by adding a benzene ring.,CCc1ccc([C@@H](C)C(=O)NN2C(=O)N[C@](C)(c3ccccc3)C2=O)cc1,benzene ring
58453,Modify the molecule CC(C)([C@H](O)c1ccccc1Cl)[NH+]1CCCCC1 by adding a carboxyl.,CC(C)([C@H](O)c1ccccc1Cl)[NH+]1CCCCC1,carboxyl
11344,Please add a carboxyl to the molecule Cc1cccc([C@@H](CC(F)(F)F)C(=O)[O-])c1.,Cc1cccc([C@@H](CC(F)(F)F)C(=O)[O-])c1,carboxyl
149139,Modify the molecule CC(=O)NCCNC(=O)N[C@H](C)c1nc(C)cs1 by adding a carboxyl.,CC(=O)NCCNC(=O)N[C@H](C)c1nc(C)cs1,carboxyl
34781,Modify the molecule CC[NH+]1CCc2c(cccc2NC(=O)N2CCN(CCOC)C(=O)C2)C1 by adding a amine.,CC[NH+]1CCc2c(cccc2NC(=O)N2CCN(CCOC)C(=O)C2)C1,amine
29364,Please add a carboxyl to the molecule C[C@H]1C[C@H](c2ccc(F)cc2)C[NH+]1Cc1cnc(N(C)C)s1.,C[C@H]1C[C@H](c2ccc(F)cc2)C[NH+]1Cc1cnc(N(C)C)s1,carboxyl
78129,Modify the molecule CCC1(CC)[C@@H](NC(=O)N2CCO[C@H](c3nccs3)C2)[C@H](C)[C@@H]1OC by adding a amine.,CCC1(CC)[C@@H](NC(=O)N2CCO[C@H](c3nccs3)C2)[C@H](C)[C@@H]1OC,amine
85450,Modify the molecule CC(C)CNC(=O)N(C)CCOc1ccc(Cl)cc1 by adding a carboxyl.,CC(C)CNC(=O)N(C)CCOc1ccc(Cl)cc1,carboxyl
28447,Add a benzene ring to the molecule C[C@@H](NC(=O)c1ccccc1[N+](=O)[O-])c1ccc(NC(=O)C2CC2)cc1.,C[C@@H](NC(=O)c1ccccc1[N+](=O)[O-])c1ccc(NC(=O)C2CC2)cc1,benzene ring
142896,Modify the molecule CC(C)n1nccc1C(=O)Nc1nnc(-c2cc(Cl)sc2Cl)o1 by adding a amine.,CC(C)n1nccc1C(=O)Nc1nnc(-c2cc(Cl)sc2Cl)o1,amine
64658,Please add a nitro to the molecule NS(=O)(=O)c1ccc(C(=O)NCc2ccc(N3CCCC3)[nH+]c2)cc1.,NS(=O)(=O)c1ccc(C(=O)NCc2ccc(N3CCCC3)[nH+]c2)cc1,nitro
233036,Modify the molecule O=C(NC[C@@H](O)C1CCCC1)N[C@H]1CC=CCC1 by adding a aldehyde.,O=C(NC[C@@H](O)C1CCCC1)N[C@H]1CC=CCC1,aldehyde
45195,Please add a nitro to the molecule COc1cccc(F)c1C(=O)N1CCO[C@H](C#N)C1.,COc1cccc(F)c1C(=O)N1CCO[C@H](C#N)C1,nitro
214175,Please add a hydroxyl to the molecule CN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1cccc(Cl)c1.,CN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1cccc(Cl)c1,hydroxyl
39207,Please add a amine to the molecule N#Cc1ccc(Oc2cccc(NC(=O)[C@@H]3COc4ccccc43)c2)nc1.,N#Cc1ccc(Oc2cccc(NC(=O)[C@@H]3COc4ccccc43)c2)nc1,amine
231617,Add a benzene ring to the molecule CC(C)n1ncnc1C[C@@H](C[NH3+])c1ccccc1Br.,CC(C)n1ncnc1C[C@@H](C[NH3+])c1ccccc1Br,benzene ring
26563,Modify the molecule Cc1cc(N)c(S(=O)(=O)NC[C@@H]2CN(C)CCO2)cc1C by adding a carboxyl.,Cc1cc(N)c(S(=O)(=O)NC[C@@H]2CN(C)CCO2)cc1C,carboxyl
39380,Add a nitro to the molecule O=C(c1[nH]nc(C2CC2)c1Cl)N1CC[C@@H]1c1ccc(Cl)cc1.,O=C(c1[nH]nc(C2CC2)c1Cl)N1CC[C@@H]1c1ccc(Cl)cc1,nitro
31829,Please add a amide to the molecule CCCNC(=O)NC(=O)C[NH+](CC1CC[NH2+]CC1)C(C)C.,CCCNC(=O)NC(=O)C[NH+](CC1CC[NH2+]CC1)C(C)C,amide
199371,Please add a amide to the molecule CC(C)CC[C@](C)(O)CNC(=O)Cn1c(=O)[nH]c2ccccc2c1=O.,CC(C)CC[C@](C)(O)CNC(=O)Cn1c(=O)[nH]c2ccccc2c1=O,amide
69691,Please add a amine to the molecule C[C@H]1CCCC[C@@]1(NC(=O)N[C@@H]1CCOC1)C(=O)[O-].,C[C@H]1CCCC[C@@]1(NC(=O)N[C@@H]1CCOC1)C(=O)[O-],amine
196998,Add a carboxyl to the molecule Cc1ccc(NC(=O)c2ccc(NC(=O)c3ccco3)cc2)cc1[N+](=O)[O-].,Cc1ccc(NC(=O)c2ccc(NC(=O)c3ccco3)cc2)cc1[N+](=O)[O-],carboxyl
197237,Add a hydroxyl to the molecule CN(Cc1c(F)cccc1Cl)C(=O)c1ccc2c(c1)OCCO2.,CN(Cc1c(F)cccc1Cl)C(=O)c1ccc2c(c1)OCCO2,hydroxyl
153225,Add a benzene ring to the molecule Cc1ccc(C(C)C)c(O[C@H](C)C(=O)Nc2nnc(CC(C)C)s2)c1.,Cc1ccc(C(C)C)c(O[C@H](C)C(=O)Nc2nnc(CC(C)C)s2)c1,benzene ring
35035,Add a hydroxyl to the molecule CC[NH+](CC(=O)Nc1c(Cl)cc(N)cc1Cl)CC(C)C.,CC[NH+](CC(=O)Nc1c(Cl)cc(N)cc1Cl)CC(C)C,hydroxyl
245517,Add a hydroxyl to the molecule CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1.,CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1,hydroxyl
203728,Add a thiol to the molecule COc1c(C)cccc1C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C)C2.,COc1c(C)cccc1C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C)C2,thiol
20166,Please add a amine to the molecule C[C@H](CNC(=O)NCc1ccncc1)[NH+](C)C1CC1.,C[C@H](CNC(=O)NCc1ccncc1)[NH+](C)C1CC1,amine
25268,Modify the molecule CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1cccs1 by adding a halo.,CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1cccs1,halo
26243,Modify the molecule CCOC(=O)c1cc(Cl)c(NC(=O)c2cccc(OC)c2)cc1OC by adding a halo.,CCOC(=O)c1cc(Cl)c(NC(=O)c2cccc(OC)c2)cc1OC,halo
45529,Please add a nitro to the molecule O=C(Nc1nnc(C(F)(F)F)s1)c1ccc2[nH]cnc2c1.,O=C(Nc1nnc(C(F)(F)F)s1)c1ccc2[nH]cnc2c1,nitro
51071,Please add a amide to the molecule CCCC1CCC(NC(=O)C(=O)Nc2cnc3c(c2)c(C)nn3C)CC1.,CCCC1CCC(NC(=O)C(=O)Nc2cnc3c(c2)c(C)nn3C)CC1,amide
96744,Add a hydroxyl to the molecule O=S(=O)(NCCNc1cc(-n2cccc2)ncn1)c1ccc2cccc3c2c1CC3.,O=S(=O)(NCCNc1cc(-n2cccc2)ncn1)c1ccc2cccc3c2c1CC3,hydroxyl
173104,Please add a hydroxyl to the molecule Cc1nn(C)c(C)c1CC(=O)N(C)c1nc2ccccc2s1.,Cc1nn(C)c(C)c1CC(=O)N(C)c1nc2ccccc2s1,hydroxyl
18617,Add a amine to the molecule COc1cc(C[NH+]2CC[C@@H](Oc3cccnc3)C2)cc2c1OCCO2.,COc1cc(C[NH+]2CC[C@@H](Oc3cccnc3)C2)cc2c1OCCO2,amine
146373,Please add a hydroxyl to the molecule CC(=O)Nc1ccc(C(C)=O)cc1OCC(=O)Nc1ccc2c(c1)CCC2.,CC(=O)Nc1ccc(C(C)=O)cc1OCC(=O)Nc1ccc2c(c1)CCC2,hydroxyl
229098,Modify the molecule CCOC(=O)[C@H]1C[C@]2(C(=O)N(C)c3ccc(F)cc32)[NH+]2CCC[C@H]12 by adding a carboxyl.,CCOC(=O)[C@H]1C[C@]2(C(=O)N(C)c3ccc(F)cc32)[NH+]2CCC[C@H]12,carboxyl
240002,Modify the molecule Cc1ccc(C(=O)N2CCC[C@H](C(F)(F)F)C2)s1 by adding a amide.,Cc1ccc(C(=O)N2CCC[C@H](C(F)(F)F)C2)s1,amide
77701,Add a aldehyde to the molecule Cc1ncc([C@@H](C)N[C@H]2CCCN(S(C)(=O)=O)C2)s1.,Cc1ncc([C@@H](C)N[C@H]2CCCN(S(C)(=O)=O)C2)s1,aldehyde
44409,Please add a amine to the molecule CC(C)c1cc(C(=O)Nc2sc3c(c2C#N)CCCC3)on1.,CC(C)c1cc(C(=O)Nc2sc3c(c2C#N)CCCC3)on1,amine
13442,Add a hydroxyl to the molecule Cc1ccc2cccc(NC(=O)C(=O)N[C@@H](C)C[NH+]3CCC[C@H](C)C3)c2n1.,Cc1ccc2cccc(NC(=O)C(=O)N[C@@H](C)C[NH+]3CCC[C@H](C)C3)c2n1,hydroxyl
199247,Modify the molecule Cc1ccc([C@H](C)NC(=O)C[C@@H]2C=CCC2)cc1F by adding a hydroxyl.,Cc1ccc([C@H](C)NC(=O)C[C@@H]2C=CCC2)cc1F,hydroxyl
148972,Modify the molecule Cc1nccn1-c1ncccc1NC(=O)[C@@H]1COc2ccccc2C1 by adding a aldehyde.,Cc1nccn1-c1ncccc1NC(=O)[C@@H]1COc2ccccc2C1,aldehyde
82719,Please add a hydroxyl to the molecule COc1ncccc1CNC(=O)N[C@@H](c1ccccc1)c1cccc(F)c1.,COc1ncccc1CNC(=O)N[C@@H](c1ccccc1)c1cccc(F)c1,hydroxyl
100671,Add a nitro to the molecule C[C@H]1CN(C(=O)c2cc(Cl)cn2C)CC[C@H]1[NH3+].,C[C@H]1CN(C(=O)c2cc(Cl)cn2C)CC[C@H]1[NH3+],nitro
188346,Modify the molecule Cc1cccc(-c2ncc(-c3c(-c4ccccc4)ncn3CCC(N)=O)cn2)c1 by adding a benzene ring.,Cc1cccc(-c2ncc(-c3c(-c4ccccc4)ncn3CCC(N)=O)cn2)c1,benzene ring
59827,Add a amide to the molecule O=C(c1cc(-c2ccco2)on1)N1CCC(Oc2cccnc2)CC1.,O=C(c1cc(-c2ccco2)on1)N1CCC(Oc2cccnc2)CC1,amide
30809,Please add a hydroxyl to the molecule C[C@H](NC(=O)NCc1cccnc1)c1cccc(OC(F)F)c1.,C[C@H](NC(=O)NCc1cccnc1)c1cccc(OC(F)F)c1,hydroxyl
44248,Modify the molecule COC(=O)c1cc(F)cc(-c2ccc(C(=O)[O-])cc2C)c1 by adding a amine.,COC(=O)c1cc(F)cc(-c2ccc(C(=O)[O-])cc2C)c1,amine
109950,Modify the molecule CC(C)c1ncc(CNc2ccc(-c3nc(C4CC4)n[nH]3)cc2)s1 by adding a benzene ring.,CC(C)c1ncc(CNc2ccc(-c3nc(C4CC4)n[nH]3)cc2)s1,benzene ring
112910,Modify the molecule COC(CN(C)c1c[nH]c(=O)[nH]c1=O)OC by adding a nitro.,COC(CN(C)c1c[nH]c(=O)[nH]c1=O)OC,nitro
27604,Modify the molecule CC/[NH+]=C(/NCC#Cc1ccccc1)NC[C@@H](C)C#N by adding a hydroxyl.,CC/[NH+]=C(/NCC#Cc1ccccc1)NC[C@@H](C)C#N,hydroxyl
202189,Add a hydroxyl to the molecule Cc1cc(F)cc(/C([O-])=N/S(=O)(=O)c2ccccc2F)c1.,Cc1cc(F)cc(/C([O-])=N/S(=O)(=O)c2ccccc2F)c1,hydroxyl
29257,Modify the molecule COc1ccc([C@@H](O)C2(C#N)CCCCCC2)cc1Br by adding a benzene ring.,COc1ccc([C@@H](O)C2(C#N)CCCCCC2)cc1Br,benzene ring
174890,Add a amine to the molecule COC[C@H](C)[C@@](C)(O)C(=O)[O-].,COC[C@H](C)[C@@](C)(O)C(=O)[O-],amine
239777,Please add a amine to the molecule CN(C)C(=O)c1nnc(C(=O)[O-])s1.,CN(C)C(=O)c1nnc(C(=O)[O-])s1,amine
23163,Modify the molecule CCCNS(=O)(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1ccc(SC)cc1)N2 by adding a benzene ring.,CCCNS(=O)(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1ccc(SC)cc1)N2,benzene ring
150029,Please add a benzene ring to the molecule C[C@H]([NH3+])C[C@H](C)[C@@H]1CCc2cccnc21.,C[C@H]([NH3+])C[C@H](C)[C@@H]1CCc2cccnc21,benzene ring
112599,Please add a hydroxyl to the molecule O=C(CCCSc1ncnc2sccc12)c1ccc(Br)cc1.,O=C(CCCSc1ncnc2sccc12)c1ccc(Br)cc1,hydroxyl
221366,Modify the molecule CC[C@H](c1ccncc1)N(C)S(=O)(=O)c1ccc(C#N)cc1C by adding a thiol.,CC[C@H](c1ccncc1)N(C)S(=O)(=O)c1ccc(C#N)cc1C,thiol
205404,Add a benzene ring to the molecule C[NH+](C)CCN(Cc1ccco1)C(=O)c1cc(-c2cccs2)[nH]n1.,C[NH+](C)CCN(Cc1ccco1)C(=O)c1cc(-c2cccs2)[nH]n1,benzene ring
130741,Add a halo to the molecule COc1ccc(C(=O)NC(=S)Nc2cccc(Cl)c2)c(OC)c1.,COc1ccc(C(=O)NC(=S)Nc2cccc(Cl)c2)c(OC)c1,halo
30061,Modify the molecule CN1CCO[C@H](C(=O)N[C@@H](c2ccccc2)c2ccc3nc[nH]c3c2)C1 by adding a hydroxyl.,CN1CCO[C@H](C(=O)N[C@@H](c2ccccc2)c2ccc3nc[nH]c3c2)C1,hydroxyl
73990,Modify the molecule CCOc1ccc(N2C(=O)N=C([O-])/C(=C\c3ccccc3C)C2=O)cc1 by adding a benzene ring.,CCOc1ccc(N2C(=O)N=C([O-])/C(=C\c3ccccc3C)C2=O)cc1,benzene ring
168911,Modify the molecule COCc1ccc(C(=O)Nc2cc(F)ccc2F)cc1 by adding a hydroxyl.,COCc1ccc(C(=O)Nc2cc(F)ccc2F)cc1,hydroxyl
134013,Add a amide to the molecule COc1ccc(C[NH2+]Cc2cnn(C)c2C)cc1C[NH+]1CCCCC1.,COc1ccc(C[NH2+]Cc2cnn(C)c2C)cc1C[NH+]1CCCCC1,amide
214375,Modify the molecule Cc1ccc(C)c(OCC(=O)Nc2nc3c(s2)COCC3)c1 by adding a benzene ring.,Cc1ccc(C)c(OCC(=O)Nc2nc3c(s2)COCC3)c1,benzene ring
55526,Add a amide to the molecule CC(C)c1cccc(C(C)C)c1NC(=O)N1CCO[C@@H](c2ccccc2)C1.,CC(C)c1cccc(C(C)C)c1NC(=O)N1CCO[C@@H](c2ccccc2)C1,amide
40727,Please add a amide to the molecule O=S(=O)(c1ccccc1Br)N1CCN(c2nc3ccccc3s2)CC1.,O=S(=O)(c1ccccc1Br)N1CCN(c2nc3ccccc3s2)CC1,amide
110023,Please add a hydroxyl to the molecule CCNC(=O)c1ccccc1NC(=O)C1=NO[C@H](c2ccccc2)C1.,CCNC(=O)c1ccccc1NC(=O)C1=NO[C@H](c2ccccc2)C1,hydroxyl
22143,Please add a amide to the molecule N#Cc1ccc(N2CCN(C(=O)c3ccc4c(c3)OCCCO4)CC2)nc1.,N#Cc1ccc(N2CCN(C(=O)c3ccc4c(c3)OCCCO4)CC2)nc1,amide
239848,Please add a benzene ring to the molecule CCc1nn(C)c(OC)c1CNC(=O)c1cc(C)nc2cc(F)ccc12.,CCc1nn(C)c(OC)c1CNC(=O)c1cc(C)nc2cc(F)ccc12,benzene ring
103448,Please add a benzene ring to the molecule C#CCOc1cc(F)ccc1NC(=O)Nc1cc(CCC)nn1C.,C#CCOc1cc(F)ccc1NC(=O)Nc1cc(CCC)nn1C,benzene ring
247381,Modify the molecule CN(CC1CC[NH+](Cc2ccccc2)CC1)C(=O)[C@@H]1CC12CCC2 by adding a aldehyde.,CN(CC1CC[NH+](Cc2ccccc2)CC1)C(=O)[C@@H]1CC12CCC2,aldehyde
105879,Add a benzene ring to the molecule CCc1noc([C@@H](C)[NH+]2CCN(c3cccc(F)c3C#N)CC2)n1.,CCc1noc([C@@H](C)[NH+]2CCN(c3cccc(F)c3C#N)CC2)n1,benzene ring
191990,Please add a hydroxyl to the molecule CNC(=O)COc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1.,CNC(=O)COc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1,hydroxyl
151713,Modify the molecule O=C(Cc1ccc(F)cc1)n1nnc2ccccc21 by adding a thiol.,O=C(Cc1ccc(F)cc1)n1nnc2ccccc21,thiol
185484,Modify the molecule CCCNC(=O)c1cc(=O)[nH]c2c(C)cccc12 by adding a amide.,CCCNC(=O)c1cc(=O)[nH]c2c(C)cccc12,amide
194844,Modify the molecule CCCn1c([C@@H]2CC(=O)N(c3ccc4c(c3)OCO4)C2)nc2ccccc21 by adding a benzene ring.,CCCn1c([C@@H]2CC(=O)N(c3ccc4c(c3)OCO4)C2)nc2ccccc21,benzene ring
86347,Please add a benzene ring to the molecule C[C@H](NC(=O)CN1C(=O)[C@H]2CC=CC[C@@H]2C1=O)c1ccco1.,C[C@H](NC(=O)CN1C(=O)[C@H]2CC=CC[C@@H]2C1=O)c1ccco1,benzene ring
2335,Modify the molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 by adding a benzene ring.,Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1,benzene ring
51921,Please add a nitro to the molecule CC(C)c1cc(NC(=O)[C@H]2COc3ccc(Br)cc32)[nH]n1.,CC(C)c1cc(NC(=O)[C@H]2COc3ccc(Br)cc32)[nH]n1,nitro
50104,Please add a hydroxyl to the molecule CC(C)c1ccc(NC(=O)[C@@H]2Nc3ccccc3S(=O)(=O)N2)cc1.,CC(C)c1ccc(NC(=O)[C@@H]2Nc3ccccc3S(=O)(=O)N2)cc1,hydroxyl
66966,Add a amide to the molecule COCCN1C(=O)C([O-])=C(C(=O)c2c(C)nn(C)c2C)[C@@H]1c1cccs1.,COCCN1C(=O)C([O-])=C(C(=O)c2c(C)nn(C)c2C)[C@@H]1c1cccs1,amide
24235,Add a benzene ring to the molecule CCOc1ccccc1CNC(=O)N(C1CC1)[C@@H](C)C1CC1.,CCOc1ccccc1CNC(=O)N(C1CC1)[C@@H](C)C1CC1,benzene ring
148691,Add a carboxyl to the molecule CCN1C(=O)C(C)(C)COc2cc(NC(=O)c3cccn(C)c3=O)ccc21.,CCN1C(=O)C(C)(C)COc2cc(NC(=O)c3cccn(C)c3=O)ccc21,carboxyl
180962,Modify the molecule C[C@@H]1Cc2ccccc2N1C(=O)CSc1ccc(Cl)cc1 by adding a amide.,C[C@@H]1Cc2ccccc2N1C(=O)CSc1ccc(Cl)cc1,amide
38246,Please add a hydroxyl to the molecule O=S(=O)(c1ccc(F)cc1F)N1CC[C@@H](Nc2ccccc2)C1.,O=S(=O)(c1ccc(F)cc1F)N1CC[C@@H](Nc2ccccc2)C1,hydroxyl
39949,Please add a amide to the molecule C[C@@H]1CCCC[NH+]1CCC[NH2+]Cc1ccc(CO)o1.,C[C@@H]1CCCC[NH+]1CCC[NH2+]Cc1ccc(CO)o1,amide
38401,Add a halo to the molecule CCCOc1ccc(C(=O)N(Cc2ccc(F)cc2)c2ccccn2)cc1.,CCCOc1ccc(C(=O)N(Cc2ccc(F)cc2)c2ccccn2)cc1,halo
42508,Please add a amide to the molecule O=C(COc1ccc(I)cc1)NCCc1c[nH]c2ccccc12.,O=C(COc1ccc(I)cc1)NCCc1c[nH]c2ccccc12,amide
176153,Please add a benzene ring to the molecule O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1.,O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1,benzene ring
19694,Please add a benzene ring to the molecule Cc1nn(-c2ccc(F)cc2)c(C)c1C(=O)N1CCN(Cc2ccc3c(c2)OCO3)CC1.,Cc1nn(-c2ccc(F)cc2)c(C)c1C(=O)N1CCN(Cc2ccc3c(c2)OCO3)CC1,benzene ring
138329,Modify the molecule Cc1cc(C)c2nc(NC(=O)Cc3c(C)nc4nc(N)nn4c3C)sc2c1 by adding a carboxyl.,Cc1cc(C)c2nc(NC(=O)Cc3c(C)nc4nc(N)nn4c3C)sc2c1,carboxyl
130419,Modify the molecule O=C(Nc1cccc[n+]1Cc1ccccc1)c1cnc2ccc(F)cc2c1 by adding a hydroxyl.,O=C(Nc1cccc[n+]1Cc1ccccc1)c1cnc2ccc(F)cc2c1,hydroxyl
152772,Please add a hydroxyl to the molecule C#Cc1cccc(N(C)C(=O)C=C2CCSCC2)c1.,C#Cc1cccc(N(C)C(=O)C=C2CCSCC2)c1,hydroxyl
116813,Add a hydroxyl to the molecule C[C@H](CCc1cccn1C)NC(=O)COc1ccc(Br)cc1.,C[C@H](CCc1cccn1C)NC(=O)COc1ccc(Br)cc1,hydroxyl
172114,Add a benzene ring to the molecule O=C(N/N=C\c1ccc(Sc2ccccc2)o1)c1ccccc1.,O=C(N/N=C\c1ccc(Sc2ccccc2)o1)c1ccccc1,benzene ring
45957,Add a amide to the molecule C[C@H](C(=O)N1CCCCCC1)N1CC[NH+](C)CC1.,C[C@H](C(=O)N1CCCCCC1)N1CC[NH+](C)CC1,amide
21640,Add a amide to the molecule CC[C@@H](C)[C@@H](O)CSc1cccc(Br)c1.,CC[C@@H](C)[C@@H](O)CSc1cccc(Br)c1,amide
91073,Add a benzene ring to the molecule CN(C(=O)c1cc(-c2ccccc2)[nH]n1)C1(C#N)CCC1.,CN(C(=O)c1cc(-c2ccccc2)[nH]n1)C1(C#N)CCC1,benzene ring
214759,Please add a nitro to the molecule CC(C)[C@H]1CS(=O)(=O)CC[C@H](C)[NH2+]1.,CC(C)[C@H]1CS(=O)(=O)CC[C@H](C)[NH2+]1,nitro
209785,Add a aldehyde to the molecule Cc1ccc([C@@H]2C[S@](=O)C[C@H](C)N2)cc1F.,Cc1ccc([C@@H]2C[S@](=O)C[C@H](C)N2)cc1F,aldehyde
196718,Modify the molecule Cc1ccc(C)c(Oc2ccc(S(C)(=O)=O)cc2N)c1 by adding a benzene ring.,Cc1ccc(C)c(Oc2ccc(S(C)(=O)=O)cc2N)c1,benzene ring
52650,Please add a hydroxyl to the molecule CC[C@H]1Oc2ccc(S(=O)(=O)N3CCN(C(=O)c4ccc(C)c(F)c4)CC3)cc2NC1=O.,CC[C@H]1Oc2ccc(S(=O)(=O)N3CCN(C(=O)c4ccc(C)c(F)c4)CC3)cc2NC1=O,hydroxyl
227933,Please add a amine to the molecule C[C@@H](NC(=O)c1ccc2c(c1)CCN2S(C)(=O)=O)c1ccc(Cl)cc1Cl.,C[C@@H](NC(=O)c1ccc2c(c1)CCN2S(C)(=O)=O)c1ccc(Cl)cc1Cl,amine
183490,Please add a aldehyde to the molecule CCc1nc(-c2ccc(-n3cc(C(=O)Nc4ccc(Br)cc4F)c(C)n3)cc2)no1.,CCc1nc(-c2ccc(-n3cc(C(=O)Nc4ccc(Br)cc4F)c(C)n3)cc2)no1,aldehyde
109584,Add a hydroxyl to the molecule O=C([O-])C[NH+](C1CCCC1)[C@@H]1CCOC2(CCC2)C1.,O=C([O-])C[NH+](C1CCCC1)[C@@H]1CCOC2(CCC2)C1,hydroxyl
114233,Add a carboxyl to the molecule Cc1nnc(CN(C)C(=O)N[C@@H](C)C(C)C)n1C.,Cc1nnc(CN(C)C(=O)N[C@@H](C)C(C)C)n1C,carboxyl
201037,Please add a nitro to the molecule CCN1CCN(C(=O)CN2CCCC2=O)C[C@H](Cc2cccc(-c3ccccc3C)c2)C1=O.,CCN1CCN(C(=O)CN2CCCC2=O)C[C@H](Cc2cccc(-c3ccccc3C)c2)C1=O,nitro
46176,Modify the molecule C[C@H]1CN(Cc2nc(CCc3ccccc3)no2)[C@H](C)CO1 by adding a thiol.,C[C@H]1CN(Cc2nc(CCc3ccccc3)no2)[C@H](C)CO1,thiol
1911,Add a benzene ring to the molecule CCN(C(=O)C[NH2+]C1CCCCC1)c1ccccc1.,CCN(C(=O)C[NH2+]C1CCCCC1)c1ccccc1,benzene ring
210622,Add a hydroxyl to the molecule CCOc1ccc(O[C@@H](C)C(=O)NNC(=O)c2[nH]c3ccccc3c2Br)cc1.,CCOc1ccc(O[C@@H](C)C(=O)NNC(=O)c2[nH]c3ccccc3c2Br)cc1,hydroxyl
78016,Modify the molecule Cc1cc(OCC(C)(C)C(=O)[O-])cc(C(C)C)c1 by adding a amide.,Cc1cc(OCC(C)(C)C(=O)[O-])cc(C(C)C)c1,amide
76769,Please add a halo to the molecule CC(=O)c1ccc(OC(=O)Cc2csc(NC(=O)c3ccco3)n2)cc1.,CC(=O)c1ccc(OC(=O)Cc2csc(NC(=O)c3ccco3)n2)cc1,halo
138350,Please add a benzene ring to the molecule CCc1ncc(CN(C)[C@@H](C)Cc2cccs2)s1.,CCc1ncc(CN(C)[C@@H](C)Cc2cccs2)s1,benzene ring
222082,Please add a benzene ring to the molecule CC(C)CCSc1nnc2c(S(=O)(=O)N3CCOCC3)cccn12.,CC(C)CCSc1nnc2c(S(=O)(=O)N3CCOCC3)cccn12,benzene ring
217615,Please add a benzene ring to the molecule O=C1CC[C@H](C(=O)NNC(=O)COc2ccccc2-c2ccccc2)CN1.,O=C1CC[C@H](C(=O)NNC(=O)COc2ccccc2-c2ccccc2)CN1,benzene ring
147712,Modify the molecule Cn1c(NCc2ccc(C3=NN=CC3)cc2)c(C#N)c(=O)n(C)c1=O by adding a halo.,Cn1c(NCc2ccc(C3=NN=CC3)cc2)c(C#N)c(=O)n(C)c1=O,halo
76327,Add a aldehyde to the molecule CCCCN(C)C(=O)[C@@H]1CC(=O)N(c2cccc3ccccc23)C1.,CCCCN(C)C(=O)[C@@H]1CC(=O)N(c2cccc3ccccc23)C1,aldehyde
168192,Modify the molecule O=C(CN1CCO[C@H](c2cccc(F)c2)C1)NCc1cccc(Cl)c1 by adding a amide.,O=C(CN1CCO[C@H](c2cccc(F)c2)C1)NCc1cccc(Cl)c1,amide
84608,Modify the molecule COc1cccc(CN(C(=O)c2oc3ccc(C)cc3c2C)[C@H]2CCS(=O)(=O)C2)c1 by adding a hydroxyl.,COc1cccc(CN(C(=O)c2oc3ccc(C)cc3c2C)[C@H]2CCS(=O)(=O)C2)c1,hydroxyl
90299,Add a benzene ring to the molecule O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1.,O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1,benzene ring
159712,Please add a carboxyl to the molecule FC(F)(F)c1nc2ccccc2n1Cc1ccccc1.,FC(F)(F)c1nc2ccccc2n1Cc1ccccc1,carboxyl
146122,Modify the molecule C[NH2+]Cc1n[nH]c(=O)n1-c1ccc(C)cc1C by adding a hydroxyl.,C[NH2+]Cc1n[nH]c(=O)n1-c1ccc(C)cc1C,hydroxyl
36857,Please add a benzene ring to the molecule CC1(C)[C@@H](NC(=O)N[C@@H]2CC(=O)N(C(C)(C)C)C2)[C@@H]2CCO[C@@H]21.,CC1(C)[C@@H](NC(=O)N[C@@H]2CC(=O)N(C(C)(C)C)C2)[C@@H]2CCO[C@@H]21,benzene ring
130531,Please add a nitrile to the molecule CNC(=O)Cc1ccccc1NC(=O)NCc1ccccc1CO.,CNC(=O)Cc1ccccc1NC(=O)NCc1ccccc1CO,nitrile
178338,Modify the molecule N#Cc1csc(C(=O)NCc2nc(-c3cccs3)no2)c1 by adding a carboxyl.,N#Cc1csc(C(=O)NCc2nc(-c3cccs3)no2)c1,carboxyl
242560,Add a carboxyl to the molecule Cc1c(O[C@@H](C)C(=O)NCCc2c[nH]c3ccccc23)ccc2c3c(c(=O)oc12)CCC3.,Cc1c(O[C@@H](C)C(=O)NCCc2c[nH]c3ccccc23)ccc2c3c(c(=O)oc12)CCC3,carboxyl
19229,Please add a amide to the molecule COc1ccc(N2C[C@H](c3nc(-c4oc5ccc(OC)cc5c4C)no3)CC2=O)cc1.,COc1ccc(N2C[C@H](c3nc(-c4oc5ccc(OC)cc5c4C)no3)CC2=O)cc1,amide
203327,Modify the molecule CC1(C)CC[NH+](CC[NH2+]CCc2ccsc2)C1 by adding a hydroxyl.,CC1(C)CC[NH+](CC[NH2+]CCc2ccsc2)C1,hydroxyl
199375,Please add a amide to the molecule Cc1nonc1COc1ccccc1C(=O)[O-].,Cc1nonc1COc1ccccc1C(=O)[O-],amide
196733,Please add a benzene ring to the molecule O=C(Nc1ccc(C[NH+]2CCCCC2)cc1)Nc1ccc2c(c1)OCO2.,O=C(Nc1ccc(C[NH+]2CCCCC2)cc1)Nc1ccc2c(c1)OCO2,benzene ring
236169,Please add a halo to the molecule CCOC(=O)C1CCN(C(=O)C2CCN(c3ncnc4sc(C)c(C)c34)CC2)CC1.,CCOC(=O)C1CCN(C(=O)C2CCN(c3ncnc4sc(C)c(C)c34)CC2)CC1,halo
152431,Add a aldehyde to the molecule CN(CCOCC1CC1)c1nc2ccc(N)cc2s1.,CN(CCOCC1CC1)c1nc2ccc(N)cc2s1,aldehyde
161863,Add a benzene ring to the molecule COc1ccc(Oc2cc(N[C@@H](C)C(=O)N3CCCC3)ccc2OC)cc1.,COc1ccc(Oc2cc(N[C@@H](C)C(=O)N3CCCC3)ccc2OC)cc1,benzene ring
233846,Add a amide to the molecule Cc1cccc(C)c1CCNC(=O)c1cnc([C@H]2CCCO2)s1.,Cc1cccc(C)c1CCNC(=O)c1cnc([C@H]2CCCO2)s1,amide
111138,Please add a benzene ring to the molecule CCOc1ccc(/C=C2/C(=O)N(CCc3ccc(OC)cc3)C(=O)C(C#N)=C2C)cc1.,CCOc1ccc(/C=C2/C(=O)N(CCc3ccc(OC)cc3)C(=O)C(C#N)=C2C)cc1,benzene ring
61169,Add a amide to the molecule COC(=O)c1ccc(-c2ccc(/C=C3/C(=O)N=C(N)N3C)o2)cc1.,COC(=O)c1ccc(-c2ccc(/C=C3/C(=O)N=C(N)N3C)o2)cc1,amide
101998,Modify the molecule CC(C)(C)C(=O)Nc1ccc(C(=O)N2CCC[C@H](C(=O)NC3CCCCCC3)C2)cc1 by adding a benzene ring.,CC(C)(C)C(=O)Nc1ccc(C(=O)N2CCC[C@H](C(=O)NC3CCCCCC3)C2)cc1,benzene ring
156062,Add a halo to the molecule CC1=C(C(=O)OC(C)C)[C@@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1c1ccccc1.,CC1=C(C(=O)OC(C)C)[C@@H](c2cccc([N+](=O)[O-])c2)NC(=O)N1c1ccccc1,halo
104854,Add a aldehyde to the molecule NC(=O)c1ccc(OCC(=O)NC[C@@H](O)c2cccc(F)c2)cc1.,NC(=O)c1ccc(OCC(=O)NC[C@@H](O)c2cccc(F)c2)cc1,aldehyde
37166,Modify the molecule COc1ccccc1[C@@H]1[NH+]=N/C(=N\C(=O)c2ccco2)S1 by adding a hydroxyl.,COc1ccccc1[C@@H]1[NH+]=N/C(=N\C(=O)c2ccco2)S1,hydroxyl
132238,Modify the molecule Cc1nc(NCc2c[nH]nc2-c2ccccc2)sc1-c1ccn(C[C@@H]2COc3ccccc3O2)n1 by adding a benzene ring.,Cc1nc(NCc2c[nH]nc2-c2ccccc2)sc1-c1ccn(C[C@@H]2COc3ccccc3O2)n1,benzene ring
172445,Please add a amide to the molecule CCN(CC)c1ccc(CNC(=O)[C@H](C)N2C(=O)c3ccc(C)cc3C2=O)c[nH+]1.,CCN(CC)c1ccc(CNC(=O)[C@H](C)N2C(=O)c3ccc(C)cc3C2=O)c[nH+]1,amide
186411,Please add a amine to the molecule CCCCCCSc1nnc(-c2ccccc2N)c([O-])n1.,CCCCCCSc1nnc(-c2ccccc2N)c([O-])n1,amine
51102,Modify the molecule O=C(CN1C(=O)S/C(=C\c2ccccc2)C1=O)N1CCN(CCO)CC1 by adding a hydroxyl.,O=C(CN1C(=O)S/C(=C\c2ccccc2)C1=O)N1CCN(CCO)CC1,hydroxyl
149656,Please add a hydroxyl to the molecule CCCn1c(CCCCO)nc2cc(C#N)ccc21.,CCCn1c(CCCCO)nc2cc(C#N)ccc21,hydroxyl
76579,Add a hydroxyl to the molecule COCc1nc(C)cc(N2CCC[C@@H](CNC(=O)OC(C)(C)C)C2)n1.,COCc1nc(C)cc(N2CCC[C@@H](CNC(=O)OC(C)(C)C)C2)n1,hydroxyl
237828,Modify the molecule CS/C(=N\S(=O)(=O)c1ccc(C)cc1)N1CCN(S(=O)(=O)c2cc(C)ccc2C)CC1 by adding a amide.,CS/C(=N\S(=O)(=O)c1ccc(C)cc1)N1CCN(S(=O)(=O)c2cc(C)ccc2C)CC1,amide
131319,Modify the molecule N#Cc1ccc2nc(N3CCO[C@@H](c4cccc(O)c4)C3)ccc2c1 by adding a aldehyde.,N#Cc1ccc2nc(N3CCO[C@@H](c4cccc(O)c4)C3)ccc2c1,aldehyde
237443,Add a benzene ring to the molecule NC(=O)C1(NC(=O)c2nc(C3CC3)n3ccccc23)CC1.,NC(=O)C1(NC(=O)c2nc(C3CC3)n3ccccc23)CC1,benzene ring
22568,Please add a benzene ring to the molecule C[C@@H](Sc1nnc(C2CC2)n1C1CC1)C(=O)Nc1cccc2ccccc12.,C[C@@H](Sc1nnc(C2CC2)n1C1CC1)C(=O)Nc1cccc2ccccc12,benzene ring
231132,Please add a hydroxyl to the molecule O=C(Nc1ccc2c(c1)OCO2)N1CCC(Oc2nc3c(F)cccc3s2)CC1.,O=C(Nc1ccc2c(c1)OCO2)N1CCC(Oc2nc3c(F)cccc3s2)CC1,hydroxyl
188704,Add a nitro to the molecule C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1.,C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1,nitro
69669,Please add a amide to the molecule CCc1ccccc1NC(=O)CN1CCN(C(=O)NCc2ccc(N3CCCCCC3)[nH+]c2)CC1.,CCc1ccccc1NC(=O)CN1CCN(C(=O)NCc2ccc(N3CCCCCC3)[nH+]c2)CC1,amide
167421,Please add a amide to the molecule Cn1cnnc1[C@H]1CCCN1C(=O)c1c(O)cc(Cl)cc1Cl.,Cn1cnnc1[C@H]1CCCN1C(=O)c1c(O)cc(Cl)cc1Cl,amide
99525,Please add a benzene ring to the molecule C[NH+](Cc1ccccc1F)CC1(CS)CCC1.,C[NH+](Cc1ccccc1F)CC1(CS)CCC1,benzene ring
187952,Modify the molecule CN(C)c1ccc(C2=C(O)c3cccc4cccc(c34)C2=O)cc1 by adding a hydroxyl.,CN(C)c1ccc(C2=C(O)c3cccc4cccc(c34)C2=O)cc1,hydroxyl
9397,Please add a hydroxyl to the molecule O=C(Nc1nc(C(=O)Nc2cccc3ncccc23)co1)c1ccccc1.,O=C(Nc1nc(C(=O)Nc2cccc3ncccc23)co1)c1ccccc1,hydroxyl
16256,Please add a benzene ring to the molecule Cc1ccc(NC(=O)C2CCN(C(=O)c3ccco3)CC2)cc1S(=O)(=O)N1CCOCC1.,Cc1ccc(NC(=O)C2CCN(C(=O)c3ccco3)CC2)cc1S(=O)(=O)N1CCOCC1,benzene ring
164093,Add a carboxyl to the molecule Cc1nn([C@@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)N1CCN(S(C)(=O)=O)CC1.,Cc1nn([C@@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)N1CCN(S(C)(=O)=O)CC1,carboxyl
46796,Modify the molecule COc1cccc(OCCNC(=O)Nc2nnc(C)s2)c1 by adding a amide.,COc1cccc(OCCNC(=O)Nc2nnc(C)s2)c1,amide
96731,Please add a hydroxyl to the molecule COc1ccccc1[C@H](NC(=O)[C@H](C)NC(=O)c1ccoc1)C(C)(C)C.,COc1ccccc1[C@H](NC(=O)[C@H](C)NC(=O)c1ccoc1)C(C)(C)C,hydroxyl
135191,Add a hydroxyl to the molecule CC(C)[C@H](NC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccn1.,CC(C)[C@H](NC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccn1,hydroxyl
209046,Please add a hydroxyl to the molecule Cc1nn(-c2ccccc2)c(C)c1CN(C)C(=O)[C@@H]1CCO[C@@H]1C.,Cc1nn(-c2ccccc2)c(C)c1CN(C)C(=O)[C@@H]1CCO[C@@H]1C,hydroxyl
8923,Please add a carboxyl to the molecule O=C(Nc1ccc(F)c(Cl)c1)N1CCN(Cc2ccccc2)c2ncccc21.,O=C(Nc1ccc(F)c(Cl)c1)N1CCN(Cc2ccccc2)c2ncccc21,carboxyl
121765,Please add a aldehyde to the molecule COC(=O)[C@H](C)NC(=O)c1cc(Br)ccc1O.,COC(=O)[C@H](C)NC(=O)c1cc(Br)ccc1O,aldehyde
228639,Add a benzene ring to the molecule COC(=O)C1(C(=O)N2CCNC(=O)[C@@H]2c2ccc(F)cc2)CC1.,COC(=O)C1(C(=O)N2CCNC(=O)[C@@H]2c2ccc(F)cc2)CC1,benzene ring
100795,Modify the molecule Cc1ccc(C)c(N2CCN(C(=O)Cn3ncc4ccccc43)CC2)c1 by adding a nitrile.,Cc1ccc(C)c(N2CCN(C(=O)Cn3ncc4ccccc43)CC2)c1,nitrile
42611,Modify the molecule O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1 by adding a benzene ring.,O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1,benzene ring
246303,Modify the molecule COC[C@H](C)n1c(C)cc(C(=O)Cn2nnc(-c3ccccc3C)n2)c1C by adding a nitro.,COC[C@H](C)n1c(C)cc(C(=O)Cn2nnc(-c3ccccc3C)n2)c1C,nitro
121377,Add a hydroxyl to the molecule CC(C)C[C@@H]1CCCN1c1nc(C2CC2)ns1.,CC(C)C[C@@H]1CCCN1c1nc(C2CC2)ns1,hydroxyl
72016,Modify the molecule O=C(Nc1cccc(CN2CCCC2=O)c1)[C@H]1Cc2ccccc2O1 by adding a aldehyde.,O=C(Nc1cccc(CN2CCCC2=O)c1)[C@H]1Cc2ccccc2O1,aldehyde
44136,Add a benzene ring to the molecule COCCN1C(=O)CC[C@@H](C(=O)[O-])[C@H]1c1ccccc1C.,COCCN1C(=O)CC[C@@H](C(=O)[O-])[C@H]1c1ccccc1C,benzene ring
78008,Add a amine to the molecule C[C@H](Sc1nccn1C)C(=O)NC1CCCCCC1.,C[C@H](Sc1nccn1C)C(=O)NC1CCCCCC1,amine
118318,Modify the molecule c1ccc2c(c1)CC[C@@H]2NC1=[NH+]CCCCC1 by adding a amide.,c1ccc2c(c1)CC[C@@H]2NC1=[NH+]CCCCC1,amide
173331,Modify the molecule O=C(c1ccc(C[NH+]2CCC[C@H]3CCC[C@@H]32)cc1)N1CCCC1 by adding a hydroxyl.,O=C(c1ccc(C[NH+]2CCC[C@H]3CCC[C@@H]32)cc1)N1CCCC1,hydroxyl
168414,Please add a thiol to the molecule COC(=O)[C@@H](C)N1CCc2c(F)ccc(F)c2C1.,COC(=O)[C@@H](C)N1CCc2c(F)ccc(F)c2C1,thiol
218877,Add a amide to the molecule COc1ccc([C@H](NC(=O)C2C[C@@H](C)O[C@H](C)C2)c2nccn2C)cc1.,COc1ccc([C@H](NC(=O)C2C[C@@H](C)O[C@H](C)C2)c2nccn2C)cc1,amide
60306,Please add a amine to the molecule O=C(NCc1ccccn1)c1nn(CC2CC2)c2c1CN(C(=O)[C@H]1COc3ccccc3C1)CC2.,O=C(NCc1ccccn1)c1nn(CC2CC2)c2c1CN(C(=O)[C@H]1COc3ccccc3C1)CC2,amine
47182,Modify the molecule Cc1nc(C)c(C[NH+]2CCC[C@@H]2c2c(C)n[nH]c2C)s1 by adding a benzene ring.,Cc1nc(C)c(C[NH+]2CCC[C@@H]2c2c(C)n[nH]c2C)s1,benzene ring
220956,Add a benzene ring to the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)c1ccccc1N.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)c1ccccc1N,benzene ring
58368,Add a hydroxyl to the molecule CCCc1cc(=O)n2nc(-c3ccc(C)cc3)c(C)c2[nH]1.,CCCc1cc(=O)n2nc(-c3ccc(C)cc3)c(C)c2[nH]1,hydroxyl
40678,Modify the molecule COC(=O)C[C@H]1Cn2ncnc2NC1=O by adding a nitro.,COC(=O)C[C@H]1Cn2ncnc2NC1=O,nitro
248230,Add a benzene ring to the molecule CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1C[C@@H](C)O[C@H](C)C1.,CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1C[C@@H](C)O[C@H](C)C1,benzene ring
216798,Add a hydroxyl to the molecule CC(C)OC(=O)[C@@H](C)N(C)Cc1ccc(C(=O)N(C)C)[nH]1.,CC(C)OC(=O)[C@@H](C)N(C)Cc1ccc(C(=O)N(C)C)[nH]1,hydroxyl
41624,Please add a amide to the molecule CC[C@@H](NC(=O)COc1ccc(OC)cc1)c1ccccc1.,CC[C@@H](NC(=O)COc1ccc(OC)cc1)c1ccccc1,amide
17491,Please add a benzene ring to the molecule Cc1ncc(C[NH+](C)CCn2c(=O)oc3ccccc32)s1.,Cc1ncc(C[NH+](C)CCn2c(=O)oc3ccccc32)s1,benzene ring
5834,Please add a hydroxyl to the molecule N#C[C@H](Nc1cccc2ccccc12)c1ccccc1.,N#C[C@H](Nc1cccc2ccccc12)c1ccccc1,hydroxyl
47858,Please add a nitrile to the molecule CC(C)([C@@H](N)[C@H]1CCc2cccnc21)[NH+]1CCCCCC1.,CC(C)([C@@H](N)[C@H]1CCc2cccnc21)[NH+]1CCCCCC1,nitrile
29824,Please add a amide to the molecule CN(CCS(C)(=O)=O)C(=O)C[C@@H]1CCC[NH2+]C1.,CN(CCS(C)(=O)=O)C(=O)C[C@@H]1CCC[NH2+]C1,amide
115327,Please add a benzene ring to the molecule CCOCCC(=O)NCC(C)(C)C(N)=O.,CCOCCC(=O)NCC(C)(C)C(N)=O,benzene ring
13343,Add a halo to the molecule CC1(C)CC[C@@H](CN2CCOCC2)[C@@H]1O.,CC1(C)CC[C@@H](CN2CCOCC2)[C@@H]1O,halo
143903,Modify the molecule Cc1nc2ccccc2c(=O)n1CCOC(=O)C(C)C by adding a hydroxyl.,Cc1nc2ccccc2c(=O)n1CCOC(=O)C(C)C,hydroxyl
109729,Add a aldehyde to the molecule Cc1ccc([N+](=O)[O-])c(NCCCN2CCOCC2)c1.,Cc1ccc([N+](=O)[O-])c(NCCCN2CCOCC2)c1,aldehyde
115169,Please add a benzene ring to the molecule N=C1/C(=C/c2cccn2-c2ccc(Cl)c(Cl)c2)C(=O)N=C2SC(c3ccco3)=NN12.,N=C1/C(=C/c2cccn2-c2ccc(Cl)c(Cl)c2)C(=O)N=C2SC(c3ccco3)=NN12,benzene ring
35846,Add a aldehyde to the molecule Cc1c(Cl)nnc(NC[C@]2(C)CCCO2)c1C.,Cc1c(Cl)nnc(NC[C@]2(C)CCCO2)c1C,aldehyde
196581,Please add a amine to the molecule COc1ccc([N+](=O)[O-])cc1CN1CCN(c2ccccc2)CC1.,COc1ccc([N+](=O)[O-])cc1CN1CCN(c2ccccc2)CC1,amine
106573,Please add a carboxyl to the molecule O=S(=O)(N/N=C\c1cccc(OCc2ccc(F)cc2Cl)c1)c1ccc(F)cc1.,O=S(=O)(N/N=C\c1cccc(OCc2ccc(F)cc2Cl)c1)c1ccc(F)cc1,carboxyl
191952,Please add a hydroxyl to the molecule CCn1c(SCC(=O)N(C)[C@@H]2CCCC[C@@H]2C)nnc1C1CC1.,CCn1c(SCC(=O)N(C)[C@@H]2CCCC[C@@H]2C)nnc1C1CC1,hydroxyl
213321,Modify the molecule Cc1cc(C(=O)N2C[C@H](CO)OC[C@@H]2C)c(Cl)cc1F by adding a hydroxyl.,Cc1cc(C(=O)N2C[C@H](CO)OC[C@@H]2C)c(Cl)cc1F,hydroxyl
13961,Modify the molecule Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12 by adding a nitro.,Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12,nitro
246698,Add a amide to the molecule CC(C)Oc1ccc(C(=O)NN2CCOCC2)cn1.,CC(C)Oc1ccc(C(=O)NN2CCOCC2)cn1,amide
152710,Modify the molecule c1cc(-c2ccsc2)n2nc(SCc3ccc4c(c3)OCCCO4)nc2n1 by adding a hydroxyl.,c1cc(-c2ccsc2)n2nc(SCc3ccc4c(c3)OCCCO4)nc2n1,hydroxyl
25678,Please add a hydroxyl to the molecule CCOC(=O)c1c(NC(=O)c2cc(Cl)ccc2OC)sc2c1CCS(=O)(=O)C2.,CCOC(=O)c1c(NC(=O)c2cc(Cl)ccc2OC)sc2c1CCS(=O)(=O)C2,hydroxyl
232468,Please add a halo to the molecule CC(C)C[C@@H](C)[NH2+][C@H](C)CC(C)C.,CC(C)C[C@@H](C)[NH2+][C@H](C)CC(C)C,halo
60512,Add a amine to the molecule Nc1cc2[nH]c(=O)[nH]c2cc1Br.,Nc1cc2[nH]c(=O)[nH]c2cc1Br,amine
78092,Please add a benzene ring to the molecule CCc1cccc2c(C(=O)COc3ccc(-c4nnco4)cc3)c[nH]c12.,CCc1cccc2c(C(=O)COc3ccc(-c4nnco4)cc3)c[nH]c12,benzene ring
143980,Modify the molecule Cc1cc(OC(=O)[C@H](C)Cl)cc2c1C(=O)/C(=C/c1ccc(Cl)cc1)O2 by adding a benzene ring.,Cc1cc(OC(=O)[C@H](C)Cl)cc2c1C(=O)/C(=C/c1ccc(Cl)cc1)O2,benzene ring
80301,Please add a hydroxyl to the molecule Cc1nc(-c2ccccc2F)sc1[C@H](C)NCc1cccc(N(C)C)[nH+]1.,Cc1nc(-c2ccccc2F)sc1[C@H](C)NCc1cccc(N(C)C)[nH+]1,hydroxyl
205317,Please add a carboxyl to the molecule O=C(Nc1cccc(OC[C@H]2CCCO2)c1)[C@@H]1CCCN(c2cnccn2)C1.,O=C(Nc1cccc(OC[C@H]2CCCO2)c1)[C@@H]1CCCN(c2cnccn2)C1,carboxyl
93016,Modify the molecule Cc1cccc(C(=O)N2C[C@@H](C)OCC2(C)C)c1F by adding a aldehyde.,Cc1cccc(C(=O)N2C[C@@H](C)OCC2(C)C)c1F,aldehyde
116532,Please add a hydroxyl to the molecule NC(=O)c1ccc(NC(=O)N2CCC(c3ccc(F)cc3)CC2)cc1.,NC(=O)c1ccc(NC(=O)N2CCC(c3ccc(F)cc3)CC2)cc1,hydroxyl
184274,Add a benzene ring to the molecule CO[C@H](CNC(=O)Cn1ccc(=O)[nH]c1=O)c1cccc(Cl)c1.,CO[C@H](CNC(=O)Cn1ccc(=O)[nH]c1=O)c1cccc(Cl)c1,benzene ring
213967,Add a hydroxyl to the molecule Cc1cccc(NC(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)CCCC(=O)N4)CC2)c1C.,Cc1cccc(NC(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)CCCC(=O)N4)CC2)c1C,hydroxyl
60018,Please add a amide to the molecule C/C(=N\c1ncccc1C)c1c(-c2ccccc2)nn(-c2ccc(F)cc2)c1O.,C/C(=N\c1ncccc1C)c1c(-c2ccccc2)nn(-c2ccc(F)cc2)c1O,amide
109073,Modify the molecule Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)Cc2cccc(Cl)c2)c1 by adding a benzene ring.,Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)Cc2cccc(Cl)c2)c1,benzene ring
234037,Add a benzene ring to the molecule Cc1ccccc1-c1nnc2n1N=C(c1ccc([N+](=O)[O-])cc1)CS2.,Cc1ccccc1-c1nnc2n1N=C(c1ccc([N+](=O)[O-])cc1)CS2,benzene ring
182373,Modify the molecule C[C@H]1CCCC[C@]12NC(=O)N(CC(=O)Nc1nc3ccc(Cl)cc3s1)C2=O by adding a hydroxyl.,C[C@H]1CCCC[C@]12NC(=O)N(CC(=O)Nc1nc3ccc(Cl)cc3s1)C2=O,hydroxyl
72965,Please add a hydroxyl to the molecule Cc1cccc(OCCN(C)C(=O)NCCC(=O)N(C)C)c1.,Cc1cccc(OCCN(C)C(=O)NCCC(=O)N(C)C)c1,hydroxyl
72865,Modify the molecule CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1 by adding a amide.,CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1,amide
64466,Please add a amine to the molecule CC(C)NS(=O)(=O)c1ccsc1CO.,CC(C)NS(=O)(=O)c1ccsc1CO,amine
233548,Modify the molecule C[C@@H](CNc1c(C#N)c(=O)n(C)c(=O)n1C)N1CC[NH+](C)CC1 by adding a benzene ring.,C[C@@H](CNc1c(C#N)c(=O)n(C)c(=O)n1C)N1CC[NH+](C)CC1,benzene ring
77107,Add a nitro to the molecule CC[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C.,CC[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C,nitro
36580,Please add a amine to the molecule COc1ccc(OC)c(N2C[C@@](O)(c3ccc(Br)cc3)[N+]3=C2CCCCC3)c1.,COc1ccc(OC)c(N2C[C@@](O)(c3ccc(Br)cc3)[N+]3=C2CCCCC3)c1,amine
157090,Please add a benzene ring to the molecule CC(C)c1c([O-])[nH]c(-c2ccc(Cl)cn2)nc1=O.,CC(C)c1c([O-])[nH]c(-c2ccc(Cl)cn2)nc1=O,benzene ring
150109,Please add a amine to the molecule CC(C)(C)[NH2+]CC[C@@](C)(O)[C@H]1CCOC2(CCC2)C1.,CC(C)(C)[NH2+]CC[C@@](C)(O)[C@H]1CCOC2(CCC2)C1,amine
150622,Please add a benzene ring to the molecule Cc1csc(SCc2cc(=O)oc3cc(C)c(C)cc23)n1.,Cc1csc(SCc2cc(=O)oc3cc(C)c(C)cc23)n1,benzene ring
1520,Please add a nitro to the molecule CC(C)C[C@H]1COCCN1C(=O)CSCC(=O)c1ccccc1.,CC(C)C[C@H]1COCCN1C(=O)CSCC(=O)c1ccccc1,nitro
217853,Modify the molecule COC(=O)c1ccccc1-c1ccc(/C=C(\C#N)C(=O)[O-])o1 by adding a benzene ring.,COC(=O)c1ccccc1-c1ccc(/C=C(\C#N)C(=O)[O-])o1,benzene ring
139386,Add a hydroxyl to the molecule Cc1cccc2[nH+]c(CNC(=O)c3ccc4cc[nH]c4c3)cn12.,Cc1cccc2[nH+]c(CNC(=O)c3ccc4cc[nH]c4c3)cn12,hydroxyl
200458,Please add a halo to the molecule CCOc1cccc2c1O[C@]1(C)C[C@H]2NC(=S)N1c1ccc(F)cc1.,CCOc1cccc2c1O[C@]1(C)C[C@H]2NC(=S)N1c1ccc(F)cc1,halo
6436,Modify the molecule CCC[C@@]1(C(=O)[O-])CCN(C(=O)[C@@H]2CC[NH2+][C@@H]2C)C1 by adding a carboxyl.,CCC[C@@]1(C(=O)[O-])CCN(C(=O)[C@@H]2CC[NH2+][C@@H]2C)C1,carboxyl
169882,Please add a halo to the molecule O=CN1CCC[C@H]1[C@@H]1CCCC1=O.,O=CN1CCC[C@H]1[C@@H]1CCCC1=O,halo
35697,Please add a benzene ring to the molecule COCC[NH+](C[C@@H]1CCC[NH+](C2Cc3ccccc3C2)C1)C1CCC1.,COCC[NH+](C[C@@H]1CCC[NH+](C2Cc3ccccc3C2)C1)C1CCC1,benzene ring
57960,Add a benzene ring to the molecule COc1ccc(SCCC(=O)NC2=NCCS2)cc1.,COc1ccc(SCCC(=O)NC2=NCCS2)cc1,benzene ring
38263,Please add a hydroxyl to the molecule Cc1nnc(C[NH+](C)C2CCC(c3ccc(O)cc3)CC2)n1C.,Cc1nnc(C[NH+](C)C2CCC(c3ccc(O)cc3)CC2)n1C,hydroxyl
224309,Modify the molecule Cc1ccc2oc(-c3ccc(C)c(NC(=S)NC(=O)c4ccc([N+](=O)[O-])cc4)c3)nc2c1 by adding a benzene ring.,Cc1ccc2oc(-c3ccc(C)c(NC(=S)NC(=O)c4ccc([N+](=O)[O-])cc4)c3)nc2c1,benzene ring
69058,Modify the molecule CCc1cc(C(=O)N(C)Cc2cccc3ncccc23)cs1 by adding a benzene ring.,CCc1cc(C(=O)N(C)Cc2cccc3ncccc23)cs1,benzene ring
221157,Add a benzene ring to the molecule Cc1nn(C)c2c1nc([C@H](C)Cl)n2CC(C)(C)S(C)(=O)=O.,Cc1nn(C)c2c1nc([C@H](C)Cl)n2CC(C)(C)S(C)(=O)=O,benzene ring
11977,Add a hydroxyl to the molecule CC[C@](C)([C@@H](O)c1ccc(F)c(C)c1)N1CCOCC1.,CC[C@](C)([C@@H](O)c1ccc(F)c(C)c1)N1CCOCC1,hydroxyl
25757,Please add a hydroxyl to the molecule O=c1[nH]c2c(c(=O)n1-c1ccccc1)CCCS2.,O=c1[nH]c2c(c(=O)n1-c1ccccc1)CCCS2,hydroxyl
131189,Modify the molecule Cc1ccc(-c2nnn(CC(=O)N(c3cnc4ccccc4c3)[C@H](C)C(=O)NC3CCCC3)n2)cc1 by adding a hydroxyl.,Cc1ccc(-c2nnn(CC(=O)N(c3cnc4ccccc4c3)[C@H](C)C(=O)NC3CCCC3)n2)cc1,hydroxyl
221010,Please add a benzene ring to the molecule O=S(=O)(Cc1ccccc1Cl)NCc1ccoc1.,O=S(=O)(Cc1ccccc1Cl)NCc1ccoc1,benzene ring
134547,Modify the molecule C[C@@H]([NH2+]Cc1ccc(N(C)CCC#N)cc1)c1ccc2c(c1)OCO2 by adding a halo.,C[C@@H]([NH2+]Cc1ccc(N(C)CCC#N)cc1)c1ccc2c(c1)OCO2,halo
32543,Please add a hydroxyl to the molecule COc1ccccc1C(=O)Nc1ccnn1C1CC[NH+](Cc2cc(C)c(C)o2)CC1.,COc1ccccc1C(=O)Nc1ccnn1C1CC[NH+](Cc2cc(C)c(C)o2)CC1,hydroxyl
65527,Add a benzene ring to the molecule COC[C@H](O)CC[NH2+][C@H](C)c1c[nH]c2cc(Cl)ccc12.,COC[C@H](O)CC[NH2+][C@H](C)c1c[nH]c2cc(Cl)ccc12,benzene ring
221581,Add a amide to the molecule Nn1c(SCc2ccccn2)nnc1C1CCOCC1.,Nn1c(SCc2ccccn2)nnc1C1CCOCC1,amide
151435,Modify the molecule COC(=O)c1cccc(CN2C(=O)N[C@@]3(CCCc4ccccc43)C2=O)c1 by adding a hydroxyl.,COC(=O)c1cccc(CN2C(=O)N[C@@]3(CCCc4ccccc43)C2=O)c1,hydroxyl
80221,Modify the molecule Cc1cc([N-]S(=O)(=O)c2cccc(N)c2C)ccn1 by adding a nitro.,Cc1cc([N-]S(=O)(=O)c2cccc(N)c2C)ccn1,nitro
217646,Modify the molecule Cc1ccccc1NC(=O)NCC1(CN2CCOCC2)CCCCC1 by adding a benzene ring.,Cc1ccccc1NC(=O)NCC1(CN2CCOCC2)CCCCC1,benzene ring
131254,Modify the molecule Cc1ccc(NCCNC(=O)c2ccc3c(c2)COCO3)n[nH+]1 by adding a hydroxyl.,Cc1ccc(NCCNC(=O)c2ccc3c(c2)COCO3)n[nH+]1,hydroxyl
189957,Add a benzene ring to the molecule CCC(CC)C[NH+]1C[C@@H]([NH3+])C[C@@H](C)C1.,CCC(CC)C[NH+]1C[C@@H]([NH3+])C[C@@H](C)C1,benzene ring
41670,Add a hydroxyl to the molecule COc1cccc(CN2C(=O)C([O-])=C(S(=O)(=O)c3ccc(Cl)cc3)[C@@H]2c2ccccc2)c1.,COc1cccc(CN2C(=O)C([O-])=C(S(=O)(=O)c3ccc(Cl)cc3)[C@@H]2c2ccccc2)c1,hydroxyl
110045,Modify the molecule O=C1CCc2c1cnn2-c1ccccc1 by adding a amine.,O=C1CCc2c1cnn2-c1ccccc1,amine
76056,Modify the molecule Cc1c(C(=O)N[C@H](C[NH+](C)C)c2ccccc2)cnn1-c1ccccc1 by adding a amine.,Cc1c(C(=O)N[C@H](C[NH+](C)C)c2ccccc2)cnn1-c1ccccc1,amine
24728,Modify the molecule CC(C)(C)[C@@H](NC(=O)c1cc([N-]S(C)(=O)=O)ccc1O)c1cccs1 by adding a aldehyde.,CC(C)(C)[C@@H](NC(=O)c1cc([N-]S(C)(=O)=O)ccc1O)c1cccs1,aldehyde
171490,Add a hydroxyl to the molecule O=C([O-])c1ccccc1C(=O)c1cccc(S(=O)(=O)N2CCOCC2)c1.,O=C([O-])c1ccccc1C(=O)c1cccc(S(=O)(=O)N2CCOCC2)c1,hydroxyl
30819,Modify the molecule CCC[NH2+][C@H]1[C@H](CN2CCCOCC2)CCC1(C)C by adding a aldehyde.,CCC[NH2+][C@H]1[C@H](CN2CCCOCC2)CCC1(C)C,aldehyde
164799,Please add a hydroxyl to the molecule COc1ccccc1/C=C/C[NH+]1CCC2(CC1)C[C@H]2C(=O)N(C)Cc1cscn1.,COc1ccccc1/C=C/C[NH+]1CCC2(CC1)C[C@H]2C(=O)N(C)Cc1cscn1,hydroxyl
122900,Please add a hydroxyl to the molecule CC(=O)c1ccc(NS(=O)(=O)c2ccccc2C#N)cc1.,CC(=O)c1ccc(NS(=O)(=O)c2ccccc2C#N)cc1,hydroxyl
46285,Modify the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4c(C)nn(-c5ccccn5)c4C)CC3)CC2=O)cc1 by adding a benzene ring.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4c(C)nn(-c5ccccn5)c4C)CC3)CC2=O)cc1,benzene ring
154904,Modify the molecule CCCC(CCC)C(=O)Nc1nccs1 by adding a benzene ring.,CCCC(CCC)C(=O)Nc1nccs1,benzene ring
57673,Add a carboxyl to the molecule O=C(c1ccc(S(=O)(=O)N2CCCCC2)cc1)N(c1ccccc1)[C@@H]1C=CS(=O)(=O)C1.,O=C(c1ccc(S(=O)(=O)N2CCCCC2)cc1)N(c1ccccc1)[C@@H]1C=CS(=O)(=O)C1,carboxyl
235247,Please add a thiol to the molecule Fc1cc([C@H]2OCC[C@@H]2Nc2ncnc3[nH]cnc23)ccc1Cl.,Fc1cc([C@H]2OCC[C@@H]2Nc2ncnc3[nH]cnc23)ccc1Cl,thiol
146729,Add a benzene ring to the molecule CN(C)S(=O)(=O)c1cccc(NC(=O)COc2ccc(Br)cc2)c1.,CN(C)S(=O)(=O)c1cccc(NC(=O)COc2ccc(Br)cc2)c1,benzene ring
247155,Add a hydroxyl to the molecule O=[N+]([O-])c1cc(F)ccc1OC[C@H]1Cc2ccccc2S1.,O=[N+]([O-])c1cc(F)ccc1OC[C@H]1Cc2ccccc2S1,hydroxyl
187934,Add a amine to the molecule CS(=O)(=O)CCn1cnc2ccc(Br)cc2c1=O.,CS(=O)(=O)CCn1cnc2ccc(Br)cc2c1=O,amine
38800,Please add a benzene ring to the molecule CCO[C@@H]1C[C@H](NC(=O)N(C)C2CCS(=O)CC2)C12CCC2.,CCO[C@@H]1C[C@H](NC(=O)N(C)C2CCS(=O)CC2)C12CCC2,benzene ring
209826,Modify the molecule COc1ccc(CC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1 by adding a carboxyl.,COc1ccc(CC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1,carboxyl
219741,Please add a hydroxyl to the molecule Cc1cc(N)cc(S(=O)(=O)Nc2ccccc2C(C)C)c1.,Cc1cc(N)cc(S(=O)(=O)Nc2ccccc2C(C)C)c1,hydroxyl
44353,Add a benzene ring to the molecule C[C@@H](Oc1ccccc1)c1nnc(SCC(=O)N2CCc3ccccc32)n1-c1ccccc1.,C[C@@H](Oc1ccccc1)c1nnc(SCC(=O)N2CCc3ccccc32)n1-c1ccccc1,benzene ring
191376,Add a hydroxyl to the molecule Cc1nnc(NCCOc2cccc(Br)c2)c(C#N)c1C.,Cc1nnc(NCCOc2cccc(Br)c2)c(C#N)c1C,hydroxyl
137914,Add a amide to the molecule O=C(C[C@@H]1CCCO1)Nc1ccc(Br)cc1C(F)(F)F.,O=C(C[C@@H]1CCCO1)Nc1ccc(Br)cc1C(F)(F)F,amide
225911,Add a benzene ring to the molecule CC(C)=CC(=O)N1CCN2NC([C@@H]3[NH+]=c4ccc(Cl)cc4=[NH+]3)=C[C@@H]2C1.,CC(C)=CC(=O)N1CCN2NC([C@@H]3[NH+]=c4ccc(Cl)cc4=[NH+]3)=C[C@@H]2C1,benzene ring
228855,Add a hydroxyl to the molecule c1ccc(CCCOC2C[NH2+]C2)cc1.,c1ccc(CCCOC2C[NH2+]C2)cc1,hydroxyl
170006,Add a carboxyl to the molecule C[C@H]1CCc2cc(F)ccc2N1C(=O)Nc1cccc(F)c1.,C[C@H]1CCc2cc(F)ccc2N1C(=O)Nc1cccc(F)c1,carboxyl
144869,Modify the molecule CCc1nc(CNc2cccc(C(=O)N3CCSCC3)c2C)no1 by adding a halo.,CCc1nc(CNc2cccc(C(=O)N3CCSCC3)c2C)no1,halo
56903,Please add a carboxyl to the molecule C[C@@H]1Cc2cc(C(=O)C3=C([O-])C(=O)N(C[C@@H]4CCCO4)[C@H]3c3cccc([N+](=O)[O-])c3)ccc2O1.,C[C@@H]1Cc2cc(C(=O)C3=C([O-])C(=O)N(C[C@@H]4CCCO4)[C@H]3c3cccc([N+](=O)[O-])c3)ccc2O1,carboxyl
51629,Please add a aldehyde to the molecule C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1.,C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1,aldehyde
158569,Add a benzene ring to the molecule COCCNC(=O)Nc1ccc(C(=O)N2CCCCC2)c(Cl)c1.,COCCNC(=O)Nc1ccc(C(=O)N2CCCCC2)c(Cl)c1,benzene ring
51960,Add a benzene ring to the molecule O=C(NCCC1=c2ccccc2=[NH+]C1)[C@@H](Cc1ccccc1)NC(=O)N1CC(O)=Nc2ccccc21.,O=C(NCCC1=c2ccccc2=[NH+]C1)[C@@H](Cc1ccccc1)NC(=O)N1CC(O)=Nc2ccccc21,benzene ring
46480,Modify the molecule NC(=O)[C@H]1COCCN1CC(=O)Nc1ccc(F)c(Cl)c1 by adding a aldehyde.,NC(=O)[C@H]1COCCN1CC(=O)Nc1ccc(F)c(Cl)c1,aldehyde
53527,Please add a halo to the molecule [NH3+]CCC1=c2cc([N+](=O)[O-])ccc2=[NH+][C@H]1C(=O)[O-].,[NH3+]CCC1=c2cc([N+](=O)[O-])ccc2=[NH+][C@H]1C(=O)[O-],halo
130867,Modify the molecule O=S(=O)(NC[C@@H](c1ccco1)N1CCOCC1)c1ccc(Cl)cc1 by adding a amine.,O=S(=O)(NC[C@@H](c1ccco1)N1CCOCC1)c1ccc(Cl)cc1,amine
121220,Modify the molecule Cc1ccc(-c2ccc(N)cc2)c(C)c1 by adding a amide.,Cc1ccc(-c2ccc(N)cc2)c(C)c1,amide
134108,Please add a benzene ring to the molecule CC(=O)N1CCc2cc(CNC(=O)Cc3ccc(F)cc3)ccc21.,CC(=O)N1CCc2cc(CNC(=O)Cc3ccc(F)cc3)ccc21,benzene ring
116911,Please add a carboxyl to the molecule Cc1ccc(NC(=O)N(C)CCC#N)c(OCC(F)(F)F)c1.,Cc1ccc(NC(=O)N(C)CCC#N)c(OCC(F)(F)F)c1,carboxyl
10323,Add a amine to the molecule CN(Cc1cccc(F)c1)c1ccc(CO)cc1.,CN(Cc1cccc(F)c1)c1ccc(CO)cc1,amine
165063,Please add a nitro to the molecule O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1.,O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1,nitro
56383,Add a hydroxyl to the molecule O=C([O-])c1cc(Br)ccc1OCc1ccccc1F.,O=C([O-])c1cc(Br)ccc1OCc1ccccc1F,hydroxyl
175402,Please add a hydroxyl to the molecule O=C1CC[C@@H](NC(=O)C/C=C/c2ccc(F)cc2)CN1.,O=C1CC[C@@H](NC(=O)C/C=C/c2ccc(F)cc2)CN1,hydroxyl
71072,Modify the molecule CCN(CC)S(=O)(=O)c1ccc([C@@H](C)NC(=O)c2ccc(C)c(C)c2)cc1 by adding a hydroxyl.,CCN(CC)S(=O)(=O)c1ccc([C@@H](C)NC(=O)c2ccc(C)c(C)c2)cc1,hydroxyl
162138,Please add a benzene ring to the molecule CCO[C@@H]1C[C@@H]([O-])C12CC[NH+](Cc1cc(C)c(C)cc1C)CC2.,CCO[C@@H]1C[C@@H]([O-])C12CC[NH+](Cc1cc(C)c(C)cc1C)CC2,benzene ring
81888,Modify the molecule CC[C@H](C)[C@@H](C)[NH2+][C@@H](CCC#N)c1ccccc1 by adding a amide.,CC[C@H](C)[C@@H](C)[NH2+][C@@H](CCC#N)c1ccccc1,amide
90212,Modify the molecule CC(C)CCNC(=O)NCCC(=O)NC1CCCC1 by adding a amine.,CC(C)CCNC(=O)NCCC(=O)NC1CCCC1,amine
34957,Please add a amide to the molecule CCN1CCN[C@@H](Cc2ccc(-c3cccc(OC)c3)cc2)C1=O.,CCN1CCN[C@@H](Cc2ccc(-c3cccc(OC)c3)cc2)C1=O,amide
131119,Add a amide to the molecule C[C@H](NC(=O)C1CCN(c2ccccc2[N+](=O)[O-])CC1)C(N)=O.,C[C@H](NC(=O)C1CCN(c2ccccc2[N+](=O)[O-])CC1)C(N)=O,amide
225831,Add a amide to the molecule CCCCNC(=O)c1cccn1-c1nnc(N2CCCCC2)s1.,CCCCNC(=O)c1cccn1-c1nnc(N2CCCCC2)s1,amide
124374,Please add a amine to the molecule CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1.,CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1,amine
203161,Please add a amide to the molecule CCCNC(=O)[C@@H](C)[NH2+]C[C@@H](O)c1ccc(F)cc1F.,CCCNC(=O)[C@@H](C)[NH2+]C[C@@H](O)c1ccc(F)cc1F,amide
83925,Add a hydroxyl to the molecule C=CCC/C=C/CC[NH2+]C1CC1.,C=CCC/C=C/CC[NH2+]C1CC1,hydroxyl
240960,Please add a amide to the molecule COc1ccc(NC(=O)C(=O)NCC(N)=S)cc1OC.,COc1ccc(NC(=O)C(=O)NCC(N)=S)cc1OC,amide
94035,Please add a benzene ring to the molecule CC(C)Oc1ccc(C(=O)/C=C/c2cccnc2)cc1.,CC(C)Oc1ccc(C(=O)/C=C/c2cccnc2)cc1,benzene ring
179566,Add a halo to the molecule CC1(C)CCC[C@@]2(O[C@H]2c2ccc(Cl)cc2)C1=O.,CC1(C)CCC[C@@]2(O[C@H]2c2ccc(Cl)cc2)C1=O,halo
112012,Add a hydroxyl to the molecule CCc1ccc(CNC(=O)[C@@H]2c3ccccc3C(=O)N3CCc4cc(OC)c(OC)cc4[C@H]23)cc1.,CCc1ccc(CNC(=O)[C@@H]2c3ccccc3C(=O)N3CCc4cc(OC)c(OC)cc4[C@H]23)cc1,hydroxyl
20976,Add a benzene ring to the molecule CC(C)N(C)C(=O)C1CC[NH+](CC(=O)N2CC(=O)Nc3ccccc32)CC1.,CC(C)N(C)C(=O)C1CC[NH+](CC(=O)N2CC(=O)Nc3ccccc32)CC1,benzene ring
143651,Add a hydroxyl to the molecule CCOC(=O)[C@H]1CCCN(C(=O)[C@@H](C(=O)c2ccccc2)n2ccccc2=O)C1.,CCOC(=O)[C@H]1CCCN(C(=O)[C@@H](C(=O)c2ccccc2)n2ccccc2=O)C1,hydroxyl
29631,Add a benzene ring to the molecule C[C@@H](C1CC1)N(C(=O)[C@H]1CCCN(C(=O)COc2ccccc2)C1)C1CC1.,C[C@@H](C1CC1)N(C(=O)[C@H]1CCCN(C(=O)COc2ccccc2)C1)C1CC1,benzene ring
71997,Modify the molecule CCN(C(=O)c1cc(-c2cnc(C(C)C)nc2)nc2cc(C)ccc12)C(C)C by adding a benzene ring.,CCN(C(=O)c1cc(-c2cnc(C(C)C)nc2)nc2cc(C)ccc12)C(C)C,benzene ring
82412,Add a benzene ring to the molecule CC(C)=CC(=O)NCc1ccc(C(=O)NCCc2ccc(C)nc2)cc1.,CC(C)=CC(=O)NCc1ccc(C(=O)NCCc2ccc(C)nc2)cc1,benzene ring
12831,Modify the molecule [NH3+][C@@H]1C=C[C@@H](C(=O)NCCc2cccs2)C1 by adding a benzene ring.,[NH3+][C@@H]1C=C[C@@H](C(=O)NCCc2cccs2)C1,benzene ring
48933,Please add a nitrile to the molecule CN(CCS(C)(=O)=O)c1ncc(C[NH2+]C(C)(C)C)s1.,CN(CCS(C)(=O)=O)c1ncc(C[NH2+]C(C)(C)C)s1,nitrile
83605,Please add a amide to the molecule CCCN1C(=O)c2[nH]nc(-c3ccco3)c2[C@@H]1c1ccccc1OC.,CCCN1C(=O)c2[nH]nc(-c3ccco3)c2[C@@H]1c1ccccc1OC,amide
105364,Add a nitro to the molecule Cc1ccc(C(=O)C2=NN(c3ccccc3)[C@H]3C(=O)N(c4cccc([N+](=O)[O-])c4)C(=O)[C@H]23)cc1.,Cc1ccc(C(=O)C2=NN(c3ccccc3)[C@H]3C(=O)N(c4cccc([N+](=O)[O-])c4)C(=O)[C@H]23)cc1,nitro
83423,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F)[C@@H]1C by adding a amide.,C[C@H]1CCC[C@@H](NC(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F)[C@@H]1C,amide
62585,Modify the molecule COCCN1CC(=O)N(c2ccc([N+](=O)[O-])cc2)C1=O by adding a hydroxyl.,COCCN1CC(=O)N(c2ccc([N+](=O)[O-])cc2)C1=O,hydroxyl
71130,Add a benzene ring to the molecule C[NH2+][C@H](Cc1nc(C)cs1)c1cc(C)ccn1.,C[NH2+][C@H](Cc1nc(C)cs1)c1cc(C)ccn1,benzene ring
147790,Modify the molecule CC[C@](C)([NH3+])c1ncc(-c2ccc(C)o2)[nH]1 by adding a benzene ring.,CC[C@](C)([NH3+])c1ncc(-c2ccc(C)o2)[nH]1,benzene ring
75062,Add a amine to the molecule CC[C@@H](OC)C(=O)N[C@H](C)c1ccc(F)cc1F.,CC[C@@H](OC)C(=O)N[C@H](C)c1ccc(F)cc1F,amine
133550,Modify the molecule Cc1cc(C(=O)CS[C@H](C)C(C)C)c(C)n1[C@@H]1CCS(=O)(=O)C1 by adding a benzene ring.,Cc1cc(C(=O)CS[C@H](C)C(C)C)c(C)n1[C@@H]1CCS(=O)(=O)C1,benzene ring
227920,Modify the molecule C[C@@H](NC(=O)Cc1cccc(OCc2cccnc2)c1)c1ccccc1 by adding a hydroxyl.,C[C@@H](NC(=O)Cc1cccc(OCc2cccnc2)c1)c1ccccc1,hydroxyl
109475,Modify the molecule C#CC[C@H](OC(=O)/C=C/c1ccc([C@H]2C[C@@H]2C)o1)c1ccccn1 by adding a halo.,C#CC[C@H](OC(=O)/C=C/c1ccc([C@H]2C[C@@H]2C)o1)c1ccccn1,halo
113478,Modify the molecule CCCS(=O)(=O)[N-]c1cccc(C(=O)N2CCC[C@@H]2c2ccc[nH]2)c1 by adding a aldehyde.,CCCS(=O)(=O)[N-]c1cccc(C(=O)N2CCC[C@@H]2c2ccc[nH]2)c1,aldehyde
185560,Modify the molecule CC[C@@H]1CCC[C@@H]([C@](C)(O)C2(C)CC2)C1 by adding a hydroxyl.,CC[C@@H]1CCC[C@@H]([C@](C)(O)C2(C)CC2)C1,hydroxyl
158842,Modify the molecule CC[NH+]1CCC[C@@H]1CNC(=O)CN1C(=O)c2ccccc2C1=O by adding a benzene ring.,CC[NH+]1CCC[C@@H]1CNC(=O)CN1C(=O)c2ccccc2C1=O,benzene ring
244760,Add a amine to the molecule CC[C@@H](NC(=O)NCc1ncn(C)n1)[C@@H]1CCCO1.,CC[C@@H](NC(=O)NCc1ncn(C)n1)[C@@H]1CCCO1,amine
120852,Add a amide to the molecule Cc1cc(NC(=O)CSc2nccn2-c2cccc(F)c2)no1.,Cc1cc(NC(=O)CSc2nccn2-c2cccc(F)c2)no1,amide
180390,Modify the molecule CN(C(=O)CCc1c[nH]c2ccccc12)[C@H]1CCc2ccccc2C1 by adding a hydroxyl.,CN(C(=O)CCc1c[nH]c2ccccc12)[C@H]1CCc2ccccc2C1,hydroxyl
112222,Please add a benzene ring to the molecule C/[NH+]=C(/NC[C@H]1CCC[NH+](C)C1)N1CCN(Cc2cccc(Cl)c2)CC1.,C/[NH+]=C(/NC[C@H]1CCC[NH+](C)C1)N1CCN(Cc2cccc(Cl)c2)CC1,benzene ring
49297,Modify the molecule NC(=O)[C@H]1CCCCN1S(=O)(=O)NCc1ccccc1 by adding a hydroxyl.,NC(=O)[C@H]1CCCCN1S(=O)(=O)NCc1ccccc1,hydroxyl
86317,Please add a hydroxyl to the molecule COc1cccc(-c2nnc(NC(=O)C3CC3)o2)c1.,COc1cccc(-c2nnc(NC(=O)C3CC3)o2)c1,hydroxyl
73777,Please add a benzene ring to the molecule CCc1cccc(N2C(=O)c3c(C(=O)OC)ncn3C[C@]2(C)C(=O)NC2CCCCC2)c1.,CCc1cccc(N2C(=O)c3c(C(=O)OC)ncn3C[C@]2(C)C(=O)NC2CCCCC2)c1,benzene ring
124305,Please add a nitro to the molecule CC(C)OC[C@@H]1CCC[C@H]([NH3+])C1.,CC(C)OC[C@@H]1CCC[C@H]([NH3+])C1,nitro
137173,Add a amide to the molecule Cn1cc(S(=O)(=O)N2CCC(C(=O)Nc3ncccn3)CC2)cc1C(N)=O.,Cn1cc(S(=O)(=O)N2CCC(C(=O)Nc3ncccn3)CC2)cc1C(N)=O,amide
56435,Please add a halo to the molecule CCc1cc(Cn2ccc([C@H]([NH3+])CC)c2)n(C)n1.,CCc1cc(Cn2ccc([C@H]([NH3+])CC)c2)n(C)n1,halo
69665,Add a hydroxyl to the molecule Cc1ccnn1[C@H](C)C(=O)N1CCC2(CC1)NC(=O)N(Cc1ccccc1)C2=O.,Cc1ccnn1[C@H](C)C(=O)N1CCC2(CC1)NC(=O)N(Cc1ccccc1)C2=O,hydroxyl
48611,Add a nitro to the molecule CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1.,CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1,nitro
221911,Add a benzene ring to the molecule Cc1ccc(NC(=O)CSC2=N[C@H]3CS(=O)(=O)C[C@@H]3N2c2cccc(Cl)c2)c(C)c1.,Cc1ccc(NC(=O)CSC2=N[C@H]3CS(=O)(=O)C[C@@H]3N2c2cccc(Cl)c2)c(C)c1,benzene ring
36603,Modify the molecule O=C1CCC(=O)N1CCSc1ncc(-c2ccc(F)cc2)[nH]1 by adding a benzene ring.,O=C1CCC(=O)N1CCSc1ncc(-c2ccc(F)cc2)[nH]1,benzene ring
180496,Please add a benzene ring to the molecule S=C1[NH+]=N[C@H](c2cccc[nH+]2)N1/N=C/c1ccc(Cl)c(Cl)c1.,S=C1[NH+]=N[C@H](c2cccc[nH+]2)N1/N=C/c1ccc(Cl)c(Cl)c1,benzene ring
132716,Please add a hydroxyl to the molecule C[C@H]1CN(Cc2cccc(OC(F)F)c2)C(C)(C)CO1.,C[C@H]1CN(Cc2cccc(OC(F)F)c2)C(C)(C)CO1,hydroxyl
194450,Add a hydroxyl to the molecule O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1.,O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1,hydroxyl
415,Add a amide to the molecule Cc1oc(-c2ccccc2)nc1CCNC(=O)c1ccc([S@@](C)=O)cc1.,Cc1oc(-c2ccccc2)nc1CCNC(=O)c1ccc([S@@](C)=O)cc1,amide
8919,Add a carboxyl to the molecule C=CCOC(=O)c1ccccc1C(=O)Nc1ccc(Cl)cc1Cl.,C=CCOC(=O)c1ccccc1C(=O)Nc1ccc(Cl)cc1Cl,carboxyl
152928,Please add a hydroxyl to the molecule CC(=O)N1CCCC[C@@H]1C[NH+](C)CCO.,CC(=O)N1CCCC[C@@H]1C[NH+](C)CCO,hydroxyl
231626,Modify the molecule Cc1ccc(-c2n[nH]cc2CN(C)[C@H](C)CS(C)(=O)=O)cc1 by adding a benzene ring.,Cc1ccc(-c2n[nH]cc2CN(C)[C@H](C)CS(C)(=O)=O)cc1,benzene ring
211097,Modify the molecule CC(C)OC(=O)N1CCC(NC(=O)Cc2ccc(F)c(F)c2)CC1 by adding a carboxyl.,CC(C)OC(=O)N1CCC(NC(=O)Cc2ccc(F)c(F)c2)CC1,carboxyl
136977,Modify the molecule CCN(CCC#N)C(=O)c1cc2ccc(OC)cc2[nH]1 by adding a benzene ring.,CCN(CCC#N)C(=O)c1cc2ccc(OC)cc2[nH]1,benzene ring
97199,Please add a benzene ring to the molecule CCC(=O)Nc1ccc(/N=C/c2c(Cl)cccc2Cl)cc1.,CCC(=O)Nc1ccc(/N=C/c2c(Cl)cccc2Cl)cc1,benzene ring
103170,Add a hydroxyl to the molecule O=C(Nc1ccccc1C(=O)N1CCOCC1)[C@H]1CCCN(C(=O)N2CCCC2)C1.,O=C(Nc1ccccc1C(=O)N1CCOCC1)[C@H]1CCCN(C(=O)N2CCCC2)C1,hydroxyl
228554,Modify the molecule CCc1ccc([N-]S(=O)(=O)c2cc(N)cc(Cl)c2F)cc1 by adding a amide.,CCc1ccc([N-]S(=O)(=O)c2cc(N)cc(Cl)c2F)cc1,amide
45067,Please add a benzene ring to the molecule Cc1ccncc1NC(=O)N[C@@H]1C[C@@H]1C1CCCCC1.,Cc1ccncc1NC(=O)N[C@@H]1C[C@@H]1C1CCCCC1,benzene ring
70911,Add a benzene ring to the molecule O=c1[nH]c([O-])nc(/C=C/c2cccc(OCc3ccccc3F)c2)c1[N+](=O)[O-].,O=c1[nH]c([O-])nc(/C=C/c2cccc(OCc3ccccc3F)c2)c1[N+](=O)[O-],benzene ring
132153,Please add a hydroxyl to the molecule O=C(c1ccccc1)c1ccc2n1CC[C@H]2C(=O)NC(CO)(CO)CO.,O=C(c1ccccc1)c1ccc2n1CC[C@H]2C(=O)NC(CO)(CO)CO,hydroxyl
62232,Please add a aldehyde to the molecule N#Cc1cc(-c2nc(-c3ccccc3)cs2)c(N)nc1SCC(=O)N1CCCCCC1.,N#Cc1cc(-c2nc(-c3ccccc3)cs2)c(N)nc1SCC(=O)N1CCCCCC1,aldehyde
191216,Modify the molecule Cc1ccc(OCC(=O)NNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1C by adding a hydroxyl.,Cc1ccc(OCC(=O)NNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1C,hydroxyl
14176,Add a aldehyde to the molecule Cc1ccc(CS[C@H]2[NH+]=c3ccc([N+](=O)[O-])cc3=[NH+]2)cc1.,Cc1ccc(CS[C@H]2[NH+]=c3ccc([N+](=O)[O-])cc3=[NH+]2)cc1,aldehyde
65676,Add a hydroxyl to the molecule Cc1nc2ccccc2n1CCC(=O)N1CCC([C@@]2(CCc3ccccc3)NC(=O)NC2=O)CC1.,Cc1nc2ccccc2n1CCC(=O)N1CCC([C@@]2(CCc3ccccc3)NC(=O)NC2=O)CC1,hydroxyl
45225,Please add a carboxyl to the molecule Nc1nnc(SC(Sc2nnc(N)s2)C(=O)c2ccccc2)s1.,Nc1nnc(SC(Sc2nnc(N)s2)C(=O)c2ccccc2)s1,carboxyl
137122,Modify the molecule CC(C)N(CCO)c1ncnc2c1CCCCC2 by adding a hydroxyl.,CC(C)N(CCO)c1ncnc2c1CCCCC2,hydroxyl
1202,Modify the molecule O=C(COC(=O)c1ccnnc1)Nc1ccc(C(F)(F)F)cc1 by adding a hydroxyl.,O=C(COC(=O)c1ccnnc1)Nc1ccc(C(F)(F)F)cc1,hydroxyl
3718,Modify the molecule COc1ccc(OC)c(NC(=O)Cc2csc(-c3cccc(F)c3)n2)c1 by adding a benzene ring.,COc1ccc(OC)c(NC(=O)Cc2csc(-c3cccc(F)c3)n2)c1,benzene ring
53994,Please add a aldehyde to the molecule CC[C@H](C)[C@@H](C)[NH2+][C@@H]1CCCn2nc(C)nc21.,CC[C@H](C)[C@@H](C)[NH2+][C@@H]1CCCn2nc(C)nc21,aldehyde
249345,Add a nitro to the molecule C[C@H](Nc1ccc2[nH]ccc2c1)c1cc(F)cc(F)c1.,C[C@H](Nc1ccc2[nH]ccc2c1)c1cc(F)cc(F)c1,nitro
184759,Add a benzene ring to the molecule CS(=O)(=O)N1CCCC[C@H]1C(=O)NCc1ccc(NC(=O)C2CC2)cc1.,CS(=O)(=O)N1CCCC[C@H]1C(=O)NCc1ccc(NC(=O)C2CC2)cc1,benzene ring
69712,Please add a amide to the molecule Cc1cc(C(=O)NCC(F)(F)F)sc1Br.,Cc1cc(C(=O)NCC(F)(F)F)sc1Br,amide
201751,Add a amide to the molecule CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1.,CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1,amide
193525,Add a hydroxyl to the molecule COc1ccc(Br)cc1S(=O)(=O)N(C)CC(=O)[O-].,COc1ccc(Br)cc1S(=O)(=O)N(C)CC(=O)[O-],hydroxyl
200105,Please add a hydroxyl to the molecule COC(=O)[C@H]1CCCC[C@H]1NC(=O)Cn1c(=O)oc2ccccc21.,COC(=O)[C@H]1CCCC[C@H]1NC(=O)Cn1c(=O)oc2ccccc21,hydroxyl
208940,Add a nitro to the molecule COC[C@H](O)C[NH+]1CCC(NC(=O)C[C@@H]2CCCC(C)(C)C2)CC1.,COC[C@H](O)C[NH+]1CCC(NC(=O)C[C@@H]2CCCC(C)(C)C2)CC1,nitro
199067,Add a hydroxyl to the molecule O=C(Nc1cccc(-c2nnnn2C2CC2)c1)c1cncc(Br)c1.,O=C(Nc1cccc(-c2nnnn2C2CC2)c1)c1cncc(Br)c1,hydroxyl
206561,Modify the molecule CC[C@H](C)NC(=O)[C@H](NC(=O)c1ccccc1Cl)C1CCN(C(C)=O)CC1 by adding a amide.,CC[C@H](C)NC(=O)[C@H](NC(=O)c1ccccc1Cl)C1CCN(C(C)=O)CC1,amide
109390,Please add a carboxyl to the molecule Cc1ccc(N[C@H]2c3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1F.,Cc1ccc(N[C@H]2c3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1F,carboxyl
26947,Please add a aldehyde to the molecule Cc1nn(CCO)c(C)c1C[NH+]1CC[C@@H](C)C[C@@H]1C.,Cc1nn(CCO)c(C)c1C[NH+]1CC[C@@H](C)C[C@@H]1C,aldehyde
204258,Add a hydroxyl to the molecule Cc1nnc2ccc(Nc3ccc4c(c3)N(C)C(=O)CO4)nn12.,Cc1nnc2ccc(Nc3ccc4c(c3)N(C)C(=O)CO4)nn12,hydroxyl
200954,Add a benzene ring to the molecule CCOC(=O)[C@H]1C=CNC(=O)[C@@H]1O.,CCOC(=O)[C@H]1C=CNC(=O)[C@@H]1O,benzene ring
16077,Add a halo to the molecule Cc1cc(Br)cc(C)c1NC(=O)c1ccc2cc[nH]c2c1.,Cc1cc(Br)cc(C)c1NC(=O)c1ccc2cc[nH]c2c1,halo
197860,Add a amide to the molecule C=CCN1C(=O)[C@]2(c3ccccc31)[C@H]1CCCC=C1C(C#N)=C(N)C2(C#N)C#N.,C=CCN1C(=O)[C@]2(c3ccccc31)[C@H]1CCCC=C1C(C#N)=C(N)C2(C#N)C#N,amide
49847,Modify the molecule CSC1=N/C(=C/c2ccc(Cl)cc2)C(=O)N1Cc1ccco1 by adding a benzene ring.,CSC1=N/C(=C/c2ccc(Cl)cc2)C(=O)N1Cc1ccco1,benzene ring
205852,Please add a benzene ring to the molecule Cc1nc(CN2CCN(C(=O)[C@@H]3CCO[C@@H]3C)CC2)n[nH]1.,Cc1nc(CN2CCN(C(=O)[C@@H]3CCO[C@@H]3C)CC2)n[nH]1,benzene ring
236787,Please add a nitrile to the molecule CN(C)c1ncc(-c2ccc(F)cc2)c([C@@H]2CCCN(S(=O)(=O)N(C)C)C2)n1.,CN(C)c1ncc(-c2ccc(F)cc2)c([C@@H]2CCCN(S(=O)(=O)N(C)C)C2)n1,nitrile
167660,Modify the molecule C/C=C/c1ccc(OC(=O)[C@@H]2C[C@H]2OCC)c(OC)c1 by adding a benzene ring.,C/C=C/c1ccc(OC(=O)[C@@H]2C[C@H]2OCC)c(OC)c1,benzene ring
159413,Add a benzene ring to the molecule COc1nc(C(=O)N(C)OC)cc2ccccc12.,COc1nc(C(=O)N(C)OC)cc2ccccc12,benzene ring
164767,Add a hydroxyl to the molecule CC(=O)N1CCC([NH+]2CCC(CO)(Cc3ccccc3Cl)CC2)CC1.,CC(=O)N1CCC([NH+]2CCC(CO)(Cc3ccccc3Cl)CC2)CC1,hydroxyl
103431,Add a benzene ring to the molecule CCCCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cccc(F)c1.,CCCCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cccc(F)c1,benzene ring
125772,Add a hydroxyl to the molecule CC(=O)NC[C@H](c1ccco1)S(=O)(=O)c1ccccc1.,CC(=O)NC[C@H](c1ccco1)S(=O)(=O)c1ccccc1,hydroxyl
5079,Please add a halo to the molecule C[C@@H](Nc1cccc(C(N)=O)c1)C(=O)Nc1ccc(Cl)cc1Cl.,C[C@@H](Nc1cccc(C(N)=O)c1)C(=O)Nc1ccc(Cl)cc1Cl,halo
9512,Add a benzene ring to the molecule Cc1ccc([C@@H]2CCC[NH+]2Cc2ccc(S(=O)(=O)N(C)C)o2)cc1C.,Cc1ccc([C@@H]2CCC[NH+]2Cc2ccc(S(=O)(=O)N(C)C)o2)cc1C,benzene ring
985,Modify the molecule CC[C@@H](C)c1ccccc1N1C[C@H](C(=O)N2CCN(C)CC2)CC1=O by adding a hydroxyl.,CC[C@@H](C)c1ccccc1N1C[C@H](C(=O)N2CCN(C)CC2)CC1=O,hydroxyl
72355,Add a nitro to the molecule COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C.,COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C,nitro
173289,Please add a aldehyde to the molecule O=C(Nc1ccccn1)c1ccnc(OC2CCC2)c1.,O=C(Nc1ccccn1)c1ccnc(OC2CCC2)c1,aldehyde
124897,Add a amine to the molecule COc1ccc(-c2nc3cc(NC(=O)c4ccccc4F)ccc3o2)cc1.,COc1ccc(-c2nc3cc(NC(=O)c4ccccc4F)ccc3o2)cc1,amine
42863,Modify the molecule CC[C@@H](C)[NH2+][C@H]1C=C[C@@H](C(=O)[O-])C1 by adding a carboxyl.,CC[C@@H](C)[NH2+][C@H]1C=C[C@@H](C(=O)[O-])C1,carboxyl
22017,Please add a benzene ring to the molecule COC1(NC(=O)c2ccc([N+](=O)[O-])cc2)C(C)=CC(=O)C=C1C.,COC1(NC(=O)c2ccc([N+](=O)[O-])cc2)C(C)=CC(=O)C=C1C,benzene ring
98850,Add a benzene ring to the molecule N#Cc1ccc(-c2cn3cccnc3n2)cc1.,N#Cc1ccc(-c2cn3cccnc3n2)cc1,benzene ring
30896,Please add a carboxyl to the molecule CCOc1cccc(NC(=O)NCCNC(=O)c2ccccc2Cl)c1.,CCOc1cccc(NC(=O)NCCNC(=O)c2ccccc2Cl)c1,carboxyl
237726,Add a halo to the molecule COc1ccc(C)cc1N1C[C@@H](C(=O)NNC(=O)c2cccs2)CC1=O.,COc1ccc(C)cc1N1C[C@@H](C(=O)NNC(=O)c2cccs2)CC1=O,halo
36676,Modify the molecule O=C(NCCN1CCc2ccccc21)[C@@H]1CCC[NH+](C2CCOCC2)C1 by adding a amine.,O=C(NCCN1CCc2ccccc21)[C@@H]1CCC[NH+](C2CCOCC2)C1,amine
34634,Modify the molecule COc1ccc2nc(-n3nc(C)c4c3NC(=O)C[C@@H]4c3ccc(F)c(F)c3)sc2c1 by adding a nitro.,COc1ccc2nc(-n3nc(C)c4c3NC(=O)C[C@@H]4c3ccc(F)c(F)c3)sc2c1,nitro
216102,Modify the molecule O=C(CNC1=NS(=O)(=O)c2ccccc21)N1CCC[C@H]1CCc1ccccc1 by adding a nitro.,O=C(CNC1=NS(=O)(=O)c2ccccc21)N1CCC[C@H]1CCc1ccccc1,nitro
192574,Modify the molecule CN(Cc1[nH+]ccn1C)C(=O)c1cc(S(C)(=O)=O)ccc1Cl by adding a hydroxyl.,CN(Cc1[nH+]ccn1C)C(=O)c1cc(S(C)(=O)=O)ccc1Cl,hydroxyl
179694,Modify the molecule O=C(/C=C/c1ccc([N+](=O)[O-])cc1)NNC(=O)c1ccc(Cl)cc1Cl by adding a carboxyl.,O=C(/C=C/c1ccc([N+](=O)[O-])cc1)NNC(=O)c1ccc(Cl)cc1Cl,carboxyl
1081,Modify the molecule Cc1cscc1C[NH2+]C[C@@H](O)C[NH+]1CCCC1 by adding a benzene ring.,Cc1cscc1C[NH2+]C[C@@H](O)C[NH+]1CCCC1,benzene ring
17030,Add a hydroxyl to the molecule C/[NH+]=C(\NCc1cccc(C)c1)NCc1ccc(C)s1.,C/[NH+]=C(\NCc1cccc(C)c1)NCc1ccc(C)s1,hydroxyl
74616,Add a amide to the molecule CC(C)(C)Oc1ccc(C(=O)NCC(=O)Nc2cccnc2)cc1.,CC(C)(C)Oc1ccc(C(=O)NCC(=O)Nc2cccnc2)cc1,amide
62156,Modify the molecule O=[S@@](Cc1nc(-c2ccsc2)no1)C(c1ccccc1)c1ccccc1 by adding a hydroxyl.,O=[S@@](Cc1nc(-c2ccsc2)no1)C(c1ccccc1)c1ccccc1,hydroxyl
180602,Modify the molecule O=C(Nc1ccc(Br)cc1)c1ccc(CSC2=NCCS2)cc1 by adding a nitro.,O=C(Nc1ccc(Br)cc1)c1ccc(CSC2=NCCS2)cc1,nitro
162064,Please add a amide to the molecule O=C1CCCN1CCN1CCCc2c1cccc2[N+](=O)[O-].,O=C1CCCN1CCN1CCCc2c1cccc2[N+](=O)[O-],amide
149118,Modify the molecule O=C(NC1=CC2=CC=N[C@@H]2C=C1)[C@@H]1SNN[C@@H]1c1ccccc1 by adding a amide.,O=C(NC1=CC2=CC=N[C@@H]2C=C1)[C@@H]1SNN[C@@H]1c1ccccc1,amide
84412,Please add a halo to the molecule O=C(CCn1nnc(-c2ccc(Cl)cc2)n1)NCc1ccccc1Cl.,O=C(CCn1nnc(-c2ccc(Cl)cc2)n1)NCc1ccccc1Cl,halo
211645,Modify the molecule c1ccc(-n2ncc(CNCCc3ccccn3)n2)cc1 by adding a hydroxyl.,c1ccc(-n2ncc(CNCCc3ccccn3)n2)cc1,hydroxyl
42090,Modify the molecule CCOc1cccc2sc(N(C[C@@H]3CCCO3)C(=O)c3ccc(C(C)=O)cc3)nc12 by adding a hydroxyl.,CCOc1cccc2sc(N(C[C@@H]3CCCO3)C(=O)c3ccc(C(C)=O)cc3)nc12,hydroxyl
174650,Add a nitro to the molecule CCn1nc(C)cc1NC(=O)c1cc(-c2ccc(OC)cc2)[nH]n1.,CCn1nc(C)cc1NC(=O)c1cc(-c2ccc(OC)cc2)[nH]n1,nitro
238952,Please add a benzene ring to the molecule NC(=O)Cn1c(C[NH+]2CCCCC2)nc2ccccc2c1=O.,NC(=O)Cn1c(C[NH+]2CCCCC2)nc2ccccc2c1=O,benzene ring
129792,Add a benzene ring to the molecule C/C(=N\c1ccc(C)cc1)c1ccc(O)cc1O.,C/C(=N\c1ccc(C)cc1)c1ccc(O)cc1O,benzene ring
148145,Modify the molecule O=C1C[C@@H]2C[C@H]1[C@H](C(=O)[O-])C2 by adding a hydroxyl.,O=C1C[C@@H]2C[C@H]1[C@H](C(=O)[O-])C2,hydroxyl
153988,Modify the molecule COc1ccc(S(=O)(=O)NCc2nc3cccnc3n2C2CC2)cc1 by adding a hydroxyl.,COc1ccc(S(=O)(=O)NCc2nc3cccnc3n2C2CC2)cc1,hydroxyl
208626,Please add a amide to the molecule CC(=O)NC[C@H]1CCCN(C(=O)c2cc(C)cc(Br)c2O)C1.,CC(=O)NC[C@H]1CCCN(C(=O)c2cc(C)cc(Br)c2O)C1,amide
214529,Please add a benzene ring to the molecule O=C(NCCCC(=O)N1CCN(c2cccc[nH+]2)CC1)NC1CCCCC1.,O=C(NCCCC(=O)N1CCN(c2cccc[nH+]2)CC1)NC1CCCCC1,benzene ring
179398,Modify the molecule CCCN[C@]1(C#N)CCC[C@@H](OCC)C1 by adding a halo.,CCCN[C@]1(C#N)CCC[C@@H](OCC)C1,halo
58035,Add a amide to the molecule Cc1csc(SCC(=O)N2CC[C@]3(CCCN(CC4CC4)C3=O)C2)n1.,Cc1csc(SCC(=O)N2CC[C@]3(CCCN(CC4CC4)C3=O)C2)n1,amide
82559,Please add a nitro to the molecule C[C@H](C1CC1)N(C)C(=O)c1ccc(-c2ccc(Cl)cc2)o1.,C[C@H](C1CC1)N(C)C(=O)c1ccc(-c2ccc(Cl)cc2)o1,nitro
45557,Please add a aldehyde to the molecule COc1cc2c(cc1C[NH+]1C[C@@H]3[C@@H](CC[C@@]3(O)c3ncccc3C)C1)CCCC2.,COc1cc2c(cc1C[NH+]1C[C@@H]3[C@@H](CC[C@@]3(O)c3ncccc3C)C1)CCCC2,aldehyde
214838,Add a benzene ring to the molecule COc1ccc(C)cc1NC(=O)C[NH+](C1CC1)[C@H](C)c1ccco1.,COc1ccc(C)cc1NC(=O)C[NH+](C1CC1)[C@H](C)c1ccco1,benzene ring
243955,Please add a aldehyde to the molecule C[NH+](Cc1nc(-c2ccc(Cl)cc2)no1)C1CC(C)(C)[NH2+]C(C)(C)C1.,C[NH+](Cc1nc(-c2ccc(Cl)cc2)no1)C1CC(C)(C)[NH2+]C(C)(C)C1,aldehyde
230832,Add a amine to the molecule Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(Br)c1.,Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(Br)c1,amine
46002,Please add a nitro to the molecule CCC(=O)N1CC[C@@H](C(=O)O[C@@H]2C=C(c3ccc(Cl)cc3)CC2)C1.,CCC(=O)N1CC[C@@H](C(=O)O[C@@H]2C=C(c3ccc(Cl)cc3)CC2)C1,nitro
212151,Please add a benzene ring to the molecule CC1(C)CCN(C(=O)C2(C(N)=S)CCCC2)C1.,CC1(C)CCN(C(=O)C2(C(N)=S)CCCC2)C1,benzene ring
176967,Please add a nitro to the molecule CC(=O)c1ccccc1OC(F)(F)[C@H](F)Cl.,CC(=O)c1ccccc1OC(F)(F)[C@H](F)Cl,nitro
188047,Please add a benzene ring to the molecule N#CC1=C(N)Oc2n[nH]c(-c3ccc(F)cc3)c2[C@@H]1c1ccc(Br)s1.,N#CC1=C(N)Oc2n[nH]c(-c3ccc(F)cc3)c2[C@@H]1c1ccc(Br)s1,benzene ring
167229,Add a halo to the molecule Cc1cc(C(=O)Nc2sc3c(c2C(N)=O)CC[C@H](C)C3)ccc1[N+](=O)[O-].,Cc1cc(C(=O)Nc2sc3c(c2C(N)=O)CC[C@H](C)C3)ccc1[N+](=O)[O-],halo
31090,Modify the molecule CC[C@@H](Nc1nncc(-c2ccccc2F)n1)c1nc2cc(C)ccc2[nH]1 by adding a benzene ring.,CC[C@@H](Nc1nncc(-c2ccccc2F)n1)c1nc2cc(C)ccc2[nH]1,benzene ring
229391,Add a nitro to the molecule CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1.,CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1,nitro
20981,Please add a hydroxyl to the molecule O=C(NC[C@H](c1cccs1)N1CCOCC1)Nc1cccc(Cl)c1.,O=C(NC[C@H](c1cccs1)N1CCOCC1)Nc1cccc(Cl)c1,hydroxyl
111569,Please add a amide to the molecule CC[C@@H](C)[C@H]1NC(=O)CN(c2ccc(Cl)c(Br)c2)C1=O.,CC[C@@H](C)[C@H]1NC(=O)CN(c2ccc(Cl)c(Br)c2)C1=O,amide
209526,Add a hydroxyl to the molecule Cc1ccccc1[C@H](C)NC(=O)C(=O)Nc1ccccc1CC(N)=O.,Cc1ccccc1[C@H](C)NC(=O)C(=O)Nc1ccccc1CC(N)=O,hydroxyl
65423,Modify the molecule CCc1ncc(C[NH2+]CC2CCC(C(N)=O)CC2)s1 by adding a hydroxyl.,CCc1ncc(C[NH2+]CC2CCC(C(N)=O)CC2)s1,hydroxyl
108443,Modify the molecule CC(C)c1ccc(NC[C@H](C)C(N)=O)cc1 by adding a carboxyl.,CC(C)c1ccc(NC[C@H](C)C(N)=O)cc1,carboxyl
149489,Modify the molecule O=C(NCCN1CCN(c2ccccc2F)CC1)C1CCN(c2ccc(N3CCCCC3)nn2)CC1 by adding a hydroxyl.,O=C(NCCN1CCN(c2ccccc2F)CC1)C1CCN(c2ccc(N3CCCCC3)nn2)CC1,hydroxyl
143696,Add a amine to the molecule CCc1noc(C)c1C(=O)N(C)Cc1cc(Cl)cc(Cl)c1.,CCc1noc(C)c1C(=O)N(C)Cc1cc(Cl)cc(Cl)c1,amine
131570,Please add a benzene ring to the molecule COc1ccc(S(=O)(=O)N2Cc3ccccc3OC3(CCOCC3)C2)cc1.,COc1ccc(S(=O)(=O)N2Cc3ccccc3OC3(CCOCC3)C2)cc1,benzene ring
232605,Please add a hydroxyl to the molecule CC(=O)C1=C(C)C(C(=O)N[C@H](Cc2ncc[nH]2)c2ccccc2)=N[C@@H]1C.,CC(=O)C1=C(C)C(C(=O)N[C@H](Cc2ncc[nH]2)c2ccccc2)=N[C@@H]1C,hydroxyl
110830,Please add a nitro to the molecule COCC[NH2+]C[C@@H]1CCCCN1c1ccc(C(N)=O)nn1.,COCC[NH2+]C[C@@H]1CCCCN1c1ccc(C(N)=O)nn1,nitro
202352,Add a nitro to the molecule Cc1ccc([C@@](O)(CC(=O)N(C)CCc2ccncc2)C(F)(F)F)o1.,Cc1ccc([C@@](O)(CC(=O)N(C)CCc2ccncc2)C(F)(F)F)o1,nitro
156525,Please add a hydroxyl to the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCC(=O)N1CCCC1.,CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCC(=O)N1CCCC1,hydroxyl
243961,Modify the molecule Cc1ccc(C(=O)NC2CCN(C(=O)[C@@H](C)c3ccsc3)CC2)s1 by adding a hydroxyl.,Cc1ccc(C(=O)NC2CCN(C(=O)[C@@H](C)c3ccsc3)CC2)s1,hydroxyl
78662,Add a aldehyde to the molecule CC[C@@H](C)NC(=O)[C@@H](C)[NH+](C)Cc1sccc1C.,CC[C@@H](C)NC(=O)[C@@H](C)[NH+](C)Cc1sccc1C,aldehyde
137024,Please add a benzene ring to the molecule CCC[C@H]1CN(C(=O)Nc2ccc(CC)c(F)c2)CCO1.,CCC[C@H]1CN(C(=O)Nc2ccc(CC)c(F)c2)CCO1,benzene ring
32370,Add a amide to the molecule COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12.,COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12,amide
146115,Please add a amine to the molecule COc1cc(CN2CC[NH+](Cc3ccccn3)CC2)cc(OC)c1O.,COc1cc(CN2CC[NH+](Cc3ccccn3)CC2)cc(OC)c1O,amine
74852,Modify the molecule CC/C(=N\NC(=O)[C@@H]1C[C@@H]1c1ccccc1)c1cccc(Cl)c1 by adding a hydroxyl.,CC/C(=N\NC(=O)[C@@H]1C[C@@H]1c1ccccc1)c1cccc(Cl)c1,hydroxyl
181448,Add a amide to the molecule CC[NH2+][C@](C)(CCN1C[C@@H]2CCC[NH+]2C[C@@H]1C)C(N)=O.,CC[NH2+][C@](C)(CCN1C[C@@H]2CCC[NH+]2C[C@@H]1C)C(N)=O,amide
191394,Modify the molecule Cc1ccc(S(=O)(=O)NC2CCCCC2)cc1F by adding a amide.,Cc1ccc(S(=O)(=O)NC2CCCCC2)cc1F,amide
32859,Modify the molecule CCSC[C@H](C)N(C)C(=O)[C@@H](C)Cc1c(C)noc1C by adding a nitro.,CCSC[C@H](C)N(C)C(=O)[C@@H](C)Cc1c(C)noc1C,nitro
7477,Please add a aldehyde to the molecule CCOc1ccc2nc(NC(=O)C[NH+]3[C@H]4CC[C@@H]3CNC(=O)C4)sc2c1.,CCOc1ccc2nc(NC(=O)C[NH+]3[C@H]4CC[C@@H]3CNC(=O)C4)sc2c1,aldehyde
59467,Add a aldehyde to the molecule CC(C)c1ccc([C@H](NC(=O)N(C)C2CCS(=O)CC2)C(C)C)cc1.,CC(C)c1ccc([C@H](NC(=O)N(C)C2CCS(=O)CC2)C(C)C)cc1,aldehyde
98335,Add a aldehyde to the molecule Clc1ccc2nc(NC3CCCCC3)sc2c1.,Clc1ccc2nc(NC3CCCCC3)sc2c1,aldehyde
107872,Please add a hydroxyl to the molecule CC1=NO[C@@H](CNC(=O)c2ccccc2F)C1.,CC1=NO[C@@H](CNC(=O)c2ccccc2F)C1,hydroxyl
18219,Add a benzene ring to the molecule CCn1c(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc2ccccc21.,CCn1c(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc2ccccc21,benzene ring
128161,Modify the molecule O=[N+]([O-])c1cccnc1N1CCC2(CC1)OCCO2 by adding a halo.,O=[N+]([O-])c1cccnc1N1CCC2(CC1)OCCO2,halo
101492,Add a carboxyl to the molecule C=CCONC(=O)Nc1ccc(Cl)cc1.,C=CCONC(=O)Nc1ccc(Cl)cc1,carboxyl
83902,Modify the molecule C[C@H]([NH2+][C@H](CO)c1ccccc1F)c1ccc(Cl)c(Cl)c1 by adding a amide.,C[C@H]([NH2+][C@H](CO)c1ccccc1F)c1ccc(Cl)c(Cl)c1,amide
206162,Modify the molecule O=C(C[NH+]1CCC[C@H](O)C1)N(Cc1ccc(F)cc1)C12CC3CC(CC(C3)C1)C2 by adding a amide.,O=C(C[NH+]1CCC[C@H](O)C1)N(Cc1ccc(F)cc1)C12CC3CC(CC(C3)C1)C2,amide
84475,Modify the molecule CCN(C[C@H]1CCCO1)C(=O)c1cnc2ccc(C)cn12 by adding a benzene ring.,CCN(C[C@H]1CCCO1)C(=O)c1cnc2ccc(C)cn12,benzene ring
92026,Modify the molecule COC[C@H](O)CC[NH2+][C@@H]1CCc2ccc(OC)cc2C1 by adding a amide.,COC[C@H](O)CC[NH2+][C@@H]1CCc2ccc(OC)cc2C1,amide
62563,Add a hydroxyl to the molecule c1ccc2c(c1)C[C@H](C[NH2+]C[C@@H]1CN3CCC[C@@H]3CO1)O2.,c1ccc2c(c1)C[C@H](C[NH2+]C[C@@H]1CN3CCC[C@@H]3CO1)O2,hydroxyl
37573,Add a halo to the molecule CC(C)(CCO)c1cc(Cl)sc1Cl.,CC(C)(CCO)c1cc(Cl)sc1Cl,halo
201013,Please add a hydroxyl to the molecule CC[NH+]1CCC[C@H]1CN(C)C(=O)c1ccc(NC)cc1.,CC[NH+]1CCC[C@H]1CN(C)C(=O)c1ccc(NC)cc1,hydroxyl
81884,Please add a aldehyde to the molecule Cc1ccc(NC(=O)C2CC[NH+](Cn3nc(C4CC4)n(Cc4ccccc4)c3=S)CC2)nc1.,Cc1ccc(NC(=O)C2CC[NH+](Cn3nc(C4CC4)n(Cc4ccccc4)c3=S)CC2)nc1,aldehyde
184262,Add a halo to the molecule N#CC1(NC(=O)C[NH+](CCc2ccccc2)[C@H]2CCOC2)CCCCCC1.,N#CC1(NC(=O)C[NH+](CCc2ccccc2)[C@H]2CCOC2)CCCCCC1,halo
37366,Modify the molecule COc1ccccc1[C@H](C)[NH2+]CC(=O)Nc1ccc(C(F)(F)F)cc1 by adding a hydroxyl.,COc1ccccc1[C@H](C)[NH2+]CC(=O)Nc1ccc(C(F)(F)F)cc1,hydroxyl
221443,Add a amide to the molecule C[C@@H]1C[C@H]([NH2+][C@@H]2CC(=O)N(C)C2=O)CS1.,C[C@@H]1C[C@H]([NH2+][C@@H]2CC(=O)N(C)C2=O)CS1,amide
187598,Modify the molecule [NH3+][C@@H](Cc1cccc(Br)c1)[C@@H]1CSCCS1 by adding a benzene ring.,[NH3+][C@@H](Cc1cccc(Br)c1)[C@@H]1CSCCS1,benzene ring
757,Modify the molecule CC[C@H](c1ccc(F)cc1)N(C)C(=O)Cn1nnc(-c2ccccc2)n1 by adding a thiol.,CC[C@H](c1ccc(F)cc1)N(C)C(=O)Cn1nnc(-c2ccccc2)n1,thiol
45404,Modify the molecule CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1 by adding a halo.,CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1,halo
157997,Please add a hydroxyl to the molecule COc1cccc2c1OC[C@@H](NC(=O)Nc1cncc3ccccc13)C2.,COc1cccc2c1OC[C@@H](NC(=O)Nc1cncc3ccccc13)C2,hydroxyl
116282,Add a carboxyl to the molecule O=C(NC1CCC(c2ccccc2)CC1)C1C[C@@H]2CCC[C@H](C1)C2=O.,O=C(NC1CCC(c2ccccc2)CC1)C1C[C@@H]2CCC[C@H](C1)C2=O,carboxyl
103667,Modify the molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)Nc1cc(F)ccc1F by adding a amine.,Cc1nn(Cc2ccccc2Cl)c(C)c1C(=O)Nc1cc(F)ccc1F,amine
243097,Please add a amide to the molecule O=C(c1ccc(-c2csc(C3CC3)n2)cc1)N1CCN(c2cccc(Cl)c2)CC1.,O=C(c1ccc(-c2csc(C3CC3)n2)cc1)N1CCN(c2cccc(Cl)c2)CC1,amide
119794,Add a amide to the molecule CCC(=O)c1ccc(OC[C@@H](O)C[NH+]2CCCC[C@@H]2C)cc1.,CCC(=O)c1ccc(OC[C@@H](O)C[NH+]2CCCC[C@@H]2C)cc1,amide
22649,Add a amine to the molecule C[C@@H](Cc1ccc(Br)cc1F)[C@H](C)[NH2+]C1CC1.,C[C@@H](Cc1ccc(Br)cc1F)[C@H](C)[NH2+]C1CC1,amine
173222,Modify the molecule Cc1[nH]c2ccc(-c3nnc(SCC(=O)N4CCN(c5ccccc5)CC4)o3)cc2c1C by adding a hydroxyl.,Cc1[nH]c2ccc(-c3nnc(SCC(=O)N4CCN(c5ccccc5)CC4)o3)cc2c1C,hydroxyl
111597,Add a nitro to the molecule O=c1oc2ccc([N+](=O)[O-])cc2n1CCCOc1cccc[n+]1[O-].,O=c1oc2ccc([N+](=O)[O-])cc2n1CCCOc1cccc[n+]1[O-],nitro
247284,Please add a nitro to the molecule COc1ccc(OC)c(NC(=O)c2cc(C)n(C3CC3)c2C)c1.,COc1ccc(OC)c(NC(=O)c2cc(C)n(C3CC3)c2C)c1,nitro
176376,Modify the molecule COc1ccc(S(=O)(=O)CC(=O)Nc2nc3c(s2)CCCC3)cc1 by adding a hydroxyl.,COc1ccc(S(=O)(=O)CC(=O)Nc2nc3c(s2)CCCC3)cc1,hydroxyl
38484,Modify the molecule CNC(=O)CN1C(=O)COc2ccc(C(C)(C)C)cc21 by adding a benzene ring.,CNC(=O)CN1C(=O)COc2ccc(C(C)(C)C)cc21,benzene ring
244341,Add a amide to the molecule Cc1ccc(OCCn2cnc3c(oc4ccccc43)c2=O)cc1.,Cc1ccc(OCCn2cnc3c(oc4ccccc43)c2=O)cc1,amide
17315,Please add a amine to the molecule CN(Cc1ccc(F)cc1)C[C@H]1CCC(C)(C)[C@@H]1[NH3+].,CN(Cc1ccc(F)cc1)C[C@H]1CCC(C)(C)[C@@H]1[NH3+],amine
102801,Modify the molecule O=C(Nc1cc2c(cc1Br)OCCO2)c1cc([N+](=O)[O-])ccc1Cl by adding a halo.,O=C(Nc1cc2c(cc1Br)OCCO2)c1cc([N+](=O)[O-])ccc1Cl,halo
51103,Please add a amide to the molecule Cc1cnc(-c2cccc(NC(=O)NCCCC[NH+]3CCC[C@@H](C)C3)c2)o1.,Cc1cnc(-c2cccc(NC(=O)NCCCC[NH+]3CCC[C@@H](C)C3)c2)o1,amide
198511,Add a hydroxyl to the molecule CC(C)(O)c1ccccc1C(C)(C)O.,CC(C)(O)c1ccccc1C(C)(C)O,hydroxyl
154604,Modify the molecule C[C@H](Sc1nnc(-c2ccc(F)cc2)c2ccccc12)C(=O)NC(N)=O by adding a nitro.,C[C@H](Sc1nnc(-c2ccc(F)cc2)c2ccccc12)C(=O)NC(N)=O,nitro
192604,Modify the molecule CCc1nncn1CCNC(=O)N1CCNC(=O)[C@@H]1C(C)C by adding a amine.,CCc1nncn1CCNC(=O)N1CCNC(=O)[C@@H]1C(C)C,amine
219971,Add a hydroxyl to the molecule N#CC1(C(=O)OC[C@H]2CCCCO2)CCCC1.,N#CC1(C(=O)OC[C@H]2CCCCO2)CCCC1,hydroxyl
242839,Please add a hydroxyl to the molecule O=C(/C=C/c1ccc([N+](=O)[O-])cc1)NCc1ccncc1.,O=C(/C=C/c1ccc([N+](=O)[O-])cc1)NCc1ccncc1,hydroxyl
163830,Add a aldehyde to the molecule Cc1cc(S(=O)(=O)N2CCN(C(=O)c3cc(C4CC4)nc4c3c(C)nn4C)CC2)c(C)s1.,Cc1cc(S(=O)(=O)N2CCN(C(=O)c3cc(C4CC4)nc4c3c(C)nn4C)CC2)c(C)s1,aldehyde
2065,Add a carboxyl to the molecule Cc1cc(C)c(O)c(C(=O)Nc2ccccc2N2CCOCC2)c1.,Cc1cc(C)c(O)c(C(=O)Nc2ccccc2N2CCOCC2)c1,carboxyl
39677,Please add a benzene ring to the molecule CCOc1ccc(N(Cc2nnc3n2CCCCC3)C(=O)Nc2cccc(Cl)c2)cc1.,CCOc1ccc(N(Cc2nnc3n2CCCCC3)C(=O)Nc2cccc(Cl)c2)cc1,benzene ring
167553,Add a aldehyde to the molecule O=C(CSc1ccncc1)Nc1cnc(-c2ccccc2)nc1.,O=C(CSc1ccncc1)Nc1cnc(-c2ccccc2)nc1,aldehyde
162976,Modify the molecule CC(C)c1nn(C)c2sc(C(=O)Nc3ccnc4ccnn34)cc12 by adding a hydroxyl.,CC(C)c1nn(C)c2sc(C(=O)Nc3ccnc4ccnn34)cc12,hydroxyl
80267,Please add a hydroxyl to the molecule Cc1cc(C)cc([C@H]2CCN(C(=O)OC(C)(C)C)C[C@@H]2[NH3+])c1.,Cc1cc(C)cc([C@H]2CCN(C(=O)OC(C)(C)C)C[C@@H]2[NH3+])c1,hydroxyl
144512,Please add a benzene ring to the molecule C[NH+](C)C1(CNC(=O)CNC(=O)N2CCc3ccccc3C2)CCOCC1.,C[NH+](C)C1(CNC(=O)CNC(=O)N2CCc3ccccc3C2)CCOCC1,benzene ring
171146,Add a hydroxyl to the molecule O=C(Nn1ccc2c(nnc3c(-c4ccc(F)cc4)cnn32)c1=O)c1ccc(Cl)cc1.,O=C(Nn1ccc2c(nnc3c(-c4ccc(F)cc4)cnn32)c1=O)c1ccc(Cl)cc1,hydroxyl
225226,Modify the molecule C[C@H](NC(=O)c1ccoc1)C(=O)O[C@@H](c1ccccc1)c1ccncc1 by adding a nitro.,C[C@H](NC(=O)c1ccoc1)C(=O)O[C@@H](c1ccccc1)c1ccncc1,nitro
86495,Add a benzene ring to the molecule Cc1nc(C2CCN(C(=O)N[C@H](C)c3ncc(C)s3)CC2)no1.,Cc1nc(C2CCN(C(=O)N[C@H](C)c3ncc(C)s3)CC2)no1,benzene ring
171844,Please add a benzene ring to the molecule CC(C)COC(=O)N1CCC[C@@H]1C(=O)Nc1ccc2c(c1)OCO2.,CC(C)COC(=O)N1CCC[C@@H]1C(=O)Nc1ccc2c(c1)OCO2,benzene ring
208946,Add a aldehyde to the molecule C[NH2+][C@H]1CCN(c2cccc(C(C)C)c2)C1.,C[NH2+][C@H]1CCN(c2cccc(C(C)C)c2)C1,aldehyde
126738,Modify the molecule C[C@H]1COC[C@@H](C)N1Cc1ccc([N+](=O)[O-])o1 by adding a thiol.,C[C@H]1COC[C@@H](C)N1Cc1ccc([N+](=O)[O-])o1,thiol
81832,Please add a amide to the molecule C[C@H]1CCCN(C(=O)NCc2ccc(C#CC[NH3+])cc2)C1.,C[C@H]1CCCN(C(=O)NCc2ccc(C#CC[NH3+])cc2)C1,amide
223966,Please add a aldehyde to the molecule C[C@H]1Cc2cc(F)c(F)c(F)c2[C@H]1Cl.,C[C@H]1Cc2cc(F)c(F)c(F)c2[C@H]1Cl,aldehyde
173301,Please add a amine to the molecule Cc1ccc(Cn2c(=O)c3ccccc3n3c(-c4ccc(C#N)cc4)nnc23)cc1.,Cc1ccc(Cn2c(=O)c3ccccc3n3c(-c4ccc(C#N)cc4)nnc23)cc1,amine
15724,Please add a carboxyl to the molecule C[C@@H](C[C@@H]1CCC[NH2+]1)[NH2+]C[C@]1(O)CCC[C@@H](C)C1.,C[C@@H](C[C@@H]1CCC[NH2+]1)[NH2+]C[C@]1(O)CCC[C@@H](C)C1,carboxyl
114796,Please add a aldehyde to the molecule O=C(CSc1nnc(Nc2cccc(F)c2)s1)N(c1ccccc1)[C@H]1CCS(=O)(=O)C1.,O=C(CSc1nnc(Nc2cccc(F)c2)s1)N(c1ccccc1)[C@H]1CCS(=O)(=O)C1,aldehyde
164807,Modify the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)CCCOc1ccc(Cl)cc1)CC2 by adding a benzene ring.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)CCCOc1ccc(Cl)cc1)CC2,benzene ring
77223,Modify the molecule CCn1c([C@@H]2CCC[NH2+]C2)nn(Cc2ncccn2)c1=O by adding a amide.,CCn1c([C@@H]2CCC[NH2+]C2)nn(Cc2ncccn2)c1=O,amide
45069,Modify the molecule O=C(CSc1nc2c(c(=O)n1-c1ccc(Br)cc1)SCC2)NCc1ccccc1 by adding a hydroxyl.,O=C(CSc1nc2c(c(=O)n1-c1ccc(Br)cc1)SCC2)NCc1ccccc1,hydroxyl
8542,Please add a hydroxyl to the molecule C#CCCN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1.,C#CCCN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1,hydroxyl
233723,Add a carboxyl to the molecule C[C@H](CNC(=O)c1[nH]nc(C2CC2)c1Cl)Oc1cccc(F)c1.,C[C@H](CNC(=O)c1[nH]nc(C2CC2)c1Cl)Oc1cccc(F)c1,carboxyl
231108,Please add a hydroxyl to the molecule CC[C@H](CO)[NH+]1CCN(Cc2cccc(F)c2Cl)CC1.,CC[C@H](CO)[NH+]1CCN(Cc2cccc(F)c2Cl)CC1,hydroxyl
206418,Add a nitro to the molecule C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1.,C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1,nitro
119894,Add a benzene ring to the molecule C[C@H](O)c1ccnc(S[C@@H]2CCC[C@@H](C)C2)c1.,C[C@H](O)c1ccnc(S[C@@H]2CCC[C@@H](C)C2)c1,benzene ring
231844,Add a benzene ring to the molecule C[C@H]1CCN(C(=O)CCCCc2ccc(Cl)c(Cl)c2)C[C@@H]1O.,C[C@H]1CCN(C(=O)CCCCc2ccc(Cl)c(Cl)c2)C[C@@H]1O,benzene ring
138438,Add a hydroxyl to the molecule CN(c1ccccc1)C1CCN(C(=O)c2c(O)cccc2O)CC1.,CN(c1ccccc1)C1CCN(C(=O)c2c(O)cccc2O)CC1,hydroxyl
91261,Modify the molecule C[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O by adding a nitro.,C[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O,nitro
180966,Modify the molecule O=C(Nc1nnc(-c2ccncc2)s1)c1cc2c(ccc3ccccc32)oc1=O by adding a benzene ring.,O=C(Nc1nnc(-c2ccncc2)s1)c1cc2c(ccc3ccccc32)oc1=O,benzene ring
201198,Modify the molecule COc1cc(Br)cc(CN(C)CCc2ncc(C)s2)c1O by adding a aldehyde.,COc1cc(Br)cc(CN(C)CCc2ncc(C)s2)c1O,aldehyde
202487,Please add a benzene ring to the molecule CC(C)Cn1c(SCC(=O)c2ccc3c(c2)CCCC3)nnc1N1CCOCC1.,CC(C)Cn1c(SCC(=O)c2ccc3c(c2)CCCC3)nnc1N1CCOCC1,benzene ring
15087,Modify the molecule O=C(Nc1ccccc1OCC(F)(F)F)N1CCC[C@@H]1c1cccc(F)c1 by adding a hydroxyl.,O=C(Nc1ccccc1OCC(F)(F)F)N1CCC[C@@H]1c1cccc(F)c1,hydroxyl
1349,Add a aldehyde to the molecule CC(C)(C)[C@@H](CS)C[NH+]1CCN(c2ccccc2Cl)CC1.,CC(C)(C)[C@@H](CS)C[NH+]1CCN(c2ccccc2Cl)CC1,aldehyde
192366,Modify the molecule O=C(CC[C@@H]1NC(=O)N(CCc2c[nH]c3ccc(F)cc23)C1=O)Nc1cccc(F)c1 by adding a carboxyl.,O=C(CC[C@@H]1NC(=O)N(CCc2c[nH]c3ccc(F)cc23)C1=O)Nc1cccc(F)c1,carboxyl
217387,Add a hydroxyl to the molecule CSCc1ccnc(NCc2ccc(N3CCc4ccccc4C3)[nH+]c2)c1.,CSCc1ccnc(NCc2ccc(N3CCc4ccccc4C3)[nH+]c2)c1,hydroxyl
38106,Modify the molecule COc1ccc(/C=N/NC(=O)c2ccc(C(C)(C)C)cc2)cc1O by adding a thiol.,COc1ccc(/C=N/NC(=O)c2ccc(C(C)(C)C)cc2)cc1O,thiol
240397,Modify the molecule COc1cc(CC(=O)NCc2cc(C(C)C)no2)ccc1C by adding a thiol.,COc1cc(CC(=O)NCc2cc(C(C)C)no2)ccc1C,thiol
202083,Please add a hydroxyl to the molecule Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1.,Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1,hydroxyl
97275,Modify the molecule C[C@@H](OC(=O)c1nc(C2CC2)n2ccccc12)C(=O)Nc1ccccc1 by adding a benzene ring.,C[C@@H](OC(=O)c1nc(C2CC2)n2ccccc12)C(=O)Nc1ccccc1,benzene ring
53061,Please add a benzene ring to the molecule O=C(c1ccc(O)cc1)C1CCN(C(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)CC1.,O=C(c1ccc(O)cc1)C1CCN(C(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)CC1,benzene ring
233105,Please add a amide to the molecule COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1.,COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1,amide
244622,Please add a benzene ring to the molecule CC(C)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl.,CC(C)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl,benzene ring
117275,Please add a carboxyl to the molecule CC(C)N1C[C@H](C(=O)N2CCC(N(C)c3ccccc3)CC2)CC1=O.,CC(C)N1C[C@H](C(=O)N2CCC(N(C)c3ccccc3)CC2)CC1=O,carboxyl
145884,Add a benzene ring to the molecule C#CCNC(=O)c1ccccc1NC(=O)c1nnn(-c2ccc(C)cc2)c1C.,C#CCNC(=O)c1ccccc1NC(=O)c1nnn(-c2ccc(C)cc2)c1C,benzene ring
217164,Please add a amide to the molecule O=C(Cc1ccc2ccccc2c1)N1CCN(c2nc3ccc(F)cc3s2)CC1.,O=C(Cc1ccc2ccccc2c1)N1CCN(c2nc3ccc(F)cc3s2)CC1,amide
159788,Add a hydroxyl to the molecule C[NH2+][C@H]1CCC[C@H]([NH+]2CCCC2)C1.,C[NH2+][C@H]1CCC[C@H]([NH+]2CCCC2)C1,hydroxyl
138837,Add a hydroxyl to the molecule CC(C)c1ccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3C[C@H]3C(=O)N(CCN4CCOCC4)CC(=O)N32)cc1.,CC(C)c1ccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3C[C@H]3C(=O)N(CCN4CCOCC4)CC(=O)N32)cc1,hydroxyl
172576,Add a amide to the molecule Cc1cccc(O[C@H](C)C(=O)Cl)c1.,Cc1cccc(O[C@H](C)C(=O)Cl)c1,amide
129006,Add a thiol to the molecule Cc1ccc(OCc2cn3cc(Br)ccc3n2)nc1.,Cc1ccc(OCc2cn3cc(Br)ccc3n2)nc1,thiol
156628,Please add a benzene ring to the molecule Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-].,Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-],benzene ring
131882,Please add a benzene ring to the molecule C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)NCCc1ccc(O)cc1.,C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)NCCc1ccc(O)cc1,benzene ring
38881,Modify the molecule CC[C@H](C)n1c([C@H](C)CC)nc2cc(C(=O)[O-])ccc21 by adding a hydroxyl.,CC[C@H](C)n1c([C@H](C)CC)nc2cc(C(=O)[O-])ccc21,hydroxyl
217498,Modify the molecule CC[C@@H]([NH2+][C@H](C)c1c(C)noc1C)C(=O)Nc1cc(C)on1 by adding a benzene ring.,CC[C@@H]([NH2+][C@H](C)c1c(C)noc1C)C(=O)Nc1cc(C)on1,benzene ring
41648,Please add a aldehyde to the molecule O=C(NCCC(=O)N1CCCCC1)Nc1cccc(N2CCCCCC2)c1.,O=C(NCCC(=O)N1CCCCC1)Nc1cccc(N2CCCCCC2)c1,aldehyde
145186,Add a benzene ring to the molecule Cc1cc(C)c2c(c1)/C(=N\NC(=O)[C@@H](C)SCc1ccccc1)C(=O)N2.,Cc1cc(C)c2c(c1)/C(=N\NC(=O)[C@@H](C)SCc1ccccc1)C(=O)N2,benzene ring
227320,Modify the molecule CCOC(=O)c1c(-c2ccc(F)cc2)csc1NC(=O)C[NH+]1CCCCC1 by adding a amide.,CCOC(=O)c1c(-c2ccc(F)cc2)csc1NC(=O)C[NH+]1CCCCC1,amide
77431,Please add a hydroxyl to the molecule Cc1ccc(C(=O)NC2CC[NH+](CC(=O)N[C@@H]3CCCC[C@H]3C)CC2)o1.,Cc1ccc(C(=O)NC2CC[NH+](CC(=O)N[C@@H]3CCCC[C@H]3C)CC2)o1,hydroxyl
176130,Modify the molecule CC(C)Oc1ccc(NC(=O)NCC(=O)NCc2ccccc2)cc1 by adding a amide.,CC(C)Oc1ccc(NC(=O)NCC(=O)NCc2ccccc2)cc1,amide
99764,Add a amide to the molecule COc1cc(NC(=O)c2cnc(C)cn2)ccc1NC(=O)C1CCCCC1.,COc1cc(NC(=O)c2cnc(C)cn2)ccc1NC(=O)C1CCCCC1,amide
157901,Please add a benzene ring to the molecule COc1ccc(OCC(=O)N2CCCSC[C@H]2C[NH+](C)C)cc1.,COc1ccc(OCC(=O)N2CCCSC[C@H]2C[NH+](C)C)cc1,benzene ring
80283,Add a aldehyde to the molecule COCCN1C[C@@]23C=C[C@@H](O2)[C@@H](C(=O)N(C)Cc2cc(C)on2)[C@H]3C1=O.,COCCN1C[C@@]23C=C[C@@H](O2)[C@@H](C(=O)N(C)Cc2cc(C)on2)[C@H]3C1=O,aldehyde
200946,Please add a benzene ring to the molecule C[C@@H]1CCC[C@@H]1NC(=O)C1(c2ccc(F)cc2F)CCOCC1.,C[C@@H]1CCC[C@@H]1NC(=O)C1(c2ccc(F)cc2F)CCOCC1,benzene ring
98613,Modify the molecule CCOCC(=O)N1CC[C@H](n2c(-c3ccco3)nc3cccnc32)C1 by adding a amine.,CCOCC(=O)N1CC[C@H](n2c(-c3ccco3)nc3cccnc32)C1,amine
198429,Please add a benzene ring to the molecule COc1ccc2[nH]cc(C3=CC[NH+](Cc4nc(CC(F)(F)F)no4)CC3)c2c1.,COc1ccc2[nH]cc(C3=CC[NH+](Cc4nc(CC(F)(F)F)no4)CC3)c2c1,benzene ring
10627,Add a amine to the molecule O=C(NCCn1cc[nH+]c1)[C@H]1CC=CCC1.,O=C(NCCn1cc[nH+]c1)[C@H]1CC=CCC1,amine
50935,Modify the molecule Cc1ccc2ncc(C(=O)N3CCCN(C(=O)C(C)(C)C)CC3)n2c1 by adding a nitrile.,Cc1ccc2ncc(C(=O)N3CCCN(C(=O)C(C)(C)C)CC3)n2c1,nitrile
167912,Modify the molecule O=C(c1cc(-c2ccccc2)n[nH]1)N(Cc1ccccn1)C[C@H]1CCCO1 by adding a amide.,O=C(c1cc(-c2ccccc2)n[nH]1)N(Cc1ccccn1)C[C@H]1CCCO1,amide
150059,Add a benzene ring to the molecule CCCc1nnc(Cn2nc(-c3ccco3)oc2=O)s1.,CCCc1nnc(Cn2nc(-c3ccco3)oc2=O)s1,benzene ring
226747,Please add a aldehyde to the molecule Cc1nc(C2CCN(S(=O)(=O)N(C)C)CC2)nc2c1CC(=O)N2CCc1ccccc1.,Cc1nc(C2CCN(S(=O)(=O)N(C)C)CC2)nc2c1CC(=O)N2CCc1ccccc1,aldehyde
144049,Modify the molecule O=S(=O)(NCc1cccnc1-n1cccn1)c1cccs1 by adding a amide.,O=S(=O)(NCc1cccnc1-n1cccn1)c1cccs1,amide
136490,Please add a hydroxyl to the molecule COCC1CCN(c2ccc(C#N)cn2)CC1.,COCC1CCN(c2ccc(C#N)cn2)CC1,hydroxyl
162700,Please add a benzene ring to the molecule C[C@@](O)(c1ccc(Cl)cc1)[C@H]1CCC[C@H](S(C)(=O)=O)C1.,C[C@@](O)(c1ccc(Cl)cc1)[C@H]1CCC[C@H](S(C)(=O)=O)C1,benzene ring
185936,Add a halo to the molecule O=C1CN(Cc2[nH][nH]c(=O)[nH+]2)[C@@H]2CCCC[C@H]2N1.,O=C1CN(Cc2[nH][nH]c(=O)[nH+]2)[C@@H]2CCCC[C@H]2N1,halo
72406,Please add a amide to the molecule COc1cccc2c1OCCCN(C(=O)c1cn3c(n1)C[NH2+]CC3)C2.,COc1cccc2c1OCCCN(C(=O)c1cn3c(n1)C[NH2+]CC3)C2,amide
178140,Add a halo to the molecule Cc1cc(C(=O)N2CCC(c3nnc(Cn4cccn4)n3C)CC2)cs1.,Cc1cc(C(=O)N2CCC(c3nnc(Cn4cccn4)n3C)CC2)cs1,halo
66726,Add a benzene ring to the molecule CCOc1ccc([C@H]2c3c(oc4cc(OC)ccc4c3=O)C(=O)N2CC[NH+](C)C)cc1.,CCOc1ccc([C@H]2c3c(oc4cc(OC)ccc4c3=O)C(=O)N2CC[NH+](C)C)cc1,benzene ring
24739,Modify the molecule CN1CCN(C(=O)[C@H](N)c2ccccc2)C(C)(C)C1=O by adding a benzene ring.,CN1CCN(C(=O)[C@H](N)c2ccccc2)C(C)(C)C1=O,benzene ring
213469,Modify the molecule CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(Cl)cc(Cl)c3)n2)cc1 by adding a amide.,CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(Cl)cc(Cl)c3)n2)cc1,amide
59264,Modify the molecule CC[NH2+][C@@H]([C@@H]1CCOC2(CCCC2)C1)[C@]1(C)CCCO1 by adding a thiol.,CC[NH2+][C@@H]([C@@H]1CCOC2(CCCC2)C1)[C@]1(C)CCCO1,thiol
191622,Please add a hydroxyl to the molecule C[C@H]1CCC[C@](C[NH3+])(C[C@@H]2CCCN(S(C)(=O)=O)C2)C1.,C[C@H]1CCC[C@](C[NH3+])(C[C@@H]2CCCN(S(C)(=O)=O)C2)C1,hydroxyl
42868,Please add a benzene ring to the molecule O=C(Oc1ccc(-n2ccnn2)cc1)C1CC=CC1.,O=C(Oc1ccc(-n2ccnn2)cc1)C1CC=CC1,benzene ring
136147,Modify the molecule Cc1cc(F)cc(N[C@@H](C(N)=O)C2CCC(C)CC2)c1 by adding a nitro.,Cc1cc(F)cc(N[C@@H](C(N)=O)C2CCC(C)CC2)c1,nitro
179028,Add a hydroxyl to the molecule CCCCc1ccc([C@H](O)C(F)(F)C(F)F)cc1.,CCCCc1ccc([C@H](O)C(F)(F)C(F)F)cc1,hydroxyl
108235,Add a hydroxyl to the molecule C=CCSc1nnc(-c2ccc(NC(=O)c3ccccc3OC)cc2)n1C.,C=CCSc1nnc(-c2ccc(NC(=O)c3ccccc3OC)cc2)n1C,hydroxyl
130136,Please add a benzene ring to the molecule Cc1cc(C)c2nc(C3CC3)cc(C(=O)NCCCc3nc(C)no3)c2c1.,Cc1cc(C)c2nc(C3CC3)cc(C(=O)NCCCc3nc(C)no3)c2c1,benzene ring
193391,Please add a benzene ring to the molecule CN(C(=O)OC(C)(C)C)[C@@H]1CCN(C(=O)Cc2cccc(F)c2F)C1.,CN(C(=O)OC(C)(C)C)[C@@H]1CCN(C(=O)Cc2cccc(F)c2F)C1,benzene ring
163684,Please add a amide to the molecule O=C(Nc1ccccc1OC[C@H]1CCCO1)N1CCc2n[nH]cc2C1.,O=C(Nc1ccccc1OC[C@H]1CCCO1)N1CCc2n[nH]cc2C1,amide
5347,Modify the molecule CCC[C@@H]1CN(C(=O)Nc2ccccc2N2C[C@H](C)O[C@H](C)C2)CCO1 by adding a hydroxyl.,CCC[C@@H]1CN(C(=O)Nc2ccccc2N2C[C@H](C)O[C@H](C)C2)CCO1,hydroxyl
137385,Modify the molecule COc1ccc([C@@H](CNC(=O)[C@H]2CC=CCC2)[NH+](C)C)cc1 by adding a halo.,COc1ccc([C@@H](CNC(=O)[C@H]2CC=CCC2)[NH+](C)C)cc1,halo
237500,Please add a nitro to the molecule O=C(Nc1ccc(Br)cn1)c1ccc(Cn2cnc([N+](=O)[O-])n2)cc1.,O=C(Nc1ccc(Br)cn1)c1ccc(Cn2cnc([N+](=O)[O-])n2)cc1,nitro
152157,Modify the molecule COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccc(C(=O)[O-])cc1 by adding a hydroxyl.,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccc(C(=O)[O-])cc1,hydroxyl
152034,Modify the molecule C#CCN(Cc1ccc(OC)cc1O)[C@@H]1CCS(=O)(=O)C1 by adding a benzene ring.,C#CCN(Cc1ccc(OC)cc1O)[C@@H]1CCS(=O)(=O)C1,benzene ring
41821,Modify the molecule Cc1ccc(-c2cc3cccnc3n2CCC(=O)[O-])cn1 by adding a hydroxyl.,Cc1ccc(-c2cc3cccnc3n2CCC(=O)[O-])cn1,hydroxyl
18104,Modify the molecule CCOc1cc(/C=C(/CO)C(C)C)cc(Cl)c1OC by adding a hydroxyl.,CCOc1cc(/C=C(/CO)C(C)C)cc(Cl)c1OC,hydroxyl
227043,Modify the molecule CN(C)c1ccc([N+](=O)[O-])cc1C(=O)NC[C@@H]1CN(C2CC2)CCO1 by adding a amide.,CN(C)c1ccc([N+](=O)[O-])cc1C(=O)NC[C@@H]1CN(C2CC2)CCO1,amide
86356,Add a amine to the molecule C[C@H]1CC[C@@H](C(C)(C)[C@@H]2CCO[C@]3(CCOC3)C2)[C@H](Br)C1.,C[C@H]1CC[C@@H](C(C)(C)[C@@H]2CCO[C@]3(CCOC3)C2)[C@H](Br)C1,amine
172686,Please add a nitro to the molecule Cn1cnc([N+](=O)[O-])c1Oc1ccc(C#N)cc1.,Cn1cnc([N+](=O)[O-])c1Oc1ccc(C#N)cc1,nitro
56692,Add a benzene ring to the molecule CNC(=O)C1CC[NH+]([C@@H](C)C(=O)N[C@@H](C)c2ccccc2C)CC1.,CNC(=O)C1CC[NH+]([C@@H](C)C(=O)N[C@@H](C)c2ccccc2C)CC1,benzene ring
14252,Please add a amide to the molecule CC1CC[NH+](CC(=O)Nc2ccc3c(c2)COC3)CC1.,CC1CC[NH+](CC(=O)Nc2ccc3c(c2)COC3)CC1,amide
76017,Add a benzene ring to the molecule C[NH2+][C@@H]1c2cc(OC)ccc2CC[C@H]1n1cncn1.,C[NH2+][C@@H]1c2cc(OC)ccc2CC[C@H]1n1cncn1,benzene ring
81381,Add a aldehyde to the molecule CC[C@@H](C)N(CC)C(=O)[C@@H]1C=C[C@@H]([NH3+])C1.,CC[C@@H](C)N(CC)C(=O)[C@@H]1C=C[C@@H]([NH3+])C1,aldehyde
206674,Please add a amide to the molecule CN(CCc1cccs1)c1cccc(Cl)c1C=O.,CN(CCc1cccs1)c1cccc(Cl)c1C=O,amide
91640,Modify the molecule CC(C)CC(=O)C1=C([O-])C(=O)N(CCc2ccccc2)[C@@H]1c1ccc(O)cc1 by adding a amide.,CC(C)CC(=O)C1=C([O-])C(=O)N(CCc2ccccc2)[C@@H]1c1ccc(O)cc1,amide
118336,Add a amide to the molecule Fc1ccc([C@H](CC(F)(F)F)NCc2ccc3c(c2)OCCO3)cc1.,Fc1ccc([C@H](CC(F)(F)F)NCc2ccc3c(c2)OCCO3)cc1,amide
20776,Add a nitro to the molecule Cc1ccc(CNC(=O)c2cccc(C#N)c2)cc1.,Cc1ccc(CNC(=O)c2cccc(C#N)c2)cc1,nitro
174228,Please add a nitrile to the molecule CN(C)C(=O)[C@@H]1CCCN1C(=O)C1=NN(c2ccc(F)cc2)[C@@H](C(N)=O)C1.,CN(C)C(=O)[C@@H]1CCCN1C(=O)C1=NN(c2ccc(F)cc2)[C@@H](C(N)=O)C1,nitrile
73218,Modify the molecule CCOC(=O)CCc1ccc(NC(=O)C2C[C@@H](C)O[C@H](C)C2)cc1 by adding a aldehyde.,CCOC(=O)CCc1ccc(NC(=O)C2C[C@@H](C)O[C@H](C)C2)cc1,aldehyde
24753,Modify the molecule CNC(=O)c1ccccc1NC(=O)c1ccc(SCc2cccnc2)cc1 by adding a benzene ring.,CNC(=O)c1ccccc1NC(=O)c1ccc(SCc2cccnc2)cc1,benzene ring
42464,Please add a hydroxyl to the molecule CC[C@@H](O)C[NH+]1CCC(NS(=O)(=O)c2cnc3c(c2)c(C)nn3C)CC1.,CC[C@@H](O)C[NH+]1CCC(NS(=O)(=O)c2cnc3c(c2)c(C)nn3C)CC1,hydroxyl
145457,Modify the molecule COc1cc(Cl)c(C)cc1NC(=O)CSC(=S)N(C)C by adding a hydroxyl.,COc1cc(Cl)c(C)cc1NC(=O)CSC(=S)N(C)C,hydroxyl
58124,Add a benzene ring to the molecule Cc1cccc(Oc2nc(C(F)(F)F)nc3ccccc23)c1.,Cc1cccc(Oc2nc(C(F)(F)F)nc3ccccc23)c1,benzene ring
165900,Add a carboxyl to the molecule CC(C)c1nnc(CCC(=O)N2CC=C(c3ccc(Cl)cc3)CC2)o1.,CC(C)c1nnc(CCC(=O)N2CC=C(c3ccc(Cl)cc3)CC2)o1,carboxyl
165116,Add a carboxyl to the molecule O=C(NCCC1=CCCCC1)N1CCC(n2cncn2)CC1.,O=C(NCCC1=CCCCC1)N1CCC(n2cncn2)CC1,carboxyl
188710,Add a hydroxyl to the molecule COc1cc(Cl)c(C)cc1NS(=O)(=O)c1ccccc1F.,COc1cc(Cl)c(C)cc1NS(=O)(=O)c1ccccc1F,hydroxyl
199059,Add a nitro to the molecule CCCCN(C(=O)N[C@H](C)Cc1cc(C)cc(C)c1)[C@H]1CCS(=O)(=O)C1.,CCCCN(C(=O)N[C@H](C)Cc1cc(C)cc(C)c1)[C@H]1CCS(=O)(=O)C1,nitro
231640,Add a carboxyl to the molecule Cc1cc(C)c(CNc2ncnc3[nH]ncc23)c(=O)[nH]1.,Cc1cc(C)c(CNc2ncnc3[nH]ncc23)c(=O)[nH]1,carboxyl
89615,Modify the molecule CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1 by adding a amide.,CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1,amide
241468,Please add a amide to the molecule CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O.,CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O,amide
9805,Add a aldehyde to the molecule CCNC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2cc(Br)ccc2F)C1.,CCNC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2cc(Br)ccc2F)C1,aldehyde
199771,Modify the molecule Cc1cccc(CCNC(=O)[C@H]2C=C3C(=O)[NH+]=c4ccccc4=C3S2)c1 by adding a amide.,Cc1cccc(CCNC(=O)[C@H]2C=C3C(=O)[NH+]=c4ccccc4=C3S2)c1,amide
119163,Add a benzene ring to the molecule COc1ccc(Nc2c(Cc3ccccc3)c(C)nc3ncnn23)c(OC)c1.,COc1ccc(Nc2c(Cc3ccccc3)c(C)nc3ncnn23)c(OC)c1,benzene ring
96887,Add a nitro to the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@@H](Sc2nccs2)C1.,C[NH2+][C@]1(C(=O)[O-])CCC[C@@H](Sc2nccs2)C1,nitro
17214,Add a benzene ring to the molecule CC(C)(C)Oc1cc(CNC(=O)c2ccc3nnnn3c2)ccn1.,CC(C)(C)Oc1cc(CNC(=O)c2ccc3nnnn3c2)ccn1,benzene ring
44895,Add a halo to the molecule C[C@H](NC(=O)NCCOC[C@H]1CCCO1)c1ccc(Cl)s1.,C[C@H](NC(=O)NCCOC[C@H]1CCCO1)c1ccc(Cl)s1,halo
236755,Modify the molecule CCOc1c(Cl)cc(CN[C@@H]2CC[C@@H]([NH+](C)C)C2)cc1OC by adding a nitro.,CCOc1c(Cl)cc(CN[C@@H]2CC[C@@H]([NH+](C)C)C2)cc1OC,nitro
205683,Please add a nitro to the molecule Cc1ccc(SCCNC(=O)N2CCC[C@@H](c3nc(C)no3)C2)cc1.,Cc1ccc(SCCNC(=O)N2CCC[C@@H](c3nc(C)no3)C2)cc1,nitro
134341,Modify the molecule Cc1cc(C)c2[nH]c(=O)c(CN(Cc3ccc(F)cc3)Cc3nnnn3C(C)(C)C)cc2c1 by adding a amine.,Cc1cc(C)c2[nH]c(=O)c(CN(Cc3ccc(F)cc3)Cc3nnnn3C(C)(C)C)cc2c1,amine
234088,Modify the molecule C[C@H]1CN([C@@H](C)c2nnnn2-c2ccccc2)C[C@@H](C)O1 by adding a hydroxyl.,C[C@H]1CN([C@@H](C)c2nnnn2-c2ccccc2)C[C@@H](C)O1,hydroxyl
58169,Please add a benzene ring to the molecule Cc1cccc([C@@](C)([NH3+])[C@H]2CCO[C@]3(CCSC3)C2)c1.,Cc1cccc([C@@](C)([NH3+])[C@H]2CCO[C@]3(CCSC3)C2)c1,benzene ring
68849,Modify the molecule Oc1ccc(Br)cc1/C=N/c1n[nH]c2ncccc12 by adding a carboxyl.,Oc1ccc(Br)cc1/C=N/c1n[nH]c2ncccc12,carboxyl
46260,Please add a hydroxyl to the molecule COc1ccc2c3c1O[C@H]1[C@@H](O)CC=C[C@@]31CC[N+](C)(C)C2.,COc1ccc2c3c1O[C@H]1[C@@H](O)CC=C[C@@]31CC[N+](C)(C)C2,hydroxyl
155473,Modify the molecule Cn1cc(C[NH+](C)CC2CCOCC2)c(-c2cccnc2)n1 by adding a benzene ring.,Cn1cc(C[NH+](C)CC2CCOCC2)c(-c2cccnc2)n1,benzene ring
49877,Modify the molecule CN(CC(=O)N1CCOC[C@@H]1C1CC1)C(=O)c1cccs1 by adding a amine.,CN(CC(=O)N1CCOC[C@@H]1C1CC1)C(=O)c1cccs1,amine
182171,Modify the molecule Cc1ccc([C@H]2CCCN2C(=O)N[C@H](CCCO)c2ccccc2)s1 by adding a benzene ring.,Cc1ccc([C@H]2CCCN2C(=O)N[C@H](CCCO)c2ccccc2)s1,benzene ring
166121,Please add a hydroxyl to the molecule Cc1cccc(NC(=O)[C@@H]2Cc3ccccc3S2)c1Cl.,Cc1cccc(NC(=O)[C@@H]2Cc3ccccc3S2)c1Cl,hydroxyl
124507,Add a nitrile to the molecule Cc1cc(C)c(C(=O)N[C@@H]2CC3(CCOCC3)Oc3ccccc32)c(=O)[nH]1.,Cc1cc(C)c(C(=O)N[C@@H]2CC3(CCOCC3)Oc3ccccc32)c(=O)[nH]1,nitrile
114521,Please add a amide to the molecule COC(=O)C1CCN(C(=O)[C@@H](C)[NH+](C)Cc2sccc2C)CC1.,COC(=O)C1CCN(C(=O)[C@@H](C)[NH+](C)Cc2sccc2C)CC1,amide
130587,Please add a hydroxyl to the molecule O=C(c1cc2c(s1)CCCCC2)N(Cc1cccnc1)C[C@H]1CCCO1.,O=C(c1cc2c(s1)CCCCC2)N(Cc1cccnc1)C[C@H]1CCCO1,hydroxyl
57365,Please add a carboxyl to the molecule COc1ccc(-c2nc3cc(C)ccc3n2C)cc1OCCCC#N.,COc1ccc(-c2nc3cc(C)ccc3n2C)cc1OCCCC#N,carboxyl
230463,Add a nitro to the molecule CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1.,CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1,nitro
4541,Add a halo to the molecule CC(C)C[C@@H](O)CNC(=O)Nc1ccccc1C(=O)N1C[C@H](C)C[C@@H](C)C1.,CC(C)C[C@@H](O)CNC(=O)Nc1ccccc1C(=O)N1C[C@H](C)C[C@@H](C)C1,halo
129616,Add a hydroxyl to the molecule CC[C@@H](C)[NH2+][C@H](CN=[N+]=[N-])C(=O)[O-].,CC[C@@H](C)[NH2+][C@H](CN=[N+]=[N-])C(=O)[O-],hydroxyl
20239,Add a carboxyl to the molecule O=C(Nc1cccnc1)[C@H]1CCCO1.,O=C(Nc1cccnc1)[C@H]1CCCO1,carboxyl
140395,Modify the molecule COc1cc(OC)c(C(=O)N[C@@H]2CC(C)(C)Cc3oc(C)cc32)cc1OC by adding a amide.,COc1cc(OC)c(C(=O)N[C@@H]2CC(C)(C)Cc3oc(C)cc32)cc1OC,amide
110726,Please add a hydroxyl to the molecule COc1ccc([C@@H]2C(C#N)=C(N)Oc3cc(OC(=O)c4cccc(Cl)c4)ccc32)cc1OC.,COc1ccc([C@@H]2C(C#N)=C(N)Oc3cc(OC(=O)c4cccc(Cl)c4)ccc32)cc1OC,hydroxyl
215854,Modify the molecule CNC(=O)[C@@H]1CCCN(c2ncc(C(F)(F)F)cc2Cl)C1 by adding a amine.,CNC(=O)[C@@H]1CCCN(c2ncc(C(F)(F)F)cc2Cl)C1,amine
237904,Add a hydroxyl to the molecule NC(=O)c1ccc(Cl)c(NC(=O)c2ccc(F)cc2I)c1.,NC(=O)c1ccc(Cl)c(NC(=O)c2ccc(F)cc2I)c1,hydroxyl
215715,Add a amide to the molecule CCOCCSc1ccc(N)cn1.,CCOCCSc1ccc(N)cn1,amide
90477,Add a amide to the molecule Cc1cc(NC(=O)CO[C@H]2CCC[C@@H](C)C2)n(Cc2ccccn2)n1.,Cc1cc(NC(=O)CO[C@H]2CCC[C@@H](C)C2)n(Cc2ccccn2)n1,amide
3736,Please add a aldehyde to the molecule Cc1cnn(CCCCC[NH+]2CCN(c3ccc(O)cc3)CC2)c1.,Cc1cnn(CCCCC[NH+]2CCN(c3ccc(O)cc3)CC2)c1,aldehyde
118559,Please add a amine to the molecule Cc1nc(N2CCOCC2)[nH]c(=O)c1CCC(=O)Nc1ccc2c(c1)CCC2.,Cc1nc(N2CCOCC2)[nH]c(=O)c1CCC(=O)Nc1ccc2c(c1)CCC2,amine
190948,Modify the molecule CCc1nc(NC(=O)CCc2cc(OC)ccc2OC)sc1C by adding a benzene ring.,CCc1nc(NC(=O)CCc2cc(OC)ccc2OC)sc1C,benzene ring
175778,Modify the molecule CNC(=O)c1ccc(NC(=O)N2CCC[C@H](c3nc(C)no3)C2)cc1 by adding a nitro.,CNC(=O)c1ccc(NC(=O)N2CCC[C@H](c3nc(C)no3)C2)cc1,nitro
239970,Modify the molecule Cc1cccc(OC[C@@H](C)NC(=O)c2ccc(C)[nH]c2=O)c1 by adding a carboxyl.,Cc1cccc(OC[C@@H](C)NC(=O)c2ccc(C)[nH]c2=O)c1,carboxyl
21282,Please add a amide to the molecule CCn1nc(C)c2c(C(F)(F)F)cc(-c3ccc(OC(F)F)cc3)nc21.,CCn1nc(C)c2c(C(F)(F)F)cc(-c3ccc(OC(F)F)cc3)nc21,amide
237404,Modify the molecule CCc1cnc(CNC(=O)N[C@H]2[C@H]3CCO[C@@H]3C23CCCC3)s1 by adding a halo.,CCc1cnc(CNC(=O)N[C@H]2[C@H]3CCO[C@@H]3C23CCCC3)s1,halo
85059,Add a benzene ring to the molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC3(C#N)CC3)cc2)cc1.,CC(=O)c1ccc(Oc2ccc(C(=O)NC3(C#N)CC3)cc2)cc1,benzene ring
169428,Modify the molecule CC[C@@H]1CCC[C@](O)(Cc2[nH+]c3ccccc3n2C)CC1 by adding a amide.,CC[C@@H]1CCC[C@](O)(Cc2[nH+]c3ccccc3n2C)CC1,amide
4687,Add a benzene ring to the molecule Cc1cnc2c(c1)[nH]c(=S)n2CC(C)(C)S(C)(=O)=O.,Cc1cnc2c(c1)[nH]c(=S)n2CC(C)(C)S(C)(=O)=O,benzene ring
133781,Please add a benzene ring to the molecule CNC(=O)[C@H]1CCCC[C@@H]1[NH2+][C@@H](C)CCc1ccc(OC)cc1.,CNC(=O)[C@H]1CCCC[C@@H]1[NH2+][C@@H](C)CCc1ccc(OC)cc1,benzene ring
167998,Modify the molecule Cc1n[nH]c(C(=O)Nc2ccc(N(C)C)cc2)n1 by adding a halo.,Cc1n[nH]c(C(=O)Nc2ccc(N(C)C)cc2)n1,halo
43598,Please add a benzene ring to the molecule Oc1ccccc1NC[C@@H](O)Cn1ccc2ccccc21.,Oc1ccccc1NC[C@@H](O)Cn1ccc2ccccc21,benzene ring
123188,Please add a amide to the molecule C[C@H](C#N)C[NH2+][C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)C1.,C[C@H](C#N)C[NH2+][C@@H]1CCC[C@H](NC(=O)OC(C)(C)C)C1,amide
111486,Please add a amine to the molecule CC1=NN(C(=O)c2ccc(-c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1.,CC1=NN(C(=O)c2ccc(-c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1,amine
45835,Add a halo to the molecule NS(=O)(=O)C[C@@H]1CCCN(C(=O)c2cc3cccc(Cl)c3o2)C1.,NS(=O)(=O)C[C@@H]1CCCN(C(=O)c2cc3cccc(Cl)c3o2)C1,halo
236024,Modify the molecule COc1ccccc1[C@@H](C#N)NC(=O)c1cc(C(C)C)no1 by adding a carboxyl.,COc1ccccc1[C@@H](C#N)NC(=O)c1cc(C(C)C)no1,carboxyl
196479,Add a aldehyde to the molecule C[C@@H](CCN1CCOCC1)[NH2+][C@H](C)c1cccc(N2CCOC2=O)c1.,C[C@@H](CCN1CCOCC1)[NH2+][C@H](C)c1cccc(N2CCOC2=O)c1,aldehyde
219315,Please add a halo to the molecule O=C(NC1(c2nc(-c3cnccn3)no2)CCCCC1)c1cc2cc(Cl)ccc2[nH]1.,O=C(NC1(c2nc(-c3cnccn3)no2)CCCCC1)c1cc2cc(Cl)ccc2[nH]1,halo
66129,Please add a halo to the molecule CCC[C@H]1CN(C(=O)c2nc(-c3ccccc3)[nH]c2C)C[C@@H]1[NH3+].,CCC[C@H]1CN(C(=O)c2nc(-c3ccccc3)[nH]c2C)C[C@@H]1[NH3+],halo
38911,Please add a carboxyl to the molecule COc1ccc(F)cc1NC(=O)N1CCC[C@@H](C)[C@@H]1CO.,COc1ccc(F)cc1NC(=O)N1CCC[C@@H](C)[C@@H]1CO,carboxyl
32184,Modify the molecule C[C@@H]1CCCN(S(=O)(=O)c2ccc(C(=O)Nc3nnc(-c4ccc(C(F)(F)F)cc4)o3)cc2)C1 by adding a carboxyl.,C[C@@H]1CCCN(S(=O)(=O)c2ccc(C(=O)Nc3nnc(-c4ccc(C(F)(F)F)cc4)o3)cc2)C1,carboxyl
196920,Modify the molecule Cc1nc2ccccc2c(=O)n1/N=C\c1ccc(F)cc1 by adding a nitro.,Cc1nc2ccccc2c(=O)n1/N=C\c1ccc(F)cc1,nitro
164824,Please add a halo to the molecule C[C@H](Sc1nnc(-c2ccc(Cl)cc2)o1)C(=O)NC1CC1.,C[C@H](Sc1nnc(-c2ccc(Cl)cc2)o1)C(=O)NC1CC1,halo
193531,Please add a amide to the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1,amide
19705,Please add a amide to the molecule C[NH+](C)CCNc1ccc(C#N)c(N)c1.,C[NH+](C)CCNc1ccc(C#N)c(N)c1,amide
64929,Add a benzene ring to the molecule CCOC(=O)N1CCC([NH2+]C[C@@H](C)c2nc(-c3ccccc3)no2)CC1.,CCOC(=O)N1CCC([NH2+]C[C@@H](C)c2nc(-c3ccccc3)no2)CC1,benzene ring
203189,Modify the molecule CCNC(=O)NC(=O)[C@@H](C)Sc1nnc(-c2ccccc2)n1-c1ccccc1 by adding a amide.,CCNC(=O)NC(=O)[C@@H](C)Sc1nnc(-c2ccccc2)n1-c1ccccc1,amide
149901,Modify the molecule CCSCc1ccnc(NC2CCN(C(=O)CC)CC2)c1 by adding a aldehyde.,CCSCc1ccnc(NC2CCN(C(=O)CC)CC2)c1,aldehyde
100946,Add a hydroxyl to the molecule CC(C)c1nc2cc(NC(=O)CN3CCS(=O)(=O)CC3)ccc2o1.,CC(C)c1nc2cc(NC(=O)CN3CCS(=O)(=O)CC3)ccc2o1,hydroxyl
224839,Please add a halo to the molecule O=C(N[C@H]1CC[C@@H]2CCC[C@@H]21)c1ncc(F)cc1F.,O=C(N[C@H]1CC[C@@H]2CCC[C@@H]21)c1ncc(F)cc1F,halo
53769,Modify the molecule C[C@H]1Cc2cc(-c3cc(CNC(=O)CCn4cnc5ccccc5c4=O)no3)ccc2O1 by adding a hydroxyl.,C[C@H]1Cc2cc(-c3cc(CNC(=O)CCn4cnc5ccccc5c4=O)no3)ccc2O1,hydroxyl
25513,Modify the molecule CCC[C@@H](CS)C[NH+](C)Cc1ccncc1 by adding a nitrile.,CCC[C@@H](CS)C[NH+](C)Cc1ccncc1,nitrile
188159,Please add a amine to the molecule C#CCN1C(=O)S/C(=C/c2ccccc2OCc2ccc(C)cc2)C1=O.,C#CCN1C(=O)S/C(=C/c2ccccc2OCc2ccc(C)cc2)C1=O,amine
113565,Add a hydroxyl to the molecule C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1.,C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1,hydroxyl
200480,Add a nitro to the molecule COc1ncnc(N)c1CN1CCO[C@H](c2ccc(Br)cc2)[C@@H]1C.,COc1ncnc(N)c1CN1CCO[C@H](c2ccc(Br)cc2)[C@@H]1C,nitro
134198,Add a hydroxyl to the molecule CC(=O)NC[C@H]1CCCN(C(=O)Nc2ccc(N(C)C(C)C)c(F)c2)C1.,CC(=O)NC[C@H]1CCCN(C(=O)Nc2ccc(N(C)C(C)C)c(F)c2)C1,hydroxyl
168048,Modify the molecule CC(C)[C@@H](NC(=O)CS[C@@H]1N=NNN1c1ccccc1Cl)C1[NH+]=c2ccccc2=[NH+]1 by adding a carboxyl.,CC(C)[C@@H](NC(=O)CS[C@@H]1N=NNN1c1ccccc1Cl)C1[NH+]=c2ccccc2=[NH+]1,carboxyl
147503,Add a amide to the molecule CCc1ccccc1NC(=O)C1CCN(C(=O)[C@@H]2CC(=O)N(c3ccccc3)C2)CC1.,CCc1ccccc1NC(=O)C1CCN(C(=O)[C@@H]2CC(=O)N(c3ccccc3)C2)CC1,amide
227480,Please add a amide to the molecule Cc1nn(C)c(=O)c(C(=O)N2C[C@@H](O)C[C@H]2c2cc(F)ccc2F)c1C.,Cc1nn(C)c(=O)c(C(=O)N2C[C@@H](O)C[C@H]2c2cc(F)ccc2F)c1C,amide
36493,Add a benzene ring to the molecule CC[NH+]1CCN(c2cc(CNc3cccc(C(=O)OC)n3)cc[nH+]2)CC1.,CC[NH+]1CCN(c2cc(CNc3cccc(C(=O)OC)n3)cc[nH+]2)CC1,benzene ring
104980,Modify the molecule CCc1nnc([C@@H](C)N2CCN(c3ccc(C#N)cc3F)CC2)o1 by adding a hydroxyl.,CCc1nnc([C@@H](C)N2CCN(c3ccc(C#N)cc3F)CC2)o1,hydroxyl
203946,Please add a halo to the molecule CN(C)[C@@H](C(=O)N1CC(c2cccnc2)C1)c1ccccc1F.,CN(C)[C@@H](C(=O)N1CC(c2cccnc2)C1)c1ccccc1F,halo
11055,Add a nitrile to the molecule Cc1cc(C(=O)N2CCN(CC(C)(C)C[NH+](C)Cc3ccccc3)CC2)on1.,Cc1cc(C(=O)N2CCN(CC(C)(C)C[NH+](C)Cc3ccccc3)CC2)on1,nitrile
32918,Please add a nitrile to the molecule CCCCNC(=O)Cc1noc(CN2CCc3c([nH+]cn3C)C2)n1.,CCCCNC(=O)Cc1noc(CN2CCc3c([nH+]cn3C)C2)n1,nitrile
26042,Add a aldehyde to the molecule CCC(=O)N1CCN(C(=O)NCc2ccc3c(c2)CCCN3C)CC1.,CCC(=O)N1CCN(C(=O)NCc2ccc3c(c2)CCCN3C)CC1,aldehyde
15343,Add a amide to the molecule Cc1ccc([C@H](C)N2CC[NH2+]C[C@@H]2C(=O)N(C)C)cc1F.,Cc1ccc([C@H](C)N2CC[NH2+]C[C@@H]2C(=O)N(C)C)cc1F,amide
169268,Modify the molecule Cc1nc2nc(N3CCCC3)nn2c(Cl)c1C by adding a benzene ring.,Cc1nc2nc(N3CCCC3)nn2c(Cl)c1C,benzene ring
179518,Add a carboxyl to the molecule Cn1ncnc1CCNC(=O)N[C@H]1CCCC[C@@H]1C(C)(C)C.,Cn1ncnc1CCNC(=O)N[C@H]1CCCC[C@@H]1C(C)(C)C,carboxyl
225545,Add a carboxyl to the molecule O=C(Nc1ccccc1)Nc1nnc(COc2ccc(Br)cc2Br)s1.,O=C(Nc1ccccc1)Nc1nnc(COc2ccc(Br)cc2Br)s1,carboxyl
107277,Add a amide to the molecule COc1c(C)c[nH+]c(CN(C)c2c(C)noc2C)c1C.,COc1c(C)c[nH+]c(CN(C)c2c(C)noc2C)c1C,amide
45056,Add a amine to the molecule COC(=O)C1=C(C)NC2=C(C(=O)C[C@H](c3ccccc3OC)C2)[C@@H]1c1ccc(OC(C)=O)cc1.,COC(=O)C1=C(C)NC2=C(C(=O)C[C@H](c3ccccc3OC)C2)[C@@H]1c1ccc(OC(C)=O)cc1,amine
207764,Modify the molecule CCc1ccc(NC(=O)c2ccc3c(c2)NC(=O)[C@H](C)S3)cc1 by adding a hydroxyl.,CCc1ccc(NC(=O)c2ccc3c(c2)NC(=O)[C@H](C)S3)cc1,hydroxyl
210504,Add a amine to the molecule O=S(=O)(Nc1cnn(Cc2ccccc2F)c1)c1ccc(Cl)cc1.,O=S(=O)(Nc1cnn(Cc2ccccc2F)c1)c1ccc(Cl)cc1,amine
2372,Modify the molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@@]1=O by adding a benzene ring.,CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@@]1=O,benzene ring
104848,Add a benzene ring to the molecule Cc1cnc(C(C)(C)NC(=O)CCc2c(C)noc2C)s1.,Cc1cnc(C(C)(C)NC(=O)CCc2c(C)noc2C)s1,benzene ring
152818,Modify the molecule COc1ccccc1CNC(=O)Cc1c(C)noc1C by adding a benzene ring.,COc1ccccc1CNC(=O)Cc1c(C)noc1C,benzene ring
32236,Please add a amine to the molecule Cc1c(Cl)cccc1NC(=O)[C@]1(C)Oc2ccccc2NC1=O.,Cc1c(Cl)cccc1NC(=O)[C@]1(C)Oc2ccccc2NC1=O,amine
148420,Add a nitrile to the molecule COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1.,COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1,nitrile
196229,Please add a hydroxyl to the molecule COC[C@H](C)N1CCN(C(=O)c2cnc(-c3ccsc3)s2)CC1.,COC[C@H](C)N1CCN(C(=O)c2cnc(-c3ccsc3)s2)CC1,hydroxyl
148296,Modify the molecule C=CCNC(=O)NC(=O)Cn1nnc(-c2cccc(C(F)(F)F)c2)n1 by adding a amide.,C=CCNC(=O)NC(=O)Cn1nnc(-c2cccc(C(F)(F)F)c2)n1,amide
81410,Add a benzene ring to the molecule CC(C)(C)[C@@]1(CCCc2ccccc2)CCC[NH2+]1.,CC(C)(C)[C@@]1(CCCc2ccccc2)CCC[NH2+]1,benzene ring
72459,Modify the molecule C[C@H](NC(=O)[C@@H](C)[NH+]1CCNC(=O)C1)c1ccccc1 by adding a benzene ring.,C[C@H](NC(=O)[C@@H](C)[NH+]1CCNC(=O)C1)c1ccccc1,benzene ring
100168,Add a benzene ring to the molecule O=S(=O)(C(N=C(Cl)Cl)=C(Cl)Cl)c1ccccc1.,O=S(=O)(C(N=C(Cl)Cl)=C(Cl)Cl)c1ccccc1,benzene ring
119519,Please add a amide to the molecule O=C(Cc1cc(-c2ccc(F)cc2)on1)Nc1ccc(Br)cc1F.,O=C(Cc1cc(-c2ccc(F)cc2)on1)Nc1ccc(Br)cc1F,amide
7954,Add a amide to the molecule CCOC(=O)[C@H](F)[C@](C)(O)c1ccc(S(C)(=O)=O)cc1.,CCOC(=O)[C@H](F)[C@](C)(O)c1ccc(S(C)(=O)=O)cc1,amide
50205,Add a hydroxyl to the molecule O=C(Cn1nc2n(c1=O)-c1ccccc1SC2)N/N=C/c1cccs1.,O=C(Cn1nc2n(c1=O)-c1ccccc1SC2)N/N=C/c1cccs1,hydroxyl
233630,Add a amine to the molecule CCC(CC)([C@@H](Cc1ccc(O)cc1)NC)[NH+](C)C.,CCC(CC)([C@@H](Cc1ccc(O)cc1)NC)[NH+](C)C,amine
95229,Add a hydroxyl to the molecule C[C@@H](NC=C1C(=O)N(C)C(=O)N(C)C1=O)c1ccccc1Cl.,C[C@@H](NC=C1C(=O)N(C)C(=O)N(C)C1=O)c1ccccc1Cl,hydroxyl
105941,Modify the molecule Cc1ccc(O)c2c1[C@@H]1C=CC[C@@H]1[C@H](c1cc([N+](=O)[O-])ccc1O)N2 by adding a benzene ring.,Cc1ccc(O)c2c1[C@@H]1C=CC[C@@H]1[C@H](c1cc([N+](=O)[O-])ccc1O)N2,benzene ring
241296,Add a hydroxyl to the molecule O=C(NCC1(O)CCSCC1)[C@H]1C[C@@H]1c1cccc(F)c1.,O=C(NCC1(O)CCSCC1)[C@H]1C[C@@H]1c1cccc(F)c1,hydroxyl
214871,Add a hydroxyl to the molecule CC[NH2+][C@@H](c1cccc2cnccc12)[C@@H]1CSCCS1.,CC[NH2+][C@@H](c1cccc2cnccc12)[C@@H]1CSCCS1,hydroxyl
29853,Add a benzene ring to the molecule Cn1cc(-c2nc(C(=O)OCc3ccc(C#N)cc3)cs2)cn1.,Cn1cc(-c2nc(C(=O)OCc3ccc(C#N)cc3)cs2)cn1,benzene ring
234238,Add a hydroxyl to the molecule COc1ncnc(SC2CCCCC2)c1N.,COc1ncnc(SC2CCCCC2)c1N,hydroxyl
143151,Modify the molecule CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1 by adding a nitro.,CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1,nitro
74774,Add a nitro to the molecule CCOc1ncnc(Nc2ccc(Br)cc2C)c1N.,CCOc1ncnc(Nc2ccc(Br)cc2C)c1N,nitro
75250,Add a amide to the molecule CCCN(CC(F)(F)F)[C@@H]1CCc2cc(N)ccc21.,CCCN(CC(F)(F)F)[C@@H]1CCc2cc(N)ccc21,amide
243126,Add a hydroxyl to the molecule Cc1ccc(-n2cnnc2SCC(=O)Nc2ncc(Cl)c(C)c2Cl)cc1Cl.,Cc1ccc(-n2cnnc2SCC(=O)Nc2ncc(Cl)c(C)c2Cl)cc1Cl,hydroxyl
139986,Add a carboxyl to the molecule C[C@@H](c1ccncc1)N(C)C(=O)NC[C@@H](C)C[NH+]1CCN(C)CC1.,C[C@@H](c1ccncc1)N(C)C(=O)NC[C@@H](C)C[NH+]1CCN(C)CC1,carboxyl
32604,Add a benzene ring to the molecule CC(C)c1ccc(S(=O)(=O)NC[C@]2(O)CCOc3ccccc32)cc1.,CC(C)c1ccc(S(=O)(=O)NC[C@]2(O)CCOc3ccccc32)cc1,benzene ring
176968,Modify the molecule Cc1ccccc1O[C@H](C)CNC(=O)[C@@H]1CCC[NH+](C)C1 by adding a halo.,Cc1ccccc1O[C@H](C)CNC(=O)[C@@H]1CCC[NH+](C)C1,halo
168709,Add a aldehyde to the molecule CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1.,CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1,aldehyde
27709,Please add a benzene ring to the molecule O=C(Nc1cccc(C[NH+]2CCN(C3CC3)C(=O)C2)c1)c1ccc(Cl)cc1.,O=C(Nc1cccc(C[NH+]2CCN(C3CC3)C(=O)C2)c1)c1ccc(Cl)cc1,benzene ring
31300,Please add a amide to the molecule CCN(CC)C(=O)c1ccccc1NC(=O)C(=O)N[C@H](C)c1ccccc1C.,CCN(CC)C(=O)c1ccccc1NC(=O)C(=O)N[C@H](C)c1ccccc1C,amide
17114,Modify the molecule Cc1nnc(NCCNC(=O)OC(C)(C)C)c(C#N)c1C by adding a hydroxyl.,Cc1nnc(NCCNC(=O)OC(C)(C)C)c(C#N)c1C,hydroxyl
171548,Modify the molecule COc1ccccc1N1C[C@H](C(=O)OC[C@@H]2CC=CC[C@H]2C)CC1=O by adding a hydroxyl.,COc1ccccc1N1C[C@H](C(=O)OC[C@@H]2CC=CC[C@H]2C)CC1=O,hydroxyl
202076,Add a benzene ring to the molecule COc1cc(C(=O)N(CC2=C[C@H]3N=CC=C3C=C2)C2CC2)cc(OC)c1OC.,COc1cc(C(=O)N(CC2=C[C@H]3N=CC=C3C=C2)C2CC2)cc(OC)c1OC,benzene ring
102482,Please add a nitro to the molecule COC(=O)C(C)(C)[C@@H]1CCCN(C(=O)c2ccc(C)c(C)c2)C1.,COC(=O)C(C)(C)[C@@H]1CCCN(C(=O)c2ccc(C)c(C)c2)C1,nitro
221230,Add a hydroxyl to the molecule Cn1c(=O)c2ccccc2n2c(CN3CCO[C@@H](c4cccc(F)c4)C3)nnc12.,Cn1c(=O)c2ccccc2n2c(CN3CCO[C@@H](c4cccc(F)c4)C3)nnc12,hydroxyl
229375,Please add a halo to the molecule CC(=O)Nc1cc(C(=O)N(C)[C@@H]2CCCC[C@@H]2S(C)(=O)=O)ccc1F.,CC(=O)Nc1cc(C(=O)N(C)[C@@H]2CCCC[C@@H]2S(C)(=O)=O)ccc1F,halo
162420,Modify the molecule COc1ccc(F)c(NC(=O)C(=O)NCc2cc(C#N)ccc2F)c1 by adding a benzene ring.,COc1ccc(F)c(NC(=O)C(=O)NCc2cc(C#N)ccc2F)c1,benzene ring
1700,Add a carboxyl to the molecule Cc1ccccc1[C@@H](C)NC(=O)c1cc(-c2ccncc2)nc2ccccc12.,Cc1ccccc1[C@@H](C)NC(=O)c1cc(-c2ccncc2)nc2ccccc12,carboxyl
227564,Add a amide to the molecule CC(C)[C@H](NC(=O)/C(=C\c1ccc(Cl)cc1)NC(=O)c1ccco1)C(=O)[O-].,CC(C)[C@H](NC(=O)/C(=C\c1ccc(Cl)cc1)NC(=O)c1ccco1)C(=O)[O-],amide
39835,Add a hydroxyl to the molecule Cc1nn(C(=O)[C@H]2CCCN2S(=O)(=O)c2ccccc2)c(C)c1Sc1ccccc1.,Cc1nn(C(=O)[C@H]2CCCN2S(=O)(=O)c2ccccc2)c(C)c1Sc1ccccc1,hydroxyl
137323,Please add a carboxyl to the molecule Cc1nn(-c2ccccn2)c2c1C(=O)[C@@H](Br)C(C)(C)C2.,Cc1nn(-c2ccccn2)c2c1C(=O)[C@@H](Br)C(C)(C)C2,carboxyl
112808,Modify the molecule CCCN(C(=O)c1ccc2c(c1)C(=O)N(C)C2=O)[C@@H]1CCc2ccccc2C1 by adding a amine.,CCCN(C(=O)c1ccc2c(c1)C(=O)N(C)C2=O)[C@@H]1CCc2ccccc2C1,amine
144402,Please add a carboxyl to the molecule C[C@H]1CCCCN1C(=O)Cn1c(CNC(=O)c2cccc(Br)c2)nc2ccccc21.,C[C@H]1CCCCN1C(=O)Cn1c(CNC(=O)c2cccc(Br)c2)nc2ccccc21,carboxyl
93831,Add a aldehyde to the molecule C[C@@H](Cc1cccc(F)c1)NC(=O)N1C[C@H]2CCCC[C@H]2C1.,C[C@@H](Cc1cccc(F)c1)NC(=O)N1C[C@H]2CCCC[C@H]2C1,aldehyde
213435,Add a benzene ring to the molecule C[C@H]1OCCN(Cc2ccc(OC[C@@H]3CCCO3)cc2)[C@@H]1C.,C[C@H]1OCCN(Cc2ccc(OC[C@@H]3CCCO3)cc2)[C@@H]1C,benzene ring
34725,Please add a carboxyl to the molecule CN1C(=O)C(C)(C)Oc2ccc([C@@H](O)c3ccco3)cc21.,CN1C(=O)C(C)(C)Oc2ccc([C@@H](O)c3ccco3)cc21,carboxyl
145264,Please add a hydroxyl to the molecule c1ccc2c(c1)O[C@H](c1ccsc1)N1N=C(c3ccc4c(c3)OCO4)C[C@@H]21.,c1ccc2c(c1)O[C@H](c1ccsc1)N1N=C(c3ccc4c(c3)OCO4)C[C@@H]21,hydroxyl
116504,Modify the molecule Cc1ccc2cccc(Oc3ncnc(NN(c4ccccc4)c4ccccc4)c3N)c2n1 by adding a amide.,Cc1ccc2cccc(Oc3ncnc(NN(c4ccccc4)c4ccccc4)c3N)c2n1,amide
154012,Please add a hydroxyl to the molecule CC(C)Cn1ccnc(NC[C@@H](C)Nc2ccccc2)c1=O.,CC(C)Cn1ccnc(NC[C@@H](C)Nc2ccccc2)c1=O,hydroxyl
39006,Add a halo to the molecule O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1.,O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1,halo
241259,Add a carboxyl to the molecule C[NH2+]C[C@H]1CCCCN1c1nc(Br)cs1.,C[NH2+]C[C@H]1CCCCN1c1nc(Br)cs1,carboxyl
240493,Add a nitro to the molecule CC(C)=C[C@@H]1[C@@H](C(=O)Nc2ccc(OCC(N)=O)cc2)C1(C)C.,CC(C)=C[C@@H]1[C@@H](C(=O)Nc2ccc(OCC(N)=O)cc2)C1(C)C,nitro
232068,Add a benzene ring to the molecule O=C(c1cccc(Cl)c1)N1CCN(c2nc(C3CC3)no2)CC1.,O=C(c1cccc(Cl)c1)N1CCN(c2nc(C3CC3)no2)CC1,benzene ring
247988,Please add a hydroxyl to the molecule O=C(CN1CCN(C(=O)C2CC2)CC1)Nc1ccccc1C(=O)Nc1ccc(F)cc1.,O=C(CN1CCN(C(=O)C2CC2)CC1)Nc1ccccc1C(=O)Nc1ccc(F)cc1,hydroxyl
1278,Add a halo to the molecule Clc1ccc(C2([NH2+]C3CCCC3)CCOCC2)cc1.,Clc1ccc(C2([NH2+]C3CCCC3)CCOCC2)cc1,halo
194114,Please add a halo to the molecule C[C@@H]1C[NH+](C2CC[NH+](Cc3ccccc3Cl)CC2)C[C@@H](C)O1.,C[C@@H]1C[NH+](C2CC[NH+](Cc3ccccc3Cl)CC2)C[C@@H](C)O1,halo
246511,Add a halo to the molecule Cc1ccc(C(=O)Nc2nc[nH]n2)cc1F.,Cc1ccc(C(=O)Nc2nc[nH]n2)cc1F,halo
186275,Modify the molecule CC(C)(C(=O)[O-])c1ccc([N-]S(=O)(=O)c2c(F)cc(F)cc2F)cc1 by adding a nitro.,CC(C)(C(=O)[O-])c1ccc([N-]S(=O)(=O)c2c(F)cc(F)cc2F)cc1,nitro
204887,Please add a halo to the molecule CC[C@@]1(C)CCC[NH+](CCC(=O)Nc2ccccc2[N+](=O)[O-])C1.,CC[C@@]1(C)CCC[NH+](CCC(=O)Nc2ccccc2[N+](=O)[O-])C1,halo
232712,Add a hydroxyl to the molecule COc1ccc(C[NH+]2CCC(NC(=O)N(C)C3CCOCC3)CC2)cc1F.,COc1ccc(C[NH+]2CCC(NC(=O)N(C)C3CCOCC3)CC2)cc1F,hydroxyl
79082,Please add a amide to the molecule Cc1n[nH]c(-c2ccc(NS(=O)(=O)c3cccc(F)c3)cc2)n1.,Cc1n[nH]c(-c2ccc(NS(=O)(=O)c3cccc(F)c3)cc2)n1,amide
75351,Modify the molecule O=C(CCCNC(=O)c1ccco1)Nc1cc(-c2ccco2)ccc1F by adding a halo.,O=C(CCCNC(=O)c1ccco1)Nc1cc(-c2ccco2)ccc1F,halo
72860,Add a aldehyde to the molecule Cc1ccc(C(C)C)cc1O[C@H](C)C(=O)NC[C@@H]1CCCO1.,Cc1ccc(C(C)C)cc1O[C@H](C)C(=O)NC[C@@H]1CCCO1,aldehyde
244814,Please add a hydroxyl to the molecule [NH3+]CCCCSc1cc2ccccc2[nH]1.,[NH3+]CCCCSc1cc2ccccc2[nH]1,hydroxyl
155599,Add a hydroxyl to the molecule Cc1ccc(CN(C)Cc2ncnn2C)cc1C.,Cc1ccc(CN(C)Cc2ncnn2C)cc1C,hydroxyl
5262,Add a benzene ring to the molecule CC[C@H]1CCCCN1C(=O)Cn1cccc1-c1nc(-c2cccc(Cl)c2)no1.,CC[C@H]1CCCCN1C(=O)Cn1cccc1-c1nc(-c2cccc(Cl)c2)no1,benzene ring
143707,Please add a benzene ring to the molecule CN(C)c1ccc(C(=O)NCCS(N)(=O)=O)cc1.,CN(C)c1ccc(C(=O)NCCS(N)(=O)=O)cc1,benzene ring
191024,Add a benzene ring to the molecule O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1.,O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1,benzene ring
100883,Add a carboxyl to the molecule COc1ccc(/C=C(/C#N)C(=O)N2CCC[C@H](C)CC2)cc1.,COc1ccc(/C=C(/C#N)C(=O)N2CCC[C@H](C)CC2)cc1,carboxyl
6483,Add a benzene ring to the molecule COC(=O)c1cc(NC(=O)CCc2nnc(-c3ccoc3C)o2)ccc1C.,COC(=O)c1cc(NC(=O)CCc2nnc(-c3ccoc3C)o2)ccc1C,benzene ring
13463,Please add a amide to the molecule COc1ccc(-c2nc(C(=O)NCc3nnc4n3CCC4)cs2)cc1OC.,COc1ccc(-c2nc(C(=O)NCc3nnc4n3CCC4)cs2)cc1OC,amide
239462,Modify the molecule COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1 by adding a nitro.,COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1,nitro
176848,Please add a nitro to the molecule CC(C)n1cc(NC(=O)C2CCN(S(=O)(=O)c3cccnc3)CC2)cn1.,CC(C)n1cc(NC(=O)C2CCN(S(=O)(=O)c3cccnc3)CC2)cn1,nitro
58223,Add a carboxyl to the molecule CC(C)(C)n1cc(CN2CCS(=O)(=O)CC2)c(-c2ccccc2Cl)n1.,CC(C)(C)n1cc(CN2CCS(=O)(=O)CC2)c(-c2ccccc2Cl)n1,carboxyl
99671,Add a nitro to the molecule CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O.,CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O,nitro
31013,Add a amine to the molecule Cc1ccsc1CNS(=O)(=O)c1ccc(C(=O)[O-])s1.,Cc1ccsc1CNS(=O)(=O)c1ccc(C(=O)[O-])s1,amine
71849,Please add a amine to the molecule O=C(CC[NH+]1CCCC1)N1CCN(c2ncccn2)CC1.,O=C(CC[NH+]1CCCC1)N1CCN(c2ncccn2)CC1,amine
186402,Please add a amine to the molecule COc1cccc(-n2c(N)[nH+]c3ccccc32)c1.,COc1cccc(-n2c(N)[nH+]c3ccccc32)c1,amine
2525,Add a benzene ring to the molecule Cc1ccc(NC(=O)NCc2cccc(Cn3cncn3)c2)cc1C(N)=O.,Cc1ccc(NC(=O)NCc2cccc(Cn3cncn3)c2)cc1C(N)=O,benzene ring
202963,Please add a hydroxyl to the molecule CC1=C[C@@H](c2c(C)sc(C)c2S(=O)(=O)NC2CCCCCC2)N=N1.,CC1=C[C@@H](c2c(C)sc(C)c2S(=O)(=O)NC2CCCCCC2)N=N1,hydroxyl
205749,Please add a benzene ring to the molecule CC[C@H]([NH2+]Cc1ccc(F)c(Br)c1)c1ccccc1OC.,CC[C@H]([NH2+]Cc1ccc(F)c(Br)c1)c1ccccc1OC,benzene ring
106963,Add a amine to the molecule c1ccc(CC[NH+]2CCC[C@@H](c3cccc(-n4ccnc4)n3)C2)cc1.,c1ccc(CC[NH+]2CCC[C@@H](c3cccc(-n4ccnc4)n3)C2)cc1,amine
5843,Please add a benzene ring to the molecule COc1cccc(C(=O)N[C@@H](C)c2ccc(C)o2)n1.,COc1cccc(C(=O)N[C@@H](C)c2ccc(C)o2)n1,benzene ring
196967,Modify the molecule C[C@H](NC(=O)C[NH+]1CCC(O)CC1)c1cccc2ccccc12 by adding a halo.,C[C@H](NC(=O)C[NH+]1CCC(O)CC1)c1cccc2ccccc12,halo
169275,Add a hydroxyl to the molecule O=C(NCC[NH+]1CCCCC1)N1CCN(C(=O)c2ccoc2)CC1.,O=C(NCC[NH+]1CCCCC1)N1CCN(C(=O)c2ccoc2)CC1,hydroxyl
231709,Modify the molecule CC[C@H]1S/C(=N/N=C/c2cc(Br)ccc2OC)N(Cc2ccccc2C)C1=O by adding a hydroxyl.,CC[C@H]1S/C(=N/N=C/c2cc(Br)ccc2OC)N(Cc2ccccc2C)C1=O,hydroxyl
49415,Add a benzene ring to the molecule COC(=O)N1CCC[C@H](NC(=O)[C@@H](C)Cc2c(C)n[nH]c2C)C1.,COC(=O)N1CCC[C@H](NC(=O)[C@@H](C)Cc2c(C)n[nH]c2C)C1,benzene ring
125145,Please add a benzene ring to the molecule CN([C@@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)OCCCO2.,CN([C@@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)OCCCO2,benzene ring
64763,Add a amide to the molecule CCOC(=O)N/N=C1\CCCc2oc(C(=O)Nc3cccc4ccccc34)c(C)c21.,CCOC(=O)N/N=C1\CCCc2oc(C(=O)Nc3cccc4ccccc34)c(C)c21,amide
132130,Add a benzene ring to the molecule Cc1cccc(O[C@H](C)C(=O)Nc2ccccc2C(=O)N[C@@H](C)c2ccccc2)c1.,Cc1cccc(O[C@H](C)C(=O)Nc2ccccc2C(=O)N[C@@H](C)c2ccccc2)c1,benzene ring
40722,Add a carboxyl to the molecule CCOc1ccc(NC(=O)C(=O)NCC2CCN(c3nc4ccccc4o3)CC2)cc1.,CCOc1ccc(NC(=O)C(=O)NCC2CCN(c3nc4ccccc4o3)CC2)cc1,carboxyl
192601,Modify the molecule CN[C@@]1(C#N)CCC[C@@H]1CCOCC(C)C by adding a nitro.,CN[C@@]1(C#N)CCC[C@@H]1CCOCC(C)C,nitro
42935,Please add a halo to the molecule N#Cc1nc(COc2cccc(Cl)c2)oc1N1CCCCCC1.,N#Cc1nc(COc2cccc(Cl)c2)oc1N1CCCCCC1,halo
209647,Add a hydroxyl to the molecule CCOC(=O)/C=C/COc1ccc(F)cc1Br.,CCOC(=O)/C=C/COc1ccc(F)cc1Br,hydroxyl
33095,Please add a hydroxyl to the molecule O=C(NCc1cc(F)ccc1Br)NC[C@H](O)c1ccco1.,O=C(NCc1cc(F)ccc1Br)NC[C@H](O)c1ccco1,hydroxyl
219707,Modify the molecule CCOc1ccc2c(c1)[C@@H](N[C@H](C)[C@H](O)c1ccc(OC)cc1)CCO2 by adding a hydroxyl.,CCOc1ccc2c(c1)[C@@H](N[C@H](C)[C@H](O)c1ccc(OC)cc1)CCO2,hydroxyl
181329,Add a hydroxyl to the molecule CSC[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C1.,CSC[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C1,hydroxyl
193290,Please add a benzene ring to the molecule C[C@@H](Sc1nnc(Nc2ccccc2F)s1)C(=O)N1CCc2ccccc21.,C[C@@H](Sc1nnc(Nc2ccccc2F)s1)C(=O)N1CCc2ccccc21,benzene ring
54985,Please add a carboxyl to the molecule CCOC(=O)CCN1CC[S@@](=O)C(C)(C)C1.,CCOC(=O)CCN1CC[S@@](=O)C(C)(C)C1,carboxyl
184368,Add a amine to the molecule CCOc1ccc(N2C(=O)[C@@H](C)CS2(=O)=O)cc1S(=O)(=O)N[C@@H]1CCCc2ccccc21.,CCOc1ccc(N2C(=O)[C@@H](C)CS2(=O)=O)cc1S(=O)(=O)N[C@@H]1CCCc2ccccc21,amine
52939,Add a hydroxyl to the molecule Cc1ccc(CNC(=O)c2cccc(NC(=O)[C@@H]3C[C@@H]3C)c2)c(N(C)C)c1.,Cc1ccc(CNC(=O)c2cccc(NC(=O)[C@@H]3C[C@@H]3C)c2)c(N(C)C)c1,hydroxyl
72656,Add a benzene ring to the molecule CCCCN(C)C(=O)C(=O)Nc1cc(Cl)ccc1Cl.,CCCCN(C)C(=O)C(=O)Nc1cc(Cl)ccc1Cl,benzene ring
48880,Add a nitro to the molecule COc1ccc(-c2csc(NC(=O)COC(=O)C3CC3)n2)cc1.,COc1ccc(-c2csc(NC(=O)COC(=O)C3CC3)n2)cc1,nitro
60930,Please add a amide to the molecule CC(C)(C)OC(=O)N1CC(=CC(=O)NC2CC=CC2)C1.,CC(C)(C)OC(=O)N1CC(=CC(=O)NC2CC=CC2)C1,amide
124928,Add a carboxyl to the molecule CNc1ccnc([C@H]2CN3CCC[C@@H]3CO2)n1.,CNc1ccnc([C@H]2CN3CCC[C@@H]3CO2)n1,carboxyl
61595,Please add a benzene ring to the molecule COCCC[n+]1c(N)c(C(=O)NC[C@H]2CCCO2)cc2c(=O)n3ccccc3nc21.,COCCC[n+]1c(N)c(C(=O)NC[C@H]2CCCO2)cc2c(=O)n3ccccc3nc21,benzene ring
146348,Add a benzene ring to the molecule Cc1ccccc1C1(CNC(=O)NCc2ccc(C(N)=O)o2)CC1.,Cc1ccccc1C1(CNC(=O)NCc2ccc(C(N)=O)o2)CC1,benzene ring
82470,Add a hydroxyl to the molecule CC(C)NC(=O)C1CC[NH+](C2CCC(C(C)C)CC2)CC1.,CC(C)NC(=O)C1CC[NH+](C2CCC(C(C)C)CC2)CC1,hydroxyl
119609,Modify the molecule C[C@]1(CNS(=O)(=O)c2cncc(Br)c2)CCCO1 by adding a halo.,C[C@]1(CNS(=O)(=O)c2cncc(Br)c2)CCCO1,halo
226888,Add a benzene ring to the molecule CCN(C(=O)c1cc(S(=O)(=O)N(C)C)oc1C)[C@H]1CCCC[C@@H]1C.,CCN(C(=O)c1cc(S(=O)(=O)N(C)C)oc1C)[C@H]1CCCC[C@@H]1C,benzene ring
153687,Modify the molecule O=C(CSc1ccc(Cl)cc1)Nc1cccc(NC(=O)c2ccco2)c1 by adding a halo.,O=C(CSc1ccc(Cl)cc1)Nc1cccc(NC(=O)c2ccco2)c1,halo
132495,Add a benzene ring to the molecule CC(C)c1ocnc1Cn1nnc(CN(C)C(=O)c2ccccc2)n1.,CC(C)c1ocnc1Cn1nnc(CN(C)C(=O)c2ccccc2)n1,benzene ring
60007,Please add a nitro to the molecule O=C(NCc1cccc(NC(=O)[C@H]2CCCO2)c1)C1C2CC3CC(C2)CC1C3.,O=C(NCc1cccc(NC(=O)[C@H]2CCCO2)c1)C1C2CC3CC(C2)CC1C3,nitro
200964,Please add a benzene ring to the molecule CCS[C@@H]1CC[C@@H]([NH+](C)Cc2nnc(-c3ccccc3Cl)o2)C1.,CCS[C@@H]1CC[C@@H]([NH+](C)Cc2nnc(-c3ccccc3Cl)o2)C1,benzene ring
80677,Modify the molecule Cc1ccc2occ(/C=N\NC(=O)c3csc4ccccc34)c(=O)c2c1 by adding a amide.,Cc1ccc2occ(/C=N\NC(=O)c3csc4ccccc34)c(=O)c2c1,amide
1693,Please add a benzene ring to the molecule Cc1ccc(NC(=O)C(=O)N2CC[C@H]([NH+]3CCCC3)C2)cc1C(=O)N(C)C.,Cc1ccc(NC(=O)C(=O)N2CC[C@H]([NH+]3CCCC3)C2)cc1C(=O)N(C)C,benzene ring
15919,Add a amide to the molecule c1nc(N2CCC[C@H]([NH+]3CCCC3)C2)c2ccsc2n1.,c1nc(N2CCC[C@H]([NH+]3CCCC3)C2)c2ccsc2n1,amide
230044,Add a nitro to the molecule C[NH2+][C@@H](Cc1cccc(F)c1F)c1ccc(OC)cc1Br.,C[NH2+][C@@H](Cc1cccc(F)c1F)c1ccc(OC)cc1Br,nitro
173226,Add a aldehyde to the molecule C=CCN(Cc1ccccc1OCC)C(=O)c1nc([O-])c2ccccc2n1.,C=CCN(Cc1ccccc1OCC)C(=O)c1nc([O-])c2ccccc2n1,aldehyde
39662,Add a benzene ring to the molecule CN1C(=O)/C(=C\NCCN2CC[NH2+]CC2)C(=O)N(c2ccccc2)C1=S.,CN1C(=O)/C(=C\NCCN2CC[NH2+]CC2)C(=O)N(c2ccccc2)C1=S,benzene ring
142823,Please add a benzene ring to the molecule Cc1ccc(C[C@]2(O)CC(C)(C)OC2(C)C)cc1C.,Cc1ccc(C[C@]2(O)CC(C)(C)OC2(C)C)cc1C,benzene ring
79052,Add a benzene ring to the molecule O=C(CN1CC[NH+](C[C@@H](O)C2CC2)CC1)NCc1ccccc1.,O=C(CN1CC[NH+](C[C@@H](O)C2CC2)CC1)NCc1ccccc1,benzene ring
40487,Modify the molecule COc1ccc(-c2ccc(C=O)o2)cc1[N+](=O)[O-] by adding a aldehyde.,COc1ccc(-c2ccc(C=O)o2)cc1[N+](=O)[O-],aldehyde
158975,Add a hydroxyl to the molecule COCCOc1ccccc1C(=O)Nc1cccc(Cl)c1.,COCCOc1ccccc1C(=O)Nc1cccc(Cl)c1,hydroxyl
15922,Please add a amide to the molecule CC(=O)Nc1cccc(C(=O)/C=C/c2ccccc2)c1.,CC(=O)Nc1cccc(C(=O)/C=C/c2ccccc2)c1,amide
126461,Please add a hydroxyl to the molecule CCCC(=O)N1CCC[C@@H]1C(=O)NNc1cc(C#N)cc(Cl)n1.,CCCC(=O)N1CCC[C@@H]1C(=O)NNc1cc(C#N)cc(Cl)n1,hydroxyl
131470,Modify the molecule COc1ccc([C@@H]2C[C@@H](C)N(Cc3noc(C4CC4)n3)C2)cc1 by adding a halo.,COc1ccc([C@@H]2C[C@@H](C)N(Cc3noc(C4CC4)n3)C2)cc1,halo
54992,Modify the molecule C[C@H](SCc1cccc(C(=O)N(C)C)c1)c1cccs1 by adding a aldehyde.,C[C@H](SCc1cccc(C(=O)N(C)C)c1)c1cccs1,aldehyde
105270,Modify the molecule Cc1cc(Cl)ccc1NC(=O)CN(c1cc(Cl)ccc1Cl)S(C)(=O)=O by adding a amide.,Cc1cc(Cl)ccc1NC(=O)CN(c1cc(Cl)ccc1Cl)S(C)(=O)=O,amide
142709,Please add a amide to the molecule CC1(c2nc(C3CCCCC3)n[nH]2)CCCC1.,CC1(c2nc(C3CCCCC3)n[nH]2)CCCC1,amide
47533,Modify the molecule COc1ccc2c(c1)CCC1=C2N=N[C@@H]1c1nc(-c2ccc(OC)c(OC)c2)no1 by adding a carboxyl.,COc1ccc2c(c1)CCC1=C2N=N[C@@H]1c1nc(-c2ccc(OC)c(OC)c2)no1,carboxyl
96095,Modify the molecule CNC(=O)CC1CCN(C(=O)C[C@H]2C[C@H]3CC[C@@H]2C3)CC1 by adding a amine.,CNC(=O)CC1CCN(C(=O)C[C@H]2C[C@H]3CC[C@@H]2C3)CC1,amine
88245,Modify the molecule COc1ccc(CNC(=O)[C@H](C)N2C(=O)c3ccccc3C2=O)cc1 by adding a benzene ring.,COc1ccc(CNC(=O)[C@H](C)N2C(=O)c3ccccc3C2=O)cc1,benzene ring
215660,Please add a hydroxyl to the molecule Cc1ccc(NC(=O)N2CSC[C@H]2C(=O)[O-])cc1.,Cc1ccc(NC(=O)N2CSC[C@H]2C(=O)[O-])cc1,hydroxyl
139880,Add a amide to the molecule S=C(Nc1ccccc1)N1CCC(Cc2ccccc2)CC1.,S=C(Nc1ccccc1)N1CCC(Cc2ccccc2)CC1,amide
114978,Modify the molecule C[C@H](c1ccccc1Cl)N(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1 by adding a hydroxyl.,C[C@H](c1ccccc1Cl)N(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,hydroxyl
101517,Add a benzene ring to the molecule CCOC(=O)[C@](C)(O)[C@H](C)c1cc(F)cc(F)c1.,CCOC(=O)[C@](C)(O)[C@H](C)c1cc(F)cc(F)c1,benzene ring
142177,Modify the molecule Cc1cccc[n+]1CC(=O)Nc1ccc(/N=N/c2ccccc2)cc1 by adding a hydroxyl.,Cc1cccc[n+]1CC(=O)Nc1ccc(/N=N/c2ccccc2)cc1,hydroxyl
43191,Modify the molecule Cc1noc(C)c1COC(=O)Cn1c(C(F)(F)F)nc2ccccc21 by adding a aldehyde.,Cc1noc(C)c1COC(=O)Cn1c(C(F)(F)F)nc2ccccc21,aldehyde
123754,Modify the molecule C/C(=C/C(=O)N1CC[C@@H](C)[C@H](O)C1)c1ccccc1F by adding a amine.,C/C(=C/C(=O)N1CC[C@@H](C)[C@H](O)C1)c1ccccc1F,amine
211891,Please add a carboxyl to the molecule O=S(=O)(c1cc(F)ccc1F)N1CCN(Cc2cccc3ccccc23)CC1.,O=S(=O)(c1cc(F)ccc1F)N1CCN(Cc2cccc3ccccc23)CC1,carboxyl
152746,Please add a amide to the molecule CC(=O)c1ccc(N2C(=O)c3oc4ccc(F)cc4c(=O)c3[C@H]2c2ccccc2)cc1.,CC(=O)c1ccc(N2C(=O)c3oc4ccc(F)cc4c(=O)c3[C@H]2c2ccccc2)cc1,amide
164148,Please add a nitro to the molecule Cc1cc(C(F)(F)F)nn1CC(=O)NN1C(=O)c2ccccc2C1=O.,Cc1cc(C(F)(F)F)nn1CC(=O)NN1C(=O)c2ccccc2C1=O,nitro
144814,Please add a nitro to the molecule CNC(=O)C1(NC(=O)[C@H](C)NC(=O)c2ccco2)CCCCC1.,CNC(=O)C1(NC(=O)[C@H](C)NC(=O)c2ccco2)CCCCC1,nitro
16153,Add a hydroxyl to the molecule O=C(NCCc1ccsc1)c1cc(-c2ccccc2)on1.,O=C(NCCc1ccsc1)c1cc(-c2ccccc2)on1,hydroxyl
65561,Please add a benzene ring to the molecule Cc1nc(C)n(-c2ccccc2NC(=O)[C@@H]2COc3ccc(F)cc3C2)n1.,Cc1nc(C)n(-c2ccccc2NC(=O)[C@@H]2COc3ccc(F)cc3C2)n1,benzene ring
41907,Add a nitro to the molecule CCCC1=C2[C@H](N=N1)OC(N)=C(C#N)[C@@H]2c1ccccc1.,CCCC1=C2[C@H](N=N1)OC(N)=C(C#N)[C@@H]2c1ccccc1,nitro
58170,Add a amide to the molecule Nc1nonc1Nc1n[nH]nc1-c1ccc(Cl)cc1.,Nc1nonc1Nc1n[nH]nc1-c1ccc(Cl)cc1,amide
95464,Add a carboxyl to the molecule CCn1/c(=N/C(=O)[C@@H]2CC(=O)N(C)C2)[nH]c2ccc(Br)cc21.,CCn1/c(=N/C(=O)[C@@H]2CC(=O)N(C)C2)[nH]c2ccc(Br)cc21,carboxyl
105010,Please add a benzene ring to the molecule CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1.,CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1,benzene ring
38331,Add a carboxyl to the molecule COc1ccc(CNC(=O)Cn2cnc3scc(-c4ccc(C)s4)c3c2=O)cc1OC.,COc1ccc(CNC(=O)Cn2cnc3scc(-c4ccc(C)s4)c3c2=O)cc1OC,carboxyl
80472,Add a nitro to the molecule COc1c(C)c[nH+]c(CN2CCC[C@@H]2C[NH+]2CCCCC2)c1C.,COc1c(C)c[nH+]c(CN2CCC[C@@H]2C[NH+]2CCCCC2)c1C,nitro
24040,Please add a aldehyde to the molecule CC[C@@H]1CN(C[C@@H](CS)c2ccccc2)CC[NH+]1C.,CC[C@@H]1CN(C[C@@H](CS)c2ccccc2)CC[NH+]1C,aldehyde
81645,Please add a hydroxyl to the molecule COC(=O)c1ccc(Oc2ncnc(Oc3cccc4cccnc34)c2[N+](=O)[O-])cc1.,COC(=O)c1ccc(Oc2ncnc(Oc3cccc4cccnc34)c2[N+](=O)[O-])cc1,hydroxyl
78304,Add a nitro to the molecule COc1cccc(C[C@H](C)N[C@@H](C)c2cccs2)c1.,COc1cccc(C[C@H](C)N[C@@H](C)c2cccs2)c1,nitro
193376,Modify the molecule Cn1c(CN2CCC[C@H]2c2noc(C3CC3)n2)nnc1C1CC1 by adding a amide.,Cn1c(CN2CCC[C@H]2c2noc(C3CC3)n2)nnc1C1CC1,amide
75745,Add a benzene ring to the molecule O=C(NC[C@@]1(O)CCCN(C(=O)c2cc(C3CC3)n[nH]2)CC1)N1CCCC1.,O=C(NC[C@@]1(O)CCCN(C(=O)c2cc(C3CC3)n[nH]2)CC1)N1CCCC1,benzene ring
7904,Modify the molecule Cc1ccc(SCCCC(=O)Nc2nnc(-c3ccccc3)o2)cc1 by adding a aldehyde.,Cc1ccc(SCCCC(=O)Nc2nnc(-c3ccccc3)o2)cc1,aldehyde
116235,Please add a hydroxyl to the molecule CCOc1ccc(Cc2nc3ccc(OC)cc3c(=O)[nH]2)cc1.,CCOc1ccc(Cc2nc3ccc(OC)cc3c(=O)[nH]2)cc1,hydroxyl
221203,Add a amide to the molecule COc1ccc(NC(=S)N/N=C(/C)c2ccc3ccccc3c2)cc1.,COc1ccc(NC(=S)N/N=C(/C)c2ccc3ccccc3c2)cc1,amide
44091,Add a amide to the molecule O=C(N[C@H](c1ccc(Cl)cc1)C1CC1)c1ccc(-n2cccn2)cc1.,O=C(N[C@H](c1ccc(Cl)cc1)C1CC1)c1ccc(-n2cccn2)cc1,amide
26277,Please add a benzene ring to the molecule CCC[NH+]1CCC(N(C)C(=O)NC[C@H](C)C[NH+]2CCN(C)CC2)CC1.,CCC[NH+]1CCC(N(C)C(=O)NC[C@H](C)C[NH+]2CCN(C)CC2)CC1,benzene ring
111747,Add a benzene ring to the molecule Cc1ccc(NC(=O)Cn2ccc3ccccc32)c(N)c1.,Cc1ccc(NC(=O)Cn2ccc3ccccc32)c(N)c1,benzene ring
22956,Please add a amide to the molecule Cc1ccc([C@H](C)[NH2+][C@@H]2CCO[C@]3(CCOC3)C2)o1.,Cc1ccc([C@H](C)[NH2+][C@@H]2CCO[C@]3(CCOC3)C2)o1,amide
14123,Modify the molecule CCCC[NH+](C)Cc1ccccc1N1CCOCC1 by adding a amide.,CCCC[NH+](C)Cc1ccccc1N1CCOCC1,amide
204342,Please add a halo to the molecule CC(=O)c1cc(C(=O)NC[C@H]2CC[C@H](C(=O)[O-])O2)n(C)c1.,CC(=O)c1cc(C(=O)NC[C@H]2CC[C@H](C(=O)[O-])O2)n(C)c1,halo
95768,Modify the molecule CC[NH2+][C@@H](CSC1CCCCC1)[C@H]1CCOC2(CCC2)C1 by adding a benzene ring.,CC[NH2+][C@@H](CSC1CCCCC1)[C@H]1CCOC2(CCC2)C1,benzene ring
223528,Modify the molecule O=C(NCc1nncn1C1CC1)C1(c2cccc(F)c2)CCOCC1 by adding a hydroxyl.,O=C(NCc1nncn1C1CC1)C1(c2cccc(F)c2)CCOCC1,hydroxyl
8347,Please add a hydroxyl to the molecule CCC(=O)CCc1ccc(F)cc1Br.,CCC(=O)CCc1ccc(F)cc1Br,hydroxyl
216733,Add a amide to the molecule Cc1nn(C)c2nc(C3CC3)cc(C(=O)N[C@@H](C)c3ccccc3)c12.,Cc1nn(C)c2nc(C3CC3)cc(C(=O)N[C@@H](C)c3ccccc3)c12,amide
10631,Modify the molecule Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1 by adding a halo.,Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1,halo
95356,Modify the molecule Cc1oc2c(C)c3oc(=O)c(CC(=O)N[C@@H](C)CC4=c5ccccc5=[NH+]C4)c(C)c3cc2c1C by adding a hydroxyl.,Cc1oc2c(C)c3oc(=O)c(CC(=O)N[C@@H](C)CC4=c5ccccc5=[NH+]C4)c(C)c3cc2c1C,hydroxyl
182123,Please add a nitro to the molecule COCCNc1ncnc(Oc2cccc3ccc(C)nc23)c1[N+](=O)[O-].,COCCNc1ncnc(Oc2cccc3ccc(C)nc23)c1[N+](=O)[O-],nitro
95643,Modify the molecule CC[NH2+][C@H]1[C@H](Oc2ccccc2OC)CCC1(C)C by adding a nitrile.,CC[NH2+][C@H]1[C@H](Oc2ccccc2OC)CCC1(C)C,nitrile
40032,Add a benzene ring to the molecule O=C([O-])c1ccc(-n2cnc3ccccc32)nc1.,O=C([O-])c1ccc(-n2cnc3ccccc32)nc1,benzene ring
19466,Modify the molecule COc1cccc(C(=O)c2ccc(O)cc2)c1 by adding a amide.,COc1cccc(C(=O)c2ccc(O)cc2)c1,amide
222986,Modify the molecule N#CCc1ccc(NC(=O)CSc2ncnc3sccc23)cc1 by adding a nitro.,N#CCc1ccc(NC(=O)CSc2ncnc3sccc23)cc1,nitro
41229,Add a carboxyl to the molecule Cc1ncsc1C(=O)N[C@@H]1CCCOc2c1ccc1ccccc21.,Cc1ncsc1C(=O)N[C@@H]1CCCOc2c1ccc1ccccc21,carboxyl
200868,Add a benzene ring to the molecule COc1ccc(C(=O)OCCCc2nc3ccccc3s2)cn1.,COc1ccc(C(=O)OCCCc2nc3ccccc3s2)cn1,benzene ring
181694,Add a hydroxyl to the molecule CCOCCS(=O)(=O)N1CCNC[C@H]1C#N.,CCOCCS(=O)(=O)N1CCNC[C@H]1C#N,hydroxyl
245143,Please add a amide to the molecule C[C@@H]1CN(S(=O)(=O)N2CCC(OCc3ccc(F)cc3)CC2)CCO1.,C[C@@H]1CN(S(=O)(=O)N2CCC(OCc3ccc(F)cc3)CC2)CCO1,amide
40344,Modify the molecule C[C@H](Cc1cccs1)[NH+](C)CCn1nc2ccccn2c1=O by adding a aldehyde.,C[C@H](Cc1cccs1)[NH+](C)CCn1nc2ccccn2c1=O,aldehyde
81212,Please add a nitrile to the molecule Cc1ccc(S[C@H](C)C(=O)N2CCC[C@@H](C(N)=O)C2)cc1.,Cc1ccc(S[C@H](C)C(=O)N2CCC[C@@H](C(N)=O)C2)cc1,nitrile
115556,Modify the molecule C=CCOc1ccc(/C=C2\SC(=S)N(c3ccc(OC)cc3OC)C2=O)cc1 by adding a aldehyde.,C=CCOc1ccc(/C=C2\SC(=S)N(c3ccc(OC)cc3OC)C2=O)cc1,aldehyde
178843,Modify the molecule Brc1cccc(C[NH+]2CCC(CN3CCOCC3)CC2)c1 by adding a amine.,Brc1cccc(C[NH+]2CCC(CN3CCOCC3)CC2)c1,amine
133712,Modify the molecule COc1ccc(F)cc1NC(=O)/C=C/c1csc(C)n1 by adding a aldehyde.,COc1ccc(F)cc1NC(=O)/C=C/c1csc(C)n1,aldehyde
240773,Please add a nitro to the molecule Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12.,Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12,nitro
93002,Please add a aldehyde to the molecule Cc1ccnc(N2CCCC[C@H]2C(=O)[O-])n1.,Cc1ccnc(N2CCCC[C@H]2C(=O)[O-])n1,aldehyde
162453,Please add a hydroxyl to the molecule Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)CCC(=O)N2C.,Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)CCC(=O)N2C,hydroxyl
131175,Add a benzene ring to the molecule NC(=O)CC[C@H]1CCCN(S(=O)(=O)Cc2cccc(C(F)(F)F)c2)C1.,NC(=O)CC[C@H]1CCCN(S(=O)(=O)Cc2cccc(C(F)(F)F)c2)C1,benzene ring
60102,Please add a hydroxyl to the molecule CCOc1ccc(NS(=O)(=O)c2ccc3c(c2)NC(=O)CCS3)cc1.,CCOc1ccc(NS(=O)(=O)c2ccc3c(c2)NC(=O)CCS3)cc1,hydroxyl
31354,Modify the molecule O=C(Nc1cccc(I)c1)c1ccc(CO)cc1 by adding a benzene ring.,O=C(Nc1cccc(I)c1)c1ccc(CO)cc1,benzene ring
39654,Please add a amide to the molecule Cc1ccc([C@@H]2C[C@@H]2C(=O)N2C[C@H](n3cccn3)Cc3ccccc32)s1.,Cc1ccc([C@@H]2C[C@@H]2C(=O)N2C[C@H](n3cccn3)Cc3ccccc32)s1,amide
233083,Modify the molecule Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12 by adding a amide.,Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12,amide
148947,Add a amine to the molecule CCC(CC)([C@H](O)c1ccc(C)s1)[NH+](C)C.,CCC(CC)([C@H](O)c1ccc(C)s1)[NH+](C)C,amine
116064,Add a benzene ring to the molecule Cc1ccc(Cc2cnc(NC(=O)[C@@H]3Oc4ccccc4O[C@@H]3C)s2)cc1.,Cc1ccc(Cc2cnc(NC(=O)[C@@H]3Oc4ccccc4O[C@@H]3C)s2)cc1,benzene ring
219227,Please add a aldehyde to the molecule CC(C)C[C@H](O)CNC(=O)Nc1ccc(-c2csnn2)cc1.,CC(C)C[C@H](O)CNC(=O)Nc1ccc(-c2csnn2)cc1,aldehyde
153828,Add a carboxyl to the molecule C/C(=N\NC(=O)OC(C)(C)C)c1ccc(Cl)c([N+](=O)[O-])c1.,C/C(=N\NC(=O)OC(C)(C)C)c1ccc(Cl)c([N+](=O)[O-])c1,carboxyl
82970,Please add a nitro to the molecule COc1ccc(OC(=O)Cc2ccc(F)c(F)c2)cc1.,COc1ccc(OC(=O)Cc2ccc(F)c(F)c2)cc1,nitro
57286,Please add a hydroxyl to the molecule O=C(Oc1ccc(Cl)cc1N1C(=O)[C@H]2CC=CC[C@@H]2C1=O)c1ccco1.,O=C(Oc1ccc(Cl)cc1N1C(=O)[C@H]2CC=CC[C@@H]2C1=O)c1ccco1,hydroxyl
147190,Please add a carboxyl to the molecule C[C@H](c1ccccc1)[NH+]1CC[C@H](NCC[NH+](C)C2CCCC2)C1.,C[C@H](c1ccccc1)[NH+]1CC[C@H](NCC[NH+](C)C2CCCC2)C1,carboxyl
59571,Add a benzene ring to the molecule Cc1ncncc1C(=O)NC1CC[NH+](Cc2cc(-c3ccc(F)cc3)nn2C)CC1.,Cc1ncncc1C(=O)NC1CC[NH+](Cc2cc(-c3ccc(F)cc3)nn2C)CC1,benzene ring
157050,Add a benzene ring to the molecule CC[C@@H](Sc1cc(C)ncn1)C(=O)Nc1nc2ccc(C)cc2s1.,CC[C@@H](Sc1cc(C)ncn1)C(=O)Nc1nc2ccc(C)cc2s1,benzene ring
56326,Please add a benzene ring to the molecule Fc1ccc(C2(C[NH2+]C3CCSCC3)CC2)cc1.,Fc1ccc(C2(C[NH2+]C3CCSCC3)CC2)cc1,benzene ring
28568,Please add a hydroxyl to the molecule COc1ccc(C)cc1-c1csc(NC(=O)c2ccccc2)n1.,COc1ccc(C)cc1-c1csc(NC(=O)c2ccccc2)n1,hydroxyl
239103,Modify the molecule Cc1cc(CCC(=O)Nc2c(C(N)=O)n[nH]c2C)ccc1Br by adding a aldehyde.,Cc1cc(CCC(=O)Nc2c(C(N)=O)n[nH]c2C)ccc1Br,aldehyde
242561,Add a amide to the molecule O=C(NCCCCn1cnnc1)c1c(F)cccc1F.,O=C(NCCCCn1cnnc1)c1c(F)cccc1F,amide
61297,Add a amide to the molecule C#Cc1cccc(NC(=O)c2ccccc2S(=O)(=O)N(C)c2ccccc2)c1.,C#Cc1cccc(NC(=O)c2ccccc2S(=O)(=O)N(C)c2ccccc2)c1,amide
160801,Modify the molecule C=CCNc1ncnc(Nc2ccc3c(c2)OCO3)c1N by adding a amide.,C=CCNc1ncnc(Nc2ccc3c(c2)OCO3)c1N,amide
110652,Please add a halo to the molecule COC[C@H](C)NC(=O)Nc1cccc(SC(F)F)c1.,COC[C@H](C)NC(=O)Nc1cccc(SC(F)F)c1,halo
223037,Modify the molecule COc1cc(OC)c(OC)cc1/C=C1\N=C(c2ccc(C)c(C)c2)OC1=O by adding a aldehyde.,COc1cc(OC)c(OC)cc1/C=C1\N=C(c2ccc(C)c(C)c2)OC1=O,aldehyde
188605,Please add a nitro to the molecule CCCNc1nc([C@@H]2CSCCS2)nc2sc(C)cc12.,CCCNc1nc([C@@H]2CSCCS2)nc2sc(C)cc12,nitro
62468,Modify the molecule Cc1ccc2c(CC(=O)N(C[C@H]3CCCCO3)C(C)C)c[nH]c2c1 by adding a benzene ring.,Cc1ccc2c(CC(=O)N(C[C@H]3CCCCO3)C(C)C)c[nH]c2c1,benzene ring
134870,Add a amide to the molecule CC(C)(CNC(=O)[C@H](C[NH3+])Cc1ccccc1)S(C)(=O)=O.,CC(C)(CNC(=O)[C@H](C[NH3+])Cc1ccccc1)S(C)(=O)=O,amide
81712,Please add a amine to the molecule Cn1c(CCCNC(=O)[C@H]2CCCO2)nc2cc(NC(=O)c3ccccc3)ccc21.,Cn1c(CCCNC(=O)[C@H]2CCCO2)nc2cc(NC(=O)c3ccccc3)ccc21,amine
174450,Add a amide to the molecule COc1ccccc1-c1cc(=O)[nH]c(N2CCN(c3ccc(F)cc3)CC2)n1.,COc1ccccc1-c1cc(=O)[nH]c(N2CCN(c3ccc(F)cc3)CC2)n1,amide
38900,Add a hydroxyl to the molecule CC[C@@H]1CCCC[C@@H]1OC(=O)CC1CC[NH2+]CC1.,CC[C@@H]1CCCC[C@@H]1OC(=O)CC1CC[NH2+]CC1,hydroxyl
104059,Modify the molecule Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1 by adding a amide.,Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1,amide
168577,Please add a carboxyl to the molecule Cc1n[nH]c(C)c1N[C@@H]1CC[C@H](NC(=O)OC(C)(C)C)C1.,Cc1n[nH]c(C)c1N[C@@H]1CC[C@H](NC(=O)OC(C)(C)C)C1,carboxyl
164833,Modify the molecule CCC(CC)(CC(=O)Nc1cccc(Br)c1)C(=O)[O-] by adding a hydroxyl.,CCC(CC)(CC(=O)Nc1cccc(Br)c1)C(=O)[O-],hydroxyl
48788,Please add a benzene ring to the molecule CC[C@H](NC(=O)/C=C/c1ccc(F)cc1)c1ccc2c(c1)OCCO2.,CC[C@H](NC(=O)/C=C/c1ccc(F)cc1)c1ccc2c(c1)OCCO2,benzene ring
62911,Add a benzene ring to the molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2Cl)C1.,Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2Cl)C1,benzene ring
96785,Please add a amide to the molecule O=[N+]([O-])c1c(C(F)(F)F)nn(-c2ccc(Cl)c(F)c2)c1Cl.,O=[N+]([O-])c1c(C(F)(F)F)nn(-c2ccc(Cl)c(F)c2)c1Cl,amide
4561,Please add a amide to the molecule CCC(=O)N(C)c1ccccc1C(=O)N[C@H](C)c1nc(C2CCCC2)no1.,CCC(=O)N(C)c1ccccc1C(=O)N[C@H](C)c1nc(C2CCCC2)no1,amide
154394,Add a aldehyde to the molecule Cc1cc([C@@H](C)Nc2ncncc2N)c(C)o1.,Cc1cc([C@@H](C)Nc2ncncc2N)c(C)o1,aldehyde
14740,Add a amide to the molecule CC(C)CNC(=O)c1ccc(NC(=O)NNC(=O)c2ccccc2)cc1.,CC(C)CNC(=O)c1ccc(NC(=O)NNC(=O)c2ccccc2)cc1,amide
30042,Please add a aldehyde to the molecule COc1ccc2cc3c([nH+]c2c1)N(c1ccc(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])cc1)CC3.,COc1ccc2cc3c([nH+]c2c1)N(c1ccc(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])cc1)CC3,aldehyde
236726,Add a benzene ring to the molecule CC(=O)N(C)Cc1ccccc1NCC1CC[NH2+]CC1.,CC(=O)N(C)Cc1ccccc1NCC1CC[NH2+]CC1,benzene ring
67074,Add a benzene ring to the molecule CC[NH+](C)Cc1cc(C(=O)OC)sc1C.,CC[NH+](C)Cc1cc(C(=O)OC)sc1C,benzene ring
57807,Please add a carboxyl to the molecule COC(=O)c1cc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)ccc1C.,COC(=O)c1cc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)ccc1C,carboxyl
216879,Add a halo to the molecule COC(=O)[C@@H]1C[C@H]1C(=O)N1CC[NH+](C2CC2)CC1.,COC(=O)[C@@H]1C[C@H]1C(=O)N1CC[NH+](C2CC2)CC1,halo
97800,Add a amide to the molecule Cc1cc(NC(=O)C[NH+]2CCC[C@H](C(=O)NCC(F)(F)F)C2)on1.,Cc1cc(NC(=O)C[NH+]2CCC[C@H](C(=O)NCC(F)(F)F)C2)on1,amide
144184,Please add a hydroxyl to the molecule C[C@H](NC(=O)c1c[nH]nc1-c1ccccc1F)[C@@H]1CCCO1.,C[C@H](NC(=O)c1c[nH]nc1-c1ccccc1F)[C@@H]1CCCO1,hydroxyl
171986,Modify the molecule CCc1nn(C)cc1NC(=O)CCNS(=O)(=O)c1ccccc1 by adding a amide.,CCc1nn(C)cc1NC(=O)CCNS(=O)(=O)c1ccccc1,amide
108558,Modify the molecule CO[C@@H](c1ccc(Cl)cc1)[C@H](C)NC(=O)N1CCOC(C)(C)C1 by adding a hydroxyl.,CO[C@@H](c1ccc(Cl)cc1)[C@H](C)NC(=O)N1CCOC(C)(C)C1,hydroxyl
191616,Modify the molecule CC(=O)O[C@@H](C)c1nc2ccc(C(=O)[O-])cc2[nH]1 by adding a amine.,CC(=O)O[C@@H](C)c1nc2ccc(C(=O)[O-])cc2[nH]1,amine
204029,Add a hydroxyl to the molecule CC(C)c1noc([C@@H](C)SCCOc2ccc(F)cc2)n1.,CC(C)c1noc([C@@H](C)SCCOc2ccc(F)cc2)n1,hydroxyl
187037,Add a halo to the molecule O=c1[nH]c2ccccc2c(=O)n1CCc1ccc(Cl)cc1.,O=c1[nH]c2ccccc2c(=O)n1CCc1ccc(Cl)cc1,halo
89671,Modify the molecule CCOc1ccccc1[C@@H](O)[C@@H](C)[C@@H](C)C(=O)[O-] by adding a carboxyl.,CCOc1ccccc1[C@@H](O)[C@@H](C)[C@@H](C)C(=O)[O-],carboxyl
77093,Modify the molecule CCC(CC)(CNc1nccc(C(F)(F)F)n1)S(C)(=O)=O by adding a benzene ring.,CCC(CC)(CNc1nccc(C(F)(F)F)n1)S(C)(=O)=O,benzene ring
96430,Please add a amine to the molecule CCCc1nc2sc3c(NCCN4CCOCC4)nc(SC)nc3c2c2c1CCC2.,CCCc1nc2sc3c(NCCN4CCOCC4)nc(SC)nc3c2c2c1CCC2,amine
68396,Add a hydroxyl to the molecule Cc1cc([C@@H](C)[NH2+]Cc2ccccc2Cl)c(C)s1.,Cc1cc([C@@H](C)[NH2+]Cc2ccccc2Cl)c(C)s1,hydroxyl
114897,Please add a hydroxyl to the molecule CCc1nn(C)cc1C(=O)NC[C@@H](C)Cn1nc(C)cc1C.,CCc1nn(C)cc1C(=O)NC[C@@H](C)Cn1nc(C)cc1C,hydroxyl
11161,Add a benzene ring to the molecule CO[C@H](C(=O)Nc1cccc(-c2ccnc(C)n2)c1)c1ccccc1.,CO[C@H](C(=O)Nc1cccc(-c2ccnc(C)n2)c1)c1ccccc1,benzene ring
228599,Add a amine to the molecule O=C(C[NH2+][C@H]1CCCN(c2cccnn2)C1)N1CCCC1.,O=C(C[NH2+][C@H]1CCCN(c2cccnn2)C1)N1CCCC1,amine
80581,Add a carboxyl to the molecule Cc1nc2c(s1)[C@H](NCc1ccnc(OC3CCC3)c1)CCC2.,Cc1nc2c(s1)[C@H](NCc1ccnc(OC3CCC3)c1)CCC2,carboxyl
174791,Add a benzene ring to the molecule O=C1N[C@H](C(=O)Nc2cnn(-c3ccccc3F)c2)CS1.,O=C1N[C@H](C(=O)Nc2cnn(-c3ccccc3F)c2)CS1,benzene ring
10069,Modify the molecule O=C1CCc2cc(OC(=O)/C=C/c3ccccc3OC(F)F)ccc2N1 by adding a benzene ring.,O=C1CCc2cc(OC(=O)/C=C/c3ccccc3OC(F)F)ccc2N1,benzene ring
5219,Please add a hydroxyl to the molecule CC[C@@H](C)NC(=O)C(=O)Nc1cccc(C#Cc2cccc(C(=O)OC)c2)c1.,CC[C@@H](C)NC(=O)C(=O)Nc1cccc(C#Cc2cccc(C(=O)OC)c2)c1,hydroxyl
177657,Add a benzene ring to the molecule CS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2cccnc2)c2ccc(Cl)cc2)c1.,CS(=O)(=O)c1cccc(S(=O)(=O)N(Cc2cccnc2)c2ccc(Cl)cc2)c1,benzene ring
102284,Modify the molecule COc1ccccc1N1C(N)=[NH+]C[C@@]1(C)c1ccccn1 by adding a carboxyl.,COc1ccccc1N1C(N)=[NH+]C[C@@]1(C)c1ccccn1,carboxyl
226712,Modify the molecule CC(C)CCn1cc(C(=O)NC2CCCC2)c(=O)c(C(=O)N2CCN(c3ccccc3F)CC2)c1 by adding a nitro.,CC(C)CCn1cc(C(=O)NC2CCCC2)c(=O)c(C(=O)N2CCN(c3ccccc3F)CC2)c1,nitro
117272,Add a carboxyl to the molecule CC(C)c1nnc2ccc(N3CCC[C@H](C(=O)NCc4ccccc4Cl)C3)nn12.,CC(C)c1nnc2ccc(N3CCC[C@H](C(=O)NCc4ccccc4Cl)C3)nn12,carboxyl
148579,Add a hydroxyl to the molecule C[C@@H](NCCc1ccccc1F)c1ccc([N+](=O)[O-])cc1.,C[C@@H](NCCc1ccccc1F)c1ccc([N+](=O)[O-])cc1,hydroxyl
58517,Please add a hydroxyl to the molecule C[NH+]1CCN(c2ccc(NC(=O)c3cccnc3Cl)cn2)CC1.,C[NH+]1CCN(c2ccc(NC(=O)c3cccnc3Cl)cn2)CC1,hydroxyl
125187,Add a hydroxyl to the molecule Fc1ccc(C[C@H]2CCCC[NH2+]2)cc1.,Fc1ccc(C[C@H]2CCCC[NH2+]2)cc1,hydroxyl
173898,Modify the molecule CCNC1(C#N)CCC(C)CC1 by adding a aldehyde.,CCNC1(C#N)CCC(C)CC1,aldehyde
1772,Modify the molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(F)cc3)C2)s1 by adding a carboxyl.,C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(F)cc3)C2)s1,carboxyl
46042,Modify the molecule Cc1cc(N2CCN(C(=O)c3cc4ccccc4o3)CC2)nc(C)[nH+]1 by adding a hydroxyl.,Cc1cc(N2CCN(C(=O)c3cc4ccccc4o3)CC2)nc(C)[nH+]1,hydroxyl
195467,Add a carboxyl to the molecule COc1cc(C)c(CN2CCN(C(=O)c3ccc(N4CCCCC4)c([N+](=O)[O-])c3)CC2)cc1OC.,COc1cc(C)c(CN2CCN(C(=O)c3ccc(N4CCCCC4)c([N+](=O)[O-])c3)CC2)cc1OC,carboxyl
186574,Please add a hydroxyl to the molecule Cc1cc(NC(=O)[C@@H]2CSc3nc(C(C)(C)C)cc(=O)n3C2)ccc1Br.,Cc1cc(NC(=O)[C@@H]2CSc3nc(C(C)(C)C)cc(=O)n3C2)ccc1Br,hydroxyl
196451,Add a nitro to the molecule CCOc1ccc(/N=C2/NC(=O)[C@@H](CC(=O)Nc3ccc(Br)cc3)S2)cc1.,CCOc1ccc(/N=C2/NC(=O)[C@@H](CC(=O)Nc3ccc(Br)cc3)S2)cc1,nitro
111351,Please add a benzene ring to the molecule O=C(C[S@](=O)c1cccc(F)c1)Nc1cccc(C(F)(F)F)c1.,O=C(C[S@](=O)c1cccc(F)c1)Nc1cccc(C(F)(F)F)c1,benzene ring
177270,Add a hydroxyl to the molecule CC[NH+](CC)CC(=O)Nc1c(C)cccc1N.,CC[NH+](CC)CC(=O)Nc1c(C)cccc1N,hydroxyl
210384,Please add a halo to the molecule CC(C)C[C@H](NC(=O)Cc1ccon1)c1cccc(C(F)(F)F)c1.,CC(C)C[C@H](NC(=O)Cc1ccon1)c1cccc(C(F)(F)F)c1,halo
19483,Modify the molecule CNC(=O)[C@@H]1CCC[NH+]1Cc1cccc(OCc2ccc(F)cc2)c1 by adding a benzene ring.,CNC(=O)[C@@H]1CCC[NH+]1Cc1cccc(OCc2ccc(F)cc2)c1,benzene ring
102893,Add a amine to the molecule COC[C@@H]1CCCN(C(=O)N[C@@H](c2ccccn2)c2ccccc2OC)C1.,COC[C@@H]1CCCN(C(=O)N[C@@H](c2ccccn2)c2ccccc2OC)C1,amine
119800,Add a amide to the molecule CCOc1cc(C)ccc1NC(=O)c1nccn2ccnc12.,CCOc1cc(C)ccc1NC(=O)c1nccn2ccnc12,amide
127444,Please add a amide to the molecule C[C@H](NC(=O)Nc1cnn(CC(F)F)c1)c1nc(C(C)(C)C)no1.,C[C@H](NC(=O)Nc1cnn(CC(F)F)c1)c1nc(C(C)(C)C)no1,amide
153626,Add a hydroxyl to the molecule CCc1nc(=O)n([C@H]2CCCOC2)c(CC)c1CC(=O)[O-].,CCc1nc(=O)n([C@H]2CCCOC2)c(CC)c1CC(=O)[O-],hydroxyl
42416,Please add a benzene ring to the molecule N/C(=N/OC(=O)Nc1csc(-c2cccc(Cl)c2Cl)n1)c1ccc(Cl)cc1.,N/C(=N/OC(=O)Nc1csc(-c2cccc(Cl)c2Cl)n1)c1ccc(Cl)cc1,benzene ring
44286,Modify the molecule CN(C)C(=O)[C@@H]1CCCN(c2cncc(Cl)n2)C1 by adding a nitro.,CN(C)C(=O)[C@@H]1CCCN(c2cncc(Cl)n2)C1,nitro
180839,Modify the molecule Cc1cc(CSCC(=O)Nc2ccccc2Cc2ccccc2)on1 by adding a halo.,Cc1cc(CSCC(=O)Nc2ccccc2Cc2ccccc2)on1,halo
173913,Modify the molecule COc1c(C)cnc(CNC(=O)N(C)C[C@H](C)O)c1C by adding a benzene ring.,COc1c(C)cnc(CNC(=O)N(C)C[C@H](C)O)c1C,benzene ring
205026,Please add a benzene ring to the molecule CC(C)[C@](O)(C(=O)[O-])[C@@H](C)c1ccc2c(c1)OCCO2.,CC(C)[C@](O)(C(=O)[O-])[C@@H](C)c1ccc2c(c1)OCCO2,benzene ring
181738,Add a amide to the molecule O=C(C1=C(O)C(=O)N(CC[NH+]2CCOCC2)[C@H]1c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1.,O=C(C1=C(O)C(=O)N(CC[NH+]2CCOCC2)[C@H]1c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1,amide
230465,Modify the molecule COCCn1cc[nH+]c1C1CCN(C(=O)COc2cccc(F)c2)CC1 by adding a hydroxyl.,COCCn1cc[nH+]c1C1CCN(C(=O)COc2cccc(F)c2)CC1,hydroxyl
94180,Add a amide to the molecule COc1ccc([N+](=O)[O-])c(C(=O)NC[C@@](C)(O)c2ccsc2)c1.,COc1ccc([N+](=O)[O-])c(C(=O)NC[C@@](C)(O)c2ccsc2)c1,amide
47462,Add a hydroxyl to the molecule CNC(=O)[C@H]1CCCN(Cc2nc3c(s2)C[C@H](C)CC3)C1.,CNC(=O)[C@H]1CCCN(Cc2nc3c(s2)C[C@H](C)CC3)C1,hydroxyl
107509,Please add a benzene ring to the molecule COCCN1C(=O)C[C@@](CC(=O)N2C[C@H](C)O[C@H](C)C2)(c2ccccc2OC)C1=O.,COCCN1C(=O)C[C@@](CC(=O)N2C[C@H](C)O[C@H](C)C2)(c2ccccc2OC)C1=O,benzene ring
140812,Modify the molecule CN1C(=O)S/C(=C/c2ccccc2OCc2ccc(Br)cc2)C1=O by adding a amide.,CN1C(=O)S/C(=C/c2ccccc2OCc2ccc(Br)cc2)C1=O,amide
149125,Add a benzene ring to the molecule C[C@H]1CN(C(=O)C2CC2)[C@@H](C)CN1C(=O)C1CC1.,C[C@H]1CN(C(=O)C2CC2)[C@@H](C)CN1C(=O)C1CC1,benzene ring
46616,Add a halo to the molecule O=[N+]([O-])c1ccc([C@@H]2Nc3ccc([N+](=O)[O-])cc3[C@@H]3C=CC[C@H]32)cc1.,O=[N+]([O-])c1ccc([C@@H]2Nc3ccc([N+](=O)[O-])cc3[C@@H]3C=CC[C@H]32)cc1,halo
120799,Please add a hydroxyl to the molecule C[C@@H]1CN(C(=O)Nc2ccc(O)c(C(=O)[O-])c2)C[C@@H]1C.,C[C@@H]1CN(C(=O)Nc2ccc(O)c(C(=O)[O-])c2)C[C@@H]1C,hydroxyl
16410,Add a amine to the molecule CCCCCN(C)S(=O)(=O)c1cc(Cl)cc(C(=O)[O-])c1F.,CCCCCN(C)S(=O)(=O)c1cc(Cl)cc(C(=O)[O-])c1F,amine
124740,Please add a aldehyde to the molecule COc1cc(/C=C2\NC(=S)NC2=O)ccc1OCc1ccccc1Cl.,COc1cc(/C=C2\NC(=S)NC2=O)ccc1OCc1ccccc1Cl,aldehyde
231277,Add a amide to the molecule C[NH+]1CCCN(C(=O)[C@@H]2CN(C(=O)NCc3ccco3)CCO2)CC1.,C[NH+]1CCCN(C(=O)[C@@H]2CN(C(=O)NCc3ccco3)CCO2)CC1,amide
233570,Please add a benzene ring to the molecule CC(=O)c1cccc(O[C@@H](C)C(=O)Nc2ccc(C(=O)c3nccn3C)cc2)c1.,CC(=O)c1cccc(O[C@@H](C)C(=O)Nc2ccc(C(=O)c3nccn3C)cc2)c1,benzene ring
10304,Please add a amide to the molecule CC1CCN(C(=O)[C@H](C)Oc2ccccc2Cl)CC1.,CC1CCN(C(=O)[C@H](C)Oc2ccccc2Cl)CC1,amide
224856,Modify the molecule Cn1c(C[NH+](C)C[C@@H]2COc3ccccc3O2)cc(=O)n(C)c1=O by adding a benzene ring.,Cn1c(C[NH+](C)C[C@@H]2COc3ccccc3O2)cc(=O)n(C)c1=O,benzene ring
185651,Modify the molecule CCOc1ccc(N2C(=O)C(c3c([O-])[nH]c4ccc(Br)cc34)=NC2=S)cc1 by adding a amine.,CCOc1ccc(N2C(=O)C(c3c([O-])[nH]c4ccc(Br)cc34)=NC2=S)cc1,amine
223390,Modify the molecule COC[C@H](NC(=O)c1cc(-c2cccc(Cl)c2)no1)C(N)=O by adding a amide.,COC[C@H](NC(=O)c1cc(-c2cccc(Cl)c2)no1)C(N)=O,amide
131064,Add a carboxyl to the molecule COCCC1(C[NH2+][C@H]2CCOc3c(C(C)C)cccc32)CC1.,COCCC1(C[NH2+][C@H]2CCOc3c(C(C)C)cccc32)CC1,carboxyl
200664,Add a benzene ring to the molecule CN(C(=O)/C=C/c1ccccc1)C1CC[NH+](Cc2ccncc2)CC1.,CN(C(=O)/C=C/c1ccccc1)C1CC[NH+](Cc2ccncc2)CC1,benzene ring
123356,Please add a benzene ring to the molecule CCCC(=O)N1CCCC[C@@H]1C(=O)NN=C(c1ccccc1)c1ccccc1.,CCCC(=O)N1CCCC[C@@H]1C(=O)NN=C(c1ccccc1)c1ccccc1,benzene ring
80589,Add a carboxyl to the molecule CCC(CC)(CO)NC(=O)Nc1cc(Br)ccc1C.,CCC(CC)(CO)NC(=O)Nc1cc(Br)ccc1C,carboxyl
15508,Add a nitro to the molecule C[C@@H](NC(=O)c1ccc(F)nc1)c1cccc([N-]S(C)(=O)=O)c1.,C[C@@H](NC(=O)c1ccc(F)nc1)c1cccc([N-]S(C)(=O)=O)c1,nitro
133297,Modify the molecule CCNS(=O)(=O)[C@@H]1CC[NH+](Cc2nc(-c3ccc(F)cc3)no2)C1 by adding a hydroxyl.,CCNS(=O)(=O)[C@@H]1CC[NH+](Cc2nc(-c3ccc(F)cc3)no2)C1,hydroxyl
88506,Please add a hydroxyl to the molecule CSC[C@H](C)C(=O)N1CCN(Cc2nc(-c3ccccc3C)no2)CC1.,CSC[C@H](C)C(=O)N1CCN(Cc2nc(-c3ccccc3C)no2)CC1,hydroxyl
63588,Modify the molecule Cc1ccc(C2=NO[C@H]3CN(C(=O)C4CCN(S(C)(=O)=O)CC4)C[C@H]23)cc1 by adding a aldehyde.,Cc1ccc(C2=NO[C@H]3CN(C(=O)C4CCN(S(C)(=O)=O)CC4)C[C@H]23)cc1,aldehyde
155829,Modify the molecule O=C([C@@H]1COc2ccc(F)cc2C1)N1CCN(c2ccccc2)CC1 by adding a carboxyl.,O=C([C@@H]1COc2ccc(F)cc2C1)N1CCN(c2ccccc2)CC1,carboxyl
223240,Add a benzene ring to the molecule C[C@@H]1Cc2cc(S(=O)(=O)NCCC3=CCCCC3)ccc2N1C(=O)C1CC1.,C[C@@H]1Cc2cc(S(=O)(=O)NCCC3=CCCCC3)ccc2N1C(=O)C1CC1,benzene ring
238388,Please add a benzene ring to the molecule C[C@@H]1CCC[C@@]([C@H]([NH3+])Cc2cnn(C)c2)(N(C)C)C1.,C[C@@H]1CCC[C@@]([C@H]([NH3+])Cc2cnn(C)c2)(N(C)C)C1,benzene ring
163978,Modify the molecule c1cncc(Cc2nnc3n2CCN(c2nccc(C4CCCC4)n2)CC3)c1 by adding a aldehyde.,c1cncc(Cc2nnc3n2CCN(c2nccc(C4CCCC4)n2)CC3)c1,aldehyde
120502,Add a halo to the molecule Cc1ncc(CN2CCC[C@H]2c2noc(C3CC3)n2)s1.,Cc1ncc(CN2CCC[C@H]2c2noc(C3CC3)n2)s1,halo
17765,Add a halo to the molecule Cc1nc(-c2ccncc2)ncc1[C@@H](C)[NH2+]CC1CC1.,Cc1nc(-c2ccncc2)ncc1[C@@H](C)[NH2+]CC1CC1,halo
105066,Add a amine to the molecule C[C@H](NC(=O)Nc1cccc(C#N)c1)c1noc(Cc2ccccc2)n1.,C[C@H](NC(=O)Nc1cccc(C#N)c1)c1noc(Cc2ccccc2)n1,amine
37995,Modify the molecule Cc1ccc(CN(C)C(=O)N[C@H](C)COCC(C)C)s1 by adding a hydroxyl.,Cc1ccc(CN(C)C(=O)N[C@H](C)COCC(C)C)s1,hydroxyl
13893,Add a halo to the molecule COC[C@@H]1CCCN(C(=O)c2ccc(NCc3ccncc3C)nc2)C1.,COC[C@@H]1CCCN(C(=O)c2ccc(NCc3ccncc3C)nc2)C1,halo
225793,Please add a aldehyde to the molecule CCS[C@@H]1CCCCN(C(=O)NCCCCn2cc[nH+]c2C)C1.,CCS[C@@H]1CCCCN(C(=O)NCCCCn2cc[nH+]c2C)C1,aldehyde
140970,Modify the molecule Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCc4ccccc4C3)CC2=O)cc1 by adding a amine.,Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCc4ccccc4C3)CC2=O)cc1,amine
17102,Add a amide to the molecule Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccccc4C)s3)C2)cc1Cl.,Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccccc4C)s3)C2)cc1Cl,amide
11981,Modify the molecule Cc1noc([C@@H](C)OC(=O)[C@@H]2CC(=O)N(CC(F)(F)F)C2)n1 by adding a nitro.,Cc1noc([C@@H](C)OC(=O)[C@@H]2CC(=O)N(CC(F)(F)F)C2)n1,nitro
47176,Please add a benzene ring to the molecule CCc1c(C(=O)NCC(=O)NCC(C)C)cnn1-c1ccccn1.,CCc1c(C(=O)NCC(=O)NCC(C)C)cnn1-c1ccccn1,benzene ring
216532,Please add a hydroxyl to the molecule O=C(C1CC1)N1CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1.,O=C(C1CC1)N1CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1,hydroxyl
235188,Please add a amide to the molecule Cc1ccc(CN2C[C@H](C(=O)Nc3ccc(Br)cc3Cl)CC2=O)cc1.,Cc1ccc(CN2C[C@H](C(=O)Nc3ccc(Br)cc3Cl)CC2=O)cc1,amide
81881,Modify the molecule CCCNC(=O)[C@@H](NC(=O)N1CCn2c1nc1ccccc12)[C@@H](C)CC by adding a amine.,CCCNC(=O)[C@@H](NC(=O)N1CCn2c1nc1ccccc12)[C@@H](C)CC,amine
73274,Add a halo to the molecule Cc1nc(C[C@@H]2CCC[NH+](Cc3cnc(C)n3-c3ccccc3)C2)no1.,Cc1nc(C[C@@H]2CCC[NH+](Cc3cnc(C)n3-c3ccccc3)C2)no1,halo
163274,Add a carboxyl to the molecule CC(=O)Nc1ccc(NC(=O)CN2C(=O)C=C(c3ccccc3)Nc3ccccc32)cc1.,CC(=O)Nc1ccc(NC(=O)CN2C(=O)C=C(c3ccccc3)Nc3ccccc32)cc1,carboxyl
16513,Please add a nitro to the molecule CC1(Cc2ccc(Cl)s2)C[NH2+]C1.,CC1(Cc2ccc(Cl)s2)C[NH2+]C1,nitro
107966,Modify the molecule Cc1sc2nc(S)n(Cc3cccs3)c(=O)c2c1-c1ccccc1 by adding a hydroxyl.,Cc1sc2nc(S)n(Cc3cccs3)c(=O)c2c1-c1ccccc1,hydroxyl
53847,Modify the molecule O=S(=O)(Nc1nc(-c2ccccc2)cs1)c1cccc(F)c1 by adding a amide.,O=S(=O)(Nc1nc(-c2ccccc2)cs1)c1cccc(F)c1,amide
86618,Please add a benzene ring to the molecule CC(C)c1ccc2cc(C(=O)Nc3ccc(NC(=O)CN4CCOCC4)cc3)[nH]c2c1.,CC(C)c1ccc2cc(C(=O)Nc3ccc(NC(=O)CN4CCOCC4)cc3)[nH]c2c1,benzene ring
165539,Modify the molecule Cn1cc(-c2nc3cc(C(F)(F)F)ccc3n2Cc2ccccc2)c(=O)n(C)c1=O by adding a aldehyde.,Cn1cc(-c2nc3cc(C(F)(F)F)ccc3n2Cc2ccccc2)c(=O)n(C)c1=O,aldehyde
195723,Add a benzene ring to the molecule CNC(=O)c1ccc(CN(C)C(=O)C[C@@H](NC(C)=O)c2ccccc2)cc1.,CNC(=O)c1ccc(CN(C)C(=O)C[C@@H](NC(C)=O)c2ccccc2)cc1,benzene ring
114220,Add a hydroxyl to the molecule Cc1cc2c(cc1C)/C(=C/C(=O)[O-])CO2.,Cc1cc2c(cc1C)/C(=C/C(=O)[O-])CO2,hydroxyl
133479,Please add a amide to the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCCCC1.,Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCCCC1,amide
154181,Please add a aldehyde to the molecule CNC(=O)c1nn(CC(=O)N(C)[C@@H](C)CC(C)C)c(=O)c2ccccc12.,CNC(=O)c1nn(CC(=O)N(C)[C@@H](C)CC(C)C)c(=O)c2ccccc12,aldehyde
245753,Please add a hydroxyl to the molecule Cc1cc(C)n(-c2cncc(NCCCc3ccc(O)cc3)n2)n1.,Cc1cc(C)n(-c2cncc(NCCCc3ccc(O)cc3)n2)n1,hydroxyl
100212,Please add a nitro to the molecule COC(=O)c1nn(-c2ccc([O-])nn2)nc1C.,COC(=O)c1nn(-c2ccc([O-])nn2)nc1C,nitro
23707,Please add a hydroxyl to the molecule CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1.,CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1,hydroxyl
249439,Modify the molecule C[C@@H]([NH2+][C@H]1CCCc2cccnc21)c1ccncc1 by adding a nitro.,C[C@@H]([NH2+][C@H]1CCCc2cccnc21)c1ccncc1,nitro
104421,Please add a benzene ring to the molecule C[C@@H]1CN(C(=O)c2cccc3c2oc(=O)n3C)C(C)(C)CO1.,C[C@@H]1CN(C(=O)c2cccc3c2oc(=O)n3C)C(C)(C)CO1,benzene ring
248485,Please add a benzene ring to the molecule NC(=O)c1ccsc1NC(=O)c1oc2ccccc2c1CSCc1ccccc1.,NC(=O)c1ccsc1NC(=O)c1oc2ccccc2c1CSCc1ccccc1,benzene ring
18772,Add a amide to the molecule C/C(=N\NC(=O)CNc1cccc2ccccc12)c1cccc([N+](=O)[O-])c1.,C/C(=N\NC(=O)CNc1cccc2ccccc12)c1cccc([N+](=O)[O-])c1,amide
143603,Please add a aldehyde to the molecule Cc1cc(C(=O)CSc2nnnn2C[C@@H]2CCCO2)c(C)n1-c1ccc(Cl)cc1.,Cc1cc(C(=O)CSc2nnnn2C[C@@H]2CCCO2)c(C)n1-c1ccc(Cl)cc1,aldehyde
127146,Add a amine to the molecule Cn1c(=O)n(CC(=O)N2CCN(Cc3ccccc3)CC2)c2ccccc21.,Cn1c(=O)n(CC(=O)N2CCN(Cc3ccccc3)CC2)c2ccccc21,amine
45219,Modify the molecule Cc1nc(C)n(-c2ccc(C(=O)N(C3CCCC3)C3CC3)cc2)n1 by adding a halo.,Cc1nc(C)n(-c2ccc(C(=O)N(C3CCCC3)C3CC3)cc2)n1,halo
211218,Modify the molecule Cc1cc(C)c(C)c(S(=O)(=O)NC[C@H](O)Cc2ccccc2)c1C by adding a hydroxyl.,Cc1cc(C)c(C)c(S(=O)(=O)NC[C@H](O)Cc2ccccc2)c1C,hydroxyl
174768,Add a aldehyde to the molecule CN(C(=O)NCCOc1ccc(C#N)cc1)[C@H]1CCc2ccccc21.,CN(C(=O)NCCOc1ccc(C#N)cc1)[C@H]1CCc2ccccc21,aldehyde
191768,Modify the molecule Cc1cc(-c2nc(CC(=O)NC3CCCCC3)no2)c(C)n1C1CC1 by adding a nitro.,Cc1cc(-c2nc(CC(=O)NC3CCCCC3)no2)c(C)n1C1CC1,nitro
228288,Add a benzene ring to the molecule CN(CCc1cccs1)c1cc(Br)cc(F)c1C(N)=O.,CN(CCc1cccs1)c1cc(Br)cc(F)c1C(N)=O,benzene ring
46077,Please add a hydroxyl to the molecule CC(C)c1ccc2c(c1)[C@@]1(CC(O)=Nc3c1cnn3Cc1ccc(Cl)cc1)C(=O)N2.,CC(C)c1ccc2c(c1)[C@@]1(CC(O)=Nc3c1cnn3Cc1ccc(Cl)cc1)C(=O)N2,hydroxyl
53806,Please add a amine to the molecule COc1ccc2c(-c3ccccc3)c(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)oc2c1.,COc1ccc2c(-c3ccccc3)c(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)oc2c1,amine
96511,Modify the molecule COc1ccccc1[C@H]1CCCN1CCc1nc2ccccc2c(=O)[nH]1 by adding a benzene ring.,COc1ccccc1[C@H]1CCCN1CCc1nc2ccccc2c(=O)[nH]1,benzene ring
54521,Add a aldehyde to the molecule CCCc1c(-c2ccc(Cl)s2)n[nH]c1N.,CCCc1c(-c2ccc(Cl)s2)n[nH]c1N,aldehyde
185100,Modify the molecule CCc1ccsc1CNS(=O)(=O)Cc1cccc2cccnc12 by adding a benzene ring.,CCc1ccsc1CNS(=O)(=O)Cc1cccc2cccnc12,benzene ring
244293,Add a hydroxyl to the molecule COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21.,COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21,hydroxyl
122680,Modify the molecule CSC[C@@H](C)NC(=O)c1c[nH]c2nccc(Cl)c12 by adding a amine.,CSC[C@@H](C)NC(=O)c1c[nH]c2nccc(Cl)c12,amine
174141,Add a nitrile to the molecule Cc1nc2c(C)cccn2c1C(=O)C1=C([O-])C(=O)N(CCC[NH+](C)C)[C@@H]1c1ccc(F)cc1.,Cc1nc2c(C)cccn2c1C(=O)C1=C([O-])C(=O)N(CCC[NH+](C)C)[C@@H]1c1ccc(F)cc1,nitrile
75930,Modify the molecule CCN1CC[NH+](C[C@@H]2C=NN=C2c2ccc3cc(OC)ccc3c2)[C@@H](C)C1=O by adding a aldehyde.,CCN1CC[NH+](C[C@@H]2C=NN=C2c2ccc3cc(OC)ccc3c2)[C@@H](C)C1=O,aldehyde
242728,Please add a amide to the molecule CO[C@@H]1CCCN(C(=O)N[C@@H](c2nc(C)cs2)C2CC2)C1.,CO[C@@H]1CCCN(C(=O)N[C@@H](c2nc(C)cs2)C2CC2)C1,amide
139647,Modify the molecule NC(=O)c1c(F)cccc1O[C@@H](F)C(=O)[O-] by adding a amide.,NC(=O)c1c(F)cccc1O[C@@H](F)C(=O)[O-],amide
142667,Modify the molecule O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1COCCO1 by adding a carboxyl.,O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1COCCO1,carboxyl
25287,Modify the molecule CCOc1cc2c(cc1CSCc1nnnn1-c1ccccc1)O[C@H](C)C2 by adding a hydroxyl.,CCOc1cc2c(cc1CSCc1nnnn1-c1ccccc1)O[C@H](C)C2,hydroxyl
182927,Modify the molecule COc1ccc([C@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1 by adding a benzene ring.,COc1ccc([C@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1,benzene ring
174928,Modify the molecule Cc1cc(C(=O)Cn2cnc([N+](=O)[O-])c2)c(C)n1-c1nccs1 by adding a hydroxyl.,Cc1cc(C(=O)Cn2cnc([N+](=O)[O-])c2)c(C)n1-c1nccs1,hydroxyl
153875,Modify the molecule COC(=O)c1n[nH]c2ccc(NC(=O)c3cnn(CC(C)C)c3C3CC3)cc12 by adding a halo.,COC(=O)c1n[nH]c2ccc(NC(=O)c3cnn(CC(C)C)c3C3CC3)cc12,halo
69478,Modify the molecule Cc1c(C2CC2)n[nH]c1NC(=O)c1cc(C#N)cn1C by adding a hydroxyl.,Cc1c(C2CC2)n[nH]c1NC(=O)c1cc(C#N)cn1C,hydroxyl
105499,Modify the molecule Cc1ccc2nc3c(cc(C(=O)NCc4cccnc4)c(N)[n+]3Cc3cccnc3)c(=O)n2c1 by adding a hydroxyl.,Cc1ccc2nc3c(cc(C(=O)NCc4cccnc4)c(N)[n+]3Cc3cccnc3)c(=O)n2c1,hydroxyl
21174,Modify the molecule Cc1ccc(CN(C(=O)c2cnccn2)[C@H](C(=O)Nc2ccc(F)cc2)c2ccccc2C)cc1 by adding a amide.,Cc1ccc(CN(C(=O)c2cnccn2)[C@H](C(=O)Nc2ccc(F)cc2)c2ccccc2C)cc1,amide
49236,Modify the molecule COc1cccc(CN(C)S(=O)(=O)N[C@H](C)c2ccccc2C)c1 by adding a hydroxyl.,COc1cccc(CN(C)S(=O)(=O)N[C@H](C)c2ccccc2C)c1,hydroxyl
13003,Please add a hydroxyl to the molecule CC[C@H](Sc1nnc2c3ccccc3n(C(C)C)c2n1)C(=O)Nc1nnc(C)s1.,CC[C@H](Sc1nnc2c3ccccc3n(C(C)C)c2n1)C(=O)Nc1nnc(C)s1,hydroxyl
54570,Add a carboxyl to the molecule COc1ccc([C@@H]2C(C(=O)c3cc4ccccc4o3)=C([O-])C(=O)N2c2nc(C)cs2)cc1.,COc1ccc([C@@H]2C(C(=O)c3cc4ccccc4o3)=C([O-])C(=O)N2c2nc(C)cs2)cc1,carboxyl
85461,Please add a amide to the molecule Cc1ccc(NC(=O)C[NH+]2CC[C@@H](C(=O)[O-])[C@@H]2C)cc1.,Cc1ccc(NC(=O)C[NH+]2CC[C@@H](C(=O)[O-])[C@@H]2C)cc1,amide
179018,Please add a amide to the molecule C[C@@H](NC(=O)c1n[nH]c(C2CC2)n1)c1ccc(Cl)c(Cl)c1.,C[C@@H](NC(=O)c1n[nH]c(C2CC2)n1)c1ccc(Cl)c(Cl)c1,amide
220372,Modify the molecule CC(C)[C@H](c1ccccc1)N(C)C(=O)CS(=O)(=O)C1CCCC1 by adding a carboxyl.,CC(C)[C@H](c1ccccc1)N(C)C(=O)CS(=O)(=O)C1CCCC1,carboxyl
126530,Add a benzene ring to the molecule CCC[NH2+][C@H](c1cccnc1)c1ccc(F)cc1F.,CCC[NH2+][C@H](c1cccnc1)c1ccc(F)cc1F,benzene ring
160766,Please add a benzene ring to the molecule CC(C)[C@H](C)N(C(=O)NCc1cn(-c2ccccc2)nn1)C1CC1.,CC(C)[C@H](C)N(C(=O)NCc1cn(-c2ccccc2)nn1)C1CC1,benzene ring
14052,Modify the molecule CCN(CC(F)(F)F)c1ccc([C@H](C)[NH2+]C)c(O)c1 by adding a benzene ring.,CCN(CC(F)(F)F)c1ccc([C@H](C)[NH2+]C)c(O)c1,benzene ring
216443,Add a benzene ring to the molecule COc1cc(F)ccc1NC(=O)c1cnn(-c2ccncc2)c1C.,COc1cc(F)ccc1NC(=O)c1cnn(-c2ccncc2)c1C,benzene ring
2208,Add a aldehyde to the molecule Cc1nc([C@@H]2CCCN(Cc3ccccc3)C2)ncc1C(=O)N1CCCCC1.,Cc1nc([C@@H]2CCCN(Cc3ccccc3)C2)ncc1C(=O)N1CCCCC1,aldehyde
2611,Modify the molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 by adding a hydroxyl.,C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1,hydroxyl
231700,Add a hydroxyl to the molecule O=C(N[C@@H]1CCc2[nH]ncc2C1)N[C@@H]1C[C@H]2CCCc3cccc1c32.,O=C(N[C@@H]1CCc2[nH]ncc2C1)N[C@@H]1C[C@H]2CCCc3cccc1c32,hydroxyl
219144,Please add a nitro to the molecule Cc1c(CNC(=O)C2C[C@H](C)O[C@@H](C)C2)oc2ccccc12.,Cc1c(CNC(=O)C2C[C@H](C)O[C@@H](C)C2)oc2ccccc12,nitro
95544,Add a hydroxyl to the molecule Cc1nc(C)c(C(=O)N2C[C@H](C)CCC[C@@H]2C)o1.,Cc1nc(C)c(C(=O)N2C[C@H](C)CCC[C@@H]2C)o1,hydroxyl
14164,Please add a benzene ring to the molecule C=CCn1c(S)nnc1-c1ccc(C)c(C)c1.,C=CCn1c(S)nnc1-c1ccc(C)c(C)c1,benzene ring
100321,Modify the molecule N#Cc1ccc(CNC[C@@H](O)c2c(F)cccc2F)cc1 by adding a amine.,N#Cc1ccc(CNC[C@@H](O)c2c(F)cccc2F)cc1,amine
4108,Please add a nitro to the molecule C[C@H]1C(=O)N(C[C@@H]2CC[C@H](C(=O)NN)O2)C(=O)[C@@H]1C.,C[C@H]1C(=O)N(C[C@@H]2CC[C@H](C(=O)NN)O2)C(=O)[C@@H]1C,nitro
103528,Modify the molecule Cc1cccc(NC(=O)CSc2nccn2-c2cccc(Cl)c2)c1 by adding a aldehyde.,Cc1cccc(NC(=O)CSc2nccn2-c2cccc(Cl)c2)c1,aldehyde
94522,Modify the molecule CCN(CC)c1ccc(C=C2C(=O)OC(c3ccccc3)OC2=O)o1 by adding a hydroxyl.,CCN(CC)c1ccc(C=C2C(=O)OC(c3ccccc3)OC2=O)o1,hydroxyl
92321,Modify the molecule CCCNC(=O)CS(=O)(=O)Cc1coc(-c2cccc(Cl)c2)n1 by adding a carboxyl.,CCCNC(=O)CS(=O)(=O)Cc1coc(-c2cccc(Cl)c2)n1,carboxyl
107058,Modify the molecule CNC(=O)[C@@H](C)CN(C)C(=O)C1=NN(c2cc(C)ccc2C)C(=O)CC1 by adding a hydroxyl.,CNC(=O)[C@@H](C)CN(C)C(=O)C1=NN(c2cc(C)ccc2C)C(=O)CC1,hydroxyl
21383,Add a benzene ring to the molecule O=C(NCCc1ccccc1)C1CCN(C(=O)c2cc3oc(-c4ccccc4)cc3[nH]2)CC1.,O=C(NCCc1ccccc1)C1CCN(C(=O)c2cc3oc(-c4ccccc4)cc3[nH]2)CC1,benzene ring
232415,Please add a halo to the molecule O=C(N/[NH+]=C\N1CCCc2ccccc21)c1ccccc1.,O=C(N/[NH+]=C\N1CCCc2ccccc21)c1ccccc1,halo
218223,Add a carboxyl to the molecule COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O.,COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O,carboxyl
215653,Please add a amide to the molecule CCc1nnc(CN2CCO[C@@H](CNc3cccn[nH+]3)C2)o1.,CCc1nnc(CN2CCO[C@@H](CNc3cccn[nH+]3)C2)o1,amide
137759,Modify the molecule Cc1cnn(C[C@@H](C)[NH2+]CC(C)(C)C)c1 by adding a nitrile.,Cc1cnn(C[C@@H](C)[NH2+]CC(C)(C)C)c1,nitrile
729,Add a hydroxyl to the molecule [NH3+][C@H](CO)c1ccc(N2CCOCC2)c(Cl)c1Cl.,[NH3+][C@H](CO)c1ccc(N2CCOCC2)c(Cl)c1Cl,hydroxyl
231523,Add a aldehyde to the molecule C=CCN1C(=O)/C(=C\NC23CC4CC(CC(C4)C2)C3)C(=O)NC1=S.,C=CCN1C(=O)/C(=C\NC23CC4CC(CC(C4)C2)C3)C(=O)NC1=S,aldehyde
87645,Please add a hydroxyl to the molecule COc1cc(Cl)c(C)cc1NC(=O)CSc1cc(=O)n(C)c2cc(Cl)ccc12.,COc1cc(Cl)c(C)cc1NC(=O)CSc1cc(=O)n(C)c2cc(Cl)ccc12,hydroxyl
108527,Modify the molecule C[C@@H](NC(=O)Cc1ccccc1[N+](=O)[O-])c1cccc(N2CCCC2)c1 by adding a hydroxyl.,C[C@@H](NC(=O)Cc1ccccc1[N+](=O)[O-])c1cccc(N2CCCC2)c1,hydroxyl
67790,Please add a aldehyde to the molecule CC[C@]1(C)Cc2nc3sc4c(=O)n(CCc5ccccc5)cnc4c3cc2CO1.,CC[C@]1(C)Cc2nc3sc4c(=O)n(CCc5ccccc5)cnc4c3cc2CO1,aldehyde
106929,Add a nitro to the molecule Cc1ccc(S(C)(=O)=O)cc1S(=O)(=O)NCC1(C)Cc2ccccc2C1.,Cc1ccc(S(C)(=O)=O)cc1S(=O)(=O)NCC1(C)Cc2ccccc2C1,nitro
181498,Modify the molecule CC(C)OC(=O)N1CCC(NC(=O)c2nc(C3CC3)n3ccccc23)CC1 by adding a amine.,CC(C)OC(=O)N1CCC(NC(=O)c2nc(C3CC3)n3ccccc23)CC1,amine
336,Add a hydroxyl to the molecule O=C(C[NH+]1CCC(C(=O)c2ccc(Cl)cc2)CC1)NC[C@H]1COCCO1.,O=C(C[NH+]1CCC(C(=O)c2ccc(Cl)cc2)CC1)NC[C@H]1COCCO1,hydroxyl
101897,Please add a carboxyl to the molecule Cc1cc(C(=O)N2CCN(C3=NS(=O)(=O)c4ccccc43)CC2)ccc1[N+](=O)[O-].,Cc1cc(C(=O)N2CCN(C3=NS(=O)(=O)c4ccccc43)CC2)ccc1[N+](=O)[O-],carboxyl
75338,Modify the molecule CS[C@@H](C)c1cccc(NC(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c1 by adding a benzene ring.,CS[C@@H](C)c1cccc(NC(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c1,benzene ring
96455,Modify the molecule C[NH+]1CCC[C@H](NC(=O)NC[C@@](C)(O)c2ccco2)C1 by adding a hydroxyl.,C[NH+]1CCC[C@H](NC(=O)NC[C@@](C)(O)c2ccco2)C1,hydroxyl
183789,Add a amide to the molecule O=C(c1ccc2nccnc2c1)N(C[C@H]1CCCO1)c1nc2ccc(Cl)cc2s1.,O=C(c1ccc2nccnc2c1)N(C[C@H]1CCCO1)c1nc2ccc(Cl)cc2s1,amide
219362,Add a hydroxyl to the molecule C=CCNC(=O)C(=O)NCC1(c2ccccc2OC)CCOCC1.,C=CCNC(=O)C(=O)NCC1(c2ccccc2OC)CCOCC1,hydroxyl
146379,Modify the molecule O=C([O-])C[C@@H](Br)C(=O)c1ccc2c(c1)CCC2 by adding a hydroxyl.,O=C([O-])C[C@@H](Br)C(=O)c1ccc2c(c1)CCC2,hydroxyl
223493,Modify the molecule C[C@H](NC[C@@](C)(O)c1ccc(F)cc1)c1ccc(NC(=O)NC2CC2)cc1 by adding a amine.,C[C@H](NC[C@@](C)(O)c1ccc(F)cc1)c1ccc(NC(=O)NC2CC2)cc1,amine
23431,Add a amine to the molecule Cc1cc(C)n(-c2cc(Cl)ccc2-c2cncnc2)n1.,Cc1cc(C)n(-c2cc(Cl)ccc2-c2cncnc2)n1,amine
38319,Modify the molecule Cc1csc(=O)n1CC(=O)Nc1ccc(N)cc1 by adding a halo.,Cc1csc(=O)n1CC(=O)Nc1ccc(N)cc1,halo
75211,Please add a benzene ring to the molecule Cc1cnc(CNC(=O)N[C@@H]2CCC[C@@H](C(=O)NC(C)C)C2)s1.,Cc1cnc(CNC(=O)N[C@@H]2CCC[C@@H](C(=O)NC(C)C)C2)s1,benzene ring
6656,Please add a benzene ring to the molecule O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1.,O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1,benzene ring
249434,Add a amide to the molecule Cn1cc(N2CCC[C@@H](NC(=O)NCCNc3ncccc3C#N)C2)cn1.,Cn1cc(N2CCC[C@@H](NC(=O)NCCNc3ncccc3C#N)C2)cn1,amide
196940,Please add a amide to the molecule Cc1ccccc1CN1CCN(CC(=O)NCc2ccco2)C1=O.,Cc1ccccc1CN1CCN(CC(=O)NCc2ccco2)C1=O,amide
34580,Modify the molecule O=S1(=O)CCC(C[NH2+][C@H]2CCc3c2ccc(Cl)c3Cl)CC1 by adding a benzene ring.,O=S1(=O)CCC(C[NH2+][C@H]2CCc3c2ccc(Cl)c3Cl)CC1,benzene ring
112750,Please add a benzene ring to the molecule Cc1oc(-c2cccs2)nc1CC(=O)N1CCNC(=O)[C@H]1C.,Cc1oc(-c2cccs2)nc1CC(=O)N1CCNC(=O)[C@H]1C,benzene ring
20826,Modify the molecule CC[C@H](C)c1noc([C@H]2C=C[C@@H]([NH3+])C2)n1 by adding a halo.,CC[C@H](C)c1noc([C@H]2C=C[C@@H]([NH3+])C2)n1,halo
99258,Please add a carboxyl to the molecule Cn1ccc(NCc2cc(=O)n(C)c(=O)n2C)n1.,Cn1ccc(NCc2cc(=O)n(C)c(=O)n2C)n1,carboxyl
96665,Add a amine to the molecule FC(F)(F)c1cc(-c2ccc(Cl)nn2)cc(C(F)(F)F)c1.,FC(F)(F)c1cc(-c2ccc(Cl)nn2)cc(C(F)(F)F)c1,amine
47314,Please add a amine to the molecule CCOc1ccc(C(=O)N(C)C)cc1NC(=O)NCC1CC[NH+](C)CC1.,CCOc1ccc(C(=O)N(C)C)cc1NC(=O)NCC1CC[NH+](C)CC1,amine
115104,Add a benzene ring to the molecule O=C([C@@H]1C[C@@H]1c1ccccc1F)N1CCCCC[C@@H]1c1ccncc1.,O=C([C@@H]1C[C@@H]1c1ccccc1F)N1CCCCC[C@@H]1c1ccncc1,benzene ring
152500,Add a benzene ring to the molecule CC(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)N(C)C)cc3[C@H]3C=CC[C@@H]32)cc1.,CC(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)N(C)C)cc3[C@H]3C=CC[C@@H]32)cc1,benzene ring
138327,Modify the molecule CSc1ccc(C[NH+]2CCC3(CC2)C(=O)N(C)C(=O)N3CC(C)C)cc1 by adding a halo.,CSc1ccc(C[NH+]2CCC3(CC2)C(=O)N(C)C(=O)N3CC(C)C)cc1,halo
50194,Please add a hydroxyl to the molecule CCNC(=O)N1CCN(Cc2ncc(Cl)n2C)CC1.,CCNC(=O)N1CCN(Cc2ncc(Cl)n2C)CC1,hydroxyl
72922,Modify the molecule O=C1NCCN1[C@@H]1CCCN(c2nc3ccccc3o2)C1 by adding a amide.,O=C1NCCN1[C@@H]1CCCN(c2nc3ccccc3o2)C1,amide
64772,Please add a amide to the molecule O=C(Nc1cccc(Cl)c1)Nc1cccc(C(F)(F)F)c1.,O=C(Nc1cccc(Cl)c1)Nc1cccc(C(F)(F)F)c1,amide
242112,Please add a carboxyl to the molecule C=CCOC(=O)c1s/c(=N\C(=O)[C@H]2Sc3cc(C)ccc3[C@H]2Cl)[nH]c1C.,C=CCOC(=O)c1s/c(=N\C(=O)[C@H]2Sc3cc(C)ccc3[C@H]2Cl)[nH]c1C,carboxyl
131621,Add a benzene ring to the molecule O=C(N/N=C/c1ccccc1Cl)c1cc(C2CC2)nc2ccccc12.,O=C(N/N=C/c1ccccc1Cl)c1cc(C2CC2)nc2ccccc12,benzene ring
30059,Modify the molecule COc1ccccc1N1CC[C@H](NC(=O)Cc2cccc(OCC#N)c2)C1 by adding a hydroxyl.,COc1ccccc1N1CC[C@H](NC(=O)Cc2cccc(OCC#N)c2)C1,hydroxyl
56584,Modify the molecule COc1ccc(OC)c([C@H](C)NC(=O)c2ccc(Cl)s2)c1 by adding a nitro.,COc1ccc(OC)c([C@H](C)NC(=O)c2ccc(Cl)s2)c1,nitro
78929,Add a nitrile to the molecule Cc1ncsc1CNC(=O)N(C)[C@H](C)Cc1cccs1.,Cc1ncsc1CNC(=O)N(C)[C@H](C)Cc1cccs1,nitrile
132639,Add a halo to the molecule CN1C(=O)C[C@H](N2CCN(C(=O)C[NH+]3CCCC3)CC2)C1=O.,CN1C(=O)C[C@H](N2CCN(C(=O)C[NH+]3CCCC3)CC2)C1=O,halo
59552,Add a hydroxyl to the molecule Cc1ccc([C@@H](C)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1F.,Cc1ccc([C@@H](C)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1F,hydroxyl
194488,Add a carboxyl to the molecule Cc1nc2ccc(NC(=O)NC[C@H]3CCCN(c4ncccn4)C3)cc2o1.,Cc1nc2ccc(NC(=O)NC[C@H]3CCCN(c4ncccn4)C3)cc2o1,carboxyl
56029,Add a amide to the molecule COc1ccc2c(c1)CCCN2C(=O)NC[C@H](C)N1CCOCC1.,COc1ccc2c(c1)CCCN2C(=O)NC[C@H](C)N1CCOCC1,amide
92598,Add a amine to the molecule OCC1(CNc2nn3cc(-c4ccc(F)cc4)nc3s2)CC1.,OCC1(CNc2nn3cc(-c4ccc(F)cc4)nc3s2)CC1,amine
151677,Add a hydroxyl to the molecule CC(C)n1ccc(C[C@@H](C(=O)[O-])c2cccc(Cl)c2)n1.,CC(C)n1ccc(C[C@@H](C(=O)[O-])c2cccc(Cl)c2)n1,hydroxyl
235193,Modify the molecule C[C@@]1(CO)CCC[C@H]1NC(=O)c1nc2ccccc2c(=O)[nH]1 by adding a amide.,C[C@@]1(CO)CCC[C@H]1NC(=O)c1nc2ccccc2c(=O)[nH]1,amide
89584,Modify the molecule O=C(N[C@H]1CCSc2c(F)cccc21)c1ccc(NS(=O)(=O)c2cccs2)cc1 by adding a halo.,O=C(N[C@H]1CCSc2c(F)cccc21)c1ccc(NS(=O)(=O)c2cccs2)cc1,halo
70350,Please add a carboxyl to the molecule Cc1c(C[NH+]2C[C@@H]3CC[C@H](C2)N(CC2CCC2)C3=O)cnn1C.,Cc1c(C[NH+]2C[C@@H]3CC[C@H](C2)N(CC2CCC2)C3=O)cnn1C,carboxyl
164852,Modify the molecule COc1ccc(-c2c(C)nn(-c3ccccc3)c2/N=C/N2CCOCC2)cc1OC by adding a hydroxyl.,COc1ccc(-c2c(C)nn(-c3ccccc3)c2/N=C/N2CCOCC2)cc1OC,hydroxyl
97914,Please add a hydroxyl to the molecule O=C(Nc1ccc(O)cc1)C(=O)Nc1nc2ccccc2s1.,O=C(Nc1ccc(O)cc1)C(=O)Nc1nc2ccccc2s1,hydroxyl
62464,Please add a hydroxyl to the molecule COC(=O)c1sccc1NC(=O)C1CCN(S(=O)(=O)c2ccc(C(C)C)cc2)CC1.,COC(=O)c1sccc1NC(=O)C1CCN(S(=O)(=O)c2ccc(C(C)C)cc2)CC1,hydroxyl
150497,Please add a carboxyl to the molecule COC(=O)c1nn(C[NH+](C)Cc2ccc(Cl)cc2)c(=O)c2noc(C)c12.,COC(=O)c1nn(C[NH+](C)Cc2ccc(Cl)cc2)c(=O)c2noc(C)c12,carboxyl
110829,Modify the molecule COc1ccc(CCCC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)cc1 by adding a hydroxyl.,COc1ccc(CCCC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)cc1,hydroxyl
154407,Add a carboxyl to the molecule Cc1nn(C)c2c1nc(N)n2C[C@H]1CC[NH+](C(C)C)C1.,Cc1nn(C)c2c1nc(N)n2C[C@H]1CC[NH+](C(C)C)C1,carboxyl
138646,Modify the molecule Cc1cccc(C)c1CN1C(=O)N[C@@](C)(c2cccs2)C1=O by adding a halo.,Cc1cccc(C)c1CN1C(=O)N[C@@](C)(c2cccs2)C1=O,halo
31179,Modify the molecule CC(C)NC(=O)CN1CCN(C(=O)N[C@H](Cn2cncn2)c2ccccc2)CC1 by adding a hydroxyl.,CC(C)NC(=O)CN1CCN(C(=O)N[C@H](Cn2cncn2)c2ccccc2)CC1,hydroxyl
100088,Add a amine to the molecule C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C.,C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C,amine
127484,Please add a hydroxyl to the molecule c1ccc(-c2nn3c(-c4cccnc4)nnc3c3ccccc23)cc1.,c1ccc(-c2nn3c(-c4cccnc4)nnc3c3ccccc23)cc1,hydroxyl
30187,Please add a carboxyl to the molecule CC[NH+]1CCCC[C@@H]1CNC(=O)CSCC(F)(F)F.,CC[NH+]1CCCC[C@@H]1CNC(=O)CSCC(F)(F)F,carboxyl
127695,Add a hydroxyl to the molecule CCSc1cncc(Sc2nnc(-c3cc4ccccc4o3)o2)n1.,CCSc1cncc(Sc2nnc(-c3cc4ccccc4o3)o2)n1,hydroxyl
58359,Please add a hydroxyl to the molecule COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1.,COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1,hydroxyl
12108,Add a benzene ring to the molecule O=C(Nc1ccc2c(c1)OCO2)C1CC[NH+]([C@@H](C(=O)Nc2ccc(F)cc2)c2ccccc2)CC1.,O=C(Nc1ccc2c(c1)OCO2)C1CC[NH+]([C@@H](C(=O)Nc2ccc(F)cc2)c2ccccc2)CC1,benzene ring
182850,Modify the molecule CC1(C)CC(=O)C(/C=N/c2ccc([N+](=O)[O-])cc2)=C([O-])C1 by adding a amide.,CC1(C)CC(=O)C(/C=N/c2ccc([N+](=O)[O-])cc2)=C([O-])C1,amide
40436,Please add a benzene ring to the molecule C[NH+](C[C@@H]1Cc2[nH+]c[nH]c2CN1)C[C@@H]1CCCO1.,C[NH+](C[C@@H]1Cc2[nH+]c[nH]c2CN1)C[C@@H]1CCCO1,benzene ring
49685,Please add a hydroxyl to the molecule COC(=O)C1(NC(=O)[C@@H]2CCCc3sccc32)CCSCC1.,COC(=O)C1(NC(=O)[C@@H]2CCCc3sccc32)CCSCC1,hydroxyl
28398,Add a aldehyde to the molecule Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2nc(C3CC3)no2)n1.,Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2nc(C3CC3)no2)n1,aldehyde
229490,Add a amine to the molecule Cc1ncccc1Oc1ccc(C[NH3+])cc1.,Cc1ncccc1Oc1ccc(C[NH3+])cc1,amine
222147,Add a hydroxyl to the molecule O=C(c1cc(Br)ccc1Cl)N1CCC(C(=O)N2CCCCC2)CC1.,O=C(c1cc(Br)ccc1Cl)N1CCC(C(=O)N2CCCCC2)CC1,hydroxyl
122082,Modify the molecule COc1ccc2oc(C(=O)OCC(=O)NC(=O)NC(C)(C)C)c(C)c2c1 by adding a amide.,COc1ccc2oc(C(=O)OCC(=O)NC(=O)NC(C)(C)C)c(C)c2c1,amide
132790,Please add a hydroxyl to the molecule CCOc1ccc2nc(SC[C@H](C)/C(N)=N/O)[nH]c2c1.,CCOc1ccc2nc(SC[C@H](C)/C(N)=N/O)[nH]c2c1,hydroxyl
202797,Modify the molecule CCCN(C/C=C/c1ccccc1)C(=O)C[C@@H]1C(=O)N=C(C)N=C1C by adding a benzene ring.,CCCN(C/C=C/c1ccccc1)C(=O)C[C@@H]1C(=O)N=C(C)N=C1C,benzene ring
232793,Modify the molecule Cc1ccc(OCC(=O)O[C@@H](C)CN2CCOCC2)cc1 by adding a benzene ring.,Cc1ccc(OCC(=O)O[C@@H](C)CN2CCOCC2)cc1,benzene ring
103499,Modify the molecule Cc1ccccc1OCCN(C)C(=O)c1cccc(S(=O)(=O)N2CCCC2)c1 by adding a amide.,Cc1ccccc1OCCN(C)C(=O)c1cccc(S(=O)(=O)N2CCCC2)c1,amide
116968,Modify the molecule Cc1noc(C)c1C[S@@](=O)[C@H](C)C(=O)NC1CCCC1 by adding a amide.,Cc1noc(C)c1C[S@@](=O)[C@H](C)C(=O)NC1CCCC1,amide
144364,Please add a benzene ring to the molecule CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F.,CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F,benzene ring
199123,Add a benzene ring to the molecule CC(C)n1ccc(C/C=C/CCCl)n1.,CC(C)n1ccc(C/C=C/CCCl)n1,benzene ring
67898,Please add a benzene ring to the molecule Cc1nn(C)c(C)c1CCC/[NH+]=C(/N)Nc1ccc2c(c1)CCC2.,Cc1nn(C)c(C)c1CCC/[NH+]=C(/N)Nc1ccc2c(c1)CCC2,benzene ring
172766,Please add a hydroxyl to the molecule O=S(=O)(/C=C/c1ccccc1)Nc1cccc(S(=O)(=O)N2CCCCC2)c1.,O=S(=O)(/C=C/c1ccccc1)Nc1cccc(S(=O)(=O)N2CCCCC2)c1,hydroxyl
114218,Add a amide to the molecule C[C@H]1C[C@H](C)CN(c2nc3c(c(=O)[nH]2)[C@@H](c2cccc([N+](=O)[O-])c2)[C@@H](C#N)C(=O)N3)C1.,C[C@H]1C[C@H](C)CN(c2nc3c(c(=O)[nH]2)[C@@H](c2cccc([N+](=O)[O-])c2)[C@@H](C#N)C(=O)N3)C1,amide
148446,Please add a benzene ring to the molecule CCOC(=O)c1ccc(N(CC2CC2)C(=O)c2cccc(=O)n2C)cc1.,CCOC(=O)c1ccc(N(CC2CC2)C(=O)c2cccc(=O)n2C)cc1,benzene ring
7949,Modify the molecule COc1ccc(-c2nc(NC(=O)c3ccc(-c4ccc(C(C)=O)cc4)o3)sc2C)cc1 by adding a benzene ring.,COc1ccc(-c2nc(NC(=O)c3ccc(-c4ccc(C(C)=O)cc4)o3)sc2C)cc1,benzene ring
19970,Modify the molecule COc1ccc2[nH]cc(CC(=O)Nc3cccc(N(C)C(C)=O)c3)c2c1 by adding a benzene ring.,COc1ccc2[nH]cc(CC(=O)Nc3cccc(N(C)C(C)=O)c3)c2c1,benzene ring
33633,Modify the molecule CCCO/N=C(/N)c1cccnc1N1CCCCC1 by adding a hydroxyl.,CCCO/N=C(/N)c1cccnc1N1CCCCC1,hydroxyl
65597,Modify the molecule N#Cc1ccc(NC(=O)N2CCCN(C(=O)c3ccsc3)CC2)cc1 by adding a thiol.,N#Cc1ccc(NC(=O)N2CCCN(C(=O)c3ccsc3)CC2)cc1,thiol
77100,Please add a amide to the molecule Cc1ccc(C(=O)N[C@@H](C(=O)/N=c2\[nH]cn[nH]2)C(C)C)cc1.,Cc1ccc(C(=O)N[C@@H](C(=O)/N=c2\[nH]cn[nH]2)C(C)C)cc1,amide
115267,Please add a hydroxyl to the molecule Cc1cccc2cc(CN(C[C@H]3CCCO3)C(=O)Nc3ccccc3Cl)c(=O)[nH]c12.,Cc1cccc2cc(CN(C[C@H]3CCCO3)C(=O)Nc3ccccc3Cl)c(=O)[nH]c12,hydroxyl
174829,Modify the molecule CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1 by adding a benzene ring.,CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1,benzene ring
121465,Modify the molecule O=C(O[C@@H](c1ccccc1)c1nccs1)[C@H]1COc2ccccc2O1 by adding a benzene ring.,O=C(O[C@@H](c1ccccc1)c1nccs1)[C@H]1COc2ccccc2O1,benzene ring
81313,Modify the molecule CCCOC(=O)N1CC[C@]2(CCC[NH+](C/C=C/c3ccco3)C2)C1 by adding a benzene ring.,CCCOC(=O)N1CC[C@]2(CCC[NH+](C/C=C/c3ccco3)C2)C1,benzene ring
174176,Please add a amine to the molecule O=C1CN([C@@H]2CCCS(=O)(=O)C2)C(=O)[C@@H]2CCCCN12.,O=C1CN([C@@H]2CCCS(=O)(=O)C2)C(=O)[C@@H]2CCCCN12,amine
125238,Add a benzene ring to the molecule COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1.,COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1,benzene ring
30697,Modify the molecule O=C(CCCc1cccs1)Nc1ccc2c(c1)OCCCO2 by adding a hydroxyl.,O=C(CCCc1cccs1)Nc1ccc2c(c1)OCCCO2,hydroxyl
110316,Please add a hydroxyl to the molecule CN(C)C(=O)Sc1ccc(COc2cccc(C(=O)N(C)C)c2)cc1.,CN(C)C(=O)Sc1ccc(COc2cccc(C(=O)N(C)C)c2)cc1,hydroxyl
206923,Add a benzene ring to the molecule C[C@H](NC(=O)c1ccc(F)cc1)[C@@H](c1cccs1)N1CCN(c2ccc(F)cc2)CC1.,C[C@H](NC(=O)c1ccc(F)cc1)[C@@H](c1cccs1)N1CCN(c2ccc(F)cc2)CC1,benzene ring
112848,Add a amine to the molecule O=C(NCc1nncn1CCc1ccccc1)c1cccc(-n2cnnc2)c1.,O=C(NCc1nncn1CCc1ccccc1)c1cccc(-n2cnnc2)c1,amine
214673,Please add a amide to the molecule Cc1cc(C)n2c(SCC(=O)c3c[nH]c(C(=O)N4CCCC4)c3)nnc2n1.,Cc1cc(C)n2c(SCC(=O)c3c[nH]c(C(=O)N4CCCC4)c3)nnc2n1,amide
83813,Add a aldehyde to the molecule CCCC(C)(C)NC(=O)c1nn(-c2ccccc2)c(C)cc1=O.,CCCC(C)(C)NC(=O)c1nn(-c2ccccc2)c(C)cc1=O,aldehyde
112580,Modify the molecule CCC[NH2+]Cc1ccnn1C[C@@H]1C[C@H]2CC[C@@H]1C2 by adding a halo.,CCC[NH2+]Cc1ccnn1C[C@@H]1C[C@H]2CC[C@@H]1C2,halo
249035,Add a benzene ring to the molecule NNc1cc(COCc2ccc(Cl)cc2)ccc1[N+](=O)[O-].,NNc1cc(COCc2ccc(Cl)cc2)ccc1[N+](=O)[O-],benzene ring
20880,Add a benzene ring to the molecule CN(Cc1nnc(C2CC2)n1C)C(=O)CCc1cccc(Cl)c1.,CN(Cc1nnc(C2CC2)n1C)C(=O)CCc1cccc(Cl)c1,benzene ring
166013,Modify the molecule Cc1c[nH]c(=O)n1-c1ccc([C@H](C)[NH2+]CCN2CCCS2(=O)=O)cc1 by adding a aldehyde.,Cc1c[nH]c(=O)n1-c1ccc([C@H](C)[NH2+]CCN2CCCS2(=O)=O)cc1,aldehyde
159654,Modify the molecule O=S1(=O)CCC[C@H]([NH2+][C@@H]2CCOC3(CCCCC3)C2)C1 by adding a aldehyde.,O=S1(=O)CCC[C@H]([NH2+][C@@H]2CCOC3(CCCCC3)C2)C1,aldehyde
81764,Please add a benzene ring to the molecule O=c1ccc(-c2ccc3c(c2)OCO3)nn1C1CCCCC1.,O=c1ccc(-c2ccc3c(c2)OCO3)nn1C1CCCCC1,benzene ring
166916,Please add a nitro to the molecule C[C@H]([NH2+]Cc1cccs1)c1ccncc1.,C[C@H]([NH2+]Cc1cccs1)c1ccncc1,nitro
100399,Please add a nitrile to the molecule COc1ccc(NC(C)=O)cc1NC(=O)N[C@H](c1cccs1)C(C)C.,COc1ccc(NC(C)=O)cc1NC(=O)N[C@H](c1cccs1)C(C)C,nitrile
14431,Modify the molecule Cc1cc(S(=O)(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)sc1C by adding a amide.,Cc1cc(S(=O)(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)sc1C,amide
192639,Modify the molecule Cc1cc2c(-c3ccccc3F)nc(Cl)nc2s1 by adding a benzene ring.,Cc1cc2c(-c3ccccc3F)nc(Cl)nc2s1,benzene ring
202862,Modify the molecule CC[NH2+][C@]1(C(N)=O)CCC[C@H]1CCn1nc(C)c(Cl)c1C by adding a carboxyl.,CC[NH2+][C@]1(C(N)=O)CCC[C@H]1CCn1nc(C)c(Cl)c1C,carboxyl
244687,Please add a amine to the molecule Cc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)cc1F.,Cc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)cc1F,amine
174617,Add a halo to the molecule Cc1ccc(C[NH2+][C@H]2CCC[C@H](S(C)(=O)=O)C2)cc1F.,Cc1ccc(C[NH2+][C@H]2CCC[C@H](S(C)(=O)=O)C2)cc1F,halo
188062,Modify the molecule CCc1noc([C@@H](C)[NH+]2CCC(CO)CC2)n1 by adding a amine.,CCc1noc([C@@H](C)[NH+]2CCC(CO)CC2)n1,amine
134306,Please add a amide to the molecule Cc1ccc(CNC(=O)N2CCN(c3ccccc3Cl)CC2)s1.,Cc1ccc(CNC(=O)N2CCN(c3ccccc3Cl)CC2)s1,amide
220569,Please add a hydroxyl to the molecule CC(C)C[C@@H](CNc1ncc(C(=O)N2CCCCC2)cc1Cl)[NH+](C)C.,CC(C)C[C@@H](CNc1ncc(C(=O)N2CCCCC2)cc1Cl)[NH+](C)C,hydroxyl
158822,Modify the molecule Cc1nnc(SCC(=O)N[C@@H](C)c2ccco2)n1Cc1ccccc1 by adding a hydroxyl.,Cc1nnc(SCC(=O)N[C@@H](C)c2ccco2)n1Cc1ccccc1,hydroxyl
3921,Add a benzene ring to the molecule O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1.,O=C1[C@H]2CN(c3nccc4nc(C(F)(F)F)ccc34)CCN2C(=O)N1CCc1ccccc1,benzene ring
48774,Add a hydroxyl to the molecule COc1ncnc(N2CCC[C@H]2C2CCCC2)c1N.,COc1ncnc(N2CCC[C@H]2C2CCCC2)c1N,hydroxyl
99626,Modify the molecule CCCn1ccn(CN2CCN(S(=O)(=O)c3ccc(F)c(F)c3F)CC2)c1=S by adding a benzene ring.,CCCn1ccn(CN2CCN(S(=O)(=O)c3ccc(F)c(F)c3F)CC2)c1=S,benzene ring
72116,Add a amide to the molecule COc1cc([N+](=O)[O-])ccc1NC(=O)C1CCN(C(=O)Nc2cccs2)CC1.,COc1cc([N+](=O)[O-])ccc1NC(=O)C1CCN(C(=O)Nc2cccs2)CC1,amide
12926,Please add a carboxyl to the molecule CCOC(=O)[C@]1(C#N)C(N)=C(C#N)C2=C(CCCC2)[C@H]1c1ccccc1.,CCOC(=O)[C@]1(C#N)C(N)=C(C#N)C2=C(CCCC2)[C@H]1c1ccccc1,carboxyl
100166,Please add a benzene ring to the molecule CCOc1ccc(S(=O)(=O)NCC2CCN(C(=O)OC)CC2)cc1.,CCOc1ccc(S(=O)(=O)NCC2CCN(C(=O)OC)CC2)cc1,benzene ring
5814,Add a hydroxyl to the molecule C[C@@H]1C[C@@H](O)[C@@]2(C)C(C(=O)[O-])=CCC[C@@H]2[C@@]1(C)CCC1=C[C@H](O)OC1=O.,C[C@@H]1C[C@@H](O)[C@@]2(C)C(C(=O)[O-])=CCC[C@@H]2[C@@]1(C)CCC1=C[C@H](O)OC1=O,hydroxyl
11048,Modify the molecule Cc1cccn2cc(C(N)=O)nc12 by adding a amine.,Cc1cccn2cc(C(N)=O)nc12,amine
11082,Modify the molecule Cc1[nH+]ccn1CCCC(=O)N1CSC[C@H]1C(=O)Nc1ccc(C#N)cc1 by adding a amine.,Cc1[nH+]ccn1CCCC(=O)N1CSC[C@H]1C(=O)Nc1ccc(C#N)cc1,amine
184416,Please add a amide to the molecule CCOC(=O)CN1C[C@@H]1C(=O)OCC.,CCOC(=O)CN1C[C@@H]1C(=O)OCC,amide
215321,Modify the molecule O=C(c1cccc(F)c1)N1CCN(c2cccc([N+](=O)[O-])c2)CC1 by adding a amide.,O=C(c1cccc(F)c1)N1CCN(c2cccc([N+](=O)[O-])c2)CC1,amide
52099,Modify the molecule N#CCNC(=O)C[NH+]1CCCC[C@H]1[C@@H]1CCCC1=O by adding a amide.,N#CCNC(=O)C[NH+]1CCCC[C@H]1[C@@H]1CCCC1=O,amide
207794,Modify the molecule Cc1cc(NC(=O)CCOC2CCOCC2)ncc1Br by adding a halo.,Cc1cc(NC(=O)CCOC2CCOCC2)ncc1Br,halo
69761,Add a amide to the molecule CC(=O)Nc1cccc(-n2cnn(CN3CCO[C@H]4CCCC[C@@H]43)c2=S)c1.,CC(=O)Nc1cccc(-n2cnn(CN3CCO[C@H]4CCCC[C@@H]43)c2=S)c1,amide
247852,Add a hydroxyl to the molecule O=C(N/N=C/c1cccc([N+](=O)[O-])c1)c1nc2ccccc2s1.,O=C(N/N=C/c1cccc([N+](=O)[O-])c1)c1nc2ccccc2s1,hydroxyl
221810,Add a aldehyde to the molecule Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(C)C)cc1.,Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(C)C)cc1,aldehyde
133775,Modify the molecule C[C@@H](OC(=O)C1=NC=C(Br)C1)C(=O)C1=c2ccccc2=[NH+]C1 by adding a benzene ring.,C[C@@H](OC(=O)C1=NC=C(Br)C1)C(=O)C1=c2ccccc2=[NH+]C1,benzene ring
178435,Modify the molecule COC1CC[NH+](CCNC(=O)c2ccc3c(c2)CCN3C(C)=O)CC1 by adding a hydroxyl.,COC1CC[NH+](CCNC(=O)c2ccc3c(c2)CCN3C(C)=O)CC1,hydroxyl
236010,Add a hydroxyl to the molecule Cc1ccc(C)c([C@H](O)CN2CCN(CC(=O)NC(C)C)CC2)c1.,Cc1ccc(C)c([C@H](O)CN2CCN(CC(=O)NC(C)C)CC2)c1,hydroxyl
3872,Add a halo to the molecule Clc1ncccc1OCc1coc(-c2cccs2)n1.,Clc1ncccc1OCc1coc(-c2cccs2)n1,halo
58332,Add a benzene ring to the molecule COc1ccc(-c2[nH]nc3nc(-c4ccc(C(F)(F)F)cc4)cc(C(=O)[O-])c23)cc1.,COc1ccc(-c2[nH]nc3nc(-c4ccc(C(F)(F)F)cc4)cc(C(=O)[O-])c23)cc1,benzene ring
32047,Modify the molecule COc1cc(C)ccc1NC(=O)C(=O)NCCc1ccccn1 by adding a benzene ring.,COc1cc(C)ccc1NC(=O)C(=O)NCCc1ccccn1,benzene ring
120554,Add a amine to the molecule O=C([O-])[C@@H]1CS[C@H](c2ncc(-c3ccccc3)s2)N1.,O=C([O-])[C@@H]1CS[C@H](c2ncc(-c3ccccc3)s2)N1,amine
159764,Please add a hydroxyl to the molecule Cc1c(C(=O)N(C)CC(F)(F)F)nnn1-c1ccccc1Cl.,Cc1c(C(=O)N(C)CC(F)(F)F)nnn1-c1ccccc1Cl,hydroxyl
72052,Add a amine to the molecule C[C@H]1CN(C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)C[C@@H](C)O1.,C[C@H]1CN(C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)C[C@@H](C)O1,amine
118337,Please add a hydroxyl to the molecule Cc1csc([C@H](C#N)C(=O)[C@H]2Cc3ccccc3S2)n1.,Cc1csc([C@H](C#N)C(=O)[C@H]2Cc3ccccc3S2)n1,hydroxyl
175207,Add a nitro to the molecule COCCCNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCC1.,COCCCNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCC1,nitro
79341,Add a nitro to the molecule CS(=O)(=O)c1ccc(C(=O)Nc2ccccc2SCC(F)(F)F)cc1.,CS(=O)(=O)c1ccc(C(=O)Nc2ccccc2SCC(F)(F)F)cc1,nitro
169138,Add a hydroxyl to the molecule CC[C@H](NC(=O)COc1ccc(Cl)cc1Br)c1ccccc1.,CC[C@H](NC(=O)COc1ccc(Cl)cc1Br)c1ccccc1,hydroxyl
4405,Add a benzene ring to the molecule CC(C)OC(=O)c1cccc(-c2ccc([C@H]3[NH2+][C@H](C(=O)[O-])C(C)(C)S3)o2)c1.,CC(C)OC(=O)c1cccc(-c2ccc([C@H]3[NH2+][C@H](C(=O)[O-])C(C)(C)S3)o2)c1,benzene ring
120095,Please add a amine to the molecule Nc1cccc2c(Cl)ccnc12.,Nc1cccc2c(Cl)ccnc12,amine
244107,Modify the molecule Cc1ccc(NC(=O)c2oc3c(c2C)/C(=N/NS(=O)(=O)c2ccccc2)CCC3)cc1 by adding a carboxyl.,Cc1ccc(NC(=O)c2oc3c(c2C)/C(=N/NS(=O)(=O)c2ccccc2)CCC3)cc1,carboxyl
157429,Please add a amine to the molecule CC(C)(C)c1cnc(S[C@@H]2CCCC[C@H]2O)o1.,CC(C)(C)c1cnc(S[C@@H]2CCCC[C@H]2O)o1,amine
78467,Modify the molecule CC(C)[NH+]1CCC([NH+](C)CC2CC[NH+](CCc3cccc(F)c3)CC2)CC1 by adding a amide.,CC(C)[NH+]1CCC([NH+](C)CC2CC[NH+](CCc3cccc(F)c3)CC2)CC1,amide
34078,Modify the molecule Cc1ccc(-n2nnnc2SCC(=O)Nc2ccccc2[N+](=O)[O-])cc1 by adding a hydroxyl.,Cc1ccc(-n2nnnc2SCC(=O)Nc2ccccc2[N+](=O)[O-])cc1,hydroxyl
5674,Add a benzene ring to the molecule Cc1nnsc1C(=O)N1CCC[C@H](c2nnc(-c3ccccc3F)s2)C1.,Cc1nnsc1C(=O)N1CCC[C@H](c2nnc(-c3ccccc3F)s2)C1,benzene ring
165440,Please add a amide to the molecule Cc1ccc(S(=O)(=O)NC2CC2)cc1C(=O)Nc1ccc2c(c1)COC2.,Cc1ccc(S(=O)(=O)NC2CC2)cc1C(=O)Nc1ccc2c(c1)COC2,amide
218925,Please add a nitro to the molecule C[C@H](C(=O)[O-])N1C(=O)C[C@@H](N2C(=O)/C(=C/c3ccccc3)SC2=S)C1=O.,C[C@H](C(=O)[O-])N1C(=O)C[C@@H](N2C(=O)/C(=C/c3ccccc3)SC2=S)C1=O,nitro
65733,Please add a benzene ring to the molecule OCCC[NH+]1CCN(c2ccccc2)CC1.,OCCC[NH+]1CCN(c2ccccc2)CC1,benzene ring
192269,Modify the molecule CC1(C)C[C@H]1C(=O)NC[C@@H]1C[C@H](O)C[NH+]1Cc1ccccc1 by adding a benzene ring.,CC1(C)C[C@H]1C(=O)NC[C@@H]1C[C@H](O)C[NH+]1Cc1ccccc1,benzene ring
134310,Please add a benzene ring to the molecule COCc1ccccc1/C([O-])=N/S(=O)(=O)c1ccc2ccccc2c1.,COCc1ccccc1/C([O-])=N/S(=O)(=O)c1ccc2ccccc2c1,benzene ring
84714,Modify the molecule CC1(C)C(C[NH2+]C[C@]2(C)CCC[NH2+]C2)C1(C)C by adding a carboxyl.,CC1(C)C(C[NH2+]C[C@]2(C)CCC[NH2+]C2)C1(C)C,carboxyl
37154,Add a amide to the molecule COc1cc(C=O)c([N+](=O)[O-])cc1OC[C@H]1CCCO1.,COc1cc(C=O)c([N+](=O)[O-])cc1OC[C@H]1CCCO1,amide
91271,Add a amide to the molecule CC(C)OC[C@@H](O)CI.,CC(C)OC[C@@H](O)CI,amide
12446,Modify the molecule COC(=O)Nc1nc(CC(=O)Nc2ccc3c(c2)OCCO3)cs1 by adding a hydroxyl.,COC(=O)Nc1nc(CC(=O)Nc2ccc3c(c2)OCCO3)cs1,hydroxyl
183536,Add a benzene ring to the molecule C=CCOc1cccc(/C=N/NC(=O)Cn2c3ccccc3c(=O)c3ccccc32)c1.,C=CCOc1cccc(/C=N/NC(=O)Cn2c3ccccc3c(=O)c3ccccc32)c1,benzene ring
204012,Please add a benzene ring to the molecule C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1.,C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1,benzene ring
52487,Please add a amide to the molecule Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2.,Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2,amide
38824,Add a aldehyde to the molecule O=C([C@H]1CC(=O)N(c2ccc(Cl)cc2)C1)N1CC(c2nc(-c3ncccn3)no2)C1.,O=C([C@H]1CC(=O)N(c2ccc(Cl)cc2)C1)N1CC(c2nc(-c3ncccn3)no2)C1,aldehyde
91668,Add a benzene ring to the molecule CC1CC[NH+](C[C@@H](O)Cn2c(C(F)(F)F)nc3ccccc32)CC1.,CC1CC[NH+](C[C@@H](O)Cn2c(C(F)(F)F)nc3ccccc32)CC1,benzene ring
92027,Modify the molecule O=C(c1ccc(OCC2CC2)cc1)N1CC(O)C1 by adding a amide.,O=C(c1ccc(OCC2CC2)cc1)N1CC(O)C1,amide
111698,Add a nitro to the molecule CN(c1ccccc1)S(=O)(=O)c1cccc(NC(=O)c2ccc(-c3cnco3)cc2)c1.,CN(c1ccccc1)S(=O)(=O)c1cccc(NC(=O)c2ccc(-c3cnco3)cc2)c1,nitro
58292,Add a benzene ring to the molecule CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1.,CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1,benzene ring
215884,Please add a hydroxyl to the molecule C[C@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)[C@@H]2CSC(=O)N2)C1.,C[C@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)[C@@H]2CSC(=O)N2)C1,hydroxyl
224014,Modify the molecule COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1 by adding a amide.,COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1,amide
228926,Please add a benzene ring to the molecule Clc1ccccc1-c1noc(OCc2cccnc2)n1.,Clc1ccccc1-c1noc(OCc2cccnc2)n1,benzene ring
151446,Please add a halo to the molecule CCOc1ncnc(Nc2ccc3c(c2)OCO3)c1[N+](=O)[O-].,CCOc1ncnc(Nc2ccc3c(c2)OCO3)c1[N+](=O)[O-],halo
97146,Please add a benzene ring to the molecule O=C(Nc1nccs1)[C@@H]1CCC[NH+]1Cc1ccc(F)c(C(F)(F)F)c1.,O=C(Nc1nccs1)[C@@H]1CCC[NH+]1Cc1ccc(F)c(C(F)(F)F)c1,benzene ring
40768,Please add a carboxyl to the molecule COc1ncccc1C(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F.,COc1ncccc1C(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F,carboxyl
80750,Add a benzene ring to the molecule Cc1csc(SCc2ccc(C(=O)NCc3ccc4c(c3)OCO4)cc2)n1.,Cc1csc(SCc2ccc(C(=O)NCc3ccc4c(c3)OCO4)cc2)n1,benzene ring
51001,Add a hydroxyl to the molecule C#CCN(CC(=O)[O-])C(=O)NCc1ccnc(C)n1.,C#CCN(CC(=O)[O-])C(=O)NCc1ccnc(C)n1,hydroxyl
38313,Add a halo to the molecule O=C(Nc1ccc(OC(F)F)c(F)c1)C(=O)N1CCC2(CCCCC2)C1.,O=C(Nc1ccc(OC(F)F)c(F)c1)C(=O)N1CCC2(CCCCC2)C1,halo
169272,Modify the molecule O=C1O[C@@H]2C=C[C@@H]3OC(=O)[C@@H]4C=C[C@H]1C4C32 by adding a amine.,O=C1O[C@@H]2C=C[C@@H]3OC(=O)[C@@H]4C=C[C@H]1C4C32,amine
5325,Add a amide to the molecule CC[C@@H](C)[C@H](C)NC(=O)Nc1ccccc1-n1nc(C)nc1C.,CC[C@@H](C)[C@H](C)NC(=O)Nc1ccccc1-n1nc(C)nc1C,amide
160139,Add a carboxyl to the molecule NNC(=O)c1cccc(-c2nc3cc(Cl)ccc3o2)c1.,NNC(=O)c1cccc(-c2nc3cc(Cl)ccc3o2)c1,carboxyl
180481,Add a aldehyde to the molecule NC(=O)COc1ccc(NCc2cc(Cl)cs2)cc1.,NC(=O)COc1ccc(NCc2cc(Cl)cs2)cc1,aldehyde
191348,Please add a hydroxyl to the molecule COc1ccccc1CCC(=O)N1C[C@H]2CC[C@@H]1CN(S(C)(=O)=O)C2.,COc1ccccc1CCC(=O)N1C[C@H]2CC[C@@H]1CN(S(C)(=O)=O)C2,hydroxyl
175515,Please add a benzene ring to the molecule CN(C)c1ccc(C(=O)N2CCC[C@@H]2c2ncc3c(n2)CC[NH2+]C3)cc1.,CN(C)c1ccc(C(=O)N2CCC[C@@H]2c2ncc3c(n2)CC[NH2+]C3)cc1,benzene ring
62559,Add a carboxyl to the molecule CC(C)=CC(=O)Nc1ccc(C(=O)[O-])cc1.,CC(C)=CC(=O)Nc1ccc(C(=O)[O-])cc1,carboxyl
174192,Please add a hydroxyl to the molecule Cc1cc(C)cc(-n2c(S[C@@H](C)C#N)nc3ccccc3c2=O)c1.,Cc1cc(C)cc(-n2c(S[C@@H](C)C#N)nc3ccccc3c2=O)c1,hydroxyl
61092,Add a carboxyl to the molecule COc1nccnc1N1CCC2(CC1)c1[nH+]c[nH]c1CCN2CC(C)C.,COc1nccnc1N1CCC2(CC1)c1[nH+]c[nH]c1CCN2CC(C)C,carboxyl
88627,Modify the molecule Cc1n[nH]c(-c2ccc(NC(=O)C(=O)NC[C@@H](C)[NH+](C)C3CC3)cc2)n1 by adding a hydroxyl.,Cc1n[nH]c(-c2ccc(NC(=O)C(=O)NC[C@@H](C)[NH+](C)C3CC3)cc2)n1,hydroxyl
169939,Add a halo to the molecule O=C(Cn1cc(C(F)(F)F)ccc1=O)NCCc1ccc(Cl)cc1.,O=C(Cn1cc(C(F)(F)F)ccc1=O)NCCc1ccc(Cl)cc1,halo
177407,Modify the molecule CN1C(=O)[C@]2(c3cc(F)ccc31)N(C)C[C@@H](c1ccco1)[C@@]21SC(=S)N(Cc2ccco2)C1=O by adding a thiol.,CN1C(=O)[C@]2(c3cc(F)ccc31)N(C)C[C@@H](c1ccco1)[C@@]21SC(=S)N(Cc2ccco2)C1=O,thiol
102401,Modify the molecule CCNc1ccnc(N2CCC([C@@H](O)c3ccccn3)CC2)n1 by adding a nitro.,CCNc1ccnc(N2CCC([C@@H](O)c3ccccn3)CC2)n1,nitro
9180,Modify the molecule CC[C@H]1N[C@]2(C(=O)N(Cc3ccccc3)c3ccccc32)[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]12 by adding a amine.,CC[C@H]1N[C@]2(C(=O)N(Cc3ccccc3)c3ccccc32)[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]12,amine
209495,Modify the molecule CN(C(=O)COC1CCCCC1)c1cccc2ncccc12 by adding a nitro.,CN(C(=O)COC1CCCCC1)c1cccc2ncccc12,nitro
103245,Add a amide to the molecule Cc1ccc(N2C[C@@H](C(=O)N3CCC[C@@H](c4nn(C)c(=O)n4-c4ccccc4)C3)CC2=O)cc1.,Cc1ccc(N2C[C@@H](C(=O)N3CCC[C@@H](c4nn(C)c(=O)n4-c4ccccc4)C3)CC2=O)cc1,amide
53907,Modify the molecule CN(C[C@H](O)C1CC1)C(=O)[C@@H]1CSCN1C(=O)c1ccc(Cl)cc1 by adding a carboxyl.,CN(C[C@H](O)C1CC1)C(=O)[C@@H]1CSCN1C(=O)c1ccc(Cl)cc1,carboxyl
6727,Add a amine to the molecule Cc1nc(SCC(=O)N(C)Cc2cnn(Cc3ccccc3)c2)c2c(C)c(C)sc2n1.,Cc1nc(SCC(=O)N(C)Cc2cnn(Cc3ccccc3)c2)c2c(C)c(C)sc2n1,amine
164338,Modify the molecule O=C(CCS(=O)(=O)c1ccc(Cl)cc1)NCCc1ccc(F)cc1 by adding a hydroxyl.,O=C(CCS(=O)(=O)c1ccc(Cl)cc1)NCCc1ccc(F)cc1,hydroxyl
150516,Modify the molecule CCn1c(CN[C@H](CC(C)C)C(=O)NC)nc2ccccc21 by adding a hydroxyl.,CCn1c(CN[C@H](CC(C)C)C(=O)NC)nc2ccccc21,hydroxyl
162685,Please add a benzene ring to the molecule O=C(C[C@H](c1cccs1)n1cccc1)NCc1cccnc1.,O=C(C[C@H](c1cccs1)n1cccc1)NCc1cccnc1,benzene ring
126009,Add a nitrile to the molecule CC(C)(C)CCN1CC[NH2+]CC1=O.,CC(C)(C)CCN1CC[NH2+]CC1=O,nitrile
31860,Please add a benzene ring to the molecule O=C(Cc1cc(F)ccc1F)N1CC[C@@H](Cc2ccccc2)C1.,O=C(Cc1cc(F)ccc1F)N1CC[C@@H](Cc2ccccc2)C1,benzene ring
30825,Modify the molecule Fc1ccc(-c2cc(-c3nnc4sc(-c5ccccc5)nn34)[nH]n2)cc1 by adding a thiol.,Fc1ccc(-c2cc(-c3nnc4sc(-c5ccccc5)nn34)[nH]n2)cc1,thiol
132018,Please add a benzene ring to the molecule Cc1cccn2cc(CC(=O)N3CCC[C@@H](n4cc[nH+]c4C)C3)nc12.,Cc1cccn2cc(CC(=O)N3CCC[C@@H](n4cc[nH+]c4C)C3)nc12,benzene ring
202922,Modify the molecule COc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NC2CCCCC2)cc1C by adding a benzene ring.,COc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NC2CCCCC2)cc1C,benzene ring
85096,Add a benzene ring to the molecule O=C(NCCO)c1ccc(Oc2nnc(-c3ccccc3)s2)cc1.,O=C(NCCO)c1ccc(Oc2nnc(-c3ccccc3)s2)cc1,benzene ring
229046,Add a nitro to the molecule CCSc1sccc1[C@@H]1C(C#N)=C(N)N(c2cccnc2)C2=C1C(=O)C[C@@H](c1ccccc1)C2.,CCSc1sccc1[C@@H]1C(C#N)=C(N)N(c2cccnc2)C2=C1C(=O)C[C@@H](c1ccccc1)C2,nitro
13141,Add a aldehyde to the molecule CN1CCN(C(=O)CSc2ccc(Cl)cc2)CC1.,CN1CCN(C(=O)CSc2ccc(Cl)cc2)CC1,aldehyde
235817,Please add a halo to the molecule C[C@@H](CC(=O)NC[C@@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccc(F)c1.,C[C@@H](CC(=O)NC[C@@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccc(F)c1,halo
148132,Modify the molecule Cc1cc(=O)oc2cc(OCC(=O)N3CCN(CC(=O)N4CCCC4)CC3)ccc12 by adding a benzene ring.,Cc1cc(=O)oc2cc(OCC(=O)N3CCN(CC(=O)N4CCCC4)CC3)ccc12,benzene ring
186448,Please add a hydroxyl to the molecule COc1ccc(N(CC(=O)NC2CC[NH+](C)CC2)S(C)(=O)=O)cc1.,COc1ccc(N(CC(=O)NC2CC[NH+](C)CC2)S(C)(=O)=O)cc1,hydroxyl
110056,Add a hydroxyl to the molecule Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1.,Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1,hydroxyl
196475,Modify the molecule CCNC(=O)NC(=O)[C@H](C)Nc1ccc2c(c1)CCN2C(C)=O by adding a hydroxyl.,CCNC(=O)NC(=O)[C@H](C)Nc1ccc2c(c1)CCN2C(C)=O,hydroxyl
163445,Please add a amine to the molecule COc1cc2c(oc(=O)c3cc(C)cc(OC)c32)c2c([C@H]3O[C@@H](C)[C@@H](O)[C@](C)(O)[C@H]3O)ccc(O)c12.,COc1cc2c(oc(=O)c3cc(C)cc(OC)c32)c2c([C@H]3O[C@@H](C)[C@@H](O)[C@](C)(O)[C@H]3O)ccc(O)c12,amine
1222,Add a carboxyl to the molecule c1ccc(-c2csc3ncnc(Nc4ccc5c(c4)OCCO5)c23)cc1.,c1ccc(-c2csc3ncnc(Nc4ccc5c(c4)OCCO5)c23)cc1,carboxyl
225430,Add a halo to the molecule COC(=O)c1ccc2c(c1)CCN2C(=O)c1ccn(-c2cccc(F)c2)n1.,COC(=O)c1ccc2c(c1)CCN2C(=O)c1ccn(-c2cccc(F)c2)n1,halo
28110,Modify the molecule O=Cc1ccc(-c2cccc(C(=O)NC3CC3)c2)cc1O by adding a benzene ring.,O=Cc1ccc(-c2cccc(C(=O)NC3CC3)c2)cc1O,benzene ring
72762,Please add a amine to the molecule Cc1ccc(S(=O)(=O)[C@@H](C)C(=O)Nc2ccccc2C(F)(F)F)cc1.,Cc1ccc(S(=O)(=O)[C@@H](C)C(=O)Nc2ccccc2C(F)(F)F)cc1,amine
128940,Add a aldehyde to the molecule O=C(COC(=O)Cn1[nH]c(=O)c2ccccc2c1=O)NCc1ccco1.,O=C(COC(=O)Cn1[nH]c(=O)c2ccccc2c1=O)NCc1ccco1,aldehyde
67848,Please add a amide to the molecule CC(C)[C@@H]([NH3+])[C@H](C)c1ccc(F)cc1.,CC(C)[C@@H]([NH3+])[C@H](C)c1ccc(F)cc1,amide
235245,Modify the molecule CCc1nnc(NC(=O)c2nn(C)c3c2CS(=O)(=O)CC3)s1 by adding a carboxyl.,CCc1nnc(NC(=O)c2nn(C)c3c2CS(=O)(=O)CC3)s1,carboxyl
16313,Add a benzene ring to the molecule CC(=O)c1ccc(N2CCN(CC(=O)N3CCNC3=O)CC2)c(F)c1.,CC(=O)c1ccc(N2CCN(CC(=O)N3CCNC3=O)CC2)c(F)c1,benzene ring
100255,Please add a hydroxyl to the molecule C[C@H](Cc1nnc(SCC(=O)c2ccc(F)cc2)o1)c1ccccc1.,C[C@H](Cc1nnc(SCC(=O)c2ccc(F)cc2)o1)c1ccccc1,hydroxyl
195095,Modify the molecule CCOc1ccccc1C(=O)N(C)[C@@H](C)c1ccccc1F by adding a halo.,CCOc1ccccc1C(=O)N(C)[C@@H](C)c1ccccc1F,halo
81389,Modify the molecule CNC(=O)c1ccc(CS(=O)(=O)c2nccn2-c2cccc(Cl)c2)cc1 by adding a hydroxyl.,CNC(=O)c1ccc(CS(=O)(=O)c2nccn2-c2cccc(Cl)c2)cc1,hydroxyl
94403,Please add a hydroxyl to the molecule Cc1cc(C(=O)c2ccccc2Cl)c(F)cc1F.,Cc1cc(C(=O)c2ccccc2Cl)c(F)cc1F,hydroxyl
106708,Please add a nitro to the molecule CC(C)CCCNC(=O)C(=O)Nc1ccc(N(C)C)nc1.,CC(C)CCCNC(=O)C(=O)Nc1ccc(N(C)C)nc1,nitro
111278,Add a amine to the molecule Cc1cc(C(=O)N[C@@H](C)c2ccc(C)c(C)c2)c(C)o1.,Cc1cc(C(=O)N[C@@H](C)c2ccc(C)c(C)c2)c(C)o1,amine
195778,Add a halo to the molecule CC(C)c1ccc(C(=O)/N=C2/N=N[C@@H](c3ccco3)S2)cc1.,CC(C)c1ccc(C(=O)/N=C2/N=N[C@@H](c3ccco3)S2)cc1,halo
89297,Modify the molecule C#C[C@H](C)OC(=O)[C@H](C)c1ccc(OC)c(OC)c1 by adding a amine.,C#C[C@H](C)OC(=O)[C@H](C)c1ccc(OC)c(OC)c1,amine
196548,Add a benzene ring to the molecule CC(=O)Nc1ccccc1OCC(=O)N1CCN(C(=O)c2cccs2)CC1.,CC(=O)Nc1ccccc1OCC(=O)N1CCN(C(=O)c2cccs2)CC1,benzene ring
140912,Add a benzene ring to the molecule OCCN1CC[NH+](C2CCN(C3CCCCCC3)CC2)CC1.,OCCN1CC[NH+](C2CCN(C3CCCCCC3)CC2)CC1,benzene ring
41316,Modify the molecule CCOc1ccc(C(=O)NC(=S)Nc2ccc(C)c(C)c2)cc1[N+](=O)[O-] by adding a carboxyl.,CCOc1ccc(C(=O)NC(=S)Nc2ccc(C)c(C)c2)cc1[N+](=O)[O-],carboxyl
133539,Please add a aldehyde to the molecule CN([C@@H]1CC[NH2+]C1)[C@@H]1CCC[C@H](S(C)(=O)=O)C1.,CN([C@@H]1CC[NH2+]C1)[C@@H]1CCC[C@H](S(C)(=O)=O)C1,aldehyde
76411,Add a benzene ring to the molecule Cc1cc(C)nc(N/C(=N/C(=O)c2cccs2)[N-]CCc2c[nH]c3ccccc23)n1.,Cc1cc(C)nc(N/C(=N/C(=O)c2cccs2)[N-]CCc2c[nH]c3ccccc23)n1,benzene ring
26925,Modify the molecule Cc1cccc(OC[C@H](O)CN2C(=O)N[C@](C)(c3ccc(C(F)(F)F)cc3)C2=O)c1 by adding a amide.,Cc1cccc(OC[C@H](O)CN2C(=O)N[C@](C)(c3ccc(C(F)(F)F)cc3)C2=O)c1,amide
5562,Add a nitrile to the molecule CC[C@@H](NC(=O)Nc1ccc(C(=O)N(C)C)c(C)c1)c1ccc(C)c(F)c1.,CC[C@@H](NC(=O)Nc1ccc(C(=O)N(C)C)c(C)c1)c1ccc(C)c(F)c1,nitrile
40363,Please add a carboxyl to the molecule CCOC(OCC)[C@@H](O)[C@H]1CCCC[C@@H]1CC.,CCOC(OCC)[C@@H](O)[C@H]1CCCC[C@@H]1CC,carboxyl
88361,Modify the molecule [NH3+]C[C@@H]1CN(C(=O)N2CCCCC2)CCO1 by adding a benzene ring.,[NH3+]C[C@@H]1CN(C(=O)N2CCCCC2)CCO1,benzene ring
156859,Please add a amine to the molecule C[C@H](Oc1ccc(/C=C\C(=O)c2ccccc2)cc1)C(=O)[O-].,C[C@H](Oc1ccc(/C=C\C(=O)c2ccccc2)cc1)C(=O)[O-],amine
192683,Please add a benzene ring to the molecule CCc1nc2n(n1)CCC[C@H]2NC(=O)c1cc(S(N)(=O)=O)ccc1F.,CCc1nc2n(n1)CCC[C@H]2NC(=O)c1cc(S(N)(=O)=O)ccc1F,benzene ring
231970,Add a aldehyde to the molecule O=C1[C@@H]2CN[C@@]3(C(=O)Nc4ccccc43)[C@H]2C(=O)N1C1CCCCC1.,O=C1[C@@H]2CN[C@@]3(C(=O)Nc4ccccc43)[C@H]2C(=O)N1C1CCCCC1,aldehyde
108483,Modify the molecule O=C(COc1ccc2ccccc2c1Br)NC[C@H]1CCCO1 by adding a benzene ring.,O=C(COc1ccc2ccccc2c1Br)NC[C@H]1CCCO1,benzene ring
86893,Modify the molecule CC(C)C[C@H](C)N(c1ccc2[nH]ccc2c1)S(=O)(=O)Cc1cccc(C#N)c1 by adding a hydroxyl.,CC(C)C[C@H](C)N(c1ccc2[nH]ccc2c1)S(=O)(=O)Cc1cccc(C#N)c1,hydroxyl
72335,Add a aldehyde to the molecule Cc1c(C(=O)OCC(=O)c2cccc(Cl)c2)cccc1[N+](=O)[O-].,Cc1c(C(=O)OCC(=O)c2cccc(Cl)c2)cccc1[N+](=O)[O-],aldehyde
1100,Please add a benzene ring to the molecule Cc1cccc(O[C@H](C)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1.,Cc1cccc(O[C@H](C)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1,benzene ring
81946,Please add a aldehyde to the molecule O=C(NCC[C@@H]1CCCO1)c1cc2c([nH]c1=O)CCC2.,O=C(NCC[C@@H]1CCCO1)c1cc2c([nH]c1=O)CCC2,aldehyde
148136,Add a aldehyde to the molecule CCC[C@H]1NC(=O)N(Cc2c(F)cccc2Br)C1=O.,CCC[C@H]1NC(=O)N(Cc2c(F)cccc2Br)C1=O,aldehyde
44103,Add a carboxyl to the molecule Nc1ccnc(CN(Cc2ccncc2)C2CC2)n1.,Nc1ccnc(CN(Cc2ccncc2)C2CC2)n1,carboxyl
3929,Add a amide to the molecule CCOC(=O)CNC(=O)c1cc(C)n(Cc2ccccc2)c1C.,CCOC(=O)CNC(=O)c1cc(C)n(Cc2ccccc2)c1C,amide
103088,Please add a carboxyl to the molecule COc1ccc(C(=O)N2CCc3ccc(CNC(=O)Nc4ccc(F)cc4)cc32)cc1.,COc1ccc(C(=O)N2CCc3ccc(CNC(=O)Nc4ccc(F)cc4)cc32)cc1,carboxyl
37919,Modify the molecule N#Cc1cccc(CS(=O)(=O)NCCNC(=O)c2cccnc2)c1 by adding a benzene ring.,N#Cc1cccc(CS(=O)(=O)NCCNC(=O)c2cccnc2)c1,benzene ring
146937,Add a hydroxyl to the molecule O=C(NCCNC(=O)c1ccc(F)cc1)c1ccccc1.,O=C(NCCNC(=O)c1ccc(F)cc1)c1ccccc1,hydroxyl
20552,Add a benzene ring to the molecule CC[NH2+]C[C@@]1(c2ccc(C)c(C)c2)CCC[C@H]1C.,CC[NH2+]C[C@@]1(c2ccc(C)c(C)c2)CCC[C@H]1C,benzene ring
112276,Modify the molecule CC[NH2+][C@H](Cc1ccc(CC)cc1)c1cncc(Br)c1 by adding a hydroxyl.,CC[NH2+][C@H](Cc1ccc(CC)cc1)c1cncc(Br)c1,hydroxyl
199634,Modify the molecule Cc1cc(C)c([C@H](C)[NH2+][C@H]2CCO[C@]3(CCSC3)C2)c(C)c1 by adding a hydroxyl.,Cc1cc(C)c([C@H](C)[NH2+][C@H]2CCO[C@]3(CCSC3)C2)c(C)c1,hydroxyl
217816,Add a hydroxyl to the molecule O=C(C[S@](=O)C/C=C/c1ccccc1)NNC(=O)c1ccc(F)cc1.,O=C(C[S@](=O)C/C=C/c1ccccc1)NNC(=O)c1ccc(F)cc1,hydroxyl
60607,Modify the molecule C[C@H](OC(=O)c1c2c(nc3ccccc13)/C(=C/c1ccc(Cl)cc1)CC2)C(=O)NC(N)=O by adding a benzene ring.,C[C@H](OC(=O)c1c2c(nc3ccccc13)/C(=C/c1ccc(Cl)cc1)CC2)C(=O)NC(N)=O,benzene ring
94194,Modify the molecule CC(C)c1ccc(Cn2c(CNC(=O)[C@@H]3CCCO3)nc3ccccc32)cc1 by adding a benzene ring.,CC(C)c1ccc(Cn2c(CNC(=O)[C@@H]3CCCO3)nc3ccccc32)cc1,benzene ring
158885,Modify the molecule O=S(=O)(N[C@H]1CCCC[C@H]1N1CC[NH+](C2CCCCC2)CC1)c1ccccc1 by adding a amide.,O=S(=O)(N[C@H]1CCCC[C@H]1N1CC[NH+](C2CCCCC2)CC1)c1ccccc1,amide
90526,Modify the molecule C=CCOc1ccc(Oc2nc(N(C)C)nc(N(C)C)n2)nn1 by adding a amide.,C=CCOc1ccc(Oc2nc(N(C)C)nc(N(C)C)n2)nn1,amide
117686,Please add a benzene ring to the molecule O=C1C[C@H](c2cc3c(cc2Br)OCO3)c2ccc3ccccc3c2N1.,O=C1C[C@H](c2cc3c(cc2Br)OCO3)c2ccc3ccccc3c2N1,benzene ring
248300,Modify the molecule C[C@@H](NC(=O)CC[C@H]1NC(=O)N(c2ccc(F)cc2)C1=O)c1ccc2c(c1)OCCO2 by adding a benzene ring.,C[C@@H](NC(=O)CC[C@H]1NC(=O)N(c2ccc(F)cc2)C1=O)c1ccc2c(c1)OCCO2,benzene ring
97313,Add a benzene ring to the molecule CCn1cc(CN(C)C(=O)CCn2cc(C(=O)[O-])cn2)c(C)n1.,CCn1cc(CN(C)C(=O)CCn2cc(C(=O)[O-])cn2)c(C)n1,benzene ring
210983,Please add a nitro to the molecule Cc1cc(C)n(-c2cccc(CC[NH3+])c2)n1.,Cc1cc(C)n(-c2cccc(CC[NH3+])c2)n1,nitro
21075,Please add a amide to the molecule O=Cc1ccc(N2CCN(c3ccc(C=O)cc3[N+](=O)[O-])CC2)c([N+](=O)[O-])c1.,O=Cc1ccc(N2CCN(c3ccc(C=O)cc3[N+](=O)[O-])CC2)c([N+](=O)[O-])c1,amide
172189,Please add a halo to the molecule C[C@H]1C[C@H](OCCOCCS)CC[C@H]1C.,C[C@H]1C[C@H](OCCOCCS)CC[C@H]1C,halo
79850,Modify the molecule CCCS(=O)(=O)c1nc2ncc(Cl)cc2s1 by adding a nitro.,CCCS(=O)(=O)c1nc2ncc(Cl)cc2s1,nitro
183837,Add a benzene ring to the molecule CC[C@@H](C)CNC(=O)c1cccc(C(F)(F)F)c1F.,CC[C@@H](C)CNC(=O)c1cccc(C(F)(F)F)c1F,benzene ring
45209,Modify the molecule CC[C@H](C)c1ccc(O[C@H]2O[C@H]3CO[C@H](c4ccccc4)O[C@@H]3[C@@H](O)[C@H]2NC(C)=O)cc1 by adding a amine.,CC[C@H](C)c1ccc(O[C@H]2O[C@H]3CO[C@H](c4ccccc4)O[C@@H]3[C@@H](O)[C@H]2NC(C)=O)cc1,amine
172191,Please add a aldehyde to the molecule O=C(/C=C/c1ccc2ncccc2c1)c1cccc(Br)c1.,O=C(/C=C/c1ccc2ncccc2c1)c1cccc(Br)c1,aldehyde
18662,Add a hydroxyl to the molecule CCC(CC)(NC(=O)C[C@@H]1CCC[NH2+]C1)C(=O)[O-].,CCC(CC)(NC(=O)C[C@@H]1CCC[NH2+]C1)C(=O)[O-],hydroxyl
25257,Please add a carboxyl to the molecule COc1cc(CNC(=O)Nc2ccc(F)cc2Cl)ccc1OCCO.,COc1cc(CNC(=O)Nc2ccc(F)cc2Cl)ccc1OCCO,carboxyl
108112,Modify the molecule CC(C)c1nccc(N(Cc2ccccc2)[C@H](C)CCO)n1 by adding a carboxyl.,CC(C)c1nccc(N(Cc2ccccc2)[C@H](C)CCO)n1,carboxyl
90289,Add a carboxyl to the molecule C[NH2+]C1(CCNCc2sccc2C)CCCCC1.,C[NH2+]C1(CCNCc2sccc2C)CCCCC1,carboxyl
239368,Please add a amide to the molecule CNC(=O)c1ccc(Cl)c(NC(=O)[C@@H](C[NH3+])CC(C)C)c1.,CNC(=O)c1ccc(Cl)c(NC(=O)[C@@H](C[NH3+])CC(C)C)c1,amide
203759,Add a amide to the molecule CC[C@@H](/C([O-])=N/S(=O)(=O)c1cccc(OC)c1)c1ccccc1.,CC[C@@H](/C([O-])=N/S(=O)(=O)c1cccc(OC)c1)c1ccccc1,amide
178471,Add a benzene ring to the molecule CCN(Cc1ccccn1)C(=O)C1CCC(C(=O)[O-])CC1.,CCN(Cc1ccccn1)C(=O)C1CCC(C(=O)[O-])CC1,benzene ring
59377,Add a halo to the molecule O=C(CNC(=O)C12CC3CC(CC(C3)C1)C2)N/N=C\c1cccc(O)c1.,O=C(CNC(=O)C12CC3CC(CC(C3)C1)C2)N/N=C\c1cccc(O)c1,halo
164953,Please add a benzene ring to the molecule Cc1c([C@@H]2CCCN2Cc2c(F)cccc2Br)cnn1C.,Cc1c([C@@H]2CCCN2Cc2c(F)cccc2Br)cnn1C,benzene ring
219194,Please add a benzene ring to the molecule COc1ccc(-c2nnc(SCC(=O)N[C@@H](C)C(C)C)o2)cc1.,COc1ccc(-c2nnc(SCC(=O)N[C@@H](C)C(C)C)o2)cc1,benzene ring
157229,Add a amine to the molecule CC(C)COc1ccc(COC[C@H]2O[C@H]3OC(C)(C)O[C@@H]3[C@H]3OC(C)(C)O[C@H]32)cc1.,CC(C)COc1ccc(COC[C@H]2O[C@H]3OC(C)(C)O[C@@H]3[C@H]3OC(C)(C)O[C@H]32)cc1,amine
182705,Modify the molecule O=C1NC(=O)C2(CC(C(=O)N3CCN(Cc4cccc(F)c4)CC3)C2)N1 by adding a hydroxyl.,O=C1NC(=O)C2(CC(C(=O)N3CCN(Cc4cccc(F)c4)CC3)C2)N1,hydroxyl
138446,Please add a amide to the molecule Cc1oc(C(=O)N(C)c2cccc(C(C)C)c2)cc1S(=O)(=O)N(C)C.,Cc1oc(C(=O)N(C)c2cccc(C(C)C)c2)cc1S(=O)(=O)N(C)C,amide
64707,Add a benzene ring to the molecule Cc1nc(-c2ccc(S(=O)(=O)N[C@H](C)C[NH+]3C[C@@H](C)C[C@@H](C)C3)cc2)co1.,Cc1nc(-c2ccc(S(=O)(=O)N[C@H](C)C[NH+]3C[C@@H](C)C[C@@H](C)C3)cc2)co1,benzene ring
2472,Add a hydroxyl to the molecule Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1.,Cn1nc(C(=O)NCc2ccco2)cc1NC(=O)Cc1ccccc1,hydroxyl
40288,Please add a hydroxyl to the molecule NC(=O)NC(=O)OCCCN1CCc2ccc(Br)cc21.,NC(=O)NC(=O)OCCCN1CCc2ccc(Br)cc21,hydroxyl
237800,Add a benzene ring to the molecule CCOC(=O)c1ccccc1[N-]S(=O)(=O)c1cccc(F)c1.,CCOC(=O)c1ccccc1[N-]S(=O)(=O)c1cccc(F)c1,benzene ring
101106,Modify the molecule CC1(C)C(=O)NCCN1C(=O)CSc1nccc(-c2ccc(Cl)cc2)n1 by adding a hydroxyl.,CC1(C)C(=O)NCCN1C(=O)CSc1nccc(-c2ccc(Cl)cc2)n1,hydroxyl
120090,Add a aldehyde to the molecule O=C1NC2(CCCCCC2)C(=O)N1Cc1c(Cl)cccc1Cl.,O=C1NC2(CCCCCC2)C(=O)N1Cc1c(Cl)cccc1Cl,aldehyde
33264,Modify the molecule CSc1ccc(CN(C)C(=O)C(=O)Nc2ccccc2F)cc1 by adding a benzene ring.,CSc1ccc(CN(C)C(=O)C(=O)Nc2ccccc2F)cc1,benzene ring
141652,Add a aldehyde to the molecule CNc1ccc([N+](=O)[O-])cc1C(=O)NCCNC(=O)c1ccc(O)cc1.,CNc1ccc([N+](=O)[O-])cc1C(=O)NCCNC(=O)c1ccc(O)cc1,aldehyde
164712,Please add a carboxyl to the molecule Cc1ccc(NC(=O)[C@@H]2N=NC3=C2CCc2ccccc23)cc1C.,Cc1ccc(NC(=O)[C@@H]2N=NC3=C2CCc2ccccc23)cc1C,carboxyl
88806,Modify the molecule C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1 by adding a benzene ring.,C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1,benzene ring
171459,Add a carboxyl to the molecule CCc1nc2n(n1)CCC[C@@H]2NC(=O)N[C@H](c1ncccc1C)C(C)C.,CCc1nc2n(n1)CCC[C@@H]2NC(=O)N[C@H](c1ncccc1C)C(C)C,carboxyl
183579,Please add a benzene ring to the molecule Cc1nnc2n1CCC[C@H]2NC(=O)c1ncoc1-c1cccs1.,Cc1nnc2n1CCC[C@H]2NC(=O)c1ncoc1-c1cccs1,benzene ring
208382,Modify the molecule C=CCNC(=O)c1ccc(NC(=O)C(=O)N2CCC[C@H](C)CC2)cc1 by adding a halo.,C=CCNC(=O)c1ccc(NC(=O)C(=O)N2CCC[C@H](C)CC2)cc1,halo
38784,Modify the molecule CCc1nc(C(=O)NC2C[C@@H]3CCC[C@H](C2)[NH+]3C)n[nH]1 by adding a hydroxyl.,CCc1nc(C(=O)NC2C[C@@H]3CCC[C@H](C2)[NH+]3C)n[nH]1,hydroxyl
190350,Please add a amide to the molecule O=C(Nc1ccccc1C(=O)NCCC1=c2cc(Cl)ccc2=[NH+]C1)C1=CSCCO1.,O=C(Nc1ccccc1C(=O)NCCC1=c2cc(Cl)ccc2=[NH+]C1)C1=CSCCO1,amide
51151,Modify the molecule COc1ccc(N(C)C(=O)c2cc3ccc(C)cc3[nH]2)cc1OC by adding a hydroxyl.,COc1ccc(N(C)C(=O)c2cc3ccc(C)cc3[nH]2)cc1OC,hydroxyl
42310,Modify the molecule CCCC(CCC)C(=O)Nc1ccc2c(c1)C(=O)NCC2 by adding a hydroxyl.,CCCC(CCC)C(=O)Nc1ccc2c(c1)C(=O)NCC2,hydroxyl
236048,Add a hydroxyl to the molecule CC(C)COc1ccc(NC(=O)C(=O)N[C@@H]2CC=CCC2)cc1Cl.,CC(C)COc1ccc(NC(=O)C(=O)N[C@@H]2CC=CCC2)cc1Cl,hydroxyl
155886,Please add a hydroxyl to the molecule CC(C)NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc([N+](=O)[O-])cc1.,CC(C)NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc([N+](=O)[O-])cc1,hydroxyl
78035,Modify the molecule O=C(Nc1ccn(Cc2cccc3cccnc23)n1)[C@@H]1CCCO1 by adding a amide.,O=C(Nc1ccn(Cc2cccc3cccnc23)n1)[C@@H]1CCCO1,amide
13861,Please add a nitro to the molecule CC[C@@H](C)NC(=O)[C@H](C)NC(=O)Nc1cnn(CC(F)F)c1.,CC[C@@H](C)NC(=O)[C@H](C)NC(=O)Nc1cnn(CC(F)F)c1,nitro
88193,Modify the molecule C[NH2+]Cc1cncc(N2CCC[C@H]3CCC[C@@H]32)n1 by adding a halo.,C[NH2+]Cc1cncc(N2CCC[C@H]3CCC[C@@H]32)n1,halo
179612,Modify the molecule COc1ccc([C@@H]2c3c(C)nn(-c4cccc(Cl)c4)c3Oc3ncn4nc(C)nc4c32)cc1 by adding a hydroxyl.,COc1ccc([C@@H]2c3c(C)nn(-c4cccc(Cl)c4)c3Oc3ncn4nc(C)nc4c32)cc1,hydroxyl
148329,Add a halo to the molecule COc1ccccc1C(=O)NNC(=O)[C@@H]1CC=CCC1.,COc1ccccc1C(=O)NNC(=O)[C@@H]1CC=CCC1,halo
186319,Add a benzene ring to the molecule Cc1[nH]ncc1CCCNc1ncnc2cc(F)c(F)cc12.,Cc1[nH]ncc1CCCNc1ncnc2cc(F)c(F)cc12,benzene ring
8795,Add a hydroxyl to the molecule C=CCNC(=O)[C@H](C)SCc1ccc(-n2cccn2)cc1.,C=CCNC(=O)[C@H](C)SCc1ccc(-n2cccn2)cc1,hydroxyl
133324,Add a amide to the molecule COCc1ccc(C(=O)NC(c2cccs2)c2cccs2)cc1.,COCc1ccc(C(=O)NC(c2cccs2)c2cccs2)cc1,amide
39120,Modify the molecule Cc1ccc(OCC(=O)N(C)Cc2nc(-c3ccccc3)no2)c(Br)c1 by adding a amide.,Cc1ccc(OCC(=O)N(C)Cc2nc(-c3ccccc3)no2)c(Br)c1,amide
6353,Please add a hydroxyl to the molecule CCCS(=O)(=O)[N-]c1ccc2c[nH]nc2c1.,CCCS(=O)(=O)[N-]c1ccc2c[nH]nc2c1,hydroxyl
314,Modify the molecule O=C(c1c(-c2ccccc2)nc2sc3c(n12)CCCC3)C(F)(F)F by adding a hydroxyl.,O=C(c1c(-c2ccccc2)nc2sc3c(n12)CCCC3)C(F)(F)F,hydroxyl
152047,Modify the molecule Cc1nc(C)c([C@H](C)NC(=O)c2sc3nc(C(F)(F)F)ccc3c2C)s1 by adding a halo.,Cc1nc(C)c([C@H](C)NC(=O)c2sc3nc(C(F)(F)F)ccc3c2C)s1,halo
134905,Please add a aldehyde to the molecule O=C(/C=C/c1ccc(N2CCCC2=O)cc1)Nc1cc(Cl)ccc1OC[C@H]1CCCO1.,O=C(/C=C/c1ccc(N2CCCC2=O)cc1)Nc1cc(Cl)ccc1OC[C@H]1CCCO1,aldehyde
35648,Please add a benzene ring to the molecule CC(C)([C@@H]([NH3+])CC1CC1)[NH+]1CCCCC1.,CC(C)([C@@H]([NH3+])CC1CC1)[NH+]1CCCCC1,benzene ring
215873,Add a carboxyl to the molecule CC(=O)C1=C(C)C(C(=O)CSc2nnc(-c3ccncc3)n2-c2cccc(Cl)c2C)=N[C@H]1C.,CC(=O)C1=C(C)C(C(=O)CSc2nnc(-c3ccncc3)n2-c2cccc(Cl)c2C)=N[C@H]1C,carboxyl
80261,Please add a amine to the molecule Cc1ccc(S(=O)(=O)CCCn2c3c(sc2=O)C[C@H](C)CC3)cc1.,Cc1ccc(S(=O)(=O)CCCn2c3c(sc2=O)C[C@H](C)CC3)cc1,amine
170515,Add a hydroxyl to the molecule Cc1cc(C)c2oc3c(c(=O)c2c1)[C@@H](c1ccc(Br)cc1)N(CCCO)C3=O.,Cc1cc(C)c2oc3c(c(=O)c2c1)[C@@H](c1ccc(Br)cc1)N(CCCO)C3=O,hydroxyl
234430,Please add a halo to the molecule O=c1n(Cc2cccc(F)c2)nc2nc(N3CCCC3)ccn12.,O=c1n(Cc2cccc(F)c2)nc2nc(N3CCCC3)ccn12,halo
73623,Please add a hydroxyl to the molecule CC(C)[C@](C)(C#N)NC(=O)CNc1cc2c(cc1Cl)OCCCO2.,CC(C)[C@](C)(C#N)NC(=O)CNc1cc2c(cc1Cl)OCCCO2,hydroxyl
85274,Add a amide to the molecule CC[NH+](CCC#N)CC[C@H]1CCCC1=O.,CC[NH+](CCC#N)CC[C@H]1CCCC1=O,amide
36321,Modify the molecule COc1cccc(C(=O)N2[C@H](C)CCC[C@H]2C)c1 by adding a halo.,COc1cccc(C(=O)N2[C@H](C)CCC[C@H]2C)c1,halo
213238,Add a benzene ring to the molecule CC[C@@H](NC(=O)C(=O)Nc1ccc(OC)cc1)c1c(C)nn(C)c1C.,CC[C@@H](NC(=O)C(=O)Nc1ccc(OC)cc1)c1c(C)nn(C)c1C,benzene ring
223402,Please add a halo to the molecule Cc1ccc(S(=O)(=O)N2CCN(Cc3nonc3C)CC2)cc1.,Cc1ccc(S(=O)(=O)N2CCN(Cc3nonc3C)CC2)cc1,halo
203724,Please add a benzene ring to the molecule CCCn1c2ccccc2c2nnc(S[C@H](C)C(=O)N[C@@H](C)CC)nc21.,CCCn1c2ccccc2c2nnc(S[C@H](C)C(=O)N[C@@H](C)CC)nc21,benzene ring
66770,Modify the molecule Cc1ccc(CN2CCN(/N=C\c3ccccc3F)CC2)c(C)c1 by adding a amide.,Cc1ccc(CN2CCN(/N=C\c3ccccc3F)CC2)c(C)c1,amide
112925,Modify the molecule C[C@@H]1OCC[C@@H]1C(=O)N1CCN(Cc2ccc(F)cc2Cl)CC1 by adding a nitro.,C[C@@H]1OCC[C@@H]1C(=O)N1CCN(Cc2ccc(F)cc2Cl)CC1,nitro
48514,Modify the molecule Cc1nn(Cc2csc(C=O)c2)c(C)c1[N+](=O)[O-] by adding a halo.,Cc1nn(Cc2csc(C=O)c2)c(C)c1[N+](=O)[O-],halo
158394,Add a hydroxyl to the molecule Cc1ccc(Cl)cc1NC(=O)[C@H](C)S(=O)(=O)c1cccc[n+]1[O-].,Cc1ccc(Cl)cc1NC(=O)[C@H](C)S(=O)(=O)c1cccc[n+]1[O-],hydroxyl
95943,Modify the molecule CC1(C)C[NH2+]CCN1C(=O)N1CCOCC1 by adding a halo.,CC1(C)C[NH2+]CCN1C(=O)N1CCOCC1,halo
102368,Please add a benzene ring to the molecule C[C@H](Nc1cccc(N2CCCC2=O)c1)C(=O)Nc1ccc(Oc2ccccc2)cc1.,C[C@H](Nc1cccc(N2CCCC2=O)c1)C(=O)Nc1ccc(Oc2ccccc2)cc1,benzene ring
207011,Please add a benzene ring to the molecule Cc1ccc([C@@H]2CSCCN2C(=O)CNC(=O)c2ccoc2C)o1.,Cc1ccc([C@@H]2CSCCN2C(=O)CNC(=O)c2ccoc2C)o1,benzene ring
74325,Add a benzene ring to the molecule Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1.,Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1,benzene ring
146422,Add a amide to the molecule COc1ccc(NC(=O)C2(c3cccs3)CCCC2)cc1OC.,COc1ccc(NC(=O)C2(c3cccs3)CCCC2)cc1OC,amide
157564,Please add a carboxyl to the molecule CC[NH2+][C@@]1(CO)CC[C@@H](Oc2ccccc2F)C1.,CC[NH2+][C@@]1(CO)CC[C@@H](Oc2ccccc2F)C1,carboxyl
152572,Please add a carboxyl to the molecule Cc1ccc(/[NH+]=c2\oc3cc(O)ccc3cc2C(=O)Nc2nccs2)cc1.,Cc1ccc(/[NH+]=c2\oc3cc(O)ccc3cc2C(=O)Nc2nccs2)cc1,carboxyl
228875,Modify the molecule C[C@H]1CC(C(=O)N2CCC(Cc3ccccc3)CC2)C[C@H](C)O1 by adding a amide.,C[C@H]1CC(C(=O)N2CCC(Cc3ccccc3)CC2)C[C@H](C)O1,amide
163091,Modify the molecule CSc1ccc2nc(NC(=O)c3ccc(N4C(=O)CCC4=O)cc3)sc2c1 by adding a benzene ring.,CSc1ccc2nc(NC(=O)c3ccc(N4C(=O)CCC4=O)cc3)sc2c1,benzene ring
221993,Add a benzene ring to the molecule O=C(c1cn[nH]c1-c1cccc(Br)c1)N1CCC([NH+]2CCCCC2)CC1.,O=C(c1cn[nH]c1-c1cccc(Br)c1)N1CCC([NH+]2CCCCC2)CC1,benzene ring
132860,Add a aldehyde to the molecule CCC(CC)(C(=O)c1cscc1Br)[NH+](C)C.,CCC(CC)(C(=O)c1cscc1Br)[NH+](C)C,aldehyde
39778,Modify the molecule CC(=O)c1ccccc1C(=O)NCc1ccnc(OCC(F)F)c1 by adding a hydroxyl.,CC(=O)c1ccccc1C(=O)NCc1ccnc(OCC(F)F)c1,hydroxyl
196251,Please add a aldehyde to the molecule Cc1cc(N(C)C)ccc1NC(=O)C[C@H]1SC(N)=NC1=O.,Cc1cc(N(C)C)ccc1NC(=O)C[C@H]1SC(N)=NC1=O,aldehyde
217937,Please add a benzene ring to the molecule CC(C)(C)c1csc(C[C@@]2(C(=O)[O-])C[C@H]3CC[C@@H]2C3)n1.,CC(C)(C)c1csc(C[C@@]2(C(=O)[O-])C[C@H]3CC[C@@H]2C3)n1,benzene ring
28919,Please add a benzene ring to the molecule O=C(C[C@H]1CCCCC[NH2+]1)c1ccc2ccccc2c1.,O=C(C[C@H]1CCCCC[NH2+]1)c1ccc2ccccc2c1,benzene ring
115084,Modify the molecule Cc1ccc(NC(=O)[C@H]2[C@@H](c3ccccn3)n3ncnc3N[C@@H]2C)c(C)c1 by adding a halo.,Cc1ccc(NC(=O)[C@H]2[C@@H](c3ccccn3)n3ncnc3N[C@@H]2C)c(C)c1,halo
159739,Add a benzene ring to the molecule Cc1ccc2nc(N(CC[NH+](C)C)C(=O)c3cc(C)no3)sc2c1.,Cc1ccc2nc(N(CC[NH+](C)C)C(=O)c3cc(C)no3)sc2c1,benzene ring
152198,Please add a thiol to the molecule CC1=C(NC(=O)CSc2nc(-c3cccs3)c(-c3cccs3)[nH]2)[C@H](C)N(C)N1.,CC1=C(NC(=O)CSc2nc(-c3cccs3)c(-c3cccs3)[nH]2)[C@H](C)N(C)N1,thiol
202014,Modify the molecule COc1ccccc1CC1CC[NH+](Cc2ccc([S@](C)=O)cc2)CC1 by adding a benzene ring.,COc1ccccc1CC1CC[NH+](Cc2ccc([S@](C)=O)cc2)CC1,benzene ring
23718,Modify the molecule CC(C)NC(=O)[C@]12CC[C@](C)(/C(=N/O)C1=O)C2(C)C by adding a nitro.,CC(C)NC(=O)[C@]12CC[C@](C)(/C(=N/O)C1=O)C2(C)C,nitro
245123,Modify the molecule CCCC[C@@H](COC)NC(=O)Nc1ccc2c(c1)oc(=O)n2C by adding a amide.,CCCC[C@@H](COC)NC(=O)Nc1ccc2c(c1)oc(=O)n2C,amide
29299,Modify the molecule Fc1cc(Cl)cnc1N1CCC2(CC1)OCCO2 by adding a nitro.,Fc1cc(Cl)cnc1N1CCC2(CC1)OCCO2,nitro
90236,Please add a hydroxyl to the molecule Cc1ccc(C(C)C)cc1O[C@H](C)C(=O)[C@@H](C#N)c1ccc(F)cn1.,Cc1ccc(C(C)C)cc1O[C@H](C)C(=O)[C@@H](C#N)c1ccc(F)cn1,hydroxyl
242333,Modify the molecule COc1ccc([N+](=O)[O-])cc1N1C(=O)[C@@H]2[C@H]3c4ccccc4C=CN3[C@H](C(C)=O)[C@@H]2C1=O by adding a amide.,COc1ccc([N+](=O)[O-])cc1N1C(=O)[C@@H]2[C@H]3c4ccccc4C=CN3[C@H](C(C)=O)[C@@H]2C1=O,amide
225510,Modify the molecule CCC[NH2+]C/C(=C\c1cccc(C)c1C)C(C)C by adding a amide.,CCC[NH2+]C/C(=C\c1cccc(C)c1C)C(C)C,amide
83597,Add a amide to the molecule COCCS(=O)(=O)NC[C@@H](O)c1c(Cl)cccc1Cl.,COCCS(=O)(=O)NC[C@@H](O)c1c(Cl)cccc1Cl,amide
245472,Add a carboxyl to the molecule COC[C@H](O)C[NH+]1CCC(NC(=O)c2cccc(Cl)c2[N+](=O)[O-])CC1.,COC[C@H](O)C[NH+]1CCC(NC(=O)c2cccc(Cl)c2[N+](=O)[O-])CC1,carboxyl
89943,Add a carboxyl to the molecule O=C(NCCc1cccs1)C1CCN(C(=O)c2cc3ccccc3cc2NC(=O)C2CC2)CC1.,O=C(NCCc1cccs1)C1CCN(C(=O)c2cc3ccccc3cc2NC(=O)C2CC2)CC1,carboxyl
16423,Add a amine to the molecule COc1cc(CN2CC[NH+]([C@H]3CCC[C@H](C)C3)CC2)cc(OC)c1O.,COc1cc(CN2CC[NH+]([C@H]3CCC[C@H](C)C3)CC2)cc(OC)c1O,amine
167196,Modify the molecule C[C@@H]1Oc2ccc(NC(=O)N3CCCC3(C)C)cc2NC1=O by adding a benzene ring.,C[C@@H]1Oc2ccc(NC(=O)N3CCCC3(C)C)cc2NC1=O,benzene ring
145815,Please add a nitro to the molecule CC[C@H]1C(=O)NCCN1C(=O)CCCCOc1cc(C)ccc1C.,CC[C@H]1C(=O)NCCN1C(=O)CCCCOc1cc(C)ccc1C,nitro
805,Please add a nitro to the molecule Cc1ccc(C(=O)Cc2cccc(O)c2)cc1.,Cc1ccc(C(=O)Cc2cccc(O)c2)cc1,nitro
3273,Modify the molecule C[C@H]1CCCCN1C(=O)CSc1ccc(N)cc1 by adding a aldehyde.,C[C@H]1CCCCN1C(=O)CSc1ccc(N)cc1,aldehyde
95611,Please add a nitrile to the molecule C=COCCC[NH2+]Cc1ccc(Br)c(C)c1.,C=COCCC[NH2+]Cc1ccc(Br)c(C)c1,nitrile
236772,Add a carboxyl to the molecule CC[NH+](CC(=O)NCCC#N)Cc1ccc(Br)s1.,CC[NH+](CC(=O)NCCC#N)Cc1ccc(Br)s1,carboxyl
177053,Please add a amine to the molecule C/[NH+]=C(/NC[C@@H](C)c1cccs1)N[C@H]1[C@@H]2CCO[C@@H]2C1(C)C.,C/[NH+]=C(/NC[C@@H](C)c1cccs1)N[C@H]1[C@@H]2CCO[C@@H]2C1(C)C,amine
206769,Modify the molecule Cc1cc(C)nc(NNC(=O)c2cc(-c3ccncc3)nc3ccccc23)n1 by adding a benzene ring.,Cc1cc(C)nc(NNC(=O)c2cc(-c3ccncc3)nc3ccccc23)n1,benzene ring
228942,Modify the molecule O=C(c1ccc(-n2ccnc2)nc1)N1CCCC[C@H]1CCc1ccccc1 by adding a hydroxyl.,O=C(c1ccc(-n2ccnc2)nc1)N1CCCC[C@H]1CCc1ccccc1,hydroxyl
72177,Modify the molecule C=C(C)CSc1nnc(-c2ccoc2C)n1C by adding a amine.,C=C(C)CSc1nnc(-c2ccoc2C)n1C,amine
82612,Modify the molecule CCSCC[C@@H](C)N(C)C(=O)c1ccc(N)c([N+](=O)[O-])c1 by adding a aldehyde.,CCSCC[C@@H](C)N(C)C(=O)c1ccc(N)c([N+](=O)[O-])c1,aldehyde
182966,Please add a hydroxyl to the molecule C[C@H]1C[C@H]([NH+](C)Cc2ccc(N3CCCCCC3)cc2)CCN1C.,C[C@H]1C[C@H]([NH+](C)Cc2ccc(N3CCCCCC3)cc2)CCN1C,hydroxyl
31229,Please add a amide to the molecule COCc1cc(NC(=O)N(C[C@H]2CCOC2)C2CC2)ncn1.,COCc1cc(NC(=O)N(C[C@H]2CCOC2)C2CC2)ncn1,amide
82992,Add a aldehyde to the molecule COc1ccc(NC(=O)[C@H]2CCO[C@H]2C)c(C)c1.,COc1ccc(NC(=O)[C@H]2CCO[C@H]2C)c(C)c1,aldehyde
247087,Add a aldehyde to the molecule CCOCc1ccc(NC(=O)COc2ccc(F)cc2)cc1.,CCOCc1ccc(NC(=O)COc2ccc(F)cc2)cc1,aldehyde
105731,Please add a aldehyde to the molecule CCSC1=C(C#N)[C@@H](CC(C)C)C2=C([O-])CCCC2=N1.,CCSC1=C(C#N)[C@@H](CC(C)C)C2=C([O-])CCCC2=N1,aldehyde
59610,Add a amine to the molecule Cc1cc(C(=O)NCc2ccc(N3CCOCC3)cc2)c(C)n1C1CC1.,Cc1cc(C(=O)NCc2ccc(N3CCOCC3)cc2)c(C)n1C1CC1,amine
6417,Modify the molecule CCOc1ccc([C@H](CC[C@@H]2CCCCO2)[NH2+]C)c(Br)c1 by adding a carboxyl.,CCOc1ccc([C@H](CC[C@@H]2CCCCO2)[NH2+]C)c(Br)c1,carboxyl
188074,Modify the molecule CSc1ccc(NC(=O)c2cc(C3CC3)nc3c2cnn3C(C)C)cc1 by adding a hydroxyl.,CSc1ccc(NC(=O)c2cc(C3CC3)nc3c2cnn3C(C)C)cc1,hydroxyl
27788,Modify the molecule COCC(=O)N1CCc2sccc2[C@H]1C(=O)OC by adding a benzene ring.,COCC(=O)N1CCc2sccc2[C@H]1C(=O)OC,benzene ring
50705,Add a carboxyl to the molecule CC(=O)c1ccc(NC(=O)Cc2c(C)nc3nc(-c4ccccc4Cl)nn3c2C)cc1.,CC(=O)c1ccc(NC(=O)Cc2c(C)nc3nc(-c4ccccc4Cl)nn3c2C)cc1,carboxyl
91092,Modify the molecule CC(=O)c1ccc(NC(=O)CN(C)S(=O)(=O)c2ccccc2)cc1C by adding a halo.,CC(=O)c1ccc(NC(=O)CN(C)S(=O)(=O)c2ccccc2)cc1C,halo
29056,Modify the molecule O=C(c1nccn2ccnc12)N1CCC[C@@H]1c1nc2ccccc2s1 by adding a benzene ring.,O=C(c1nccn2ccnc12)N1CCC[C@@H]1c1nc2ccccc2s1,benzene ring
110868,Add a amide to the molecule Cc1cc(C)c2cc(C(=O)NC[C@@H](C)C[C@@H](C)O)[nH]c2c1.,Cc1cc(C)c2cc(C(=O)NC[C@@H](C)C[C@@H](C)O)[nH]c2c1,amide
229914,Add a amine to the molecule CNC(=O)C[NH2+]C[C@H]1CCCN(S(C)(=O)=O)C1.,CNC(=O)C[NH2+]C[C@H]1CCCN(S(C)(=O)=O)C1,amine
126967,Please add a amide to the molecule O=[N+]([O-])c1ccc(S(=O)(=O)NCC[C@@H](O)C2CC2)cc1.,O=[N+]([O-])c1ccc(S(=O)(=O)NCC[C@@H](O)C2CC2)cc1,amide
133327,Modify the molecule CS(=O)(=O)[C@H]1CC[C@H](OC(=O)c2sccc2SC(F)F)C1 by adding a benzene ring.,CS(=O)(=O)[C@H]1CC[C@H](OC(=O)c2sccc2SC(F)F)C1,benzene ring
142171,Please add a amide to the molecule Cc1cc(C)n2nc(C(=O)NCc3nccc4ccccc34)nc2n1.,Cc1cc(C)n2nc(C(=O)NCc3nccc4ccccc34)nc2n1,amide
28434,Modify the molecule CCC1(CC)CCN(c2nc(C)c(C(C)=O)s2)C1 by adding a carboxyl.,CCC1(CC)CCN(c2nc(C)c(C(C)=O)s2)C1,carboxyl
31817,Add a amide to the molecule COc1ccc(OCC(=O)N2CCN(c3cccc[nH+]3)CC2)cc1.,COc1ccc(OCC(=O)N2CCN(c3cccc[nH+]3)CC2)cc1,amide
8329,Please add a amide to the molecule Cn1c(=O)c2c(ncn2CCOc2cccc(C#N)c2)n(C)c1=O.,Cn1c(=O)c2c(ncn2CCOc2cccc(C#N)c2)n(C)c1=O,amide
181663,Modify the molecule O=C(Nc1ccc2c(c1)C(=O)c1ccccc1C2=O)c1ccc(F)cc1F by adding a hydroxyl.,O=C(Nc1ccc2c(c1)C(=O)c1ccccc1C2=O)c1ccc(F)cc1F,hydroxyl
151871,Please add a benzene ring to the molecule CCC(=O)N(C1CC1)[C@H]1NN=C(S[C@@H]2C(=O)[NH+]=c3ccccc3=C2C)S1.,CCC(=O)N(C1CC1)[C@H]1NN=C(S[C@@H]2C(=O)[NH+]=c3ccccc3=C2C)S1,benzene ring
95154,Add a halo to the molecule CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O.,CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O,halo
2848,Please add a nitro to the molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1.,CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1,nitro
237899,Please add a benzene ring to the molecule O=C(CSc1nc2cc(Cl)ccc2o1)Nc1cc(F)ccc1F.,O=C(CSc1nc2cc(Cl)ccc2o1)Nc1cc(F)ccc1F,benzene ring
202021,Add a benzene ring to the molecule CSc1ccc(Cl)cc1NC(=O)NCCc1cccc(F)c1.,CSc1ccc(Cl)cc1NC(=O)NCCc1cccc(F)c1,benzene ring
130062,Modify the molecule Cc1cccc(C(=O)NC(=S)N2CCN(C)CC2)c1 by adding a benzene ring.,Cc1cccc(C(=O)NC(=S)N2CCN(C)CC2)c1,benzene ring
242178,Modify the molecule O=C(OCCO)N1CCN(C[C@@H]2CCCO2)CC1 by adding a hydroxyl.,O=C(OCCO)N1CCN(C[C@@H]2CCCO2)CC1,hydroxyl
20263,Please add a hydroxyl to the molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NN1C(=O)c2ccccc2C1=O.,C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NN1C(=O)c2ccccc2C1=O,hydroxyl
56708,Please add a benzene ring to the molecule Cc1ccc(N(CCC#N)C(=O)COc2ccc(F)cc2F)cc1C.,Cc1ccc(N(CCC#N)C(=O)COc2ccc(F)cc2F)cc1C,benzene ring
72494,Please add a halo to the molecule Cc1cc(CC(=O)NCC2([NH2+][C@@H](C)c3ccccc3)CCCC2)no1.,Cc1cc(CC(=O)NCC2([NH2+][C@@H](C)c3ccccc3)CCCC2)no1,halo
149872,Modify the molecule Cc1ccsc1[C@H](C)[C@H](C)[NH2+]C(C)C by adding a amide.,Cc1ccsc1[C@H](C)[C@H](C)[NH2+]C(C)C,amide
29178,Modify the molecule COc1cccc(N2C[C@H](C)Cn3c2nc2c3c(=O)n(CCc3ccccc3)c(=O)n2C)c1 by adding a benzene ring.,COc1cccc(N2C[C@H](C)Cn3c2nc2c3c(=O)n(CCc3ccccc3)c(=O)n2C)c1,benzene ring
122305,Add a nitro to the molecule N#C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1cccc(Cl)c1.,N#C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1cccc(Cl)c1,nitro
60231,Add a amine to the molecule CC(=O)N1C=Cc2ccccc2[C@@H]1CC(=O)NCCCCC(C)C.,CC(=O)N1C=Cc2ccccc2[C@@H]1CC(=O)NCCCCC(C)C,amine
78989,Please add a nitro to the molecule CNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1ccc(OC)cc1.,CNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1ccc(OC)cc1,nitro
169655,Add a benzene ring to the molecule C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1.,C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1,benzene ring
201919,Modify the molecule CC[n+]1c(/C=C2\Sc3ccccc3N2C)ccc2cc(C)ccc21 by adding a aldehyde.,CC[n+]1c(/C=C2\Sc3ccccc3N2C)ccc2cc(C)ccc21,aldehyde
19787,Add a hydroxyl to the molecule Cc1nn(C)cc1[C@H]1C[C@H](C(=O)Nc2ccccc2C(F)(F)F)N(C)S(=O)(=O)N1.,Cc1nn(C)cc1[C@H]1C[C@H](C(=O)Nc2ccccc2C(F)(F)F)N(C)S(=O)(=O)N1,hydroxyl
246307,Please add a amide to the molecule CC(C)N(C(=O)COC(=O)c1nc(Cl)c(Cl)c(N)c1Cl)C(C)C.,CC(C)N(C(=O)COC(=O)c1nc(Cl)c(Cl)c(N)c1Cl)C(C)C,amide
80279,Modify the molecule CC(C)[NH+](C)Cc1ccccc1C/[NH+]=C(/N)N[C@@H]1CCOc2ccccc21 by adding a nitro.,CC(C)[NH+](C)Cc1ccccc1C/[NH+]=C(/N)N[C@@H]1CCOc2ccccc21,nitro
218273,Add a amide to the molecule CCOC(=O)[C@@H](C)N1C(=O)S/C(=C/C=C/c2ccc(OC)cc2)C1=O.,CCOC(=O)[C@@H](C)N1C(=O)S/C(=C/C=C/c2ccc(OC)cc2)C1=O,amide
196233,Please add a amine to the molecule CC(=O)NCCNc1cc(C)[nH+]c(N2CCCCC2)n1.,CC(=O)NCCNc1cc(C)[nH+]c(N2CCCCC2)n1,amine
211475,Please add a benzene ring to the molecule Cc1nccn1-c1cncc(N2CC[C@@H](S(=O)(=O)NC(C)C)C2)n1.,Cc1nccn1-c1cncc(N2CC[C@@H](S(=O)(=O)NC(C)C)C2)n1,benzene ring
54626,Modify the molecule CCCN1C(=O)[C@@]2(C(C(=O)OC)=C(N)OC3=C2C(=O)CCC3)c2ccccc21 by adding a benzene ring.,CCCN1C(=O)[C@@]2(C(C(=O)OC)=C(N)OC3=C2C(=O)CCC3)c2ccccc21,benzene ring
230275,Please add a benzene ring to the molecule O=C(NC[C@H](O)c1ccoc1)c1cccc(C(F)(F)F)c1.,O=C(NC[C@H](O)c1ccoc1)c1cccc(C(F)(F)F)c1,benzene ring
113626,Add a amide to the molecule Cc1c(C(=O)NC(C(N)=O)C(N)=O)cnn1-c1ccccc1.,Cc1c(C(=O)NC(C(N)=O)C(N)=O)cnn1-c1ccccc1,amide
121985,Please add a hydroxyl to the molecule O=C1NC2(CC[NH2+]CC2)C(=O)N1CCc1cccc(C(F)(F)F)c1.,O=C1NC2(CC[NH2+]CC2)C(=O)N1CCc1cccc(C(F)(F)F)c1,hydroxyl
99273,Modify the molecule CCOC1(OCC)[C@]2(Cl)C(Cl)=C(Cl)[C@@]1(Cl)[C@H]1C(=O)C=CC(=O)[C@H]12 by adding a benzene ring.,CCOC1(OCC)[C@]2(Cl)C(Cl)=C(Cl)[C@@]1(Cl)[C@H]1C(=O)C=CC(=O)[C@H]12,benzene ring
20368,Please add a thiol to the molecule C[C@@H](NC[C@H](O)c1ccncc1)c1cc(F)c(F)c(F)c1.,C[C@@H](NC[C@H](O)c1ccncc1)c1cc(F)c(F)c(F)c1,thiol
133556,Add a amide to the molecule C[C@H](c1ccc(Cl)cc1Cl)[NH+]1CCC(OCCC[NH3+])CC1.,C[C@H](c1ccc(Cl)cc1Cl)[NH+]1CCC(OCCC[NH3+])CC1,amide
135106,Add a amide to the molecule O=Cc1c(Cl)cccc1Sc1ccncc1.,O=Cc1c(Cl)cccc1Sc1ccncc1,amide
93648,Add a carboxyl to the molecule CC(=O)Nc1ccc(-n2nnnc2SCC(=O)N(C2CCCCC2)C2CCCCC2)cc1.,CC(=O)Nc1ccc(-n2nnnc2SCC(=O)N(C2CCCCC2)C2CCCCC2)cc1,carboxyl
108418,Modify the molecule Cc1cccc(NC(=O)[C@H]2CCc3[nH]c[nH+]c3C2)c1 by adding a benzene ring.,Cc1cccc(NC(=O)[C@H]2CCc3[nH]c[nH+]c3C2)c1,benzene ring
109962,Modify the molecule C[C@H](NC(=O)Cc1csc(-c2cccs2)n1)c1ccc2c(c1)NC(=O)CO2 by adding a amine.,C[C@H](NC(=O)Cc1csc(-c2cccs2)n1)c1ccc2c(c1)NC(=O)CO2,amine
183123,Please add a halo to the molecule COc1ccc([C@H]([NH3+])c2n[nH]c(C)n2)cc1OC.,COc1ccc([C@H]([NH3+])c2n[nH]c(C)n2)cc1OC,halo
142575,Modify the molecule Cc1cc(C)c(/C([O-])=N/S(=O)(=O)C[C@H]2CCCCO2)o1 by adding a amine.,Cc1cc(C)c(/C([O-])=N/S(=O)(=O)C[C@H]2CCCCO2)o1,amine
43815,Modify the molecule CC[NH2+]C(C)(C)C(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F by adding a hydroxyl.,CC[NH2+]C(C)(C)C(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F,hydroxyl
184520,Modify the molecule COC(=O)[C@@H]1CCN(C(=O)c2ncoc2-c2ccco2)c2ccccc21 by adding a amine.,COC(=O)[C@@H]1CCN(C(=O)c2ncoc2-c2ccco2)c2ccccc21,amine
136961,Please add a nitro to the molecule O=C(CCc1ccsc1)OCC(=O)c1ccc[nH]1.,O=C(CCc1ccsc1)OCC(=O)c1ccc[nH]1,nitro
126707,Please add a hydroxyl to the molecule CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)NCc1nnc3n1CCC3)C2.,CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)NCc1nnc3n1CCC3)C2,hydroxyl
78487,Modify the molecule Cc1nc(C(=O)N2CCC(c3nnc(C(C)C)o3)CC2)cs1 by adding a benzene ring.,Cc1nc(C(=O)N2CCC(c3nnc(C(C)C)o3)CC2)cs1,benzene ring
40327,Modify the molecule CC(C)(C)Oc1cc(CNC(=O)NC[C@@H](O)C(C)(C)C)ccn1 by adding a hydroxyl.,CC(C)(C)Oc1cc(CNC(=O)NC[C@@H](O)C(C)(C)C)ccn1,hydroxyl
100253,Add a carboxyl to the molecule CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O.,CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O,carboxyl
158496,Please add a benzene ring to the molecule COc1cccc([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]nc(O)c32)c1OC.,COc1cccc([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]nc(O)c32)c1OC,benzene ring
9182,Add a benzene ring to the molecule O=C(c1scnc1C1CC1)N1CCO[C@@H](c2ccsc2)C1.,O=C(c1scnc1C1CC1)N1CCO[C@@H](c2ccsc2)C1,benzene ring
71006,Add a nitrile to the molecule CCCOc1ccc(C(F)(F)F)cc1NC(=O)c1cccc(N2CCOC2=O)c1.,CCCOc1ccc(C(F)(F)F)cc1NC(=O)c1cccc(N2CCOC2=O)c1,nitrile
64716,Modify the molecule C[C@H](C(=O)Nc1ccc2c(c1)nc(C1CC1)n2C)c1ccccc1F by adding a thiol.,C[C@H](C(=O)Nc1ccc2c(c1)nc(C1CC1)n2C)c1ccccc1F,thiol
112449,Add a amide to the molecule CC(C)Sc1ccccc1C(=O)N(C)C1CCOCC1.,CC(C)Sc1ccccc1C(=O)N(C)C1CCOCC1,amide
21579,Add a halo to the molecule COc1cc(-c2nnc3n(Cc4ccccc4)c(=O)c4ccccc4n23)cc(OC)c1O.,COc1cc(-c2nnc3n(Cc4ccccc4)c(=O)c4ccccc4n23)cc(OC)c1O,halo
159960,Add a hydroxyl to the molecule CCC1(CC)CC[NH+]([C@]2(C[NH3+])CCCS[C@H]2C)CC1.,CCC1(CC)CC[NH+]([C@]2(C[NH3+])CCCS[C@H]2C)CC1,hydroxyl
14196,Modify the molecule CC[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](CC)c1ccc(C)cc1 by adding a nitro.,CC[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](CC)c1ccc(C)cc1,nitro
14675,Add a carboxyl to the molecule Cc1ccc2[nH]c(C(=O)[O-])c(NC(=O)[C@H]3C[C@H]3c3ccccc3)c2c1.,Cc1ccc2[nH]c(C(=O)[O-])c(NC(=O)[C@H]3C[C@H]3c3ccccc3)c2c1,carboxyl
242267,Please add a hydroxyl to the molecule C[C@H]1CN(S(=O)(=O)c2cccc(C(=O)NC3(C(=O)[O-])CCCCC3)c2)C[C@H](C)O1.,C[C@H]1CN(S(=O)(=O)c2cccc(C(=O)NC3(C(=O)[O-])CCCCC3)c2)C[C@H](C)O1,hydroxyl
216034,Modify the molecule C[C@@H]1CO[C@@H](CO)CN1Cc1c[nH]nc1-c1ccc2c(c1)OCCO2 by adding a amide.,C[C@@H]1CO[C@@H](CO)CN1Cc1c[nH]nc1-c1ccc2c(c1)OCCO2,amide
8508,Add a aldehyde to the molecule Cc1c(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(=O)n(C)c(=O)n1-c1ccccc1.,Cc1c(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(=O)n(C)c(=O)n1-c1ccccc1,aldehyde
93841,Please add a aldehyde to the molecule C=CCn1c(O)nc(O)c([C@H]2[NH2+]CCc3c2[nH]c2ccc(OC)cc32)c1=O.,C=CCn1c(O)nc(O)c([C@H]2[NH2+]CCc3c2[nH]c2ccc(OC)cc32)c1=O,aldehyde
36006,Please add a nitro to the molecule COc1ccc(C(=O)COc2ccc3c(c2C)O/C(=C\c2ccccc2OC)C3=O)cc1.,COc1ccc(C(=O)COc2ccc3c(c2C)O/C(=C\c2ccccc2OC)C3=O)cc1,nitro
78996,Please add a amide to the molecule COc1ccc(CNC(=O)C2CC[NH+](Cc3ccc(C#N)o3)CC2)cc1.,COc1ccc(CNC(=O)C2CC[NH+](Cc3ccc(C#N)o3)CC2)cc1,amide
199799,Please add a benzene ring to the molecule O=C(Cc1ccccc1NC(=O)c1cccc2ccoc12)NC1CCCC1.,O=C(Cc1ccccc1NC(=O)c1cccc2ccoc12)NC1CCCC1,benzene ring
198897,Please add a aldehyde to the molecule CCc1nc(NCC2CC2)nc(OCC(=O)[O-])c1C.,CCc1nc(NCC2CC2)nc(OCC(=O)[O-])c1C,aldehyde
185171,Please add a amide to the molecule Cc1cccc(NC(=O)c2cc3n(n2)[C@@H](C(F)(F)F)C[C@@H](c2ccc4c(c2)OCO4)N3)c1.,Cc1cccc(NC(=O)c2cc3n(n2)[C@@H](C(F)(F)F)C[C@@H](c2ccc4c(c2)OCO4)N3)c1,amide
76776,Modify the molecule COc1ccc(-n2nnc(-c3nsc(NC(=O)c4cccc(F)c4)n3)c2C)cc1OC by adding a amine.,COc1ccc(-n2nnc(-c3nsc(NC(=O)c4cccc(F)c4)n3)c2C)cc1OC,amine
97773,Modify the molecule O=C1ON=C(c2ccc(Cl)cc2)/C1=C/c1ccccc1OS(=O)(=O)c1ccccc1 by adding a hydroxyl.,O=C1ON=C(c2ccc(Cl)cc2)/C1=C/c1ccccc1OS(=O)(=O)c1ccccc1,hydroxyl
111883,Add a hydroxyl to the molecule c1ccc(-c2nc(CNc3ccc(O[C@H]4CCOC4)cc3)no2)cc1.,c1ccc(-c2nc(CNc3ccc(O[C@H]4CCOC4)cc3)no2)cc1,hydroxyl
150704,Add a benzene ring to the molecule O=C(COC(=O)c1nc(Cl)ccc1Cl)NC(=O)NC1CCCCC1.,O=C(COC(=O)c1nc(Cl)ccc1Cl)NC(=O)NC1CCCCC1,benzene ring
140595,Modify the molecule CC1CCN(C(=O)c2cccc(S(=O)(=O)NC[C@@H]3CCCO3)c2)CC1 by adding a benzene ring.,CC1CCN(C(=O)c2cccc(S(=O)(=O)NC[C@@H]3CCCO3)c2)CC1,benzene ring
50272,Please add a hydroxyl to the molecule COCCN1C[C@H]2CC[C@@H]1C[NH+](Cc1ccc(-c3cc[nH]n3)o1)C2.,COCCN1C[C@H]2CC[C@@H]1C[NH+](Cc1ccc(-c3cc[nH]n3)o1)C2,hydroxyl
64184,Add a hydroxyl to the molecule Cc1nnc(N2CCCN(c3ncccc3C#N)CC2)s1.,Cc1nnc(N2CCCN(c3ncccc3C#N)CC2)s1,hydroxyl
179899,Please add a carboxyl to the molecule O=C(Cc1ccc(F)c(F)c1)N1CCS[C@@H](c2ccccc2)C1.,O=C(Cc1ccc(F)c(F)c1)N1CCS[C@@H](c2ccccc2)C1,carboxyl
59871,Modify the molecule Cc1cnc([C@H](C)NC(=O)N[C@@H]2C[C@@H]2C2CCCCC2)s1 by adding a benzene ring.,Cc1cnc([C@H](C)NC(=O)N[C@@H]2C[C@@H]2C2CCCCC2)s1,benzene ring
48924,Add a hydroxyl to the molecule CSCc1ccnc(N[C@H]2CCc3cc(F)ccc32)c1.,CSCc1ccnc(N[C@H]2CCc3cc(F)ccc32)c1,hydroxyl
90223,Please add a carboxyl to the molecule CC(C)Oc1ccc(CNc2cnn(CC(=O)N3CCOCC3)c2)cc1.,CC(C)Oc1ccc(CNc2cnn(CC(=O)N3CCOCC3)c2)cc1,carboxyl
175543,Please add a nitro to the molecule O=C(NCC#CCOc1cccc(Br)c1)[C@H]1CC(=O)N(c2ccc(F)cc2)C1.,O=C(NCC#CCOc1cccc(Br)c1)[C@H]1CC(=O)N(c2ccc(F)cc2)C1,nitro
116810,Modify the molecule C#Cc1cc(F)c(NC(=O)N(C)C[C@H](O)CN2CCOCC2)c(F)c1 by adding a hydroxyl.,C#Cc1cc(F)c(NC(=O)N(C)C[C@H](O)CN2CCOCC2)c(F)c1,hydroxyl
122493,Modify the molecule COC(=O)c1ccccc1-c1ccsc1 by adding a halo.,COC(=O)c1ccccc1-c1ccsc1,halo
137966,Please add a halo to the molecule C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO.,C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO,halo
112802,Modify the molecule CC[C@H]1CCCCN1C(=O)c1ccc(S(=O)(=O)N2C[C@@H](C)C[C@@H](C)C2)cc1 by adding a amide.,CC[C@H]1CCCCN1C(=O)c1ccc(S(=O)(=O)N2C[C@@H](C)C[C@@H](C)C2)cc1,amide
148020,Modify the molecule CC(=O)Nc1ccc(/C(C#N)=C/c2ccc(N(C)CCC#N)cc2)cc1 by adding a benzene ring.,CC(=O)Nc1ccc(/C(C#N)=C/c2ccc(N(C)CCC#N)cc2)cc1,benzene ring
244636,Add a nitro to the molecule O=C1CCCC[C@H]1[C@@H]1CCCCN1C(=O)[C@@H]1CCCO1.,O=C1CCCC[C@H]1[C@@H]1CCCCN1C(=O)[C@@H]1CCCO1,nitro
194596,Modify the molecule Cn1cc(C(=O)NNC(=O)CCSc2ccc(F)cc2)c(C(C)(C)C)n1 by adding a halo.,Cn1cc(C(=O)NNC(=O)CCSc2ccc(F)cc2)c(C(C)(C)C)n1,halo
225951,Modify the molecule N#Cc1ccncc1NCCCOc1ncc(C(F)(F)F)cc1Cl by adding a amine.,N#Cc1ccncc1NCCCOc1ncc(C(F)(F)F)cc1Cl,amine
209037,Please add a halo to the molecule C[C@](O)(C(=O)N/N=C/c1ccccc1)c1ccccc1.,C[C@](O)(C(=O)N/N=C/c1ccccc1)c1ccccc1,halo
198679,Modify the molecule C[C@@H]1CC[C@@]2(CC(=O)NC(=O)[C@@H]2c2ccc(Cl)cc2)C1 by adding a nitro.,C[C@@H]1CC[C@@]2(CC(=O)NC(=O)[C@@H]2c2ccc(Cl)cc2)C1,nitro
77827,Add a carboxyl to the molecule COc1cc(NC(=S)NC(=O)c2cccc(Cl)c2)ccc1NC(=O)C(C)C.,COc1cc(NC(=S)NC(=O)c2cccc(Cl)c2)ccc1NC(=O)C(C)C,carboxyl
128160,Add a hydroxyl to the molecule C[C@H]1CCCN(c2ccc(C(=O)O[C@@H](C)C(N)=O)cc2[N+](=O)[O-])C1.,C[C@H]1CCCN(c2ccc(C(=O)O[C@@H](C)C(N)=O)cc2[N+](=O)[O-])C1,hydroxyl
72639,Add a benzene ring to the molecule C[C@H](O)C[C@H](C)CNC(=O)c1cccc(F)c1Cl.,C[C@H](O)C[C@H](C)CNC(=O)c1cccc(F)c1Cl,benzene ring
18638,Modify the molecule CC(C)c1n[nH]c2c1[C@@H](c1ccc(F)c(Br)c1)C(C#N)=C(N)O2 by adding a amide.,CC(C)c1n[nH]c2c1[C@@H](c1ccc(F)c(Br)c1)C(C#N)=C(N)O2,amide
123177,Please add a benzene ring to the molecule CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2.,CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2,benzene ring
156760,Please add a hydroxyl to the molecule O=C(NCCN1CCOCC1)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1.,O=C(NCCN1CCOCC1)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1,hydroxyl
99588,Modify the molecule C=CCNC(=O)COc1c(F)cc(CO)cc1F by adding a hydroxyl.,C=CCNC(=O)COc1c(F)cc(CO)cc1F,hydroxyl
133323,Please add a amide to the molecule CC[NH+](CC(=O)NC(C)C)[C@H]1CCCC(=O)C1.,CC[NH+](CC(=O)NC(C)C)[C@H]1CCCC(=O)C1,amide
242419,Modify the molecule COc1cc(NC(=O)c2cccc(F)c2)ccc1NC(=O)C(C)C by adding a carboxyl.,COc1cc(NC(=O)c2cccc(F)c2)ccc1NC(=O)C(C)C,carboxyl
204765,Please add a benzene ring to the molecule COC(=O)NCc1ccc(NC(=O)N2CCC[C@H]3CCC[C@H]32)cc1.,COC(=O)NCc1ccc(NC(=O)N2CCC[C@H]3CCC[C@H]32)cc1,benzene ring
79676,Modify the molecule C[C@@H](C1CC1)N(C)C(=O)N[C@H](C)c1ccc(NC(=O)NC2CC2)cc1 by adding a nitro.,C[C@@H](C1CC1)N(C)C(=O)N[C@H](C)c1ccc(NC(=O)NC2CC2)cc1,nitro
20099,Modify the molecule O=C(Cn1c(-c2cscn2)nc2ccccc21)NC[C@@H]1CCCO1 by adding a amide.,O=C(Cn1c(-c2cscn2)nc2ccccc21)NC[C@@H]1CCCO1,amide
126561,Modify the molecule Cc1ccc(Oc2ccc(NC(=O)NC3CCC(O)CC3)cc2)cc1 by adding a amide.,Cc1ccc(Oc2ccc(NC(=O)NC3CCC(O)CC3)cc2)cc1,amide
111219,Modify the molecule COc1cc([N+](=O)[O-])ccc1OCC(=O)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1 by adding a hydroxyl.,COc1cc([N+](=O)[O-])ccc1OCC(=O)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1,hydroxyl
171340,Modify the molecule Cn1cc(C(=O)N2CCCC2)cc(NC(=O)CCc2ccccc2)c1=O by adding a nitro.,Cn1cc(C(=O)N2CCCC2)cc(NC(=O)CCc2ccccc2)c1=O,nitro
129360,Modify the molecule CNc1cc(C)c(S(=O)(=O)N2CCCCC2)cc1[N+](=O)[O-] by adding a aldehyde.,CNc1cc(C)c(S(=O)(=O)N2CCCCC2)cc1[N+](=O)[O-],aldehyde
219588,Modify the molecule O=C(NC[C@H]1CCO[C@@H]1c1ccccc1)N(Cc1ccccc1)C1CC1 by adding a benzene ring.,O=C(NC[C@H]1CCO[C@@H]1c1ccccc1)N(Cc1ccccc1)C1CC1,benzene ring
199681,Modify the molecule COc1ccc2c(c1)C=C(C(=O)NCCc1cccc(C(N)=O)c1)CO2 by adding a benzene ring.,COc1ccc2c(c1)C=C(C(=O)NCCc1cccc(C(N)=O)c1)CO2,benzene ring
102122,Please add a amine to the molecule O=C(/C=C/c1ccccc1)Nc1nc(CC(=O)N2CCN(C(=O)[C@@H]3CCCO3)CC2)cs1.,O=C(/C=C/c1ccccc1)Nc1nc(CC(=O)N2CCN(C(=O)[C@@H]3CCCO3)CC2)cs1,amine
4707,Modify the molecule Cc1cccc(NC(=O)CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(F)cc3)cc2)c1C by adding a halo.,Cc1cccc(NC(=O)CNC(=O)c2ccc(S(=O)(=O)Nc3ccc(F)cc3)cc2)c1C,halo
19197,Modify the molecule CCN(CC)C(=O)c1cn(C2CCC(NC(=O)C(C)(C)C)CC2)nn1 by adding a aldehyde.,CCN(CC)C(=O)c1cn(C2CCC(NC(=O)C(C)(C)C)CC2)nn1,aldehyde
64352,Please add a halo to the molecule NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1.,NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1,halo
113064,Modify the molecule COc1ccc(CCC2CCN(C(=O)CNC(=O)c3ccccc3Cl)CC2)cc1 by adding a benzene ring.,COc1ccc(CCC2CCN(C(=O)CNC(=O)c3ccccc3Cl)CC2)cc1,benzene ring
81295,Add a amide to the molecule COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](c1ccc(F)cc1)N1Cc2ccccc2C1=O.,COc1cc(Cl)c(C)cc1NC(=O)C[C@@H](c1ccc(F)cc1)N1Cc2ccccc2C1=O,amide
161017,Modify the molecule Cc1cccc2nc[nH+]c(N3CCN(c4ccc(F)cn4)CC3)c12 by adding a hydroxyl.,Cc1cccc2nc[nH+]c(N3CCN(c4ccc(F)cn4)CC3)c12,hydroxyl
180884,Please add a benzene ring to the molecule Cc1ccc(-n2c(C)c(C[NH2+]Cc3ccc(F)cc3)c(C(=O)[O-])c2C)cc1.,Cc1ccc(-n2c(C)c(C[NH2+]Cc3ccc(F)cc3)c(C(=O)[O-])c2C)cc1,benzene ring
203395,Add a nitro to the molecule O=C(NCC(=O)N1CCC(Cc2ccccc2)CC1)c1cnn[nH]1.,O=C(NCC(=O)N1CCC(Cc2ccccc2)CC1)c1cnn[nH]1,nitro
225917,Please add a amide to the molecule CCc1nn(CC)c(CC)c1C[NH3+].,CCc1nn(CC)c(CC)c1C[NH3+],amide
11571,Please add a benzene ring to the molecule CNC(=O)[C@@H]1CCC[NH+]1CC(C)(C)C(=O)OC.,CNC(=O)[C@@H]1CCC[NH+]1CC(C)(C)C(=O)OC,benzene ring
205859,Add a aldehyde to the molecule CC(C)CC1=NN=C2CCN(C(=O)c3ccc4c(c3)CCO4)C[C@H]21.,CC(C)CC1=NN=C2CCN(C(=O)c3ccc4c(c3)CCO4)C[C@H]21,aldehyde
235612,Please add a nitro to the molecule CC(C)[C@@H]1C[C@](CC#N)(c2ccccc2)CCO1.,CC(C)[C@@H]1C[C@](CC#N)(c2ccccc2)CCO1,nitro
36871,Please add a benzene ring to the molecule Cc1ccc([C@@H]2CCCCCN2C(=O)[C@H](O)c2ccccc2)o1.,Cc1ccc([C@@H]2CCCCCN2C(=O)[C@H](O)c2ccccc2)o1,benzene ring
135363,Add a amide to the molecule CC1CCN(c2ccc(C(=O)N3CCN(c4ccc(C(F)(F)F)cn4)CC3)cc2[N+](=O)[O-])CC1.,CC1CCN(c2ccc(C(=O)N3CCN(c4ccc(C(F)(F)F)cn4)CC3)cc2[N+](=O)[O-])CC1,amide
87122,Modify the molecule C[C@@H](NCCc1cn2ccccc2n1)c1nc2c(s1)CCCC2 by adding a nitro.,C[C@@H](NCCc1cn2ccccc2n1)c1nc2c(s1)CCCC2,nitro
76881,Please add a aldehyde to the molecule Nc1c(N2CCN(c3ccc(F)cc3)CC2)ncnc1N1CCN(c2ccccc2F)CC1.,Nc1c(N2CCN(c3ccc(F)cc3)CC2)ncnc1N1CCN(c2ccccc2F)CC1,aldehyde
199423,Add a benzene ring to the molecule COc1ccc(Cl)cc1/N=C1/S[C@H](CC(=O)Nc2c(C)cccc2C)C(=O)N1C.,COc1ccc(Cl)cc1/N=C1/S[C@H](CC(=O)Nc2c(C)cccc2C)C(=O)N1C,benzene ring
126073,Please add a amide to the molecule COc1ccc2c(c1)CN(Cc1cnnn1C)[C@@H](c1ccccc1)C2.,COc1ccc2c(c1)CN(Cc1cnnn1C)[C@@H](c1ccccc1)C2,amide
154225,Modify the molecule COC(=O)C(=O)N1CC[C@H]2NC(=O)N(c3ccc(C)cc3)C(=O)[C@H]21 by adding a carboxyl.,COC(=O)C(=O)N1CC[C@H]2NC(=O)N(c3ccc(C)cc3)C(=O)[C@H]21,carboxyl
17217,Please add a amide to the molecule NC(=O)N1CCC[C@@H](C(=O)N[C@H]2CCSc3c(F)cccc32)C1.,NC(=O)N1CCC[C@@H](C(=O)N[C@H]2CCSc3c(F)cccc32)C1,amide
195560,Please add a hydroxyl to the molecule Cc1nc([C@@H]2CCCN(C(=O)c3cccc4ncccc34)C2)ncc1C(=O)N1CCOCC1.,Cc1nc([C@@H]2CCCN(C(=O)c3cccc4ncccc34)C2)ncc1C(=O)N1CCOCC1,hydroxyl
83067,Add a hydroxyl to the molecule Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O.,Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O,hydroxyl
20002,Modify the molecule O=C(NCc1ccccc1F)NC[C@H]1CC[NH+](CC(F)(F)F)C1 by adding a hydroxyl.,O=C(NCc1ccccc1F)NC[C@H]1CC[NH+](CC(F)(F)F)C1,hydroxyl
134107,Modify the molecule COc1ccccc1[C@@H](C#N)NC(=O)CCOc1c(C)cccc1C by adding a amide.,COc1ccccc1[C@@H](C#N)NC(=O)CCOc1c(C)cccc1C,amide
73837,Modify the molecule C[C@@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccccc2N2CCCC2)C1 by adding a benzene ring.,C[C@@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccccc2N2CCCC2)C1,benzene ring
33967,Add a benzene ring to the molecule Cc1nn(CCCC(=O)N[C@H]2CCCC[C@@H]2C)c(=O)c2c1sc1ccccc12.,Cc1nn(CCCC(=O)N[C@H]2CCCC[C@@H]2C)c(=O)c2c1sc1ccccc12,benzene ring
167136,Please add a carboxyl to the molecule C[C@H](NC(=O)CCOc1cccc(C=O)c1)c1ccc(Cl)s1.,C[C@H](NC(=O)CCOc1cccc(C=O)c1)c1ccc(Cl)s1,carboxyl
158423,Modify the molecule C[C@H](N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1)c1cncc(F)c1 by adding a benzene ring.,C[C@H](N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1)c1cncc(F)c1,benzene ring
139115,Modify the molecule CC[C@H](CO)NC(=O)c1csc(-c2ccc(Cl)cc2)n1 by adding a carboxyl.,CC[C@H](CO)NC(=O)c1csc(-c2ccc(Cl)cc2)n1,carboxyl
81964,Add a benzene ring to the molecule CCS(=O)(=O)c1ccc2oc(SCC(=O)N3C[C@H](C)O[C@H](C)C3)nc2c1.,CCS(=O)(=O)c1ccc2oc(SCC(=O)N3C[C@H](C)O[C@H](C)C3)nc2c1,benzene ring
206814,Add a amine to the molecule O=C(c1cc2c([nH]c1=O)CCCC2)N1CCC[C@H](OCc2ccccn2)C1.,O=C(c1cc2c([nH]c1=O)CCCC2)N1CCC[C@H](OCc2ccccn2)C1,amine
210806,Please add a hydroxyl to the molecule CC(=O)Nc1cc(C(=O)Nc2ccc(C(C)=O)c(C)c2)ccc1F.,CC(=O)Nc1cc(C(=O)Nc2ccc(C(C)=O)c(C)c2)ccc1F,hydroxyl
174651,Modify the molecule CCn1c(SCC(=O)N2CCN(c3ccc(OC)cc3)CC2)nnc1-c1ccco1 by adding a hydroxyl.,CCn1c(SCC(=O)N2CCN(c3ccc(OC)cc3)CC2)nnc1-c1ccco1,hydroxyl
146571,Please add a carboxyl to the molecule O=C(c1ccc(-c2ccco2)[nH]c1=O)N1CC[C@@H]1c1ccccc1.,O=C(c1ccc(-c2ccco2)[nH]c1=O)N1CC[C@@H]1c1ccccc1,carboxyl
194393,Modify the molecule Nc1ccc(OCc2nccs2)cc1Cl by adding a benzene ring.,Nc1ccc(OCc2nccs2)cc1Cl,benzene ring
194380,Please add a halo to the molecule Cc1ccc(CC(=O)NCc2nc(-c3cccc(Br)c3)no2)cc1C.,Cc1ccc(CC(=O)NCc2nc(-c3cccc(Br)c3)no2)cc1C,halo
157704,Please add a benzene ring to the molecule Cc1ccc(C(=O)N[C@@H]2N=C3[C@H](CC[C@@H]3C(=O)NCCc3c[nH]c4ccccc34)S2)cc1.,Cc1ccc(C(=O)N[C@@H]2N=C3[C@H](CC[C@@H]3C(=O)NCCc3c[nH]c4ccccc34)S2)cc1,benzene ring
192440,Modify the molecule CC[C@@H](C)C[C@@H](C)NC(=O)N1CCC([C@@H](C)O)CC1 by adding a benzene ring.,CC[C@@H](C)C[C@@H](C)NC(=O)N1CCC([C@@H](C)O)CC1,benzene ring
165380,Add a benzene ring to the molecule COc1cccc([C@H]2C3=C(CCCC3=O)Nc3nnnn32)c1OC(C)C.,COc1cccc([C@H]2C3=C(CCCC3=O)Nc3nnnn32)c1OC(C)C,benzene ring
233355,Add a nitro to the molecule CCc1ccc(C(=O)N(CCC#N)CC2CC2)cc1.,CCc1ccc(C(=O)N(CCC#N)CC2CC2)cc1,nitro
137551,Add a nitro to the molecule [NH3+][C@@](Cc1ccc(F)cc1)(C(=O)[O-])c1ccccc1.,[NH3+][C@@](Cc1ccc(F)cc1)(C(=O)[O-])c1ccccc1,nitro
186785,Modify the molecule Cc1cc(C)c(C(=O)Nc2cccc([S@@](C)=O)c2)c(C)c1 by adding a hydroxyl.,Cc1cc(C)c(C(=O)Nc2cccc([S@@](C)=O)c2)c(C)c1,hydroxyl
166655,Please add a hydroxyl to the molecule O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1.,O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1,hydroxyl
91097,Add a amide to the molecule COCC[C@@H](C)C(=O)Nc1ccc(Br)cc1.,COCC[C@@H](C)C(=O)Nc1ccc(Br)cc1,amide
228563,Please add a amine to the molecule COCc1c(Cl)cccc1NC(=O)N[C@@H](C)c1ccc(Cl)s1.,COCc1c(Cl)cccc1NC(=O)N[C@@H](C)c1ccc(Cl)s1,amine
18611,Modify the molecule Cc1nc(C)n(-c2ccc(C(=O)NC[C@H](C)[NH+]3CCC(C)CC3)cc2)n1 by adding a nitrile.,Cc1nc(C)n(-c2ccc(C(=O)NC[C@H](C)[NH+]3CCC(C)CC3)cc2)n1,nitrile
27011,Please add a carboxyl to the molecule CC(C)CNC(=O)[C@@H](C)SCc1coc(-c2ccc(Cl)cc2)n1.,CC(C)CNC(=O)[C@@H](C)SCc1coc(-c2ccc(Cl)cc2)n1,carboxyl
117132,Add a amine to the molecule C#CCNC(=O)[C@]1(Cc2ccccc2-c2cccnc2)CCN(C(=O)[C@H]2CCCO2)C1.,C#CCNC(=O)[C@]1(Cc2ccccc2-c2cccnc2)CCN(C(=O)[C@H]2CCCO2)C1,amine
45945,Modify the molecule C[C@H](C(=O)NCc1cccc(COC2CCOCC2)c1)[NH+]1CCCCCC1 by adding a aldehyde.,C[C@H](C(=O)NCc1cccc(COC2CCOCC2)c1)[NH+]1CCCCCC1,aldehyde
29330,Add a hydroxyl to the molecule Cn1ncc2c(N3CCN(Cc4cccc5ccccc45)CC3)ncnc21.,Cn1ncc2c(N3CCN(Cc4cccc5ccccc45)CC3)ncnc21,hydroxyl
230540,Modify the molecule Cc1ccc(Sc2ccc(NC(=O)CNC(=O)c3cc([N+](=O)[O-])cn3C)cc2)cc1C by adding a amide.,Cc1ccc(Sc2ccc(NC(=O)CNC(=O)c3cc([N+](=O)[O-])cn3C)cc2)cc1C,amide
40546,Please add a aldehyde to the molecule CNc1nc(Cc2ccc(OC)nc2)ns1.,CNc1nc(Cc2ccc(OC)nc2)ns1,aldehyde
235778,Add a benzene ring to the molecule CC(C)c1c(N)nnn1CCOc1ccccc1Cl.,CC(C)c1c(N)nnn1CCOc1ccccc1Cl,benzene ring
75373,Modify the molecule COCCNC(=O)CNC(=O)NCc1ccc(C)cc1 by adding a hydroxyl.,COCCNC(=O)CNC(=O)NCc1ccc(C)cc1,hydroxyl
193870,Add a hydroxyl to the molecule CC(C)c1ccccc1NC(=O)N[C@H](C)c1ccc(NC(=O)C2CC2)cc1.,CC(C)c1ccccc1NC(=O)N[C@H](C)c1ccc(NC(=O)C2CC2)cc1,hydroxyl
9245,Modify the molecule COc1ccccc1CN1C(=O)c2cc3ccsc3n2C[C@]1(C)C(=O)NCc1ccc(F)cc1 by adding a halo.,COc1ccccc1CN1C(=O)c2cc3ccsc3n2C[C@]1(C)C(=O)NCc1ccc(F)cc1,halo
19370,Modify the molecule Cc1cncc(NC(=O)C(=O)NCc2ccc(Br)cc2)c1 by adding a amine.,Cc1cncc(NC(=O)C(=O)NCc2ccc(Br)cc2)c1,amine
50485,Please add a aldehyde to the molecule C[C@H](Sc1nc(-c2ccccc2F)n[nH]1)C(=O)N[C@@H](C)c1ccc(F)cc1.,C[C@H](Sc1nc(-c2ccccc2F)n[nH]1)C(=O)N[C@@H](C)c1ccc(F)cc1,aldehyde
24030,Please add a benzene ring to the molecule COc1cccc(CNC(=O)N[C@H](C)c2ccc(Cl)s2)n1.,COc1cccc(CNC(=O)N[C@H](C)c2ccc(Cl)s2)n1,benzene ring
150027,Modify the molecule COc1ccc2c(c1)C=C(C(=O)N(Cc1ccccc1)[C@H](C)CCO)CO2 by adding a hydroxyl.,COc1ccc2c(c1)C=C(C(=O)N(Cc1ccccc1)[C@H](C)CCO)CO2,hydroxyl
237383,Modify the molecule C[C@H]1SC[C@H](C(=O)[O-])N1C(=O)[C@@H]1CSc2ccccc21 by adding a nitro.,C[C@H]1SC[C@H](C(=O)[O-])N1C(=O)[C@@H]1CSc2ccccc21,nitro
120126,Add a amine to the molecule CC[NH+](CC)C(C)(C)C(=O)c1ccc(C(C)C)cc1.,CC[NH+](CC)C(C)(C)C(=O)c1ccc(C(C)C)cc1,amine
165592,Add a carboxyl to the molecule CC(C)NC(=O)CNC(=O)c1cc(-c2ccccc2)nc2c1cnn2Cc1cccc(F)c1.,CC(C)NC(=O)CNC(=O)c1cc(-c2ccccc2)nc2c1cnn2Cc1cccc(F)c1,carboxyl
32440,Add a benzene ring to the molecule O=C(Nc1ccccc1)C1CCN(C(=O)c2nc3c(F)cccc3s2)CC1.,O=C(Nc1ccccc1)C1CCN(C(=O)c2nc3c(F)cccc3s2)CC1,benzene ring
205914,Modify the molecule Cc1nc([O-])c2c(n1)C[NH+](Cc1cccn1Cc1ccccc1F)CC2 by adding a amine.,Cc1nc([O-])c2c(n1)C[NH+](Cc1cccn1Cc1ccccc1F)CC2,amine
90621,Please add a carboxyl to the molecule O=C(c1ccnc(OCC(F)F)c1)N1CCC[C@@H]1c1ccc(O)cc1.,O=C(c1ccnc(OCC(F)F)c1)N1CCC[C@@H]1c1ccc(O)cc1,carboxyl
132967,Add a amine to the molecule CC(C)[C@@H]1C[C@@H](NC(=O)CCN2C(=O)COc3ccccc32)CCO1.,CC(C)[C@@H]1C[C@@H](NC(=O)CCN2C(=O)COc3ccccc32)CCO1,amine
215733,Add a aldehyde to the molecule CNc1cc(C(=O)NCc2cccc(-c3n[nH]c(C)n3)c2)cc(Cl)n1.,CNc1cc(C(=O)NCc2cccc(-c3n[nH]c(C)n3)c2)cc(Cl)n1,aldehyde
69667,Add a hydroxyl to the molecule CCC[C@H]1C(=O)NC(=O)C[C@H]1C(CC)CC.,CCC[C@H]1C(=O)NC(=O)C[C@H]1C(CC)CC,hydroxyl
82137,Please add a hydroxyl to the molecule Cc1ccc(/C(N)=N/O)c(SC2COC2)n1.,Cc1ccc(/C(N)=N/O)c(SC2COC2)n1,hydroxyl
204590,Modify the molecule [NH3+]Cc1cc(F)ccc1CS(=O)(=O)c1cccc(F)c1 by adding a nitrile.,[NH3+]Cc1cc(F)ccc1CS(=O)(=O)c1cccc(F)c1,nitrile
228990,Please add a benzene ring to the molecule CCN1CC[C@@]2(CCC1=O)C[C@@H](NC(=O)c1ccncc1)c1ccccc1O2.,CCN1CC[C@@]2(CCC1=O)C[C@@H](NC(=O)c1ccncc1)c1ccccc1O2,benzene ring
197741,Add a amine to the molecule COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1.,COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1,amine
10648,Modify the molecule Cc1ncsc1C[NH+]1[C@@H](C)CC[C@@H]1C by adding a hydroxyl.,Cc1ncsc1C[NH+]1[C@@H](C)CC[C@@H]1C,hydroxyl
129338,Modify the molecule CCN(CC)C(=O)c1cccc(NC(=O)c2cc([N+](=O)[O-])ccc2N2CCCCC2)c1 by adding a carboxyl.,CCN(CC)C(=O)c1cccc(NC(=O)c2cc([N+](=O)[O-])ccc2N2CCCCC2)c1,carboxyl
160558,Please add a carboxyl to the molecule CCCNC(=O)c1cccc(CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)c1.,CCCNC(=O)c1cccc(CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)c1,carboxyl
32780,Add a benzene ring to the molecule COc1ccc(C(=O)NC[C@H]2C(=O)N=C(C)C=C2C)c(F)c1.,COc1ccc(C(=O)NC[C@H]2C(=O)N=C(C)C=C2C)c(F)c1,benzene ring
215679,Add a benzene ring to the molecule CCc1nn(C)c(OC)c1C[NH+](C)[C@@H](C)[C@@H]1Cc2ccccc2O1.,CCc1nn(C)c(OC)c1C[NH+](C)[C@@H](C)[C@@H]1Cc2ccccc2O1,benzene ring
188660,Modify the molecule O=C(NC1CC1)c1ccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)CCCC3)cc1 by adding a carboxyl.,O=C(NC1CC1)c1ccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)CCCC3)cc1,carboxyl
77994,Add a benzene ring to the molecule CCc1ccccc1NS(=O)(=O)c1ccc(OC)c(C)c1.,CCc1ccccc1NS(=O)(=O)c1ccc(OC)c(C)c1,benzene ring
40158,Add a aldehyde to the molecule C[C@H]1[C@@H](C(=O)[O-])CCN1C(=O)c1cc2cc(F)ccc2s1.,C[C@H]1[C@@H](C(=O)[O-])CCN1C(=O)c1cc2cc(F)ccc2s1,aldehyde
159601,Modify the molecule CC1(C)[C@@H]2C/C(=N\O)[C@](C)([NH2+]Cc3ccccc3)[C@H]1C2 by adding a benzene ring.,CC1(C)[C@@H]2C/C(=N\O)[C@](C)([NH2+]Cc3ccccc3)[C@H]1C2,benzene ring
54827,Modify the molecule Cc1nc(/C=C/C(=O)N2CCN(c3nccs3)CC2)cs1 by adding a benzene ring.,Cc1nc(/C=C/C(=O)N2CCN(c3nccs3)CC2)cs1,benzene ring
80769,Please add a benzene ring to the molecule COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)OCC(F)(F)F.,COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)OCC(F)(F)F,benzene ring
181418,Add a amide to the molecule CC1=C[C@@H]2C=c3ccccc3=C2C=C1.,CC1=C[C@@H]2C=c3ccccc3=C2C=C1,amide
135082,Modify the molecule C[C@H](Sc1ccccc1Cl)C(=O)Nc1nc(-c2cccnc2)cs1 by adding a amine.,C[C@H](Sc1ccccc1Cl)C(=O)Nc1nc(-c2cccnc2)cs1,amine
211824,Add a hydroxyl to the molecule Fc1ccc(-c2ccc(/C=N/c3c(F)c(F)c(F)c(F)c3F)[nH]2)cc1.,Fc1ccc(-c2ccc(/C=N/c3c(F)c(F)c(F)c(F)c3F)[nH]2)cc1,hydroxyl
161224,Please add a amide to the molecule CC[C@@H](CC[NH3+])CCC(=O)N[C@@H]1CCCCC1(C)C.,CC[C@@H](CC[NH3+])CCC(=O)N[C@@H]1CCCCC1(C)C,amide
7196,Please add a benzene ring to the molecule O=C(C[N-]C1=NC(Cl)=N[C@H]2N=CN=C12)NCCN1CCOCC1.,O=C(C[N-]C1=NC(Cl)=N[C@H]2N=CN=C12)NCCN1CCOCC1,benzene ring
161293,Add a nitro to the molecule Cc1nn(C)c(C)c1C[C@H](C)NC(=O)c1cccc(OCC(F)F)n1.,Cc1nn(C)c(C)c1C[C@H](C)NC(=O)c1cccc(OCC(F)F)n1,nitro
56797,Please add a amine to the molecule C[C@H]([NH2+][C@@H]1CCOC2(CCCCC2)C1)C(N)=O.,C[C@H]([NH2+][C@@H]1CCOC2(CCCCC2)C1)C(N)=O,amine
220742,Modify the molecule C[C@H](Oc1cccc(C=O)c1)C(=O)N1CCN(Cc2ccncc2)CC1 by adding a amide.,C[C@H](Oc1cccc(C=O)c1)C(=O)N1CCN(Cc2ccncc2)CC1,amide
25144,Modify the molecule COc1ccc(-c2noc(CN[C@@H](C3CCCC3)C(F)(F)F)n2)cc1 by adding a carboxyl.,COc1ccc(-c2noc(CN[C@@H](C3CCCC3)C(F)(F)F)n2)cc1,carboxyl
138202,Modify the molecule O=[N+]([O-])c1ccc(NC(C2CC2)C2CC2)c([N+](=O)[O-])c1 by adding a amide.,O=[N+]([O-])c1ccc(NC(C2CC2)C2CC2)c([N+](=O)[O-])c1,amide
223707,Add a benzene ring to the molecule CNC(=O)C(C)(C)CNC(=O)c1cccc(OC)c1F.,CNC(=O)C(C)(C)CNC(=O)c1cccc(OC)c1F,benzene ring
206807,Modify the molecule Cc1nnc(Nc2ccccn2)c2ccccc12 by adding a nitro.,Cc1nnc(Nc2ccccn2)c2ccccc12,nitro
187128,Add a carboxyl to the molecule Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1.,Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1,carboxyl
200909,Modify the molecule C=C(C)C[C@@H]([NH2+]CC)[C@@H]1CN2CCC[C@@H]2CO1 by adding a hydroxyl.,C=C(C)C[C@@H]([NH2+]CC)[C@@H]1CN2CCC[C@@H]2CO1,hydroxyl
119283,Modify the molecule CC(=O)c1ccc(NC(=O)CC[NH+]2CCN(Cc3ccc(Cl)s3)CC2)cc1 by adding a amide.,CC(=O)c1ccc(NC(=O)CC[NH+]2CCN(Cc3ccc(Cl)s3)CC2)cc1,amide
155518,Add a thiol to the molecule CN1C(=O)c2ccccc2Oc2ccc(C(=O)NC3CCCCC3)cc21.,CN1C(=O)c2ccccc2Oc2ccc(C(=O)NC3CCCCC3)cc21,thiol
17992,Add a benzene ring to the molecule Cc1ccn([C@H](C)CC(=O)Nc2ccccc2F)n1.,Cc1ccn([C@H](C)CC(=O)Nc2ccccc2F)n1,benzene ring
138905,Please add a hydroxyl to the molecule CCCC[C@@H]1CCC[C@H]1NC(=O)C(=O)Nc1nnc(C(F)(F)F)s1.,CCCC[C@@H]1CCC[C@H]1NC(=O)C(=O)Nc1nnc(C(F)(F)F)s1,hydroxyl
14292,Please add a nitro to the molecule CC(C)(C)CC(=O)N1CSC[C@H]1C(=O)NCc1ccc(F)cc1.,CC(C)(C)CC(=O)N1CSC[C@H]1C(=O)NCc1ccc(F)cc1,nitro
184246,Add a hydroxyl to the molecule Cc1nn(CCCl)c(C)c1C(=O)NNC(=O)Cc1ccccc1F.,Cc1nn(CCCl)c(C)c1C(=O)NNC(=O)Cc1ccccc1F,hydroxyl
47162,Please add a halo to the molecule C/C(=N\O)c1ccc(N2C(=O)[C@H]3CC=C(Cl)C[C@H]3C2=O)cc1.,C/C(=N\O)c1ccc(N2C(=O)[C@H]3CC=C(Cl)C[C@H]3C2=O)cc1,halo
120982,Modify the molecule Cc1nc(C(F)(F)F)nc(N2CCN[C@H](C(=O)NC3CC3)C2)c1C by adding a amide.,Cc1nc(C(F)(F)F)nc(N2CCN[C@H](C(=O)NC3CC3)C2)c1C,amide
172230,Modify the molecule C[C@H]1CCN(C(=O)Nc2ccn([C@@H](C)c3ccccc3)n2)[C@@H](C)C1 by adding a benzene ring.,C[C@H]1CCN(C(=O)Nc2ccn([C@@H](C)c3ccccc3)n2)[C@@H](C)C1,benzene ring
221425,Please add a nitro to the molecule Nc1cc(-c2ccccc2)nn1S(=O)(=O)c1ccc(C2CCCCC2)cc1.,Nc1cc(-c2ccccc2)nn1S(=O)(=O)c1ccc(C2CCCCC2)cc1,nitro
39815,Add a hydroxyl to the molecule CN(C(=O)CC1([NH3+])CCC1)c1ccc([N+](=O)[O-])cc1.,CN(C(=O)CC1([NH3+])CCC1)c1ccc([N+](=O)[O-])cc1,hydroxyl
7071,Modify the molecule COCCN1C[C@]2(CCC[NH+](Cc3ccc(SC)cc3)C2)CCC1=O by adding a hydroxyl.,COCCN1C[C@]2(CCC[NH+](Cc3ccc(SC)cc3)C2)CCC1=O,hydroxyl
51488,Modify the molecule N#Cc1ccccc1CSc1nnc(COc2ccc(Cl)cc2)o1 by adding a amide.,N#Cc1ccccc1CSc1nnc(COc2ccc(Cl)cc2)o1,amide
112152,Add a hydroxyl to the molecule CCOc1ccc(-n2c(CN[C@H](C)c3ccc4c(c3)OCCO4)nc3ccccc3c2=O)cc1.,CCOc1ccc(-n2c(CN[C@H](C)c3ccc4c(c3)OCCO4)nc3ccccc3c2=O)cc1,hydroxyl
204308,Please add a benzene ring to the molecule N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1.,N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1,benzene ring
158288,Please add a aldehyde to the molecule CC[C@H](C)N(CC)S(N)(=O)=O.,CC[C@H](C)N(CC)S(N)(=O)=O,aldehyde
231783,Modify the molecule CCc1ccc(O[C@@H]2CCC[C@@]([NH2+]C)(C(N)=O)C2)cc1 by adding a carboxyl.,CCc1ccc(O[C@@H]2CCC[C@@]([NH2+]C)(C(N)=O)C2)cc1,carboxyl
116043,Please add a nitro to the molecule O=C(NCc1ccncc1)[C@H]1c2ccccc2C(=O)N(Cc2ccccc2)C12CCCCC2.,O=C(NCc1ccncc1)[C@H]1c2ccccc2C(=O)N(Cc2ccccc2)C12CCCCC2,nitro
177590,Add a hydroxyl to the molecule Cc1ccc(-n2nc(C)c3c2OC(N)=C(C#N)[C@H]3c2ccccc2F)cc1.,Cc1ccc(-n2nc(C)c3c2OC(N)=C(C#N)[C@H]3c2ccccc2F)cc1,hydroxyl
107751,Please add a benzene ring to the molecule C[C@](NC(=O)CSCc1cccs1)(C(=O)[O-])C(F)(F)F.,C[C@](NC(=O)CSCc1cccs1)(C(=O)[O-])C(F)(F)F,benzene ring
45297,Please add a benzene ring to the molecule COc1ccc(-c2nc(C[NH+]3CCN(Cc4ccc(F)cc4)C(=O)C3)c(C)o2)cc1C.,COc1ccc(-c2nc(C[NH+]3CCN(Cc4ccc(F)cc4)C(=O)C3)c(C)o2)cc1C,benzene ring
149458,Modify the molecule COc1cc(NC(=O)c2ccccc2F)ccc1-c1ccc(CO)o1 by adding a benzene ring.,COc1cc(NC(=O)c2ccccc2F)ccc1-c1ccc(CO)o1,benzene ring
98789,Please add a amide to the molecule CCNC(=O)CNC(=O)NCc1ccc(NC(=O)c2ccco2)cc1.,CCNC(=O)CNC(=O)NCc1ccc(NC(=O)c2ccco2)cc1,amide
80367,Add a benzene ring to the molecule CC[C@H]1S/C(=N\N=C\c2ccco2)N(Cc2ccccc2C)C1=O.,CC[C@H]1S/C(=N\N=C\c2ccco2)N(Cc2ccccc2C)C1=O,benzene ring
133852,Modify the molecule COCCN(C(=O)c1ccccc1)c1nc(-c2ccc(OC)cc2)cs1 by adding a amine.,COCCN(C(=O)c1ccccc1)c1nc(-c2ccc(OC)cc2)cs1,amine
102136,Add a nitro to the molecule CC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1ccccc1OCc1ccc(Cl)cc1Cl.,CC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1ccccc1OCc1ccc(Cl)cc1Cl,nitro
34180,Modify the molecule CC(=O)Nc1ccccc1-c1nnc(SCC(=O)Nc2cccc3ccccc23)nc1[O-] by adding a amide.,CC(=O)Nc1ccccc1-c1nnc(SCC(=O)Nc2cccc3ccccc23)nc1[O-],amide
112158,Modify the molecule C[C@H]1C[C@@H](C)C[NH+](CCCNC(=O)NCc2ncn(C)n2)C1 by adding a amide.,C[C@H]1C[C@@H](C)C[NH+](CCCNC(=O)NCc2ncn(C)n2)C1,amide
233151,Add a aldehyde to the molecule Cc1nc(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cs1.,Cc1nc(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)cs1,aldehyde
47990,Modify the molecule CN1CCO[C@H](C[NH2+]Cc2cncn2C2CC2)C1 by adding a amine.,CN1CCO[C@H](C[NH2+]Cc2cncn2C2CC2)C1,amine
69638,Please add a hydroxyl to the molecule O=C(NCc1cc(F)cc(F)c1)c1cccnc1.,O=C(NCc1cc(F)cc(F)c1)c1cccnc1,hydroxyl
171957,Please add a hydroxyl to the molecule CCCn1ncc2ccc([C@@H]3CCCN(Cc4[nH]cc[nH+]4)C3)nc21.,CCCn1ncc2ccc([C@@H]3CCCN(Cc4[nH]cc[nH+]4)C3)nc21,hydroxyl
158332,Add a carboxyl to the molecule O=C(Cn1c(=O)oc2ccccc21)Nc1ccc(-c2nc3ccccc3o2)cc1.,O=C(Cn1c(=O)oc2ccccc21)Nc1ccc(-c2nc3ccccc3o2)cc1,carboxyl
121119,Add a hydroxyl to the molecule CCNC(=O)N1CC[C@@H]([NH2+][C@H](Cc2ccccc2)c2sccc2C)C1.,CCNC(=O)N1CC[C@@H]([NH2+][C@H](Cc2ccccc2)c2sccc2C)C1,hydroxyl
231615,Add a hydroxyl to the molecule CC[C@H](C)N(C)C(=O)Nc1ccc2c(c1)CCC2.,CC[C@H](C)N(C)C(=O)Nc1ccc2c(c1)CCC2,hydroxyl
43041,Please add a carboxyl to the molecule CCC[C@@H]1[C@H](C)CCCN1C(=O)c1ccc(Cl)cn1.,CCC[C@@H]1[C@H](C)CCCN1C(=O)c1ccc(Cl)cn1,carboxyl
215870,Add a nitrile to the molecule C[C@@H]1C[C@H](NC(=O)[C@@H]2C[C@@H]2C)CC(C)(C)C1.,C[C@@H]1C[C@H](NC(=O)[C@@H]2C[C@@H]2C)CC(C)(C)C1,nitrile
143775,Modify the molecule CC[C@H](NC(=O)N[C@H]1CCCC[C@@H]1OC)c1nc(C)cs1 by adding a aldehyde.,CC[C@H](NC(=O)N[C@H]1CCCC[C@@H]1OC)c1nc(C)cs1,aldehyde
92715,Modify the molecule CO[C@@H](c1ccccc1)c1nc2ccccc2[nH]c1=O by adding a benzene ring.,CO[C@@H](c1ccccc1)c1nc2ccccc2[nH]c1=O,benzene ring
90818,Please add a halo to the molecule N#Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1.,N#Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1,halo
49658,Add a benzene ring to the molecule Cn1cc[nH+]c1CN(CCO)C(=O)[C@@H]1CC2(CC[NH2+]CC2)CN1.,Cn1cc[nH+]c1CN(CCO)C(=O)[C@@H]1CC2(CC[NH2+]CC2)CN1,benzene ring
142623,Modify the molecule CC(C)c1ccc(CNc2ncc(Br)cn2)cc1 by adding a carboxyl.,CC(C)c1ccc(CNc2ncc(Br)cn2)cc1,carboxyl
38685,Please add a aldehyde to the molecule Cc1[nH]c(=O)sc1S(=O)(=O)N[C@@H]1CCCCC[C@@H]1C(=O)[O-].,Cc1[nH]c(=O)sc1S(=O)(=O)N[C@@H]1CCCCC[C@@H]1C(=O)[O-],aldehyde
41945,Add a carboxyl to the molecule Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccnc2)N2CCN(c3ccccc3F)CC2)cc1F.,Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccnc2)N2CCN(c3ccccc3F)CC2)cc1F,carboxyl
20697,Modify the molecule Cc1ccc(NC(=O)C2CCN(c3ncnc4onc(C)c34)CC2)c(C)c1 by adding a benzene ring.,Cc1ccc(NC(=O)C2CCN(c3ncnc4onc(C)c34)CC2)c(C)c1,benzene ring
169557,Add a amide to the molecule CN(CCn1cnnc1)S(=O)(=O)N1CCC(C(C)(C)C)CC1.,CN(CCn1cnnc1)S(=O)(=O)N1CCC(C(C)(C)C)CC1,amide
14114,Please add a halo to the molecule CCOC(=O)C1CCN(C(=O)C2(c3ccc(Cl)cc3)CCC2)CC1.,CCOC(=O)C1CCN(C(=O)C2(c3ccc(Cl)cc3)CCC2)CC1,halo
88263,Add a amide to the molecule CCN(CC)C(=O)c1ccc(NC(=O)[C@@H](C)n2cncn2)cc1Cl.,CCN(CC)C(=O)c1ccc(NC(=O)[C@@H](C)n2cncn2)cc1Cl,amide
47334,Modify the molecule CC(=O)N1CCN(C(=O)CCc2csc(NC(=O)c3ccc(=O)[nH]c3)n2)CC1 by adding a amine.,CC(=O)N1CCN(C(=O)CCc2csc(NC(=O)c3ccc(=O)[nH]c3)n2)CC1,amine
237830,Modify the molecule CCCCCN1C(=O)/C(=C\c2c(N3C[C@H](C)O[C@H](C)C3)nc3c(C)cccn3c2=O)SC1=S by adding a amide.,CCCCCN1C(=O)/C(=C\c2c(N3C[C@H](C)O[C@H](C)C3)nc3c(C)cccn3c2=O)SC1=S,amide
16744,Please add a carboxyl to the molecule Cc1cc(C)n(Cc2ccc(C(=O)N3CCC(=O)N(CCOc4ccccc4)CC3)cc2)n1.,Cc1cc(C)n(Cc2ccc(C(=O)N3CCC(=O)N(CCOc4ccccc4)CC3)cc2)n1,carboxyl
203129,Add a aldehyde to the molecule Cc1ccc(C)c(OC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1.,Cc1ccc(C)c(OC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)c1,aldehyde
112724,Add a halo to the molecule C[C@H]1CN(CCCCNC(=O)C(C)(C)c2ccccc2F)C[C@H](C)O1.,C[C@H]1CN(CCCCNC(=O)C(C)(C)c2ccccc2F)C[C@H](C)O1,halo
140155,Modify the molecule Cc1ccc(S(=O)(=O)C[C@@H](O)COc2ccc(F)cc2Cl)c(C)c1 by adding a amide.,Cc1ccc(S(=O)(=O)C[C@@H](O)COc2ccc(F)cc2Cl)c(C)c1,amide
25688,Modify the molecule C[C@H]1CN([C@]2(C[NH3+])CCCC2(C)C)CCO1 by adding a hydroxyl.,C[C@H]1CN([C@]2(C[NH3+])CCCC2(C)C)CCO1,hydroxyl
46014,Please add a hydroxyl to the molecule Cc1nnc(/N=C([O-])/C(Cc2ccccc2)=C2/SC(=S)N(Cc3ccccc3)C2=O)s1.,Cc1nnc(/N=C([O-])/C(Cc2ccccc2)=C2/SC(=S)N(Cc3ccccc3)C2=O)s1,hydroxyl
58358,Add a amide to the molecule O=C(CSc1nc2ncccn2n1)N1CCC[C@H]2CCCC[C@@H]21.,O=C(CSc1nc2ncccn2n1)N1CCC[C@H]2CCCC[C@@H]21,amide
69666,Add a amine to the molecule COc1ccccc1C[NH2+]CCc1ccccc1C.,COc1ccccc1C[NH2+]CCc1ccccc1C,amine
173311,Modify the molecule NC(=O)C1CCN(C(=O)/C=C/c2cn(-c3ccccc3)nc2-c2cccs2)CC1 by adding a amine.,NC(=O)C1CCN(C(=O)/C=C/c2cn(-c3ccccc3)nc2-c2cccs2)CC1,amine
225608,Modify the molecule O=S(=O)(NC1CC[NH+](Cc2ccc(Cl)cc2)CC1)c1cncc(F)c1 by adding a benzene ring.,O=S(=O)(NC1CC[NH+](Cc2ccc(Cl)cc2)CC1)c1cncc(F)c1,benzene ring
125058,Add a carboxyl to the molecule O=C1CC2(CCCC2)C(=O)N1CC(=O)N(c1ccccc1)[C@@H]1CCS(=O)(=O)C1.,O=C1CC2(CCCC2)C(=O)N1CC(=O)N(c1ccccc1)[C@@H]1CCS(=O)(=O)C1,carboxyl
222509,Modify the molecule C[C@H]1CCN(C(=O)Nc2cc(C(C)(C)C)nn2C(C)(C)C)C[C@@H]1O by adding a benzene ring.,C[C@H]1CCN(C(=O)Nc2cc(C(C)(C)C)nn2C(C)(C)C)C[C@@H]1O,benzene ring
61067,Add a amine to the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccc(OC)cc1.,CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1ccc(OC)cc1,amine
549,Modify the molecule CCOc1ccccc1/C=C1\Oc2c(ccc([O-])c2C[NH+]2CCN(C)CC2)C1=O by adding a benzene ring.,CCOc1ccccc1/C=C1\Oc2c(ccc([O-])c2C[NH+]2CCN(C)CC2)C1=O,benzene ring
188387,Add a benzene ring to the molecule NC(=O)[C@@H]1CCCCN1C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1.,NC(=O)[C@@H]1CCCCN1C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1,benzene ring
141687,Modify the molecule Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)NCCCc1ccc(Cl)cc1 by adding a benzene ring.,Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)NCCCc1ccc(Cl)cc1,benzene ring
212387,Add a hydroxyl to the molecule O=C(c1nc(Cl)ccc1Cl)N1CCN2C(=O)NC[C@H]2C1.,O=C(c1nc(Cl)ccc1Cl)N1CCN2C(=O)NC[C@H]2C1,hydroxyl
83836,Modify the molecule COc1ccc(N2C(=O)C[C@@H](Nc3ccc(S(=O)(=O)[N-]c4nccs4)cc3)C2=O)cc1Cl by adding a hydroxyl.,COc1ccc(N2C(=O)C[C@@H](Nc3ccc(S(=O)(=O)[N-]c4nccs4)cc3)C2=O)cc1Cl,hydroxyl
154150,Please add a benzene ring to the molecule Cc1cc(C)c(O)c(NC(=O)[C@@H](C)[NH3+])c1.,Cc1cc(C)c(O)c(NC(=O)[C@@H](C)[NH3+])c1,benzene ring
235291,Add a amide to the molecule O=C(N1CCCc2ccccc21)C1(c2ccc(F)cc2)CC1.,O=C(N1CCCc2ccccc21)C1(c2ccc(F)cc2)CC1,amide
162905,Add a amide to the molecule Cc1cc(C)cc(CS(=O)(=O)Cc2cccnc2C#N)c1.,Cc1cc(C)cc(CS(=O)(=O)Cc2cccnc2C#N)c1,amide
87413,Please add a hydroxyl to the molecule Cc1noc(COc2cccnc2F)n1.,Cc1noc(COc2cccnc2F)n1,hydroxyl
23147,Add a hydroxyl to the molecule CCC[C@]1(c2ccccc2)NC(=O)N(CC(=O)NC(C)(C)CC)C1=O.,CCC[C@]1(c2ccccc2)NC(=O)N(CC(=O)NC(C)(C)CC)C1=O,hydroxyl
111310,Please add a hydroxyl to the molecule COC(=O)c1cc(C)ccc1NC(=O)c1cccc(Nc2cnn(C)c2)c1.,COC(=O)c1cc(C)ccc1NC(=O)c1cccc(Nc2cnn(C)c2)c1,hydroxyl
226510,Please add a amine to the molecule O[C@H](COc1cc(Cl)ccc1Cl)CSc1nc(-c2ccncc2)n[nH]1.,O[C@H](COc1cc(Cl)ccc1Cl)CSc1nc(-c2ccncc2)n[nH]1,amine
42955,Please add a hydroxyl to the molecule COc1cccc(C(=O)Nc2cccc([S@](C)=O)c2)c1OC.,COc1cccc(C(=O)Nc2cccc([S@](C)=O)c2)c1OC,hydroxyl
20645,Add a halo to the molecule COCCCN(C(=O)[C@H]1CC=CCC1)[C@@H]1CCS(=O)(=O)C1.,COCCCN(C(=O)[C@H]1CC=CCC1)[C@@H]1CCS(=O)(=O)C1,halo
97155,Please add a halo to the molecule CO[C@@H](CNC(=O)N1CCC[C@@H](CN2CCOCC2)C1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)N1CCC[C@@H](CN2CCOCC2)C1)c1ccc(F)cc1,halo
97720,Modify the molecule O[C@H](Cc1cc(Cl)ccc1Cl)[C@@H]1C[NH+]2CCN1CC2 by adding a nitro.,O[C@H](Cc1cc(Cl)ccc1Cl)[C@@H]1C[NH+]2CCN1CC2,nitro
217391,Please add a amine to the molecule CCc1nn(C)c(OC)c1CNC(=O)N1CCC(CN2CCOCC2)CC1.,CCc1nn(C)c(OC)c1CNC(=O)N1CCC(CN2CCOCC2)CC1,amine
181346,Add a amide to the molecule COc1ccccc1[C@@H](CNC(=O)c1cc2ccccc2oc1=O)[NH+]1CCCC1.,COc1ccccc1[C@@H](CNC(=O)c1cc2ccccc2oc1=O)[NH+]1CCCC1,amide
34415,Please add a amide to the molecule O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1.,O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1,amide
99894,Modify the molecule O=C([O-])c1cc(-c2ccccc2)c2c(n1)CCCC2=O by adding a carboxyl.,O=C([O-])c1cc(-c2ccccc2)c2c(n1)CCCC2=O,carboxyl
6644,Modify the molecule C[C@@H](NC(=O)[C@@H](C)[NH+]1CCC(O)CC1)c1ccc2c(c1)CCCC2 by adding a benzene ring.,C[C@@H](NC(=O)[C@@H](C)[NH+]1CCC(O)CC1)c1ccc2c(c1)CCCC2,benzene ring
40424,Please add a amine to the molecule Cc1cc(C)cc(N2C(=O)[C@H]3[C@@H]4C=C[C@H]([C@H]3C2=O)C42CC2)c1.,Cc1cc(C)cc(N2C(=O)[C@H]3[C@@H]4C=C[C@H]([C@H]3C2=O)C42CC2)c1,amine
125128,Modify the molecule COc1ccccc1CCNC(=O)c1ccc(Cn2nnc3ccccc3c2=O)cc1 by adding a benzene ring.,COc1ccccc1CCNC(=O)c1ccc(Cn2nnc3ccccc3c2=O)cc1,benzene ring
134965,Modify the molecule Cc1nc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)sc1-c1ccccc1 by adding a hydroxyl.,Cc1nc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)sc1-c1ccccc1,hydroxyl
87007,Add a aldehyde to the molecule C[NH2+]CC(=O)N1CCC[C@H](CCc2c(F)cccc2F)C1.,C[NH2+]CC(=O)N1CCC[C@H](CCc2c(F)cccc2F)C1,aldehyde
24616,Add a hydroxyl to the molecule C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1ccccc1OC(F)(F)F.,C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1ccccc1OC(F)(F)F,hydroxyl
64064,Modify the molecule C[NH+]1CCCN(C(=O)c2cc3cc(Cl)ccc3oc2=O)CC1 by adding a amide.,C[NH+]1CCCN(C(=O)c2cc3cc(Cl)ccc3oc2=O)CC1,amide
120835,Add a hydroxyl to the molecule O=C([O-])[C@H]1CC(=O)N(CCS(=O)(=O)c2ccc(F)cc2)C1.,O=C([O-])[C@H]1CC(=O)N(CCS(=O)(=O)c2ccc(F)cc2)C1,hydroxyl
213880,Please add a nitro to the molecule CCN(CC)S(=O)(=O)c1ccc(F)c(C(=O)Nc2cc(C)ccc2F)c1.,CCN(CC)S(=O)(=O)c1ccc(F)c(C(=O)Nc2cc(C)ccc2F)c1,nitro
177385,Modify the molecule Cc1ccc(CC[C@H](O)[C@H](C)c2ccccn2)cc1 by adding a hydroxyl.,Cc1ccc(CC[C@H](O)[C@H](C)c2ccccn2)cc1,hydroxyl
171412,Modify the molecule COC(=O)c1ccc(CNC(=O)c2cnc(C)cn2)cc1 by adding a hydroxyl.,COC(=O)c1ccc(CNC(=O)c2cnc(C)cn2)cc1,hydroxyl
109969,Add a halo to the molecule CCCCCn1nc(C(=O)NC2(C#N)CCCCC2)c2ccccc2c1=O.,CCCCCn1nc(C(=O)NC2(C#N)CCCCC2)c2ccccc2c1=O,halo
2396,Please add a halo to the molecule Cc1ccc(/N=C2/COCCN2)cc1.,Cc1ccc(/N=C2/COCCN2)cc1,halo
130692,Add a halo to the molecule C=CCN(c1ccccc1Cl)S(=O)(=O)c1cccc(C(=O)N2CCO[C@H](C)C2)c1.,C=CCN(c1ccccc1Cl)S(=O)(=O)c1cccc(C(=O)N2CCO[C@H](C)C2)c1,halo
8901,Modify the molecule COC(=O)[C@@H]1C[C@H]1C(=O)NNc1cc(C#N)cc(Cl)n1 by adding a hydroxyl.,COC(=O)[C@@H]1C[C@H]1C(=O)NNc1cc(C#N)cc(Cl)n1,hydroxyl
38870,Add a amide to the molecule Cn1nccc1C(=O)Nc1nc2ccccc2n1CC[NH+]1CCOCC1.,Cn1nccc1C(=O)Nc1nc2ccccc2n1CC[NH+]1CCOCC1,amide
100708,Modify the molecule CCC[NH2+][C@H](C(OC)OC)[C@H]1CCOC2(CCOCC2)C1 by adding a nitro.,CCC[NH2+][C@H](C(OC)OC)[C@H]1CCOC2(CCOCC2)C1,nitro
34930,Please add a hydroxyl to the molecule O=C(NCCCn1cc[nH+]c1)N1CCc2ccc(O)cc2C1.,O=C(NCCCn1cc[nH+]c1)N1CCc2ccc(O)cc2C1,hydroxyl
37955,Add a hydroxyl to the molecule Cc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3)c2C)cc1[N+](=O)[O-].,Cc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3)c2C)cc1[N+](=O)[O-],hydroxyl
74079,Add a hydroxyl to the molecule COc1ccc(NC(=O)c2ccccc2OCc2noc(C)n2)c(OC)c1.,COc1ccc(NC(=O)c2ccccc2OCc2noc(C)n2)c(OC)c1,hydroxyl
79552,Add a amine to the molecule CCOC(=O)c1cccc(NC(=O)Cn2c3c(c(=O)n2-c2ccccc2)Cc2ccccc2O3)c1.,CCOC(=O)c1cccc(NC(=O)Cn2c3c(c(=O)n2-c2ccccc2)Cc2ccccc2O3)c1,amine
94508,Please add a amide to the molecule N#Cc1ccc(N(C(=O)c2cc3c(s2)CCOC3)C2CC2)cc1.,N#Cc1ccc(N(C(=O)c2cc3c(s2)CCOC3)C2CC2)cc1,amide
211173,Add a aldehyde to the molecule COc1ccc(S(=O)(=O)Nc2nc(C(=O)Nc3ccccc3OC)cs2)cc1.,COc1ccc(S(=O)(=O)Nc2nc(C(=O)Nc3ccccc3OC)cs2)cc1,aldehyde
49176,Please add a amide to the molecule C[C@@H]1Cc2cc(S(=O)(=O)NCc3ccco3)ccc2N1.,C[C@@H]1Cc2cc(S(=O)(=O)NCc3ccco3)ccc2N1,amide
42184,Please add a hydroxyl to the molecule CCOc1cc(Br)ccc1NC(=O)NNc1cnccn1.,CCOc1cc(Br)ccc1NC(=O)NNc1cnccn1,hydroxyl
188907,Please add a amide to the molecule Cc1cc(Nc2nc(C)cc(C)n2)cc([C@H]2CCC[NH+]2CC(=O)Nc2ccccc2F)n1.,Cc1cc(Nc2nc(C)cc(C)n2)cc([C@H]2CCC[NH+]2CC(=O)Nc2ccccc2F)n1,amide
223605,Please add a benzene ring to the molecule COc1ccccc1CNC(=O)[C@@]1(C)Cn2c(cc3ccccc32)C(=O)N1CCc1ccc(C)cc1.,COc1ccccc1CNC(=O)[C@@]1(C)Cn2c(cc3ccccc32)C(=O)N1CCc1ccc(C)cc1,benzene ring
168745,Add a carboxyl to the molecule CC(C)OC1CCC(NC(=O)Nc2cncc3ccccc23)CC1.,CC(C)OC1CCC(NC(=O)Nc2cncc3ccccc23)CC1,carboxyl
233395,Please add a hydroxyl to the molecule COc1cc(C(=O)N2CCN(S(C)(=O)=O)CC2)cc2occc12.,COc1cc(C(=O)N2CCN(S(C)(=O)=O)CC2)cc2occc12,hydroxyl
49094,Modify the molecule CCCn1cc(C(=O)N2CCC(O)(c3ccc(C)cn3)CC2)c(C)n1 by adding a amide.,CCCn1cc(C(=O)N2CCC(O)(c3ccc(C)cn3)CC2)c(C)n1,amide
228592,Please add a benzene ring to the molecule O=C(CC[C@H](O)c1ccccc1)N/N=C/c1ccccc1Cl.,O=C(CC[C@H](O)c1ccccc1)N/N=C/c1ccccc1Cl,benzene ring
90760,Please add a amide to the molecule Cc1ccc(NC(=O)N2CCC[C@H]2C(N)=O)cc1OC(F)F.,Cc1ccc(NC(=O)N2CCC[C@H]2C(N)=O)cc1OC(F)F,amide
107264,Add a halo to the molecule CCc1noc(CC)c1CNC(=O)Nc1cc(Br)ccc1C.,CCc1noc(CC)c1CNC(=O)Nc1cc(Br)ccc1C,halo
218951,Please add a nitro to the molecule CNC(=O)[C@H](C)NC(=O)c1sc2cccc(F)c2c1N.,CNC(=O)[C@H](C)NC(=O)c1sc2cccc(F)c2c1N,nitro
100151,Add a halo to the molecule O=C(Cn1ncn2nc(-c3ccccc3)cc2c1=O)NCC[NH+]1CCCCCC1.,O=C(Cn1ncn2nc(-c3ccccc3)cc2c1=O)NCC[NH+]1CCCCCC1,halo
121060,Please add a benzene ring to the molecule CCCNC(=O)CN1C(=O)N[C@@](C)(c2ccc(C(C)(C)C)cc2)C1=O.,CCCNC(=O)CN1C(=O)N[C@@](C)(c2ccc(C(C)(C)C)cc2)C1=O,benzene ring
65765,Add a benzene ring to the molecule C[C@H]([NH2+]CC1(CO)CCOCC1)c1cncc(F)c1.,C[C@H]([NH2+]CC1(CO)CCOCC1)c1cncc(F)c1,benzene ring
1621,Add a benzene ring to the molecule CNC(=O)[C@@H]1C[NH2+]CCN(C(C)=O)C1.,CNC(=O)[C@@H]1C[NH2+]CCN(C(C)=O)C1,benzene ring
183358,Add a amine to the molecule Clc1cccnc1NC1CC[NH+]([C@H]2CCOC2)CC1.,Clc1cccnc1NC1CC[NH+]([C@H]2CCOC2)CC1,amine
167242,Please add a carboxyl to the molecule O=C(c1ccccc1)N1N=C(c2ccccc2[N-]S(=O)(=O)c2ccccc2)C[C@H]1c1ccco1.,O=C(c1ccccc1)N1N=C(c2ccccc2[N-]S(=O)(=O)c2ccccc2)C[C@H]1c1ccco1,carboxyl
114846,Add a halo to the molecule Cc1cc(C)c(C(=O)N(CCC(F)(F)F)CC2CC2)o1.,Cc1cc(C)c(C(=O)N(CCC(F)(F)F)CC2CC2)o1,halo
45453,Modify the molecule CC(=O)Nc1ccc(Br)cc1NC(=O)Cc1csc2nc(-c3ccccc3)cn12 by adding a benzene ring.,CC(=O)Nc1ccc(Br)cc1NC(=O)Cc1csc2nc(-c3ccccc3)cn12,benzene ring
101001,Please add a aldehyde to the molecule C[C@H](c1ccc(-c2nc3c([nH]2)CC[NH2+]C3)cc1)N1CCOCC1.,C[C@H](c1ccc(-c2nc3c([nH]2)CC[NH2+]C3)cc1)N1CCOCC1,aldehyde
216318,Modify the molecule CCc1nn2c(c1-c1ccc(OC)c(OC)c1)NC(=O)[C@H]2CC(=O)Nc1cccc2ccccc12 by adding a amide.,CCc1nn2c(c1-c1ccc(OC)c(OC)c1)NC(=O)[C@H]2CC(=O)Nc1cccc2ccccc12,amide
71284,Add a amine to the molecule O=C(Cc1cccc(F)c1)Nc1nc2ccccc2s1.,O=C(Cc1cccc(F)c1)Nc1nc2ccccc2s1,amine
20548,Modify the molecule C[C@@H]1C[C@@H]1NC(=O)C(=O)Nc1ccc(OCC2CCCCC2)cc1 by adding a halo.,C[C@@H]1C[C@@H]1NC(=O)C(=O)Nc1ccc(OCC2CCCCC2)cc1,halo
166723,Please add a hydroxyl to the molecule CC(C)C[C@H](C[NH+](C)C)NCc1cccc(O)c1.,CC(C)C[C@H](C[NH+](C)C)NCc1cccc(O)c1,hydroxyl
219912,Please add a hydroxyl to the molecule CCCCC[NH+](C)CC(=O)Nc1ccc(C#N)cc1.,CCCCC[NH+](C)CC(=O)Nc1ccc(C#N)cc1,hydroxyl
224750,Modify the molecule CCS[C@H]1CC[C@@H]([NH+](C)CC(=O)Nc2c(C)cccc2CC)C1 by adding a hydroxyl.,CCS[C@H]1CC[C@@H]([NH+](C)CC(=O)Nc2c(C)cccc2CC)C1,hydroxyl
2624,Modify the molecule CCOc1ccccc1OC/C=C/C[NH+](C)C by adding a thiol.,CCOc1ccccc1OC/C=C/C[NH+](C)C,thiol
231499,Modify the molecule Cc1ccc(F)c([C@H](N)C(F)(F)F)c1Cl by adding a halo.,Cc1ccc(F)c([C@H](N)C(F)(F)F)c1Cl,halo
115941,Please add a benzene ring to the molecule CCC(=O)OCc1cn(C)nc1C(F)(F)F.,CCC(=O)OCc1cn(C)nc1C(F)(F)F,benzene ring
101966,Please add a aldehyde to the molecule CCc1nn(C)cc1CNC(=O)c1cc(-c2cc(C)sc2C)nc2c1cnn2C(C)C.,CCc1nn(C)cc1CNC(=O)c1cc(-c2cc(C)sc2C)nc2c1cnn2C(C)C,aldehyde
104700,Please add a amide to the molecule CS(=O)(=O)c1ccc(C(=O)Nc2n[nH]c3ccc([N+](=O)[O-])cc23)cc1.,CS(=O)(=O)c1ccc(C(=O)Nc2n[nH]c3ccc([N+](=O)[O-])cc23)cc1,amide
231975,Please add a amide to the molecule O=C(CN1CCN(c2ccc(O)cc2)CC1)Nc1nc2ccc(F)cc2s1.,O=C(CN1CCN(c2ccc(O)cc2)CC1)Nc1nc2ccc(F)cc2s1,amide
6741,Modify the molecule COc1ccc2[nH]/c(=N/C(=O)[C@@H]3CC(=O)C(OCc4ccccc4)=CO3)sc2c1 by adding a benzene ring.,COc1ccc2[nH]/c(=N/C(=O)[C@@H]3CC(=O)C(OCc4ccccc4)=CO3)sc2c1,benzene ring
36361,Add a benzene ring to the molecule C[C@@H](c1ccccc1)n1c(-c2nccn2CCO)nc2ccccc21.,C[C@@H](c1ccccc1)n1c(-c2nccn2CCO)nc2ccccc21,benzene ring
52502,Modify the molecule C[C@H](Sc1ccccc1)C(=O)NNC(=O)c1csc(N2CCOCC2)n1 by adding a benzene ring.,C[C@H](Sc1ccccc1)C(=O)NNC(=O)c1csc(N2CCOCC2)n1,benzene ring
96180,Please add a amide to the molecule Cc1nc2n(n1)CCC[C@H]2NC(=O)Nc1cncc2ccccc12.,Cc1nc2n(n1)CCC[C@H]2NC(=O)Nc1cncc2ccccc12,amide
235662,Please add a benzene ring to the molecule Cc1cccc(NC(=O)[C@@H]2CC(=O)N(CCC3=c4cc(Cl)ccc4=[NH+]C3)C2)c1C.,Cc1cccc(NC(=O)[C@@H]2CC(=O)N(CCC3=c4cc(Cl)ccc4=[NH+]C3)C2)c1C,benzene ring
49419,Modify the molecule Cc1cc(CCNC(=O)c2nc3ccccc3s2)on1 by adding a carboxyl.,Cc1cc(CCNC(=O)c2nc3ccccc3s2)on1,carboxyl
233224,Please add a amine to the molecule CC(=O)N1N=C(COc2ccc(Cl)cc2Cl)O[C@H]1c1ccccc1Cl.,CC(=O)N1N=C(COc2ccc(Cl)cc2Cl)O[C@H]1c1ccccc1Cl,amine
231131,Please add a halo to the molecule O=C(Cc1ccc2c(c1)OCO2)Nc1nc(-c2ccc(Cl)s2)cs1.,O=C(Cc1ccc2c(c1)OCO2)Nc1nc(-c2ccc(Cl)s2)cs1,halo
60295,Please add a amide to the molecule CC[C@](C)([NH3+])C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)[O-].,CC[C@](C)([NH3+])C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)[O-],amide
106760,Add a halo to the molecule Cc1ccc(C)c(C[NH+](CCC(N)=O)Cc2ccccc2)c1.,Cc1ccc(C)c(C[NH+](CCC(N)=O)Cc2ccccc2)c1,halo
28775,Please add a hydroxyl to the molecule O=C(NCCc1cccs1)Nc1cccc(-c2nnc3n2CCC3)c1.,O=C(NCCc1cccs1)Nc1cccc(-c2nnc3n2CCC3)c1,hydroxyl
65766,Modify the molecule O=C(NCc1ccccc1Cl)[C@@H]1CCCN1C(=O)C1CC1 by adding a amide.,O=C(NCc1ccccc1Cl)[C@@H]1CCCN1C(=O)C1CC1,amide
169476,Add a carboxyl to the molecule O=C(Nc1ccccc1Cl)N1CCN(c2ccc(O)cc2)CC1.,O=C(Nc1ccccc1Cl)N1CCN(c2ccc(O)cc2)CC1,carboxyl
354,Modify the molecule Cc1cc(S(=O)(=O)N2CCN(C(=O)[C@H]3C[C@H]3c3ccc(Cl)cc3)CC2)c(C)s1 by adding a amide.,Cc1cc(S(=O)(=O)N2CCN(C(=O)[C@H]3C[C@H]3c3ccc(Cl)cc3)CC2)c(C)s1,amide
13802,Modify the molecule Cc1ccc(-c2n[nH]cc2CN2CC[C@H](S(=O)(=O)NC3CC3)C2)cc1 by adding a aldehyde.,Cc1ccc(-c2n[nH]cc2CN2CC[C@H](S(=O)(=O)NC3CC3)C2)cc1,aldehyde
145691,Please add a nitro to the molecule CC[C@@H](NC(=O)Nc1cc(OC)c(OC)cc1F)c1cc(F)ccc1F.,CC[C@@H](NC(=O)Nc1cc(OC)c(OC)cc1F)c1cc(F)ccc1F,nitro
78796,Please add a carboxyl to the molecule CC(C)C[NH+]1CCN(C(=O)N[C@H](C)c2ccc3c(c2)OCO3)CC1.,CC(C)C[NH+]1CCN(C(=O)N[C@H](C)c2ccc3c(c2)OCO3)CC1,carboxyl
66656,Add a hydroxyl to the molecule CCC(=O)c1ccc(OC(=O)Cn2nnc(-c3ccccc3)n2)cc1.,CCC(=O)c1ccc(OC(=O)Cn2nnc(-c3ccccc3)n2)cc1,hydroxyl
22714,Modify the molecule Cc1nnc(S[C@@H](C)C(=O)Nc2ccccc2Sc2ccccc2)n1N by adding a amine.,Cc1nnc(S[C@@H](C)C(=O)Nc2ccccc2Sc2ccccc2)n1N,amine
126749,Add a benzene ring to the molecule O=[N+]([O-])c1cccc([C@@H](O)C[NH2+]CCc2c[nH]c3ccccc23)c1.,O=[N+]([O-])c1cccc([C@@H](O)C[NH2+]CCc2c[nH]c3ccccc23)c1,benzene ring
121654,Modify the molecule O=S(=O)(/N=C(\[O-])[C@H]1CCCC[C@@H]1C(F)(F)F)c1cc(F)ccc1F by adding a halo.,O=S(=O)(/N=C(\[O-])[C@H]1CCCC[C@@H]1C(F)(F)F)c1cc(F)ccc1F,halo
243539,Modify the molecule C[C@@H]1CN(C[C@@H]2CCC[NH+]2Cc2ccc(-n3cncn3)cc2)C[C@@H](C)O1 by adding a hydroxyl.,C[C@@H]1CN(C[C@@H]2CCC[NH+]2Cc2ccc(-n3cncn3)cc2)C[C@@H](C)O1,hydroxyl
88330,Add a hydroxyl to the molecule Cc1cc2occ(CC(=O)NNC(=O)C[C@H]3CCS(=O)(=O)C3)c2cc1C(C)C.,Cc1cc2occ(CC(=O)NNC(=O)C[C@H]3CCS(=O)(=O)C3)c2cc1C(C)C,hydroxyl
170978,Add a thiol to the molecule Cc1cccc(S(=O)(=O)Nc2ccccc2N2CCCN(Cc3ccc(F)cc3)C2=O)c1.,Cc1cccc(S(=O)(=O)Nc2ccccc2N2CCCN(Cc3ccc(F)cc3)C2=O)c1,thiol
40685,Add a benzene ring to the molecule O[C@H](Cn1nnc2cc(Cl)c(Cl)cc21)c1ccccc1.,O[C@H](Cn1nnc2cc(Cl)c(Cl)cc21)c1ccccc1,benzene ring
5607,Modify the molecule CC[C@@H]1CCCC[NH+]1CC(=O)Nc1cccc(C(=O)NC2CC2)c1 by adding a nitro.,CC[C@@H]1CCCC[NH+]1CC(=O)Nc1cccc(C(=O)NC2CC2)c1,nitro
117843,Modify the molecule COc1cc(Cl)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1Cl by adding a benzene ring.,COc1cc(Cl)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1Cl,benzene ring
239747,Modify the molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1 by adding a amine.,Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1,amine
96975,Please add a amide to the molecule CCOc1cc(/C=N/N2C(=S)N=N[C@H]2[C@H]2C=C(c3ccccc3)N=N2)ccc1O.,CCOc1cc(/C=N/N2C(=S)N=N[C@H]2[C@H]2C=C(c3ccccc3)N=N2)ccc1O,amide
43872,Modify the molecule COc1cccc(CN(C)C(=O)C[C@](O)(c2nccn2C)C(F)(F)F)c1 by adding a carboxyl.,COc1cccc(CN(C)C(=O)C[C@](O)(c2nccn2C)C(F)(F)F)c1,carboxyl
191221,Modify the molecule C=CCNC(=O)NC(=O)[C@@H](C)N1CCO[C@H](c2ccc(F)cc2)C1 by adding a amide.,C=CCNC(=O)NC(=O)[C@@H](C)N1CCO[C@H](c2ccc(F)cc2)C1,amide
60513,Please add a amide to the molecule N#Cc1cccnc1NCCNC(=O)C[NH+]1CCc2sccc2C1.,N#Cc1cccnc1NCCNC(=O)C[NH+]1CCc2sccc2C1,amide
138585,Modify the molecule CC[C@@H](C)NC(=O)CCCN1C(=O)c2cccnc2Oc2ccccc21 by adding a amide.,CC[C@@H](C)NC(=O)CCCN1C(=O)c2cccnc2Oc2ccccc21,amide
84780,Add a aldehyde to the molecule CCn1ccnc(NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1=O.,CCn1ccnc(NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1=O,aldehyde
82402,Please add a hydroxyl to the molecule O=C(NC(C1CC1)C1CC1)C1(c2ccc(Br)cc2)CC1.,O=C(NC(C1CC1)C1CC1)C1(c2ccc(Br)cc2)CC1,hydroxyl
218864,Please add a benzene ring to the molecule C[C@](Cl)(c1ccccc1)C1OCCO1.,C[C@](Cl)(c1ccccc1)C1OCCO1,benzene ring
244956,Add a benzene ring to the molecule CC[C@@H]1CCC[C@@H](NC(=O)CNC(=O)C(C)(C)C)C1.,CC[C@@H]1CCC[C@@H](NC(=O)CNC(=O)C(C)(C)C)C1,benzene ring
26659,Modify the molecule CCCC(=O)N1CCCC[C@H]1C(=O)N[C@H](C)c1cccc(N2CCCC2)c1 by adding a hydroxyl.,CCCC(=O)N1CCCC[C@H]1C(=O)N[C@H](C)c1cccc(N2CCCC2)c1,hydroxyl
162346,Add a benzene ring to the molecule Cc1ccc([C@@H](C)N[C@H](C)c2c(F)cccc2F)cc1[N+](=O)[O-].,Cc1ccc([C@@H](C)N[C@H](C)c2c(F)cccc2F)cc1[N+](=O)[O-],benzene ring
222032,Modify the molecule COc1ccccc1-c1noc(COc2ccc(C=O)cc2Cl)n1 by adding a amide.,COc1ccccc1-c1noc(COc2ccc(C=O)cc2Cl)n1,amide
39160,Modify the molecule CC(C)[NH+]1CCCN(C(=O)c2cc(C3CC3)n(C(C)(C)C)n2)CC1 by adding a carboxyl.,CC(C)[NH+]1CCCN(C(=O)c2cc(C3CC3)n(C(C)(C)C)n2)CC1,carboxyl
200936,Please add a halo to the molecule C[C@H]1C[C@@H](C)CN(S(=O)(=O)c2cccc(C(=O)NCc3ccc(N4CCCC4)nc3)c2)C1.,C[C@H]1C[C@@H](C)CN(S(=O)(=O)c2cccc(C(=O)NCc3ccc(N4CCCC4)nc3)c2)C1,halo
52116,Please add a benzene ring to the molecule CCOc1ccc(C2=C[C@H](C(=O)N/N=C/c3cc(Br)ccc3O)N=N2)cc1OC.,CCOc1ccc(C2=C[C@H](C(=O)N/N=C/c3cc(Br)ccc3O)N=N2)cc1OC,benzene ring
143646,Add a hydroxyl to the molecule Cc1cccc([C@H]([NH2+]C2CCCCC2)c2ccccn2)c1.,Cc1cccc([C@H]([NH2+]C2CCCCC2)c2ccccn2)c1,hydroxyl
236533,Please add a benzene ring to the molecule Cc1cc(NC(=O)[C@H]2CCc3nc(N4CCOCC4)ncc3C2)ccc1F.,Cc1cc(NC(=O)[C@H]2CCc3nc(N4CCOCC4)ncc3C2)ccc1F,benzene ring
75748,Add a benzene ring to the molecule Cc1cc(N2CC[C@H](N[C@H]3CC(C)(C)Oc4cc(F)ccc43)C2=O)n(C)n1.,Cc1cc(N2CC[C@H](N[C@H]3CC(C)(C)Oc4cc(F)ccc43)C2=O)n(C)n1,benzene ring
239031,Modify the molecule COc1ccc(OC)c(NC(=O)N2CCc3[nH]c4ccc(Cl)cc4c3C2)c1 by adding a amide.,COc1ccc(OC)c(NC(=O)N2CCc3[nH]c4ccc(Cl)cc4c3C2)c1,amide
31953,Add a halo to the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)NCc2cccc(-c3ccc(C#N)s3)c2)C1.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)NCc2cccc(-c3ccc(C#N)s3)c2)C1,halo
95375,Add a benzene ring to the molecule CC(=O)Nc1ccc(F)c(NC(=O)[C@@H]2C[C@@H]2C)c1.,CC(=O)Nc1ccc(F)c(NC(=O)[C@@H]2C[C@@H]2C)c1,benzene ring
52173,Please add a hydroxyl to the molecule COC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)c(Cl)c2)ccn1.,COC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)c(Cl)c2)ccn1,hydroxyl
25888,Please add a benzene ring to the molecule Cc1c(C(=O)NCC[NH+]2CCCC[C@H]2C)nnn1-c1cccc2cccnc12.,Cc1c(C(=O)NCC[NH+]2CCCC[C@H]2C)nnn1-c1cccc2cccnc12,benzene ring
73684,Please add a aldehyde to the molecule Cc1ccc2c(c1)cc1c(=O)n(CC(=O)NCc3ccccn3)nc(C)n12.,Cc1ccc2c(c1)cc1c(=O)n(CC(=O)NCc3ccccn3)nc(C)n12,aldehyde
43090,Add a aldehyde to the molecule C[C@H]1OCC[C@@H]1C(=O)NC[C@H](O)c1c(F)cccc1F.,C[C@H]1OCC[C@@H]1C(=O)NC[C@H](O)c1c(F)cccc1F,aldehyde
233483,Add a benzene ring to the molecule Cc1ccc(NC(=O)c2cc(-c3cccnc3)on2)cc1C.,Cc1ccc(NC(=O)c2cc(-c3cccnc3)on2)cc1C,benzene ring
104303,Please add a amide to the molecule C[C@@H]1CCCCC[C@H]1Nc1ccc([N+](=O)[O-])c(N)n1.,C[C@@H]1CCCCC[C@H]1Nc1ccc([N+](=O)[O-])c(N)n1,amide
107169,Please add a benzene ring to the molecule N#CC1(CSc2nnc(-c3ccncc3)o2)CC1.,N#CC1(CSc2nnc(-c3ccncc3)o2)CC1,benzene ring
21733,Please add a halo to the molecule Cc1nc([C@H]2CN(C(=O)[C@@H]3C[C@@H]3c3ccc(F)cc3)CCO2)no1.,Cc1nc([C@H]2CN(C(=O)[C@@H]3C[C@@H]3c3ccc(F)cc3)CCO2)no1,halo
15424,Please add a aldehyde to the molecule CCNC(=O)[C@@H](C)Sc1ccc(NC(C)=O)cc1.,CCNC(=O)[C@@H](C)Sc1ccc(NC(C)=O)cc1,aldehyde
44880,Please add a nitro to the molecule CCC(CC)(NC(=O)NC[C@@H]1CCCOC1)C(=O)[O-].,CCC(CC)(NC(=O)NC[C@@H]1CCCOC1)C(=O)[O-],nitro
54795,Please add a amine to the molecule NS(=O)(=O)c1ccc(NC(=O)CCC(=O)N2CCOCC2)cc1.,NS(=O)(=O)c1ccc(NC(=O)CCC(=O)N2CCOCC2)cc1,amine
22133,Add a benzene ring to the molecule CCOc1ccc(C(=O)N2CCC[NH+]([C@H]3CCN(CC4CC4)C3=O)CC2)cc1.,CCOc1ccc(C(=O)N2CCC[NH+]([C@H]3CCN(CC4CC4)C3=O)CC2)cc1,benzene ring
179263,Please add a amine to the molecule CCN(Cc1ccccc1)C(=O)/C=C/c1ccc([N+](=O)[O-])cc1.,CCN(Cc1ccccc1)C(=O)/C=C/c1ccc([N+](=O)[O-])cc1,amine
43178,Please add a benzene ring to the molecule C[C@@H]1Oc2ccccc2N(CC(=O)NCc2cc3ccccc3[nH]2)C1=O.,C[C@@H]1Oc2ccccc2N(CC(=O)NCc2cc3ccccc3[nH]2)C1=O,benzene ring
78997,Add a hydroxyl to the molecule CC(=O)N1c2ncnn2[C@H](c2ccc(Cl)cc2)C[C@H]1c1ccc(Cl)cc1.,CC(=O)N1c2ncnn2[C@H](c2ccc(Cl)cc2)C[C@H]1c1ccc(Cl)cc1,hydroxyl
77631,Modify the molecule O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2c[nH]c3ncccc23)CC1 by adding a amide.,O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2c[nH]c3ncccc23)CC1,amide
158547,Add a benzene ring to the molecule Cc1cccc(CN2CCc3nnc([C@H](C)NC(=O)C4CC4)n3CC2)n1.,Cc1cccc(CN2CCc3nnc([C@H](C)NC(=O)C4CC4)n3CC2)n1,benzene ring
146244,Please add a carboxyl to the molecule CCOCCN(C)C(=O)c1ccc(Cl)cc1F.,CCOCCN(C)C(=O)c1ccc(Cl)cc1F,carboxyl
235819,Please add a hydroxyl to the molecule Cc1c(F)cc(N)cc1S(=O)(=O)N1CCOC[C@H]1C.,Cc1c(F)cc(N)cc1S(=O)(=O)N1CCOC[C@H]1C,hydroxyl
138038,Add a amine to the molecule Cc1ccc(-n2nnnc2N[C@H]2CC[NH+]3CCC[C@@H]3C2)cc1.,Cc1ccc(-n2nnnc2N[C@H]2CC[NH+]3CCC[C@@H]3C2)cc1,amine
134818,Please add a benzene ring to the molecule Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1.,Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1,benzene ring
156952,Please add a benzene ring to the molecule C[C@H](C(=O)Nc1ccc(N2CCCCC2)cc1C(N)=O)[NH+]1CCSCC1.,C[C@H](C(=O)Nc1ccc(N2CCCCC2)cc1C(N)=O)[NH+]1CCSCC1,benzene ring
38145,Please add a amine to the molecule COC(=O)Cc1n[n-]c(NC(=O)c2nc(C3CC3)n3ccccc23)n1.,COC(=O)Cc1n[n-]c(NC(=O)c2nc(C3CC3)n3ccccc23)n1,amine
114373,Add a amide to the molecule O=C(NNc1nc(-c2ccccc2)no1)c1cnn(-c2ccccc2)c1.,O=C(NNc1nc(-c2ccccc2)no1)c1cnn(-c2ccccc2)c1,amide
153404,Please add a benzene ring to the molecule CC(C)N1C(=O)C[C@@H](NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)C1=O.,CC(C)N1C(=O)C[C@@H](NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)C1=O,benzene ring
10680,Please add a halo to the molecule CC1(C)C[C@@H]1[NH2+]Cc1ccc(C(=O)[O-])cn1.,CC1(C)C[C@@H]1[NH2+]Cc1ccc(C(=O)[O-])cn1,halo
206907,Add a benzene ring to the molecule C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1.,C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1,benzene ring
164221,Please add a amide to the molecule CC(=O)c1ccc(NC(=O)N[C@H](C)c2nc3ccccc3[nH]2)cc1C.,CC(=O)c1ccc(NC(=O)N[C@H](C)c2nc3ccccc3[nH]2)cc1C,amide
9705,Modify the molecule Cc1ccc(OCC(=O)O[C@H](C)[C@H]2CCOC2)c(C)c1 by adding a benzene ring.,Cc1ccc(OCC(=O)O[C@H](C)[C@H]2CCOC2)c(C)c1,benzene ring
43466,Please add a benzene ring to the molecule CSC[C@@H](CCO)NC(=O)Nc1c(C)cc(Br)cc1C.,CSC[C@@H](CCO)NC(=O)Nc1c(C)cc(Br)cc1C,benzene ring
209809,Please add a benzene ring to the molecule CCOC(=O)N1CCC(C(=O)Nc2ccc(F)cc2)CC1.,CCOC(=O)N1CCC(C(=O)Nc2ccc(F)cc2)CC1,benzene ring
27159,Add a amide to the molecule CS(=O)(=O)NCCNC(=O)c1ccccc1I.,CS(=O)(=O)NCCNC(=O)c1ccccc1I,amide
184080,Modify the molecule Cc1ccc(-c2ccc(C(=O)NC(=S)Nc3ccc(S(N)(=O)=O)cc3)o2)cc1Cl by adding a nitro.,Cc1ccc(-c2ccc(C(=O)NC(=S)Nc3ccc(S(N)(=O)=O)cc3)o2)cc1Cl,nitro
124946,Modify the molecule C[C@H]1[C@H](C)S(=O)(=O)CCN1C(=O)c1ccnc(OC(C)(C)C)c1 by adding a amide.,C[C@H]1[C@H](C)S(=O)(=O)CCN1C(=O)c1ccnc(OC(C)(C)C)c1,amide
204604,Please add a amide to the molecule N#Cc1ccc(S(=O)(=O)N2CCC[C@@H]2c2ccncc2)cc1Cl.,N#Cc1ccc(S(=O)(=O)N2CCC[C@@H]2c2ccncc2)cc1Cl,amide
225483,Modify the molecule C#C[C@@H](NC)C1([NH+]2CCCC2)CCCC1 by adding a benzene ring.,C#C[C@@H](NC)C1([NH+]2CCCC2)CCCC1,benzene ring
96827,Modify the molecule CN(Cc1cccs1)C(=O)c1nc(-c2cccs2)n(-c2cccc(F)c2)n1 by adding a carboxyl.,CN(Cc1cccs1)C(=O)c1nc(-c2cccs2)n(-c2cccc(F)c2)n1,carboxyl
248671,Please add a hydroxyl to the molecule Cn1ncc2c(=O)n(Cc3ccc(NN)nc3)nnc21.,Cn1ncc2c(=O)n(Cc3ccc(NN)nc3)nnc21,hydroxyl
11591,Please add a amide to the molecule Cc1nc(-c2ccc(NC(=O)Nc3ccc4nsnc4c3)cc2)cs1.,Cc1nc(-c2ccc(NC(=O)Nc3ccc4nsnc4c3)cc2)cs1,amide
122373,Add a carboxyl to the molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(Br)o1.,Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(Br)o1,carboxyl
148974,Please add a aldehyde to the molecule Cc1cc(N2C(=O)C([O-])=C(C(=O)c3ccc(C)o3)[C@H]2c2ccc(C(C)(C)C)cc2)no1.,Cc1cc(N2C(=O)C([O-])=C(C(=O)c3ccc(C)o3)[C@H]2c2ccc(C(C)(C)C)cc2)no1,aldehyde
156396,Modify the molecule COc1cc(/C=C(\C#N)c2nc(-c3ccc(C)cc3)cs2)cc([N+](=O)[O-])c1[O-] by adding a amide.,COc1cc(/C=C(\C#N)c2nc(-c3ccc(C)cc3)cs2)cc([N+](=O)[O-])c1[O-],amide
54085,Please add a hydroxyl to the molecule CCC[C@H](NC(=O)c1ccc(O)c(Cl)c1)C(=O)N1CCc2sccc2C1.,CCC[C@H](NC(=O)c1ccc(O)c(Cl)c1)C(=O)N1CCc2sccc2C1,hydroxyl
54564,Please add a carboxyl to the molecule Cc1csc([C@@H](C)NC(=O)N2CCC[NH+](CCCc3ccccc3)CC2)n1.,Cc1csc([C@@H](C)NC(=O)N2CCC[NH+](CCCc3ccccc3)CC2)n1,carboxyl
35357,Add a benzene ring to the molecule CC1=C2C(=O)CCCC2=N[C@@H]1C(=O)N(C)Cc1ccc(OC(F)F)cc1.,CC1=C2C(=O)CCCC2=N[C@@H]1C(=O)N(C)Cc1ccc(OC(F)F)cc1,benzene ring
249315,Add a nitrile to the molecule CCCSC[C@H](O)[C@H](C)CC.,CCCSC[C@H](O)[C@H](C)CC,nitrile
163492,Add a hydroxyl to the molecule CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O.,CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O,hydroxyl
54157,Modify the molecule CC(=O)Nc1cccc([C@H](C)[NH2+]Cc2ccnn2C)c1 by adding a aldehyde.,CC(=O)Nc1cccc([C@H](C)[NH2+]Cc2ccnn2C)c1,aldehyde
153379,Add a amine to the molecule COc1cccc(S(=O)(=O)[C@@H](C)C(=O)NCC(C)C)c1.,COc1cccc(S(=O)(=O)[C@@H](C)C(=O)NCC(C)C)c1,amine
98586,Please add a benzene ring to the molecule Cc1nc(CN2C[C@H]3C[NH2+]C[C@@H]3C2)no1.,Cc1nc(CN2C[C@H]3C[NH2+]C[C@@H]3C2)no1,benzene ring
201211,Please add a benzene ring to the molecule CN(CC(N)=O)C(=O)C[C@@H]1COc2ccc(C(=O)N3CCOCC3)cc2N1C.,CN(CC(N)=O)C(=O)C[C@@H]1COc2ccc(C(=O)N3CCOCC3)cc2N1C,benzene ring
86711,Modify the molecule C[C@H](Cn1cccn1)OC(=O)c1scnc1C1CC1 by adding a amide.,C[C@H](Cn1cccn1)OC(=O)c1scnc1C1CC1,amide
10592,Please add a aldehyde to the molecule CC(=O)N(c1nccs1)C1CCCCC1.,CC(=O)N(c1nccs1)C1CCCCC1,aldehyde
139281,Please add a amide to the molecule CCCCC(=O)NNC(=O)c1cccc(S(C)(=O)=O)c1.,CCCCC(=O)NNC(=O)c1cccc(S(C)(=O)=O)c1,amide
17034,Modify the molecule Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1 by adding a benzene ring.,Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1,benzene ring
95875,Modify the molecule Cc1ccc(C)c(N2C(=O)[C@H]3[C@H]4C=C[C@H](C4)[C@H]3C2=O)c1 by adding a hydroxyl.,Cc1ccc(C)c(N2C(=O)[C@H]3[C@H]4C=C[C@H](C4)[C@H]3C2=O)c1,hydroxyl
22090,Add a hydroxyl to the molecule CCC[C@@H](C(=O)N1CCc2c(nc(-c3cccnc3)[nH]c2=O)C1)n1cccc1.,CCC[C@@H](C(=O)N1CCc2c(nc(-c3cccnc3)[nH]c2=O)C1)n1cccc1,hydroxyl
13098,Modify the molecule O=C1/C(=C\c2cc3ccccc3o2)SC(=S)N1c1ccc(F)cc1 by adding a amine.,O=C1/C(=C\c2cc3ccccc3o2)SC(=S)N1c1ccc(F)cc1,amine
80523,Add a benzene ring to the molecule C[C@H]1SCCC[C@H]1[NH2+]Cc1ccc(N(C)C)cc1.,C[C@H]1SCCC[C@H]1[NH2+]Cc1ccc(N(C)C)cc1,benzene ring
54535,Add a benzene ring to the molecule CC(=O)N1CC[C@]2(O)CCN(C(=O)Cc3cc(C)ccc3C)C[C@@H]2C1.,CC(=O)N1CC[C@]2(O)CCN(C(=O)Cc3cc(C)ccc3C)C[C@@H]2C1,benzene ring
123728,Please add a benzene ring to the molecule C[NH+](C)[C@@H](CNC(=O)NNC(=O)c1cccc2ccccc12)c1ccco1.,C[NH+](C)[C@@H](CNC(=O)NNC(=O)c1cccc2ccccc12)c1ccco1,benzene ring
155120,Please add a aldehyde to the molecule C[C@H](c1ccccc1F)N(C)C(=O)CC[C@@H]1CCCO1.,C[C@H](c1ccccc1F)N(C)C(=O)CC[C@@H]1CCCO1,aldehyde
43471,Please add a benzene ring to the molecule CCCN1CC(=O)N2[C@@H](CC3=c4ccccc4=[NH+][C@H]3[C@@H]2c2ccccc2C)C1=O.,CCCN1CC(=O)N2[C@@H](CC3=c4ccccc4=[NH+][C@H]3[C@@H]2c2ccccc2C)C1=O,benzene ring
186626,Add a amide to the molecule CC(C)NC(=O)CNS(=O)(=O)c1ccc(C(C)(C)C)cc1.,CC(C)NC(=O)CNS(=O)(=O)c1ccc(C(C)(C)C)cc1,amide
76328,Modify the molecule O=C1C[C@@H](C(=O)N2CCCCC2)[C@@H](c2ccc3c(c2)OCCO3)O1 by adding a carboxyl.,O=C1C[C@@H](C(=O)N2CCCCC2)[C@@H](c2ccc3c(c2)OCCO3)O1,carboxyl
56129,Add a benzene ring to the molecule CC(=O)Nc1c(C)cc(N[C@H]2C[NH+](Cc3ccccc3)C(C)(C)C2)cc1C.,CC(=O)Nc1c(C)cc(N[C@H]2C[NH+](Cc3ccccc3)C(C)(C)C2)cc1C,benzene ring
203227,Please add a halo to the molecule CS(=O)(=O)CCC(=O)N[C@@H](c1ccccc1)c1ccc2nc[nH]c2c1.,CS(=O)(=O)CCC(=O)N[C@@H](c1ccccc1)c1ccc2nc[nH]c2c1,halo
32294,Modify the molecule Cn1cc(C(=O)NCc2ccc(-c3nc4ccccc4s3)o2)cn1 by adding a amine.,Cn1cc(C(=O)NCc2ccc(-c3nc4ccccc4s3)o2)cn1,amine
94748,Please add a hydroxyl to the molecule COc1ccc(N2CCCN(C(=O)[C@@H](C)n3ccnc3)CC2)cc1.,COc1ccc(N2CCCN(C(=O)[C@@H](C)n3ccnc3)CC2)cc1,hydroxyl
78249,Please add a amide to the molecule COc1ccc(F)cc1C(=O)C1=C([O-])C(=O)N(CC[NH+]2CCCC2)[C@H]1c1ccncc1.,COc1ccc(F)cc1C(=O)C1=C([O-])C(=O)N(CC[NH+]2CCCC2)[C@H]1c1ccncc1,amide
185527,Please add a hydroxyl to the molecule C=CCO[C@H](C)C(=O)Oc1cccc(-n2cccn2)c1.,C=CCO[C@H](C)C(=O)Oc1cccc(-n2cccn2)c1,hydroxyl
148976,Add a benzene ring to the molecule CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2.,CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2,benzene ring
22669,Modify the molecule C[C@@H](c1nc(C(C)(C)C)no1)[NH+]1CCC(OCc2ccccc2F)CC1 by adding a aldehyde.,C[C@@H](c1nc(C(C)(C)C)no1)[NH+]1CCC(OCc2ccccc2F)CC1,aldehyde
120870,Add a benzene ring to the molecule CC[NH+]1CCN(c2ncnc(NNC(=O)c3ccccc3C)c2N)CC1.,CC[NH+]1CCN(c2ncnc(NNC(=O)c3ccccc3C)c2N)CC1,benzene ring
226960,Modify the molecule CCOc1ccc(Br)cc1S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)OCC#N by adding a aldehyde.,CCOc1ccc(Br)cc1S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)OCC#N,aldehyde
39302,Modify the molecule C/C(=C/C(=O)Nc1cn(C)nc1-c1ccccc1)c1ccc(F)cc1 by adding a hydroxyl.,C/C(=C/C(=O)Nc1cn(C)nc1-c1ccccc1)c1ccc(F)cc1,hydroxyl
248098,Add a amide to the molecule Cc1ccccc1[C@@H](Cc1ncnn1C(C)C)C(=O)[O-].,Cc1ccccc1[C@@H](Cc1ncnn1C(C)C)C(=O)[O-],amide
115493,Modify the molecule COc1ccc(C(=O)NCC(N)=S)cc1O by adding a hydroxyl.,COc1ccc(C(=O)NCC(N)=S)cc1O,hydroxyl
108390,Please add a benzene ring to the molecule COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1.,COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1,benzene ring
51702,Add a benzene ring to the molecule Cc1cc(C)cc(NC(=O)Cn2c(=O)n(CCc3ccccc3)c(=O)c3ncccc32)c1.,Cc1cc(C)cc(NC(=O)Cn2c(=O)n(CCc3ccccc3)c(=O)c3ncccc32)c1,benzene ring
11354,Please add a benzene ring to the molecule C[C@](O)(CCC[C@H]1CCCO1)c1cc(F)cc(F)c1.,C[C@](O)(CCC[C@H]1CCCO1)c1cc(F)cc(F)c1,benzene ring
152899,Modify the molecule Cn1nccc1C(=O)NC1CC[NH+](CC2(c3ccc(Cl)cc3)CCC2)CC1 by adding a benzene ring.,Cn1nccc1C(=O)NC1CC[NH+](CC2(c3ccc(Cl)cc3)CCC2)CC1,benzene ring
130796,Please add a aldehyde to the molecule O=C(Nc1ccccc1O)c1ccc2ncsc2c1.,O=C(Nc1ccccc1O)c1ccc2ncsc2c1,aldehyde
111347,Please add a amine to the molecule CO[C@H](CNC(=O)C1CC[NH+](C)CC1)c1cccc(Cl)c1.,CO[C@H](CNC(=O)C1CC[NH+](C)CC1)c1cccc(Cl)c1,amine
70529,Add a nitro to the molecule C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)N2CCCCCC2)cc1.,C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)N2CCCCCC2)cc1,nitro
143657,Add a benzene ring to the molecule O=c1c2ccccc2nc(SCc2cccc(Br)c2)n1C[C@H]1CCCO1.,O=c1c2ccccc2nc(SCc2cccc(Br)c2)n1C[C@H]1CCCO1,benzene ring
154153,Please add a halo to the molecule Cc1ccccc1-n1ncc(C(=O)NNC(=O)CC(C)C)c1C1CC1.,Cc1ccccc1-n1ncc(C(=O)NNC(=O)CC(C)C)c1C1CC1,halo
175511,Add a carboxyl to the molecule O=C(CNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1)OCc1ccccc1.,O=C(CNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1)OCc1ccccc1,carboxyl
100793,Please add a nitro to the molecule CC[C@@H](c1nnnn1C(C)(C)C)[NH+](Cc1cc2ccc(C)cc2[nH]c1=O)C1CCCCC1.,CC[C@@H](c1nnnn1C(C)(C)C)[NH+](Cc1cc2ccc(C)cc2[nH]c1=O)C1CCCCC1,nitro
118271,Add a hydroxyl to the molecule COC(OC)[C@H](C)NC(=O)[C@](C)(N)C(F)(F)F.,COC(OC)[C@H](C)NC(=O)[C@](C)(N)C(F)(F)F,hydroxyl
116111,Please add a aldehyde to the molecule Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)Nc1ccc(Cl)c(Cl)c1.,Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)Nc1ccc(Cl)c(Cl)c1,aldehyde
231122,Modify the molecule COc1cccc([C@H]2N=[NH+]C(=S)N2/N=C/c2ccc(OC(C)=O)c(OC)c2)c1 by adding a carboxyl.,COc1cccc([C@H]2N=[NH+]C(=S)N2/N=C/c2ccc(OC(C)=O)c(OC)c2)c1,carboxyl
115867,Add a hydroxyl to the molecule Nc1cccc(COc2cc(F)c([N+](=O)[O-])cc2F)n1.,Nc1cccc(COc2cc(F)c([N+](=O)[O-])cc2F)n1,hydroxyl
3264,Please add a hydroxyl to the molecule CCOC(=O)[C@H]1CCCC[NH+]1Cc1cc(=O)oc2cc(CC)c(Cl)cc12.,CCOC(=O)[C@H]1CCCC[NH+]1Cc1cc(=O)oc2cc(CC)c(Cl)cc12,hydroxyl
112584,Modify the molecule COC(=O)c1c(N)sc(C)c1-c1ccc(Cl)cc1Cl by adding a hydroxyl.,COC(=O)c1c(N)sc(C)c1-c1ccc(Cl)cc1Cl,hydroxyl
50482,Add a carboxyl to the molecule CC(=O)C[C@H]1CCCCCN1C(=O)c1ccc(C)c(Cl)c1.,CC(=O)C[C@H]1CCCCCN1C(=O)c1ccc(C)c(Cl)c1,carboxyl
170354,Add a halo to the molecule Cc1ccsc1CC[NH2+]C[C@@]1(O)CCCN(CC2CCCCC2)C1=O.,Cc1ccsc1CC[NH2+]C[C@@]1(O)CCCN(CC2CCCCC2)C1=O,halo
114012,Modify the molecule O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1 by adding a halo.,O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1,halo
28766,Please add a nitrile to the molecule [S-]c1cc(-c2ccccc2)nc(-c2cnccn2)n1.,[S-]c1cc(-c2ccccc2)nc(-c2cnccn2)n1,nitrile
229203,Add a thiol to the molecule COc1ccccc1/C=C/C=C1\N=C(c2c(-c3ccccc3)noc2C)OC1=O.,COc1ccccc1/C=C/C=C1\N=C(c2c(-c3ccccc3)noc2C)OC1=O,thiol
17928,Please add a amine to the molecule Cc1ccccc1C1=C[C@H]([C@H]2NC(c3cccc(F)c3)=NO2)N=N1.,Cc1ccccc1C1=C[C@H]([C@H]2NC(c3cccc(F)c3)=NO2)N=N1,amine
170469,Modify the molecule O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc2nnnn2c1 by adding a hydroxyl.,O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc2nnnn2c1,hydroxyl
120226,Add a aldehyde to the molecule O=C(c1ccccc1)C1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1.,O=C(c1ccccc1)C1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1,aldehyde
208523,Modify the molecule Cn1c(N)c(C(=O)COC(=O)/C=C/c2cccc(Br)c2)c(=O)n(C)c1=O by adding a nitro.,Cn1c(N)c(C(=O)COC(=O)/C=C/c2cccc(Br)c2)c(=O)n(C)c1=O,nitro
64894,Please add a aldehyde to the molecule C[C@@H]1CCCC[C@@H]1[NH+]1CCC(NCCc2nncn2C2CC2)CC1.,C[C@@H]1CCCC[C@@H]1[NH+]1CCC(NCCc2nncn2C2CC2)CC1,aldehyde
92310,Please add a carboxyl to the molecule C[C@H]1C[C@H](C)CN(S(=O)(=O)c2ccc(C(=O)NC[C@@H](c3ccco3)[NH+](C)C)cc2)C1.,C[C@H]1C[C@H](C)CN(S(=O)(=O)c2ccc(C(=O)NC[C@@H](c3ccco3)[NH+](C)C)cc2)C1,carboxyl
222294,Modify the molecule CC(C)OC(=O)N1CCC([NH2+][C@H]2CCCc3sccc32)CC1 by adding a amide.,CC(C)OC(=O)N1CCC([NH2+][C@H]2CCCc3sccc32)CC1,amide
215500,Please add a halo to the molecule COc1ccc(Cn2c3nc4ccccc4nc3c3c(=O)n(CCc4ccccc4)cnc32)cc1.,COc1ccc(Cn2c3nc4ccccc4nc3c3c(=O)n(CCc4ccccc4)cnc32)cc1,halo
62765,Please add a hydroxyl to the molecule Cc1nn(Cc2ccccc2)c(C)c1NC(=O)c1cc2c(Cl)cccc2n1C.,Cc1nn(Cc2ccccc2)c(C)c1NC(=O)c1cc2c(Cl)cccc2n1C,hydroxyl
56724,Please add a amide to the molecule c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1.,c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1,amide
161164,Add a benzene ring to the molecule CC(C)c1ccc(CN2CCc3nnc(CNS(=O)(=O)c4ccccc4)n3CC2)cc1.,CC(C)c1ccc(CN2CCc3nnc(CNS(=O)(=O)c4ccccc4)n3CC2)cc1,benzene ring
62995,Add a hydroxyl to the molecule CCc1noc(CN(C)c2cc[nH+]c(C(=O)NCc3ccccc3)c2)n1.,CCc1noc(CN(C)c2cc[nH+]c(C(=O)NCc3ccccc3)c2)n1,hydroxyl
17901,Add a aldehyde to the molecule CC[C@H]1CC[C@@H]([NH+](CC(=O)OC)C2CCOCC2)C1.,CC[C@H]1CC[C@@H]([NH+](CC(=O)OC)C2CCOCC2)C1,aldehyde
84366,Please add a amine to the molecule CCC(=O)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)CCN(C(=O)c1cccs1)C2.,CCC(=O)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)CCN(C(=O)c1cccs1)C2,amine
231849,Modify the molecule CCC[C@H]1C[NH2+]C(C)(C)CN1Cc1nccs1 by adding a nitrile.,CCC[C@H]1C[NH2+]C(C)(C)CN1Cc1nccs1,nitrile
147766,Add a amine to the molecule Cc1cc2ccccc2n1CC(=O)Nc1ccccc1C[NH+](C)C.,Cc1cc2ccccc2n1CC(=O)Nc1ccccc1C[NH+](C)C,amine
131537,Modify the molecule C[C@H](N[C@@H](c1cccc(Cl)c1)C1CCCC1)c1nccs1 by adding a hydroxyl.,C[C@H](N[C@@H](c1cccc(Cl)c1)C1CCCC1)c1nccs1,hydroxyl
181525,Add a amide to the molecule CS(=O)(=O)N1CCCN(CCOc2ccccc2)CC1.,CS(=O)(=O)N1CCCN(CCOc2ccccc2)CC1,amide
7712,Add a amide to the molecule CNC(=O)c1ccc(NC(=O)Nc2cnn(CC(C)C)c2)c(Cl)c1.,CNC(=O)c1ccc(NC(=O)Nc2cnn(CC(C)C)c2)c(Cl)c1,amide
138536,Add a benzene ring to the molecule CO[C@@]1(C)C[C@@H](N(C)Cc2cc(=O)n3nccc3[nH]2)C1(C)C.,CO[C@@]1(C)C[C@@H](N(C)Cc2cc(=O)n3nccc3[nH]2)C1(C)C,benzene ring
85147,Please add a hydroxyl to the molecule Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3.,Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3,hydroxyl
195220,Modify the molecule COCc1ccccc1[C@H](O)[C@@]1(C#N)CCOC1 by adding a hydroxyl.,COCc1ccccc1[C@H](O)[C@@]1(C#N)CCOC1,hydroxyl
140712,Add a amide to the molecule CCN(Cc1ccccc1C)C(=O)N[C@@H](C)c1ccc2c(c1)NC(=O)CO2.,CCN(Cc1ccccc1C)C(=O)N[C@@H](C)c1ccc2c(c1)NC(=O)CO2,amide
95511,Please add a carboxyl to the molecule Cc1cn(C)nc1C(=O)N(Cc1cccnc1)c1nc2c(C(C)C)cccc2s1.,Cc1cn(C)nc1C(=O)N(Cc1cccnc1)c1nc2c(C(C)C)cccc2s1,carboxyl
40276,Please add a amine to the molecule O=C(/C=C(\[O-])c1ccc2c(c1)OCO2)C(F)(F)F.,O=C(/C=C(\[O-])c1ccc2c(c1)OCO2)C(F)(F)F,amine
72328,Modify the molecule O=C(CCCS(=O)(=O)c1ccc(F)cc1)Nc1cccc(Cl)c1Cl by adding a amide.,O=C(CCCS(=O)(=O)c1ccc(F)cc1)Nc1cccc(Cl)c1Cl,amide
87585,Please add a amide to the molecule CC(C)(C)OC(=O)N1CC[C@H]([NH+]2CCCCCC2)C1.,CC(C)(C)OC(=O)N1CC[C@H]([NH+]2CCCCCC2)C1,amide
67527,Add a aldehyde to the molecule COc1cccc2cc(C(=O)N3CCC[C@H]3C[NH+]3CCCCC3)oc12.,COc1cccc2cc(C(=O)N3CCC[C@H]3C[NH+]3CCCCC3)oc12,aldehyde
82956,Please add a hydroxyl to the molecule CC(C)C[C@H]1COCCN1C(=O)NC[C@@H]1C[NH+](C)CCN1C.,CC(C)C[C@H]1COCCN1C(=O)NC[C@@H]1C[NH+](C)CCN1C,hydroxyl
136795,Modify the molecule Cc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1Cl by adding a benzene ring.,Cc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1Cl,benzene ring
208308,Please add a aldehyde to the molecule CCCC1=NN2C(=N)/C(=C/c3ccc(O)cc3)C(=O)N=C2S1.,CCCC1=NN2C(=N)/C(=C/c3ccc(O)cc3)C(=O)N=C2S1,aldehyde
21632,Please add a hydroxyl to the molecule O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2.,O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2,hydroxyl
5626,Add a amide to the molecule COCCCN(C)C(=O)NCC1(c2cccc(Cl)c2)CCOCC1.,COCCCN(C)C(=O)NCC1(c2cccc(Cl)c2)CCOCC1,amide
13565,Add a benzene ring to the molecule COC(C)(C)C[C@@H](C)NC(=O)NC1CCC(O)CC1.,COC(C)(C)C[C@@H](C)NC(=O)NC1CCC(O)CC1,benzene ring
171147,Please add a amine to the molecule CN(C)c1ccc(C(F)(F)F)cc1NC(=O)c1ccc(F)cc1.,CN(C)c1ccc(C(F)(F)F)cc1NC(=O)c1ccc(F)cc1,amine
33982,Please add a nitrile to the molecule COc1cc(C)ccc1NC(=O)N1CC[C@@H](C)C[C@H]1C.,COc1cc(C)ccc1NC(=O)N1CC[C@@H](C)C[C@H]1C,nitrile
102960,Add a carboxyl to the molecule COc1cc(OC)cc(-c2ccc(C(=O)[O-])o2)c1.,COc1cc(OC)cc(-c2ccc(C(=O)[O-])o2)c1,carboxyl
160767,Add a aldehyde to the molecule CCNC(=O)c1ccc(N(C)CCS(C)(=O)=O)[nH+]n1.,CCNC(=O)c1ccc(N(C)CCS(C)(=O)=O)[nH+]n1,aldehyde
230828,Add a nitro to the molecule COC[C@@H](C)NC(=O)NCCC(=O)Nc1ccc(C)cn1.,COC[C@@H](C)NC(=O)NCCC(=O)Nc1ccc(C)cn1,nitro
131073,Add a benzene ring to the molecule C=CCn1c([O-])c2ccc(C(=O)NC(C3CC3)C3CC3)cc2nc1=S.,C=CCn1c([O-])c2ccc(C(=O)NC(C3CC3)C3CC3)cc2nc1=S,benzene ring
65258,Modify the molecule CC(C)(C)n1cc(NC(=O)N2CCCC[C@H]2Cc2ccccc2)cn1 by adding a amine.,CC(C)(C)n1cc(NC(=O)N2CCCC[C@H]2Cc2ccccc2)cn1,amine
63413,Modify the molecule O=C1[C@@H]2Cc3c([nH]c4ccccc34)CN2C(=O)CN1/N=C/c1c(F)cccc1Cl by adding a hydroxyl.,O=C1[C@@H]2Cc3c([nH]c4ccccc34)CN2C(=O)CN1/N=C/c1c(F)cccc1Cl,hydroxyl
101529,Modify the molecule CS(=O)(=O)NCC[C@H]1CCCCN1C(=O)Cc1ccc[nH]1 by adding a aldehyde.,CS(=O)(=O)NCC[C@H]1CCCCN1C(=O)Cc1ccc[nH]1,aldehyde
178131,Please add a hydroxyl to the molecule CCn1c(-c2ccc3c(c2)OCCO3)cnc1SCC(=O)NC1CC1.,CCn1c(-c2ccc3c(c2)OCCO3)cnc1SCC(=O)NC1CC1,hydroxyl
89533,Modify the molecule C/[NH+]=C(/NC[C@H]1C[C@@H]1c1ccccc1)N[C@@H]1CC[C@H](SC)C1 by adding a hydroxyl.,C/[NH+]=C(/NC[C@H]1C[C@@H]1c1ccccc1)N[C@@H]1CC[C@H](SC)C1,hydroxyl
190897,Add a aldehyde to the molecule O=c1c2nnc3ncnn3c2ccn1-c1ccc([N+](=O)[O-])cc1.,O=c1c2nnc3ncnn3c2ccn1-c1ccc([N+](=O)[O-])cc1,aldehyde
24112,Modify the molecule Cc1cccnc1CN1C[C@@H](C)[C@@H]1c1ccccc1 by adding a nitro.,Cc1cccnc1CN1C[C@@H](C)[C@@H]1c1ccccc1,nitro
71106,Add a amide to the molecule C[NH2+][C@@H](C)c1ccc(S(=O)(=O)NC[C@]2(C)CCCO2)cc1.,C[NH2+][C@@H](C)c1ccc(S(=O)(=O)NC[C@]2(C)CCCO2)cc1,amide
143189,Modify the molecule C(=N/c1cccn2cc(-c3ccccc3)nc12)\c1cccs1 by adding a nitro.,C(=N/c1cccn2cc(-c3ccccc3)nc12)\c1cccs1,nitro
107624,Modify the molecule C[NH2+][C@@H]1[C@@H](Sc2ccccc2F)CCC1(C)C by adding a aldehyde.,C[NH2+][C@@H]1[C@@H](Sc2ccccc2F)CCC1(C)C,aldehyde
75899,Add a amine to the molecule CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2.,CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2,amine
196243,Please add a amine to the molecule COc1ccc2c(c1)C1=NN(C(C)=O)[C@@H](c3ccc(C)cc3)[C@@H]1CC2.,COc1ccc2c(c1)C1=NN(C(C)=O)[C@@H](c3ccc(C)cc3)[C@@H]1CC2,amine
226567,Modify the molecule COC[C@@](C)(CCO)[NH2+]Cc1nnsc1Cl by adding a benzene ring.,COC[C@@](C)(CCO)[NH2+]Cc1nnsc1Cl,benzene ring
221758,Modify the molecule Cc1[nH]c2ccccc2c1C(=O)C(=O)Nc1ccc2ccccc2n1 by adding a benzene ring.,Cc1[nH]c2ccccc2c1C(=O)C(=O)Nc1ccc2ccccc2n1,benzene ring
83554,Modify the molecule C=CC[C@@H](C)[C@@H](C)[NH2+][C@@H]1CCN(c2cnn(C)c2)C1=O by adding a halo.,C=CC[C@@H](C)[C@@H](C)[NH2+][C@@H]1CCN(c2cnn(C)c2)C1=O,halo
234395,Please add a halo to the molecule Cc1cc(C[C@H](C)N[C@H]2CCOc3ccc(F)cc32)n[nH]1.,Cc1cc(C[C@H](C)N[C@H]2CCOc3ccc(F)cc32)n[nH]1,halo
137311,Modify the molecule CCC[C@H]1C(=O)NCCN1Cc1cn(Cc2ccccc2)nc1-c1cccnc1 by adding a benzene ring.,CCC[C@H]1C(=O)NCCN1Cc1cn(Cc2ccccc2)nc1-c1cccnc1,benzene ring
97883,Please add a benzene ring to the molecule COc1ccccc1NS(=O)(=O)c1cccc(NC(=O)Nc2ccccc2)c1.,COc1ccccc1NS(=O)(=O)c1cccc(NC(=O)Nc2ccccc2)c1,benzene ring
152010,Please add a aldehyde to the molecule O=C(c1cnccn1)N1CC(C(=O)N(Cc2ccccc2)Cc2ccccc2)C1.,O=C(c1cnccn1)N1CC(C(=O)N(Cc2ccccc2)Cc2ccccc2)C1,aldehyde
233266,Add a aldehyde to the molecule O=C(NN1CCOCC1)[C@H]1[C@H]2C=C[C@H](CC2)[C@H]1C(=O)[O-].,O=C(NN1CCOCC1)[C@H]1[C@H]2C=C[C@H](CC2)[C@H]1C(=O)[O-],aldehyde
34574,Modify the molecule COc1cc(NCc2cnc(-c3cccnc3)s2)cc(OC)c1 by adding a benzene ring.,COc1cc(NCc2cnc(-c3cccnc3)s2)cc(OC)c1,benzene ring
159735,Add a halo to the molecule C[NH+]1CCC(N(Cc2ccco2)C(=O)NCCC2CCCCC2)CC1.,C[NH+]1CCC(N(Cc2ccco2)C(=O)NCCC2CCCCC2)CC1,halo
11498,Modify the molecule C[C@H](CNC(=O)NCc1cnn(C)c1)c1nc(-c2ccccc2)no1 by adding a halo.,C[C@H](CNC(=O)NCc1cnn(C)c1)c1nc(-c2ccccc2)no1,halo
15357,Modify the molecule Cc1nc(CCC[S@](=O)Cc2cnc(C)s2)cs1 by adding a hydroxyl.,Cc1nc(CCC[S@](=O)Cc2cnc(C)s2)cs1,hydroxyl
47969,Please add a amide to the molecule CCC[C@@H]1CC[C@H](C#N)[C@H]([NH+](C)CC)C1.,CCC[C@@H]1CC[C@H](C#N)[C@H]([NH+](C)CC)C1,amide
144659,Please add a hydroxyl to the molecule C[C@H]1C[C@H](C)C[NH+](C(C)(C)CNC(=O)NCc2cccs2)C1.,C[C@H]1C[C@H](C)C[NH+](C(C)(C)CNC(=O)NCc2cccs2)C1,hydroxyl
118831,Please add a benzene ring to the molecule O=C([C@@H]1CCCC[NH+]1Cc1ccccc1OCC1CC1)N1CCOCC1.,O=C([C@@H]1CCCC[NH+]1Cc1ccccc1OCC1CC1)N1CCOCC1,benzene ring
121923,Add a nitro to the molecule C[NH2+][C@@H]1c2ccccc2CCC[C@H]1SCC[NH+](C)C.,C[NH2+][C@@H]1c2ccccc2CCC[C@H]1SCC[NH+](C)C,nitro
93161,Modify the molecule O=C(Cc1ccc2ccccc2c1)N[C@@H]1CCc2ccccc2C1 by adding a amide.,O=C(Cc1ccc2ccccc2c1)N[C@@H]1CCc2ccccc2C1,amide
48271,Add a carboxyl to the molecule Cc1nc(CC(=O)N2CCN(C/C=C/c3ccccc3)CC2)cs1.,Cc1nc(CC(=O)N2CCN(C/C=C/c3ccccc3)CC2)cs1,carboxyl
24079,Modify the molecule CN1C(=O)C(=Cc2ccc([N+](=O)[O-])o2)C(=O)N(C)C1=S by adding a amide.,CN1C(=O)C(=Cc2ccc([N+](=O)[O-])o2)C(=O)N(C)C1=S,amide
221667,Add a aldehyde to the molecule Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1.,Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1,aldehyde
95492,Add a amide to the molecule COc1ccc([C@@H]2C[C@@H](C)[NH+](CC(=O)NCc3cccs3)C2)cc1.,COc1ccc([C@@H]2C[C@@H](C)[NH+](CC(=O)NCc3cccs3)C2)cc1,amide
137973,Modify the molecule CCOc1ccc(C)cc1S(=O)(=O)N1CCC[C@H](N2CCNC2=O)C1 by adding a hydroxyl.,CCOc1ccc(C)cc1S(=O)(=O)N1CCC[C@H](N2CCNC2=O)C1,hydroxyl
228161,Modify the molecule C[C@@H](c1ccccc1F)N(C)C(=O)c1cn(Cc2cccnc2)nn1 by adding a carboxyl.,C[C@@H](c1ccccc1F)N(C)C(=O)c1cn(Cc2cccnc2)nn1,carboxyl
168575,Modify the molecule CSc1ncc(Cl)c(C(=O)O[C@@H](C)C(=O)c2ccc(Br)cc2)n1 by adding a benzene ring.,CSc1ncc(Cl)c(C(=O)O[C@@H](C)C(=O)c2ccc(Br)cc2)n1,benzene ring
42288,Modify the molecule CC(C)C[C@@H]1C[NH+]=C(N)N1C1CCCC1 by adding a hydroxyl.,CC(C)C[C@@H]1C[NH+]=C(N)N1C1CCCC1,hydroxyl
17486,Please add a nitrile to the molecule C[C@H]1CCN(C(=O)c2ccn(-c3ccc(Cl)cc3Cl)n2)C[C@H]1O.,C[C@H]1CCN(C(=O)c2ccn(-c3ccc(Cl)cc3Cl)n2)C[C@H]1O,nitrile
51093,Modify the molecule CC(=O)c1cccc(NC(=O)[C@H]2Cc3ccccc3C(=O)O2)c1 by adding a benzene ring.,CC(=O)c1cccc(NC(=O)[C@H]2Cc3ccccc3C(=O)O2)c1,benzene ring
32707,Please add a aldehyde to the molecule Cc1ccc(C(=O)N2CCCC[C@H]2c2ccccn2)cc1N1CCNC1=O.,Cc1ccc(C(=O)N2CCCC[C@H]2c2ccccn2)cc1N1CCNC1=O,aldehyde
176922,Please add a amide to the molecule CCC[NH+](C)C[C@H]1CCN(C(=O)c2sccc2-n2c(C)ccc2C)C1.,CCC[NH+](C)C[C@H]1CCN(C(=O)c2sccc2-n2c(C)ccc2C)C1,amide
225075,Modify the molecule CNS(=O)(=O)c1ccc(NC(=O)CSc2ccccc2)cc1 by adding a amide.,CNS(=O)(=O)c1ccc(NC(=O)CSc2ccccc2)cc1,amide
11157,Please add a benzene ring to the molecule C=CCSC1=NC(=O)[C@@H]2C(=N1)NC(C)=C(C(=O)OCC)[C@H]2c1ccccc1.,C=CCSC1=NC(=O)[C@@H]2C(=N1)NC(C)=C(C(=O)OCC)[C@H]2c1ccccc1,benzene ring
113395,Add a nitro to the molecule CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1.,CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1,nitro
158672,Please add a halo to the molecule Cc1cc(C(=O)CSc2nnnn2C)c(C)n1-c1ccccc1.,Cc1cc(C(=O)CSc2nnnn2C)c(C)n1-c1ccccc1,halo
138347,Please add a benzene ring to the molecule CC1CCN(c2ccc(C(=O)OCCC(=O)N(C)C)cc2[N+](=O)[O-])CC1.,CC1CCN(c2ccc(C(=O)OCCC(=O)N(C)C)cc2[N+](=O)[O-])CC1,benzene ring
67670,Modify the molecule Cc1cc(C)c(C(=O)C[n+]2ccn(C)c2C(=O)c2cccs2)cc1C by adding a benzene ring.,Cc1cc(C)c(C(=O)C[n+]2ccn(C)c2C(=O)c2cccs2)cc1C,benzene ring
232363,Modify the molecule COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1 by adding a carboxyl.,COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1,carboxyl
220853,Please add a hydroxyl to the molecule CC(C)CCNC(=O)NC[C@@H](C)[NH+]1CCC(C)CC1.,CC(C)CCNC(=O)NC[C@@H](C)[NH+]1CCC(C)CC1,hydroxyl
225222,Add a benzene ring to the molecule O=C(COc1ccc(F)cc1F)c1ccc2c(c1)CCCC2.,O=C(COc1ccc(F)cc1F)c1ccc2c(c1)CCCC2,benzene ring
147526,Modify the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1 by adding a benzene ring.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1,benzene ring
128944,Please add a nitrile to the molecule CC(C)COc1ccc(NC(=O)[C@@H]2CCCN2C(N)=O)cc1Cl.,CC(C)COc1ccc(NC(=O)[C@@H]2CCCN2C(N)=O)cc1Cl,nitrile
45990,Add a hydroxyl to the molecule CCn1c(C[NH+]2CCCC2)nnc1C1CC[NH+](Cc2coc(C)n2)CC1.,CCn1c(C[NH+]2CCCC2)nnc1C1CC[NH+](Cc2coc(C)n2)CC1,hydroxyl
28424,Add a nitrile to the molecule O=C(N[C@H]1C=C[C@H](C(=O)[O-])C1)c1ccc(Cl)cc1Cl.,O=C(N[C@H]1C=C[C@H](C(=O)[O-])C1)c1ccc(Cl)cc1Cl,nitrile
209,Please add a hydroxyl to the molecule CCOC(=O)c1cccc(NC(=O)c2cn[nH]c2C)c1.,CCOC(=O)c1cccc(NC(=O)c2cn[nH]c2C)c1,hydroxyl
154886,Modify the molecule O=c1n(CCl)nc2ccccn12 by adding a hydroxyl.,O=c1n(CCl)nc2ccccn12,hydroxyl
84213,Modify the molecule C[C@@H](Cn1cccn1)NC(=O)NC[C@H](O)C[NH+]1CCCCC1 by adding a amine.,C[C@@H](Cn1cccn1)NC(=O)NC[C@H](O)C[NH+]1CCCCC1,amine
230106,Please add a halo to the molecule C[C@H]1CCCN(C(=O)NCC(N)=[NH2+])C1.,C[C@H]1CCCN(C(=O)NCC(N)=[NH2+])C1,halo
202974,Add a benzene ring to the molecule CCc1ccc(Cl)c(CC)c1NC(=O)NCc1nnc2n1CCCCC2.,CCc1ccc(Cl)c(CC)c1NC(=O)NCc1nnc2n1CCCCC2,benzene ring
41004,Add a carboxyl to the molecule CCc1ccc(-c2csc(NC(=O)c3ccccc3SCC(=O)N3CCCC3)n2)cc1.,CCc1ccc(-c2csc(NC(=O)c3ccccc3SCC(=O)N3CCCC3)n2)cc1,carboxyl
18785,Add a hydroxyl to the molecule COc1ccc([C@@H]2N=C(c3cccc(Br)c3)C[C@@H](c3ccccc3O)[NH2+]2)cc1.,COc1ccc([C@@H]2N=C(c3cccc(Br)c3)C[C@@H](c3ccccc3O)[NH2+]2)cc1,hydroxyl
11734,Modify the molecule Cn1c(C2CCN(C(=O)c3ccc4cc[nH]c4c3)CC2)n[nH]c1=S by adding a hydroxyl.,Cn1c(C2CCN(C(=O)c3ccc4cc[nH]c4c3)CC2)n[nH]c1=S,hydroxyl
85041,Add a halo to the molecule C[C@H](C(=O)NN)[NH+](C)CCc1cccs1.,C[C@H](C(=O)NN)[NH+](C)CCc1cccs1,halo
59025,Add a amide to the molecule Cc1ccc(-c2ccc(=O)n(CC(=O)NCc3ccco3)n2)c(C)c1.,Cc1ccc(-c2ccc(=O)n(CC(=O)NCc3ccco3)n2)c(C)c1,amide
229937,Modify the molecule O=C(CSc1ccc2c(c1)OCCCO2)NCCc1ccc(F)cc1 by adding a amide.,O=C(CSc1ccc2c(c1)OCCCO2)NCCc1ccc(F)cc1,amide
75646,Please add a hydroxyl to the molecule CCCC1=C(C(=O)OCC)[C@@H](c2cccc(C)c2)NC(=S)N1.,CCCC1=C(C(=O)OCC)[C@@H](c2cccc(C)c2)NC(=S)N1,hydroxyl
116084,Please add a amide to the molecule Cc1nc(C(=O)NC2CCC(C(=O)OC(C)(C)C)CC2)c(=O)[nH]c1C.,Cc1nc(C(=O)NC2CCC(C(=O)OC(C)(C)C)CC2)c(=O)[nH]c1C,amide
42889,Add a benzene ring to the molecule Cc1c(CCC(=O)NCc2ccnc(OC3CCC3)c2)cnn1C.,Cc1c(CCC(=O)NCc2ccnc(OC3CCC3)c2)cnn1C,benzene ring
161144,Please add a benzene ring to the molecule COc1ccccc1CNC(=O)CS(=O)(=O)c1ccc(C)cc1.,COc1ccccc1CNC(=O)CS(=O)(=O)c1ccc(C)cc1,benzene ring
120345,Please add a hydroxyl to the molecule [S-]c1nnc(C2CCCCC2)n1/N=C/c1ccco1.,[S-]c1nnc(C2CCCCC2)n1/N=C/c1ccco1,hydroxyl
138507,Please add a hydroxyl to the molecule C[C@H]1OCC[C@@H]1C(=O)N(C)c1ccc(C#N)cc1.,C[C@H]1OCC[C@@H]1C(=O)N(C)c1ccc(C#N)cc1,hydroxyl
184213,Add a hydroxyl to the molecule C[C@@H]1CC[C@@H](Nc2ccc(S(N)(=O)=O)c(N)c2)[C@H](C)C1.,C[C@@H]1CC[C@@H](Nc2ccc(S(N)(=O)=O)c(N)c2)[C@H](C)C1,hydroxyl
133421,Add a amide to the molecule CCN(CC)C(=O)c1cccc(NC(=O)NCc2cn3c(C)cccc3[nH+]2)c1.,CCN(CC)C(=O)c1cccc(NC(=O)NCc2cn3c(C)cccc3[nH+]2)c1,amide
149660,Modify the molecule COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1 by adding a carboxyl.,COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1,carboxyl
127699,Please add a benzene ring to the molecule CCC[NH2+][C@@H](c1cncnc1)[C@@](C)(CC)N1CCOCC1.,CCC[NH2+][C@@H](c1cncnc1)[C@@](C)(CC)N1CCOCC1,benzene ring
68112,Modify the molecule CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1 by adding a carboxyl.,CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1,carboxyl
107155,Please add a amide to the molecule Cc1csc([C@@H](C)NC(=O)NC[C@H](C)[NH+]2CCc3ccccc3C2)n1.,Cc1csc([C@@H](C)NC(=O)NC[C@H](C)[NH+]2CCc3ccccc3C2)n1,amide
29773,Modify the molecule COC[C@H]1CN(c2ccc(Cl)cn2)CCO1 by adding a nitrile.,COC[C@H]1CN(c2ccc(Cl)cn2)CCO1,nitrile
23966,Modify the molecule Brc1cccc([C@H]2CC(c3ccc(I)cc3)=Nc3ncnn32)c1 by adding a benzene ring.,Brc1cccc([C@H]2CC(c3ccc(I)cc3)=Nc3ncnn32)c1,benzene ring
79148,Add a amide to the molecule CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N.,CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N,amide
243045,Add a halo to the molecule O=C(NCCc1ccco1)c1cc(NC(=O)C2CC2)n(-c2ccccc2)n1.,O=C(NCCc1ccco1)c1cc(NC(=O)C2CC2)n(-c2ccccc2)n1,halo
35849,Please add a hydroxyl to the molecule Cc1ccc(CCC(=O)NCCc2nc3ccc(F)cc3n2C)cc1.,Cc1ccc(CCC(=O)NCCc2nc3ccc(F)cc3n2C)cc1,hydroxyl
75674,Modify the molecule COc1ccc([C@@H](NC(=O)c2ccc3c(c2)nnn3C)C2CCOCC2)cc1 by adding a amide.,COc1ccc([C@@H](NC(=O)c2ccc3c(c2)nnn3C)C2CCOCC2)cc1,amide
62441,Modify the molecule C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1 by adding a hydroxyl.,C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1,hydroxyl
47172,Modify the molecule CC[C@H](O)C[NH+](CC(F)(F)F)C1CCC1 by adding a benzene ring.,CC[C@H](O)C[NH+](CC(F)(F)F)C1CCC1,benzene ring
217003,Modify the molecule Cc1ccc2oc(-c3ccc4c(c3)OCO4)c/c(=[NH+]/[C@H](C)C(=O)[O-])c2c1 by adding a hydroxyl.,Cc1ccc2oc(-c3ccc4c(c3)OCO4)c/c(=[NH+]/[C@H](C)C(=O)[O-])c2c1,hydroxyl
131676,Please add a nitro to the molecule CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1.,CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1,nitro
111631,Modify the molecule Cc1cc2ncc([C@@H](C)[NH2+][C@H]3CCc4c(O)cccc43)c(C)n2n1 by adding a benzene ring.,Cc1cc2ncc([C@@H](C)[NH2+][C@H]3CCc4c(O)cccc43)c(C)n2n1,benzene ring
71370,Modify the molecule COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC by adding a amide.,COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC,amide
146036,Modify the molecule CC(=O)CC(=O)Nc1ccc(C2=NCCO2)cc1 by adding a amine.,CC(=O)CC(=O)Nc1ccc(C2=NCCO2)cc1,amine
156559,Add a benzene ring to the molecule Cc1ccc2c(c1)=C[C@@H](CN(C(=O)c1ccc(C(C)(C)C)cc1)C(C)C)C(=O)[NH+]=2.,Cc1ccc2c(c1)=C[C@@H](CN(C(=O)c1ccc(C(C)(C)C)cc1)C(C)C)C(=O)[NH+]=2,benzene ring
176739,Modify the molecule CN1C(=O)NC2(CCN(C(=O)CCCc3nc4cc(Cl)ccc4n3C)CC2)C1=O by adding a nitrile.,CN1C(=O)NC2(CCN(C(=O)CCCc3nc4cc(Cl)ccc4n3C)CC2)C1=O,nitrile
165840,Modify the molecule CCN(C(=O)[C@H](C)SCc1nc2sc(C)c(C)c2c(=O)[nH]1)C1CCCCC1 by adding a amide.,CCN(C(=O)[C@H](C)SCc1nc2sc(C)c(C)c2c(=O)[nH]1)C1CCCCC1,amide
225192,Add a benzene ring to the molecule Cc1noc(C)c1CN[C@H](C)c1ccccc1C(F)(F)F.,Cc1noc(C)c1CN[C@H](C)c1ccccc1C(F)(F)F,benzene ring
139022,Please add a amide to the molecule Nc1ccc(SCc2nc(-c3ccco3)no2)cc1F.,Nc1ccc(SCc2nc(-c3ccco3)no2)cc1F,amide
138000,Modify the molecule CCN(C(=O)c1ccc(F)cc1)C1CCCC1 by adding a benzene ring.,CCN(C(=O)c1ccc(F)cc1)C1CCCC1,benzene ring
65658,Add a thiol to the molecule CCC(CC)N(C)c1nc(C(F)(F)F)ccc1/C(N)=N/O.,CCC(CC)N(C)c1nc(C(F)(F)F)ccc1/C(N)=N/O,thiol
224442,Please add a thiol to the molecule CC(C)(C)n1ncc2c(=O)[nH]c(NCC3([NH+]4CCSCC4)CCCC3)nc21.,CC(C)(C)n1ncc2c(=O)[nH]c(NCC3([NH+]4CCSCC4)CCCC3)nc21,thiol
176518,Add a halo to the molecule O=C(Cc1cccc2ccccc12)NNC(=O)c1ccc(NC(=O)C2CCCCC2)cc1.,O=C(Cc1cccc2ccccc12)NNC(=O)c1ccc(NC(=O)C2CCCCC2)cc1,halo
122324,Please add a amine to the molecule Cn1cc(Br)cc(NC(=O)N2CCC[C@H]2CC(C)(C)C)c1=O.,Cn1cc(Br)cc(NC(=O)N2CCC[C@H]2CC(C)(C)C)c1=O,amine
94566,Add a benzene ring to the molecule NNC(=O)c1cccc2c1-c1ccccc1C2=O.,NNC(=O)c1cccc2c1-c1ccccc1C2=O,benzene ring
143453,Modify the molecule c1ccc2nc(N3CCCCC3)c(C[NH+]3CCCC[C@H]3c3ncon3)cc2c1 by adding a halo.,c1ccc2nc(N3CCCCC3)c(C[NH+]3CCCC[C@H]3c3ncon3)cc2c1,halo
92872,Modify the molecule CC1(C)CCC[C@H]1[NH2+]Cc1cc2c(cc1Br)OCO2 by adding a benzene ring.,CC1(C)CCC[C@H]1[NH2+]Cc1cc2c(cc1Br)OCO2,benzene ring
226597,Please add a amide to the molecule CCOC[C@@H](O)CNc1nc2ccccc2c(=O)[nH]1.,CCOC[C@@H](O)CNc1nc2ccccc2c(=O)[nH]1,amide
198148,Modify the molecule CN(C(=O)Cc1c(F)cccc1Cl)[C@H]1CCc2ccccc21 by adding a benzene ring.,CN(C(=O)Cc1c(F)cccc1Cl)[C@H]1CCc2ccccc21,benzene ring
231874,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]([S@](=O)c2ccc(F)c(F)c2)C1 by adding a hydroxyl.,CC(C)(C)OC(=O)N1CCC[C@@H]([S@](=O)c2ccc(F)c(F)c2)C1,hydroxyl
168208,Modify the molecule CN(CCNS(C)(=O)=O)Cc1ccccc1C#N by adding a benzene ring.,CN(CCNS(C)(=O)=O)Cc1ccccc1C#N,benzene ring
181700,Modify the molecule CCc1ccccc1-n1cc([O-])c(C(=O)N2CC[S@](=O)C(C)(C)C2)n1 by adding a nitro.,CCc1ccccc1-n1cc([O-])c(C(=O)N2CC[S@](=O)C(C)(C)C2)n1,nitro
7999,Add a aldehyde to the molecule NC(=O)N1CCC[C@H](C(=O)NCc2cc(-c3ccco3)on2)C1.,NC(=O)N1CCC[C@H](C(=O)NCc2cc(-c3ccco3)on2)C1,aldehyde
16037,Please add a aldehyde to the molecule O=C(Nc1ccc2c3c(c(=O)[nH]c2c1)CCCC3)c1ccc(Cl)cc1.,O=C(Nc1ccc2c3c(c(=O)[nH]c2c1)CCCC3)c1ccc(Cl)cc1,aldehyde
6558,Please add a amine to the molecule COc1ccc(/C=[NH+]/C[C@H]2COc3ccccc3O2)cc1OC.,COc1ccc(/C=[NH+]/C[C@H]2COc3ccccc3O2)cc1OC,amine
34139,Add a hydroxyl to the molecule O=C(CSc1ccc(Cl)nn1)Nc1ccc(Cl)cn1.,O=C(CSc1ccc(Cl)nn1)Nc1ccc(Cl)cn1,hydroxyl
222950,Modify the molecule CC(C)[C@@H](CO)NC(=O)N[C@H](Cc1ccccc1)c1ccccc1F by adding a nitro.,CC(C)[C@@H](CO)NC(=O)N[C@H](Cc1ccccc1)c1ccccc1F,nitro
230709,Add a benzene ring to the molecule C[C@@H]([NH2+][C@H](C)c1cccc(OCC(=O)N(C)C)c1)c1ccccc1.,C[C@@H]([NH2+][C@H](C)c1cccc(OCC(=O)N(C)C)c1)c1ccccc1,benzene ring
65252,Modify the molecule CC(C)c1cc(=O)[nH]c(SCC(=O)[O-])n1 by adding a nitro.,CC(C)c1cc(=O)[nH]c(SCC(=O)[O-])n1,nitro
114471,Add a benzene ring to the molecule Cc1ccc(S(=O)(=O)NC[C@H]2O[C@@H](CO)[C@@H](O)[C@H]2N2CCN(c3cccc[nH+]3)CC2)cc1.,Cc1ccc(S(=O)(=O)NC[C@H]2O[C@@H](CO)[C@@H](O)[C@H]2N2CCN(c3cccc[nH+]3)CC2)cc1,benzene ring
106276,Please add a amide to the molecule Cc1nn(Cc2ccccc2Cl)c(C)c1C[NH2+][C@H]1CCS(=O)(=O)C1.,Cc1nn(Cc2ccccc2Cl)c(C)c1C[NH2+][C@H]1CCS(=O)(=O)C1,amide
37231,Modify the molecule CCOC(=O)c1sc2nc(SC)nc(-c3ccc(Cl)cc3)c2c1N by adding a benzene ring.,CCOC(=O)c1sc2nc(SC)nc(-c3ccc(Cl)cc3)c2c1N,benzene ring
160536,Please add a aldehyde to the molecule CCCN(C)c1ncnc2c1oc1ccccc12.,CCCN(C)c1ncnc2c1oc1ccccc12,aldehyde
11517,Modify the molecule CC[NH+]1CCC[C@@H]1CN(Cc1cc2cccc(C)c2[nH]c1=O)C(=O)Nc1cccc(Cl)c1 by adding a amide.,CC[NH+]1CCC[C@@H]1CN(Cc1cc2cccc(C)c2[nH]c1=O)C(=O)Nc1cccc(Cl)c1,amide
78353,Add a carboxyl to the molecule CCC(=O)Nc1ccc(NC(=O)CBr)cc1.,CCC(=O)Nc1ccc(NC(=O)CBr)cc1,carboxyl
187154,Modify the molecule Cc1cc(OCC(=O)N[C@H](C)CCc2ccccc2)ccc1Cl by adding a hydroxyl.,Cc1cc(OCC(=O)N[C@H](C)CCc2ccccc2)ccc1Cl,hydroxyl
146560,Modify the molecule Cc1ccc(CNC(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1F by adding a amide.,Cc1ccc(CNC(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1F,amide
25651,Please add a nitrile to the molecule CS(=O)(=O)c1cccc(C(=O)N2CCC[C@H]2c2nnc3n2CCCCC3)c1.,CS(=O)(=O)c1cccc(C(=O)N2CCC[C@H]2c2nnc3n2CCCCC3)c1,nitrile
13941,Add a hydroxyl to the molecule C[NH+](C)CCO[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C.,C[NH+](C)CCO[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C,hydroxyl
85009,Modify the molecule Nc1ccc2c(c1)CN(C=O)C2 by adding a carboxyl.,Nc1ccc2c(c1)CN(C=O)C2,carboxyl
163206,Please add a benzene ring to the molecule CCC[C@H]1C[C@@H]1NC(=O)/C=C/c1ccc(-n2ccnc2)cc1.,CCC[C@H]1C[C@@H]1NC(=O)/C=C/c1ccc(-n2ccnc2)cc1,benzene ring
154855,Modify the molecule CCC[C@@H](C)NC(=O)c1cc(S(=O)(=O)Nc2ccc(C)cc2)ccc1C by adding a benzene ring.,CCC[C@@H](C)NC(=O)c1cc(S(=O)(=O)Nc2ccc(C)cc2)ccc1C,benzene ring
80488,Please add a nitro to the molecule C=CCc1cc(C=O)ccc1OCCc1ccccc1.,C=CCc1cc(C=O)ccc1OCCc1ccccc1,nitro
199410,Please add a hydroxyl to the molecule C[C@@H]1C[C@H](Nc2cccc(N3CCCC3=O)c2)CS1.,C[C@@H]1C[C@H](Nc2cccc(N3CCCC3=O)c2)CS1,hydroxyl
132281,Modify the molecule CC[NH+]1CCC[C@@H]1C[NH+](C)Cc1ccc(N)c(C)c1 by adding a hydroxyl.,CC[NH+]1CCC[C@@H]1C[NH+](C)Cc1ccc(N)c(C)c1,hydroxyl
223270,Modify the molecule C[C@H](C(=O)N(C)CC12CC3CC(CC(C3)C1)C2)N1C(=O)[C@H]2CCCC[C@@H]2C1=O by adding a amide.,C[C@H](C(=O)N(C)CC12CC3CC(CC(C3)C1)C2)N1C(=O)[C@H]2CCCC[C@@H]2C1=O,amide
222211,Modify the molecule CCc1ccc(Nc2nn[nH]c2C(=O)NCc2cc(F)cc(F)c2)cc1 by adding a benzene ring.,CCc1ccc(Nc2nn[nH]c2C(=O)NCc2cc(F)cc(F)c2)cc1,benzene ring
211512,Please add a carboxyl to the molecule O=C(CCn1cnc2c(Cl)cc(Cl)cc2c1=O)c1ccc(F)cc1.,O=C(CCn1cnc2c(Cl)cc(Cl)cc2c1=O)c1ccc(F)cc1,carboxyl
59710,Add a aldehyde to the molecule COc1cc(C2CC(C(=O)[O-])C2)ccc1Br.,COc1cc(C2CC(C(=O)[O-])C2)ccc1Br,aldehyde
232657,Please add a benzene ring to the molecule CCN1C(=O)N=C(N)[C@@H]1c1cc(OC)c(OC)cc1Br.,CCN1C(=O)N=C(N)[C@@H]1c1cc(OC)c(OC)cc1Br,benzene ring
205764,Please add a amide to the molecule CCOC(=O)NNC(=O)C[C@H]1Sc2ccc(Cl)cc2NC1=O.,CCOC(=O)NNC(=O)C[C@H]1Sc2ccc(Cl)cc2NC1=O,amide
102179,Modify the molecule COc1cc([C@@H]2Oc3c(OC)cc(/C=C/C(=O)[O-])cc3[C@@H]2CO)ccc1O by adding a carboxyl.,COc1cc([C@@H]2Oc3c(OC)cc(/C=C/C(=O)[O-])cc3[C@@H]2CO)ccc1O,carboxyl
172047,Add a nitro to the molecule Cc1nc(C[NH2+][C@H]2CCCc3c2cnn3C)c(C)s1.,Cc1nc(C[NH2+][C@H]2CCCc3c2cnn3C)c(C)s1,nitro
142977,Modify the molecule C[C@@H](CC1CCCCC1)C(=O)Nc1nccs1 by adding a amine.,C[C@@H](CC1CCCCC1)C(=O)Nc1nccs1,amine
237088,Add a amide to the molecule O=C(OCc1cc(Cl)c2c(c1)OCCO2)C1CCN(C(=O)c2ccsc2)CC1.,O=C(OCc1cc(Cl)c2c(c1)OCCO2)C1CCN(C(=O)c2ccsc2)CC1,amide
81724,Add a hydroxyl to the molecule Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)[C@H]2CCO[C@@H]2C)c(C)c1.,Cc1ccc(NC(=O)[C@@H]2CSCN2C(=O)[C@H]2CCO[C@@H]2C)c(C)c1,hydroxyl
184646,Please add a carboxyl to the molecule C=CCO[C@H](C)C(=O)N[C@@H](c1cccs1)C1CCCC1.,C=CCO[C@H](C)C(=O)N[C@@H](c1cccs1)C1CCCC1,carboxyl
99886,Add a benzene ring to the molecule Cc1c(CO[C@H]2CC[C@H]([NH3+])C2)cccc1[N+](=O)[O-].,Cc1c(CO[C@H]2CC[C@H]([NH3+])C2)cccc1[N+](=O)[O-],benzene ring
159802,Modify the molecule NC(=O)N1CCCN(S(=O)(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 by adding a hydroxyl.,NC(=O)N1CCCN(S(=O)(=O)c2cc(C(F)(F)F)ccc2Cl)CC1,hydroxyl
121069,Please add a hydroxyl to the molecule CCC[NH+](Cc1cccc2cn[nH]c12)[C@H](C)C(=O)Nc1ccccc1.,CCC[NH+](Cc1cccc2cn[nH]c12)[C@H](C)C(=O)Nc1ccccc1,hydroxyl
11030,Please add a benzene ring to the molecule COc1ccc(-c2cc(C(=O)N3CCC[C@H]3c3cc(C)on3)no2)cc1.,COc1ccc(-c2cc(C(=O)N3CCC[C@H]3c3cc(C)on3)no2)cc1,benzene ring
52957,Please add a aldehyde to the molecule CC1(C)CSC[C@H](N[C@H]2CC[NH+](C3CC3)C2)C1.,CC1(C)CSC[C@H](N[C@H]2CC[NH+](C3CC3)C2)C1,aldehyde
167538,Add a amine to the molecule N#C/C(=C\c1ccco1)C(=O)Nc1cccc(C2SCCS2)c1.,N#C/C(=C\c1ccco1)C(=O)Nc1cccc(C2SCCS2)c1,amine
213959,Add a amide to the molecule CC(C)C[C@@H](C(=O)NCCc1ncnn1C)N1C(=O)[C@H]2CC=CC[C@@H]2C1=O.,CC(C)C[C@@H](C(=O)NCCc1ncnn1C)N1C(=O)[C@H]2CC=CC[C@@H]2C1=O,amide
196680,Add a nitro to the molecule O=C1CC[C@H](C(=O)N2CC[NH+](Cc3cccs3)CC2)CN1Cc1ccccn1.,O=C1CC[C@H](C(=O)N2CC[NH+](Cc3cccs3)CC2)CN1Cc1ccccn1,nitro
122502,Please add a carboxyl to the molecule COCc1nc(C)c(C(=O)Nc2ccc3c(c2)C(=O)NC3)s1.,COCc1nc(C)c(C(=O)Nc2ccc3c(c2)C(=O)NC3)s1,carboxyl
173308,Please add a hydroxyl to the molecule C/C(=N/NC(=O)CC#N)c1ccc2cc[nH]c2c1.,C/C(=N/NC(=O)CC#N)c1ccc2cc[nH]c2c1,hydroxyl
158241,Please add a benzene ring to the molecule C[C@H]1CCC[NH+](CCCC[NH2+][C@@H](C)c2nccs2)C1.,C[C@H]1CCC[NH+](CCCC[NH2+][C@@H](C)c2nccs2)C1,benzene ring
26949,Modify the molecule CCOc1ccc(N(CCC#N)C(=O)c2ccoc2C)cc1 by adding a halo.,CCOc1ccc(N(CCC#N)C(=O)c2ccoc2C)cc1,halo
81692,Add a hydroxyl to the molecule CC1(C)CC[NH+](Cc2cccc(C#N)c2)C1.,CC1(C)CC[NH+](Cc2cccc(C#N)c2)C1,hydroxyl
40731,Modify the molecule CC1=C(C#N)[C@@](NC(=O)c2cccc([N+](=O)[O-])c2)(C(F)(F)F)C([O-])=N1 by adding a hydroxyl.,CC1=C(C#N)[C@@](NC(=O)c2cccc([N+](=O)[O-])c2)(C(F)(F)F)C([O-])=N1,hydroxyl
81846,Add a nitro to the molecule CNC(=O)[C@H](C)CN(C)C(=O)Cc1ccc(-c2csc(C)n2)cc1.,CNC(=O)[C@H](C)CN(C)C(=O)Cc1ccc(-c2csc(C)n2)cc1,nitro
198318,Modify the molecule COc1ccc(OC)c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)c1 by adding a carboxyl.,COc1ccc(OC)c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)c1,carboxyl
184879,Modify the molecule O=C([O-])CNC(=O)CCCNC(=O)c1cccs1 by adding a benzene ring.,O=C([O-])CNC(=O)CCCNC(=O)c1cccs1,benzene ring
152986,Please add a benzene ring to the molecule COC(=O)[C@@H](c1ccccc1)N1C(=O)/C(=C/c2ccc(C(=O)[O-])cc2)SC1=S.,COC(=O)[C@@H](c1ccccc1)N1C(=O)/C(=C/c2ccc(C(=O)[O-])cc2)SC1=S,benzene ring
146946,Add a benzene ring to the molecule C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1.,C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1,benzene ring
138973,Please add a benzene ring to the molecule CCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)cc1.,CCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)cc1,benzene ring
72468,Please add a hydroxyl to the molecule CN1CCO[C@H](CNC2=[NH+][C@H](c3ccccc3)CS2)C1.,CN1CCO[C@H](CNC2=[NH+][C@H](c3ccccc3)CS2)C1,hydroxyl
224322,Please add a benzene ring to the molecule CCc1ccc(O[P@@](C)(=O)Nc2cc(Cl)ccc2Cl)cc1.,CCc1ccc(O[P@@](C)(=O)Nc2cc(Cl)ccc2Cl)cc1,benzene ring
245735,Please add a hydroxyl to the molecule O=C(C[n+]1ccc2ccccc2c1)c1cccc(Br)c1.,O=C(C[n+]1ccc2ccccc2c1)c1cccc(Br)c1,hydroxyl
44451,Modify the molecule COc1ccc(-c2cc(C(=O)N/N=C(\C)c3ccc([N+](=O)[O-])cc3)[nH]n2)c(OC)c1 by adding a benzene ring.,COc1ccc(-c2cc(C(=O)N/N=C(\C)c3ccc([N+](=O)[O-])cc3)[nH]n2)c(OC)c1,benzene ring
44287,Please add a amine to the molecule Cc1cccc(NC(=O)N2C[C@H](C)CC[C@@H]2C)c1C#N.,Cc1cccc(NC(=O)N2C[C@H](C)CC[C@@H]2C)c1C#N,amine
105860,Please add a benzene ring to the molecule Cc1cc([C@]2(C)NC(=O)N(CC(=O)c3ccc4c(c3)CCC4)C2=O)c(C)o1.,Cc1cc([C@]2(C)NC(=O)N(CC(=O)c3ccc4c(c3)CCC4)C2=O)c(C)o1,benzene ring
154369,Add a amine to the molecule O=C(NC1(c2ccc(Br)cc2)CCC1)C1CCC1.,O=C(NC1(c2ccc(Br)cc2)CCC1)C1CCC1,amine
135133,Modify the molecule Cc1ccc2c(c1)CCN2C(=O)CN1C(=O)c2ccc(C)cc2C1=O by adding a carboxyl.,Cc1ccc2c(c1)CCN2C(=O)CN1C(=O)c2ccc(C)cc2C1=O,carboxyl
68856,Modify the molecule CC(=O)N1CCC([NH2+][C@H]2C[C@@H](Cc3cc(CN4CCN(c5ccccc5)CC4)on3)C2(C)C)CC1 by adding a benzene ring.,CC(=O)N1CCC([NH2+][C@H]2C[C@@H](Cc3cc(CN4CCN(c5ccccc5)CC4)on3)C2(C)C)CC1,benzene ring
7674,Modify the molecule CN(CC(=O)N1CCOCC1)C(=O)c1cccc(Cl)c1 by adding a benzene ring.,CN(CC(=O)N1CCOCC1)C(=O)c1cccc(Cl)c1,benzene ring
131411,Please add a amide to the molecule Cc1ccccc1-c1noc([C@H](C)SCC2(CO)COC2)n1.,Cc1ccccc1-c1noc([C@H](C)SCC2(CO)COC2)n1,amide
123304,Add a amine to the molecule COc1ccc(OCCSC2=N[C@H]3CCCC[C@@H]3N2)cc1.,COc1ccc(OCCSC2=N[C@H]3CCCC[C@@H]3N2)cc1,amine
244102,Please add a benzene ring to the molecule O=C(Nc1ccc(OS(=O)(=O)c2ccccc2Br)cc1)C1CC1.,O=C(Nc1ccc(OS(=O)(=O)c2ccccc2Br)cc1)C1CC1,benzene ring
139985,Modify the molecule CC1(C)C[C@@H]([NH2+][C@H](CCC#N)c2ccccc2)c2ccc(F)cc2O1 by adding a benzene ring.,CC1(C)C[C@@H]([NH2+][C@H](CCC#N)c2ccccc2)c2ccc(F)cc2O1,benzene ring
243582,Please add a benzene ring to the molecule CC[C@@H](NC(=O)[C@@H](C)NC(C)=O)c1ccc(Cl)cc1.,CC[C@@H](NC(=O)[C@@H](C)NC(C)=O)c1ccc(Cl)cc1,benzene ring
66667,Modify the molecule Cc1ccccc1C(=O)Nc1ccc(C(=O)NNC(=O)/C=C/c2cccs2)cc1 by adding a nitro.,Cc1ccccc1C(=O)Nc1ccc(C(=O)NNC(=O)/C=C/c2cccs2)cc1,nitro
23320,Modify the molecule N#C/C(=C/c1cc(Br)cs1)c1nc(-c2ccc(C#N)cc2)cs1 by adding a halo.,N#C/C(=C/c1cc(Br)cs1)c1nc(-c2ccc(C#N)cc2)cs1,halo
166941,Add a hydroxyl to the molecule COc1ccc([C@H](C)[NH2+][C@H](C)C(=O)Nc2cccc(C)c2C)cc1OC.,COc1ccc([C@H](C)[NH2+][C@H](C)C(=O)Nc2cccc(C)c2C)cc1OC,hydroxyl
114137,Add a amine to the molecule C[C@H]([NH3+])c1ccc(S[C@H](C)CCO)cc1.,C[C@H]([NH3+])c1ccc(S[C@H](C)CCO)cc1,amine
52916,Add a hydroxyl to the molecule Cc1cc(/C=N/NC(N)=S)c(C)n1-c1ccc(Cl)c(Cl)c1.,Cc1cc(/C=N/NC(N)=S)c(C)n1-c1ccc(Cl)c(Cl)c1,hydroxyl
144473,Add a benzene ring to the molecule COCCOCc1cccc(NC(=O)N[C@H]2CCCC[C@H]2C)c1.,COCCOCc1cccc(NC(=O)N[C@H]2CCCC[C@H]2C)c1,benzene ring
164332,Add a amine to the molecule CC[NH+]1CCN(c2ccccc2NC(=O)CSc2nnc(-c3ccccc3F)o2)CC1.,CC[NH+]1CCN(c2ccccc2NC(=O)CSc2nnc(-c3ccccc3F)o2)CC1,amine
173488,Please add a benzene ring to the molecule CCCCn1nnnc1CSc1cc(N)ccc1C.,CCCCn1nnnc1CSc1cc(N)ccc1C,benzene ring
752,Please add a halo to the molecule CCNS(=O)(=O)[C@@H]1CC[NH+](C[C@@H]2CCCc3ccccc32)C1.,CCNS(=O)(=O)[C@@H]1CC[NH+](C[C@@H]2CCCc3ccccc32)C1,halo
204565,Add a halo to the molecule COc1ccc(CN2CCO[C@@]3(CCc4ccccc43)C2)s1.,COc1ccc(CN2CCO[C@@]3(CCc4ccccc43)C2)s1,halo
248006,Add a benzene ring to the molecule COC[C@@H](O)CNC(=O)N[C@H](C)c1ccc(-c2ccc(Cl)cc2)s1.,COC[C@@H](O)CNC(=O)N[C@H](C)c1ccc(-c2ccc(Cl)cc2)s1,benzene ring
125204,Please add a benzene ring to the molecule N#C[C@@H]1CN(c2ccc3c(c2)NC(=O)[C@@H]3O)CCO1.,N#C[C@@H]1CN(c2ccc3c(c2)NC(=O)[C@@H]3O)CCO1,benzene ring
74042,Add a halo to the molecule COC(=O)c1cc(NC(=O)Nc2ccc(C)cc2)cc(C(=O)OC)c1.,COC(=O)c1cc(NC(=O)Nc2ccc(C)cc2)cc(C(=O)OC)c1,halo
151556,Add a aldehyde to the molecule C[NH+](C)[C@H]1CC[C@@H](NC(=O)N2CCC(N3CCCC3=O)CC2)C1.,C[NH+](C)[C@H]1CC[C@@H](NC(=O)N2CCC(N3CCCC3=O)CC2)C1,aldehyde
116268,Modify the molecule CCSC[C@H](C)N(C)C(=O)N[C@H]1CCC[C@H](C)C1 by adding a carboxyl.,CCSC[C@H](C)N(C)C(=O)N[C@H]1CCC[C@H](C)C1,carboxyl
215272,Please add a amide to the molecule O=C(Cn1cnc2cc(F)c(F)cc21)NC1CC1.,O=C(Cn1cnc2cc(F)c(F)cc21)NC1CC1,amide
103148,Modify the molecule CCC1(CNC(=O)N[C@@H](C)Cc2c(C)noc2C)CCC1 by adding a benzene ring.,CCC1(CNC(=O)N[C@@H](C)Cc2c(C)noc2C)CCC1,benzene ring
27979,Modify the molecule O=C(NCc1ccccc1Cl)[C@H]1CCCN(c2ncnc3[nH]cnc23)C1 by adding a nitrile.,O=C(NCc1ccccc1Cl)[C@H]1CCCN(c2ncnc3[nH]cnc23)C1,nitrile
76886,Please add a benzene ring to the molecule CCc1ccccc1NC(=O)[C@H]1CCC(=O)N(c2ccc(OC)cc2)[C@@H]1c1ccc(OC)cc1.,CCc1ccccc1NC(=O)[C@H]1CCC(=O)N(c2ccc(OC)cc2)[C@@H]1c1ccc(OC)cc1,benzene ring
55586,Modify the molecule CCN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)[C@@H](C)Oc1cccc(C=O)c1 by adding a hydroxyl.,CCN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)[C@@H](C)Oc1cccc(C=O)c1,hydroxyl
150512,Please add a benzene ring to the molecule O=C1C[C@@H](C(=O)N2CCCCC[C@H]2c2ccncc2)CN1CC1CC1.,O=C1C[C@@H](C(=O)N2CCCCC[C@H]2c2ccncc2)CN1CC1CC1,benzene ring
76124,Modify the molecule Cc1nccn1Cc1cccc(CNC(=O)[C@H]2C[C@@H]3C=C[C@H]2C3)c1 by adding a aldehyde.,Cc1nccn1Cc1cccc(CNC(=O)[C@H]2C[C@@H]3C=C[C@H]2C3)c1,aldehyde
107066,Add a amine to the molecule Cc1ccc(Cl)cc1NCCNc1ccccc1.,Cc1ccc(Cl)cc1NCCNc1ccccc1,amine
210902,Add a hydroxyl to the molecule CCc1nnc2n1N[C@@H](c1ccc(F)cc1)[C@@H](C(=O)Nc1ccc(C)c(C)c1)S2.,CCc1nnc2n1N[C@@H](c1ccc(F)cc1)[C@@H](C(=O)Nc1ccc(C)c(C)c1)S2,hydroxyl
146576,Modify the molecule ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1 by adding a benzene ring.,ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1,benzene ring
129646,Modify the molecule Cc1ccc(NCc2ccnc(-n3ccnc3)c2)c([N+](=O)[O-])c1 by adding a aldehyde.,Cc1ccc(NCc2ccnc(-n3ccnc3)c2)c([N+](=O)[O-])c1,aldehyde
58412,Add a hydroxyl to the molecule C[C@@H](N[C@@H]1CSCc2ccccc21)[C@@H]1COc2ccccc21.,C[C@@H](N[C@@H]1CSCc2ccccc21)[C@@H]1COc2ccccc21,hydroxyl
188570,Add a amide to the molecule COc1cccc(N2CCN(C(=O)[C@H]3C=C(c4ccc(C)cc4C)N=N3)CC2)c1.,COc1cccc(N2CCN(C(=O)[C@H]3C=C(c4ccc(C)cc4C)N=N3)CC2)c1,amide
198412,Modify the molecule Cc1cnc2c(S(=O)(=O)N3CCC(C(=O)NCC(C)C)CC3)cccc2c1 by adding a nitrile.,Cc1cnc2c(S(=O)(=O)N3CCC(C(=O)NCC(C)C)CC3)cccc2c1,nitrile
98541,Modify the molecule CCC[C@@H]1CN(C(=O)[C@H](C)OCCOC)CCO1 by adding a hydroxyl.,CCC[C@@H]1CN(C(=O)[C@H](C)OCCOC)CCO1,hydroxyl
207285,Modify the molecule COC[C@@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C(C)C)C(N)=O by adding a hydroxyl.,COC[C@@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C(C)C)C(N)=O,hydroxyl
203417,Please add a benzene ring to the molecule C[C@H](C(=O)Nc1nc2ccc(F)cn2n1)c1ccc(Cl)s1.,C[C@H](C(=O)Nc1nc2ccc(F)cn2n1)c1ccc(Cl)s1,benzene ring
91610,Modify the molecule Cc1c(C[NH+]2CC[C@H](CNS(=O)(=O)C3CC3)C2)oc2ccccc12 by adding a nitro.,Cc1c(C[NH+]2CC[C@H](CNS(=O)(=O)C3CC3)C2)oc2ccccc12,nitro
126031,Modify the molecule CCC[NH2+]C/C(=C\c1cc(Cl)cs1)CC by adding a halo.,CCC[NH2+]C/C(=C\c1cc(Cl)cs1)CC,halo
154594,Add a benzene ring to the molecule COc1ccc(-c2nc(C(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cs2)cc1OC.,COc1ccc(-c2nc(C(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cs2)cc1OC,benzene ring
153429,Please add a aldehyde to the molecule COc1cccc(-c2cc3n(C)c(C)c(CCC(=O)NCc4ccc5c(c4)OCO5)c(=O)n3n2)c1.,COc1cccc(-c2cc3n(C)c(C)c(CCC(=O)NCc4ccc5c(c4)OCO5)c(=O)n3n2)c1,aldehyde
234759,Add a hydroxyl to the molecule C[C@H]1Cc2c(NC(=O)Cc3ccc(-c4ccccc4)cc3)nn(C)c2NC1=O.,C[C@H]1Cc2c(NC(=O)Cc3ccc(-c4ccccc4)cc3)nn(C)c2NC1=O,hydroxyl
184143,Please add a amide to the molecule CC1=C2C(CSc3c(Cl)cccc3Cl)=CC(=O)N=C2S[C@H]1C(=O)[O-].,CC1=C2C(CSc3c(Cl)cccc3Cl)=CC(=O)N=C2S[C@H]1C(=O)[O-],amide
161588,Modify the molecule Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F by adding a benzene ring.,Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F,benzene ring
111911,Add a hydroxyl to the molecule CC(C)CC[C@@H](C)NC(=O)Nc1ccccn1.,CC(C)CC[C@@H](C)NC(=O)Nc1ccccn1,hydroxyl
21379,Add a nitrile to the molecule O=C(OCc1nncn1C1CC1)[C@H]1C[C@@H]1c1cccc2ccccc12.,O=C(OCc1nncn1C1CC1)[C@H]1C[C@@H]1c1cccc2ccccc12,nitrile
168738,Please add a halo to the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2cccc(N3CCCC3=O)c2)C1.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2cccc(N3CCCC3=O)c2)C1,halo
19683,Please add a benzene ring to the molecule COc1ccc(F)cc1C[NH+]1CCN(CC(=O)Nc2sccc2C#N)CC1.,COc1ccc(F)cc1C[NH+]1CCN(CC(=O)Nc2sccc2C#N)CC1,benzene ring
213122,Add a hydroxyl to the molecule C[C@@H]1C[NH+](CC(=O)c2ccccc2F)C[C@@H]1C.,C[C@@H]1C[NH+](CC(=O)c2ccccc2F)C[C@@H]1C,hydroxyl
38003,Modify the molecule Cc1ccc(Cl)cc1N(C)C(=O)c1nn(C)c2c1COc1ccccc1-2 by adding a nitro.,Cc1ccc(Cl)cc1N(C)C(=O)c1nn(C)c2c1COc1ccccc1-2,nitro
124240,Modify the molecule CCNC(=O)c1ccc(Cl)cc1NC(=O)CC(C)(C)C by adding a benzene ring.,CCNC(=O)c1ccc(Cl)cc1NC(=O)CC(C)(C)C,benzene ring
218982,Modify the molecule Cc1noc([C@H](C)OC(=O)Cc2c(F)cccc2F)n1 by adding a amide.,Cc1noc([C@H](C)OC(=O)Cc2c(F)cccc2F)n1,amide
154668,Add a amine to the molecule Cc1cccc(OCC(=O)Nc2scnc2C)c1.,Cc1cccc(OCC(=O)Nc2scnc2C)c1,amine
73973,Add a carboxyl to the molecule Nc1ccccc1-c1nc(-c2ccco2)no1.,Nc1ccccc1-c1nc(-c2ccco2)no1,carboxyl
18197,Modify the molecule Cc1ccc2[nH+]c(CN3CCN(S(=O)(=O)c4cc(C)sc4C)CC3)cn2c1 by adding a halo.,Cc1ccc2[nH+]c(CN3CCN(S(=O)(=O)c4cc(C)sc4C)CC3)cn2c1,halo
76795,Add a aldehyde to the molecule COc1ccc(C(=O)N2CC[NH+](Cc3nc(-c4ccc(C)cc4)oc3C)CC2)cc1OC.,COc1ccc(C(=O)N2CC[NH+](Cc3nc(-c4ccc(C)cc4)oc3C)CC2)cc1OC,aldehyde
184411,Modify the molecule COc1ccc(NC(=O)CSCC(=O)N(C)[C@H]2CCC[C@@H](C)C2)cc1 by adding a halo.,COc1ccc(NC(=O)CSCC(=O)N(C)[C@H]2CCC[C@@H](C)C2)cc1,halo
204409,Please add a aldehyde to the molecule CCCCC(=O)N1CCC([NH+]2CCC[C@@H](C(=O)NCc3ccccn3)C2)CC1.,CCCCC(=O)N1CCC([NH+]2CCC[C@@H](C(=O)NCc3ccccn3)C2)CC1,aldehyde
131157,Please add a amine to the molecule CN(CCOc1ccccc1F)c1ccc([N+](=O)[O-])cc1C(N)=O.,CN(CCOc1ccccc1F)c1ccc([N+](=O)[O-])cc1C(N)=O,amine
145600,Modify the molecule O=S(=O)(c1cc(Cl)ccc1Cl)N1CCC[C@@H](c2ncc[nH]2)C1 by adding a benzene ring.,O=S(=O)(c1cc(Cl)ccc1Cl)N1CCC[C@@H](c2ncc[nH]2)C1,benzene ring
2402,Add a aldehyde to the molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1.,CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1,aldehyde
148783,Please add a halo to the molecule C[C@H]1CCCCN1C(=O)C(=O)NCC[NH3+].,C[C@H]1CCCCN1C(=O)C(=O)NCC[NH3+],halo
164730,Please add a benzene ring to the molecule C=CCN(CC=C)C(=O)Nc1ccccc1Cl.,C=CCN(CC=C)C(=O)Nc1ccccc1Cl,benzene ring
214720,Modify the molecule Cc1ccc(CSc2nnc(N/N=C/c3ccc(Cl)cc3)[nH]2)cc1 by adding a nitro.,Cc1ccc(CSc2nnc(N/N=C/c3ccc(Cl)cc3)[nH]2)cc1,nitro
204820,Please add a amide to the molecule C/C(=N\NC(=O)C[NH+]1CCN(c2ccccc2)CC1)c1ccc(F)cc1.,C/C(=N\NC(=O)C[NH+]1CCN(c2ccccc2)CC1)c1ccc(F)cc1,amide
114120,Add a hydroxyl to the molecule COc1cccc(NC(=O)CN2CCN(C(=O)c3ccc(C)cc3)CC2)c1.,COc1cccc(NC(=O)CN2CCN(C(=O)c3ccc(C)cc3)CC2)c1,hydroxyl
192926,Modify the molecule O=C(c1cnn(Cc2ccccc2)c1)N1CCN(Cc2ccccc2)CC1 by adding a hydroxyl.,O=C(c1cnn(Cc2ccccc2)c1)N1CCN(Cc2ccccc2)CC1,hydroxyl
233677,Please add a amide to the molecule CC[C@H]1CCCC[C@@H]1OC(=O)[C@@H]1CC[C@H](C[NH3+])O1.,CC[C@H]1CCCC[C@@H]1OC(=O)[C@@H]1CC[C@H](C[NH3+])O1,amide
196951,Add a amine to the molecule Cc1ccc(N(CCC#N)C(=O)CN2CC[NH+](C(C)C)CC2)cc1C.,Cc1ccc(N(CCC#N)C(=O)CN2CC[NH+](C(C)C)CC2)cc1C,amine
4553,Modify the molecule c1cnn(C[C@H]2CN(CCCOc3ccc4c(c3)OCO4)CCO2)c1 by adding a amine.,c1cnn(C[C@H]2CN(CCCOc3ccc4c(c3)OCO4)CCO2)c1,amine
75719,Please add a amine to the molecule COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1.,COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1,amine
63701,Modify the molecule COc1ccc2oc([C@H](C)NC(=O)NC[C@H](C)C[C@@H](C)O)c(C)c2c1 by adding a hydroxyl.,COc1ccc2oc([C@H](C)NC(=O)NC[C@H](C)C[C@@H](C)O)c(C)c2c1,hydroxyl
45163,Modify the molecule C[C@H]1C[C@H]2CCCC[C@@H]2N1C(=O)c1ccccn1 by adding a aldehyde.,C[C@H]1C[C@H]2CCCC[C@@H]2N1C(=O)c1ccccn1,aldehyde
155459,Add a carboxyl to the molecule COc1ccccc1C(=O)Nc1ccc(F)c(S(=O)(=O)NC2CC2)c1.,COc1ccccc1C(=O)Nc1ccc(F)c(S(=O)(=O)NC2CC2)c1,carboxyl
173449,Please add a carboxyl to the molecule CCOC(CNC(=O)[C@@H]1COc2ccccc2O1)OCC.,CCOC(CNC(=O)[C@@H]1COc2ccccc2O1)OCC,carboxyl
29934,Please add a thiol to the molecule C#CCOc1ccc([C@@H]2CC(=O)Nc3c2c(=O)nc(SCc2ccc(Cl)cc2)n3C)cc1OC.,C#CCOc1ccc([C@@H]2CC(=O)Nc3c2c(=O)nc(SCc2ccc(Cl)cc2)n3C)cc1OC,thiol
225968,Modify the molecule CCC[C@H]1[C@H](C)CCCN1C(=O)CN1C(=O)NC(=O)C1(C)C by adding a hydroxyl.,CCC[C@H]1[C@H](C)CCCN1C(=O)CN1C(=O)NC(=O)C1(C)C,hydroxyl
223242,Modify the molecule Cc1ccc(OC(=O)c2cccc(N3NC(=O)[C@@H]4CC=CC[C@H]4C3=O)c2)cc1C by adding a nitro.,Cc1ccc(OC(=O)c2cccc(N3NC(=O)[C@@H]4CC=CC[C@H]4C3=O)c2)cc1C,nitro
86659,Please add a aldehyde to the molecule Cc1nc(N)nc(COc2ccccc2)n1.,Cc1nc(N)nc(COc2ccccc2)n1,aldehyde
132595,Add a benzene ring to the molecule C[C@H]1OCC[C@H]1[C@H]([NH3+])c1ccc(-c2ccccc2)cc1.,C[C@H]1OCC[C@H]1[C@H]([NH3+])c1ccc(-c2ccccc2)cc1,benzene ring
118273,Modify the molecule CNC(=O)c1ccc(Nc2ncnc3sc(-c4ccccc4)c(C)c23)cc1 by adding a nitro.,CNC(=O)c1ccc(Nc2ncnc3sc(-c4ccccc4)c(C)c23)cc1,nitro
104760,Please add a nitro to the molecule CC(C)[C@@H](CNC(=O)Nc1ccccc1F)N1CC[NH+](C)CC1.,CC(C)[C@@H](CNC(=O)Nc1ccccc1F)N1CC[NH+](C)CC1,nitro
246887,Please add a aldehyde to the molecule CC(C)n1nnnc1COc1ccc(C(=O)N(C)Cc2cccc(F)c2)cc1.,CC(C)n1nnnc1COc1ccc(C(=O)N(C)Cc2cccc(F)c2)cc1,aldehyde
210076,Modify the molecule C/C=C/C=C/C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1 by adding a hydroxyl.,C/C=C/C=C/C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1,hydroxyl
70779,Please add a aldehyde to the molecule CCc1ccccc1S(=O)(=O)NCc1ccc2c(c1)N(C(=O)c1ccccc1)CC2.,CCc1ccccc1S(=O)(=O)NCc1ccc2c(c1)N(C(=O)c1ccccc1)CC2,aldehyde
208721,Modify the molecule CO[C@]1(C)C[C@@H]([NH+](C)CCC(=O)N(C)CCC#N)C1(C)C by adding a carboxyl.,CO[C@]1(C)C[C@@H]([NH+](C)CCC(=O)N(C)CCC#N)C1(C)C,carboxyl
214154,Add a amide to the molecule Cn1cccc1[C@@H]1CCCCCN1C(=O)[C@@H]1C[C@@H]1c1ccccc1Cl.,Cn1cccc1[C@@H]1CCCCCN1C(=O)[C@@H]1C[C@@H]1c1ccccc1Cl,amide
14531,Modify the molecule CN(C(=O)CCN1CCCC1=O)C1CCN(c2cccc(F)c2)CC1 by adding a carboxyl.,CN(C(=O)CCN1CCCC1=O)C1CCN(c2cccc(F)c2)CC1,carboxyl
206130,Please add a aldehyde to the molecule COc1ccc(NC(C)=O)cc1NCc1noc(-c2cccs2)n1.,COc1ccc(NC(C)=O)cc1NCc1noc(-c2cccs2)n1,aldehyde
86681,Modify the molecule CCN(CCC(=O)OC)C(=O)c1csc2c1CCCC2 by adding a aldehyde.,CCN(CCC(=O)OC)C(=O)c1csc2c1CCCC2,aldehyde
111248,Add a hydroxyl to the molecule COc1cccc(O[C@H](C)CNC(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1.,COc1cccc(O[C@H](C)CNC(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1,hydroxyl
191007,Add a nitrile to the molecule C[NH2+][C@@H]1CCCN(C(=O)c2cc(C)c(Br)s2)C1.,C[NH2+][C@@H]1CCCN(C(=O)c2cc(C)c(Br)s2)C1,nitrile
201214,Modify the molecule C[NH+](Cc1nc(C2CC2)no1)[C@H]1CCN(c2ccccc2Cl)C1=O by adding a amide.,C[NH+](Cc1nc(C2CC2)no1)[C@H]1CCN(c2ccccc2Cl)C1=O,amide
135841,Please add a hydroxyl to the molecule COc1cc(F)cc(CNC(=O)N[C@@H](CO)Cc2c[nH]c3ccccc23)c1.,COc1cc(F)cc(CNC(=O)N[C@@H](CO)Cc2c[nH]c3ccccc23)c1,hydroxyl
136804,Please add a carboxyl to the molecule COc1ccc(Cl)cc1C(=O)n1cnc2ccccc21.,COc1ccc(Cl)cc1C(=O)n1cnc2ccccc21,carboxyl
97509,Modify the molecule CC[C@@H](C#N)Oc1cccc(CNC(=O)N(C)C[C@H](C)O)c1 by adding a nitro.,CC[C@@H](C#N)Oc1cccc(CNC(=O)N(C)C[C@H](C)O)c1,nitro
156290,Add a amine to the molecule CCOC(=O)C1CC[NH+](Cc2nnn(-c3cc(F)cc(F)c3)c2-c2ccncc2)CC1.,CCOC(=O)C1CC[NH+](Cc2nnn(-c3cc(F)cc(F)c3)c2-c2ccncc2)CC1,amine
197356,Add a benzene ring to the molecule Cc1cc(/C=N\NC(=O)C(=O)Nc2cccc(C(F)(F)F)c2)c(C)n1-c1ccccc1Cl.,Cc1cc(/C=N\NC(=O)C(=O)Nc2cccc(C(F)(F)F)c2)c(C)n1-c1ccccc1Cl,benzene ring
204907,Please add a hydroxyl to the molecule C[C@H](NCc1ncc(-c2ccccc2)s1)C(=O)N1CCCC[C@H]1C.,C[C@H](NCc1ncc(-c2ccccc2)s1)C(=O)N1CCCC[C@H]1C,hydroxyl
208730,Modify the molecule Cc1[nH]c(=O)c(C#N)c(C)c1CCC(=O)N1CCO[C@@H]2CCCC[C@H]21 by adding a hydroxyl.,Cc1[nH]c(=O)c(C#N)c(C)c1CCC(=O)N1CCO[C@@H]2CCCC[C@H]21,hydroxyl
9658,Please add a hydroxyl to the molecule CCCCCN(C(=O)N[C@H](C)c1ncc(C)s1)C(C)C.,CCCCCN(C(=O)N[C@H](C)c1ncc(C)s1)C(C)C,hydroxyl
67070,Please add a amide to the molecule C[NH+]1CCC(NC(=O)CCc2ccccc2)CC1.,C[NH+]1CCC(NC(=O)CCc2ccccc2)CC1,amide
234718,Modify the molecule O=S(=O)(NCCS(=O)(=O)N1CCc2ccccc21)c1ccc(F)cc1F by adding a hydroxyl.,O=S(=O)(NCCS(=O)(=O)N1CCc2ccccc21)c1ccc(F)cc1F,hydroxyl
70949,Add a carboxyl to the molecule Cc1ccsc1C[NH+]1CCC(C(=O)N2C[C@H](C)O[C@H](C)C2)CC1.,Cc1ccsc1C[NH+]1CCC(C(=O)N2C[C@H](C)O[C@H](C)C2)CC1,carboxyl
152569,Modify the molecule CC(=O)N1CCc2cc(NCc3csc4ccccc34)ccc21 by adding a benzene ring.,CC(=O)N1CCc2cc(NCc3csc4ccccc34)ccc21,benzene ring
202698,Please add a benzene ring to the molecule C(=N\Nc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1)\c1cccnc1.,C(=N\Nc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1)\c1cccnc1,benzene ring
204435,Modify the molecule O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2nnc3n2CCCCC3)cc1 by adding a benzene ring.,O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2nnc3n2CCCCC3)cc1,benzene ring
148593,Add a benzene ring to the molecule Cc1ccc(NC(=O)COc2cc(C)nc(N3CCCCC3)n2)cc1.,Cc1ccc(NC(=O)COc2cc(C)nc(N3CCCCC3)n2)cc1,benzene ring
157182,Add a nitro to the molecule Cc1cc(C)c2sc(NC(=O)c3cc4ccccc4o3)nc2n1.,Cc1cc(C)c2sc(NC(=O)c3cc4ccccc4o3)nc2n1,nitro
12579,Modify the molecule C[C@H]1CN[C@H](c2cccc(C3CC3)c2)S1 by adding a aldehyde.,C[C@H]1CN[C@H](c2cccc(C3CC3)c2)S1,aldehyde
247148,Add a hydroxyl to the molecule Cc1cc(O[C@H](C)C(=O)N(Cc2ccc([C@@H]3C[C@@H]3C)o2)[C@@H]2CCS(=O)(=O)C2)cc(C)c1Cl.,Cc1cc(O[C@H](C)C(=O)N(Cc2ccc([C@@H]3C[C@@H]3C)o2)[C@@H]2CCS(=O)(=O)C2)cc(C)c1Cl,hydroxyl
94638,Please add a aldehyde to the molecule C=C1C(=O)[C@]2(C)CC[C@H]1C2(C)C.,C=C1C(=O)[C@]2(C)CC[C@H]1C2(C)C,aldehyde
156883,Modify the molecule COc1ccc2nc(NC(=O)c3ccc4nc(C)sc4c3)sc2c1 by adding a thiol.,COc1ccc2nc(NC(=O)c3ccc4nc(C)sc4c3)sc2c1,thiol
124150,Modify the molecule CN(C)c1ccc(CNC(=O)N2CCC(OC[C@@H]3CCCO3)CC2)cc1F by adding a carboxyl.,CN(C)c1ccc(CNC(=O)N2CCC(OC[C@@H]3CCCO3)CC2)cc1F,carboxyl
123175,Modify the molecule Cc1ncc(-c2ccncc2)c([C@H]2CCCN(C(=O)c3ccco3)C2)n1 by adding a carboxyl.,Cc1ncc(-c2ccncc2)c([C@H]2CCCN(C(=O)c3ccco3)C2)n1,carboxyl
232684,Add a benzene ring to the molecule CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1.,CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1,benzene ring
199095,Modify the molecule [NH3+]CCCCC/C(=N/O)c1ccccn1 by adding a benzene ring.,[NH3+]CCCCC/C(=N/O)c1ccccn1,benzene ring
202099,Add a aldehyde to the molecule CC(=O)Nc1ccc(OC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)cc1.,CC(=O)Nc1ccc(OC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)cc1,aldehyde
55728,Add a hydroxyl to the molecule C[C@H](C(=O)NN)[C@@H](C)n1ccc([N+](=O)[O-])n1.,C[C@H](C(=O)NN)[C@@H](C)n1ccc([N+](=O)[O-])n1,hydroxyl
138548,Modify the molecule COC(=O)c1ccc(C)c(NC(=O)[C@H](C)[NH2+][C@@H](C)c2ccc(C)cc2)c1 by adding a hydroxyl.,COC(=O)c1ccc(C)c(NC(=O)[C@H](C)[NH2+][C@@H](C)c2ccc(C)cc2)c1,hydroxyl
65712,Add a benzene ring to the molecule Cc1sc2nc(S[C@@H](C)C(N)=O)n(C)c(=O)c2c1C.,Cc1sc2nc(S[C@@H](C)C(N)=O)n(C)c(=O)c2c1C,benzene ring
221864,Please add a nitro to the molecule Cn1c(=O)oc2cc(NC(=O)NCCC(=O)NC3CCCCC3)ccc21.,Cn1c(=O)oc2cc(NC(=O)NCCC(=O)NC3CCCCC3)ccc21,nitro
48719,Add a nitro to the molecule C[C@H](OC(=O)[C@@H]1C[C@@H]1C)c1cccc(C#N)c1.,C[C@H](OC(=O)[C@@H]1C[C@@H]1C)c1cccc(C#N)c1,nitro
10988,Modify the molecule Cc1cccc(NC(=S)N(Cc2cccnc2)C2CC2)c1Cl by adding a benzene ring.,Cc1cccc(NC(=S)N(Cc2cccnc2)C2CC2)c1Cl,benzene ring
163972,Add a benzene ring to the molecule COc1cccc(C[NH3+])c1O[C@H]1CCC[C@H](S(C)(=O)=O)C1.,COc1cccc(C[NH3+])c1O[C@H]1CCC[C@H](S(C)(=O)=O)C1,benzene ring
153513,Please add a hydroxyl to the molecule CCCC(=O)C(=O)N1CCc2nnc(CCc3ccccc3)n2CC1.,CCCC(=O)C(=O)N1CCc2nnc(CCc3ccccc3)n2CC1,hydroxyl
91229,Please add a amide to the molecule CC(=O)NCCNC(=O)N[C@@H]1CCCC[C@@H]1C(C)(C)C.,CC(=O)NCCNC(=O)N[C@@H]1CCCC[C@@H]1C(C)(C)C,amide
35331,Add a amide to the molecule CCn1nc(CC(C)C)cc1C(=O)Nn1cnnc1.,CCn1nc(CC(C)C)cc1C(=O)Nn1cnnc1,amide
246998,Modify the molecule COCCn1nc(C)c(NC(=O)c2cc(SC)ccc2C)c1C by adding a benzene ring.,COCCn1nc(C)c(NC(=O)c2cc(SC)ccc2C)c1C,benzene ring
217429,Add a hydroxyl to the molecule Cc1cc(C)n(-c2ccc(C(=O)O[C@@H](C)C(=O)Nc3cc(C)on3)cc2)n1.,Cc1cc(C)n(-c2ccc(C(=O)O[C@@H](C)C(=O)Nc3cc(C)on3)cc2)n1,hydroxyl
115658,Modify the molecule c1ccc(-c2ncn(Cc3ccc4c(c3)OCCCO4)c2[C@H]2CCOC2)cc1 by adding a amine.,c1ccc(-c2ncn(Cc3ccc4c(c3)OCCCO4)c2[C@H]2CCOC2)cc1,amine
95035,Modify the molecule CCn1nc(C)c(CNC(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C by adding a hydroxyl.,CCn1nc(C)c(CNC(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C,hydroxyl
245076,Add a amine to the molecule Cc1cc(C(=O)N2CCC[C@H]2C(=O)[O-])c2c(C)noc2n1.,Cc1cc(C(=O)N2CCC[C@H]2C(=O)[O-])c2c(C)noc2n1,amine
226469,Add a nitro to the molecule O=C(C[S@@](=O)CCN1C(=O)c2ccccc2C1=O)Nc1cccc(F)c1.,O=C(C[S@@](=O)CCN1C(=O)c2ccccc2C1=O)Nc1cccc(F)c1,nitro
121841,Modify the molecule CC(C)[NH+](CC[NH+]1CCCCC1)C[C@@H](C)O by adding a amine.,CC(C)[NH+](CC[NH+]1CCCCC1)C[C@@H](C)O,amine
148787,Modify the molecule CN1CCO[C@H]([C@H]([NH3+])Cc2cc(Br)ccc2F)C1 by adding a amide.,CN1CCO[C@H]([C@H]([NH3+])Cc2cc(Br)ccc2F)C1,amide
231733,Modify the molecule CC(C)n1cc2cc(NC(=O)C(=O)N[C@@H]3CCC[C@@H]([NH+](C)C)C3)ccc2n1 by adding a benzene ring.,CC(C)n1cc2cc(NC(=O)C(=O)N[C@@H]3CCC[C@@H]([NH+](C)C)C3)ccc2n1,benzene ring
228887,Add a hydroxyl to the molecule O=C(Nc1cccc(Cl)c1)N(CCCN1CCOCC1)Cc1cccc(F)c1.,O=C(Nc1cccc(Cl)c1)N(CCCN1CCOCC1)Cc1cccc(F)c1,hydroxyl
76253,Add a aldehyde to the molecule Cc1ccc(NC(=O)C[C@H](C)[NH2+]CCc2ccncc2C)cc1Cl.,Cc1ccc(NC(=O)C[C@H](C)[NH2+]CCc2ccncc2C)cc1Cl,aldehyde
86130,Please add a benzene ring to the molecule N#C[C@@H]1CN(C(=O)c2cccc(C(F)(F)F)c2N)CCO1.,N#C[C@@H]1CN(C(=O)c2cccc(C(F)(F)F)c2N)CCO1,benzene ring
21753,Add a amide to the molecule CCN(CCO)C(=O)Nc1nc(C)cs1.,CCN(CCO)C(=O)Nc1nc(C)cs1,amide
228006,Add a nitro to the molecule CCS(=O)(=O)NCCNC(=O)Cc1c(F)cccc1F.,CCS(=O)(=O)NCCNC(=O)Cc1c(F)cccc1F,nitro
210362,Add a aldehyde to the molecule C[C@H]1Cc2ccccc2N1C(=O)[C@H]1CCCN(S(C)(=O)=O)C1.,C[C@H]1Cc2ccccc2N1C(=O)[C@H]1CCCN(S(C)(=O)=O)C1,aldehyde
68746,Add a halo to the molecule O=C(NCc1ccc(Cl)nc1)[C@@H]1CC(=O)N(CC(F)(F)F)C1.,O=C(NCc1ccc(Cl)nc1)[C@@H]1CC(=O)N(CC(F)(F)F)C1,halo
80206,Modify the molecule CSc1cccc(Nc2c(C#N)cnc3ccc(Cl)cc23)c1 by adding a halo.,CSc1cccc(Nc2c(C#N)cnc3ccc(Cl)cc23)c1,halo
7640,Add a halo to the molecule Cc1ccc(-n2nc(C)cc2NC(=O)CCc2ccc3c(c2)OCO3)cc1.,Cc1ccc(-n2nc(C)cc2NC(=O)CCc2ccc3c(c2)OCO3)cc1,halo
238571,Modify the molecule CSc1ccc(C)c(C(=O)Nc2n[nH]c3ccc([N+](=O)[O-])cc23)c1 by adding a amine.,CSc1ccc(C)c(C(=O)Nc2n[nH]c3ccc([N+](=O)[O-])cc23)c1,amine
200865,Add a halo to the molecule C[C@@H]1C[NH+]([C@@H](C)C[C@@H](C)O)C[C@H]1C.,C[C@@H]1C[NH+]([C@@H](C)C[C@@H](C)O)C[C@H]1C,halo
191342,Add a amide to the molecule O=C(NC[C@@H](c1ccccc1Cl)N1CCOCC1)Nc1cccc([N+](=O)[O-])c1.,O=C(NC[C@@H](c1ccccc1Cl)N1CCOCC1)Nc1cccc([N+](=O)[O-])c1,amide
469,Modify the molecule COc1ccc(C(=O)OCc2nc3ccccc3s2)cn1 by adding a benzene ring.,COc1ccc(C(=O)OCc2nc3ccccc3s2)cn1,benzene ring
214274,Please add a benzene ring to the molecule O=Cc1c(I)cc(I)c(O)c1I.,O=Cc1c(I)cc(I)c(O)c1I,benzene ring
88728,Modify the molecule CC(C)/C(=C\c1ccc([C@@H]2C[C@@H]2C)o1)C[NH2+]C1CC1 by adding a amine.,CC(C)/C(=C\c1ccc([C@@H]2C[C@@H]2C)o1)C[NH2+]C1CC1,amine
35309,Modify the molecule Nc1cc([C@H]2CCC[NH2+]C2)nc2cc(-c3ccc(F)cc3)nn12 by adding a nitro.,Nc1cc([C@H]2CCC[NH2+]C2)nc2cc(-c3ccc(F)cc3)nn12,nitro
153817,Please add a hydroxyl to the molecule O=[N+]([O-])c1ccc(NC[C@@H]2CCCN(c3ncccn3)C2)c2ncccc12.,O=[N+]([O-])c1ccc(NC[C@@H]2CCCN(c3ncccn3)C2)c2ncccc12,hydroxyl
205402,Modify the molecule CCCC(=O)N1c2ncnn2[C@H](c2ccccc2OC)C[C@@H]1c1ccc(C)cc1 by adding a amide.,CCCC(=O)N1c2ncnn2[C@H](c2ccccc2OC)C[C@@H]1c1ccc(C)cc1,amide
187445,Modify the molecule CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)CNC(=O)c2cccc(Cl)c2)C1 by adding a hydroxyl.,CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)CNC(=O)c2cccc(Cl)c2)C1,hydroxyl
131145,Modify the molecule COc1ccc(-n2cc(CNC(=O)c3cnn(C)c3)nn2)cc1 by adding a amide.,COc1ccc(-n2cc(CNC(=O)c3cnn(C)c3)nn2)cc1,amide
181847,Please add a amide to the molecule COc1cccc(CNC(=O)[C@@]2(C)CCCN(C(=O)Nc3cccc(Br)c3)C2)c1.,COc1cccc(CNC(=O)[C@@]2(C)CCCN(C(=O)Nc3cccc(Br)c3)C2)c1,amide
208866,Please add a hydroxyl to the molecule COc1ccc(NCc2cccc(OC)c2O)c(OC)c1.,COc1ccc(NCc2cccc(OC)c2O)c(OC)c1,hydroxyl
13305,Please add a benzene ring to the molecule O=[N+]([O-])c1ccc(NCC[NH2+]Cc2c(Cl)cccc2Cl)cc1.,O=[N+]([O-])c1ccc(NCC[NH2+]Cc2c(Cl)cccc2Cl)cc1,benzene ring
38898,Modify the molecule COC(=O)c1ccc(C)c(NC(=O)[C@@H]2CCCN(C(=O)c3ccc(OC)c4ccccc34)C2)c1 by adding a hydroxyl.,COC(=O)c1ccc(C)c(NC(=O)[C@@H]2CCCN(C(=O)c3ccc(OC)c4ccccc34)C2)c1,hydroxyl
42770,Add a aldehyde to the molecule Cc1cc(C)cc(-c2nnc(SCCC(=O)Nc3ccc([N+](=O)[O-])cc3)o2)c1.,Cc1cc(C)cc(-c2nnc(SCCC(=O)Nc3ccc([N+](=O)[O-])cc3)o2)c1,aldehyde
93150,Modify the molecule CCc1c[nH+]c(C)nc1N1CCC[C@H]([NH+]2CCN(c3ccccc3OC)CC2)C1 by adding a thiol.,CCc1c[nH+]c(C)nc1N1CCC[C@H]([NH+]2CCN(c3ccccc3OC)CC2)C1,thiol
107945,Please add a amide to the molecule N#Cc1ccc(OCc2ccc(C(=O)NN)cn2)c(Cl)c1.,N#Cc1ccc(OCc2ccc(C(=O)NN)cn2)c(Cl)c1,amide
42667,Modify the molecule CC1(C)[C@H]2C[NH2+]C[C@@H]2CN1C(=O)c1ccncc1Cl by adding a benzene ring.,CC1(C)[C@H]2C[NH2+]C[C@@H]2CN1C(=O)c1ccncc1Cl,benzene ring
193312,Modify the molecule CC(C)NC(=O)N(C)c1ccc(OCCc2cnn(C)c2)cc1 by adding a benzene ring.,CC(C)NC(=O)N(C)c1ccc(OCCc2cnn(C)c2)cc1,benzene ring
142382,Modify the molecule CC[C@@H](Oc1ccccc1C)C(=O)Nc1cncc(C)c1 by adding a amine.,CC[C@@H](Oc1ccccc1C)C(=O)Nc1cncc(C)c1,amine
138372,Please add a amide to the molecule C[C@H](CCOc1ccccc1)C(=O)N1CCCN(CC(F)(F)F)CC1.,C[C@H](CCOc1ccccc1)C(=O)N1CCCN(CC(F)(F)F)CC1,amide
213984,Please add a amide to the molecule COc1ccc([C@@H]2CC(=O)C3=C(C2)Nc2ccccc2N[C@H]3c2ccsc2)cc1OC.,COc1ccc([C@@H]2CC(=O)C3=C(C2)Nc2ccccc2N[C@H]3c2ccsc2)cc1OC,amide
112160,Modify the molecule CC(C)[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2C[C@H](C)O[C@H](C)C2)c1 by adding a halo.,CC(C)[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2C[C@H](C)O[C@H](C)C2)c1,halo
137016,Please add a amine to the molecule CCSCCOC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccccc1C.,CCSCCOC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccccc1C,amine
42643,Please add a nitro to the molecule C[C@@H]1C(=O)N2CCC[C@H]2C(=O)N1Cc1cccc(F)c1.,C[C@@H]1C(=O)N2CCC[C@H]2C(=O)N1Cc1cccc(F)c1,nitro
167124,Modify the molecule CC(=O)Nc1cccc(C(=O)OCC(=O)Nc2ccc(F)cc2F)c1 by adding a hydroxyl.,CC(=O)Nc1cccc(C(=O)OCC(=O)Nc2ccc(F)cc2F)c1,hydroxyl
54076,Modify the molecule CCn1nc(C)cc1C(=O)Nc1ccc(C(=O)NC(C)C)c(C)c1 by adding a nitro.,CCn1nc(C)cc1C(=O)Nc1ccc(C(=O)NC(C)C)c(C)c1,nitro
215084,Add a halo to the molecule CC[C@H](C)NC(=O)N[C@H](C)CC(C)(C)OC.,CC[C@H](C)NC(=O)N[C@H](C)CC(C)(C)OC,halo
3446,Please add a amide to the molecule O=C(CCC1CCCCC1)NNC(=O)[C@@H](O)c1ccccc1.,O=C(CCC1CCCCC1)NNC(=O)[C@@H](O)c1ccccc1,amide
23434,Add a hydroxyl to the molecule C[C@H](CCc1ccc(O)cc1)NC(=O)N(C)CCc1ccccn1.,C[C@H](CCc1ccc(O)cc1)NC(=O)N(C)CCc1ccccn1,hydroxyl
111949,Please add a nitro to the molecule C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1.,C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1,nitro
130266,Add a benzene ring to the molecule O=C(c1csc(-c2ccccc2)n1)N1CCN(c2ccccc2F)CC1.,O=C(c1csc(-c2ccccc2)n1)N1CCN(c2ccccc2F)CC1,benzene ring
151754,Please add a aldehyde to the molecule C[NH+](C)CC(=O)Nc1ccc(NC(=O)[C@H]2CSc3ccccc32)cc1.,C[NH+](C)CC(=O)Nc1ccc(NC(=O)[C@H]2CSc3ccccc32)cc1,aldehyde
87480,Add a aldehyde to the molecule Cc1ccc(C[NH+](CC(=O)N2CCO[C@@H](C)C2)C2CC2)cc1.,Cc1ccc(C[NH+](CC(=O)N2CCO[C@@H](C)C2)C2CC2)cc1,aldehyde
204094,Add a halo to the molecule CCC[C@@H]1SC[C@@H](C(=O)[O-])N1C(=O)C1C(C)(C)C1(C)C.,CCC[C@@H]1SC[C@@H](C(=O)[O-])N1C(=O)C1C(C)(C)C1(C)C,halo
170042,Please add a hydroxyl to the molecule CC[C@](C)(C#N)[C@]1(O)CCC[NH+](C(C)C)CC1.,CC[C@](C)(C#N)[C@]1(O)CCC[NH+](C(C)C)CC1,hydroxyl
222372,Please add a hydroxyl to the molecule O=C(Nc1cc([O-])nc2nc(C(F)(F)F)nn12)c1ccc(F)cc1.,O=C(Nc1cc([O-])nc2nc(C(F)(F)F)nn12)c1ccc(F)cc1,hydroxyl
197392,Modify the molecule CCN(C(=O)c1cc2c([nH]c1=O)CCCC2=O)[C@H]1CCCC[C@H]1C by adding a amine.,CCN(C(=O)c1cc2c([nH]c1=O)CCCC2=O)[C@H]1CCCC[C@H]1C,amine
16028,Add a hydroxyl to the molecule Cc1cc(C)cc(CN[C@H](C)C(N)=O)c1.,Cc1cc(C)cc(CN[C@H](C)C(N)=O)c1,hydroxyl
34599,Add a amide to the molecule CON(C)c1nc(-c2ccncc2)nc2c1CCC2.,CON(C)c1nc(-c2ccncc2)nc2c1CCC2,amide
149518,Modify the molecule O=C(Nc1nc2ccccc2s1)[C@@H]1CCCN(c2ccc(-n3cccn3)nn2)C1 by adding a amide.,O=C(Nc1nc2ccccc2s1)[C@@H]1CCCN(c2ccc(-n3cccn3)nn2)C1,amide
69849,Please add a benzene ring to the molecule O=C(CCn1ccc(=O)[nH]c1=O)Nc1ccc2c(c1)C(=O)N1CCCC[C@H]1CCO2.,O=C(CCn1ccc(=O)[nH]c1=O)Nc1ccc2c(c1)C(=O)N1CCCC[C@H]1CCO2,benzene ring
159384,Modify the molecule Cc1ccnn1C[C@@H](C)C(=O)NC[C@H](c1cccs1)[NH+]1CCCCCC1 by adding a benzene ring.,Cc1ccnn1C[C@@H](C)C(=O)NC[C@H](c1cccs1)[NH+]1CCCCCC1,benzene ring
87001,Modify the molecule C[C@H](CNC(=O)CCc1ccc(C#N)cc1)N1CCc2ccccc21 by adding a hydroxyl.,C[C@H](CNC(=O)CCc1ccc(C#N)cc1)N1CCc2ccccc21,hydroxyl
64192,Please add a nitro to the molecule C[C@@H]1CCN(C(=O)c2ccccc2[N+](=O)[O-])C[C@@H]1O.,C[C@@H]1CCN(C(=O)c2ccccc2[N+](=O)[O-])C[C@@H]1O,nitro
224781,Modify the molecule C=CC[n+]1c(NC(=O)NCC)sn(CC)c1=O by adding a aldehyde.,C=CC[n+]1c(NC(=O)NCC)sn(CC)c1=O,aldehyde
134179,Please add a amide to the molecule C[C@@H](OC(=O)[C@H]1CSCN1C(=O)C(C)(C)C)c1cnc2ccccc2c1.,C[C@@H](OC(=O)[C@H]1CSCN1C(=O)C(C)(C)C)c1cnc2ccccc2c1,amide
67564,Modify the molecule C[C@@H](Cn1ccnc1)[NH2+]Cc1nncn1C1CCCCC1 by adding a hydroxyl.,C[C@@H](Cn1ccnc1)[NH2+]Cc1nncn1C1CCCCC1,hydroxyl
132779,Please add a aldehyde to the molecule CC(C)CNC(=O)C1(NCc2cccc3cccnc23)CCCC1.,CC(C)CNC(=O)C1(NCc2cccc3cccnc23)CCCC1,aldehyde
114034,Please add a halo to the molecule Cc1cccc(SCC(=O)NC2CCCC2)c1N.,Cc1cccc(SCC(=O)NC2CCCC2)c1N,halo
96831,Add a hydroxyl to the molecule Cc1cn2c(=O)c(C(=O)NCCCc3cccc(F)c3)cnc2s1.,Cc1cn2c(=O)c(C(=O)NCCCc3cccc(F)c3)cnc2s1,hydroxyl
88336,Modify the molecule Cc1cc[nH+]c(N[C@H]2CC[NH2+]C2)c1 by adding a hydroxyl.,Cc1cc[nH+]c(N[C@H]2CC[NH2+]C2)c1,hydroxyl
200723,Add a benzene ring to the molecule CCn1c([C@@H]2CCC[NH+]2Cc2occc2C)nc2ccccc21.,CCn1c([C@@H]2CCC[NH+]2Cc2occc2C)nc2ccccc21,benzene ring
230948,Add a benzene ring to the molecule N#C[C@]1(NC2CC2)CCC[C@H](Sc2cccs2)C1.,N#C[C@]1(NC2CC2)CCC[C@H](Sc2cccs2)C1,benzene ring
113017,Please add a amide to the molecule Cc1nc([C@@]2(C)CCCO2)nc(C)c1C[NH2+]C(C)C.,Cc1nc([C@@]2(C)CCCO2)nc(C)c1C[NH2+]C(C)C,amide
114074,Add a amide to the molecule CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1CCC[C@H](S(C)(=O)=O)C1.,CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1CCC[C@H](S(C)(=O)=O)C1,amide
86303,Add a hydroxyl to the molecule COC(=O)C1=NN[C@@]2(C)C(=O)N(c3ccccc3)C(=O)[C@@H]12.,COC(=O)C1=NN[C@@]2(C)C(=O)N(c3ccccc3)C(=O)[C@@H]12,hydroxyl
100318,Add a hydroxyl to the molecule Cc1cc(NC(=O)CN(C)C(=O)[C@@H](C)Sc2ccc(Br)cc2)no1.,Cc1cc(NC(=O)CN(C)C(=O)[C@@H](C)Sc2ccc(Br)cc2)no1,hydroxyl
122138,Modify the molecule COC(=O)[C@@H](C)CN(C)Cc1ccc([N+](=O)[O-])c(F)c1 by adding a halo.,COC(=O)[C@@H](C)CN(C)Cc1ccc([N+](=O)[O-])c(F)c1,halo
202384,Add a halo to the molecule C[C@@H](CO)NC(=O)NCc1cccc(Cn2ccnc2)c1.,C[C@@H](CO)NC(=O)NCc1cccc(Cn2ccnc2)c1,halo
188009,Please add a benzene ring to the molecule CC[C@@H](C)Oc1cccc(NC(=O)[C@](C)(N)C(F)(F)F)c1.,CC[C@@H](C)Oc1cccc(NC(=O)[C@](C)(N)C(F)(F)F)c1,benzene ring
220524,Modify the molecule COCCOCCn1cc(I)c(=O)[nH]c1=O by adding a nitro.,COCCOCCn1cc(I)c(=O)[nH]c1=O,nitro
10331,Modify the molecule CCOc1cccc(NC(=O)NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c1 by adding a benzene ring.,CCOc1cccc(NC(=O)NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c1,benzene ring
201469,Modify the molecule Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1 by adding a halo.,Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1,halo
180715,Please add a hydroxyl to the molecule O=C1C[C@@H](C(=O)N2CCC[C@@H](c3nnc4ccccn34)C2)CN1CC1CC1.,O=C1C[C@@H](C(=O)N2CCC[C@@H](c3nnc4ccccn34)C2)CN1CC1CC1,hydroxyl
176563,Please add a hydroxyl to the molecule CCC(=O)N1CC[C@@H](C(=O)O[C@@H](c2ccc(F)c(F)c2)C(C)C)C1.,CCC(=O)N1CC[C@@H](C(=O)O[C@@H](c2ccc(F)c(F)c2)C(C)C)C1,hydroxyl
76465,Add a halo to the molecule COC[C@@H]1CCC[NH+]1Cc1cc(C)n(Cc2ccco2)c1C.,COC[C@@H]1CCC[NH+]1Cc1cc(C)n(Cc2ccco2)c1C,halo
159949,Add a hydroxyl to the molecule COCC1CC[NH+](C/C=C/c2ccc(C#N)cc2)CC1.,COCC1CC[NH+](C/C=C/c2ccc(C#N)cc2)CC1,hydroxyl
63084,Please add a hydroxyl to the molecule Cc1ccc(OCCCCN2CC[NH2+]CC2)c(C(C)(C)C)c1.,Cc1ccc(OCCCCN2CC[NH2+]CC2)c(C(C)(C)C)c1,hydroxyl
244049,Please add a hydroxyl to the molecule Cc1cccc([C@@H](C)CNC(=O)c2nccnc2C(N)=O)c1.,Cc1cccc([C@@H](C)CNC(=O)c2nccnc2C(N)=O)c1,hydroxyl
73006,Modify the molecule C[NH+](C)Cc1cccc(NC(=O)N2CCC[C@H]2CCc2ccccc2)c1 by adding a nitro.,C[NH+](C)Cc1cccc(NC(=O)N2CCC[C@H]2CCc2ccccc2)c1,nitro
30776,Modify the molecule Cc1cnc([C@@H](C)NC(=O)c2cnc([C@@H]3CCCO3)s2)s1 by adding a aldehyde.,Cc1cnc([C@@H](C)NC(=O)c2cnc([C@@H]3CCCO3)s2)s1,aldehyde
249374,Modify the molecule CCCCOC(=O)[C@@](C)(N)C(F)(F)F by adding a halo.,CCCCOC(=O)[C@@](C)(N)C(F)(F)F,halo
40602,Please add a amide to the molecule C[C@H]1C[C@@H](N(C)C(=O)c2cn(C)nc2C(C)(C)C)CC[NH+]1C.,C[C@H]1C[C@@H](N(C)C(=O)c2cn(C)nc2C(C)(C)C)CC[NH+]1C,amide
166519,Add a nitro to the molecule COc1ccc(S(=O)(=O)[N-]c2nc(-c3cccc(F)c3)cs2)cc1.,COc1ccc(S(=O)(=O)[N-]c2nc(-c3cccc(F)c3)cs2)cc1,nitro
63536,Please add a hydroxyl to the molecule Cc1cc(C)nc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1.,Cc1cc(C)nc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1,hydroxyl
127012,Add a hydroxyl to the molecule Cc1nnc(SCCC(=O)[O-])s1.,Cc1nnc(SCCC(=O)[O-])s1,hydroxyl
219181,Add a amide to the molecule Cc1onc(-c2ccccc2Cl)c1C(=O)NCC(=O)N1CCO[C@@H](c2ccccc2)C1.,Cc1onc(-c2ccccc2Cl)c1C(=O)NCC(=O)N1CCO[C@@H](c2ccccc2)C1,amide
30430,Modify the molecule CN[C@@H](C[NH+](C)C)c1cc(C)cc(F)c1 by adding a amide.,CN[C@@H](C[NH+](C)C)c1cc(C)cc(F)c1,amide
81944,Please add a amide to the molecule CC(C)c1ccc(CN(C(=O)CN2C(=O)NC3(CCCC3)C2=O)C2CC2)cc1.,CC(C)c1ccc(CN(C(=O)CN2C(=O)NC3(CCCC3)C2=O)C2CC2)cc1,amide
223960,Please add a amide to the molecule C[C@H]([NH2+]Cc1ccco1)c1cccc(C#N)c1.,C[C@H]([NH2+]Cc1ccco1)c1cccc(C#N)c1,amide
106333,Add a amide to the molecule C/[NH+]=C(/NCCc1nc(C(C)C)no1)N1CCN(C(=O)[C@@H]2CCCO2)CC1.,C/[NH+]=C(/NCCc1nc(C(C)C)no1)N1CCN(C(=O)[C@@H]2CCCO2)CC1,amide
185381,Modify the molecule CCOc1ccc2cc(C(=O)Nc3ccc(C(C)=O)cc3)c(=O)oc2c1 by adding a benzene ring.,CCOc1ccc2cc(C(=O)Nc3ccc(C(C)=O)cc3)c(=O)oc2c1,benzene ring
101828,Modify the molecule O=C1[C@H]2CC3=c4ccccc4=[NH+][C@H]3CN2C(=O)CN1/N=C/c1ccccc1Cl by adding a benzene ring.,O=C1[C@H]2CC3=c4ccccc4=[NH+][C@H]3CN2C(=O)CN1/N=C/c1ccccc1Cl,benzene ring
134484,Please add a hydroxyl to the molecule Cc1cc(OCC(=O)OC(C)C)cc2c1C(=O)/C(=C/c1cc(Br)cc3c1OCOC3)O2.,Cc1cc(OCC(=O)OC(C)C)cc2c1C(=O)/C(=C/c1cc(Br)cc3c1OCOC3)O2,hydroxyl
115521,Please add a benzene ring to the molecule CCOc1ccc2c(c1)CN(C(=O)N[C@H]1CCCn3c(C)nnc31)CC2.,CCOc1ccc2c(c1)CN(C(=O)N[C@H]1CCCn3c(C)nnc31)CC2,benzene ring
207503,Add a aldehyde to the molecule CCC(=O)Nc1nc(C)cc(C)n1.,CCC(=O)Nc1nc(C)cc(C)n1,aldehyde
168099,Add a amine to the molecule COc1ccc(NC(=O)C(=O)N/N=C/c2coc3ccccc3c2=O)cc1.,COc1ccc(NC(=O)C(=O)N/N=C/c2coc3ccccc3c2=O)cc1,amine
203758,Modify the molecule O=C(CCc1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1nc[nH]n1 by adding a amide.,O=C(CCc1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1nc[nH]n1,amide
222780,Add a aldehyde to the molecule CCC1(CNC(=O)NCCc2nnc3n2CCC3)CCC1.,CCC1(CNC(=O)NCCc2nnc3n2CCC3)CCC1,aldehyde
176351,Please add a benzene ring to the molecule Cc1nn(C)c2ncc(NC(=O)N(C)[C@@H](C)c3ccccc3Cl)cc12.,Cc1nn(C)c2ncc(NC(=O)N(C)[C@@H](C)c3ccccc3Cl)cc12,benzene ring
34031,Modify the molecule CN(C)C(=O)Sc1ccc(CNc2ccc(C#N)cc2)cc1 by adding a amide.,CN(C)C(=O)Sc1ccc(CNc2ccc(C#N)cc2)cc1,amide
108035,Please add a amine to the molecule C/C=C(\C)C(=O)N/N=C/c1cccnc1.,C/C=C(\C)C(=O)N/N=C/c1cccnc1,amine
245237,Modify the molecule COc1cc([C@H]2C3=C(CCCC3=O)Nc3ncnn32)cc(OC)c1O by adding a benzene ring.,COc1cc([C@H]2C3=C(CCCC3=O)Nc3ncnn32)cc(OC)c1O,benzene ring
77859,Modify the molecule CS[C@@H]1CC[C@@H](NC(=O)N[C@@H](CO)c2ccccc2F)C1 by adding a benzene ring.,CS[C@@H]1CC[C@@H](NC(=O)N[C@@H](CO)c2ccccc2F)C1,benzene ring
46843,Add a halo to the molecule CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2ccc3c(c2)OC(F)(F)O3)c1.,CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2ccc3c(c2)OC(F)(F)O3)c1,halo
12603,Please add a hydroxyl to the molecule CCOC[C@@H]1CCCN1C(=O)c1ccc(-n2nc(C)cc2C)cc1.,CCOC[C@@H]1CCCN1C(=O)c1ccc(-n2nc(C)cc2C)cc1,hydroxyl
180900,Add a halo to the molecule CC(C)Cc1cc(C(=O)N[C@@H](CO)C(=O)[O-])n(C)n1.,CC(C)Cc1cc(C(=O)N[C@@H](CO)C(=O)[O-])n(C)n1,halo
148368,Please add a amide to the molecule Cc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)c(C)c1.,Cc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)c(C)c1,amide
98075,Modify the molecule CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1 by adding a halo.,CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1,halo
157205,Add a benzene ring to the molecule CC(C)N[C@](C)(C#N)CCC[NH+]1C[C@H](C)[C@@H](C)C1.,CC(C)N[C@](C)(C#N)CCC[NH+]1C[C@H](C)[C@@H](C)C1,benzene ring
168222,Please add a nitro to the molecule CCS[C@H]1CCCC[C@H]1NC(=O)NCC(=O)N1CCc2ccccc21.,CCS[C@H]1CCCC[C@H]1NC(=O)NCC(=O)N1CCc2ccccc21,nitro
125216,Modify the molecule CC(C)(C)NC(=O)[C@@H]1C[C@H]2CCCC[C@@H]2CN1C(=O)c1ccc(C(F)(F)F)cc1 by adding a hydroxyl.,CC(C)(C)NC(=O)[C@@H]1C[C@H]2CCCC[C@@H]2CN1C(=O)c1ccc(C(F)(F)F)cc1,hydroxyl
174998,Please add a amide to the molecule O=c1cc([O-])cc(-c2ccc(Cl)cc2)o1.,O=c1cc([O-])cc(-c2ccc(Cl)cc2)o1,amide
98030,Modify the molecule Cc1nc2ccccn2c1C(=O)NCC(C)C by adding a benzene ring.,Cc1nc2ccccn2c1C(=O)NCC(C)C,benzene ring
221547,Add a benzene ring to the molecule O=C(COC(=O)c1ccccc1Br)Nc1ccc(F)cc1Cl.,O=C(COC(=O)c1ccccc1Br)Nc1ccc(F)cc1Cl,benzene ring
22609,Add a benzene ring to the molecule COc1ccc(F)cc1[C@@H](C(=O)[O-])[NH+](C)CCn1ccnc1C.,COc1ccc(F)cc1[C@@H](C(=O)[O-])[NH+](C)CCn1ccnc1C,benzene ring
160890,Modify the molecule O=C(NC1CC1)c1cn(-c2ccc(-c3nc(C4CC4)no3)cn2)cn1 by adding a carboxyl.,O=C(NC1CC1)c1cn(-c2ccc(-c3nc(C4CC4)no3)cn2)cn1,carboxyl
56570,Modify the molecule CN(c1ccccc1C(=O)Nc1ccccc1Sc1ccccc1)S(C)(=O)=O by adding a nitro.,CN(c1ccccc1C(=O)Nc1ccccc1Sc1ccccc1)S(C)(=O)=O,nitro
80482,Add a benzene ring to the molecule Clc1ccc([C@H](CNCc2csc(C3CC3)n2)n2cccn2)cc1.,Clc1ccc([C@H](CNCc2csc(C3CC3)n2)n2cccn2)cc1,benzene ring
86286,Modify the molecule CC(=O)Nc1cc(NC(=O)NCCCC[NH+]2CCCC2)ccc1C by adding a benzene ring.,CC(=O)Nc1cc(NC(=O)NCCCC[NH+]2CCCC2)ccc1C,benzene ring
40862,Modify the molecule Cc1cccc(C)c1NC(=O)CN(C)c1ncnc2[nH]ncc12 by adding a hydroxyl.,Cc1cccc(C)c1NC(=O)CN(C)c1ncnc2[nH]ncc12,hydroxyl
78379,Modify the molecule CCc1cccc(C)c1NC(=O)[C@@H]1CC(=O)N(c2ccccc2OC)C1 by adding a hydroxyl.,CCc1cccc(C)c1NC(=O)[C@@H]1CC(=O)N(c2ccccc2OC)C1,hydroxyl
124628,Add a nitro to the molecule C[NH+](CCOC(F)(F)F)CC(C)(C)O.,C[NH+](CCOC(F)(F)F)CC(C)(C)O,nitro
167214,Modify the molecule Cc1c(C(=O)NCCn2c(C)cc3ccccc32)cccc1[N+](=O)[O-] by adding a benzene ring.,Cc1c(C(=O)NCCn2c(C)cc3ccccc32)cccc1[N+](=O)[O-],benzene ring
63679,Please add a amide to the molecule C[C@@H]1CCCC[C@@H]1OCc1ccc(N)c2cccnc12.,C[C@@H]1CCCC[C@@H]1OCc1ccc(N)c2cccnc12,amide
114076,Modify the molecule COCc1nc2cc(Cl)ccc2[nH]1 by adding a hydroxyl.,COCc1nc2cc(Cl)ccc2[nH]1,hydroxyl
245269,Please add a amine to the molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(NS(C)(=O)=O)cc1.,Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(NS(C)(=O)=O)cc1,amine
175168,Modify the molecule Cc1cc(NC(=O)C(=O)N2CC=C(c3ccc(Cl)cc3)CC2)n(C)n1 by adding a hydroxyl.,Cc1cc(NC(=O)C(=O)N2CC=C(c3ccc(Cl)cc3)CC2)n(C)n1,hydroxyl
120969,Modify the molecule Cc1noc(COc2ccccc2-c2ccccc2)n1 by adding a hydroxyl.,Cc1noc(COc2ccccc2-c2ccccc2)n1,hydroxyl
112668,Modify the molecule O=C(c1cn[nH]c1-c1cccc(Cl)c1)N1CCN(c2ccc(F)cc2)CC1 by adding a halo.,O=C(c1cn[nH]c1-c1cccc(Cl)c1)N1CCN(c2ccc(F)cc2)CC1,halo
8255,Add a carboxyl to the molecule O=C(Nc1c[nH]nc1-c1ccccn1)N1CC[C@H](CO)C1.,O=C(Nc1c[nH]nc1-c1ccccn1)N1CC[C@H](CO)C1,carboxyl
63284,Please add a aldehyde to the molecule Cc1cc2nc(C(C)C)cc(N[C@@H](c3nc(C4CC4)no3)C(C)C)n2n1.,Cc1cc2nc(C(C)C)cc(N[C@@H](c3nc(C4CC4)no3)C(C)C)n2n1,aldehyde
240521,Modify the molecule CCC1CCC(C[C@@H](O)C(F)(F)F)(C(=O)[O-])CC1 by adding a aldehyde.,CCC1CCC(C[C@@H](O)C(F)(F)F)(C(=O)[O-])CC1,aldehyde
131768,Modify the molecule COc1cc(C)c(Br)cc1C(=O)c1c(F)ccc(N)c1F by adding a nitrile.,COc1cc(C)c(Br)cc1C(=O)c1c(F)ccc(N)c1F,nitrile
223876,Add a amide to the molecule COC(=O)c1ccc([N+](=O)[O-])c(OCC(C)C)c1.,COC(=O)c1ccc([N+](=O)[O-])c(OCC(C)C)c1,amide
41280,Modify the molecule CCOCc1ccccc1NC(=O)C1=Cc2cc(F)ccc2OC1 by adding a hydroxyl.,CCOCc1ccccc1NC(=O)C1=Cc2cc(F)ccc2OC1,hydroxyl
12808,Modify the molecule CC(C)C[C@H]1[C@H]2C[C@H](C)CC=C2C(C#N)=C(N)C1(C#N)C#N by adding a amide.,CC(C)C[C@H]1[C@H]2C[C@H](C)CC=C2C(C#N)=C(N)C1(C#N)C#N,amide
197093,Add a benzene ring to the molecule O=C(NC1CCCCC1)[C@H]1C[C@H](O)CN1C(=O)Nc1ccccc1.,O=C(NC1CCCCC1)[C@H]1C[C@H](O)CN1C(=O)Nc1ccccc1,benzene ring
104071,Modify the molecule CC(C)(C)OC(=O)NC[C@@H]1CCCN1C(=O)c1ccc(Cl)cn1 by adding a benzene ring.,CC(C)(C)OC(=O)NC[C@@H]1CCCN1C(=O)c1ccc(Cl)cn1,benzene ring
243024,Modify the molecule CNC(=O)[C@@H]1CCC[NH+](Cc2ccc(-c3ccc(OC)cc3[N+](=O)[O-])o2)C1 by adding a halo.,CNC(=O)[C@@H]1CCC[NH+](Cc2ccc(-c3ccc(OC)cc3[N+](=O)[O-])o2)C1,halo
188720,Add a halo to the molecule Cc1nc(NC(=O)N[C@H]2CCOC2)ccc1Br.,Cc1nc(NC(=O)N[C@H]2CCOC2)ccc1Br,halo
123467,Add a halo to the molecule C[C@@H](NC(=O)c1ccccc1)C(=O)N[C@H](C)c1ccccc1Cl.,C[C@@H](NC(=O)c1ccccc1)C(=O)N[C@H](C)c1ccccc1Cl,halo
34143,Please add a amide to the molecule CCCOc1ccccc1NC(=O)c1coc(Br)c1.,CCCOc1ccccc1NC(=O)c1coc(Br)c1,amide
45166,Add a benzene ring to the molecule NC(=O)CCSc1ccccc1NC(=O)Cc1cccc(F)c1.,NC(=O)CCSc1ccccc1NC(=O)Cc1cccc(F)c1,benzene ring
198651,Modify the molecule O=C(NCC1C2CC3CC(C2)CC1C3)c1ccc(C[NH+]2CCCCCC2)[nH]c1=O by adding a amide.,O=C(NCC1C2CC3CC(C2)CC1C3)c1ccc(C[NH+]2CCCCCC2)[nH]c1=O,amide
189597,Add a nitrile to the molecule CC[NH+]1CC[C@H](N(C)Cc2cnc(-c3ccccn3)s2)[C@H](C)C1.,CC[NH+]1CC[C@H](N(C)Cc2cnc(-c3ccccn3)s2)[C@H](C)C1,nitrile
146095,Add a hydroxyl to the molecule COc1ccc(/C=C/C(=O)N2CCC(C3[NH+]=c4ccccc4=[NH+]3)CC2)cc1.,COc1ccc(/C=C/C(=O)N2CCC(C3[NH+]=c4ccccc4=[NH+]3)CC2)cc1,hydroxyl
60520,Please add a benzene ring to the molecule CS(=O)(=O)NCC[C@@H]1CCCC[NH+]1Cc1nnnn1C1CC1.,CS(=O)(=O)NCC[C@@H]1CCCC[NH+]1Cc1nnnn1C1CC1,benzene ring
135350,Add a hydroxyl to the molecule Cc1ccc([C@H](C)N(C)C(=O)NCCN2CCOCC2)cc1.,Cc1ccc([C@H](C)N(C)C(=O)NCCN2CCOCC2)cc1,hydroxyl
48854,Modify the molecule CSc1nnc(CN(C)[C@H]2CCSC2)s1 by adding a aldehyde.,CSc1nnc(CN(C)[C@H]2CCSC2)s1,aldehyde
106395,Please add a nitro to the molecule C[C@@H]1C[C@H]1NC(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1.,C[C@@H]1C[C@H]1NC(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1,nitro
222449,Add a benzene ring to the molecule CC[C@@H]1C(=O)N2CCCC[C@@H]2C(=O)N1CCCS(C)(=O)=O.,CC[C@@H]1C(=O)N2CCCC[C@@H]2C(=O)N1CCCS(C)(=O)=O,benzene ring
246086,Please add a carboxyl to the molecule CCn1cc2c(C(F)F)cc(=O)n(CCC(=O)Nc3cccc(C(F)(F)F)c3)c2n1.,CCn1cc2c(C(F)F)cc(=O)n(CCC(=O)Nc3cccc(C(F)(F)F)c3)c2n1,carboxyl
110848,Modify the molecule O=C(c1cc(-c2ccccc2)on1)N1CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 by adding a hydroxyl.,O=C(c1cc(-c2ccccc2)on1)N1CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1,hydroxyl
85101,Please add a benzene ring to the molecule CO[C@@]1(C)C[C@H]([NH2+]Cc2cccc(OCC#N)c2)C1(C)C.,CO[C@@]1(C)C[C@H]([NH2+]Cc2cccc(OCC#N)c2)C1(C)C,benzene ring
98323,Modify the molecule CC(C)CCC(=O)Nc1cc(-c2ccncc2)n[nH]1 by adding a aldehyde.,CC(C)CCC(=O)Nc1cc(-c2ccncc2)n[nH]1,aldehyde
126042,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1NC(=O)N[C@H]1CCCC[C@H]1C by adding a amine.,Cc1nn(-c2ccccc2)c(C)c1NC(=O)N[C@H]1CCCC[C@H]1C,amine
80756,Modify the molecule CCc1noc(C)c1C(=O)N1CC[C@@]2(CCC[NH+](Cc3cccc(OC)c3OC)C2)C1 by adding a hydroxyl.,CCc1noc(C)c1C(=O)N1CC[C@@]2(CCC[NH+](Cc3cccc(OC)c3OC)C2)C1,hydroxyl
209213,Modify the molecule COc1ccc(C)cc1Nc1c([N+](=O)[O-])nn(-c2ccccc2C)[n+]1[O-] by adding a amide.,COc1ccc(C)cc1Nc1c([N+](=O)[O-])nn(-c2ccccc2C)[n+]1[O-],amide
136645,Modify the molecule COC1CC[NH+]([C@H]2CC[C@](NC3CC3)(C(N)=O)C2)CC1 by adding a aldehyde.,COC1CC[NH+]([C@H]2CC[C@](NC3CC3)(C(N)=O)C2)CC1,aldehyde
103469,Modify the molecule Cc1nc(-c2ccc(NC(=O)c3cc4ccccc4oc3=O)cc2)cs1 by adding a nitro.,Cc1nc(-c2ccc(NC(=O)c3cc4ccccc4oc3=O)cc2)cs1,nitro
183415,Modify the molecule CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1 by adding a amide.,CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1,amide
161154,Please add a amine to the molecule COC(=O)c1sccc1C[NH+]1CCCC[C@H]1CCO.,COC(=O)c1sccc1C[NH+]1CCCC[C@H]1CCO,amine
165077,Add a carboxyl to the molecule COC(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1.,COC(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1,carboxyl
183725,Modify the molecule CN(CC1=NC(=O)C2=C3CCC[C@@H]3SC2=N1)Cc1cccc(F)c1 by adding a amide.,CN(CC1=NC(=O)C2=C3CCC[C@@H]3SC2=N1)Cc1cccc(F)c1,amide
91669,Please add a benzene ring to the molecule COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1.,COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1,benzene ring
241854,Please add a benzene ring to the molecule CCOCCN(C)CN1C[C@@H](c2ccccc2)CC1=O.,CCOCCN(C)CN1C[C@@H](c2ccccc2)CC1=O,benzene ring
93591,Modify the molecule Cc1noc(C)c1-c1n[nH]c2c1CN(S(=O)(=O)c1ccsc1)CC2 by adding a benzene ring.,Cc1noc(C)c1-c1n[nH]c2c1CN(S(=O)(=O)c1ccsc1)CC2,benzene ring
29302,Modify the molecule CCc1onc(C)c1NC(=O)[C@H]1CCCN1C(=O)Cc1cccs1 by adding a benzene ring.,CCc1onc(C)c1NC(=O)[C@H]1CCCN1C(=O)Cc1cccs1,benzene ring
167486,Modify the molecule COc1ccc2c(c1)C[C@@H](NC(=O)N1CCN(c3cccc(Cl)c3)CC1)CO2 by adding a hydroxyl.,COc1ccc2c(c1)C[C@@H](NC(=O)N1CCN(c3cccc(Cl)c3)CC1)CO2,hydroxyl
70538,Modify the molecule C[C@@H](Oc1ccccc1Cl)C(=O)Nc1cccc(I)c1 by adding a benzene ring.,C[C@@H](Oc1ccccc1Cl)C(=O)Nc1cccc(I)c1,benzene ring
196570,Add a thiol to the molecule CCn1cc(C(=O)N[C@@H](CC(C)C)C(=O)N2CCN(C)CC2)c(=O)c2cc3c(cc21)OCO3.,CCn1cc(C(=O)N[C@@H](CC(C)C)C(=O)N2CCN(C)CC2)c(=O)c2cc3c(cc21)OCO3,thiol
228396,Modify the molecule CC(C)(CNC(=O)/C=C/C1CC1)c1ccccc1Cl by adding a aldehyde.,CC(C)(CNC(=O)/C=C/C1CC1)c1ccccc1Cl,aldehyde
35811,Add a benzene ring to the molecule CC(C)c1ocnc1CN(C)Cc1cc([N+](=O)[O-])ccc1Cl.,CC(C)c1ocnc1CN(C)Cc1cc([N+](=O)[O-])ccc1Cl,benzene ring
195472,Please add a nitro to the molecule CC(C)C(=O)Cn1nnc2ccccc21.,CC(C)C(=O)Cn1nnc2ccccc21,nitro
20719,Please add a hydroxyl to the molecule CC(C)CO[C@H]1CC[NH+](Cc2c[nH]nc2-c2ccccc2)C1.,CC(C)CO[C@H]1CC[NH+](Cc2c[nH]nc2-c2ccccc2)C1,hydroxyl
3343,Please add a nitro to the molecule O=C(Nc1cccc(OC[C@H]2CCCO2)c1)N1CCC[C@@H](CO)C1.,O=C(Nc1cccc(OC[C@H]2CCCO2)c1)N1CCC[C@@H](CO)C1,nitro
226065,Add a nitro to the molecule c1ccc(CC[NH+]2CCCN(Cc3noc(C4CC4)n3)CC2)cc1.,c1ccc(CC[NH+]2CCCN(Cc3noc(C4CC4)n3)CC2)cc1,nitro
34152,Modify the molecule COc1ccccc1[C@@H]1S[C@H](C)C(=O)N1c1c(C)n(C)n(-c2ccccc2)c1=O by adding a aldehyde.,COc1ccccc1[C@@H]1S[C@H](C)C(=O)N1c1c(C)n(C)n(-c2ccccc2)c1=O,aldehyde
26398,Add a carboxyl to the molecule O=C(OCC(=O)N1CCOCC1)c1ccccc1F.,O=C(OCC(=O)N1CCOCC1)c1ccccc1F,carboxyl
149563,Add a carboxyl to the molecule CCOC[C@H]1CCCN(C(=O)/C=C/c2cccc(Cl)c2Cl)C1.,CCOC[C@H]1CCCN(C(=O)/C=C/c2cccc(Cl)c2Cl)C1,carboxyl
149546,Please add a thiol to the molecule CCC(=O)N1CCC(N2C[C@@H](CO)OC[C@@H]2C)CC1.,CCC(=O)N1CCC(N2C[C@@H](CO)OC[C@@H]2C)CC1,thiol
68903,Add a carboxyl to the molecule CCOC(=O)NCCC(=O)Nc1ccc2c(c1)COC2.,CCOC(=O)NCCC(=O)Nc1ccc2c(c1)COC2,carboxyl
62158,Please add a benzene ring to the molecule C[C@H]1CC(=O)Nc2ccccc2N1C(=O)CN(C)C(=O)c1ccc(=O)[nH]c1.,C[C@H]1CC(=O)Nc2ccccc2N1C(=O)CN(C)C(=O)c1ccc(=O)[nH]c1,benzene ring
50551,Modify the molecule NC(=O)c1c(NC(=O)COC(=O)C2CCC2)sc2c1CCC2 by adding a hydroxyl.,NC(=O)c1c(NC(=O)COC(=O)C2CCC2)sc2c1CCC2,hydroxyl
197758,Modify the molecule C1CCC([NH2+]CCN2CCOCC2)CC1 by adding a amide.,C1CCC([NH2+]CCN2CCOCC2)CC1,amide
210919,Add a benzene ring to the molecule C#CCCOc1ccc(F)cc1C(C)=O.,C#CCCOc1ccc(F)cc1C(C)=O,benzene ring
74254,Please add a nitrile to the molecule COC(=O)c1cc(O)c2c(c1)OC(C)(C)C2.,COC(=O)c1cc(O)c2c(c1)OC(C)(C)C2,nitrile
83035,Add a hydroxyl to the molecule CC(C)CCO[C@@H]1CCN(C(=O)Nc2cc(C#N)ccc2OC(C)C)C1.,CC(C)CCO[C@@H]1CCN(C(=O)Nc2cc(C#N)ccc2OC(C)C)C1,hydroxyl
125860,Please add a halo to the molecule O=C(c1cn[nH]c1-c1cccc(Br)c1)N1CCN(c2ncccn2)CC1.,O=C(c1cn[nH]c1-c1cccc(Br)c1)N1CCN(c2ncccn2)CC1,halo
4871,Please add a nitro to the molecule C[C@@H](CNC(=O)NCC[C@@H](C)O)Oc1cccc(Cl)c1.,C[C@@H](CNC(=O)NCC[C@@H](C)O)Oc1cccc(Cl)c1,nitro
55694,Modify the molecule CCS[C@H]1CC[C@H](Nc2ccc([N+](=O)[O-])cc2C(N)=O)C1 by adding a benzene ring.,CCS[C@H]1CC[C@H](Nc2ccc([N+](=O)[O-])cc2C(N)=O)C1,benzene ring
42057,Add a nitro to the molecule COc1cccc([C@H]2CCCN2C(=O)c2cccc(CCC(C)(C)O)c2)c1.,COc1cccc([C@H]2CCCN2C(=O)c2cccc(CCC(C)(C)O)c2)c1,nitro
144028,Add a aldehyde to the molecule CCC1(CC)C[NH+]([C@H]2CCCCC[C@H]2[NH3+])C1.,CCC1(CC)C[NH+]([C@H]2CCCCC[C@H]2[NH3+])C1,aldehyde
4253,Add a halo to the molecule COc1cccc(C(=O)NC(C)(C)c2nc(C)cs2)c1F.,COc1cccc(C(=O)NC(C)(C)c2nc(C)cs2)c1F,halo
49421,Modify the molecule CN(CCCCCBr)C[C@H]1CCC[NH+]1C by adding a amide.,CN(CCCCCBr)C[C@H]1CCC[NH+]1C,amide
191458,Add a halo to the molecule CC(C)CC(=O)N1C(=O)[C@H]2CCCCN2C(=O)c2ccccc21.,CC(C)CC(=O)N1C(=O)[C@H]2CCCCN2C(=O)c2ccccc21,halo
5359,Modify the molecule C[C@@H]1CCCC[C@@H]1NC(=O)c1cc(S(=O)(=O)N(C)C)ccc1N1CCCCC1 by adding a amide.,C[C@@H]1CCCC[C@@H]1NC(=O)c1cc(S(=O)(=O)N(C)C)ccc1N1CCCCC1,amide
39773,Add a hydroxyl to the molecule CCCC(=O)Nc1cccc(CNc2nc(-c3ccccn3)nc(C)c2C)c1.,CCCC(=O)Nc1cccc(CNc2nc(-c3ccccn3)nc(C)c2C)c1,hydroxyl
61301,Add a thiol to the molecule COCCN(Cc1ccccn1)C(=O)N[C@H]1CCCC[C@@H]1C.,COCCN(Cc1ccccn1)C(=O)N[C@H]1CCCC[C@@H]1C,thiol
148072,Please add a benzene ring to the molecule C[C@H](NC(=O)[C@@H]1CC[C@H](C[NH3+])O1)c1ccc(C#N)cc1.,C[C@H](NC(=O)[C@@H]1CC[C@H](C[NH3+])O1)c1ccc(C#N)cc1,benzene ring
232537,Modify the molecule Cc1ccc(C(=O)N2CCC3=c4ccccc4=[NH+][C@@H]3[C@H]2c2ccc([N+](=O)[O-])cc2)cc1 by adding a amine.,Cc1ccc(C(=O)N2CCC3=c4ccccc4=[NH+][C@@H]3[C@H]2c2ccc([N+](=O)[O-])cc2)cc1,amine
138529,Please add a hydroxyl to the molecule CC(C)(C)c1cc(=O)[nH]c2cc(NC(=O)[C@@H]3CC(=O)N(c4ccccc4)C3)ccc12.,CC(C)(C)c1cc(=O)[nH]c2cc(NC(=O)[C@@H]3CC(=O)N(c4ccccc4)C3)ccc12,hydroxyl
64117,Add a amide to the molecule CC(C)n1c(SCC(=O)Nc2nc(-c3ccc(F)cc3)cs2)nc2ccccc2c1=O.,CC(C)n1c(SCC(=O)Nc2nc(-c3ccc(F)cc3)cs2)nc2ccccc2c1=O,amide
123392,Modify the molecule COC(=O)c1c(NC(=O)c2cc(C)no2)c(C)nn1C by adding a halo.,COC(=O)c1c(NC(=O)c2cc(C)no2)c(C)nn1C,halo
6291,Modify the molecule CN(C)c1ccc([C@H](O)CNC(=O)CC2CCCCC2)cc1 by adding a benzene ring.,CN(C)c1ccc([C@H](O)CNC(=O)CC2CCCCC2)cc1,benzene ring
12189,Modify the molecule CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O by adding a benzene ring.,CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O,benzene ring
36787,Please add a benzene ring to the molecule CN(C)C(=O)CCc1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1.,CN(C)C(=O)CCc1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1,benzene ring
120067,Modify the molecule C[C@H]1CN(C(=O)C(=O)Nc2ccccc2N2CCCCC2)C[C@H](C)O1 by adding a benzene ring.,C[C@H]1CN(C(=O)C(=O)Nc2ccccc2N2CCCCC2)C[C@H](C)O1,benzene ring
234993,Add a hydroxyl to the molecule C/C(=N/NC(=O)COc1ccc(F)cc1)c1ccc(F)cc1.,C/C(=N/NC(=O)COc1ccc(F)cc1)c1ccc(F)cc1,hydroxyl
215297,Modify the molecule CC(C)(c1ccccc1)c1ccc(OCC[NH+]2CCCC2)cc1 by adding a benzene ring.,CC(C)(c1ccccc1)c1ccc(OCC[NH+]2CCCC2)cc1,benzene ring
58019,Modify the molecule CCc1noc(CC)c1CNC(=O)Nc1cccc(-c2nnnn2CC)c1 by adding a aldehyde.,CCc1noc(CC)c1CNC(=O)Nc1cccc(-c2nnnn2CC)c1,aldehyde
155958,Modify the molecule N#Cc1ccsc1NC(=O)CN1C(=O)NC2(CCCCCCC2)C1=O by adding a amide.,N#Cc1ccsc1NC(=O)CN1C(=O)NC2(CCCCCCC2)C1=O,amide
54860,Add a halo to the molecule O=C(CCC1CCCC1)N1CCc2nc(-c3cnccn3)nc(O)c2C1.,O=C(CCC1CCCC1)N1CCc2nc(-c3cnccn3)nc(O)c2C1,halo
232086,Add a benzene ring to the molecule O=[N+]([O-])c1ccccc1SN1CCc2ccccc2C1.,O=[N+]([O-])c1ccccc1SN1CCc2ccccc2C1,benzene ring
30692,Modify the molecule CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1 by adding a benzene ring.,CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1,benzene ring
200570,Modify the molecule CCCc1nc(C(=O)N2CCC[NH+]3CCC[C@@H]3C2)n[nH]1 by adding a aldehyde.,CCCc1nc(C(=O)N2CCC[NH+]3CCC[C@@H]3C2)n[nH]1,aldehyde
93813,Modify the molecule CCN(C(=O)CSC[C@@H](C)CO)c1nc2ccccc2s1 by adding a hydroxyl.,CCN(C(=O)CSC[C@@H](C)CO)c1nc2ccccc2s1,hydroxyl
24597,Add a aldehyde to the molecule Cc1ccccc1CCNC(=O)C[S@](=O)C1CCCCC1.,Cc1ccccc1CCNC(=O)C[S@](=O)C1CCCCC1,aldehyde
204630,Please add a amide to the molecule Cc1sc2nc(CN3CC[C@@H]4[C@H](CCC[NH+]4C4CC4)C3)nc(N)c2c1C.,Cc1sc2nc(CN3CC[C@@H]4[C@H](CCC[NH+]4C4CC4)C3)nc(N)c2c1C,amide
128347,Modify the molecule CN(Cc1ccccc1F)C(=O)NCCc1c(F)cccc1F by adding a amine.,CN(Cc1ccccc1F)C(=O)NCCc1c(F)cccc1F,amine
106941,Modify the molecule C[C@@H](C(=O)c1ccccc1)n1cnc2ccc(F)cc2c1=O by adding a amide.,C[C@@H](C(=O)c1ccccc1)n1cnc2ccc(F)cc2c1=O,amide
206477,Please add a amide to the molecule Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1.,Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1,amide
160410,Modify the molecule CC(C)C1=NN2C(=N)/C(=C/c3cn(Cc4ccccc4[N+](=O)[O-])c4ccccc34)C(=O)N=C2S1 by adding a benzene ring.,CC(C)C1=NN2C(=N)/C(=C/c3cn(Cc4ccccc4[N+](=O)[O-])c4ccccc34)C(=O)N=C2S1,benzene ring
58678,Add a nitrile to the molecule CN1CCO[C@@H]([C@H](O)Cc2ccncc2)C1.,CN1CCO[C@@H]([C@H](O)Cc2ccncc2)C1,nitrile
109267,Add a hydroxyl to the molecule C[C@@H]1SCCC[C@@H]1N[C@@H]1CC[NH+]2CCC[C@H]12.,C[C@@H]1SCCC[C@@H]1N[C@@H]1CC[NH+]2CCC[C@H]12,hydroxyl
122636,Modify the molecule NC(=O)N1CCC[C@@H](C(=O)Nc2ccnn2Cc2ccc(Cl)cc2)C1 by adding a amide.,NC(=O)N1CCC[C@@H](C(=O)Nc2ccnn2Cc2ccc(Cl)cc2)C1,amide
185180,Add a carboxyl to the molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)c2ccc(NC(=O)C(C)C)cc2)cc1.,Cc1ccc(CNC(=O)c2ccccc2NC(=O)c2ccc(NC(=O)C(C)C)cc2)cc1,carboxyl
23939,Modify the molecule COC(=O)[C@H]1CN(C(=O)c2sc(C)nc2C)C[C@H]1C by adding a carboxyl.,COC(=O)[C@H]1CN(C(=O)c2sc(C)nc2C)C[C@H]1C,carboxyl
135440,Please add a aldehyde to the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)Nc2ccc(OC3CCCC3)cc2)C1.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)Nc2ccc(OC3CCCC3)cc2)C1,aldehyde
102278,Modify the molecule CN1C[C@H](C(=O)Nc2cccc(OC[C@@H]3CCCO3)c2)CC1=O by adding a halo.,CN1C[C@H](C(=O)Nc2cccc(OC[C@@H]3CCCO3)c2)CC1=O,halo
11067,Please add a hydroxyl to the molecule Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1.,Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1,hydroxyl
233304,Modify the molecule C[NH+](Cc1ccc(C(=O)[O-])cc1)[C@H]1CC(C)(C)OC1(C)C by adding a amide.,C[NH+](Cc1ccc(C(=O)[O-])cc1)[C@H]1CC(C)(C)OC1(C)C,amide
4213,Add a nitro to the molecule C[C@@H](OC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O)C(=O)Nc1ccc(F)cc1.,C[C@@H](OC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O)C(=O)Nc1ccc(F)cc1,nitro
134323,Add a hydroxyl to the molecule C[NH2+][C@H](Cc1ccc(OC)c(Br)c1)[C@H]1CSCCS1.,C[NH2+][C@H](Cc1ccc(OC)c(Br)c1)[C@H]1CSCCS1,hydroxyl
208053,Please add a benzene ring to the molecule CCN(Cc1ccccn1)S(=O)(=O)c1ccc(F)c(NC(C)=O)c1.,CCN(Cc1ccccn1)S(=O)(=O)c1ccc(F)c(NC(C)=O)c1,benzene ring
167907,Add a halo to the molecule C[C@H]1C[C@@H]1COC(=O)CCNC(=O)c1ccsc1.,C[C@H]1C[C@@H]1COC(=O)CCNC(=O)c1ccsc1,halo
210954,Modify the molecule COc1cccc([C@@H]2CC(=O)C3=C(C2)NC(=O)C[C@H]3c2ccc(OC)c(OC)c2OC)c1 by adding a benzene ring.,COc1cccc([C@@H]2CC(=O)C3=C(C2)NC(=O)C[C@H]3c2ccc(OC)c(OC)c2OC)c1,benzene ring
97645,Modify the molecule COc1ccccc1[C@@H]1C2=C(C[C@@H](c3ccc(O)cc3)CC2=O)Nc2onc(C)c21 by adding a hydroxyl.,COc1ccccc1[C@@H]1C2=C(C[C@@H](c3ccc(O)cc3)CC2=O)Nc2onc(C)c21,hydroxyl
44824,Add a amide to the molecule Cc1onc(-c2ccc(F)cc2)c1C(=O)NCc1ccnc(Oc2ccccc2)c1.,Cc1onc(-c2ccc(F)cc2)c1C(=O)NCc1ccnc(Oc2ccccc2)c1,amide
90396,Modify the molecule CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl by adding a amine.,CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl,amine
20222,Please add a hydroxyl to the molecule COc1ccc(OCC2CC[NH+](CC(=O)Nc3ccn(C)n3)CC2)cc1.,COc1ccc(OCC2CC[NH+](CC(=O)Nc3ccn(C)n3)CC2)cc1,hydroxyl
73320,Please add a amine to the molecule CCC(=O)N1CCC(Cc2cc(NC3CCCC3)nc(C)[nH+]2)CC1.,CCC(=O)N1CCC(Cc2cc(NC3CCCC3)nc(C)[nH+]2)CC1,amine
25525,Add a benzene ring to the molecule [NH3+]CC1([C@@H](O)c2ccc3ccccc3n2)CCCCC1.,[NH3+]CC1([C@@H](O)c2ccc3ccccc3n2)CCCCC1,benzene ring
235183,Please add a aldehyde to the molecule COc1ccc([N-]S(=O)(=O)c2ccccc2[N+](=O)[O-])cn1.,COc1ccc([N-]S(=O)(=O)c2ccccc2[N+](=O)[O-])cn1,aldehyde
126879,Please add a nitro to the molecule CCc1ccc(O)c(NC(=O)CO[C@H]2CCC[C@H](C)C2)c1.,CCc1ccc(O)c(NC(=O)CO[C@H]2CCC[C@H](C)C2)c1,nitro
245573,Add a benzene ring to the molecule CC1(C)CN(C(=O)C2CCN(C(=O)CCOc3ccccc3)CC2)C1(C)C.,CC1(C)CN(C(=O)C2CCN(C(=O)CCOc3ccccc3)CC2)C1(C)C,benzene ring
143171,Add a hydroxyl to the molecule COc1ccc2[nH]cc(C(=O)N(C)Cc3ccccc3)c(=O)c2c1.,COc1ccc2[nH]cc(C(=O)N(C)Cc3ccccc3)c(=O)c2c1,hydroxyl
68928,Add a amide to the molecule CC[C@H]1CCCC[C@H]1NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1.,CC[C@H]1CCCC[C@H]1NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1,amide
67574,Modify the molecule CN(C)C(=O)CCNC(=O)N(C)Cc1cccc(Cl)c1 by adding a aldehyde.,CN(C)C(=O)CCNC(=O)N(C)Cc1cccc(Cl)c1,aldehyde
150976,Please add a hydroxyl to the molecule C[C@H]1C[C@H](C)CN(C(=O)c2ccccc2NC(=O)NCCNC(=O)C2CC2)C1.,C[C@H]1C[C@H](C)CN(C(=O)c2ccccc2NC(=O)NCCNC(=O)C2CC2)C1,hydroxyl
51163,Please add a benzene ring to the molecule CC[C@H](NC(=O)c1nccn2ccnc12)c1ccc(C)cc1.,CC[C@H](NC(=O)c1nccn2ccnc12)c1ccc(C)cc1,benzene ring
129117,Add a amine to the molecule CC1(C)C[C@H]2C[C@](C)(C[NH+]2CCC#N)C1.,CC1(C)C[C@H]2C[C@](C)(C[NH+]2CCC#N)C1,amine
206629,Add a hydroxyl to the molecule COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O.,COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O,hydroxyl
95934,Add a benzene ring to the molecule CC[C@H](NC(=O)C(C)(C)C)c1nc(C(F)(F)F)cs1.,CC[C@H](NC(=O)C(C)(C)C)c1nc(C(F)(F)F)cs1,benzene ring
207134,Modify the molecule CCOC(=O)c1nnnn1[C@@H]1CCOC2(CCSCC2)C1 by adding a benzene ring.,CCOC(=O)c1nnnn1[C@@H]1CCOC2(CCSCC2)C1,benzene ring
176066,Please add a benzene ring to the molecule Cc1cccc(C2=CC[NH+](CCCS(C)(=O)=O)CC2)c1.,Cc1cccc(C2=CC[NH+](CCCS(C)(=O)=O)CC2)c1,benzene ring
239202,Modify the molecule Clc1cc(Cl)cc(C[NH2+]Cc2cccc(CN3CCOCC3)c2)c1 by adding a amide.,Clc1cc(Cl)cc(C[NH2+]Cc2cccc(CN3CCOCC3)c2)c1,amide
34582,Add a amide to the molecule CCO[C@H]1C[C@@H]([O-])C12CC[NH+](Cc1nnc(C3CC3)o1)CC2.,CCO[C@H]1C[C@@H]([O-])C12CC[NH+](Cc1nnc(C3CC3)o1)CC2,amide
192058,Add a halo to the molecule C[C@@H](O[C@H]1CCC[C@@H]1C[NH3+])c1ccccc1.,C[C@@H](O[C@H]1CCC[C@@H]1C[NH3+])c1ccccc1,halo
100099,Modify the molecule O=C(Nc1ccccc1)N1CCC[C@H]1c1nc2ccccc2s1 by adding a amide.,O=C(Nc1ccccc1)N1CCC[C@H]1c1nc2ccccc2s1,amide
116680,Add a amide to the molecule O=C(NCc1ccc2c(c1)OCO2)c1cn(CCC2CCCCC2)nn1.,O=C(NCc1ccc2c(c1)OCO2)c1cn(CCC2CCCCC2)nn1,amide
139855,Add a hydroxyl to the molecule CCOC(=O)C[C@@H](C)Sc1ccncc1.,CCOC(=O)C[C@@H](C)Sc1ccncc1,hydroxyl
195892,Add a halo to the molecule CC(C)(C)c1nnc(NC(=O)Cc2cc(F)ccc2F)s1.,CC(C)(C)c1nnc(NC(=O)Cc2cc(F)ccc2F)s1,halo
181995,Modify the molecule C[C@H](O)[C@H](NC(=O)c1ccc(-c2nnn[n-]2)cc1)C(=O)[O-] by adding a hydroxyl.,C[C@H](O)[C@H](NC(=O)c1ccc(-c2nnn[n-]2)cc1)C(=O)[O-],hydroxyl
82757,Please add a benzene ring to the molecule COc1cc([C@H]2CN3C(=O)CNC(=O)[C@]3(C)c3[nH]c4ccccc4c32)ccc1OC(C)C.,COc1cc([C@H]2CN3C(=O)CNC(=O)[C@]3(C)c3[nH]c4ccccc4c32)ccc1OC(C)C,benzene ring
11383,Please add a benzene ring to the molecule N#Cc1ccccc1NC(=O)C(=O)NC[C@@H](c1ccc(F)cc1)N1CCOCC1.,N#Cc1ccccc1NC(=O)C(=O)NC[C@@H](c1ccc(F)cc1)N1CCOCC1,benzene ring
23357,Add a amine to the molecule O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1.,O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1,amine
33791,Please add a nitrile to the molecule CCc1ccc([C@H](C)NC(=O)CN(C)S(=O)(=O)c2ccc(Cl)nc2)cc1.,CCc1ccc([C@H](C)NC(=O)CN(C)S(=O)(=O)c2ccc(Cl)nc2)cc1,nitrile
178944,Add a benzene ring to the molecule COc1ccccc1OC[C@@H](C)CNc1cnccc1C#N.,COc1ccccc1OC[C@@H](C)CNc1cnccc1C#N,benzene ring
185452,Please add a benzene ring to the molecule Cc1ccccc1C(=O)Nc1ccc(I)cc1C(=O)Nc1ccccn1.,Cc1ccccc1C(=O)Nc1ccc(I)cc1C(=O)Nc1ccccn1,benzene ring
113666,Add a hydroxyl to the molecule O=[N+]([O-])c1ccc(/C=N/c2ccc(Cl)cc2Cl)o1.,O=[N+]([O-])c1ccc(/C=N/c2ccc(Cl)cc2Cl)o1,hydroxyl
157856,Add a nitro to the molecule C[C@H](Nc1ccc2c(c1)NC(=O)[C@@H](C)O2)c1nc(C(C)(C)C)no1.,C[C@H](Nc1ccc2c(c1)NC(=O)[C@@H](C)O2)c1nc(C(C)(C)C)no1,nitro
174982,Modify the molecule CCOC(=O)c1nnnn1CCc1ccsc1 by adding a benzene ring.,CCOC(=O)c1nnnn1CCc1ccsc1,benzene ring
86695,Please add a amine to the molecule C[C@@H]1CN(C(=O)c2ccc3nncn3c2)C[C@@H]1N1CCOCC1.,C[C@@H]1CN(C(=O)c2ccc3nncn3c2)C[C@@H]1N1CCOCC1,amine
329,Please add a aldehyde to the molecule COCCN1[C@@H](C)CN(C(=O)C[NH+](C)C2CC2)C[C@H]1C.,COCCN1[C@@H](C)CN(C(=O)C[NH+](C)C2CC2)C[C@H]1C,aldehyde
126032,Please add a benzene ring to the molecule COc1ccc(OC)c(CN2CC[NH+](Cc3nc4ccc(Cl)cc4c(=O)[nH]3)CC2)c1.,COc1ccc(OC)c(CN2CC[NH+](Cc3nc4ccc(Cl)cc4c(=O)[nH]3)CC2)c1,benzene ring
49775,Modify the molecule CC[NH+](Cc1cc2cc(OC)ccc2[nH]c1=O)[C@@H]1CCS(=O)(=O)C1 by adding a amide.,CC[NH+](Cc1cc2cc(OC)ccc2[nH]c1=O)[C@@H]1CCS(=O)(=O)C1,amide
210585,Modify the molecule COc1ccc(OC)c([C@@H]2CCCN2C(=O)[C@@H](C)Oc2ccc(-n3cnnn3)cc2)c1 by adding a halo.,COc1ccc(OC)c([C@@H]2CCCN2C(=O)[C@@H](C)Oc2ccc(-n3cnnn3)cc2)c1,halo
52288,Modify the molecule CCOc1ccc(-c2cc(C(=O)Nc3cc4c(cc3C)OCCO4)[nH]n2)cc1 by adding a benzene ring.,CCOc1ccc(-c2cc(C(=O)Nc3cc4c(cc3C)OCCO4)[nH]n2)cc1,benzene ring
209519,Please add a carboxyl to the molecule COC(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1.,COC(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1,carboxyl
65218,Modify the molecule COc1ccc(C(F)(F)C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cc1 by adding a hydroxyl.,COc1ccc(C(F)(F)C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cc1,hydroxyl
141858,Please add a benzene ring to the molecule CCCN(CC(F)F)C(=O)N[C@@H]1CC[C@H](SC)C1.,CCCN(CC(F)F)C(=O)N[C@@H]1CC[C@H](SC)C1,benzene ring
145372,Add a benzene ring to the molecule CO[C@H]1CCC[C@H](OC(=O)c2ccc(-n3ccnn3)cc2)C1.,CO[C@H]1CCC[C@H](OC(=O)c2ccc(-n3ccnn3)cc2)C1,benzene ring
104874,Modify the molecule Cc1ccc(OCCCC(=O)N2CCOC[C@@H]2C)cc1C by adding a hydroxyl.,Cc1ccc(OCCCC(=O)N2CCOC[C@@H]2C)cc1C,hydroxyl
239156,Add a nitro to the molecule C[C@H](Oc1ccc(Br)cc1Br)C(=O)N1CCCCCC1.,C[C@H](Oc1ccc(Br)cc1Br)C(=O)N1CCCCCC1,nitro
23206,Add a carboxyl to the molecule Cc1ccc(S(=O)(=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1.,Cc1ccc(S(=O)(=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1,carboxyl
223788,Modify the molecule CN(C(=O)Cn1ncc2ccccc21)C1CCS(=O)CC1 by adding a carboxyl.,CN(C(=O)Cn1ncc2ccccc21)C1CCS(=O)CC1,carboxyl
95497,Modify the molecule CCN(Cc1ccccc1)C(=O)CNC(=O)N[C@@H]1CCC[C@@]1(C)CO by adding a benzene ring.,CCN(Cc1ccccc1)C(=O)CNC(=O)N[C@@H]1CCC[C@@]1(C)CO,benzene ring
206675,Add a aldehyde to the molecule CN(C)C(=O)CNC(=O)CNC(=O)c1cc2sccc2n1C.,CN(C)C(=O)CNC(=O)CNC(=O)c1cc2sccc2n1C,aldehyde
83551,Add a amide to the molecule COC(=O)c1ccc(NC(=O)CNc2cccc(NC(C)=O)c2)cc1.,COC(=O)c1ccc(NC(=O)CNc2cccc(NC(C)=O)c2)cc1,amide
46282,Modify the molecule COC(=O)c1ccc(NC(=O)c2cccc(-c3ccoc3)c2)cc1F by adding a halo.,COC(=O)c1ccc(NC(=O)c2cccc(-c3ccoc3)c2)cc1F,halo
51651,Please add a hydroxyl to the molecule C[C@H]1CC[C@H](C)N(C(=O)NC[C@@H](C)c2nc(-c3ccccc3)no2)C1.,C[C@H]1CC[C@H](C)N(C(=O)NC[C@@H](C)c2nc(-c3ccccc3)no2)C1,hydroxyl
132636,Modify the molecule CC(=O)C[C@@H]1CCCN1S(=O)(=O)N1CCCC1 by adding a carboxyl.,CC(=O)C[C@@H]1CCCN1S(=O)(=O)N1CCCC1,carboxyl
121297,Add a carboxyl to the molecule COC(=O)c1c(NC(=O)N/N=C\c2cccc(OC)c2OC)sc2c1CCCC2.,COC(=O)c1c(NC(=O)N/N=C\c2cccc(OC)c2OC)sc2c1CCCC2,carboxyl
210228,Add a benzene ring to the molecule CSCc1ccc(C(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)o1.,CSCc1ccc(C(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)o1,benzene ring
119607,Modify the molecule CCCN1CCC[C@]2(CC[NH+](Cc3ncccn3)C2)C1=O by adding a hydroxyl.,CCCN1CCC[C@]2(CC[NH+](Cc3ncccn3)C2)C1=O,hydroxyl
64760,Add a benzene ring to the molecule CNc1cccc(CSC[C@H](C)CO)n1.,CNc1cccc(CSC[C@H](C)CO)n1,benzene ring
193995,Modify the molecule CC(C)Oc1ccc([C@@H](CC(=O)[O-])C(=O)[O-])cc1 by adding a halo.,CC(C)Oc1ccc([C@@H](CC(=O)[O-])C(=O)[O-])cc1,halo
198921,Modify the molecule CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1 by adding a aldehyde.,CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1,aldehyde
239707,Modify the molecule C/C(=C\C(=O)NCc1nc(C)no1)C(C)(C)C by adding a benzene ring.,C/C(=C\C(=O)NCc1nc(C)no1)C(C)(C)C,benzene ring
126409,Modify the molecule Cc1cc(NC(=O)[C@H]2[C@@H](C(=O)[O-])C2(C)C)n(-c2ccc(F)cc2)n1 by adding a amide.,Cc1cc(NC(=O)[C@H]2[C@@H](C(=O)[O-])C2(C)C)n(-c2ccc(F)cc2)n1,amide
229005,Please add a hydroxyl to the molecule C[C@@](O)(CNC(=O)N[C@@H](c1ccccc1)C1CCCC1)CN1CCOCC1.,C[C@@](O)(CNC(=O)N[C@@H](c1ccccc1)C1CCCC1)CN1CCOCC1,hydroxyl
159175,Add a aldehyde to the molecule Cc1c(S(=O)(=O)c2ccc(C(C)C)cc2)nnn1-c1ccc(Cl)cc1.,Cc1c(S(=O)(=O)c2ccc(C(C)C)cc2)nnn1-c1ccc(Cl)cc1,aldehyde
45049,Modify the molecule CN(C[C@@H](O)C1CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1 by adding a halo.,CN(C[C@@H](O)C1CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1,halo
16834,Add a halo to the molecule Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)N4CCCCCC4)C3)ncn2)n1.,Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)N4CCCCCC4)C3)ncn2)n1,halo
9988,Please add a amide to the molecule COc1ccc(Br)cc1S(=O)(=O)N1CCCC[C@H]1C.,COc1ccc(Br)cc1S(=O)(=O)N1CCCC[C@H]1C,amide
68069,Add a nitro to the molecule Cc1ncsc1CNC(=O)N[C@@H]1CCCOc2c1ccc1ccccc21.,Cc1ncsc1CNC(=O)N[C@@H]1CCCOc2c1ccc1ccccc21,nitro
78651,Modify the molecule O=C(c1ccc(-n2cnnn2)cc1)N1CCN([C@H]2CCS(=O)(=O)C2)CC1 by adding a amide.,O=C(c1ccc(-n2cnnn2)cc1)N1CCN([C@H]2CCS(=O)(=O)C2)CC1,amide
184673,Add a nitro to the molecule O=C(/C=C/c1cccnc1)N(Cc1ccccn1)c1ccc(F)cc1.,O=C(/C=C/c1cccnc1)N(Cc1ccccn1)c1ccc(F)cc1,nitro
104246,Modify the molecule COc1ccc(S(=O)(=O)NCC#CCOc2cccc(C(F)(F)F)c2)cc1F by adding a amide.,COc1ccc(S(=O)(=O)NCC#CCOc2cccc(C(F)(F)F)c2)cc1F,amide
54650,Please add a amine to the molecule CCCOC(=O)c1oc2c(c1C)/C(=N/NC(=O)c1ccc(C)cc1)CCC2.,CCCOC(=O)c1oc2c(c1C)/C(=N/NC(=O)c1ccc(C)cc1)CCC2,amine
235682,Modify the molecule O=C(c1cnc(-c2ccccc2F)s1)N1CCO[C@H]2CCC[C@H]21 by adding a amide.,O=C(c1cnc(-c2ccccc2F)s1)N1CCO[C@H]2CCC[C@H]21,amide
80600,Please add a amide to the molecule Cc1c(C[NH2+]CC(C)C)cnn1[C@H](C)C1CC1.,Cc1c(C[NH2+]CC(C)C)cnn1[C@H](C)C1CC1,amide
168332,Please add a amide to the molecule Cc1ccc([C@H](C/[NH+]=C/c2ccccc2O)N2CCOCC2)o1.,Cc1ccc([C@H](C/[NH+]=C/c2ccccc2O)N2CCOCC2)o1,amide
155105,Please add a benzene ring to the molecule Cc1cc([C@H]([NH2+]CC2(CO)CCOCC2)C(C)C)c(C)s1.,Cc1cc([C@H]([NH2+]CC2(CO)CCOCC2)C(C)C)c(C)s1,benzene ring
202556,Please add a amide to the molecule Cc1ccc(NC(=O)c2ccco2)cc1NC(=O)COc1ccc([N+](=O)[O-])cc1.,Cc1ccc(NC(=O)c2ccco2)cc1NC(=O)COc1ccc([N+](=O)[O-])cc1,amide
140282,Modify the molecule C=CCNC(=O)[C@@H](C)[NH+](C)[C@@H]1CCN(c2ccccc2Cl)C1=O by adding a amine.,C=CCNC(=O)[C@@H](C)[NH+](C)[C@@H]1CCN(c2ccccc2Cl)C1=O,amine
218028,Please add a hydroxyl to the molecule O=C(COc1cccc(Cl)c1)N/N=C1/C(=O)Nc2ccccc21.,O=C(COc1cccc(Cl)c1)N/N=C1/C(=O)Nc2ccccc21,hydroxyl
29680,Please add a carboxyl to the molecule C[NH+](C[C@H](O)COc1ccc(F)cc1)C[C@H]1CCCO1.,C[NH+](C[C@H](O)COc1ccc(F)cc1)C[C@H]1CCCO1,carboxyl
206588,Modify the molecule CC[NH+](CCNC(=O)[C@H]1CCCN(C(=O)NC2CCCC2)C1)C(C)C by adding a hydroxyl.,CC[NH+](CCNC(=O)[C@H]1CCCN(C(=O)NC2CCCC2)C1)C(C)C,hydroxyl
144219,Please add a hydroxyl to the molecule O=C([O-])[C@@H]1CC=CC[C@@H]1C(=O)n1cccn1.,O=C([O-])[C@@H]1CC=CC[C@@H]1C(=O)n1cccn1,hydroxyl
238194,Add a benzene ring to the molecule Cc1[nH]c2ccc(C(=O)O[C@@H](C)C(=O)Nc3ccc(Cl)cn3)cc2c1C.,Cc1[nH]c2ccc(C(=O)O[C@@H](C)C(=O)Nc3ccc(Cl)cn3)cc2c1C,benzene ring
57997,Please add a benzene ring to the molecule CC(C)(C)[NH2+]CC(=O)NC[C@@H]1CCCO1.,CC(C)(C)[NH2+]CC(=O)NC[C@@H]1CCCO1,benzene ring
106439,Please add a hydroxyl to the molecule O=C1c2ccccc2[C@@H]2OC[C@@H](Cc3ccccc3)N12.,O=C1c2ccccc2[C@@H]2OC[C@@H](Cc3ccccc3)N12,hydroxyl
218216,Please add a amide to the molecule CCC[C@@H](O)c1ccn(CC(=O)Nc2ccc(Cl)cc2)c1.,CCC[C@@H](O)c1ccn(CC(=O)Nc2ccc(Cl)cc2)c1,amide
103141,Modify the molecule O=C(NNC(=O)c1cccc2cn[nH]c12)c1cc(-c2ccccc2)on1 by adding a carboxyl.,O=C(NNC(=O)c1cccc2cn[nH]c12)c1cc(-c2ccccc2)on1,carboxyl
239452,Modify the molecule Cc1nc(C(C)(C)NCc2ccncc2)sc1C by adding a hydroxyl.,Cc1nc(C(C)(C)NCc2ccncc2)sc1C,hydroxyl
150032,Please add a amine to the molecule COC(=O)C1(c2ccccc2)CCN(C(=O)c2cc(C)oc2C)CC1.,COC(=O)C1(c2ccccc2)CCN(C(=O)c2cc(C)oc2C)CC1,amine
3417,Add a amine to the molecule COc1ccc(NC(=O)c2ccc3c(c2)C(=O)N([C@@H](C)c2ccccc2)C3=O)c(OC)c1.,COc1ccc(NC(=O)c2ccc3c(c2)C(=O)N([C@@H](C)c2ccccc2)C3=O)c(OC)c1,amine
34359,Please add a hydroxyl to the molecule C[C@@H](NC(=O)c1cnn(CC(=O)NC2CCCCC2)c1)C(C)(C)C.,C[C@@H](NC(=O)c1cnn(CC(=O)NC2CCCCC2)c1)C(C)(C)C,hydroxyl
74484,Add a nitro to the molecule CNc1ncc(CN(C)C(=O)[C@H]2CC[C@@H]([NH3+])C2)cn1.,CNc1ncc(CN(C)C(=O)[C@H]2CC[C@@H]([NH3+])C2)cn1,nitro
211628,Please add a amide to the molecule COc1ccc(Cl)c(NNC(=O)c2cccc(NC(C)=O)c2)c1.,COc1ccc(Cl)c(NNC(=O)c2cccc(NC(C)=O)c2)c1,amide
229893,Modify the molecule C[C@H]1COC[C@@H](C)N1Cc1cc(Cl)c2c(c1)OCCO2 by adding a amide.,C[C@H]1COC[C@@H](C)N1Cc1cc(Cl)c2c(c1)OCCO2,amide
61135,Please add a amine to the molecule O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12.,O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12,amine
124593,Add a nitrile to the molecule Cc1nc(C[C@@H]2CCC[NH+](Cc3c(C)nc4sccn34)C2)no1.,Cc1nc(C[C@@H]2CCC[NH+](Cc3c(C)nc4sccn34)C2)no1,nitrile
216862,Please add a amide to the molecule CCOC[C@H]1CCCN(C(=O)Cc2csc(NC(=O)C(C)(C)C)n2)C1.,CCOC[C@H]1CCCN(C(=O)Cc2csc(NC(=O)C(C)(C)C)n2)C1,amide
80568,Please add a nitro to the molecule CSCC[C@H](C)NC(=O)NC[C@H](O)c1cc(Cl)cc(Cl)c1.,CSCC[C@H](C)NC(=O)NC[C@H](O)c1cc(Cl)cc(Cl)c1,nitro
176338,Please add a aldehyde to the molecule C=CC(C)(C)c1cc2ccc(OC)c(O)c2oc1=O.,C=CC(C)(C)c1cc2ccc(OC)c(O)c2oc1=O,aldehyde
216385,Please add a amide to the molecule CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2)sc2c1CC[C@H](C)C2.,CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2)sc2c1CC[C@H](C)C2,amide
79190,Please add a halo to the molecule Cc1nn(C)cc1CN1CCOC[C@H]1CC(C)C.,Cc1nn(C)cc1CN1CCOC[C@H]1CC(C)C,halo
164814,Add a amide to the molecule Cc1cc(NC(=O)[C@H](C)Nc2cccc(OCC(F)(F)F)c2)on1.,Cc1cc(NC(=O)[C@H](C)Nc2cccc(OCC(F)(F)F)c2)on1,amide
76389,Add a hydroxyl to the molecule C[C@H](Nc1c[nH+]ccc1N(C)C)c1ccoc1.,C[C@H](Nc1c[nH+]ccc1N(C)C)c1ccoc1,hydroxyl
6903,Please add a aldehyde to the molecule C[C@@H](O)CC(C)(C)CNC(=O)/C=C/c1cccnc1.,C[C@@H](O)CC(C)(C)CNC(=O)/C=C/c1cccnc1,aldehyde
70978,Modify the molecule CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1 by adding a benzene ring.,CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1,benzene ring
37631,Please add a hydroxyl to the molecule C[C@@H]([NH2+]Cc1cccc2cccnc12)c1ccc(Cl)s1.,C[C@@H]([NH2+]Cc1cccc2cccnc12)c1ccc(Cl)s1,hydroxyl
171504,Please add a benzene ring to the molecule O=C(Nc1ccc(F)c(Cl)c1)C1CC[NH+](Cc2ccsc2)CC1.,O=C(Nc1ccc(F)c(Cl)c1)C1CC[NH+](Cc2ccsc2)CC1,benzene ring
88515,Modify the molecule Cc1nc2n(n1)[C@@H](c1ccccc1)C1=C(C[C@H](C)CC1=O)N2 by adding a hydroxyl.,Cc1nc2n(n1)[C@@H](c1ccccc1)C1=C(C[C@H](C)CC1=O)N2,hydroxyl
234016,Please add a amine to the molecule COc1cccc(C(=O)N2CCN(C(=O)c3cc(C)oc3C)CC2)c1OC.,COc1cccc(C(=O)N2CCN(C(=O)c3cc(C)oc3C)CC2)c1OC,amine
85672,Modify the molecule COc1cccc(CN(C)C(=O)N[C@H](C)c2ccc(OC(C)C)cc2)c1 by adding a hydroxyl.,COc1cccc(CN(C)C(=O)N[C@H](C)c2ccc(OC(C)C)cc2)c1,hydroxyl
129979,Add a hydroxyl to the molecule CCc1ccc(N2C(=O)CS[C@@H]2c2cc(OC)ccc2OC)cc1.,CCc1ccc(N2C(=O)CS[C@@H]2c2cc(OC)ccc2OC)cc1,hydroxyl
109957,Modify the molecule CCSC[C@H](C)N(C)C(=O)c1cc(C)nc2ccc(OC)cc12 by adding a benzene ring.,CCSC[C@H](C)N(C)C(=O)c1cc(C)nc2ccc(OC)cc12,benzene ring
154835,Modify the molecule CNC(=O)c1ccc(NC(=O)N[C@H]2CCCc3c2cnn3C)cc1 by adding a hydroxyl.,CNC(=O)c1ccc(NC(=O)N[C@H]2CCCc3c2cnn3C)cc1,hydroxyl
34654,Add a hydroxyl to the molecule Cn1c2c(c(=O)[nH]c1=O)[C@@H](c1ccc(F)cc1)C1=C(N2)c2ccccc2C1=O.,Cn1c2c(c(=O)[nH]c1=O)[C@@H](c1ccc(F)cc1)C1=C(N2)c2ccccc2C1=O,hydroxyl
85853,Add a hydroxyl to the molecule COc1cc(CN2CCN(C(=O)c3ccon3)CC2)cc(OC)c1.,COc1cc(CN2CCN(C(=O)c3ccon3)CC2)cc(OC)c1,hydroxyl
206281,Please add a hydroxyl to the molecule COC(C)(C)CNC(=O)N1CCOC[C@@H]1C1CC1.,COC(C)(C)CNC(=O)N1CCOC[C@@H]1C1CC1,hydroxyl
126614,Modify the molecule Cc1nn(Cc2cccc(Oc3ccccc3)c2)c(C)c1NC(=O)c1ccc2c(c1)OCO2 by adding a benzene ring.,Cc1nn(Cc2cccc(Oc3ccccc3)c2)c(C)c1NC(=O)c1ccc2c(c1)OCO2,benzene ring
30076,Modify the molecule C[C@@H]1[C@@H](C(=O)[O-])CC[NH+]1C1CCC(C(F)(F)F)CC1 by adding a hydroxyl.,C[C@@H]1[C@@H](C(=O)[O-])CC[NH+]1C1CCC(C(F)(F)F)CC1,hydroxyl
8523,Add a halo to the molecule CCC[C@H](O)CNS(=O)(=O)N1CCCCCC1.,CCC[C@H](O)CNS(=O)(=O)N1CCCCCC1,halo
190960,Modify the molecule Cc1nc(CN(C)C(=O)N[C@@H](C)COc2ccccc2F)cs1 by adding a amine.,Cc1nc(CN(C)C(=O)N[C@@H](C)COc2ccccc2F)cs1,amine
165461,Modify the molecule Cc1ccc([C@@H](C)N[C@H](C)c2ccc(C#N)cc2)cc1[N+](=O)[O-] by adding a halo.,Cc1ccc([C@@H](C)N[C@H](C)c2ccc(C#N)cc2)cc1[N+](=O)[O-],halo
238880,Please add a benzene ring to the molecule Cc1ccc(CNC(=O)CN2CCCOC2=O)c(C)c1.,Cc1ccc(CNC(=O)CN2CCCOC2=O)c(C)c1,benzene ring
51503,Add a amide to the molecule CC1=C(C(=O)Nc2cccc(C)c2C)[C@H](c2c(F)cccc2F)NC(=S)N1.,CC1=C(C(=O)Nc2cccc(C)c2C)[C@H](c2c(F)cccc2F)NC(=S)N1,amide
240908,Please add a halo to the molecule COc1cccc(SCC(=O)N[C@H](C)c2nc3ccccc3[nH]2)c1.,COc1cccc(SCC(=O)N[C@H](C)c2nc3ccccc3[nH]2)c1,halo
235997,Modify the molecule CC(=O)Nc1cc(C(F)(F)F)ccc1N(C)C1CCCCC1 by adding a hydroxyl.,CC(=O)Nc1cc(C(F)(F)F)ccc1N(C)C1CCCCC1,hydroxyl
194180,Please add a nitrile to the molecule O=C(CNC(=O)Nc1ccc(-n2cccn2)nc1)Nc1cccnc1.,O=C(CNC(=O)Nc1ccc(-n2cccn2)nc1)Nc1cccnc1,nitrile
3444,Modify the molecule Cc1ccc(S(=O)(=O)N2CCCC[C@@H]2CCNC(=O)Cc2ccc(Cl)cc2)cc1 by adding a hydroxyl.,Cc1ccc(S(=O)(=O)N2CCCC[C@@H]2CCNC(=O)Cc2ccc(Cl)cc2)cc1,hydroxyl
60903,Add a amine to the molecule C[C@H](NC(=O)C(=O)Nc1cccnc1Cl)[C@H]1CN(C)CCO1.,C[C@H](NC(=O)C(=O)Nc1cccnc1Cl)[C@H]1CN(C)CCO1,amine
168884,Please add a halo to the molecule CCc1ccccc1NC(=O)C[NH+](C)CC(=O)Nc1ccccc1.,CCc1ccccc1NC(=O)C[NH+](C)CC(=O)Nc1ccccc1,halo
182397,Please add a halo to the molecule COc1ccc(Cc2nnc(SCC(=O)Nc3cccc(O)c3)n2C)cc1.,COc1ccc(Cc2nnc(SCC(=O)Nc3cccc(O)c3)n2C)cc1,halo
216441,Add a nitrile to the molecule CC[C@H](Br)C(=O)Nc1nc2ccc(C(C)C)cc2s1.,CC[C@H](Br)C(=O)Nc1nc2ccc(C(C)C)cc2s1,nitrile
218656,Add a amine to the molecule CN(C(=O)C1CC1)c1ccccc1C(=O)NNC(=O)Cc1ccc(F)cc1.,CN(C(=O)C1CC1)c1ccccc1C(=O)NNC(=O)Cc1ccc(F)cc1,amine
144817,Modify the molecule COc1ccccc1CN(CCO)C(=O)Nc1cccc(Cl)c1 by adding a nitrile.,COc1ccccc1CN(CCO)C(=O)Nc1cccc(Cl)c1,nitrile
223104,Add a hydroxyl to the molecule Cc1ccc(Br)c(O)c1.,Cc1ccc(Br)c(O)c1,hydroxyl
33939,Modify the molecule COC(=O)C1=C(C)NC(=S)N[C@H]1c1ccc(C)cc1C by adding a amide.,COC(=O)C1=C(C)NC(=S)N[C@H]1c1ccc(C)cc1C,amide
108980,Modify the molecule CN(Cc1cccc(C(N)=O)c1)C(=O)[C@H]1SCCc2ccccc21 by adding a amide.,CN(Cc1cccc(C(N)=O)c1)C(=O)[C@H]1SCCc2ccccc21,amide
49131,Please add a halo to the molecule CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1.,CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1,halo
170567,Add a nitro to the molecule Cc1cc(N2CC[NH+](C)CC2)nc(Cl)c1C#N.,Cc1cc(N2CC[NH+](C)CC2)nc(Cl)c1C#N,nitro
81731,Please add a amide to the molecule C[NH+]1CC[C@@H](Cc2nccnc2C(=O)[O-])C1.,C[NH+]1CC[C@@H](Cc2nccnc2C(=O)[O-])C1,amide
14311,Modify the molecule COc1ccc([C@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C32)cc1COc1ccc(C)cc1 by adding a amide.,COc1ccc([C@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C32)cc1COc1ccc(C)cc1,amide
221710,Add a amide to the molecule CN(Cc1cnn(C)c1)C(=O)Nc1cccc(-c2nnc3n2CCC3)c1.,CN(Cc1cnn(C)c1)C(=O)Nc1cccc(-c2nnc3n2CCC3)c1,amide
19381,Add a amide to the molecule O=C([O-])c1nc2c(F)cccc2s1.,O=C([O-])c1nc2c(F)cccc2s1,amide
147733,Add a amide to the molecule Cc1ncccc1NC(=O)N1CCN(Cc2cccc3ccccc23)CC1.,Cc1ncccc1NC(=O)N1CCN(Cc2cccc3ccccc23)CC1,amide
60498,Add a hydroxyl to the molecule O=C([O-])c1ccc(-n2cccc2)c(F)c1.,O=C([O-])c1ccc(-n2cccc2)c(F)c1,hydroxyl
129981,Please add a hydroxyl to the molecule COC(=O)c1ccc(C[NH+]2CCC(Oc3ccc(C#N)cc3)CC2)cc1F.,COC(=O)c1ccc(C[NH+]2CCC(Oc3ccc(C#N)cc3)CC2)cc1F,hydroxyl
78163,Please add a nitro to the molecule CCc1nc(N2CCOCC2)c2onc(-c3ccc(C)cc3)c2n1.,CCc1nc(N2CCOCC2)c2onc(-c3ccc(C)cc3)c2n1,nitro
153897,Modify the molecule CCOC(=O)c1cccc(NC(=O)[C@@H]2CC[NH2+][C@H]2C)c1 by adding a benzene ring.,CCOC(=O)c1cccc(NC(=O)[C@@H]2CC[NH2+][C@H]2C)c1,benzene ring
115554,Add a hydroxyl to the molecule C[C@H](CNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])CN1CCOCC1.,C[C@H](CNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-])CN1CCOCC1,hydroxyl
16902,Please add a amide to the molecule CS(=O)(=O)[C@H]1CCC[C@@H](Nc2ccc(C#N)cc2[N+](=O)[O-])C1.,CS(=O)(=O)[C@H]1CCC[C@@H](Nc2ccc(C#N)cc2[N+](=O)[O-])C1,amide
3226,Add a aldehyde to the molecule CCCSc1ncc(C[NH+]2CCC(c3cc(=O)[nH]c(-c4ccccn4)n3)CC2)cn1.,CCCSc1ncc(C[NH+]2CCC(c3cc(=O)[nH]c(-c4ccccn4)n3)CC2)cn1,aldehyde
241908,Please add a hydroxyl to the molecule CSc1nnc(SC[C@@H]2CCOCO2)s1.,CSc1nnc(SC[C@@H]2CCOCO2)s1,hydroxyl
133664,Modify the molecule O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1 by adding a aldehyde.,O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1,aldehyde
74949,Add a aldehyde to the molecule CC[C@@H](NS(=O)(=O)c1ccc(CC#N)cc1)c1ccc(Cl)cc1.,CC[C@@H](NS(=O)(=O)c1ccc(CC#N)cc1)c1ccc(Cl)cc1,aldehyde
182556,Please add a benzene ring to the molecule O=C1N[C@H](C2CC2)C(=O)N([C@@H]2CCOC2)c2ccccc21.,O=C1N[C@H](C2CC2)C(=O)N([C@@H]2CCOC2)c2ccccc21,benzene ring
165847,Add a nitro to the molecule CC(C)C[C@H](NC(=O)C=C1C[C@@H]2CC[C@H](C1)[NH+]2C)C(=O)Nc1nccs1.,CC(C)C[C@H](NC(=O)C=C1C[C@@H]2CC[C@H](C1)[NH+]2C)C(=O)Nc1nccs1,nitro
78194,Please add a carboxyl to the molecule BrCCC[C@H]1CCCC[NH+]1Cc1ccccc1.,BrCCC[C@H]1CCCC[NH+]1Cc1ccccc1,carboxyl
212601,Modify the molecule Cc1ccccc1[C@H]1C=NN=C1[C@H]1CCCN(C(=O)CCCc2ccccc2)C1 by adding a nitro.,Cc1ccccc1[C@H]1C=NN=C1[C@H]1CCCN(C(=O)CCCc2ccccc2)C1,nitro
111326,Add a amide to the molecule C[NH+](C1CCSCC1)[C@@H]1CCN(c2ccccc2)C1=O.,C[NH+](C1CCSCC1)[C@@H]1CCN(c2ccccc2)C1=O,amide
89233,Please add a benzene ring to the molecule C[C@@H](c1cc2ccccc2o1)N(C)C(=O)CN(C)Cc1ccc(C#N)cc1.,C[C@@H](c1cc2ccccc2o1)N(C)C(=O)CN(C)Cc1ccc(C#N)cc1,benzene ring
10567,Modify the molecule O=CC1=CCC[C@@H]([N+](=O)[O-])C1 by adding a nitro.,O=CC1=CCC[C@@H]([N+](=O)[O-])C1,nitro
144315,Modify the molecule Cc1cc(C(=O)C[NH+]2CCC[C@@H]2c2cccs2)c(C)n1-c1c(C)n(C)n(-c2ccccc2)c1=O by adding a amide.,Cc1cc(C(=O)C[NH+]2CCC[C@@H]2c2cccs2)c(C)n1-c1c(C)n(C)n(-c2ccccc2)c1=O,amide
168300,Add a benzene ring to the molecule COc1cccc(CNC(=O)Nc2cc(C)cc3cccnc23)n1.,COc1cccc(CNC(=O)Nc2cc(C)cc3cccnc23)n1,benzene ring
221018,Modify the molecule Cn1nccc1CNC(=O)Cc1noc2ccccc12 by adding a halo.,Cn1nccc1CNC(=O)Cc1noc2ccccc12,halo
62336,Add a hydroxyl to the molecule Cc1nc(C)c(C(=O)N(C)[C@@H]2CCC[C@@H](C)C2)o1.,Cc1nc(C)c(C(=O)N(C)[C@@H]2CCC[C@@H](C)C2)o1,hydroxyl
112200,Modify the molecule CN(C[C@@H]1CCOC1)C(=O)Nc1cnn(C[C@H]2CCCO2)c1 by adding a benzene ring.,CN(C[C@@H]1CCOC1)C(=O)Nc1cnn(C[C@H]2CCCO2)c1,benzene ring
50920,Add a nitrile to the molecule CCCc1cc(NC(=O)C(=O)N[C@@H]2CCC[C@H]2c2ccc(F)cc2)n(C)n1.,CCCc1cc(NC(=O)C(=O)N[C@@H]2CCC[C@H]2c2ccc(F)cc2)n(C)n1,nitrile
222111,Add a thiol to the molecule CCC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]([NH+](C)[C@@H](C)C2CC2)C1.,CCC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]([NH+](C)[C@@H](C)C2CC2)C1,thiol
28583,Add a amide to the molecule CC1(C)[C@H]2CC[C@]1(C)C(=O)[C@@H]2COC(=O)c1ccccc1.,CC1(C)[C@H]2CC[C@]1(C)C(=O)[C@@H]2COC(=O)c1ccccc1,amide
220107,Add a amide to the molecule CCOCCN(C)C(=O)c1oc2c(OC)cccc2c1C.,CCOCCN(C)C(=O)c1oc2c(OC)cccc2c1C,amide
81501,Modify the molecule CCN(CC)C(=O)[C@@H]1CCC[NH+](Cc2nc(-c3cccs3)oc2C)C1 by adding a hydroxyl.,CCN(CC)C(=O)[C@@H]1CCC[NH+](Cc2nc(-c3cccs3)oc2C)C1,hydroxyl
89821,Add a hydroxyl to the molecule CC(C)Oc1ncccc1CNC(=O)c1cnccn1.,CC(C)Oc1ncccc1CNC(=O)c1cnccn1,hydroxyl
162376,Please add a carboxyl to the molecule CCCN(Cc1cccnc1)C(=O)c1sccc1C.,CCCN(Cc1cccnc1)C(=O)c1sccc1C,carboxyl
223018,Add a amide to the molecule Cn1nnnc1-c1cccc(NC(=O)CCS(=O)(=O)c2ccc(Cl)cc2)c1.,Cn1nnnc1-c1cccc(NC(=O)CCS(=O)(=O)c2ccc(Cl)cc2)c1,amide
185492,Please add a amide to the molecule Clc1ccc([C@@H](Cl)[C@H]2COCCO2)c2ccccc12.,Clc1ccc([C@@H](Cl)[C@H]2COCCO2)c2ccccc12,amide
241356,Add a hydroxyl to the molecule CCC[NH2+][C@H](Cc1ccncc1)[C@H]1CSCCO1.,CCC[NH2+][C@H](Cc1ccncc1)[C@H]1CSCCO1,hydroxyl
129847,Modify the molecule CC(C)(C)N1C[C@H](C(=O)N2CCC(C(=O)Nc3cccc(F)c3)CC2)CC1=O by adding a benzene ring.,CC(C)(C)N1C[C@H](C(=O)N2CCC(C(=O)Nc3cccc(F)c3)CC2)CC1=O,benzene ring
17632,Please add a aldehyde to the molecule CC(C)NC(=O)CCN1C(=O)[C@H](C)SC1=S.,CC(C)NC(=O)CCN1C(=O)[C@H](C)SC1=S,aldehyde
155806,Modify the molecule C[C@@H]1CCC[C@]([NH3+])(c2nc([C@]3(C)CCCO3)no2)C1 by adding a amide.,C[C@@H]1CCC[C@]([NH3+])(c2nc([C@]3(C)CCCO3)no2)C1,amide
48693,Please add a benzene ring to the molecule CC(C)(C)C(=O)/C=C\c1ccncc1.,CC(C)(C)C(=O)/C=C\c1ccncc1,benzene ring
69431,Please add a hydroxyl to the molecule CCOc1ncccc1C(=O)O[C@@H]1CCC[C@H](C(F)(F)F)C1.,CCOc1ncccc1C(=O)O[C@@H]1CCC[C@H](C(F)(F)F)C1,hydroxyl
37111,Modify the molecule O=C(C[C@H]1SCCNC1=O)Nc1cc(Cl)cc(Cl)c1 by adding a aldehyde.,O=C(C[C@H]1SCCNC1=O)Nc1cc(Cl)cc(Cl)c1,aldehyde
133377,Add a benzene ring to the molecule CS(=O)(=O)NC1CCN(C(=O)CCCSc2ccccc2)CC1.,CS(=O)(=O)NC1CCN(C(=O)CCCSc2ccccc2)CC1,benzene ring
183641,Add a carboxyl to the molecule Cc1ccc(CNC(=O)NC[C@@H]2CC[C@@H](C(=O)[O-])O2)cn1.,Cc1ccc(CNC(=O)NC[C@@H]2CC[C@@H](C(=O)[O-])O2)cn1,carboxyl
199136,Modify the molecule CCCN1C(=O)CCc2cc(NC(=O)c3cscc3C)ccc21 by adding a carboxyl.,CCCN1C(=O)CCc2cc(NC(=O)c3cscc3C)ccc21,carboxyl
9912,Add a nitro to the molecule CCOC(=O)c1cn[nH]c1S(=O)(=O)NCc1ccco1.,CCOC(=O)c1cn[nH]c1S(=O)(=O)NCc1ccco1,nitro
156638,Modify the molecule CN(C(=O)CCCC[NH3+])C1CCC(C)(C)CC1 by adding a aldehyde.,CN(C(=O)CCCC[NH3+])C1CCC(C)(C)CC1,aldehyde
145337,Add a thiol to the molecule CCOc1ccc(F)c(C(=O)NCC(=O)N(C)C)c1F.,CCOc1ccc(F)c(C(=O)NCC(=O)N(C)C)c1F,thiol
149688,Modify the molecule Cc1ccc(C)c([C@H]2CCN(C(=O)OC(C)(C)C)CC2=O)c1 by adding a halo.,Cc1ccc(C)c([C@H]2CCN(C(=O)OC(C)(C)C)CC2=O)c1,halo
40389,Modify the molecule O=C(N[C@@H]1CCOC1)c1ccc(S(=O)(=O)N2CCC(CO)CC2)cc1 by adding a amide.,O=C(N[C@@H]1CCOC1)c1ccc(S(=O)(=O)N2CCC(CO)CC2)cc1,amide
157277,Please add a nitro to the molecule Cc1ccc(C)c(Nc2nc(C)nc3sc4c(c23)CCC4)c1.,Cc1ccc(C)c(Nc2nc(C)nc3sc4c(c23)CCC4)c1,nitro
43501,Modify the molecule CCn1cc[nH+]c(N2CCO[C@H](c3cccc(O)c3)C2)c1=O by adding a aldehyde.,CCn1cc[nH+]c(N2CCO[C@H](c3cccc(O)c3)C2)c1=O,aldehyde
156669,Please add a amide to the molecule Cc1cc(CN(C)C(=O)[C@@H]2[C@@H]3C=C[C@@]4(CN(Cc5ccc(C)c(C)c5)C(=O)[C@H]24)O3)on1.,Cc1cc(CN(C)C(=O)[C@@H]2[C@@H]3C=C[C@@]4(CN(Cc5ccc(C)c(C)c5)C(=O)[C@H]24)O3)on1,amide
152030,Add a halo to the molecule Cc1csc(SCc2ccc(C(=O)Nc3nc4ccccc4[nH]3)cc2)n1.,Cc1csc(SCc2ccc(C(=O)Nc3nc4ccccc4[nH]3)cc2)n1,halo
30468,Please add a nitro to the molecule COc1ccc([C@H]2N=C(CS[C@@H]3N=NC(=O)c4cc(-c5cccs5)nn43)[C@H](C)O2)c(OC)c1.,COc1ccc([C@H]2N=C(CS[C@@H]3N=NC(=O)c4cc(-c5cccs5)nn43)[C@H](C)O2)c(OC)c1,nitro
238900,Modify the molecule CC1(C(=O)N2CCC[C@@H]3CCC[C@@H]32)CCCC1 by adding a amide.,CC1(C(=O)N2CCC[C@@H]3CCC[C@@H]32)CCCC1,amide
21265,Add a aldehyde to the molecule CC(C)OCCS(=O)(=O)NCc1ccccc1C#CCO.,CC(C)OCCS(=O)(=O)NCc1ccccc1C#CCO,aldehyde
213906,Add a benzene ring to the molecule CN1C(=O)c2cc(C(=O)NCCC3=c4ccccc4=[NH+]C3)nn2C[C@@]1(C)C(=O)NC1CCCCC1.,CN1C(=O)c2cc(C(=O)NCCC3=c4ccccc4=[NH+]C3)nn2C[C@@]1(C)C(=O)NC1CCCCC1,benzene ring
239004,Please add a hydroxyl to the molecule Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCC[C@@H]3O)cc2F)n1.,Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCC[C@@H]3O)cc2F)n1,hydroxyl
236210,Modify the molecule COc1c(C)cnc(COc2cccc(N)c2C)c1C by adding a amide.,COc1c(C)cnc(COc2cccc(N)c2C)c1C,amide
112868,Modify the molecule N#Cc1ccc(Cl)c(NC(=O)C(=O)N2CC[C@@H](O)C2)c1 by adding a benzene ring.,N#Cc1ccc(Cl)c(NC(=O)C(=O)N2CC[C@@H](O)C2)c1,benzene ring
67957,Please add a carboxyl to the molecule NC(=O)c1cc(NC(=O)[C@@H]2CC=CCC2)ccc1Cl.,NC(=O)c1cc(NC(=O)[C@@H]2CC=CCC2)ccc1Cl,carboxyl
89799,Please add a carboxyl to the molecule CC(C)(CC(=O)N1CCc2ccccc2C1)CC1=Nc2ccccc2S(=O)(=O)N1.,CC(C)(CC(=O)N1CCc2ccccc2C1)CC1=Nc2ccccc2S(=O)(=O)N1,carboxyl
131048,Modify the molecule C[NH2+][C@H](Cc1ccccc1)c1cc(C(F)(F)F)ccc1F by adding a hydroxyl.,C[NH2+][C@H](Cc1ccccc1)c1cc(C(F)(F)F)ccc1F,hydroxyl
153066,Modify the molecule CC(C)N(C(=O)c1ccc(Br)s1)C(C)C by adding a hydroxyl.,CC(C)N(C(=O)c1ccc(Br)s1)C(C)C,hydroxyl
108759,Please add a benzene ring to the molecule O=C(Nc1cnn(CCc2ccccc2)c1)c1ccc(F)cc1F.,O=C(Nc1cnn(CCc2ccccc2)c1)c1ccc(F)cc1F,benzene ring
58405,Add a benzene ring to the molecule NC1=C[C@@H](C(=O)N2CCN(C(=O)c3ccccc3)CC2)N=[NH+]1.,NC1=C[C@@H](C(=O)N2CCN(C(=O)c3ccccc3)CC2)N=[NH+]1,benzene ring
63111,Modify the molecule O=C(NCCCCOc1ccc(F)cc1)N1CCCCCC1 by adding a hydroxyl.,O=C(NCCCCOc1ccc(F)cc1)N1CCCCCC1,hydroxyl
75174,Please add a nitro to the molecule O=C(c1ccc([O-])nn1)N1CCN(Cc2ccncc2)CC1.,O=C(c1ccc([O-])nn1)N1CCN(Cc2ccncc2)CC1,nitro
184206,Add a benzene ring to the molecule COC(=O)CCC(=O)NC(C)(C)c1cccc(F)c1.,COC(=O)CCC(=O)NC(C)(C)c1cccc(F)c1,benzene ring
246923,Please add a aldehyde to the molecule Cc1nc(-c2cccc(C(=O)N[C@H]3C[C@H]3c3c(F)cccc3F)c2)n[nH]1.,Cc1nc(-c2cccc(C(=O)N[C@H]3C[C@H]3c3c(F)cccc3F)c2)n[nH]1,aldehyde
50249,Please add a carboxyl to the molecule CCc1ncc(CN[C@@H](C)[C@@H](O)c2ccc(F)cc2)s1.,CCc1ncc(CN[C@@H](C)[C@@H](O)c2ccc(F)cc2)s1,carboxyl
188931,Modify the molecule O=C([O-])c1cc(S(=O)(=O)[N-]c2ccccc2-n2cc(Br)cn2)c[nH]1 by adding a nitro.,O=C([O-])c1cc(S(=O)(=O)[N-]c2ccccc2-n2cc(Br)cn2)c[nH]1,nitro
28929,Modify the molecule Cc1nnc(Sc2nc(C3CC3)n(-c3ccccc3)n2)c2ccccc12 by adding a aldehyde.,Cc1nnc(Sc2nc(C3CC3)n(-c3ccccc3)n2)c2ccccc12,aldehyde
245761,Modify the molecule O=C(c1cn(Cc2ccccc2F)nn1)N1CCC(O)(c2ccccc2)CC1 by adding a carboxyl.,O=C(c1cn(Cc2ccccc2F)nn1)N1CCC(O)(c2ccccc2)CC1,carboxyl
124354,Modify the molecule CNC(=O)C1CC[NH+](C[C@@H](O)Cn2cnc3cc(C)c(C)cc32)CC1 by adding a amine.,CNC(=O)C1CC[NH+](C[C@@H](O)Cn2cnc3cc(C)c(C)cc32)CC1,amine
228113,Add a nitro to the molecule CC(C)[C@H](C)[NH2+][C@@H](C)c1nc(Cc2ccccc2)no1.,CC(C)[C@H](C)[NH2+][C@@H](C)c1nc(Cc2ccccc2)no1,nitro
33723,Please add a benzene ring to the molecule O=C(Nc1ccccc1)c1ccc(C(=O)N2CCOC[C@@H]2CCO)cc1.,O=C(Nc1ccccc1)c1ccc(C(=O)N2CCOC[C@@H]2CCO)cc1,benzene ring
168270,Modify the molecule CCOC[C@@H]1CC[NH+](Cc2cc(C#N)n(C)c2C)C1 by adding a aldehyde.,CCOC[C@@H]1CC[NH+](Cc2cc(C#N)n(C)c2C)C1,aldehyde
110242,Add a amine to the molecule Cc1cc([C@@H](C)NC(=O)C(=O)Nc2ccc3[nH]ccc3c2)c(C)s1.,Cc1cc([C@@H](C)NC(=O)C(=O)Nc2ccc3[nH]ccc3c2)c(C)s1,amine
94750,Add a aldehyde to the molecule CC(C)Cc1noc(C[NH+](Cc2cccc(Cl)c2)C(C)C)n1.,CC(C)Cc1noc(C[NH+](Cc2cccc(Cl)c2)C(C)C)n1,aldehyde
118123,Add a hydroxyl to the molecule CNC(=O)NC(=O)[C@H](N[C@@H](C)c1cc(C)ccc1OC)c1ccccc1.,CNC(=O)NC(=O)[C@H](N[C@@H](C)c1cc(C)ccc1OC)c1ccccc1,hydroxyl
81953,Modify the molecule CSCCN(C)C(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1 by adding a amide.,CSCCN(C)C(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1,amide
8465,Modify the molecule CC1CCN(C(=O)c2csc(C(C)C)c2)CC1 by adding a hydroxyl.,CC1CCN(C(=O)c2csc(C(C)C)c2)CC1,hydroxyl
34931,Please add a hydroxyl to the molecule CN(C)c1ccccc1NC(=O)CCSc1ccc(F)cc1.,CN(C)c1ccccc1NC(=O)CCSc1ccc(F)cc1,hydroxyl
180116,Modify the molecule Cc1ccc(C(=O)N2CCC[C@H](CCc3ccccc3F)C2)cc1O by adding a halo.,Cc1ccc(C(=O)N2CCC[C@H](CCc3ccccc3F)C2)cc1O,halo
169236,Add a amide to the molecule CCOC(=O)CCc1c(C)[nH]c2c(C(=O)Nc3cc(Cl)ccc3C)cnn2c1=O.,CCOC(=O)CCc1c(C)[nH]c2c(C(=O)Nc3cc(Cl)ccc3C)cnn2c1=O,amide
88172,Please add a benzene ring to the molecule CN(C[C@H]1CCC[NH2+]C1)c1ncc(Cl)cn1.,CN(C[C@H]1CCC[NH2+]C1)c1ncc(Cl)cn1,benzene ring
286,Add a amide to the molecule O=C1N=C(N2CCCCC2)S/C1=C1/C(=O)Nc2ccccc21.,O=C1N=C(N2CCCCC2)S/C1=C1/C(=O)Nc2ccccc21,amide
156373,Add a amide to the molecule C[C@@H]1NC(=O)/C(=C/c2ccccc2Cl)NC1=O.,C[C@@H]1NC(=O)/C(=C/c2ccccc2Cl)NC1=O,amide
215583,Add a hydroxyl to the molecule CNC(=O)CCCn1cc(C(=O)[O-])cc1Br.,CNC(=O)CCCn1cc(C(=O)[O-])cc1Br,hydroxyl
26967,Add a benzene ring to the molecule O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1.,O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1,benzene ring
226415,Add a benzene ring to the molecule C[C@H](NC1CC[NH+]([C@H](C)c2ccncc2)CC1)c1ccc(F)cc1Cl.,C[C@H](NC1CC[NH+]([C@H](C)c2ccncc2)CC1)c1ccc(F)cc1Cl,benzene ring
134666,Please add a carboxyl to the molecule Cn1ncc(C(=O)Nc2cccc(-c3ncc[nH]3)c2)c1-n1cccc1.,Cn1ncc(C(=O)Nc2cccc(-c3ncc[nH]3)c2)c1-n1cccc1,carboxyl
96940,Add a halo to the molecule CN(CCC#N)Cc1ccccc1OCC(F)(F)F.,CN(CCC#N)Cc1ccccc1OCC(F)(F)F,halo
145154,Modify the molecule Cn1c(SCC(=O)N2CC[NH+](Cc3ccccc3)CC2)nnc1-c1cccc([N+](=O)[O-])c1 by adding a benzene ring.,Cn1c(SCC(=O)N2CC[NH+](Cc3ccccc3)CC2)nnc1-c1cccc([N+](=O)[O-])c1,benzene ring
142943,Please add a aldehyde to the molecule CCCc1cc(NC(=O)Cc2csc(Cc3ccccc3)n2)n(C)n1.,CCCc1cc(NC(=O)Cc2csc(Cc3ccccc3)n2)n(C)n1,aldehyde
189874,Add a benzene ring to the molecule O=C(c1ccccc1O)N1CCN(S(=O)(=O)c2ccc(F)c(F)c2)CC1.,O=C(c1ccccc1O)N1CCN(S(=O)(=O)c2ccc(F)c(F)c2)CC1,benzene ring
86031,Please add a benzene ring to the molecule O=C(NCc1cccnc1)[C@@H]1CCC[NH+](C2CCN(Cc3nccs3)CC2)C1.,O=C(NCc1cccnc1)[C@@H]1CCC[NH+](C2CCN(Cc3nccs3)CC2)C1,benzene ring
35837,Please add a hydroxyl to the molecule CNS(=O)(=O)c1cc(C(=O)NCc2cccs2)c(C)o1.,CNS(=O)(=O)c1cc(C(=O)NCc2cccs2)c(C)o1,hydroxyl
7301,Add a hydroxyl to the molecule CC[C@@H](NC(=O)Cc1c[nH]c2cc(Cl)ccc12)C(=O)N1CCOCC1.,CC[C@@H](NC(=O)Cc1c[nH]c2cc(Cl)ccc12)C(=O)N1CCOCC1,hydroxyl
132874,Add a nitro to the molecule CCCC[C@H]1CCC[C@@H]1NC(=O)NCc1ccc(N2CCO[C@H](C)C2)[nH+]c1.,CCCC[C@H]1CCC[C@@H]1NC(=O)NCc1ccc(N2CCO[C@H](C)C2)[nH+]c1,nitro
69412,Add a hydroxyl to the molecule CC[C@H](C)n1ncc(C(=O)NCc2ccc(C)s2)c1C1CC1.,CC[C@H](C)n1ncc(C(=O)NCc2ccc(C)s2)c1C1CC1,hydroxyl
81865,Modify the molecule O=C([O-])C[C@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(c1)OCO2 by adding a amide.,O=C([O-])C[C@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(c1)OCO2,amide
145546,Modify the molecule CN(C)C(=O)N(CCC[NH3+])C1CCCCC1 by adding a carboxyl.,CN(C)C(=O)N(CCC[NH3+])C1CCCCC1,carboxyl
28446,Please add a nitro to the molecule Cn1nc([C@H]2CCC[NH2+]C2)c2nccnc21.,Cn1nc([C@H]2CCC[NH2+]C2)c2nccnc21,nitro
61316,Please add a hydroxyl to the molecule C[C@H]1C[NH+](Cc2ccc(C[NH2+]C(C)(C)C)cn2)C[C@@H]1C.,C[C@H]1C[NH+](Cc2ccc(C[NH2+]C(C)(C)C)cn2)C[C@@H]1C,hydroxyl
19442,Add a hydroxyl to the molecule CC[C@@H]1CCC(=O)[C@@H](CCc2ccc3c(c2)CCO3)C1.,CC[C@@H]1CCC(=O)[C@@H](CCc2ccc3c(c2)CCO3)C1,hydroxyl
223191,Modify the molecule CC(C)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)Nc1nc(-c2cccnc2)cs1 by adding a hydroxyl.,CC(C)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)Nc1nc(-c2cccnc2)cs1,hydroxyl
81515,Please add a benzene ring to the molecule CO[C@@H]1C(=O)C(C(C)=O)=C(O)[C@]2(O)C(=O)c3c(cc4cccc(O)c4c3O)C[C@@H]12.,CO[C@@H]1C(=O)C(C(C)=O)=C(O)[C@]2(O)C(=O)c3c(cc4cccc(O)c4c3O)C[C@@H]12,benzene ring
143634,Modify the molecule CCN(CC)S(=O)(=O)c1ccc(OC)c(C(=O)N2CCC3(CCCCC3)CC2)c1 by adding a carboxyl.,CCN(CC)S(=O)(=O)c1ccc(OC)c(C(=O)N2CCC3(CCCCC3)CC2)c1,carboxyl
235512,Modify the molecule Cn1c(C(=O)N2CC[NH+](C(c3ccccc3)c3ccccc3)CC2)cc2sccc21 by adding a benzene ring.,Cn1c(C(=O)N2CC[NH+](C(c3ccccc3)c3ccccc3)CC2)cc2sccc21,benzene ring
245703,Please add a amine to the molecule CCS[C@@H]1CC[C@@H](NC(=O)NC2(c3nccs3)CCCC2)C1.,CCS[C@@H]1CC[C@@H](NC(=O)NC2(c3nccs3)CCCC2)C1,amine
75126,Modify the molecule CC(C)C(=O)N1CCN(CCS(C)(=O)=O)CC1 by adding a hydroxyl.,CC(C)C(=O)N1CCN(CCS(C)(=O)=O)CC1,hydroxyl
51709,Please add a amide to the molecule COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1.,COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1,amide
190360,Modify the molecule Cc1ccc(C)c(NC(=O)c2[nH]c(C)c(C(=O)OC(C)C)c2C)c1 by adding a amide.,Cc1ccc(C)c(NC(=O)c2[nH]c(C)c(C(=O)OC(C)C)c2C)c1,amide
113303,Add a benzene ring to the molecule O=C(NCCCn1cccn1)NCC1CCCCCCC1.,O=C(NCCCn1cccn1)NCC1CCCCCCC1,benzene ring
95679,Modify the molecule Cc1c(N)nc(-c2ncc[nH]2)[nH]c1=O by adding a benzene ring.,Cc1c(N)nc(-c2ncc[nH]2)[nH]c1=O,benzene ring
148375,Please add a benzene ring to the molecule CC(C)c1n[nH]c(SCC(=O)c2c[nH]c3ccccc23)n1.,CC(C)c1n[nH]c(SCC(=O)c2c[nH]c3ccccc23)n1,benzene ring
183041,Modify the molecule Cc1cc(C(=O)N/N=C/c2ccc(C)s2)[nH]n1 by adding a hydroxyl.,Cc1cc(C(=O)N/N=C/c2ccc(C)s2)[nH]n1,hydroxyl
13597,Please add a hydroxyl to the molecule Cc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21.,Cc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21,hydroxyl
169763,Please add a benzene ring to the molecule O=C(Cc1ccc(F)c(F)c1)N[C@H]1CCSc2ccc(F)cc21.,O=C(Cc1ccc(F)c(F)c1)N[C@H]1CCSc2ccc(F)cc21,benzene ring
152834,Add a amine to the molecule CC(C)C[C@H]1Nc2ccc(C(=O)NCC[NH+]3CCCCCC3)cc2NC1=O.,CC(C)C[C@H]1Nc2ccc(C(=O)NCC[NH+]3CCCCCC3)cc2NC1=O,amine
49354,Add a hydroxyl to the molecule c1ccc([C@H]([NH2+]Cc2cccnc2)c2ccccn2)cc1.,c1ccc([C@H]([NH2+]Cc2cccnc2)c2ccccn2)cc1,hydroxyl
145639,Modify the molecule O=[N+]([O-])c1ccccc1/C=N/Nc1nncc(-c2ccccc2)n1 by adding a amine.,O=[N+]([O-])c1ccccc1/C=N/Nc1nncc(-c2ccccc2)n1,amine
212738,Modify the molecule C[C@@H]1OCC[C@@H]1C(=O)N[C@@H]1CCN(CC(F)(F)F)C1 by adding a halo.,C[C@@H]1OCC[C@@H]1C(=O)N[C@@H]1CCN(CC(F)(F)F)C1,halo
234176,Modify the molecule CC(NCCC(C)C)=C1C(=O)N(C)C(=O)N(C)C1=O by adding a benzene ring.,CC(NCCC(C)C)=C1C(=O)N(C)C(=O)N(C)C1=O,benzene ring
230695,Please add a carboxyl to the molecule CC(=O)c1ccccc1S(=O)(=O)N1CCC(C(=O)[O-])CC1.,CC(=O)c1ccccc1S(=O)(=O)N1CCC(C(=O)[O-])CC1,carboxyl
74283,Modify the molecule Cc1[nH]c2ccccc2c1CC(=O)N[C@H](CO)Cc1c[nH]c2ccccc12 by adding a aldehyde.,Cc1[nH]c2ccccc2c1CC(=O)N[C@H](CO)Cc1c[nH]c2ccccc12,aldehyde
170837,Please add a amide to the molecule C[NH2+][C@H](C)C(C)(C)C[NH+](C)CCc1ccccc1.,C[NH2+][C@H](C)C(C)(C)C[NH+](C)CCc1ccccc1,amide
249234,Add a hydroxyl to the molecule COC(=O)C(C)(C)C[NH+](C)C[C@H]1CCCO1.,COC(=O)C(C)(C)C[NH+](C)C[C@H]1CCCO1,hydroxyl
225901,Please add a amide to the molecule C=C[C@H](O)[C@@H](F)C(=O)OCC.,C=C[C@H](O)[C@@H](F)C(=O)OCC,amide
209026,Add a amine to the molecule Cc1ccc([C@@H](C)N[C@@H](C)C(=O)N(C(C)C)C(C)C)cc1.,Cc1ccc([C@@H](C)N[C@@H](C)C(=O)N(C(C)C)C(C)C)cc1,amine
74089,Modify the molecule C[C@H]1C[C@H]([C@]2(O)CCCCC2(C)C)CC[C@H]1C by adding a amine.,C[C@H]1C[C@H]([C@]2(O)CCCCC2(C)C)CC[C@H]1C,amine
146811,Modify the molecule CCCN(C(=O)Cc1c(C(=O)[O-])c(C)cn1CC)c1cccc(Cl)c1 by adding a carboxyl.,CCCN(C(=O)Cc1c(C(=O)[O-])c(C)cn1CC)c1cccc(Cl)c1,carboxyl
24853,Add a benzene ring to the molecule Cc1csc(CC[NH2+]C[C@@H]2C=C[C@@H]([NH3+])C2)n1.,Cc1csc(CC[NH2+]C[C@@H]2C=C[C@@H]([NH3+])C2)n1,benzene ring
25587,Please add a aldehyde to the molecule Cc1ccc(Cl)cc1N1CCN(C(=O)c2ccc3c(c2)OCO3)[C@H](C)C1=O.,Cc1ccc(Cl)cc1N1CCN(C(=O)c2ccc3c(c2)OCO3)[C@H](C)C1=O,aldehyde
137991,Please add a hydroxyl to the molecule COc1cc2c(C(=O)Nc3ccc(F)cc3F)cn(CC(C)C)c(=O)c2cc1OC.,COc1cc2c(C(=O)Nc3ccc(F)cc3F)cn(CC(C)C)c(=O)c2cc1OC,hydroxyl
64889,Add a amine to the molecule CN[C@]1(C(=O)OC)CCC[C@@H]1CCn1cc(Cl)c(C)n1.,CN[C@]1(C(=O)OC)CCC[C@@H]1CCn1cc(Cl)c(C)n1,amine
977,Add a halo to the molecule COc1cc([C@H]2C(C(=O)Nc3ccccn3)=C(C)NC3=C2C(=O)CCC3)ccc1OCc1ccccc1.,COc1cc([C@H]2C(C(=O)Nc3ccccn3)=C(C)NC3=C2C(=O)CCC3)ccc1OCc1ccccc1,halo
235910,Please add a aldehyde to the molecule CC(=O)c1ccc(CC(N)=O)s1.,CC(=O)c1ccc(CC(N)=O)s1,aldehyde
176935,Add a amine to the molecule CC[C@@](C)([N+](=O)[O-])[C@@](C)(CC)[N+](=O)[O-].,CC[C@@](C)([N+](=O)[O-])[C@@](C)(CC)[N+](=O)[O-],amine
52000,Please add a hydroxyl to the molecule Cc1nn(C)cc1[C@H](C)NS(=O)(=O)N(C)C(C)C.,Cc1nn(C)cc1[C@H](C)NS(=O)(=O)N(C)C(C)C,hydroxyl
106914,Modify the molecule NC(=O)c1cccc(CCNc2cc(-n3cccn3)nc(N)n2)c1 by adding a benzene ring.,NC(=O)c1cccc(CCNc2cc(-n3cccn3)nc(N)n2)c1,benzene ring
88690,Modify the molecule Cc1cc(F)ccc1C(=O)OCc1nncn1C1CC1 by adding a hydroxyl.,Cc1cc(F)ccc1C(=O)OCc1nncn1C1CC1,hydroxyl
210746,Modify the molecule COc1cccc(C[NH2+]Cc2ccc(Br)c(C)c2)c1 by adding a nitro.,COc1cccc(C[NH2+]Cc2ccc(Br)c(C)c2)c1,nitro
26129,Add a thiol to the molecule C[NH+]1CCN(CCC(=O)N2CCC3=c4ccccc4=[NH+][C@H]3[C@H]2c2cc(F)ccc2F)CC1.,C[NH+]1CCN(CCC(=O)N2CCC3=c4ccccc4=[NH+][C@H]3[C@H]2c2cc(F)ccc2F)CC1,thiol
67331,Add a benzene ring to the molecule C[C@@H]1OCC[C@@H]1C(=O)NCCCC(C)(C)C.,C[C@@H]1OCC[C@@H]1C(=O)NCCCC(C)(C)C,benzene ring
206191,Please add a hydroxyl to the molecule COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1.,COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1,hydroxyl
90153,Add a amide to the molecule O=C(NCc1nccc2ccccc12)c1cnn(-c2cccc(Cl)c2)c1.,O=C(NCc1nccc2ccccc12)c1cnn(-c2cccc(Cl)c2)c1,amide
174674,Please add a benzene ring to the molecule CC(=O)Nc1ccc([C@@H](O)C[NH+]2CCC3(CC2)C[C@@H](O)c2ccc4ccccc4c2O3)cc1.,CC(=O)Nc1ccc([C@@H](O)C[NH+]2CCC3(CC2)C[C@@H](O)c2ccc4ccccc4c2O3)cc1,benzene ring
89288,Please add a hydroxyl to the molecule CCOC(=O)C(C)(C)NC(=O)c1cc(Br)cn1C.,CCOC(=O)C(C)(C)NC(=O)c1cc(Br)cn1C,hydroxyl
215506,Add a nitro to the molecule Cc1ccccc1[C@@H]1CC(c2ccccc2NS(C)(=O)=O)=NN1C(=O)C(C)C.,Cc1ccccc1[C@@H]1CC(c2ccccc2NS(C)(=O)=O)=NN1C(=O)C(C)C,nitro
239209,Modify the molecule Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1 by adding a carboxyl.,Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1,carboxyl
16756,Please add a nitro to the molecule C=CCOc1cccc([C@@H]2c3c(-c4cc(C)cc(C)c4O)n[nH]c3C(=O)N2Cc2ccco2)c1.,C=CCOc1cccc([C@@H]2c3c(-c4cc(C)cc(C)c4O)n[nH]c3C(=O)N2Cc2ccco2)c1,nitro
192295,Modify the molecule [NH3+]CCc1n[nH]c(-c2cccnc2)n1 by adding a amide.,[NH3+]CCc1n[nH]c(-c2cccnc2)n1,amide
210508,Modify the molecule CN(C)/C=N\C(=O)c1cc(C(=O)c2ccc(C(C)(C)C)cc2)c[nH]1 by adding a nitro.,CN(C)/C=N\C(=O)c1cc(C(=O)c2ccc(C(C)(C)C)cc2)c[nH]1,nitro
184620,Add a amide to the molecule Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)c1cccc(N(C)C)c1.,Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)c1cccc(N(C)C)c1,amide
198425,Please add a aldehyde to the molecule CC[NH+](CC(=O)Nc1c(C)cc(C)cc1Cl)[C@H](C)c1cccc(O)c1.,CC[NH+](CC(=O)Nc1c(C)cc(C)cc1Cl)[C@H](C)c1cccc(O)c1,aldehyde
10059,Modify the molecule CC(C)(O)CC[NH+]1CCC[C@H]1C1CC[NH2+]CC1 by adding a amide.,CC(C)(O)CC[NH+]1CCC[C@H]1C1CC[NH2+]CC1,amide
9666,Modify the molecule C[C@H](Oc1ccc(F)c(F)c1)C(=O)OCCc1cccnc1 by adding a hydroxyl.,C[C@H](Oc1ccc(F)c(F)c1)C(=O)OCCc1cccnc1,hydroxyl
187415,Modify the molecule Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F by adding a halo.,Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F,halo
131387,Add a benzene ring to the molecule CN1CCc2cc(C[NH2+]C3CCN(c4ccc(C(=O)NCc5ccc6c(c5)OCO6)cc4)CC3)ccc21.,CN1CCc2cc(C[NH2+]C3CCN(c4ccc(C(=O)NCc5ccc6c(c5)OCO6)cc4)CC3)ccc21,benzene ring
183022,Please add a benzene ring to the molecule CCOC(=O)C(=O)N1CCN(c2cnc3ccccc3n2)CC1.,CCOC(=O)C(=O)N1CCN(c2cnc3ccccc3n2)CC1,benzene ring
141332,Please add a amide to the molecule C=C(C)C(=O)[C@H]1CCOc2ccccc21.,C=C(C)C(=O)[C@H]1CCOc2ccccc21,amide
103520,Add a halo to the molecule Cc1nc2ccccc2n1CCNC(=O)c1ccc(S(=O)(=O)N(C)C(C)C)cc1.,Cc1nc2ccccc2n1CCNC(=O)c1ccc(S(=O)(=O)N(C)C(C)C)cc1,halo
165982,Add a benzene ring to the molecule CC(C)Oc1cccnc1C(=O)NCc1cnn(Cc2ccccc2)c1.,CC(C)Oc1cccnc1C(=O)NCc1cnn(Cc2ccccc2)c1,benzene ring
202057,Add a nitro to the molecule CC(=O)c1cccc(NC(=O)c2nn(-c3ccccc3)c(C)cc2=O)c1.,CC(=O)c1cccc(NC(=O)c2nn(-c3ccccc3)c(C)cc2=O)c1,nitro
12955,Modify the molecule O=C(Nc1ccc2c(c1)OCCO2)c1cccc(C(=O)Nc2ccc3c(c2)OCCO3)n1 by adding a aldehyde.,O=C(Nc1ccc2c(c1)OCCO2)c1cccc(C(=O)Nc2ccc3c(c2)OCCO3)n1,aldehyde
16455,Add a carboxyl to the molecule Cc1cc(C)c(C(=O)NC[C@H]2CCO[C@@H]2C(C)C)c(C)c1.,Cc1cc(C)c(C(=O)NC[C@H]2CCO[C@@H]2C(C)C)c(C)c1,carboxyl
175637,Add a amide to the molecule Cc1cc(NC(=O)C2CCN(C(=O)N[C@@H](CC(C)C)C[NH+](C)C)CC2)no1.,Cc1cc(NC(=O)C2CCN(C(=O)N[C@@H](CC(C)C)C[NH+](C)C)CC2)no1,amide
189251,Add a benzene ring to the molecule C[C@H](C(=O)Oc1ccc2cc(Br)ccc2c1)S(C)(=O)=O.,C[C@H](C(=O)Oc1ccc2cc(Br)ccc2c1)S(C)(=O)=O,benzene ring
131790,Please add a hydroxyl to the molecule CCC[C@H](Cc1ccc(O)cc1)[NH2+]CC.,CCC[C@H](Cc1ccc(O)cc1)[NH2+]CC,hydroxyl
119249,Modify the molecule Clc1cccc(-c2cnc(CSc3nnc(Cc4ccccc4)o3)o2)c1 by adding a hydroxyl.,Clc1cccc(-c2cnc(CSc3nnc(Cc4ccccc4)o3)o2)c1,hydroxyl
118019,Modify the molecule Cc1nc(C[n+]2c(C)n(-c3ccccc3)c3ccccc32)cs1 by adding a nitro.,Cc1nc(C[n+]2c(C)n(-c3ccccc3)c3ccccc32)cs1,nitro
161946,Add a hydroxyl to the molecule Cc1ccccc1[C@H](C)NC(=O)N[C@@H]1CC(=O)N(C(C)(C)C)C1.,Cc1ccccc1[C@H](C)NC(=O)N[C@@H]1CC(=O)N(C(C)(C)C)C1,hydroxyl
188078,Please add a nitrile to the molecule O=C(c1ccccc1CSc1nc2ccccc2[nH]1)N1CCN(C[C@@H]2CCCO2)CC1.,O=C(c1ccccc1CSc1nc2ccccc2[nH]1)N1CCN(C[C@@H]2CCCO2)CC1,nitrile
182295,Please add a aldehyde to the molecule CCS(=O)(=O)Nc1cccc(C2=NN(C(=O)c3ccccc3)[C@H](c3ccccc3F)C2)c1.,CCS(=O)(=O)Nc1cccc(C2=NN(C(=O)c3ccccc3)[C@H](c3ccccc3F)C2)c1,aldehyde
103850,Please add a hydroxyl to the molecule Cc1ccc(F)c(NC(=O)N2CCC(c3nc(C)no3)CC2)c1.,Cc1ccc(F)c(NC(=O)N2CCC(c3nc(C)no3)CC2)c1,hydroxyl
53330,Modify the molecule CN(C)c1ccc([N+](=O)[O-])cc1C(=O)Nc1ccc(-n2nccc2C(F)(F)F)cc1 by adding a amide.,CN(C)c1ccc([N+](=O)[O-])cc1C(=O)Nc1ccc(-n2nccc2C(F)(F)F)cc1,amide
92468,Add a amide to the molecule CCOC(=O)C1(C)CC[NH+]([C@@H](C)C(=O)Nc2nc(C)c(C)s2)CC1.,CCOC(=O)C1(C)CC[NH+]([C@@H](C)C(=O)Nc2nc(C)c(C)s2)CC1,amide
15905,Please add a hydroxyl to the molecule CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1.,CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1,hydroxyl
90218,Add a amine to the molecule C[C@H](O)CNc1c(C#N)nnc2ccccc12.,C[C@H](O)CNc1c(C#N)nnc2ccccc12,amine
189373,Add a hydroxyl to the molecule Cc1cccnc1C[NH+]1CCC(C(=O)N(Cc2ccccc2)C2CC2)CC1.,Cc1cccnc1C[NH+]1CCC(C(=O)N(Cc2ccccc2)C2CC2)CC1,hydroxyl
216732,Modify the molecule Cc1ccc(NC(=O)[C@](F)(Cl)C(F)(F)F)c(C)c1 by adding a benzene ring.,Cc1ccc(NC(=O)[C@](F)(Cl)C(F)(F)F)c(C)c1,benzene ring
223023,Please add a halo to the molecule COC(=O)c1n[nH]c2ccc(NC(=O)N(C)CC3CCC3)cc12.,COC(=O)c1n[nH]c2ccc(NC(=O)N(C)CC3CCC3)cc12,halo
35312,Add a hydroxyl to the molecule Cc1ccc(-n2nc(O[C@@H](C)C(=O)Nc3cc(Cl)ccc3C)ccc2=O)cc1C.,Cc1ccc(-n2nc(O[C@@H](C)C(=O)Nc3cc(Cl)ccc3C)ccc2=O)cc1C,hydroxyl
141641,Please add a amide to the molecule O=C(N[C@H](CO)c1ccccc1F)c1cnc([C@H]2CCCO2)s1.,O=C(N[C@H](CO)c1ccccc1F)c1cnc([C@H]2CCCO2)s1,amide
167094,Add a benzene ring to the molecule C[NH+](C)[C@@H](CNC(=O)NNc1cccc(C#N)c1)c1ccccc1.,C[NH+](C)[C@@H](CNC(=O)NNc1cccc(C#N)c1)c1ccccc1,benzene ring
157715,Modify the molecule CCn1cc(CN2CC[C@@H](NS(C)(=O)=O)C2)cn1 by adding a hydroxyl.,CCn1cc(CN2CC[C@@H](NS(C)(=O)=O)C2)cn1,hydroxyl
195397,Modify the molecule CC[C@@H](CSC)N(C)C(=O)c1cccc(OC(C)C)n1 by adding a carboxyl.,CC[C@@H](CSC)N(C)C(=O)c1cccc(OC(C)C)n1,carboxyl
5502,Please add a benzene ring to the molecule C[C@@H]1CCN(C(=O)c2ccccc2[N+](=O)[O-])c2ccccc21.,C[C@@H]1CCN(C(=O)c2ccccc2[N+](=O)[O-])c2ccccc21,benzene ring
103881,Add a amide to the molecule C[C@H](CC(=O)Nc1nnn[n-]1)c1ccc(F)cc1.,C[C@H](CC(=O)Nc1nnn[n-]1)c1ccc(F)cc1,amide
235127,Add a amide to the molecule CCOc1ccc(NC(=O)CCn2ccccc2=O)cc1Cl.,CCOc1ccc(NC(=O)CCn2ccccc2=O)cc1Cl,amide
36970,Please add a carboxyl to the molecule Clc1ccc(C2=NN3[C@@H](C2)c2ccccc2O[C@H]3c2ccncc2)cc1.,Clc1ccc(C2=NN3[C@@H](C2)c2ccccc2O[C@H]3c2ccncc2)cc1,carboxyl
76943,Add a carboxyl to the molecule COc1ccc(C2=[NH+]CN(c3ccc(C)cc3)C(=S)N2)cc1.,COc1ccc(C2=[NH+]CN(c3ccc(C)cc3)C(=S)N2)cc1,carboxyl
69346,Modify the molecule CC(C)(C)c1ccc(OCC(=O)NNC(=O)Nc2ccccc2)c(Br)c1 by adding a benzene ring.,CC(C)(C)c1ccc(OCC(=O)NNC(=O)Nc2ccccc2)c(Br)c1,benzene ring
61782,Please add a halo to the molecule CONC(=O)[C@@H]1CCC(=O)N(C)[C@@H]1c1ccc(C(F)(F)F)cc1.,CONC(=O)[C@@H]1CCC(=O)N(C)[C@@H]1c1ccc(C(F)(F)F)cc1,halo
96775,Add a nitro to the molecule COc1cccc(NC2CCN(C(=O)Cc3ccccc3Cl)CC2)c1.,COc1cccc(NC2CCN(C(=O)Cc3ccccc3Cl)CC2)c1,nitro
23232,Please add a amine to the molecule CN(C)S(=O)(=O)N(C)[C@H]1CCN(c2ccccc2Cl)C1=O.,CN(C)S(=O)(=O)N(C)[C@H]1CCN(c2ccccc2Cl)C1=O,amine
196154,Please add a nitro to the molecule O=C(NNC(=O)c1ccncc1)NC1CCCCC1.,O=C(NNC(=O)c1ccncc1)NC1CCCCC1,nitro
131758,Add a thiol to the molecule C[NH+](C)[C@H]1CC[C@@H](NC(=O)C(=O)Nc2cccnc2Cl)C1.,C[NH+](C)[C@H]1CC[C@@H](NC(=O)C(=O)Nc2cccnc2Cl)C1,thiol
118373,Add a amide to the molecule CC[C@@H]1S/C(=N\N=C\c2cccc(OS(=O)(=O)c3ccc(Cl)c(Cl)c3)c2)NC1=O.,CC[C@@H]1S/C(=N\N=C\c2cccc(OS(=O)(=O)c3ccc(Cl)c(Cl)c3)c2)NC1=O,amide
108586,Add a hydroxyl to the molecule CCNC(=O)C1CCN(c2ccc([N+](=O)[O-])s2)CC1.,CCNC(=O)C1CCN(c2ccc([N+](=O)[O-])s2)CC1,hydroxyl
8003,Please add a nitro to the molecule Cc1ccc(N2CC[C@H](CO)C2)c(Cl)c1.,Cc1ccc(N2CC[C@H](CO)C2)c(Cl)c1,nitro
189238,Add a halo to the molecule CCOC(=O)c1cc(S(=O)(=O)N2CCN(c3ccc(C(C)=O)cc3)CC2)cn1C.,CCOC(=O)c1cc(S(=O)(=O)N2CCN(c3ccc(C(C)=O)cc3)CC2)cn1C,halo
98121,Add a amide to the molecule C#CCCN1CCN(C(=O)c2nn(-c3ccccc3)cc2OC)CC1.,C#CCCN1CCN(C(=O)c2nn(-c3ccccc3)cc2OC)CC1,amide
191426,Modify the molecule Cc1cccc(Cn2cccc(C(=O)N3CCOc4ccccc4C3)c2=O)c1 by adding a benzene ring.,Cc1cccc(Cn2cccc(C(=O)N3CCOc4ccccc4C3)c2=O)c1,benzene ring
141464,Modify the molecule C=CCN1C(=O)[C@@H](CC(=O)Nc2ccc(F)cc2)S/C1=N\c1ccc(F)cc1 by adding a hydroxyl.,C=CCN1C(=O)[C@@H](CC(=O)Nc2ccc(F)cc2)S/C1=N\c1ccc(F)cc1,hydroxyl
53922,Add a hydroxyl to the molecule CCOc1ccc2c(c1)sc(=S)n2CN1C[C@H](C)O[C@@H](C)C1.,CCOc1ccc2c(c1)sc(=S)n2CN1C[C@H](C)O[C@@H](C)C1,hydroxyl
152221,Modify the molecule O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1 by adding a aldehyde.,O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1,aldehyde
80630,Please add a hydroxyl to the molecule C[C@@H](NS(C)(=O)=O)C(=O)NCc1cccnc1Oc1ccccc1F.,C[C@@H](NS(C)(=O)=O)C(=O)NCc1cccnc1Oc1ccccc1F,hydroxyl
234697,Please add a nitro to the molecule CC(=O)n1cc(/C=N/NC(=O)c2ccc(Cl)cc2)c2ccccc21.,CC(=O)n1cc(/C=N/NC(=O)c2ccc(Cl)cc2)c2ccccc21,nitro
19164,Modify the molecule CNS(=O)(=O)c1cc(C(=O)NCc2ccc3c(c2)OCCO3)ccc1OC by adding a benzene ring.,CNS(=O)(=O)c1cc(C(=O)NCc2ccc3c(c2)OCCO3)ccc1OC,benzene ring
88811,Modify the molecule COc1ccc(Cl)c(NC(=O)CCc2cc(F)ccc2F)c1 by adding a carboxyl.,COc1ccc(Cl)c(NC(=O)CCc2cc(F)ccc2F)c1,carboxyl
238170,Please add a benzene ring to the molecule Cc1ccc(-c2ncco2)cc1NC(=O)c1cccc2[nH]ccc12.,Cc1ccc(-c2ncco2)cc1NC(=O)c1cccc2[nH]ccc12,benzene ring
17750,Add a hydroxyl to the molecule c1coc(C[NH2+]C2CCCC2)c1.,c1coc(C[NH2+]C2CCCC2)c1,hydroxyl
141396,Add a amine to the molecule O=C(CSc1nc2ccc([N+](=O)[O-])cc2s1)NCCc1ccc(Cl)cc1.,O=C(CSc1nc2ccc([N+](=O)[O-])cc2s1)NCCc1ccc(Cl)cc1,amine
56194,Add a hydroxyl to the molecule C=CC[NH+]1CCN(c2ccccc2NC(=O)CSc2ccccn2)CC1.,C=CC[NH+]1CCN(c2ccccc2NC(=O)CSc2ccccn2)CC1,hydroxyl
37857,Please add a hydroxyl to the molecule COc1ccc(Nc2nc3ccc(C)cc3s2)cc1OC.,COc1ccc(Nc2nc3ccc(C)cc3s2)cc1OC,hydroxyl
168051,Please add a halo to the molecule C[C@H](CCc1ccc(Br)cc1)NC(=O)[C@@H]1Cc2ccccc2S1.,C[C@H](CCc1ccc(Br)cc1)NC(=O)[C@@H]1Cc2ccccc2S1,halo
217554,Modify the molecule COc1cccc(C[C@@H](C)N[C@H]2CCOc3ccccc32)c1 by adding a benzene ring.,COc1cccc(C[C@@H](C)N[C@H]2CCOc3ccccc32)c1,benzene ring
230866,Add a benzene ring to the molecule Fc1ccccc1COc1ccc2c(c1)OCO2.,Fc1ccccc1COc1ccc2c(c1)OCO2,benzene ring
75113,Modify the molecule [NH3+]CCN1CCCN(C(=O)Nc2ccc(F)cc2)CC1 by adding a benzene ring.,[NH3+]CCN1CCCN(C(=O)Nc2ccc(F)cc2)CC1,benzene ring
211458,Please add a hydroxyl to the molecule Cc1cnc(OCc2nnc(Cc3ccccc3C)o2)c([N+](=O)[O-])c1.,Cc1cnc(OCc2nnc(Cc3ccccc3C)o2)c([N+](=O)[O-])c1,hydroxyl
74536,Add a carboxyl to the molecule O=c1[nH]c(CNc2cccc(Cl)c2)nc2scc(-c3ccccc3)c12.,O=c1[nH]c(CNc2cccc(Cl)c2)nc2scc(-c3ccccc3)c12,carboxyl
191396,Modify the molecule Cc1c(OCC#N)ccc2c1O/C(=C\c1ccncc1)C2=O by adding a halo.,Cc1c(OCC#N)ccc2c1O/C(=C\c1ccncc1)C2=O,halo
172240,Modify the molecule ClCCc1nc2cnccc2n1[C@H]1C[C@H]2CC[C@@H]1C2 by adding a hydroxyl.,ClCCc1nc2cnccc2n1[C@H]1C[C@H]2CC[C@@H]1C2,hydroxyl
44074,Modify the molecule CC(C)[C@H]([NH2+][C@H](C)[C@H](C)c1ccccc1)C(=O)N1CCCC1 by adding a hydroxyl.,CC(C)[C@H]([NH2+][C@H](C)[C@H](C)c1ccccc1)C(=O)N1CCCC1,hydroxyl
99020,Modify the molecule O=C([O-])c1ccc2c(c1)OCCOCCOCCO2 by adding a nitro.,O=C([O-])c1ccc2c(c1)OCCOCCOCCO2,nitro
191798,Please add a aldehyde to the molecule CCNC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2cccc(S(=O)(=O)NC)c2)C1.,CCNC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2cccc(S(=O)(=O)NC)c2)C1,aldehyde
66777,Add a halo to the molecule Cc1nc(N2CC[C@](O)(C(F)(F)F)C2)nc(C)c1CC(C)C.,Cc1nc(N2CC[C@](O)(C(F)(F)F)C2)nc(C)c1CC(C)C,halo
86804,Please add a amide to the molecule CCC[NH+](C)C[C@H]1CCN(c2ccc(C(C)=O)cc2[N+](=O)[O-])C1.,CCC[NH+](C)C[C@H]1CCN(c2ccc(C(C)=O)cc2[N+](=O)[O-])C1,amide
87674,Add a amide to the molecule Cc1nn(Cc2ccc(Cl)cc2Cl)c(C)c1NC(=O)c1c(C(=O)[O-])cnn1C.,Cc1nn(Cc2ccc(Cl)cc2Cl)c(C)c1NC(=O)c1c(C(=O)[O-])cnn1C,amide
112223,Please add a benzene ring to the molecule Cc1ccc(CC(=O)N2CCN(Cc3ccc(C(N)=O)cc3)CC2)cn1.,Cc1ccc(CC(=O)N2CCN(Cc3ccc(C(N)=O)cc3)CC2)cn1,benzene ring
25480,Modify the molecule O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C\c1ccco1 by adding a halo.,O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C\c1ccco1,halo
73400,Add a hydroxyl to the molecule COc1cccc(CNS(=O)(=O)c2cc(-c3nc(-c4ccccc4)no3)sc2C)c1.,COc1cccc(CNS(=O)(=O)c2cc(-c3nc(-c4ccccc4)no3)sc2C)c1,hydroxyl
106693,Please add a benzene ring to the molecule Cc1cc(CCCC(=O)Nc2ccc(-c3ncon3)cc2)c(C)s1.,Cc1cc(CCCC(=O)Nc2ccc(-c3ncon3)cc2)c(C)s1,benzene ring
133467,Modify the molecule CC(=O)N1N=C(c2ccc([N+](=O)[O-])s2)O[C@H]1c1cccc(NC(=O)c2ccc(Cl)cc2)c1 by adding a benzene ring.,CC(=O)N1N=C(c2ccc([N+](=O)[O-])s2)O[C@H]1c1cccc(NC(=O)c2ccc(Cl)cc2)c1,benzene ring
101055,Add a benzene ring to the molecule CC(C)[C@@H](N[C@H](C)c1cc2ccccc2o1)c1nc(-c2nc[nH]n2)no1.,CC(C)[C@@H](N[C@H](C)c1cc2ccccc2o1)c1nc(-c2nc[nH]n2)no1,benzene ring
59465,Please add a amide to the molecule Cc1noc2ncc(C(=O)N3CCOC[C@H]3C3CC3)cc12.,Cc1noc2ncc(C(=O)N3CCOC[C@H]3C3CC3)cc12,amide
51486,Please add a benzene ring to the molecule CC[C@@H](C(=O)NCc1cc(C)c(F)c(C)c1)C(N)=S.,CC[C@@H](C(=O)NCc1cc(C)c(F)c(C)c1)C(N)=S,benzene ring
130838,Modify the molecule CC[C@@H](C)NC(=O)c1ccccc1NC(=O)c1cccc(C(=O)OC)c1 by adding a carboxyl.,CC[C@@H](C)NC(=O)c1ccccc1NC(=O)c1cccc(C(=O)OC)c1,carboxyl
77336,Modify the molecule COCCN1N=C(C)Cn2c1nc1c2c(=O)n(CCOC)c(=O)n1C by adding a nitro.,COCCN1N=C(C)Cn2c1nc1c2c(=O)n(CCOC)c(=O)n1C,nitro
95763,Modify the molecule COCCc1noc(CN(C)C(=O)c2c(C)cc(C)cc2C)n1 by adding a benzene ring.,COCCc1noc(CN(C)C(=O)c2c(C)cc(C)cc2C)n1,benzene ring
142788,Add a hydroxyl to the molecule COC(=O)N1C=C[C@H]2C(C)=C[C@@H]1C(C#N)(C#N)C2(C#N)C#N.,COC(=O)N1C=C[C@H]2C(C)=C[C@@H]1C(C#N)(C#N)C2(C#N)C#N,hydroxyl
214760,Add a amine to the molecule Cc1ccc(/C=C/C(=O)Nc2cc(F)c(F)cc2F)o1.,Cc1ccc(/C=C/C(=O)Nc2cc(F)c(F)cc2F)o1,amine
122723,Modify the molecule C[C@H](NC(=O)Cn1cc(NC(=O)Cc2ccccc2F)cn1)C1CC1 by adding a benzene ring.,C[C@H](NC(=O)Cn1cc(NC(=O)Cc2ccccc2F)cn1)C1CC1,benzene ring
20028,Modify the molecule Cc1ccc(C)c2c1N[C@H](c1ccc(N(C)C)cc1)[C@@H]1CC=C[C@@H]21 by adding a aldehyde.,Cc1ccc(C)c2c1N[C@H](c1ccc(N(C)C)cc1)[C@@H]1CC=C[C@@H]21,aldehyde
162751,Add a nitro to the molecule CCOC(=O)C1CCC([NH+]2CCC(OCc3ccccc3)CC2)CC1.,CCOC(=O)C1CCC([NH+]2CCC(OCc3ccccc3)CC2)CC1,nitro
115022,Add a benzene ring to the molecule CCC[C@@H]1[C@@H](C)CCCN1C(=O)/C=C/c1ccc(C(N)=O)cc1.,CCC[C@@H]1[C@@H](C)CCCN1C(=O)/C=C/c1ccc(C(N)=O)cc1,benzene ring
64220,Please add a halo to the molecule COc1ccccc1[N-]S(=O)(=O)c1ccc2oc(S[C@H](C)C(=O)N3CCNC3=O)nc2c1.,COc1ccccc1[N-]S(=O)(=O)c1ccc2oc(S[C@H](C)C(=O)N3CCNC3=O)nc2c1,halo
192897,Modify the molecule CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1 by adding a aldehyde.,CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1,aldehyde
1071,Please add a carboxyl to the molecule CC1(C)Cc2occc2[C@@H]([NH2+]Cc2ccc(COC3CCOCC3)cc2)C1.,CC1(C)Cc2occc2[C@@H]([NH2+]Cc2ccc(COC3CCOCC3)cc2)C1,carboxyl
140860,Add a benzene ring to the molecule COC(=O)c1ccc(-c2ccco2)n1CC(=O)N1CCN(c2cccc[nH+]2)CC1.,COC(=O)c1ccc(-c2ccco2)n1CC(=O)N1CCN(c2cccc[nH+]2)CC1,benzene ring
22774,Add a amide to the molecule COc1ccc(-n2nc(C)c3c2N=C(O)C[C@@H]3c2ccc(OCc3ccccc3F)c(OC)c2)cc1.,COc1ccc(-n2nc(C)c3c2N=C(O)C[C@@H]3c2ccc(OCc3ccccc3F)c(OC)c2)cc1,amide
179235,Please add a amine to the molecule CCc1ccccc1N1C[C@H](C(=O)N2CCOC[C@H]2C#N)CC1=O.,CCc1ccccc1N1C[C@H](C(=O)N2CCOC[C@H]2C#N)CC1=O,amine
230609,Please add a halo to the molecule COC[C@@H](C)N(C)C(=O)N1CCC(CC(=O)[O-])CC1.,COC[C@@H](C)N(C)C(=O)N1CCC(CC(=O)[O-])CC1,halo
129218,Modify the molecule CCCC[C@@H](Cc1nc(-c2ccccc2)cs1)[NH2+]C by adding a amide.,CCCC[C@@H](Cc1nc(-c2ccccc2)cs1)[NH2+]C,amide
82729,Modify the molecule CN(C)S(=O)(=O)c1ccc2c(c1)c(C(N)=O)cn2C by adding a hydroxyl.,CN(C)S(=O)(=O)c1ccc2c(c1)c(C(N)=O)cn2C,hydroxyl
120686,Modify the molecule CCC[C@@H](N[C@H]1CCCN(c2ccn(C)n2)C1=O)c1ccccc1 by adding a amide.,CCC[C@@H](N[C@H]1CCCN(c2ccn(C)n2)C1=O)c1ccccc1,amide
104359,Please add a benzene ring to the molecule CCc1nn(-c2ccc(Cl)nn2)c(CC)c1CC(=O)[O-].,CCc1nn(-c2ccc(Cl)nn2)c(CC)c1CC(=O)[O-],benzene ring
222848,Please add a amine to the molecule Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12.,Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12,amine
153916,Add a benzene ring to the molecule C[C@@]1(C2CC2)CN(CC2CC2)c2ccccc2C[NH2+]1.,C[C@@]1(C2CC2)CN(CC2CC2)c2ccccc2C[NH2+]1,benzene ring
135536,Add a hydroxyl to the molecule Cc1ccc([C@@H](C)[NH2+]Cc2ccco2)cc1.,Cc1ccc([C@@H](C)[NH2+]Cc2ccco2)cc1,hydroxyl
238122,Modify the molecule CC(=O)NCC[NH2+]C[C@@H]1Cc2ccccc2S1 by adding a amine.,CC(=O)NCC[NH2+]C[C@@H]1Cc2ccccc2S1,amine
132916,Add a carboxyl to the molecule C[C@H](NC(=O)CSc1nc2ccccc2c(=O)n1C[C@H]1CCCO1)c1ccc(F)cc1.,C[C@H](NC(=O)CSc1nc2ccccc2c(=O)n1C[C@H]1CCCO1)c1ccc(F)cc1,carboxyl
171969,Please add a amine to the molecule CCOC(=O)[C@@H]1CCCN(C(=O)C[NH+](C)Cc2cccc(F)c2Cl)C1.,CCOC(=O)[C@@H]1CCCN(C(=O)C[NH+](C)Cc2cccc(F)c2Cl)C1,amine
79823,Add a aldehyde to the molecule Cc1cccc(C2=CCN(C(=O)c3cccnc3-n3cccn3)CC2)c1.,Cc1cccc(C2=CCN(C(=O)c3cccnc3-n3cccn3)CC2)c1,aldehyde
13230,Modify the molecule CC[C@H]1CN(C(=O)c2n[nH]c(C3CC3)n2)CCO1 by adding a hydroxyl.,CC[C@H]1CN(C(=O)c2n[nH]c(C3CC3)n2)CCO1,hydroxyl
98097,Add a nitrile to the molecule Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1.,Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1,nitrile
134663,Add a carboxyl to the molecule N#Cc1cccc(NC(=O)CS[C@H]2N=C3C=C(c4ccccc4)N=C3C(=O)N2Cc2ccccc2)c1.,N#Cc1cccc(NC(=O)CS[C@H]2N=C3C=C(c4ccccc4)N=C3C(=O)N2Cc2ccccc2)c1,carboxyl
89968,Please add a benzene ring to the molecule Cc1ccc(C)c(NNC(=O)C2C[C@@H](C)O[C@H](C)C2)c1.,Cc1ccc(C)c(NNC(=O)C2C[C@@H](C)O[C@H](C)C2)c1,benzene ring
139063,Add a aldehyde to the molecule C[C@H](CC(N)=O)[NH2+][C@H](CO)CC(C)(C)C.,C[C@H](CC(N)=O)[NH2+][C@H](CO)CC(C)(C)C,aldehyde
219985,Modify the molecule CCC[C@@H]([NH3+])c1noc([C@@H]2Cc3ccccc3S2)n1 by adding a nitro.,CCC[C@@H]([NH3+])c1noc([C@@H]2Cc3ccccc3S2)n1,nitro
500,Please add a hydroxyl to the molecule CC(C)OCCN1CCN(C(=O)Nc2ccccc2C(F)(F)F)CC1.,CC(C)OCCN1CCN(C(=O)Nc2ccccc2C(F)(F)F)CC1,hydroxyl
189099,Please add a amide to the molecule CCC1CCC(N(C)C(=O)c2nc(C(C)(C)C)n[nH]2)CC1.,CCC1CCC(N(C)C(=O)c2nc(C(C)(C)C)n[nH]2)CC1,amide
123214,Modify the molecule C=CC[NH+](CC(=O)[O-])Cc1nnc(-c2ccc(C)cc2)o1 by adding a amine.,C=CC[NH+](CC(=O)[O-])Cc1nnc(-c2ccc(C)cc2)o1,amine
62433,Modify the molecule O=C(COc1ccc(Cl)cc1Cl)Nc1ccccc1C(=O)N1CCCCCC1 by adding a benzene ring.,O=C(COc1ccc(Cl)cc1Cl)Nc1ccccc1C(=O)N1CCCCCC1,benzene ring
21665,Modify the molecule CCOc1cc([N+](=O)[O-])ccc1NC(=O)C[C@H]1Sc2ccccc2NC1=O by adding a amide.,CCOc1cc([N+](=O)[O-])ccc1NC(=O)C[C@H]1Sc2ccccc2NC1=O,amide
27089,Modify the molecule COc1ccc(C[NH+]2CCN(CCO)CC2)cc1 by adding a amide.,COc1ccc(C[NH+]2CCN(CCO)CC2)cc1,amide
140930,Add a nitro to the molecule CCCN(CC#N)Cc1noc(-c2ccoc2)n1.,CCCN(CC#N)Cc1noc(-c2ccoc2)n1,nitro
200443,Add a halo to the molecule COC[C@H](C)NC(=S)N1CCN(c2ncccn2)CC1.,COC[C@H](C)NC(=S)N1CCN(c2ncccn2)CC1,halo
239372,Modify the molecule COc1cc(=O)n(-c2ccccc2)nc1C(=O)N1CCC[C@@H](C)C1 by adding a hydroxyl.,COc1cc(=O)n(-c2ccccc2)nc1C(=O)N1CCC[C@@H](C)C1,hydroxyl
210560,Modify the molecule Cc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2Cl)cc1N1CCCCC1=O by adding a benzene ring.,Cc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2Cl)cc1N1CCCCC1=O,benzene ring
54194,Please add a nitro to the molecule CC[NH+]1CC[C@H](CNCc2ccc(C(=O)[O-])cn2)C1.,CC[NH+]1CC[C@H](CNCc2ccc(C(=O)[O-])cn2)C1,nitro
147872,Please add a aldehyde to the molecule O=C(NC1CCN(C(=S)NCc2ccco2)CC1)c1ccc(F)cc1.,O=C(NC1CCN(C(=S)NCc2ccco2)CC1)c1ccc(F)cc1,aldehyde
248058,Add a amide to the molecule C[C@@H]1C[C@@H]1C(=O)N1CCN(c2c(F)cc(C#N)cc2F)CC1.,C[C@@H]1C[C@@H]1C(=O)N1CCN(c2c(F)cc(C#N)cc2F)CC1,amide
64639,Add a hydroxyl to the molecule C=CCOc1ccccc1C(=O)N/N=C(/C)c1cc(O)ccc1O.,C=CCOc1ccccc1C(=O)N/N=C(/C)c1cc(O)ccc1O,hydroxyl
8862,Modify the molecule NC(=O)c1cccc(CN(Cc2ccccc2)C(=O)Nc2ccc(Cl)c(Cl)c2)c1 by adding a benzene ring.,NC(=O)c1cccc(CN(Cc2ccccc2)C(=O)Nc2ccc(Cl)c(Cl)c2)c1,benzene ring
48605,Modify the molecule Cc1nc(C)c([C@@H](C)NCC[C@H]2CSCC[NH2+]2)s1 by adding a amide.,Cc1nc(C)c([C@@H](C)NCC[C@H]2CSCC[NH2+]2)s1,amide
155800,Modify the molecule Cc1cscc1C(=O)N[C@@H](C#N)c1ccccc1 by adding a amine.,Cc1cscc1C(=O)N[C@@H](C#N)c1ccccc1,amine
199846,Please add a benzene ring to the molecule Cc1cc(NC(=O)CCCCl)n(-c2nc(C)c(C)c([O-])n2)n1.,Cc1cc(NC(=O)CCCCl)n(-c2nc(C)c(C)c([O-])n2)n1,benzene ring
101077,Please add a nitro to the molecule C[C@H]1CCCN(C(=O)COC(=O)[C@@H]2COc3ccccc3O2)C1.,C[C@H]1CCCN(C(=O)COC(=O)[C@@H]2COc3ccccc3O2)C1,nitro
105065,Please add a hydroxyl to the molecule CNC(=O)c1sc2ccccc2c1C[C@H]1CCCCN1C(=O)Cn1nc(C)ccc1=O.,CNC(=O)c1sc2ccccc2c1C[C@H]1CCCCN1C(=O)Cn1nc(C)ccc1=O,hydroxyl
97771,Add a hydroxyl to the molecule O=C(CBr)c1ccc(-c2ccc([N+](=O)[O-])cc2Cl)o1.,O=C(CBr)c1ccc(-c2ccc([N+](=O)[O-])cc2Cl)o1,hydroxyl
230568,Modify the molecule COc1ccc([C@@H]2CC(=O)N(CC(=O)Nc3cccc(C)c3C)c3ccccc3S2)cc1OC by adding a benzene ring.,COc1ccc([C@@H]2CC(=O)N(CC(=O)Nc3cccc(C)c3C)c3ccccc3S2)cc1OC,benzene ring
236402,Add a hydroxyl to the molecule Cc1ccc(NC(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)cc1S(C)(=O)=O.,Cc1ccc(NC(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)cc1S(C)(=O)=O,hydroxyl
76634,Modify the molecule COc1cc2c(cc1OC)CN(C(=O)NC[C@H](C)Cn1cccn1)CC2 by adding a carboxyl.,COc1cc2c(cc1OC)CN(C(=O)NC[C@H](C)Cn1cccn1)CC2,carboxyl
223145,Please add a benzene ring to the molecule CC(=O)N[C@@H]1CN(Cc2ccc(-n3cccn3)cc2)C[C@H]1c1ccc(C)cc1.,CC(=O)N[C@@H]1CN(Cc2ccc(-n3cccn3)cc2)C[C@H]1c1ccc(C)cc1,benzene ring
6253,Modify the molecule CC1CC[NH+](Cc2csc(CS(C)(=O)=O)n2)CC1 by adding a benzene ring.,CC1CC[NH+](Cc2csc(CS(C)(=O)=O)n2)CC1,benzene ring
228330,Modify the molecule CN(C)C(=O)c1ccccc1NC(=O)c1ccc(Cl)o1 by adding a benzene ring.,CN(C)C(=O)c1ccccc1NC(=O)c1ccc(Cl)o1,benzene ring
141738,Modify the molecule CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C by adding a amide.,CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C,amide
98774,Please add a nitro to the molecule Cc1cccc2c1=[NH+]C(=O)[C@@H](CN(C[C@@H]1CCCO1)C(=O)c1ccccc1F)C=2.,Cc1cccc2c1=[NH+]C(=O)[C@@H](CN(C[C@@H]1CCCO1)C(=O)c1ccccc1F)C=2,nitro
163343,Please add a benzene ring to the molecule Cc1cc(C)cc(C2=CCN(C(=O)c3n[nH]c4c3CCC4)CC2)c1.,Cc1cc(C)cc(C2=CCN(C(=O)c3n[nH]c4c3CCC4)CC2)c1,benzene ring
132057,Modify the molecule COc1ccc([C@H]2CCCN2C(=O)CN2C(=O)NC3(CCCCC3)C2=O)cc1OC by adding a benzene ring.,COc1ccc([C@H]2CCCN2C(=O)CN2C(=O)NC3(CCCCC3)C2=O)cc1OC,benzene ring
159309,Please add a halo to the molecule C[C@H]1CCN(C(=O)c2c(F)cccc2F)C[C@H]1O.,C[C@H]1CCN(C(=O)c2c(F)cccc2F)C[C@H]1O,halo
201157,Please add a nitro to the molecule CS(=O)(=O)N1CCC[C@@H](C[S@@](=O)c2ncccc2N)C1.,CS(=O)(=O)N1CCC[C@@H](C[S@@](=O)c2ncccc2N)C1,nitro
59207,Please add a hydroxyl to the molecule COCCN(C(=O)C[NH+]1[C@@H](C)C[C@H]2CCCC[C@@H]21)[C@@H]1CCS(=O)(=O)C1.,COCCN(C(=O)C[NH+]1[C@@H](C)C[C@H]2CCCC[C@@H]21)[C@@H]1CCS(=O)(=O)C1,hydroxyl
108319,Please add a hydroxyl to the molecule CCS(=O)(=O)c1ccc2oc([C@H]3CC[NH+](CC4CCCCC4)C3)nc2c1.,CCS(=O)(=O)c1ccc2oc([C@H]3CC[NH+](CC4CCCCC4)C3)nc2c1,hydroxyl
201860,Please add a hydroxyl to the molecule CC(=O)Nc1ccc(C[NH+]2CCC[C@@H](CNC(=O)c3cccnc3)C2)cc1.,CC(=O)Nc1ccc(C[NH+]2CCC[C@@H](CNC(=O)c3cccnc3)C2)cc1,hydroxyl
122322,Modify the molecule CC(=O)Nc1cc(NC(=O)CCC(=O)c2ccc(F)cc2F)ccc1F by adding a hydroxyl.,CC(=O)Nc1cc(NC(=O)CCC(=O)c2ccc(F)cc2F)ccc1F,hydroxyl
248033,Add a amide to the molecule NC(=O)CN1CC[NH+](Cc2nc(C3CC3)no2)CC1.,NC(=O)CN1CC[NH+](Cc2nc(C3CC3)no2)CC1,amide
117838,Add a nitrile to the molecule O[C@H](c1ccc(Cl)cc1)c1ccccc1Cl.,O[C@H](c1ccc(Cl)cc1)c1ccccc1Cl,nitrile
207813,Add a nitro to the molecule COC(=O)CCC(=O)OC[C@]1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C=C[C@@](C)(CC[C@@H]21)C3.,COC(=O)CCC(=O)OC[C@]1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C=C[C@@](C)(CC[C@@H]21)C3,nitro
84735,Please add a benzene ring to the molecule Cc1cccc2c(CC(=O)NCc3ccnc(OC(C)(C)C)c3)c[nH]c12.,Cc1cccc2c(CC(=O)NCc3ccnc(OC(C)(C)C)c3)c[nH]c12,benzene ring
248765,Please add a nitro to the molecule COCCCN1C(=O)S/C(=C\c2sccc2C)C1=O.,COCCCN1C(=O)S/C(=C\c2sccc2C)C1=O,nitro
89373,Please add a amine to the molecule CCOCCSc1ccccc1S(C)(=O)=O.,CCOCCSc1ccccc1S(C)(=O)=O,amine
90990,Add a carboxyl to the molecule CC(C)NC(=O)CSc1n[nH]c(N/N=C/c2ccc(Br)cc2)n1.,CC(C)NC(=O)CSc1n[nH]c(N/N=C/c2ccc(Br)cc2)n1,carboxyl
32084,Add a hydroxyl to the molecule COCc1cccc(NC(=O)N[C@H](C)c2ncc(C)s2)c1.,COCc1cccc(NC(=O)N[C@H](C)c2ncc(C)s2)c1,hydroxyl
160840,Add a hydroxyl to the molecule O=C(C[n+]1ccc(C(=O)NCCO)cc1)c1ccc(-c2ccccc2)cc1.,O=C(C[n+]1ccc(C(=O)NCCO)cc1)c1ccc(-c2ccccc2)cc1,hydroxyl
106939,Please add a hydroxyl to the molecule CCCOc1cc([N+](=O)[O-])c(Cl)cc1NC(C)=O.,CCCOc1cc([N+](=O)[O-])c(Cl)cc1NC(C)=O,hydroxyl
190908,Add a amine to the molecule Cc1ccc(C(C)C)c(OC[C@@H](O)C[NH+]2C(C)(C)CC(O)CC2(C)C)c1.,Cc1ccc(C(C)C)c(OC[C@@H](O)C[NH+]2C(C)(C)CC(O)CC2(C)C)c1,amine
147413,Add a benzene ring to the molecule Cc1ccc(CN(C)[C@H]2CS(=O)(=O)c3ccccc32)s1.,Cc1ccc(CN(C)[C@H]2CS(=O)(=O)c3ccccc32)s1,benzene ring
172639,Please add a hydroxyl to the molecule CC[C@H]1COCCN1C(=O)Cc1ccon1.,CC[C@H]1COCCN1C(=O)Cc1ccon1,hydroxyl
108591,Please add a hydroxyl to the molecule CC(C)(C)[C@@H](O)CCNC(=O)[C@H]1CC(=O)N(c2ccc(Cl)cc2)C1.,CC(C)(C)[C@@H](O)CCNC(=O)[C@H]1CC(=O)N(c2ccc(Cl)cc2)C1,hydroxyl
113171,Modify the molecule Cc1cccc(NC(=O)C[C@H]2SC(=O)N(Cc3ccccc3)C2=O)c1 by adding a amide.,Cc1cccc(NC(=O)C[C@H]2SC(=O)N(Cc3ccccc3)C2=O)c1,amide
90308,Add a nitro to the molecule O=C1CCC[C@H]1[C@@H]1CCC[NH+]1CC1CCC1.,O=C1CCC[C@H]1[C@@H]1CCC[NH+]1CC1CCC1,nitro
155433,Modify the molecule COc1ccc(OC)c([C@H](C)NC(=O)[C@@H]2CCCN(S(C)(=O)=O)C2)c1 by adding a halo.,COc1ccc(OC)c([C@H](C)NC(=O)[C@@H]2CCCN(S(C)(=O)=O)C2)c1,halo
236637,Please add a benzene ring to the molecule Cc1[nH]c2ccccc2c1[C@@H]1c2ccccc2C(=O)N1CCC(=O)Nc1ccc(F)cc1.,Cc1[nH]c2ccccc2c1[C@@H]1c2ccccc2C(=O)N1CCC(=O)Nc1ccc(F)cc1,benzene ring
183418,Add a amine to the molecule O=C(c1cccc(-c2ccoc2)c1)N1CCCC[C@H]1C1OCCO1.,O=C(c1cccc(-c2ccoc2)c1)N1CCCC[C@H]1C1OCCO1,amine
157875,Please add a amide to the molecule CC[C@H](C)NC(=S)NNC(=O)c1ccncc1.,CC[C@H](C)NC(=S)NNC(=O)c1ccncc1,amide
10741,Add a aldehyde to the molecule C[C@@H](Sc1ncccn1)c1c(F)cccc1F.,C[C@@H](Sc1ncccn1)c1c(F)cccc1F,aldehyde
240020,Modify the molecule CCCn1nccc1CNc1ccc(C)cc1 by adding a amine.,CCCn1nccc1CNc1ccc(C)cc1,amine
160753,Modify the molecule CCC[C@H](NC(=O)Cn1cccc1C(=O)[O-])c1cccs1 by adding a aldehyde.,CCC[C@H](NC(=O)Cn1cccc1C(=O)[O-])c1cccs1,aldehyde
64322,Add a benzene ring to the molecule CC[C@H](CNC(=O)Nc1ccc(C)c(C(N)=O)c1)[NH+]1CCc2ccccc2C1.,CC[C@H](CNC(=O)Nc1ccc(C)c(C(N)=O)c1)[NH+]1CCc2ccccc2C1,benzene ring
15238,Add a hydroxyl to the molecule Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1.,Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1,hydroxyl
29574,Modify the molecule COC(=O)c1cc(N2CCOCC2)ccc1NC(=O)c1ccc(OC)cc1 by adding a aldehyde.,COC(=O)c1cc(N2CCOCC2)ccc1NC(=O)c1ccc(OC)cc1,aldehyde
18990,Add a aldehyde to the molecule O=S(=O)(Cc1nc(-c2cccs2)no1)c1ccc2ccccc2n1.,O=S(=O)(Cc1nc(-c2cccs2)no1)c1ccc2ccccc2n1,aldehyde
131553,Add a hydroxyl to the molecule CC(=O)C[C@H]1CCCCN1S(=O)(=O)C1CCS(=O)(=O)CC1.,CC(=O)C[C@H]1CCCCN1S(=O)(=O)C1CCS(=O)(=O)CC1,hydroxyl
125251,Please add a amide to the molecule COc1ccc(S(=O)(=O)/N=C(\[O-])c2cc3c(s2)CCC3)cc1OC.,COc1ccc(S(=O)(=O)/N=C(\[O-])c2cc3c(s2)CCC3)cc1OC,amide
150652,Please add a benzene ring to the molecule CC(=O)c1ccc(NC(=O)/C=C/c2ccc(F)cc2)cc1.,CC(=O)c1ccc(NC(=O)/C=C/c2ccc(F)cc2)cc1,benzene ring
66545,Please add a aldehyde to the molecule C#CCN(C(=O)NCc1ncc(C(C)(C)C)o1)[C@H]1CCS(=O)(=O)C1.,C#CCN(C(=O)NCc1ncc(C(C)(C)C)o1)[C@H]1CCS(=O)(=O)C1,aldehyde
139392,Modify the molecule C=CCNC(=O)NC(=O)CN1C(=O)N[C@](C)(c2ccc(Cl)cc2Cl)C1=O by adding a hydroxyl.,C=CCNC(=O)NC(=O)CN1C(=O)N[C@](C)(c2ccc(Cl)cc2Cl)C1=O,hydroxyl
118264,Modify the molecule Cc1ccc(Cl)c2c1NC(=O)C2 by adding a hydroxyl.,Cc1ccc(Cl)c2c1NC(=O)C2,hydroxyl
130894,Modify the molecule Cc1ccc([C@@H](C)NC(=O)c2ccc(N3CCNC3=O)cc2)o1 by adding a carboxyl.,Cc1ccc([C@@H](C)NC(=O)c2ccc(N3CCNC3=O)cc2)o1,carboxyl
7235,Please add a hydroxyl to the molecule O=C(Nc1ccc(OC(F)(F)F)cc1)c1cc([O-])n(-c2ccccc2)c(=O)n1.,O=C(Nc1ccc(OC(F)(F)F)cc1)c1cc([O-])n(-c2ccccc2)c(=O)n1,hydroxyl
73154,Please add a benzene ring to the molecule CC[NH2+][C@H](C)c1cnc([C@H]2C[NH+]3CCN2CC3)nc1C.,CC[NH2+][C@H](C)c1cnc([C@H]2C[NH+]3CCN2CC3)nc1C,benzene ring
33627,Add a hydroxyl to the molecule CO[C@H](C)c1cccc(NC(=O)NCCC(=O)Nc2ccc(C)cc2Cl)c1.,CO[C@H](C)c1cccc(NC(=O)NCCC(=O)Nc2ccc(C)cc2Cl)c1,hydroxyl
48366,Add a hydroxyl to the molecule Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1.,Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1,hydroxyl
129297,Add a benzene ring to the molecule COc1cccc2cc(C(=O)Nc3nnc(CSc4ccccc4)o3)oc12.,COc1cccc2cc(C(=O)Nc3nnc(CSc4ccccc4)o3)oc12,benzene ring
131080,Modify the molecule CC[C@H](NC(=O)C(=O)Nc1cccc(Cl)c1Cl)c1ccncc1 by adding a amide.,CC[C@H](NC(=O)C(=O)Nc1cccc(Cl)c1Cl)c1ccncc1,amide
145818,Modify the molecule C[NH+]1CCC(C[NH+](C)Cc2ccn(Cc3ccccc3)c2)CC1 by adding a aldehyde.,C[NH+]1CCC(C[NH+](C)Cc2ccn(Cc3ccccc3)c2)CC1,aldehyde
141775,Modify the molecule C[C@H]1CN(C)c2ccccc2CN1C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1 by adding a hydroxyl.,C[C@H]1CN(C)c2ccccc2CN1C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,hydroxyl
146660,Modify the molecule C1C[C@H]([NH2+]C(C2CC2)C2CC2)CN1 by adding a hydroxyl.,C1C[C@H]([NH2+]C(C2CC2)C2CC2)CN1,hydroxyl
189054,Modify the molecule CC[NH2+]C[C@]1(c2cc(C)cc(C)c2)CCC[C@H]1C by adding a benzene ring.,CC[NH2+]C[C@]1(c2cc(C)cc(C)c2)CCC[C@H]1C,benzene ring
72104,Add a hydroxyl to the molecule Cc1cc(NC(=O)NCc2ccc(Cl)cc2)n(Cc2ccccn2)n1.,Cc1cc(NC(=O)NCc2ccc(Cl)cc2)n(Cc2ccccn2)n1,hydroxyl
127437,Please add a benzene ring to the molecule C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1.,C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1,benzene ring
210835,Add a hydroxyl to the molecule CC(C)c1ccc(C(=O)NC2=NCCS2)cc1.,CC(C)c1ccc(C(=O)NC2=NCCS2)cc1,hydroxyl
125422,Add a aldehyde to the molecule O=C(C[C@@H]1C(=O)Nc2c(-c3ccc(F)cc3)cnn21)Nc1cccc(OC(F)(F)F)c1.,O=C(C[C@@H]1C(=O)Nc2c(-c3ccc(F)cc3)cnn21)Nc1cccc(OC(F)(F)F)c1,aldehyde
55151,Modify the molecule COc1cc(NCc2c[nH]nc2C(C)(C)C)c(OC)cc1Cl by adding a benzene ring.,COc1cc(NCc2c[nH]nc2C(C)(C)C)c(OC)cc1Cl,benzene ring
42308,Please add a halo to the molecule CC(=O)N1N/C(=C2\C(=O)N(C)C(=O)N=C2[O-])C[C@@H]1c1cccc2ccccc12.,CC(=O)N1N/C(=C2\C(=O)N(C)C(=O)N=C2[O-])C[C@@H]1c1cccc2ccccc12,halo
39282,Modify the molecule C=CC[n+]1c(Nc2ccccc2OC)sc(NC(C)=O)c1-c1ccccc1 by adding a benzene ring.,C=CC[n+]1c(Nc2ccccc2OC)sc(NC(C)=O)c1-c1ccccc1,benzene ring
164594,Please add a benzene ring to the molecule C/[NH+]=C(\[S-])NCCc1c[nH]c2ccccc12.,C/[NH+]=C(\[S-])NCCc1c[nH]c2ccccc12,benzene ring
66510,Add a hydroxyl to the molecule CCN(CC)C(=S)NC(=O)c1cc(Br)ccc1OC.,CCN(CC)C(=S)NC(=O)c1cc(Br)ccc1OC,hydroxyl
204115,Modify the molecule O=C(NCCc1nc(-c2ccc(F)cc2)c[nH]1)c1nc2ccccc2c(=O)[nH]1 by adding a hydroxyl.,O=C(NCCc1nc(-c2ccc(F)cc2)c[nH]1)c1nc2ccccc2c(=O)[nH]1,hydroxyl
66340,Add a amide to the molecule C[C@H]1CC[C@@H](C)C[NH+]1Cc1csc(CS(C)(=O)=O)n1.,C[C@H]1CC[C@@H](C)C[NH+]1Cc1csc(CS(C)(=O)=O)n1,amide
221482,Please add a nitro to the molecule C[C@@H](NC(=O)Cn1cnc2ccc(F)cc2c1=O)c1ccc(F)cc1.,C[C@@H](NC(=O)Cn1cnc2ccc(F)cc2c1=O)c1ccc(F)cc1,nitro
74286,Please add a amide to the molecule COc1cc2s/c(=N\C(=O)Cc3ccccc3)n(CCSC)c2cc1OC.,COc1cc2s/c(=N\C(=O)Cc3ccccc3)n(CCSC)c2cc1OC,amide
32464,Add a thiol to the molecule Cc1ccccc1OCC(=O)NCCC(=O)[O-].,Cc1ccccc1OCC(=O)NCCC(=O)[O-],thiol
16539,Modify the molecule CC(C)(C)CN(C[C@H](O)c1ccccc1)S(=O)(=O)c1cccc2c1COC2=O by adding a amide.,CC(C)(C)CN(C[C@H](O)c1ccccc1)S(=O)(=O)c1cccc2c1COC2=O,amide
108147,Modify the molecule CCCCS(=O)(=O)N1CCC[C@@H]1C(=O)N1CCc2[nH]ncc2C1 by adding a benzene ring.,CCCCS(=O)(=O)N1CCC[C@@H]1C(=O)N1CCc2[nH]ncc2C1,benzene ring
221142,Modify the molecule Cc1cc(C)c(OCC(=O)Nc2cccc(-c3ccc(CO)o3)c2)c(Br)c1 by adding a hydroxyl.,Cc1cc(C)c(OCC(=O)Nc2cccc(-c3ccc(CO)o3)c2)c(Br)c1,hydroxyl
228528,Modify the molecule COc1ccccc1OCCC(=O)N[C@@H]1CCCC[C@@H]1C by adding a amine.,COc1ccccc1OCCC(=O)N[C@@H]1CCCC[C@@H]1C,amine
65140,Add a halo to the molecule C=CCn1c(SCc2nc3ccccc3[nH]2)nnc1-c1cccnc1.,C=CCn1c(SCc2nc3ccccc3[nH]2)nnc1-c1cccnc1,halo
217435,Please add a amine to the molecule CC(C)[C@@H]([NH2+]C[C@H]1CCC[C@H](O)C1)c1ccc2c(c1)CCO2.,CC(C)[C@@H]([NH2+]C[C@H]1CCC[C@H](O)C1)c1ccc2c(c1)CCO2,amine
103080,Add a aldehyde to the molecule COc1ccc(F)cc1NC(=O)c1cc2c([nH]c1=O)CCCC2.,COc1ccc(F)cc1NC(=O)c1cc2c([nH]c1=O)CCCC2,aldehyde
184443,Please add a thiol to the molecule CC(C)(C)C[C@H](CO)NC(=O)c1cncc(F)c1.,CC(C)(C)C[C@H](CO)NC(=O)c1cncc(F)c1,thiol
87498,Please add a nitro to the molecule Cn1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)n1.,Cn1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)n1,nitro
161966,Add a hydroxyl to the molecule C[C@@H](SCc1cc(-c2ccc(Cl)cc2)no1)C(=O)NC(C)(C)C.,C[C@@H](SCc1cc(-c2ccc(Cl)cc2)no1)C(=O)NC(C)(C)C,hydroxyl
108388,Please add a benzene ring to the molecule CC1(C)C(C(=O)NCC2(S(C)(=O)=O)CCOCC2)C1(C)C.,CC1(C)C(C(=O)NCC2(S(C)(=O)=O)CCOCC2)C1(C)C,benzene ring
27840,Add a aldehyde to the molecule C[NH+](C)[C@H](CNC(=O)[C@@H]1Cc2ccccc2O1)c1ccc(F)cc1.,C[NH+](C)[C@H](CNC(=O)[C@@H]1Cc2ccccc2O1)c1ccc(F)cc1,aldehyde
65469,Add a amine to the molecule CCC[NH+]1CCCN(C(=O)NCCc2ccc(O)cc2)CC1.,CCC[NH+]1CCCN(C(=O)NCCc2ccc(O)cc2)CC1,amine
55296,Modify the molecule C[C@@H]1CCC[C@@H]1[NH2+]C[C@@H](c1cccc(F)c1)N(C)C by adding a amine.,C[C@@H]1CCC[C@@H]1[NH2+]C[C@@H](c1cccc(F)c1)N(C)C,amine
31970,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)Oc2cc(F)ccc2[N+](=O)[O-])cc1 by adding a amine.,Cc1ccc(O[C@@H](C)C(=O)Oc2cc(F)ccc2[N+](=O)[O-])cc1,amine
128540,Modify the molecule Cc1cc2c(c(=O)[nH]1)C(=O)O/C2=C\c1ccc(I)o1 by adding a nitro.,Cc1cc2c(c(=O)[nH]1)C(=O)O/C2=C\c1ccc(I)o1,nitro
60865,Add a amine to the molecule CCCn1cncc1[C@@H](O)[C@@]1(C#N)CCc2ccccc21.,CCCn1cncc1[C@@H](O)[C@@]1(C#N)CCc2ccccc21,amine
23150,Modify the molecule CCC(=O)N1CCC(N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1 by adding a hydroxyl.,CCC(=O)N1CCC(N[C@@H](c2ccc(F)cc2)C(F)(F)F)CC1,hydroxyl
69481,Add a aldehyde to the molecule C=C(C)C(=O)Nc1cc(Cl)c(C)c(Cl)c1O.,C=C(C)C(=O)Nc1cc(Cl)c(C)c(Cl)c1O,aldehyde
99008,Please add a benzene ring to the molecule Cc1cc(C)cc(OCCCN2C(=O)N[C@@]3(CCOc4ccccc43)C2=O)c1.,Cc1cc(C)cc(OCCCN2C(=O)N[C@@]3(CCOc4ccccc43)C2=O)c1,benzene ring
135744,Please add a carboxyl to the molecule C[C@H](O)CCC(=O)N1CCC(NC(=O)C2CC2)CC1.,C[C@H](O)CCC(=O)N1CCC(NC(=O)C2CC2)CC1,carboxyl
209132,Add a hydroxyl to the molecule Cc1nc(CN(CCO)Cc2cc(Br)ccc2F)cs1.,Cc1nc(CN(CCO)Cc2cc(Br)ccc2F)cs1,hydroxyl
94808,Add a benzene ring to the molecule C[NH+](Cc1ccc(/C(N)=N/O)cc1F)[C@@H]1CCSC1.,C[NH+](Cc1ccc(/C(N)=N/O)cc1F)[C@@H]1CCSC1,benzene ring
242162,Modify the molecule CC(C)[C@H](NC(=O)N1CCOC[C@H]1C1CC1)c1ccc(F)cc1F by adding a nitro.,CC(C)[C@H](NC(=O)N1CCOC[C@H]1C1CC1)c1ccc(F)cc1F,nitro
59752,Modify the molecule O=C(Nc1cccnc1)C(=O)N1CCN(Cc2cccs2)CC1 by adding a hydroxyl.,O=C(Nc1cccnc1)C(=O)N1CCN(Cc2cccs2)CC1,hydroxyl
115341,Modify the molecule Cc1ccc2c(c1)N(C)C(=O)c1cc(NC(=O)CC(C)(C)C)ccc1O2 by adding a amide.,Cc1ccc2c(c1)N(C)C(=O)c1cc(NC(=O)CC(C)(C)C)ccc1O2,amide
92052,Add a amine to the molecule Cn1c(CNc2c3c(nc4nncn24)CCC3)nc2ccccc21.,Cn1c(CNc2c3c(nc4nncn24)CCC3)nc2ccccc21,amine
150837,Modify the molecule CN(C(=O)C[C@@H](O)c1cccc(F)c1)[C@@H](CCO)c1ccccc1 by adding a carboxyl.,CN(C(=O)C[C@@H](O)c1cccc(F)c1)[C@@H](CCO)c1ccccc1,carboxyl
238476,Add a carboxyl to the molecule C[C@@H](C(=O)N1CCC[C@H](C(N)=O)C1)N1CCN(c2ncccc2F)CC1.,C[C@@H](C(=O)N1CCC[C@H](C(N)=O)C1)N1CCN(c2ncccc2F)CC1,carboxyl
105282,Please add a amine to the molecule O=C(C[NH+]1CCC(O)CC1)Nc1ccc(N2CCOCC2)cc1.,O=C(C[NH+]1CCC(O)CC1)Nc1ccc(N2CCOCC2)cc1,amine
233060,Modify the molecule CC[C@H](C)N1C[C@@](C)(C2CC2)[NH2+]CC12CCCCC2 by adding a benzene ring.,CC[C@H](C)N1C[C@@](C)(C2CC2)[NH2+]CC12CCCCC2,benzene ring
146900,Add a carboxyl to the molecule CN(Cc1ccc(Cl)c(Cl)c1)C(=O)C[NH3+].,CN(Cc1ccc(Cl)c(Cl)c1)C(=O)C[NH3+],carboxyl
5042,Add a halo to the molecule CC(C)[C@@H](NC(=O)NNc1ccc(C(C)(C)C)nn1)c1ccccn1.,CC(C)[C@@H](NC(=O)NNc1ccc(C(C)(C)C)nn1)c1ccccn1,halo
39739,Modify the molecule Cc1cc(S(=O)(=O)N(C)C)cc(NC(=O)CCc2ccco2)c1C by adding a nitro.,Cc1cc(S(=O)(=O)N(C)C)cc(NC(=O)CCc2ccco2)c1C,nitro
155413,Modify the molecule CN(Cc1ccncc1)C(=O)[C@@H]1CCCC[NH+]1Cc1ccccc1 by adding a benzene ring.,CN(Cc1ccncc1)C(=O)[C@@H]1CCCC[NH+]1Cc1ccccc1,benzene ring
25484,Modify the molecule Cc1ccc(C(C)C)c(O[C@H](C)C(=O)N2CCOC[C@H]2C(N)=O)c1 by adding a benzene ring.,Cc1ccc(C(C)C)c(O[C@H](C)C(=O)N2CCOC[C@H]2C(N)=O)c1,benzene ring
17286,Please add a benzene ring to the molecule CCC[NH2+]C[C@@H](C(C)C)N1C[C@@H]2CCCC[NH+]2C[C@@H]1C.,CCC[NH2+]C[C@@H](C(C)C)N1C[C@@H]2CCCC[NH+]2C[C@@H]1C,benzene ring
172560,Modify the molecule O=C(CSc1nc(-c2ccco2)n[nH]1)N[C@@H]1SC2=C(CCCC2)[C@H]1C(=O)Nc1ccccc1 by adding a hydroxyl.,O=C(CSc1nc(-c2ccco2)n[nH]1)N[C@@H]1SC2=C(CCCC2)[C@H]1C(=O)Nc1ccccc1,hydroxyl
150721,Modify the molecule Cc1cc(C)nc(N/C(=N/C(=O)NC23CC4CC(CC(C4)C2)C3)N2CCC[C@@H](C)C2)n1 by adding a amide.,Cc1cc(C)nc(N/C(=N/C(=O)NC23CC4CC(CC(C4)C2)C3)N2CCC[C@@H](C)C2)n1,amide
199169,Please add a benzene ring to the molecule O=C(NCCC(F)(F)F)N1CCOc2ccccc2C1.,O=C(NCCC(F)(F)F)N1CCOc2ccccc2C1,benzene ring
116602,Please add a amide to the molecule C[C@@H]([NH2+][C@H](C)c1ccc(F)cn1)c1ccc2c(c1)OCO2.,C[C@@H]([NH2+][C@H](C)c1ccc(F)cn1)c1ccc2c(c1)OCO2,amide
118791,Add a benzene ring to the molecule CCCN(CCCl)c1ncnc2c1CCCC2.,CCCN(CCCl)c1ncnc2c1CCCC2,benzene ring
183353,Please add a amide to the molecule CCOC[C@H]1CCCN(C(=O)N[C@H]2C[C@H](C)N(c3ccccc3)C2)C1.,CCOC[C@H]1CCCN(C(=O)N[C@H]2C[C@H](C)N(c3ccccc3)C2)C1,amide
58126,Please add a benzene ring to the molecule CC(=O)Nc1cccc(NC(=O)[C@H](C)c2ccc3ccccc3c2)c1.,CC(=O)Nc1cccc(NC(=O)[C@H](C)c2ccc3ccccc3c2)c1,benzene ring
239724,Modify the molecule CSc1cccc(NC(=O)Cn2cc(-c3nc(-c4cccc(C)c4)no3)ccc2=O)c1 by adding a halo.,CSc1cccc(NC(=O)Cn2cc(-c3nc(-c4cccc(C)c4)no3)ccc2=O)c1,halo
87085,Please add a hydroxyl to the molecule CCOc1ccc(O)c(C[NH+](CCO)[C@H]2CCc3ccccc32)c1.,CCOc1ccc(O)c(C[NH+](CCO)[C@H]2CCc3ccccc32)c1,hydroxyl
29108,Add a hydroxyl to the molecule C[C@@H]([NH2+]C1C(C)(C)C1(C)C)c1ccc(S(C)(=O)=O)cc1.,C[C@@H]([NH2+]C1C(C)(C)C1(C)C)c1ccc(S(C)(=O)=O)cc1,hydroxyl
74368,Please add a benzene ring to the molecule C[C@H]1C[C@@H]1CNC(=O)CCn1nc([O-])c2ccccc2c1=O.,C[C@H]1C[C@@H]1CNC(=O)CCn1nc([O-])c2ccccc2c1=O,benzene ring
100556,Please add a hydroxyl to the molecule COC(=O)C1=C(C)N=C(C(=O)N2CCC[C@H](C(=O)NCc3ccc(Cl)cc3)C2)[C@H]1C.,COC(=O)C1=C(C)N=C(C(=O)N2CCC[C@H](C(=O)NCc3ccc(Cl)cc3)C2)[C@H]1C,hydroxyl
157558,Modify the molecule CCc1ccc(C(=O)N(C)CCc2cccc3ccccc23)o1 by adding a benzene ring.,CCc1ccc(C(=O)N(C)CCc2cccc3ccccc23)o1,benzene ring
225311,Please add a hydroxyl to the molecule CCn1cc(C(=O)O[C@H](C)c2ccccn2)c(C(C)C)n1.,CCn1cc(C(=O)O[C@H](C)c2ccccn2)c(C(C)C)n1,hydroxyl
43570,Modify the molecule C[NH+](C)CCn1ccc(NC(=O)c2cc(NC(=O)C(C)(C)C)ccc2F)n1 by adding a benzene ring.,C[NH+](C)CCn1ccc(NC(=O)c2cc(NC(=O)C(C)(C)C)ccc2F)n1,benzene ring
220447,Please add a aldehyde to the molecule CC[NH+](Cc1ccc(OC)c(O)c1)Cc1ccccn1.,CC[NH+](Cc1ccc(OC)c(O)c1)Cc1ccccn1,aldehyde
184788,Please add a hydroxyl to the molecule O=C(Nc1nc2c(s1)C(=O)CCC2)c1ccc(Cl)cc1F.,O=C(Nc1nc2c(s1)C(=O)CCC2)c1ccc(Cl)cc1F,hydroxyl
99049,Please add a benzene ring to the molecule C[C@H](OC[C@@H](O)CN1CCn2c(nn(C)c2=O)C1)c1ccc(Cl)cc1.,C[C@H](OC[C@@H](O)CN1CCn2c(nn(C)c2=O)C1)c1ccc(Cl)cc1,benzene ring
156079,Add a hydroxyl to the molecule C[C@@H](C[NH2+][C@H](C)c1ccc2[nH]c(=O)[nH]c2c1)Oc1ccccc1F.,C[C@@H](C[NH2+][C@H](C)c1ccc2[nH]c(=O)[nH]c2c1)Oc1ccccc1F,hydroxyl
76319,Please add a amide to the molecule CC(C)CN(C(=O)NCC1CCC1)C1CC1.,CC(C)CN(C(=O)NCC1CCC1)C1CC1,amide
145982,Modify the molecule CC(=O)N[C@@H](CC(=O)NCc1ccco1)c1ccc(Cl)cc1 by adding a amide.,CC(=O)N[C@@H](CC(=O)NCc1ccco1)c1ccc(Cl)cc1,amide
22585,Add a carboxyl to the molecule N#C/C(=C\c1ccc(N2CCOCC2)cc1)[C@@H]1[NH+]=c2cc(Br)cnc2=[NH+]1.,N#C/C(=C\c1ccc(N2CCOCC2)cc1)[C@@H]1[NH+]=c2cc(Br)cnc2=[NH+]1,carboxyl
72115,Modify the molecule CCC(=O)c1cc2c(cc1NC(C)=O)OCCO2 by adding a amide.,CCC(=O)c1cc2c(cc1NC(C)=O)OCCO2,amide
225037,Please add a hydroxyl to the molecule COc1cncc(-c2ccnc(Cl)n2)c1.,COc1cncc(-c2ccnc(Cl)n2)c1,hydroxyl
117062,Modify the molecule CC[C@@H](NC(=O)c1ccn(-c2cccc(Cl)c2)n1)c1c(C)nn(C)c1C by adding a thiol.,CC[C@@H](NC(=O)c1ccn(-c2cccc(Cl)c2)n1)c1c(C)nn(C)c1C,thiol
222928,Modify the molecule C(=C/c1ccccc1)\C[NH2+]Cc1ccon1 by adding a benzene ring.,C(=C/c1ccccc1)\C[NH2+]Cc1ccon1,benzene ring
59200,Please add a amide to the molecule COCCCNc1ccc(N)c(OC(C)(C)C)n1.,COCCCNc1ccc(N)c(OC(C)(C)C)n1,amide
94099,Add a carboxyl to the molecule O=C(NC[C@@H](CCO)c1ccccc1)C1=NO[C@@H](c2ccccc2)C1.,O=C(NC[C@@H](CCO)c1ccccc1)C1=NO[C@@H](c2ccccc2)C1,carboxyl
215767,Modify the molecule CCc1nn(C)cc1C(=O)NC1CC[NH+](CC(N)=O)CC1 by adding a nitro.,CCc1nn(C)cc1C(=O)NC1CC[NH+](CC(N)=O)CC1,nitro
111746,Please add a aldehyde to the molecule COc1cccc(C[NH+](C)[C@@H](C)C(=O)Nc2ccc(Cl)cc2Cl)c1.,COc1cccc(C[NH+](C)[C@@H](C)C(=O)Nc2ccc(Cl)cc2Cl)c1,aldehyde
67635,Modify the molecule Fc1ccccc1COCC1(CS)CCOCC1 by adding a amide.,Fc1ccccc1COCC1(CS)CCOCC1,amide
76444,Modify the molecule O=C(N[C@@H]1CCOC2(CCCC2)C1)N[C@@H]1CCCC[C@@H]1OC1CCCC1 by adding a amide.,O=C(N[C@@H]1CCOC2(CCCC2)C1)N[C@@H]1CCCC[C@@H]1OC1CCCC1,amide
153276,Add a hydroxyl to the molecule CC(C)Cn1cc(NC(=O)c2ccccc2-c2nc(C(C)(C)C)no2)cn1.,CC(C)Cn1cc(NC(=O)c2ccccc2-c2nc(C(C)(C)C)no2)cn1,hydroxyl
71107,Modify the molecule C[NH2+][C@@]1(C(=O)OC)CCC[C@H](Sc2ccc(F)cc2)C1 by adding a amine.,C[NH2+][C@@]1(C(=O)OC)CCC[C@H](Sc2ccc(F)cc2)C1,amine
111280,Please add a amide to the molecule CSc1cccc(NC(=O)C[NH2+]C2(c3nccs3)CCCC2)c1.,CSc1cccc(NC(=O)C[NH2+]C2(c3nccs3)CCCC2)c1,amide
194814,Please add a hydroxyl to the molecule CCn1c(=O)c(C(=O)Nc2ccc(C)cc2Cl)nc2ccccc21.,CCn1c(=O)c(C(=O)Nc2ccc(C)cc2Cl)nc2ccccc21,hydroxyl
114047,Add a halo to the molecule CC[NH+]1CCN([C@@H]2CC[NH+](Cc3ccccc3N3C[C@H](C)O[C@H](C)C3)C2)CC1.,CC[NH+]1CCN([C@@H]2CC[NH+](Cc3ccccc3N3C[C@H](C)O[C@H](C)C3)C2)CC1,halo
110720,Modify the molecule O=C(OCc1nnsc1Cl)[C@@H]1COc2ccc(Cl)cc2C1 by adding a hydroxyl.,O=C(OCc1nnsc1Cl)[C@@H]1COc2ccc(Cl)cc2C1,hydroxyl
18641,Please add a halo to the molecule CC1(C)CC(=O)C2=C(C1)Nc1ccc3ncccc3c1[C@H]2c1ccccc1[N+](=O)[O-].,CC1(C)CC(=O)C2=C(C1)Nc1ccc3ncccc3c1[C@H]2c1ccccc1[N+](=O)[O-],halo
35622,Please add a amide to the molecule Cc1cc(C)n2nc(C(=O)OCC(=O)Nc3cccc(Cl)c3Cl)nc2n1.,Cc1cc(C)n2nc(C(=O)OCC(=O)Nc3cccc(Cl)c3Cl)nc2n1,amide
104652,Please add a hydroxyl to the molecule O=C(N[C@@H]1CC(=O)N(Cc2ccc(F)cc2)C1)c1ccc[nH]1.,O=C(N[C@@H]1CC(=O)N(Cc2ccc(F)cc2)C1)c1ccc[nH]1,hydroxyl
50580,Please add a hydroxyl to the molecule COc1cccc(C/C([O-])=N/S(=O)(=O)Cc2ccccc2)c1.,COc1cccc(C/C([O-])=N/S(=O)(=O)Cc2ccccc2)c1,hydroxyl
51341,Add a hydroxyl to the molecule CCc1ccc(C[NH+](C)Cn2nc(-c3cccc([N+](=O)[O-])c3)ccc2=O)cc1.,CCc1ccc(C[NH+](C)Cn2nc(-c3cccc([N+](=O)[O-])c3)ccc2=O)cc1,hydroxyl
95003,Add a carboxyl to the molecule COc1ccc([C@H](NC(=O)Nc2cccc(F)c2C)C2CCOCC2)cc1.,COc1ccc([C@H](NC(=O)Nc2cccc(F)c2C)C2CCOCC2)cc1,carboxyl
45199,Add a halo to the molecule Cc1cc(C(=O)N2CCc3c([nH]c4ccccc34)[C@@H]2c2cccc(C(F)(F)F)c2)n(C)n1.,Cc1cc(C(=O)N2CCc3c([nH]c4ccccc34)[C@@H]2c2cccc(C(F)(F)F)c2)n(C)n1,halo
27507,Please add a amide to the molecule C=CCNC(=O)CN1CCN(c2nc(C)nc3sc4c(c23)CCCC4)CC1.,C=CCNC(=O)CN1CCN(c2nc(C)nc3sc4c(c23)CCCC4)CC1,amide
53064,Modify the molecule Cc1cccc(/C=N/c2ccccc2)c1 by adding a halo.,Cc1cccc(/C=N/c2ccccc2)c1,halo
249241,Add a thiol to the molecule CC[C@H](NC(=O)[C@H]1CN(C)CCO1)c1ccc(Br)cc1.,CC[C@H](NC(=O)[C@H]1CN(C)CCO1)c1ccc(Br)cc1,thiol
30980,Modify the molecule COc1ccccc1[C@H](NC(=O)N[C@@H](C)Cn1cc[nH+]c1)c1nccn1C by adding a benzene ring.,COc1ccccc1[C@H](NC(=O)N[C@@H](C)Cn1cc[nH+]c1)c1nccn1C,benzene ring
249299,Please add a benzene ring to the molecule COc1ccc([C@H]([NH2+]C[C@@H]2CCS(=O)(=O)C2)C(C)C)cc1.,COc1ccc([C@H]([NH2+]C[C@@H]2CCS(=O)(=O)C2)C(C)C)cc1,benzene ring
105681,Modify the molecule CC(C)O[S@@](=O)c1cccc2ccccc12 by adding a aldehyde.,CC(C)O[S@@](=O)c1cccc2ccccc12,aldehyde
178732,Please add a hydroxyl to the molecule O=c1[nH]c2ccc(S(=O)(=O)N3CCN(c4nccs4)CC3)cc2[nH]c1=O.,O=c1[nH]c2ccc(S(=O)(=O)N3CCN(c4nccs4)CC3)cc2[nH]c1=O,hydroxyl
146061,Add a hydroxyl to the molecule C[C@H](CC1CCOCC1)[NH2+]C[C@H](O)C1CCOCC1.,C[C@H](CC1CCOCC1)[NH2+]C[C@H](O)C1CCOCC1,hydroxyl
222572,Please add a benzene ring to the molecule O=C(CSCC(F)(F)F)N[C@@H]1CCN(CC(F)(F)F)C1=O.,O=C(CSCC(F)(F)F)N[C@@H]1CCN(CC(F)(F)F)C1=O,benzene ring
146268,Add a benzene ring to the molecule O=C(NCCN1CCN(c2ccccc2)CC1)c1ccc2c(c1)OCCCO2.,O=C(NCCN1CCN(c2ccccc2)CC1)c1ccc2c(c1)OCCCO2,benzene ring
171413,Modify the molecule O=C1/C(=C/c2ccc[nH]2)c2ccccc2N1c1ccccc1 by adding a amide.,O=C1/C(=C/c2ccc[nH]2)c2ccccc2N1c1ccccc1,amide
228567,Add a hydroxyl to the molecule CCc1ccc(/C=N/OCC(=O)N(C)c2ccccc2)cc1.,CCc1ccc(/C=N/OCC(=O)N(C)c2ccccc2)cc1,hydroxyl
98303,Please add a hydroxyl to the molecule N#Cc1cc2c(nc1NC(=O)c1cncc(-c3ccccc3)c1)CCC2.,N#Cc1cc2c(nc1NC(=O)c1cncc(-c3ccccc3)c1)CCC2,hydroxyl
130581,Please add a hydroxyl to the molecule O=[N+]([O-])c1c(Br)cccc1N1CCN(Cc2ccccc2)CC1.,O=[N+]([O-])c1c(Br)cccc1N1CCN(Cc2ccccc2)CC1,hydroxyl
105924,Add a hydroxyl to the molecule CC(C)(C)OC(=O)N1C[C@@H](Oc2cccnc2)C[C@H]1C(=O)[O-].,CC(C)(C)OC(=O)N1C[C@@H](Oc2cccnc2)C[C@H]1C(=O)[O-],hydroxyl
65604,Modify the molecule CC(C)(C)OC(=O)N[C@H]1CC[C@H]([NH2+]C(CO)CO)C1 by adding a halo.,CC(C)(C)OC(=O)N[C@H]1CC[C@H]([NH2+]C(CO)CO)C1,halo
66229,Modify the molecule CC[NH2+][C@H](c1cncc(Br)c1)c1cccc(C)c1C by adding a amide.,CC[NH2+][C@H](c1cncc(Br)c1)c1cccc(C)c1C,amide
164650,Please add a aldehyde to the molecule CC/[NH+]=C(/NC[C@@H](C)CN1CCOCC1)N1CCCC1.,CC/[NH+]=C(/NC[C@@H](C)CN1CCOCC1)N1CCCC1,aldehyde
101973,Add a benzene ring to the molecule Nc1nnc(SCC(=O)NCCc2cc(N3CCCC3)ncn2)s1.,Nc1nnc(SCC(=O)NCCc2cc(N3CCCC3)ncn2)s1,benzene ring
14415,Modify the molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCCCC3)ccc2o1)N1CCC[C@@H]2CCCC[C@@H]21 by adding a hydroxyl.,O=C(CSc1nc2cc(S(=O)(=O)N3CCCCC3)ccc2o1)N1CCC[C@@H]2CCCC[C@@H]21,hydroxyl
22999,Modify the molecule Cc1cc(/C=N/NC(=O)[C@@H]2COc3ccccc3O2)c(C)n1-c1cccc(Br)c1 by adding a benzene ring.,Cc1cc(/C=N/NC(=O)[C@@H]2COc3ccccc3O2)c(C)n1-c1cccc(Br)c1,benzene ring
232763,Please add a nitro to the molecule Cc1cc(-c2cc3nc(C)c(C)c(NCCN4CCCC4=O)n3n2)no1.,Cc1cc(-c2cc3nc(C)c(C)c(NCCN4CCCC4=O)n3n2)no1,nitro
123615,Add a nitro to the molecule CS[C@@H]1CCC[C@@H]1N(C)C(=O)CCc1cccc([N+](=O)[O-])c1.,CS[C@@H]1CCC[C@@H]1N(C)C(=O)CCc1cccc([N+](=O)[O-])c1,nitro
199522,Modify the molecule COc1ccc(Nc2nn(-c3ccccc3)c3c2C(=O)C[C@@H](c2ccco2)C3)cc1 by adding a benzene ring.,COc1ccc(Nc2nn(-c3ccccc3)c3c2C(=O)C[C@@H](c2ccco2)C3)cc1,benzene ring
48455,Add a benzene ring to the molecule CCc1ccc(C(=O)NNC(=O)c2ccc(C(=O)N(C)C)cc2)cc1.,CCc1ccc(C(=O)NNC(=O)c2ccc(C(=O)N(C)C)cc2)cc1,benzene ring
153661,Please add a hydroxyl to the molecule CCOc1cc(C(=O)NCc2c(CC)nn(C)c2OC)ccn1.,CCOc1cc(C(=O)NCc2c(CC)nn(C)c2OC)ccn1,hydroxyl
242708,Please add a amide to the molecule CCOc1ccc(-c2cn3c4c(=O)n(C)c(=O)n(C)c4nc3n2-c2ccc(Cl)cc2)cc1.,CCOc1ccc(-c2cn3c4c(=O)n(C)c(=O)n(C)c4nc3n2-c2ccc(Cl)cc2)cc1,amide
83331,Please add a amide to the molecule Cc1nc2c3ccccc3nc(SCC(=O)N(C)[C@@H](C)CC(C)C)n2n1.,Cc1nc2c3ccccc3nc(SCC(=O)N(C)[C@@H](C)CC(C)C)n2n1,amide
244493,Please add a hydroxyl to the molecule Cc1nn([C@@H](C)C(=O)Nc2cccc([N+](=O)[O-])c2)c(C)c1[N+](=O)[O-].,Cc1nn([C@@H](C)C(=O)Nc2cccc([N+](=O)[O-])c2)c(C)c1[N+](=O)[O-],hydroxyl
246501,Please add a benzene ring to the molecule O=C(c1cc(Cl)ccc1Cl)c1ccccc1C[N+]1=CCCC1.,O=C(c1cc(Cl)ccc1Cl)c1ccccc1C[N+]1=CCCC1,benzene ring
242543,Add a nitro to the molecule O=C(CNC(=O)Nc1ccc(Oc2ccccc2)cc1)NC1CC1.,O=C(CNC(=O)Nc1ccc(Oc2ccccc2)cc1)NC1CC1,nitro
192102,Add a benzene ring to the molecule O=C(Cc1cccnc1)N1CCCC[C@H]1c1cccc(F)c1.,O=C(Cc1cccnc1)N1CCCC[C@H]1c1cccc(F)c1,benzene ring
32843,Add a benzene ring to the molecule Cn1c(C(C)(C)C)nc2cc(NC(=O)C(=O)NCC3(C4CC4)CC3)ccc21.,Cn1c(C(C)(C)C)nc2cc(NC(=O)C(=O)NCC3(C4CC4)CC3)ccc21,benzene ring
173428,Add a amine to the molecule CC(=O)Nc1ccc(C(=O)[C@@H](C)Sc2ncccn2)cc1.,CC(=O)Nc1ccc(C(=O)[C@@H](C)Sc2ncccn2)cc1,amine
196802,Add a amide to the molecule O=C1N[C@H](c2ccc(F)c(-c3cccs3)c2)N2CCOC[C@@H]12.,O=C1N[C@H](c2ccc(F)c(-c3cccs3)c2)N2CCOC[C@@H]12,amide
29911,Modify the molecule COc1ccc2c(C)c(C(=O)N3CCc4cc(OC)c(OC)cc4C3)oc2c1 by adding a halo.,COc1ccc2c(C)c(C(=O)N3CCc4cc(OC)c(OC)cc4C3)oc2c1,halo
14580,Modify the molecule NS(=O)(=O)c1ccc(NC(=O)NCCc2c(F)cccc2F)cc1 by adding a amide.,NS(=O)(=O)c1ccc(NC(=O)NCCc2c(F)cccc2F)cc1,amide
16593,Please add a benzene ring to the molecule CN(CCC(N)=S)C(=O)COc1cccc2ccccc12.,CN(CCC(N)=S)C(=O)COc1cccc2ccccc12,benzene ring
45662,Modify the molecule O=C1NCCN(C(=O)C[C@@H]2C=CCC2)[C@H]1c1cccc(F)c1 by adding a benzene ring.,O=C1NCCN(C(=O)C[C@@H]2C=CCC2)[C@H]1c1cccc(F)c1,benzene ring
90622,Please add a amine to the molecule Cc1ccc(NC(=O)N[C@@H](C)c2ccc(C#N)cc2)c(Cl)c1.,Cc1ccc(NC(=O)N[C@@H](C)c2ccc(C#N)cc2)c(Cl)c1,amine
186135,Please add a hydroxyl to the molecule COc1ccccc1N1CCN(C(=O)c2nc(C)sc2-c2ccccc2)CC1.,COc1ccccc1N1CCN(C(=O)c2nc(C)sc2-c2ccccc2)CC1,hydroxyl
55479,Please add a benzene ring to the molecule O=C(Cc1cccc2cccnc12)N1CCOC[C@@H]1C1CC1.,O=C(Cc1cccc2cccnc12)N1CCOC[C@@H]1C1CC1,benzene ring
40044,Please add a hydroxyl to the molecule CC(C)c1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1.,CC(C)c1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1,hydroxyl
75329,Please add a hydroxyl to the molecule CCOC(=O)/C(=N/O)c1csc(N)n1.,CCOC(=O)/C(=N/O)c1csc(N)n1,hydroxyl
248783,Please add a amide to the molecule COc1ccc(Cl)cc1CCNC(=O)NCCc1cccnc1.,COc1ccc(Cl)cc1CCNC(=O)NCCc1cccnc1,amide
117963,Please add a benzene ring to the molecule CCSc1nnc(S[C@H](C)C(=O)N(C)Cc2ccccc2C)s1.,CCSc1nnc(S[C@H](C)C(=O)N(C)Cc2ccccc2C)s1,benzene ring
183807,Add a amine to the molecule C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1.,C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1,amine
951,Please add a benzene ring to the molecule Cc1cc(C)c2c(-c3ccccc3)nc(SCC(=O)NC3CC3)n2n1.,Cc1cc(C)c2c(-c3ccccc3)nc(SCC(=O)NC3CC3)n2n1,benzene ring
128740,Add a benzene ring to the molecule C[S@](=O)c1ccccc1NC(=O)C[C@@H]1OCCc2ccccc21.,C[S@](=O)c1ccccc1NC(=O)C[C@@H]1OCCc2ccccc21,benzene ring
194840,Modify the molecule COCC[C@H](C)C(=O)Nc1cccc(C(=O)N2CCOCC2)c1 by adding a benzene ring.,COCC[C@H](C)C(=O)Nc1cccc(C(=O)N2CCOCC2)c1,benzene ring
80050,Add a hydroxyl to the molecule CCOc1cc(/C=N/N2C(=O)[C@H]3[C@@H]4C=C[C@H]([C@@H]3C2=O)[C@@H]2C[C@H]42)cc(Cl)c1O.,CCOc1cc(/C=N/N2C(=O)[C@H]3[C@@H]4C=C[C@H]([C@@H]3C2=O)[C@@H]2C[C@H]42)cc(Cl)c1O,hydroxyl
170772,Please add a benzene ring to the molecule Cc1ccc2oc(C(=O)N3CCC(Cc4ncncc4C(=O)NC4CCCC4)CC3)cc2c1.,Cc1ccc2oc(C(=O)N3CCC(Cc4ncncc4C(=O)NC4CCCC4)CC3)cc2c1,benzene ring
22853,Modify the molecule CC(C)Oc1ccccc1CC(=O)N1C[C@@H](C)S[C@H](C)C1 by adding a halo.,CC(C)Oc1ccccc1CC(=O)N1C[C@@H](C)S[C@H](C)C1,halo
150576,Please add a halo to the molecule C[C@H](C(=O)N(C)Cc1nc2ccccc2s1)[NH+](C)CCS(C)(=O)=O.,C[C@H](C(=O)N(C)Cc1nc2ccccc2s1)[NH+](C)CCS(C)(=O)=O,halo
167546,Please add a hydroxyl to the molecule CC[C@@H](C(C)C)N1CCC(=O)N2CCCC[C@@H]2C1=O.,CC[C@@H](C(C)C)N1CCC(=O)N2CCCC[C@@H]2C1=O,hydroxyl
93866,Please add a hydroxyl to the molecule C1=C[C@@H]([NH+]2CCN(c3ncccn3)CC2)CCC1.,C1=C[C@@H]([NH+]2CCN(c3ncccn3)CC2)CCC1,hydroxyl
200763,Add a benzene ring to the molecule COCC[C@@H](C)C(=O)Nc1ccc(-n2ccnc2)c(F)c1.,COCC[C@@H](C)C(=O)Nc1ccc(-n2ccnc2)c(F)c1,benzene ring
100669,Modify the molecule COc1ccc(N2/C(=N/C(=O)C3CCCCC3)S[C@H]3CS(=O)(=O)C[C@H]32)c(OC)c1 by adding a hydroxyl.,COc1ccc(N2/C(=N/C(=O)C3CCCCC3)S[C@H]3CS(=O)(=O)C[C@H]32)c(OC)c1,hydroxyl
96025,Please add a benzene ring to the molecule Cc1cc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccccc2)CCCC4)no1.,Cc1cc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccccc2)CCCC4)no1,benzene ring
73435,Modify the molecule Cc1ccc(S(=O)(=O)NN=Cc2ccc(C(C)C)cc2)cc1 by adding a benzene ring.,Cc1ccc(S(=O)(=O)NN=Cc2ccc(C(C)C)cc2)cc1,benzene ring
17442,Modify the molecule COC(=O)[C@H]1CN(C(=O)CCOCC(F)(F)F)C[C@@H]1C by adding a amide.,COC(=O)[C@H]1CN(C(=O)CCOCC(F)(F)F)C[C@@H]1C,amide
81390,Please add a benzene ring to the molecule Cc1ccccc1[C@@H]1CN(C2CCSCC2)[C@H](C)CO1.,Cc1ccccc1[C@@H]1CN(C2CCSCC2)[C@H](C)CO1,benzene ring
118777,Add a hydroxyl to the molecule CO[C@@H]1CCCN(C(=O)c2ccc(-c3ccco3)[nH]c2=O)C1.,CO[C@@H]1CCCN(C(=O)c2ccc(-c3ccco3)[nH]c2=O)C1,hydroxyl
197480,Please add a aldehyde to the molecule CC[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccc(Br)cc1.,CC[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccc(Br)cc1,aldehyde
70011,Add a amide to the molecule CC[NH2+][C@H]1[C@H](N(C)Cc2cnn(C)c2)CCCC1(C)C.,CC[NH2+][C@H]1[C@H](N(C)Cc2cnn(C)c2)CCCC1(C)C,amide
134335,Please add a benzene ring to the molecule C/[NH+]=C(/NCc1cc(F)cc(Br)c1)N[C@H]1C[C@@H]1C.,C/[NH+]=C(/NCc1cc(F)cc(Br)c1)N[C@H]1C[C@@H]1C,benzene ring
148942,Add a amide to the molecule C[C@@]1(c2ccccc2)C[NH+]=C(N)N1C[C@@H]1CCCO1.,C[C@@]1(c2ccccc2)C[NH+]=C(N)N1C[C@@H]1CCCO1,amide
175256,Add a amide to the molecule CC(C)(C)c1ccc(OC[C@H](O)C[NH+]2CCC(CO)CC2)cc1.,CC(C)(C)c1ccc(OC[C@H](O)C[NH+]2CCC(CO)CC2)cc1,amide
118181,Add a halo to the molecule C=CCc1cc(-c2ccccc2)cc(C=O)c1OCC.,C=CCc1cc(-c2ccccc2)cc(C=O)c1OCC,halo
163403,Please add a benzene ring to the molecule COc1cccc2sc(NC(=O)Cc3ccc(C)cc3C)nc12.,COc1cccc2sc(NC(=O)Cc3ccc(C)cc3C)nc12,benzene ring
244387,Add a amide to the molecule C[C@@H](N)c1cc[nH+]c(N(C)C2CCCCCC2)c1.,C[C@@H](N)c1cc[nH+]c(N(C)C2CCCCCC2)c1,amide
181266,Add a hydroxyl to the molecule CN(CCOCC1CC1)C(=O)C(C)(C)CCl.,CN(CCOCC1CC1)C(=O)C(C)(C)CCl,hydroxyl
139828,Modify the molecule O=C(Nc1nnc(SCC(=O)N2CCCCC2)s1)c1ccc(F)cc1 by adding a aldehyde.,O=C(Nc1nnc(SCC(=O)N2CCCCC2)s1)c1ccc(F)cc1,aldehyde
9136,Add a benzene ring to the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCSC(C)(C)C1.,CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCSC(C)(C)C1,benzene ring
244559,Add a aldehyde to the molecule CN(C)C(=O)N1CCC(C(=O)Nc2ccc(N(C)C3CCCCC3)c(F)c2)CC1.,CN(C)C(=O)N1CCC(C(=O)Nc2ccc(N(C)C3CCCCC3)c(F)c2)CC1,aldehyde
182777,Please add a amide to the molecule O=C(NNc1cnccn1)Nc1ccccc1Cc1ccccc1.,O=C(NNc1cnccn1)Nc1ccccc1Cc1ccccc1,amide
122035,Add a aldehyde to the molecule CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O.,CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O,aldehyde
150693,Please add a thiol to the molecule O=C(COc1ccc(Br)cc1F)NC1CCCCC1.,O=C(COc1ccc(Br)cc1F)NC1CCCCC1,thiol
21159,Please add a benzene ring to the molecule CC(C)OC(=O)[C@H](C)CNC(=O)N1CCO[C@H](c2ccccc2Cl)C1.,CC(C)OC(=O)[C@H](C)CNC(=O)N1CCO[C@H](c2ccccc2Cl)C1,benzene ring
75957,Add a hydroxyl to the molecule O=CNc1ccc(C(=O)N[C@H]2CCCN(c3ccccc3Cl)C2)cc1.,O=CNc1ccc(C(=O)N[C@H]2CCCN(c3ccccc3Cl)C2)cc1,hydroxyl
39244,Please add a hydroxyl to the molecule COc1ccc(C[C@](C)(O)CNC(=O)C(=O)Nc2ccccc2F)cc1.,COc1ccc(C[C@](C)(O)CNC(=O)C(=O)Nc2ccccc2F)cc1,hydroxyl
65207,Please add a amide to the molecule C[NH+]1CCN(c2ccc(NC(=O)[C@@H](Sc3ccccc3)c3ccccc3)cc2)CC1.,C[NH+]1CCN(c2ccc(NC(=O)[C@@H](Sc3ccccc3)c3ccccc3)cc2)CC1,amide
242813,Modify the molecule C[C@H]1C[C@H](N)C[NH+](Cc2nnc(-c3cccs3)o2)C1 by adding a benzene ring.,C[C@H]1C[C@H](N)C[NH+](Cc2nnc(-c3cccs3)o2)C1,benzene ring
155243,Please add a hydroxyl to the molecule Cc1ccc2ncc(C(=O)Oc3cccc(N4CCCC4=O)c3)n2c1.,Cc1ccc2ncc(C(=O)Oc3cccc(N4CCCC4=O)c3)n2c1,hydroxyl
50618,Add a hydroxyl to the molecule CC(=O)N1CCN(C(=O)CSc2nc3ccccc3c(=O)n2[C@H]2CCC[C@@H](C)[C@H]2C)CC1.,CC(=O)N1CCN(C(=O)CSc2nc3ccccc3c(=O)n2[C@H]2CCC[C@@H](C)[C@H]2C)CC1,hydroxyl
125616,Add a benzene ring to the molecule O=C(Nc1cccc([C@H]2C=c3ccccc3=[NH+]2)c1)C1CCN(C(=O)C2=CCCC2)CC1.,O=C(Nc1cccc([C@H]2C=c3ccccc3=[NH+]2)c1)C1CCN(C(=O)C2=CCCC2)CC1,benzene ring
60765,Modify the molecule CCC[C@@H]([NH2+]C)[C@H](CC)N1C[C@@H]2CCC[NH+]2C[C@@H]1C by adding a amide.,CCC[C@@H]([NH2+]C)[C@H](CC)N1C[C@@H]2CCC[NH+]2C[C@@H]1C,amide
197495,Modify the molecule COC(=O)c1ccccc1NCC(=O)NCc1ccc2c(c1)OCO2 by adding a amide.,COC(=O)c1ccccc1NCC(=O)NCc1ccc2c(c1)OCO2,amide
13650,Modify the molecule CCOC(=O)[C@@H]1CCCN(C(=O)Cn2c(-c3cccs3)cc3ccccc32)C1 by adding a benzene ring.,CCOC(=O)[C@@H]1CCCN(C(=O)Cn2c(-c3cccs3)cc3ccccc32)C1,benzene ring
142209,Please add a amide to the molecule C[C@H](NCCc1ccc(F)cc1)c1nc2c(s1)CCCC2.,C[C@H](NCCc1ccc(F)cc1)c1nc2c(s1)CCCC2,amide
132748,Modify the molecule Cc1cc(F)cc(C(=O)N(C)C[C@H](O)CN2CCOCC2)c1 by adding a aldehyde.,Cc1cc(F)cc(C(=O)N(C)C[C@H](O)CN2CCOCC2)c1,aldehyde
139894,Modify the molecule O=C(NCc1cccnc1)c1n[nH]nc1Nc1ccc(Cl)cc1 by adding a amide.,O=C(NCc1cccnc1)c1n[nH]nc1Nc1ccc(Cl)cc1,amide
195586,Please add a amine to the molecule Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl.,Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl,amine
170796,Modify the molecule CCCN(CC(=O)NC)[C@@H]1CCC[NH+](Cc2ccccc2)C1 by adding a nitro.,CCCN(CC(=O)NC)[C@@H]1CCC[NH+](Cc2ccccc2)C1,nitro
216233,Please add a hydroxyl to the molecule O=C(CSc1ncnc2sc(-c3ccccc3)cc12)NC1CCCCC1.,O=C(CSc1ncnc2sc(-c3ccccc3)cc12)NC1CCCCC1,hydroxyl
148247,Add a carboxyl to the molecule CC[C@H]1C[NH+](CC2CCN(C(=O)OC(C)(C)C)CC2)CCS1.,CC[C@H]1C[NH+](CC2CCN(C(=O)OC(C)(C)C)CC2)CCS1,carboxyl
234165,Add a thiol to the molecule COc1ccccc1OC[C@H]1CN(C(=O)Cc2cccs2)CCO1.,COc1ccccc1OC[C@H]1CN(C(=O)Cc2cccs2)CCO1,thiol
206519,Please add a amide to the molecule Cc1ccc(N2CCC[C@H](NC(=O)NCc3ccc(Cl)nc3)C2)cc1.,Cc1ccc(N2CCC[C@H](NC(=O)NCc3ccc(Cl)nc3)C2)cc1,amide
32237,Modify the molecule COC(=O)c1ccc(C(=O)N2CCCCC[C@H]2c2cccn2C)nc1 by adding a amide.,COC(=O)c1ccc(C(=O)N2CCCCC[C@H]2c2cccn2C)nc1,amide
145567,Please add a aldehyde to the molecule C[C@H]([NH2+]Cc1ccc(F)cc1)c1cc(F)ccc1O.,C[C@H]([NH2+]Cc1ccc(F)cc1)c1cc(F)ccc1O,aldehyde
25557,Please add a hydroxyl to the molecule CCOCCN(C)C(=O)C(=O)Nc1ccc(C)nc1.,CCOCCN(C)C(=O)C(=O)Nc1ccc(C)nc1,hydroxyl
186731,Modify the molecule CC[NH2+]C/C(=C\c1ccc2ccccc2c1)C(C)C by adding a benzene ring.,CC[NH2+]C/C(=C\c1ccc2ccccc2c1)C(C)C,benzene ring
58909,Please add a benzene ring to the molecule N#Cc1ccccc1Cn1cccc1C(=O)[O-].,N#Cc1ccccc1Cn1cccc1C(=O)[O-],benzene ring
149988,Please add a benzene ring to the molecule C[C@H]1CN(C(=O)Cn2cc(SCC(=O)Nc3ccc(F)cc3)c3ccccc32)C[C@H](C)O1.,C[C@H]1CN(C(=O)Cn2cc(SCC(=O)Nc3ccc(F)cc3)c3ccccc32)C[C@H](C)O1,benzene ring
44407,Please add a halo to the molecule CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1.,CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1,halo
88538,Add a benzene ring to the molecule CCN1CCN(C(=O)[C@H]2Cc3cc(S(=O)(=O)N(CC)CC)ccc3N2C(C)=O)CC1.,CCN1CCN(C(=O)[C@H]2Cc3cc(S(=O)(=O)N(CC)CC)ccc3N2C(C)=O)CC1,benzene ring
132228,Please add a carboxyl to the molecule O=Cc1cnccc1-c1cccc(Br)c1.,O=Cc1cnccc1-c1cccc(Br)c1,carboxyl
223694,Please add a hydroxyl to the molecule CN1C[C@H](C(=O)N2CCN(C(=O)c3ccccc3)CC2)CC1=O.,CN1C[C@H](C(=O)N2CCN(C(=O)c3ccccc3)CC2)CC1=O,hydroxyl
236155,Modify the molecule CCCOc1ccc([C@H]2C[NH+]=C(N)N2C(C)C)cc1 by adding a hydroxyl.,CCCOc1ccc([C@H]2C[NH+]=C(N)N2C(C)C)cc1,hydroxyl
189356,Add a hydroxyl to the molecule CC(C)(C)c1cc(C(=O)Oc2ccc3c(c2)OCCO3)[nH]n1.,CC(C)(C)c1cc(C(=O)Oc2ccc3c(c2)OCCO3)[nH]n1,hydroxyl
12066,Modify the molecule [NH3+]CC1CCC(C(=O)N[C@@H]2CONC2=O)CC1 by adding a benzene ring.,[NH3+]CC1CCC(C(=O)N[C@@H]2CONC2=O)CC1,benzene ring
73196,Please add a benzene ring to the molecule CCN(CC)C(=O)CCC(=O)N1CCCN(C(N)=O)CC1.,CCN(CC)C(=O)CCC(=O)N1CCCN(C(N)=O)CC1,benzene ring
191545,Add a hydroxyl to the molecule Cc1cc(C)n2c(SCc3ccccc3)nnc2c1.,Cc1cc(C)n2c(SCc3ccccc3)nnc2c1,hydroxyl
53472,Add a aldehyde to the molecule CCC[C@@H](C)NC(=O)[C@H](C)Oc1ccc2c(C)cc(=O)oc2c1.,CCC[C@@H](C)NC(=O)[C@H](C)Oc1ccc2c(C)cc(=O)oc2c1,aldehyde
107911,Modify the molecule O=C(COC(=O)COc1ccccc1)Nc1cc2c(cc1Cl)C(=O)c1ccccc1C2=O by adding a benzene ring.,O=C(COC(=O)COc1ccccc1)Nc1cc2c(cc1Cl)C(=O)c1ccccc1C2=O,benzene ring
79464,Modify the molecule CCOc1cc(/C=C2/SC(=O)N(CC(=O)Nc3ccccc3)C2=O)ccc1O by adding a benzene ring.,CCOc1cc(/C=C2/SC(=O)N(CC(=O)Nc3ccccc3)C2=O)ccc1O,benzene ring
187468,Please add a hydroxyl to the molecule COCC1CCN(C(=O)NC[C@H]2CC[C@H](C(=O)[O-])O2)CC1.,COCC1CCN(C(=O)NC[C@H]2CC[C@H](C(=O)[O-])O2)CC1,hydroxyl
33126,Modify the molecule NC(=O)[C@H]1CCC[C@@H]([NH2+][C@H]2CCc3sc(Cl)cc32)C1 by adding a aldehyde.,NC(=O)[C@H]1CCC[C@@H]([NH2+][C@H]2CCc3sc(Cl)cc32)C1,aldehyde
75482,Add a aldehyde to the molecule C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1.,C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1,aldehyde
183114,Please add a hydroxyl to the molecule CC[C@@H](C)Nc1ncnc2c1oc1ccccc12.,CC[C@@H](C)Nc1ncnc2c1oc1ccccc12,hydroxyl
119792,Modify the molecule Cc1cnc(N2CCNC(=O)[C@H]2C(C)C)c([N+](=O)[O-])c1 by adding a amine.,Cc1cnc(N2CCNC(=O)[C@H]2C(C)C)c([N+](=O)[O-])c1,amine
65295,Modify the molecule O=C(NC[C@H]1CCCO1)C1=CC2=c3ccccc3=[NH+][C@H]2C(c2ccc(F)cc2)=N1 by adding a benzene ring.,O=C(NC[C@H]1CCCO1)C1=CC2=c3ccccc3=[NH+][C@H]2C(c2ccc(F)cc2)=N1,benzene ring
135292,Please add a hydroxyl to the molecule C[C@H](NC(=O)c1ccoc1)C(=O)Nc1ccc([C@@]2(C)NC(=O)NC2=O)cc1.,C[C@H](NC(=O)c1ccoc1)C(=O)Nc1ccc([C@@]2(C)NC(=O)NC2=O)cc1,hydroxyl
75493,Modify the molecule CCc1noc(CN(C)C(=O)NCC2(c3ccc(Cl)cc3)CC2)n1 by adding a amine.,CCc1noc(CN(C)C(=O)NCC2(c3ccc(Cl)cc3)CC2)n1,amine
195954,Please add a carboxyl to the molecule CC[C@H](NC(=O)C1CCCC1)c1ccc(OC)cc1.,CC[C@H](NC(=O)C1CCCC1)c1ccc(OC)cc1,carboxyl
232366,Please add a carboxyl to the molecule C#CCN1C(=O)[C@@]2(C(C#N)=C(N)Nc3nc(SCc4cccc(F)c4)[nH]c(=O)c32)c2ccccc21.,C#CCN1C(=O)[C@@]2(C(C#N)=C(N)Nc3nc(SCc4cccc(F)c4)[nH]c(=O)c32)c2ccccc21,carboxyl
34001,Modify the molecule CN/C(=[NH+]\C)SCC(=O)N1CC[C@@H](C)Sc2ccccc21 by adding a hydroxyl.,CN/C(=[NH+]\C)SCC(=O)N1CC[C@@H](C)Sc2ccccc21,hydroxyl
159866,Modify the molecule CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1 by adding a hydroxyl.,CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1,hydroxyl
217589,Add a hydroxyl to the molecule CC(C)CN(C(=O)C[NH+]1CCC(C(=O)Nc2ccccc2)CC1)C1CC1.,CC(C)CN(C(=O)C[NH+]1CCC(C(=O)Nc2ccccc2)CC1)C1CC1,hydroxyl
71655,Modify the molecule COc1ccc(N2C(=O)CSC23CCN(S(=O)(=O)c2ccc(OC)cc2)CC3)cc1 by adding a aldehyde.,COc1ccc(N2C(=O)CSC23CCN(S(=O)(=O)c2ccc(OC)cc2)CC3)cc1,aldehyde
60362,Modify the molecule CC[C@@](C)(O)c1cccc(OC(C)C)c1 by adding a benzene ring.,CC[C@@](C)(O)c1cccc(OC(C)C)c1,benzene ring
237434,Please add a benzene ring to the molecule Cc1ccc(C(=O)N(C)C)cc1N[C@H]1CC[NH2+]C1.,Cc1ccc(C(=O)N(C)C)cc1N[C@H]1CC[NH2+]C1,benzene ring
146638,Add a benzene ring to the molecule Cc1cc(C(=O)N2CCC(C)CC2)ccc1NC(=O)N1CCC[C@@H]1c1cccn1C.,Cc1cc(C(=O)N2CCC(C)CC2)ccc1NC(=O)N1CCC[C@@H]1c1cccn1C,benzene ring
29014,Modify the molecule C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1 by adding a amide.,C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1,amide
213529,Modify the molecule COCCNC(=S)N[C@@H]1CCCc2ccccc21 by adding a aldehyde.,COCCNC(=S)N[C@@H]1CCCc2ccccc21,aldehyde
77277,Add a halo to the molecule Cc1nn(C)cc1-c1cc(-c2cnn(-c3ccccc3F)c2)nc(N)c1C#N.,Cc1nn(C)cc1-c1cc(-c2cnn(-c3ccccc3F)c2)nc(N)c1C#N,halo
169684,Modify the molecule CC1CC[NH+](CCNC(=O)[C@@H]2SCCc3sccc32)CC1 by adding a hydroxyl.,CC1CC[NH+](CCNC(=O)[C@@H]2SCCc3sccc32)CC1,hydroxyl
209388,Add a hydroxyl to the molecule CC[NH+](CC)Cc1ccc(C[NH2+]C(C)C)cc1.,CC[NH+](CC)Cc1ccc(C[NH2+]C(C)C)cc1,hydroxyl
159897,Please add a benzene ring to the molecule COCc1ccc(C/[NH+]=C/c2ccccc2O)cc1.,COCc1ccc(C/[NH+]=C/c2ccccc2O)cc1,benzene ring
26867,Please add a thiol to the molecule Cc1cc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)on1.,Cc1cc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)on1,thiol
178441,Add a hydroxyl to the molecule O=C(NCC(F)(F)F)[C@@H]1CCC[NH+](CC2=Cc3ccccc3OC2)C1.,O=C(NCC(F)(F)F)[C@@H]1CCC[NH+](CC2=Cc3ccccc3OC2)C1,hydroxyl
95249,Modify the molecule CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1 by adding a benzene ring.,CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1,benzene ring
196084,Add a halo to the molecule [NH3+]C[C@@H]1CN(Cc2cccn2-c2ccc(Cl)cn2)CCO1.,[NH3+]C[C@@H]1CN(Cc2cccn2-c2ccc(Cl)cn2)CCO1,halo
200439,Add a hydroxyl to the molecule Cc1ccccc1NC(=O)c1sc(-c2ccsc2)nc1C.,Cc1ccccc1NC(=O)c1sc(-c2ccsc2)nc1C,hydroxyl
153033,Add a aldehyde to the molecule Cc1cc(C)n2nc(C(=O)NC[C@H](C)Oc3ccccc3Cl)nc2n1.,Cc1cc(C)n2nc(C(=O)NC[C@H](C)Oc3ccccc3Cl)nc2n1,aldehyde
76938,Please add a hydroxyl to the molecule CN(CCC(F)(F)F)c1cc[nH+]c2ccsc12.,CN(CCC(F)(F)F)c1cc[nH+]c2ccsc12,hydroxyl
183943,Modify the molecule NC(=O)[C@H]1COCCN1C(=O)Cc1csc(-c2cccc(F)c2)n1 by adding a amide.,NC(=O)[C@H]1COCCN1C(=O)Cc1csc(-c2cccc(F)c2)n1,amide
67929,Please add a amide to the molecule O=C(NCc1cccc(OCC(F)F)n1)N[C@@H]1[C@@H]2CCO[C@@H]2C12CCC2.,O=C(NCc1cccc(OCC(F)F)n1)N[C@@H]1[C@@H]2CCO[C@@H]2C12CCC2,amide
78223,Modify the molecule C[C@H]1COCCN1C(=O)NCc1cc2ccccc2o1 by adding a aldehyde.,C[C@H]1COCCN1C(=O)NCc1cc2ccccc2o1,aldehyde
61385,Add a amide to the molecule O=C(Nc1cccc2cccnc12)C1(c2cc(-c3ccccc3)on2)CC1.,O=C(Nc1cccc2cccnc12)C1(c2cc(-c3ccccc3)on2)CC1,amide
109459,Add a benzene ring to the molecule COc1ccccc1C(=O)N[C@H](C(=O)Nc1ccc2ncccc2c1)C(C)C.,COc1ccccc1C(=O)N[C@H](C(=O)Nc1ccc2ncccc2c1)C(C)C,benzene ring
198643,Modify the molecule Cc1c(C(=O)Nc2ccc(F)cc2)nnn1-c1cccc(Cl)c1 by adding a amide.,Cc1c(C(=O)Nc2ccc(F)cc2)nnn1-c1cccc(Cl)c1,amide
223721,Add a amide to the molecule C1CC(C[NH+]2C[C@H]3CC[C@@H]2CN(Cc2nnc(C4CC4)o2)C3)C1.,C1CC(C[NH+]2C[C@H]3CC[C@@H]2CN(Cc2nnc(C4CC4)o2)C3)C1,amide
81185,Please add a benzene ring to the molecule COc1ccc(OC)c(CN2CCN(c3nc(C)nc4c3CC[NH2+]C4)CC2)c1.,COc1ccc(OC)c(CN2CCN(c3nc(C)nc4c3CC[NH2+]C4)CC2)c1,benzene ring
240898,Add a amide to the molecule [NH2+]=C1NC[C@H]([C@@H]2CCOC2)N1c1ccc(Cl)c(Br)c1.,[NH2+]=C1NC[C@H]([C@@H]2CCOC2)N1c1ccc(Cl)c(Br)c1,amide
121020,Please add a nitro to the molecule COc1cccc(C(=O)Nc2cc(CN3CCOCC3)ccc2C)c1F.,COc1cccc(C(=O)Nc2cc(CN3CCOCC3)ccc2C)c1F,nitro
50371,Please add a benzene ring to the molecule Cc1cc(NC(=O)CNC(=O)c2ccc([O-])nn2)no1.,Cc1cc(NC(=O)CNC(=O)c2ccc([O-])nn2)no1,benzene ring
180411,Modify the molecule CCCn1cc[nH+]c1CN1CCN2C(=O)CN(C)C(=O)[C@@H]2C1 by adding a amide.,CCCn1cc[nH+]c1CN1CCN2C(=O)CN(C)C(=O)[C@@H]2C1,amide
111474,Add a hydroxyl to the molecule CC[C@@H](C)C(=O)Nc1ccccc1O.,CC[C@@H](C)C(=O)Nc1ccccc1O,hydroxyl
76527,Please add a nitrile to the molecule OCc1ccc(OCCC2OCCCO2)cc1.,OCc1ccc(OCCC2OCCCO2)cc1,nitrile
191869,Please add a aldehyde to the molecule CCOC(=O)N1CCN(C(=O)COc2ccc(S(=O)(=O)N3CCCCC3)cc2)CC1.,CCOC(=O)N1CCN(C(=O)COc2ccc(S(=O)(=O)N3CCCCC3)cc2)CC1,aldehyde
217079,Please add a nitro to the molecule Cc1ccc(C(=O)N2N=C(C(F)(F)F)C[C@]2(O)C(C)(C)C)cc1.,Cc1ccc(C(=O)N2N=C(C(F)(F)F)C[C@]2(O)C(C)(C)C)cc1,nitro
31755,Modify the molecule COc1c(Br)cc(C[NH2+]Cc2ccco2)cc1Br by adding a nitro.,COc1c(Br)cc(C[NH2+]Cc2ccco2)cc1Br,nitro
129871,Add a amide to the molecule CC(C)CCOc1cccc(N2C[C@H]([NH3+])CC2=O)c1.,CC(C)CCOc1cccc(N2C[C@H]([NH3+])CC2=O)c1,amide
62384,Add a halo to the molecule CCN(CC)c1nc(C)cc(C(=O)N(C)Cc2ccco2)n1.,CCN(CC)c1nc(C)cc(C(=O)N(C)Cc2ccco2)n1,halo
161771,Add a nitro to the molecule CCCc1[o+]cc(-c2ccccc2)c2c1CCCC2.,CCCc1[o+]cc(-c2ccccc2)c2c1CCCC2,nitro
144928,Modify the molecule CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21 by adding a hydroxyl.,CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21,hydroxyl
75825,Add a amine to the molecule COC[C@@H](O)C[NH+]1CCC(N[C@H]2CCOc3ccc(C)c(C)c32)CC1.,COC[C@@H](O)C[NH+]1CCC(N[C@H]2CCOc3ccc(C)c(C)c32)CC1,amine
57983,Please add a nitro to the molecule COc1ccc(C(=O)N2CCCSc3ccccc32)nn1.,COc1ccc(C(=O)N2CCCSc3ccccc32)nn1,nitro
201232,Modify the molecule O=C(NCCc1ccccn1)NCc1cccc(NC(=O)[C@H]2CCCO2)c1 by adding a amide.,O=C(NCCc1ccccn1)NCc1cccc(NC(=O)[C@H]2CCCO2)c1,amide
156763,Modify the molecule CC[C@@H](Oc1ccc2c(c1)CCC2)C(=O)Nc1ccn(CC#N)n1 by adding a amine.,CC[C@@H](Oc1ccc2c(c1)CCC2)C(=O)Nc1ccn(CC#N)n1,amine
131793,Add a amine to the molecule CCOc1ccc2nc(S[C@@H](C)[C@@H](C)C(=O)NN)[nH]c2c1.,CCOc1ccc2nc(S[C@@H](C)[C@@H](C)C(=O)NN)[nH]c2c1,amine
66325,Modify the molecule CCc1nc(C(=O)Nc2ccc(S(=O)(=O)CC)cc2)n[nH]1 by adding a hydroxyl.,CCc1nc(C(=O)Nc2ccc(S(=O)(=O)CC)cc2)n[nH]1,hydroxyl
13500,Please add a benzene ring to the molecule Cc1cc(C#CCCO)ccc1OCc1ccc(O)cc1.,Cc1cc(C#CCCO)ccc1OCc1ccc(O)cc1,benzene ring
219552,Please add a amine to the molecule CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]12C.,CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)[C@@H](O)C[C@@]12C,amine
197097,Add a benzene ring to the molecule CCc1cc2c(Nc3ccncc3)ncnc2s1.,CCc1cc2c(Nc3ccncc3)ncnc2s1,benzene ring
8311,Modify the molecule CN(Cc1cc(Cl)cc(Cl)c1)C(=O)c1cccc(C[S@@](C)=O)c1 by adding a hydroxyl.,CN(Cc1cc(Cl)cc(Cl)c1)C(=O)c1cccc(C[S@@](C)=O)c1,hydroxyl
56340,Add a amide to the molecule CCNc1cccc(CN2CC[C@@H](c3ccccc3)C2)[nH+]1.,CCNc1cccc(CN2CC[C@@H](c3ccccc3)C2)[nH+]1,amide
53169,Please add a hydroxyl to the molecule C#CCNC(=O)CN1C(=O)N[C@@](C)(CCC)C1=O.,C#CCNC(=O)CN1C(=O)N[C@@](C)(CCC)C1=O,hydroxyl
51965,Add a hydroxyl to the molecule CCOC(=O)CCc1c(C)c2cc3c(c(C)c2oc1=O)OC[NH+]([C@@H](C)CC)C3.,CCOC(=O)CCc1c(C)c2cc3c(c(C)c2oc1=O)OC[NH+]([C@@H](C)CC)C3,hydroxyl
106645,Modify the molecule Cc1cccc(N2CCN(C(=O)COc3ccc(S(=O)(=O)Nc4ccccc4)cc3)CC2)c1C by adding a benzene ring.,Cc1cccc(N2CCN(C(=O)COc3ccc(S(=O)(=O)Nc4ccccc4)cc3)CC2)c1C,benzene ring
190868,Please add a benzene ring to the molecule CCO[C@H](C)c1noc(C[NH+]2C[C@H](C)C[C@@H]2c2cccc(F)c2)n1.,CCO[C@H](C)c1noc(C[NH+]2C[C@H](C)C[C@@H]2c2cccc(F)c2)n1,benzene ring
15955,Please add a aldehyde to the molecule CCC1CCC([NH2+][C@H](C)[C@@H]2CN(C)CCO2)CC1.,CCC1CCC([NH2+][C@H](C)[C@@H]2CN(C)CCO2)CC1,aldehyde
37829,Please add a benzene ring to the molecule COc1cccc(-c2nnc3ccc(OCCNC(=O)c4cc5ccccc5o4)nn23)c1.,COc1cccc(-c2nnc3ccc(OCCNC(=O)c4cc5ccccc5o4)nn23)c1,benzene ring
196634,Please add a amine to the molecule O=c1ncn(CCc2c[nH]c3ccccc23)cc1-c1ncc(C(F)(F)F)cc1Cl.,O=c1ncn(CCc2c[nH]c3ccccc23)cc1-c1ncc(C(F)(F)F)cc1Cl,amine
245100,Modify the molecule CCn1cc(C(=O)N(C)[C@@H](C)c2ccncc2)cn1 by adding a hydroxyl.,CCn1cc(C(=O)N(C)[C@@H](C)c2ccncc2)cn1,hydroxyl
75455,Add a hydroxyl to the molecule Cc1ccc(NC(=O)[C@H]2C[C@H]2c2cccc(F)c2)cc1N1CCOC1=O.,Cc1ccc(NC(=O)[C@H]2C[C@H]2c2cccc(F)c2)cc1N1CCOC1=O,hydroxyl
27376,Add a benzene ring to the molecule CCC[NH+](CC)Cc1ccc(C(=O)OC)cn1.,CCC[NH+](CC)Cc1ccc(C(=O)OC)cn1,benzene ring
113281,Modify the molecule COc1cccc(NC(=O)Nc2ccc(N3CCCS3(=O)=O)cc2)c1 by adding a benzene ring.,COc1cccc(NC(=O)Nc2ccc(N3CCCS3(=O)=O)cc2)c1,benzene ring
79651,Please add a benzene ring to the molecule COc1ccc(C[NH+](C)CCS(C)(=O)=O)cc1/C(N)=N/O.,COc1ccc(C[NH+](C)CCS(C)(=O)=O)cc1/C(N)=N/O,benzene ring
125380,Modify the molecule CNc1ccc(Cl)cc1C(=O)NCC1C(C)(C)C1(C)C by adding a hydroxyl.,CNc1ccc(Cl)cc1C(=O)NCC1C(C)(C)C1(C)C,hydroxyl
190714,Please add a benzene ring to the molecule Cc1ccccc1C(=O)N(CC(=O)N1CCc2sccc2[C@@H]1COc1ccccc1)C(C)C.,Cc1ccccc1C(=O)N(CC(=O)N1CCc2sccc2[C@@H]1COc1ccccc1)C(C)C,benzene ring
156587,Add a aldehyde to the molecule CSC[C@@H](C)C(=O)NC[C@H](c1ccc(C)cc1)[NH+](C)C.,CSC[C@@H](C)C(=O)NC[C@H](c1ccc(C)cc1)[NH+](C)C,aldehyde
180814,Please add a amine to the molecule C[C@H]1Oc2ccc(NC(=O)N(Cc3cccnc3)C[C@@H]3CCCO3)cc2NC1=O.,C[C@H]1Oc2ccc(NC(=O)N(Cc3cccnc3)C[C@@H]3CCCO3)cc2NC1=O,amine
92338,Please add a benzene ring to the molecule O=Cc1cccc(OCC(=O)NCc2nnc3ccccn23)c1.,O=Cc1cccc(OCC(=O)NCc2nnc3ccccn23)c1,benzene ring
157094,Please add a amide to the molecule CCOC(=O)c1sc(NC(=O)Nc2ccc(Cl)cc2)c(C#N)c1C.,CCOC(=O)c1sc(NC(=O)Nc2ccc(Cl)cc2)c(C#N)c1C,amide
43324,Add a benzene ring to the molecule CC(=O)N[C@@H](CC(C)C)C(=O)N1CCC(n2cc(CO)nn2)CC1.,CC(=O)N[C@@H](CC(C)C)C(=O)N1CCC(n2cc(CO)nn2)CC1,benzene ring
20618,Modify the molecule O=C(NCCc1nc(NC2CC2)ncc1C(=O)N1CCCC1)[C@@H]1CCCO1 by adding a amine.,O=C(NCCc1nc(NC2CC2)ncc1C(=O)N1CCCC1)[C@@H]1CCCO1,amine
76302,Modify the molecule COC(=O)C1(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CCCC1 by adding a amide.,COC(=O)C1(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CCCC1,amide
198925,Modify the molecule COc1ccc([C@@H]2C[C@@H](c3ccc(C)c(C)c3)Nc3ncnn32)c(OC)c1OC by adding a halo.,COc1ccc([C@@H]2C[C@@H](c3ccc(C)c(C)c3)Nc3ncnn32)c(OC)c1OC,halo
74704,Add a amine to the molecule CNC(=O)Cc1ccc(NC(=O)NC)cc1.,CNC(=O)Cc1ccc(NC(=O)NC)cc1,amine
125148,Modify the molecule C#CCNC(=O)NCc1ccccc1C[NH+]1CCCC[C@H]1C by adding a hydroxyl.,C#CCNC(=O)NCc1ccccc1C[NH+]1CCCC[C@H]1C,hydroxyl
86152,Modify the molecule O=S(=O)(c1ccc(F)cc1)N1CCN=C1SCc1c(F)cccc1Cl by adding a amide.,O=S(=O)(c1ccc(F)cc1)N1CCN=C1SCc1c(F)cccc1Cl,amide
187095,Please add a thiol to the molecule COCCCN1C(=O)c2cccc3cc(NC(C)=O)cc(c23)C1=O.,COCCCN1C(=O)c2cccc3cc(NC(C)=O)cc(c23)C1=O,thiol
88890,Add a halo to the molecule C/C(=N\NC(=S)[C@H]1COc2ccccc2O1)[C@H]1COc2ccccc2O1.,C/C(=N\NC(=S)[C@H]1COc2ccccc2O1)[C@H]1COc2ccccc2O1,halo
212911,Add a hydroxyl to the molecule Cc1cc(CNC(=O)CN2CC[NH+](Cc3ccccn3)CC2)ccc1F.,Cc1cc(CNC(=O)CN2CC[NH+](Cc3ccccn3)CC2)ccc1F,hydroxyl
206456,Modify the molecule CC1=C(C(=O)Nc2ccc(Cl)cc2)[C@H](c2cnn(Cc3ccccc3)c2)NC(=S)N1 by adding a benzene ring.,CC1=C(C(=O)Nc2ccc(Cl)cc2)[C@H](c2cnn(Cc3ccccc3)c2)NC(=S)N1,benzene ring
30157,Please add a nitro to the molecule COc1cc2c(cc1OC)[C@@H]1CCCC[C@@H]1O[C@H]2c1cccc(NS(C)(=O)=O)c1.,COc1cc2c(cc1OC)[C@@H]1CCCC[C@@H]1O[C@H]2c1cccc(NS(C)(=O)=O)c1,nitro
127931,Add a benzene ring to the molecule O=C(NCCCO)NCCc1cccc2ccccc12.,O=C(NCCCO)NCCc1cccc2ccccc12,benzene ring
48809,Please add a hydroxyl to the molecule Cc1c(Cl)cccc1NC(=O)[C@@H](C)N1C(=O)[C@@H]2[C@H](C1=O)[C@@H]1C=C[C@H]2[C@@H]2C[C@H]12.,Cc1c(Cl)cccc1NC(=O)[C@@H](C)N1C(=O)[C@@H]2[C@H](C1=O)[C@@H]1C=C[C@H]2[C@@H]2C[C@H]12,hydroxyl
19399,Please add a benzene ring to the molecule C[NH+](CC(=O)N[C@@H]1CCS(=O)(=O)C1)Cc1cccc(Cl)c1Cl.,C[NH+](CC(=O)N[C@@H]1CCS(=O)(=O)C1)Cc1cccc(Cl)c1Cl,benzene ring
176496,Modify the molecule CC(C)NC(=O)CNC(=O)c1ccc([N+](=O)[O-])cc1Cl by adding a nitro.,CC(C)NC(=O)CNC(=O)c1ccc([N+](=O)[O-])cc1Cl,nitro
88147,Please add a halo to the molecule O=C(CN1C(=O)C[C@@H](c2ccco2)S(=O)(=O)c2ccccc21)Nc1ccc(Cl)c(Cl)c1.,O=C(CN1C(=O)C[C@@H](c2ccco2)S(=O)(=O)c2ccccc21)Nc1ccc(Cl)c(Cl)c1,halo
19961,Add a hydroxyl to the molecule CC(=O)Nc1ccc(C(=O)Nc2nc(-c3c[nH]c4ccccc34)cs2)cc1.,CC(=O)Nc1ccc(C(=O)Nc2nc(-c3c[nH]c4ccccc34)cs2)cc1,hydroxyl
135457,Modify the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)C2CCN(S(=O)(=O)c3ccccc3)CC2)C1 by adding a amide.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)C2CCN(S(=O)(=O)c3ccccc3)CC2)C1,amide
146987,Add a aldehyde to the molecule CC(C)NC(=O)NC[C@H]1C[C@H]2CC[NH+]1C[C@@H]2C[NH+]1CCN(c2ccc(F)cc2)CC1.,CC(C)NC(=O)NC[C@H]1C[C@H]2CC[NH+]1C[C@@H]2C[NH+]1CCN(c2ccc(F)cc2)CC1,aldehyde
230006,Add a benzene ring to the molecule CN(C)c1ccc([C@@H](CNC(=O)C(=O)NC2CCCC2)N2CCOCC2)cc1.,CN(C)c1ccc([C@@H](CNC(=O)C(=O)NC2CCCC2)N2CCOCC2)cc1,benzene ring
16007,Modify the molecule CCN(CC(=O)NCc1ccc(F)cc1)C(=O)C1CCCCC1 by adding a halo.,CCN(CC(=O)NCc1ccc(F)cc1)C(=O)C1CCCCC1,halo
221036,Modify the molecule C[C@H]1C[NH2+]C(C)(C)CN1Cc1ccnc2ccccc12 by adding a benzene ring.,C[C@H]1C[NH2+]C(C)(C)CN1Cc1ccnc2ccccc12,benzene ring
193556,Add a nitro to the molecule CCSc1cncc(Sc2nnc(C3CC[NH2+]CC3)n2C(C)C)n1.,CCSc1cncc(Sc2nnc(C3CC[NH2+]CC3)n2C(C)C)n1,nitro
94883,Modify the molecule Cc1nccn1-c1cncc(N2CCN(c3cc[nH+]cc3Cl)CC2)n1 by adding a hydroxyl.,Cc1nccn1-c1cncc(N2CCN(c3cc[nH+]cc3Cl)CC2)n1,hydroxyl
20432,Modify the molecule CCOc1cc(C(=O)NC[C@@H](O)c2ccco2)ccc1OC by adding a hydroxyl.,CCOc1cc(C(=O)NC[C@@H](O)c2ccco2)ccc1OC,hydroxyl
220872,Add a hydroxyl to the molecule CCOc1ccc(C=O)cc1[C@H](C)CC.,CCOc1ccc(C=O)cc1[C@H](C)CC,hydroxyl
62492,Modify the molecule CCC[C@@H]1CN(C(=O)[C@@H]2Cc3cccc(F)c3O2)CCO1 by adding a amine.,CCC[C@@H]1CN(C(=O)[C@@H]2Cc3cccc(F)c3O2)CCO1,amine
212953,Modify the molecule COCCO[C@@H](C)C(=O)Nc1cccc(-c2nnn[n-]2)c1 by adding a hydroxyl.,COCCO[C@@H](C)C(=O)Nc1cccc(-c2nnn[n-]2)c1,hydroxyl
188680,Add a thiol to the molecule Clc1ccc(C2SCCCS2)c(Cl)c1.,Clc1ccc(C2SCCCS2)c(Cl)c1,thiol
61207,Add a halo to the molecule CC[C@H]1CCCCCN1C(=O)c1cccc(OC)c1F.,CC[C@H]1CCCCCN1C(=O)c1cccc(OC)c1F,halo
166451,Add a hydroxyl to the molecule C[C@@H](c1cc2ccccc2o1)N(C)C(=O)COc1ccc([N+](=O)[O-])c(F)c1.,C[C@@H](c1cc2ccccc2o1)N(C)C(=O)COc1ccc([N+](=O)[O-])c(F)c1,hydroxyl
181441,Please add a benzene ring to the molecule O=C1C(Br)=C[C@H]2[C@H]1[C@H]1C=C[C@]2(Br)C12OCCO2.,O=C1C(Br)=C[C@H]2[C@H]1[C@H]1C=C[C@]2(Br)C12OCCO2,benzene ring
236351,Add a nitro to the molecule C[C@H](CCCO)NC(=O)Cc1ccc(O)cc1.,C[C@H](CCCO)NC(=O)Cc1ccc(O)cc1,nitro
17836,Add a amine to the molecule COc1cc(C#N)ccc1OC(=O)/C=C/c1ccccc1.,COc1cc(C#N)ccc1OC(=O)/C=C/c1ccccc1,amine
71438,Please add a aldehyde to the molecule O=C(NCc1ccccc1)[C@@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(C(F)(F)F)c1.,O=C(NCc1ccccc1)[C@@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(C(F)(F)F)c1,aldehyde
168954,Please add a aldehyde to the molecule C[C@@H](c1ccccn1)[NH+](C)CC(=O)NCc1ccccc1[N+](=O)[O-].,C[C@@H](c1ccccn1)[NH+](C)CC(=O)NCc1ccccc1[N+](=O)[O-],aldehyde
245990,Add a hydroxyl to the molecule [NH3+][C@H]1CCCC[C@H]1Nc1nc2c([N+](=O)[O-])cccc2o1.,[NH3+][C@H]1CCCC[C@H]1Nc1nc2c([N+](=O)[O-])cccc2o1,hydroxyl
137572,Modify the molecule Cc1ccc(/N=C/c2ccc3c(c2)OCO3)cc1 by adding a thiol.,Cc1ccc(/N=C/c2ccc3c(c2)OCO3)cc1,thiol
148322,Modify the molecule Cc1ccc(NC(=O)Nc2ccncc2)cc1 by adding a benzene ring.,Cc1ccc(NC(=O)Nc2ccncc2)cc1,benzene ring
179150,Modify the molecule CC(C)[NH+]1CCCN(CN2C(=O)[C@H]3CCC[C@H]32)CC1 by adding a halo.,CC(C)[NH+]1CCCN(CN2C(=O)[C@H]3CCC[C@H]32)CC1,halo
4275,Please add a amide to the molecule C[C@H](C(=O)NCc1ccccc1)N1CCN(Cc2ccc(Cl)cc2)CC1.,C[C@H](C(=O)NCc1ccccc1)N1CCN(Cc2ccc(Cl)cc2)CC1,amide
28725,Please add a hydroxyl to the molecule COc1ccc(C)cc1Nc1ncnc(-n2cnc3ccccc32)c1[N+](=O)[O-].,COc1ccc(C)cc1Nc1ncnc(-n2cnc3ccccc32)c1[N+](=O)[O-],hydroxyl
137021,Add a amine to the molecule O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccccc1.,O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccccc1,amine
105670,Please add a amide to the molecule C[C@H](Oc1ccc(F)cc1)C(=O)N1CCN(c2ncc3c(n2)CCOC3)CC1.,C[C@H](Oc1ccc(F)cc1)C(=O)N1CCN(c2ncc3c(n2)CCOC3)CC1,amide
205526,Add a hydroxyl to the molecule Cc1cc(N2CCOCC2)nc(Nc2ccc(NC(=O)c3ccccc3Cl)cc2)[nH+]1.,Cc1cc(N2CCOCC2)nc(Nc2ccc(NC(=O)c3ccccc3Cl)cc2)[nH+]1,hydroxyl
168531,Modify the molecule COc1ccc2c(Cl)c(C(=O)Nc3cccc([N+](=O)[O-])c3)sc2c1 by adding a benzene ring.,COc1ccc2c(Cl)c(C(=O)Nc3cccc([N+](=O)[O-])c3)sc2c1,benzene ring
165425,Modify the molecule Cc1nc2cc(NC(=O)[C@@H]3CC34CCN(C(=O)[C@H]3CC(=O)c5ccccc53)CC4)ccc2s1 by adding a halo.,Cc1nc2cc(NC(=O)[C@@H]3CC34CCN(C(=O)[C@H]3CC(=O)c5ccccc53)CC4)ccc2s1,halo
146549,Modify the molecule COc1ccc2nc(N3CC(C(=O)N4CCN(CCc5ccccc5)CC4)C3)sc2c1 by adding a benzene ring.,COc1ccc2nc(N3CC(C(=O)N4CCN(CCc5ccccc5)CC4)C3)sc2c1,benzene ring
75528,Add a amide to the molecule Cc1ccc([C@@H](C)NC(=O)N[C@H]2CCC[C@@]2(C)CO)o1.,Cc1ccc([C@@H](C)NC(=O)N[C@H]2CCC[C@@]2(C)CO)o1,amide
1407,Please add a benzene ring to the molecule C[C@H](CCc1ccccc1F)[NH2+]CCc1nc2cc(F)ccc2n1C.,C[C@H](CCc1ccccc1F)[NH2+]CCc1nc2cc(F)ccc2n1C,benzene ring
193001,Add a halo to the molecule Cc1c(F)cccc1NC(=O)C(=O)NCC(C)(C)[NH2+][C@H](C)c1ccccc1.,Cc1c(F)cccc1NC(=O)C(=O)NCC(C)(C)[NH2+][C@H](C)c1ccccc1,halo
118717,Please add a amide to the molecule O=C1[C@H](NCc2cccc(O)c2)CCN1Cc1ccccc1.,O=C1[C@H](NCc2cccc(O)c2)CCN1Cc1ccccc1,amide
124972,Modify the molecule CCc1nc(-c2cc(C)cc3c2O[C@@H](C[NH3+])C3)ncc1C by adding a amine.,CCc1nc(-c2cc(C)cc3c2O[C@@H](C[NH3+])C3)ncc1C,amine
176608,Add a nitro to the molecule CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CC[S@](=O)C(C)(C)C1.,CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CC[S@](=O)C(C)(C)C1,nitro
118077,Add a amine to the molecule O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1.,O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1,amine
35764,Modify the molecule NC(=O)c1ccsc1NC(=O)COC(=O)c1ccc(Cl)nc1 by adding a benzene ring.,NC(=O)c1ccsc1NC(=O)COC(=O)c1ccc(Cl)nc1,benzene ring
170613,Add a hydroxyl to the molecule Cn1ccc(Nc2cc(C(F)(F)F)nc(-c3ccccn3)n2)n1.,Cn1ccc(Nc2cc(C(F)(F)F)nc(-c3ccccn3)n2)n1,hydroxyl
138965,Add a amide to the molecule CC[NH+]1CCC[C@@H](NCc2ccc(C3CC3)cc2)C1.,CC[NH+]1CCC[C@@H](NCc2ccc(C3CC3)cc2)C1,amide
102089,Add a hydroxyl to the molecule N#Cc1c(NC(=O)c2cc(F)ccc2Br)sc2c1CCC2.,N#Cc1c(NC(=O)c2cc(F)ccc2Br)sc2c1CCC2,hydroxyl
18551,Modify the molecule CCOc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2c2cccc(C)n2)cc1OC by adding a amine.,CCOc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2c2cccc(C)n2)cc1OC,amine
50631,Please add a amine to the molecule O=C([C@H]1CC(=O)N(C2CCCCCCC2)C1)N1CCC2(CC1)OCCO2.,O=C([C@H]1CC(=O)N(C2CCCCCCC2)C1)N1CCC2(CC1)OCCO2,amine
124191,Modify the molecule COCc1cccc(C(=O)N2CCSC(C)(C)C2)c1 by adding a hydroxyl.,COCc1cccc(C(=O)N2CCSC(C)(C)C2)c1,hydroxyl
246844,Please add a benzene ring to the molecule CSC[C@H](C)C(=O)Nc1nc2ccc(C)cc2s1.,CSC[C@H](C)C(=O)Nc1nc2ccc(C)cc2s1,benzene ring
127705,Add a hydroxyl to the molecule CN1CCO[C@@H](CN2C(=O)c3cc(N)ccc3S2(=O)=O)C1.,CN1CCO[C@@H](CN2C(=O)c3cc(N)ccc3S2(=O)=O)C1,hydroxyl
78695,Add a halo to the molecule Cc1nc(-n2cccc2)sc1C(=O)N1CCN(c2ccccc2Cl)CC1.,Cc1nc(-n2cccc2)sc1C(=O)N1CCN(c2ccccc2Cl)CC1,halo
116445,Add a halo to the molecule Cc1c(Cl)cccc1/N=C1\NN=C(c2ccc3c(c2)C[C@H](C)N3S(C)(=O)=O)CS1.,Cc1c(Cl)cccc1/N=C1\NN=C(c2ccc3c(c2)C[C@H](C)N3S(C)(=O)=O)CS1,halo
150907,Modify the molecule COc1ccc(O)c([C@H](C)NC(=O)N[C@H](c2nc(C)cs2)C2CC2)c1 by adding a hydroxyl.,COc1ccc(O)c([C@H](C)NC(=O)N[C@H](c2nc(C)cs2)C2CC2)c1,hydroxyl
161304,Add a halo to the molecule O=C(Nc1cc(Cl)ccc1F)N1CCCC[C@@H]1CO.,O=C(Nc1cc(Cl)ccc1F)N1CCCC[C@@H]1CO,halo
233394,Modify the molecule Fc1ccc(-c2noc(CCCn3ccnn3)n2)c(Cl)c1 by adding a amide.,Fc1ccc(-c2noc(CCCn3ccnn3)n2)c(Cl)c1,amide
10746,Add a benzene ring to the molecule C[C@@H](CC(=O)NCCc1c[nH]c2ccccc12)NC(=O)c1ccccc1.,C[C@@H](CC(=O)NCCc1c[nH]c2ccccc12)NC(=O)c1ccccc1,benzene ring
227944,Modify the molecule CN(C)C(=O)c1cccc(NC(=O)C(=O)NCc2ccc(-n3cccn3)cc2)c1 by adding a benzene ring.,CN(C)C(=O)c1cccc(NC(=O)C(=O)NCc2ccc(-n3cccn3)cc2)c1,benzene ring
151462,Modify the molecule C[C@H](Cn1cccn1)C(=O)N1CCc2c(nc(-c3ccccn3)[nH]c2=O)C1 by adding a nitrile.,C[C@H](Cn1cccn1)C(=O)N1CCc2c(nc(-c3ccccn3)[nH]c2=O)C1,nitrile
151717,Add a amine to the molecule COc1ccccc1NC(=O)N(CC[NH+]1CCCC1)Cc1cc2cc3c(cc2[nH]c1=O)OCO3.,COc1ccccc1NC(=O)N(CC[NH+]1CCCC1)Cc1cc2cc3c(cc2[nH]c1=O)OCO3,amine
101617,Please add a halo to the molecule Cc1ccc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)c(C)c1.,Cc1ccc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)c(C)c1,halo
41307,Add a aldehyde to the molecule COCCOC1CCN(C(=O)C(C)(C)c2cccc(Cl)c2)CC1.,COCCOC1CCN(C(=O)C(C)(C)c2cccc(Cl)c2)CC1,aldehyde
50974,Please add a carboxyl to the molecule CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1.,CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1,carboxyl
10876,Add a hydroxyl to the molecule O=C(CCN1CCCC1=O)N[C@H]1CC[NH+](CC2CCCC2)C1.,O=C(CCN1CCCC1=O)N[C@H]1CC[NH+](CC2CCCC2)C1,hydroxyl
22803,Modify the molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2ccc3c(c2)ncn3-c2ccccc2)C1 by adding a nitro.,CCOC(=O)[C@@H]1CCCN(C(=O)c2ccc3c(c2)ncn3-c2ccccc2)C1,nitro
159170,Modify the molecule C[NH2+][C@@H]1[C@H](Sc2nc(C)cc(C)n2)CCC1(C)C by adding a benzene ring.,C[NH2+][C@@H]1[C@H](Sc2nc(C)cc(C)n2)CCC1(C)C,benzene ring
59327,Modify the molecule Cc1ccc2c(c1)CCN2C(=O)c1ccn(C2CCCC2)n1 by adding a nitro.,Cc1ccc2c(c1)CCN2C(=O)c1ccn(C2CCCC2)n1,nitro
219339,Please add a amide to the molecule CCOc1ccc(C(=O)N2c3ccccc3C[C@H]2C(N)=O)cc1OCC.,CCOc1ccc(C(=O)N2c3ccccc3C[C@H]2C(N)=O)cc1OCC,amide
63385,Please add a amide to the molecule COc1ccccc1NC(=O)NC[C@@H](c1ccc2c(c1)CCCN2C)[NH+](C)C.,COc1ccccc1NC(=O)NC[C@@H](c1ccc2c(c1)CCCN2C)[NH+](C)C,amide
86147,Add a amine to the molecule CCC(CC)N1C[C@@]23C=C[C@@H](O2)[C@@H](C(=O)N2CCNC(=O)C2)[C@@H]3C1=O.,CCC(CC)N1C[C@@]23C=C[C@@H](O2)[C@@H](C(=O)N2CCNC(=O)C2)[C@@H]3C1=O,amine
236278,Modify the molecule O=C(Cn1ccnc1)N1CCC[C@@H](c2nc(-c3cccs3)cc(=O)[nH]2)C1 by adding a benzene ring.,O=C(Cn1ccnc1)N1CCC[C@@H](c2nc(-c3cccs3)cc(=O)[nH]2)C1,benzene ring
66170,Add a hydroxyl to the molecule CN(c1nc2ccccc2n2c(C3CCCCC3)nnc12)S(=O)(=O)c1ccccc1.,CN(c1nc2ccccc2n2c(C3CCCCC3)nnc12)S(=O)(=O)c1ccccc1,hydroxyl
230650,Add a benzene ring to the molecule O=C(NCCc1cccc([N+](=O)[O-])c1)c1cc2ccccc2c(=O)[nH]1.,O=C(NCCc1cccc([N+](=O)[O-])c1)c1cc2ccccc2c(=O)[nH]1,benzene ring
16051,Add a carboxyl to the molecule Cc1noc([C@@H]2CCCN2C(=O)c2cccc([N+](=O)[O-])c2C)n1.,Cc1noc([C@@H]2CCCN2C(=O)c2cccc([N+](=O)[O-])c2C)n1,carboxyl
155242,Modify the molecule CCOc1ccc(NC(=O)N2CC(=O)N3CCc4ccccc4[C@H]3C2)cc1 by adding a nitro.,CCOc1ccc(NC(=O)N2CC(=O)N3CCc4ccccc4[C@H]3C2)cc1,nitro
206181,Modify the molecule COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1 by adding a hydroxyl.,COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1,hydroxyl
78890,Modify the molecule C[C@@]1(C(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)Cc2ccccc2C(=O)O1 by adding a benzene ring.,C[C@@]1(C(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)Cc2ccccc2C(=O)O1,benzene ring
31406,Add a benzene ring to the molecule Cc1c(NC(=O)C(=O)N(C)Cc2ccc(N(C)C)cc2)cccc1[N+](=O)[O-].,Cc1c(NC(=O)C(=O)N(C)Cc2ccc(N(C)C)cc2)cccc1[N+](=O)[O-],benzene ring
247931,Add a benzene ring to the molecule CC(=O)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1.,CC(=O)[C@@H]1CCCN(C(=O)OC(C)(C)C)C1,benzene ring
51591,Please add a halo to the molecule Cc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CC3)CC2)cc1.,Cc1ccc(S(=O)(=O)NC2CCN(C(=O)C3CC3)CC2)cc1,halo
232387,Please add a amide to the molecule COc1cccc(C(=O)Nc2c(C)c(C)nn2-c2ccc(C#N)cc2)n1.,COc1cccc(C(=O)Nc2c(C)c(C)nn2-c2ccc(C#N)cc2)n1,amide
133030,Please add a halo to the molecule O=S(=O)(NC[C@H](c1cccnc1)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)cc1.,O=S(=O)(NC[C@H](c1cccnc1)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)cc1,halo
54735,Add a nitro to the molecule CS[C@H]1CCCC[NH+](Cc2ccc(OCc3c(C)noc3C)cc2)C1.,CS[C@H]1CCCC[NH+](Cc2ccc(OCc3c(C)noc3C)cc2)C1,nitro
73534,Add a hydroxyl to the molecule O=C(NCCc1csc2ccccc12)N[C@@H]1C=C[C@H](CO)C1.,O=C(NCCc1csc2ccccc12)N[C@@H]1C=C[C@H](CO)C1,hydroxyl
147167,Please add a halo to the molecule CC(C)C1CCC(C[NH3+])([C@@](C)(O)c2ccccc2Cl)CC1.,CC(C)C1CCC(C[NH3+])([C@@](C)(O)c2ccccc2Cl)CC1,halo
205612,Add a thiol to the molecule CCc1ccc(N2C(=O)CS[C@@H]2c2ccccc2F)cc1.,CCc1ccc(N2C(=O)CS[C@@H]2c2ccccc2F)cc1,thiol
198250,Modify the molecule Cn1cc[nH+]c1CCN[C@@H]1CC[C@H]([NH3+])C1 by adding a hydroxyl.,Cn1cc[nH+]c1CCN[C@@H]1CC[C@H]([NH3+])C1,hydroxyl
148988,Modify the molecule Cc1ccc(F)cc1CC(=O)N1CC[C@@](O)(C2CCOCC2)[C@H](C)C1 by adding a amide.,Cc1ccc(F)cc1CC(=O)N1CC[C@@](O)(C2CCOCC2)[C@H](C)C1,amide
91441,Modify the molecule COc1ccc([C@@](C)(O)[C@@H]2CCCN2C(=O)Nc2cccnc2Cl)cc1 by adding a amine.,COc1ccc([C@@](C)(O)[C@@H]2CCCN2C(=O)Nc2cccnc2Cl)cc1,amine
5736,Add a benzene ring to the molecule CC[C@H]1C(=O)NCCN1C(=O)[C@@H](C)Oc1cc(Cl)cc(Cl)c1.,CC[C@H]1C(=O)NCCN1C(=O)[C@@H](C)Oc1cc(Cl)cc(Cl)c1,benzene ring
126789,Add a hydroxyl to the molecule C[C@H]1CCCN(S(=O)(=O)c2ccc(CNc3cncc(-n4cccn4)n3)cc2)C1.,C[C@H]1CCCN(S(=O)(=O)c2ccc(CNc3cncc(-n4cccn4)n3)cc2)C1,hydroxyl
31412,Add a halo to the molecule O=C(/C=C/c1ccccc1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1.,O=C(/C=C/c1ccccc1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1,halo
67319,Modify the molecule CCc1noc(CN(CC)C(=O)c2ccc(Cn3nc(C)cc3C)cc2)n1 by adding a nitro.,CCc1noc(CN(CC)C(=O)c2ccc(Cn3nc(C)cc3C)cc2)n1,nitro
87912,Modify the molecule COc1ccccc1[C@H]([NH3+])[C@H]1CCOC2(CCCCC2)C1 by adding a benzene ring.,COc1ccccc1[C@H]([NH3+])[C@H]1CCOC2(CCCCC2)C1,benzene ring
88074,Add a amine to the molecule CS[C@H]1CCC[C@H]1NC(=O)N(C)Cc1ccc([S@](C)=O)cc1.,CS[C@H]1CCC[C@H]1NC(=O)N(C)Cc1ccc([S@](C)=O)cc1,amine
120506,Please add a nitro to the molecule COc1cccc(/C(C)=C/C(=O)OCc2csc(-c3ccccn3)n2)c1.,COc1cccc(/C(C)=C/C(=O)OCc2csc(-c3ccccn3)n2)c1,nitro
243146,Add a nitro to the molecule C[C@@H]1CCC[C@@]([C@H]([NH3+])Cc2ccc(F)cc2Cl)([NH+](C)C)C1.,C[C@@H]1CCC[C@@]([C@H]([NH3+])Cc2ccc(F)cc2Cl)([NH+](C)C)C1,nitro
89521,Add a hydroxyl to the molecule COC[C@H](C)NC(=O)NC[C@@H](C)C[C@@H](C)O.,COC[C@H](C)NC(=O)NC[C@@H](C)C[C@@H](C)O,hydroxyl
18346,Please add a benzene ring to the molecule CCc1cnc2c(c1SCC(=O)OC)c(=O)n(C)c(=O)n2C.,CCc1cnc2c(c1SCC(=O)OC)c(=O)n(C)c(=O)n2C,benzene ring
10101,Modify the molecule Cc1nnsc1C(=O)NCCc1ccccc1 by adding a hydroxyl.,Cc1nnsc1C(=O)NCCc1ccccc1,hydroxyl
141272,Please add a hydroxyl to the molecule CC[C@H]1CC[C@@H](Nc2ccc(C(N)=O)cn2)[C@@H]1C.,CC[C@H]1CC[C@@H](Nc2ccc(C(N)=O)cn2)[C@@H]1C,hydroxyl
137484,Add a benzene ring to the molecule CCOc1ccc2[nH]c(=O)c([C@@H](c3nnnn3Cc3ccccc3)[NH+]3CCc4ccccc4C3)cc2c1.,CCOc1ccc2[nH]c(=O)c([C@@H](c3nnnn3Cc3ccccc3)[NH+]3CCc4ccccc4C3)cc2c1,benzene ring
150360,Add a benzene ring to the molecule Cc1ccc([C@H](CNC(=O)N[C@@H](C)c2nncn2C)[NH+](C)C)cc1.,Cc1ccc([C@H](CNC(=O)N[C@@H](C)c2nncn2C)[NH+](C)C)cc1,benzene ring
159904,Add a benzene ring to the molecule CC[NH+]1CCN([C@@H]2CCN(Cc3c(C)nn(C)c3OC)C2)CC1.,CC[NH+]1CCN([C@@H]2CCN(Cc3c(C)nn(C)c3OC)C2)CC1,benzene ring
122608,Please add a nitro to the molecule Cc1ccc(/C=C2\C(=O)N(c3cccc(Br)c3)C(=O)N=C2[O-])cc1[N+](=O)[O-].,Cc1ccc(/C=C2\C(=O)N(c3cccc(Br)c3)C(=O)N=C2[O-])cc1[N+](=O)[O-],nitro
61366,Please add a amide to the molecule Cc1cc(N)nc(SCC(=O)N(C2CC2)[C@@H]2CCS(=O)(=O)C2)n1.,Cc1cc(N)nc(SCC(=O)N(C2CC2)[C@@H]2CCS(=O)(=O)C2)n1,amide
147791,Modify the molecule O=C(NC[C@H](O)c1c(F)cccc1F)c1cc(F)ccc1F by adding a hydroxyl.,O=C(NC[C@H](O)c1c(F)cccc1F)c1cc(F)ccc1F,hydroxyl
163890,Please add a amide to the molecule Cc1cc(=O)n2nc(NCCCN3C[C@@H](C)O[C@H](C)C3)sc2n1.,Cc1cc(=O)n2nc(NCCCN3C[C@@H](C)O[C@H](C)C3)sc2n1,amide
38674,Please add a halo to the molecule C[C@@H]([NH2+][C@@H]1CC[C@H]([NH+](C)C)C1)[C@H](C)c1ccccc1.,C[C@@H]([NH2+][C@@H]1CC[C@H]([NH+](C)C)C1)[C@H](C)c1ccccc1,halo
238758,Modify the molecule CC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3c(C)nc4ccccn34)[C@H]2c2ccccc2F)nc1C by adding a hydroxyl.,CC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3c(C)nc4ccccn34)[C@H]2c2ccccc2F)nc1C,hydroxyl
38097,Please add a benzene ring to the molecule Cc1ccc(CN2C(=O)CC[C@H]2C(=O)NC2CCCC2)cc1.,Cc1ccc(CN2C(=O)CC[C@H]2C(=O)NC2CCCC2)cc1,benzene ring
71207,Add a benzene ring to the molecule CCC[C@H]1[C@H](C)CCCN1C(=O)CCS(=O)(=O)c1ccc(C)cc1.,CCC[C@H]1[C@H](C)CCCN1C(=O)CCS(=O)(=O)c1ccc(C)cc1,benzene ring
246028,Add a amide to the molecule CC[NH+](CC(=O)N[C@H](C)c1ccc(F)cc1)[C@@H](C)C(C)C.,CC[NH+](CC(=O)N[C@H](C)c1ccc(F)cc1)[C@@H](C)C(C)C,amide
25371,Please add a hydroxyl to the molecule CCC[C@@H](C#N)NC(=O)COc1cc(Cl)cc(Cl)c1.,CCC[C@@H](C#N)NC(=O)COc1cc(Cl)cc(Cl)c1,hydroxyl
185223,Modify the molecule Cc1cc(C)n(-c2ccc(CNC(=O)N3CC[C@@H](C)[C@H](O)C3)cn2)n1 by adding a amide.,Cc1cc(C)n(-c2ccc(CNC(=O)N3CC[C@@H](C)[C@H](O)C3)cn2)n1,amide
189697,Please add a hydroxyl to the molecule O=c1[nH]c2ccccc2nc1/C=C/c1cccc(F)c1.,O=c1[nH]c2ccccc2nc1/C=C/c1cccc(F)c1,hydroxyl
150235,Modify the molecule Cc1ccccc1-n1c(CCl)nc2ccsc2c1=O by adding a hydroxyl.,Cc1ccccc1-n1c(CCl)nc2ccsc2c1=O,hydroxyl
249222,Add a hydroxyl to the molecule Cc1cc(CN2CCN(S(=O)(=O)N(C)CCC#N)CC2)no1.,Cc1cc(CN2CCN(S(=O)(=O)N(C)CCC#N)CC2)no1,hydroxyl
231259,Add a halo to the molecule COc1ccccc1C[C@H]1CCCN(C(=O)[C@H]2CCCO2)C1.,COc1ccccc1C[C@H]1CCCN(C(=O)[C@H]2CCCO2)C1,halo
100801,Add a amide to the molecule CONC(=O)C1(c2ccccc2Cl)CCOCC1.,CONC(=O)C1(c2ccccc2Cl)CCOCC1,amide
60861,Add a thiol to the molecule COC[C@H](C)OC(=O)c1c(N)n(Cc2ccccc2)c2nc3ccccc3nc12.,COC[C@H](C)OC(=O)c1c(N)n(Cc2ccccc2)c2nc3ccccc3nc12,thiol
109373,Modify the molecule CNc1ncc(F)c(-c2cnn(C)c2)n1 by adding a amide.,CNc1ncc(F)c(-c2cnn(C)c2)n1,amide
36893,Add a nitro to the molecule COc1ccccc1C[C@@H](C)C[NH3+].,COc1ccccc1C[C@@H](C)C[NH3+],nitro
140040,Add a hydroxyl to the molecule O=C(Nc1cc(Cl)cc(Cl)c1)C(=S)NC1CCCCC1.,O=C(Nc1cc(Cl)cc(Cl)c1)C(=S)NC1CCCCC1,hydroxyl
167262,Modify the molecule O=C(NCC[NH+]1CCCCC1)N1CCC(OCc2ccccc2)CC1 by adding a amide.,O=C(NCC[NH+]1CCCCC1)N1CCC(OCc2ccccc2)CC1,amide
89283,Please add a benzene ring to the molecule Cc1ccc(NC(=O)c2ccn(-c3cccc(Cl)c3)n2)c(Br)c1.,Cc1ccc(NC(=O)c2ccn(-c3cccc(Cl)c3)n2)c(Br)c1,benzene ring
171300,Modify the molecule C[C@@H](c1cccc(Cl)c1)[NH+](C)Cc1ccc(Br)cc1N by adding a benzene ring.,C[C@@H](c1cccc(Cl)c1)[NH+](C)Cc1ccc(Br)cc1N,benzene ring
12453,Add a amide to the molecule COc1ccc(CNC(=O)c2cccc(C)c2[N+](=O)[O-])cc1.,COc1ccc(CNC(=O)c2cccc(C)c2[N+](=O)[O-])cc1,amide
242522,Add a hydroxyl to the molecule Cc1cc(S(=O)(=O)Nc2cccc3cccnc23)ccc1Br.,Cc1cc(S(=O)(=O)Nc2cccc3cccnc23)ccc1Br,hydroxyl
101402,Add a carboxyl to the molecule COc1ccc([C@H]2c3[nH]c4ccccc4c3CC[NH+]2Cc2cnn(C)c2)cc1C.,COc1ccc([C@H]2c3[nH]c4ccccc4c3CC[NH+]2Cc2cnn(C)c2)cc1C,carboxyl
190989,Add a aldehyde to the molecule C[C@@H]1CN(C)c2ccccc2CN1C(=O)NCC(C)(C)N1CCOCC1.,C[C@@H]1CN(C)c2ccccc2CN1C(=O)NCC(C)(C)N1CCOCC1,aldehyde
93847,Add a amide to the molecule CN(C)C(=O)C[C@@H]([NH2+]C[C@@H]1CCCO1)C(N)=O.,CN(C)C(=O)C[C@@H]([NH2+]C[C@@H]1CCCO1)C(N)=O,amide
49171,Modify the molecule CC(C)[C@@H]1CCC[C@H]([NH+](CC2CC[NH2+]CC2)C2CC2)CC1 by adding a benzene ring.,CC(C)[C@@H]1CCC[C@H]([NH+](CC2CC[NH2+]CC2)C2CC2)CC1,benzene ring
34971,Add a thiol to the molecule Cc1cc(C)cc(C[S@@](=O)[C@@H](C)CC#N)c1.,Cc1cc(C)cc(C[S@@](=O)[C@@H](C)CC#N)c1,thiol
27130,Add a hydroxyl to the molecule CC(C)(C)OC1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1.,CC(C)(C)OC1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1,hydroxyl
125811,Modify the molecule CC(C)CNC(=O)NC[C@@H](C)[NH+]1CCc2sccc2C1 by adding a benzene ring.,CC(C)CNC(=O)NC[C@@H](C)[NH+]1CCc2sccc2C1,benzene ring
165445,Add a benzene ring to the molecule CC[C@@H]([NH2+][C@@H](C)[C@@H]1CN(C)CCO1)c1ccccc1OC(F)F.,CC[C@@H]([NH2+][C@@H](C)[C@@H]1CN(C)CCO1)c1ccccc1OC(F)F,benzene ring
208956,Add a benzene ring to the molecule CCN(CC(C)(C)O)C(=O)c1cc(N2CCCC2=O)cc(C(F)(F)F)c1.,CCN(CC(C)(C)O)C(=O)c1cc(N2CCCC2=O)cc(C(F)(F)F)c1,benzene ring
76052,Add a benzene ring to the molecule COC1CC[NH+](CCC(=O)Nc2ccc(F)c(N)c2)CC1.,COC1CC[NH+](CCC(=O)Nc2ccc(F)c(N)c2)CC1,benzene ring
127938,Add a amine to the molecule CC[C@@H]1CCC[C@H](NC(=O)Nc2cccc(NC(C)=O)c2)C1.,CC[C@@H]1CCC[C@H](NC(=O)Nc2cccc(NC(C)=O)c2)C1,amine
210077,Add a aldehyde to the molecule Cc1ccc(CN(C)C(=O)c2cccc(CN3C(=O)CSC3=O)c2)o1.,Cc1ccc(CN(C)C(=O)c2cccc(CN3C(=O)CSC3=O)c2)o1,aldehyde
46312,Add a nitro to the molecule Cc1nn(CCO)c(C)c1C[NH+]1CCC[C@H](CCC(C)C)C1.,Cc1nn(CCO)c(C)c1C[NH+]1CCC[C@H](CCC(C)C)C1,nitro
246471,Add a amide to the molecule Cc1cc(C)n(-c2ccc(NCC[S@@](=O)Cc3ccccc3)nn2)n1.,Cc1cc(C)n(-c2ccc(NCC[S@@](=O)Cc3ccccc3)nn2)n1,amide
4516,Please add a benzene ring to the molecule COc1ccc(C[NH+]2CC[C@]3(O)CCCC[C@@H]3C2)cc1O.,COc1ccc(C[NH+]2CC[C@]3(O)CCCC[C@@H]3C2)cc1O,benzene ring
70024,Please add a halo to the molecule COc1ccc(NC(=O)[C@H]2N=NC3=C2CCc2ccccc23)cc1OC.,COc1ccc(NC(=O)[C@H]2N=NC3=C2CCc2ccccc23)cc1OC,halo
8558,Add a benzene ring to the molecule COc1ccccc1CNC(=O)c1nn(C)c(=O)c2ccccc12.,COc1ccccc1CNC(=O)c1nn(C)c(=O)c2ccccc12,benzene ring
215593,Please add a amide to the molecule CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1.,CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1,amide
227041,Modify the molecule C[C@H](NC(=O)Nc1cccc(CS(C)(=O)=O)c1)c1ccc(Cl)cc1 by adding a carboxyl.,C[C@H](NC(=O)Nc1cccc(CS(C)(=O)=O)c1)c1ccc(Cl)cc1,carboxyl
201299,Please add a benzene ring to the molecule C[C@@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1ccccc1-n1cncn1.,C[C@@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1ccccc1-n1cncn1,benzene ring
138034,Add a carboxyl to the molecule COc1cc(C)ccc1OS(=O)(=O)c1cccc(Cl)c1.,COc1cc(C)ccc1OS(=O)(=O)c1cccc(Cl)c1,carboxyl
96039,Add a benzene ring to the molecule COC(=O)[C@]1(N)CCC[C@@H](Oc2ccccc2CO)C1.,COC(=O)[C@]1(N)CCC[C@@H](Oc2ccccc2CO)C1,benzene ring
119743,Please add a hydroxyl to the molecule CC[C@@H]([NH3+])Cc1ccccc1OC[C@@H]1CN(CC)CCO1.,CC[C@@H]([NH3+])Cc1ccccc1OC[C@@H]1CN(CC)CCO1,hydroxyl
232014,Please add a benzene ring to the molecule CCOCC[NH2+]Cc1ccc([S@](C)=O)cc1.,CCOCC[NH2+]Cc1ccc([S@](C)=O)cc1,benzene ring
119357,Modify the molecule CCc1ccc(-c2nc(CC(=O)N[C@@H](C)c3ccncc3)cs2)cc1 by adding a aldehyde.,CCc1ccc(-c2nc(CC(=O)N[C@@H](C)c3ccncc3)cs2)cc1,aldehyde
37783,Please add a halo to the molecule Cc1ccc([C@H](NC(=O)C(=O)Nc2ccc(C(=O)NC3CC3)cc2)C2CC2)cc1.,Cc1ccc([C@H](NC(=O)C(=O)Nc2ccc(C(=O)NC3CC3)cc2)C2CC2)cc1,halo
52372,Add a hydroxyl to the molecule C[C@@H]1CCC[C@H]1[NH2+]Cc1cc(F)ccc1CS(C)(=O)=O.,C[C@@H]1CCC[C@H]1[NH2+]Cc1cc(F)ccc1CS(C)(=O)=O,hydroxyl
178809,Modify the molecule O=C(CNC(=O)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2)NC1CC1 by adding a benzene ring.,O=C(CNC(=O)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2)NC1CC1,benzene ring
97409,Add a benzene ring to the molecule C[C@H](NC(=O)c1cccc(S(C)(=O)=O)c1)c1ccc2c(c1)OCO2.,C[C@H](NC(=O)c1cccc(S(C)(=O)=O)c1)c1ccc2c(c1)OCO2,benzene ring
102608,Modify the molecule CC(=O)N1CC[C@H](CN(C)C(=O)CCCn2ccc3cc(Cl)ccc32)C1 by adding a halo.,CC(=O)N1CC[C@H](CN(C)C(=O)CCCn2ccc3cc(Cl)ccc32)C1,halo
67448,Modify the molecule C[C@H]1C[C@@H]1CN(C)C(=O)c1cc(C(F)(F)F)ccc1NN by adding a amide.,C[C@H]1C[C@@H]1CN(C)C(=O)c1cc(C(F)(F)F)ccc1NN,amide
159653,Modify the molecule COC(=O)C[C@@H](C)SC[C@@H]1CSc2ccccc21 by adding a benzene ring.,COC(=O)C[C@@H](C)SC[C@@H]1CSc2ccccc21,benzene ring
26160,Add a amide to the molecule COc1cc(C)c(I)c(C)c1C#N.,COc1cc(C)c(I)c(C)c1C#N,amide
378,Modify the molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 by adding a halo.,CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2,halo
92503,Add a amide to the molecule Cc1ccccc1NC(=S)N(Cc1ccncc1)Cc1ccco1.,Cc1ccccc1NC(=S)N(Cc1ccncc1)Cc1ccco1,amide
205932,Please add a benzene ring to the molecule COCCN1C(N)=[NH+]C[C@H]1c1ccc(C)cc1.,COCCN1C(N)=[NH+]C[C@H]1c1ccc(C)cc1,benzene ring
30546,Please add a amide to the molecule C=CCc1cc(C(=O)CC)ccc1OC.,C=CCc1cc(C(=O)CC)ccc1OC,amide
98001,Please add a hydroxyl to the molecule CC1CCC(CNC(=O)NCc2ccc(C(=O)[O-])o2)CC1.,CC1CCC(CNC(=O)NCc2ccc(C(=O)[O-])o2)CC1,hydroxyl
175317,Please add a benzene ring to the molecule CCCC[C@]1(c2ccc(F)cc2)NC(=O)N(CN2CC[NH+]([C@H]3CCS(=O)(=O)C3)CC2)C1=O.,CCCC[C@]1(c2ccc(F)cc2)NC(=O)N(CN2CC[NH+]([C@H]3CCS(=O)(=O)C3)CC2)C1=O,benzene ring
110168,Add a halo to the molecule O=C(NCc1ccc(S(=O)(=O)N2CCCC2)s1)c1ccc(Cl)cc1.,O=C(NCc1ccc(S(=O)(=O)N2CCCC2)s1)c1ccc(Cl)cc1,halo
225861,Add a carboxyl to the molecule COC(=O)c1c(NC(=O)c2oc3ccc(OC)cc3c2C)sc(C)c1C.,COC(=O)c1c(NC(=O)c2oc3ccc(OC)cc3c2C)sc(C)c1C,carboxyl
180430,Please add a hydroxyl to the molecule CC(C)(COc1cc(F)c([N+](=O)[O-])cc1F)C(=O)NN.,CC(C)(COc1cc(F)c([N+](=O)[O-])cc1F)C(=O)NN,hydroxyl
87547,Modify the molecule O=C([O-])CCCc1nc2cc(Br)ccc2o1 by adding a amide.,O=C([O-])CCCc1nc2cc(Br)ccc2o1,amide
168097,Modify the molecule C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C by adding a benzene ring.,C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C,benzene ring
106317,Add a hydroxyl to the molecule CN[C@]1(C#N)CC[C@@H](Oc2ccc(C)cc2)C1.,CN[C@]1(C#N)CC[C@@H](Oc2ccc(C)cc2)C1,hydroxyl
129640,Modify the molecule CCCCOC(=O)Cc1nnc(=O)[nH]c1[O-] by adding a halo.,CCCCOC(=O)Cc1nnc(=O)[nH]c1[O-],halo
65045,Modify the molecule CC[C@@H](COC)NC(=O)c1sc2cccc(C)c2c1Cl by adding a aldehyde.,CC[C@@H](COC)NC(=O)c1sc2cccc(C)c2c1Cl,aldehyde
186981,Add a amide to the molecule CCSc1nc(=O)c2c(n1C)NC(=O)C[C@@H]2c1c(F)cccc1Cl.,CCSc1nc(=O)c2c(n1C)NC(=O)C[C@@H]2c1c(F)cccc1Cl,amide
92554,Please add a benzene ring to the molecule CCS(=O)(=O)N1CC[NH+](Cc2cccc(OC)c2OC)CC1.,CCS(=O)(=O)N1CC[NH+](Cc2cccc(OC)c2OC)CC1,benzene ring